FLORANTEQUIOCHOFLORANTE QUIOCHO0.000000000000000.000000000000003138QUIOCHO, FLORANTEDistinguished Emeritus Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson25301948Sippel KH, Vyas NK, Zhang W, Sankaran B, Quiocho FAThe Journal of biological chemistryCrystal structure of the human fatty acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition. J Biol Chem. 2014 Nov 28; 289(48):33287-95.J Biol Chem2014-10-09T00:00:002014Crystal structure of the human fatty acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition.Authorship 811214Authorship 809681Authorship 811746Authorship 832852Authorship 890704Authorship 913823Authorship 896502Authorship 908474Authorship 937214Authorship 941212Authorship 943133Authorship 946064Authorship 967043Authorship 950464Authorship 974542Authorship 997835Authorship 983243Authorship 999404Authorship 101313Authorship 101845Authorship 1026425Authorship 106145Authorship 1084992Authorship 1090453Authorship 1101954Authorship 1106581Authorship 1119011Authorship 1122816Authorship 1146913Authorship 201425Authorship 214173Authorship 226794Authorship 263394Authorship 269554Authorship 277773Authorship 280124Authorship 281653Authorship 305022Authorship 316995Authorship 383922Authorship 394712Authorship 396895Molecular & Cellular OncologyMD AndersonAuthorship 420831Authorship 43694Authorship 495413Authorship 514991Authorship 57424Authorship 651331Authorship 6554511Authorship 7437013Authorship 769773Authorship 791915Authorship 793494Authorship 923133Authorship 937264Authorship 93854Authorship 954611Authorship 984784Authorship 9912642818726Quiocho FA, Wilson DK, Vyas NKNatureSubstrate specificity and affinity of a protein modulated by bound water molecules. Nature. 1989 Aug 03; 340(6232):404-7.Nature1989-08-03T00:00:001989Substrate specificity and affinity of a protein modulated by bound water molecules.2852259Jacobson BL, Quiocho FAJournal of molecular biologySulfate-binding protein dislikes protonated oxyacids. A molecular explanation. J Mol Biol. 1988 Dec 05; 204(3):783-7.J Mol Biol1988-12-05T00:00:001988Sulfate-binding protein dislikes protonated oxyacids. A molecular explanation.38241Miller DM, Newcomer ME, Quiocho FAThe Journal of biological chemistryThe thiol group of the L-arabinose-binding protein. Chromophoric labeling and chemical identification of the sugar-binding site. J Biol Chem. 1979 Aug 25; 254(16):7521-8.J Biol Chem1979-08-25T00:00:001979The thiol group of the L-arabinose-binding protein. Chromophoric labeling and chemical identification of the sugar-binding site.381285Newcomer ME, Miller DM, Quiocho FAThe Journal of biological chemistryLocation of the sugar-binding site of L-arabinose-binding protein. Sugar derivative syntheses, sugar binding specificity, and difference Fourier analyses. J Biol Chem. 1979 Aug 25; 254(16):7529-33.J Biol Chem1979-08-25T00:00:001979Location of the sugar-binding site of L-arabinose-binding protein. Sugar derivative syntheses, sugar binding specificity, and difference Fourier analyses.393831Quiocho FA, Meador WE, Pflugrath JWJournal of molecular biologyPreliminary crystallographic data of receptors for transport and chemotaxis in Escherichia coli: D-galactose and maltose-binding proteins. J Mol Biol. 1979 Sep 05; 133(1):181-4.J Mol Biol1979-09-05T00:00:001979Preliminary crystallographic data of receptors for transport and chemotaxis in Escherichia coli: D-galactose and maltose-binding proteins.3057628Vyas NK, Vyas MN, Quiocho FAScience (New York, N.Y.)Sugar and signal-transducer binding sites of the Escherichia coli galactose chemoreceptor protein. Science. 1988 Dec 02; 242(4883):1290-5.Science1988-12-02T00:00:001988Sugar and signal-transducer binding sites of the Escherichia coli galactose chemoreceptor protein.3288756Pflugrath JW, Quiocho FAJournal of molecular biologyThe 2 A resolution structure of the sulfate-binding protein involved in active transport in Salmonella typhimurium. J Mol Biol. 1988 Mar 05; 200(1):163-80.J Mol Biol1988-03-05T00:00:001988The 2 A resolution structure of the sulfate-binding protein involved in active transport in Salmonella typhimurium.3398052Wilson DK, Rudolph FB, Harrison ML, Kellems RE, Quiocho FAJournal of molecular biologyPreliminary X-ray analysis of crystals of murine adenosine deaminase. J Mol Biol. 1988 Apr 05; 200(3):613-4.J Mol Biol1988-04-05T00:00:001988Preliminary X-ray analysis of crystals of murine adenosine deaminase.3193133Wilcox GL, Quiocho FA, Levinthal C, Harvey SC, Maggiora GM, McCammon JAJournal of computer-aided molecular designSymposium overview. Minnesota Conference on Supercomputing in Biology: Proteins, Nucleic Acids, and Water. J Comput Aided Mol Des. 1988 Jan; 1(4):271-81.J Comput Aided Mol Des1988-01-01T00:00:001988Symposium overview. Minnesota Conference on Supercomputing in Biology: Proteins, Nucleic Acids, and Water.3435532Schroepfer GJ, Parish EJ, Kandutsch AA, Bowen ST, Quiocho FABiochemistry international15 beta-Methyl-5 alpha,14 beta-cholest-7-ene-3 beta,15 alpha-diol. Synthesis, structure, and inhibition of sterol synthesis in animal cells. Biochem Int. 1987 Aug; 15(2):403-8.Biochem Int1987-08-01T00:00:00198715 beta-Methyl-5 alpha,14 beta-cholest-7-ene-3 beta,15 alpha-diol. Synthesis, structure, and inhibition of sterol synthesis in animal cells.3191560Wilson DK, Wilson WK, Quiocho FA, Schroepfer GJChemistry and physics of lipidsCrystal structure of 3 beta-benzoyloxy-6 alpha-chloro-5 alpha-cholest-7-ene, a key intermediate in the chemical synthesis of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one. Chem Phys Lipids. 1988 Aug; 47(4):283-9.Chem Phys Lipids1988-08-01T00:00:001988Crystal structure of 3 beta-benzoyloxy-6 alpha-chloro-5 alpha-cholest-7-ene, a key intermediate in the chemical synthesis of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one.3519617Kubena BD, Luecke H, Rosenberg H, Quiocho FAThe Journal of biological chemistryCrystallization and x-ray diffraction studies of a phosphate-binding protein involved in active transport in Escherichia coli. J Biol Chem. 1986 Jun 15; 261(17):7995-6.J Biol Chem1986-06-15T00:00:001986Crystallization and x-ray diffraction studies of a phosphate-binding protein involved in active transport in Escherichia coli.3365828Bowen ST, Parish EJ, Wilson WK, Schroepfer GJ, Quiocho FAChemistry and physics of lipidsInhibitors of sterol synthesis. Concerning the structure of 15 beta-methyl-5 alpha,14 beta-cholest-7-ene-3 beta,15 alpha-diol, an inhibitor of cholesterol biosynthesis. Chem Phys Lipids. 1988 Apr; 46(4):245-51.Chem Phys Lipids1988-04-01T00:00:001988Inhibitors of sterol synthesis. Concerning the structure of 15 beta-methyl-5 alpha,14 beta-cholest-7-ene-3 beta,15 alpha-diol, an inhibitor of cholesterol biosynthesis.3885043Pflugrath JW, Quiocho FANatureSulphate sequestered in the sulphate-binding protein of Salmonella typhimurium is bound solely by hydrogen bonds. Nature. 1985 Mar 21-27; 314(6008):257-60.Nature1985-03-01T00:00:001985Sulphate sequestered in the sulphate-binding protein of Salmonella typhimurium is bound solely by hydrogen bonds.3527044Quiocho FAAnnual review of biochemistryCarbohydrate-binding proteins: tertiary structures and protein-sugar interactions. Annu Rev Biochem. 1986; 55:287-315.Annu Rev Biochem1986-01-01T00:00:001986Carbohydrate-binding proteins: tertiary structures and protein-sugar interactions.4509052Reeke GN, Becker JW, Quiocho FACold Spring Harbor symposia on quantitative biologyThe structure of concanavalin A at 4 A resolution. Cold Spring Harb Symp Quant Biol. 1972; 36:277-84.Cold Spring Harb Symp Quant Biol1972-01-01T00:00:001972The structure of concanavalin A at 4 A resolution.3657977Quiocho FA, Sack JS, Vyas NKNatureStabilization of charges on isolated ionic groups sequestered in proteins by polarized peptide units. Nature. 1987 Oct 8-14; 329(6139):561-4.Nature1987-10-01T00:00:001987Stabilization of charges on isolated ionic groups sequestered in proteins by polarized peptide units.5263013Lipscomb WN, Hartsuck JA, Quiocho FA, Reeke GNProceedings of the National Academy of Sciences of the United States of AmericaThe structure of carboxypeptidase A. IX. The x-ray diffraction results in the light of the chemical sequence. Proc Natl Acad Sci U S A. 1969 Sep; 64(1):28-35.Proc Natl Acad Sci U S A1969-09-01T00:00:001969The structure of carboxypeptidase A. IX. The x-ray diffraction results in the light of the chemical sequence.5719196Lipscomb WN, Hartsuck JA, Reeke GN, Quiocho FA, Bethge PH, Ludwig ML, Steitz TA, Muirhead H, Coppola JCBrookhaven symposia in biologyThe structure of carboxypeptidase A. VII. The 2.0-angstrom resolution studies of the enzyme and of its complex with glycyltyrosine, and mechanistic deductions. Brookhaven Symp Biol. 1968 Jun; 21(1):24-90.Brookhaven Symp Biol1968-06-01T00:00:001968The structure of carboxypeptidase A. VII. The 2.0-angstrom resolution studies of the enzyme and of its complex with glycyltyrosine, and mechanistic deductions.6350301Saper MA, Quiocho FAThe Journal of biological chemistryLeucine, isoleucine, valine-binding protein from Escherichia coli. Structure at 3.0-A resolution and location of the binding site. J Biol Chem. 1983 Sep 25; 258(18):11057-62.J Biol Chem1983-09-25T00:00:001983Leucine, isoleucine, valine-binding protein from Escherichia coli. Structure at 3.0-A resolution and location of the binding site.4416451Quiocho FA, Olson JSThe Journal of biological chemistryThe reaction of creatine kinase with 2-chloromercuri-4-nitrophenol. J Biol Chem. 1974 Sep 25; 249(18):5885-8.J Biol Chem1974-09-25T00:00:001974The reaction of creatine kinase with 2-chloromercuri-4-nitrophenol.7021859Gilliland GL, Quiocho FAJournal of molecular biologyStructure of the L-arabinose-binding protein from Escherichia coli at 2.4 A resolution. J Mol Biol. 1981 Mar 05; 146(3):341-62.J Mol Biol1981-03-05T00:00:001981Structure of the L-arabinose-binding protein from Escherichia coli at 2.4 A resolution.7031057Newcomer ME, Gilliland GL, Quiocho FAThe Journal of biological chemistryL-Arabinose-binding protein-sugar complex at 2.4 A resolution. Stereochemistry and evidence for a structural change. J Biol Chem. 1981 Dec 25; 256(24):13213-7.J Biol Chem1981-12-25T00:00:001981L-Arabinose-binding protein-sugar complex at 2.4 A resolution. Stereochemistry and evidence for a structural change.7031058Newcomer ME, Lewis BA, Quiocho FAThe Journal of biological chemistryThe radius of gyration of L-arabinose-binding protein decreases upon binding of ligand. J Biol Chem. 1981 Dec 25; 256(24):13218-22.J Biol Chem1981-12-25T00:00:001981The radius of gyration of L-arabinose-binding protein decreases upon binding of ligand.4508168Quiocho FA, Bethge PH, Lipscomb WN, Studebaker JF, Brown RD, Koenig SHCold Spring Harbor symposia on quantitative biologyX-ray diffraction and nuclear magnetic resonance dispersion studies on derivatives of carboxypeptidase A. Cold Spring Harb Symp Quant Biol. 1972; 36:561-7.Cold Spring Harb Symp Quant Biol1972-01-01T00:00:001972X-ray diffraction and nuclear magnetic resonance dispersion studies on derivatives of carboxypeptidase A.4606729Quiocho FA, Phillips GN, Parsons RG, Hogg RWJournal of molecular biologyLetter: Crystallographic data of an L-arabinose-binding protein from Escherichia coli. J Mol Biol. 1974 Jun 25; 86(2):491-3.J Mol Biol1974-06-25T00:00:001974Letter: Crystallographic data of an L-arabinose-binding protein from Escherichia coli.7578036Wilson DK, Nakano T, Petrash JM, Quiocho FABiochemistry1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor. Biochemistry. 1995 Nov 07; 34(44):14323-30.Biochemistry1995-11-07T00:00:0019951.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor.6061411Steitz TA, Ludwig ML, Quiocho FA, Lipscomb WNThe Journal of biological chemistryThe structure of carboxypepidase A. V. Studies of enzyme-substrate and enzyme-inhibitor complexes at 6 A resolution. J Biol Chem. 1967 Oct 25; 242(20):4662-8.J Biol Chem1967-10-25T00:00:001967The structure of carboxypepidase A. V. Studies of enzyme-substrate and enzyme-inhibitor complexes at 6 A resolution.6340108Vyas NK, Vyas MN, Quiocho FAProceedings of the National Academy of Sciences of the United States of AmericaThe 3 A resolution structure of a D-galactose-binding protein for transport and chemotaxis in Escherichia coli. Proc Natl Acad Sci U S A. 1983 Apr; 80(7):1792-6.Proc Natl Acad Sci U S A1983-04-01T00:00:001983The 3 A resolution structure of a D-galactose-binding protein for transport and chemotaxis in Escherichia coli.6358208Miller DM, Olson JS, Pflugrath JW, Quiocho FAThe Journal of biological chemistryRates of ligand binding to periplasmic proteins involved in bacterial transport and chemotaxis. J Biol Chem. 1983 Nov 25; 258(22):13665-72.J Biol Chem1983-11-25T00:00:001983Rates of ligand binding to periplasmic proteins involved in bacterial transport and chemotaxis.6379466Quiocho FA, Vyas NKNatureNovel stereospecificity of the L-arabinose-binding protein. Nature. 1984 Aug 2-8; 310(5976):381-6.Nature1984-08-01T00:00:001984Novel stereospecificity of the L-arabinose-binding protein.7756999Choudhary A, Vyas MN, Vyas NK, Chang Z, Quiocho FAProtein science : a publication of the Protein SocietyCrystallization and preliminary X-ray crystallographic analysis of the 38-kDa immunodominant antigen of Mycobacterium tuberculosis. Protein Sci. 1994 Dec; 3(12):2450-1.Protein Sci1994-12-01T00:00:001994Crystallization and preliminary X-ray crystallographic analysis of the 38-kDa immunodominant antigen of Mycobacterium tuberculosis.781669Phillips GN, Mahajan VK, Siu AK, Quiocho FAProceedings of the National Academy of Sciences of the United States of AmericaStructure of L-arabinose-binding protein from Escherichia coli at 5 A resolution and preliminary results at 3.5 A. Proc Natl Acad Sci U S A. 1976 Jul; 73(7):2186-90.Proc Natl Acad Sci U S A1976-07-01T00:00:001976Structure of L-arabinose-binding protein from Escherichia coli at 5 A resolution and preliminary results at 3.5 A.6987223Miller DM, Olson JS, Quiocho FAThe Journal of biological chemistryThe mechanism of sugar binding to the periplasmic receptor for galactose chemotaxis and transport in Escherichia coli. J Biol Chem. 1980 Mar 25; 255(6):2465-71.J Biol Chem1980-03-25T00:00:001980The mechanism of sugar binding to the periplasmic receptor for galactose chemotaxis and transport in Escherichia coli.6993475Quiocho FA, Pflugrath JWThe Journal of biological chemistryThe structure of D-galactose-binding protein at 4.1 A resolution looks like L-arabinose-binding protein. J Biol Chem. 1980 Jul 25; 255(14):6559-51.J Biol Chem1980-07-25T00:00:001980The structure of D-galactose-binding protein at 4.1 A resolution looks like L-arabinose-binding protein.7929197Wang Z, Choudhary A, Ledvina PS, Quiocho FAThe Journal of biological chemistryFine tuning the specificity of the periplasmic phosphate transport receptor. Site-directed mutagenesis, ligand binding, and crystallographic studies. J Biol Chem. 1994 Oct 07; 269(40):25091-4.J Biol Chem1994-10-07T00:00:001994Fine tuning the specificity of the periplasmic phosphate transport receptor. Site-directed mutagenesis, ligand binding, and crystallographic studies.8039602Petrash JM, Tarle I, Wilson DK, Quiocho FADiabetesAldose reductase catalysis and crystallography. Insights from recent advances in enzyme structure and function. Diabetes. 1994 Aug; 43(8):955-9.Diabetes1994-08-01T00:00:001994Aldose reductase catalysis and crystallography. Insights from recent advances in enzyme structure and function.7634072Wilson DK, Quiocho FANature structural biologyCrystallographic observation of a trapped tetrahedral intermediate in a metalloenzyme. Nat Struct Biol. 1994 Oct; 1(10):691-4.Nat Struct Biol1994-10-01T00:00:001994Crystallographic observation of a trapped tetrahedral intermediate in a metalloenzyme.8245005Tarle I, Borhani DW, Wilson DK, Quiocho FA, Petrash JMThe Journal of biological chemistryProbing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110. J Biol Chem. 1993 Dec 05; 268(34):25687-93.J Biol Chem1993-12-05T00:00:001993Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110.7035444Mao B, Pear MR, McCammon JA, Quiocho FAThe Journal of biological chemistryHinge-bending in L-arabinose-binding protein. The "Venus's-flytrap" model. J Biol Chem. 1982 Feb 10; 257(3):1131-3.J Biol Chem1982-02-10T00:00:001982Hinge-bending in L-arabinose-binding protein. The "Venus's-flytrap" model.8359506Quiocho FABiochemical Society transactionsProbing the atomic interactions between proteins and carbohydrates. Biochem Soc Trans. 1993 May; 21(2):442-8.Biochem Soc Trans1993-05-01T00:00:001993Probing the atomic interactions between proteins and carbohydrates.8439534Wilson DK, Quiocho FABiochemistryA pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water. Biochemistry. 1993 Feb 23; 32(7):1689-94.Biochemistry1993-02-23T00:00:001993A pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water.8259515Meador WE, Means AR, Quiocho FAScience (New York, N.Y.)Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures. Science. 1993 Dec 10; 262(5140):1718-21.Science1993-12-10T00:00:001993Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.8455714Quiocho FANatureProtein engineering. Making of the minibody. Nature. 1993 Mar 25; 362(6418):293-4.Nature1993-03-25T00:00:001993Protein engineering. Making of the minibody.7371118Newcomer ME, Gilliland GL, Parish EJ, Schroepfer GJ, Quiocho FAChemistry and physics of lipidsConcerning the structure of 7 alpha,15 beta-dichloro-5 alpha-cholest-8(14)-en-3 beta-ol, a novel inhibitor of cholesterol biosynthesis. Chem Phys Lipids. 1980 Apr; 26(3):249-58.Chem Phys Lipids1980-04-01T00:00:001980Concerning the structure of 7 alpha,15 beta-dichloro-5 alpha-cholest-8(14)-en-3 beta-ol, a novel inhibitor of cholesterol biosynthesis.8338840Zacharias M, Straatsma TP, McCammon JA, Quiocho FABiochemistryInversion of receptor binding preferences by mutagenesis: free energy thermodynamic integration studies on sugar binding to L-arabinose binding proteins. Biochemistry. 1993 Jul 27; 32(29):7428-34.Biochemistry1993-07-27T00:00:001993Inversion of receptor binding preferences by mutagenesis: free energy thermodynamic integration studies on sugar binding to L-arabinose binding proteins.8344909Olah GA, Trakhanov S, Trewhella J, Quiocho FAThe Journal of biological chemistryLeucine/isoleucine/valine-binding protein contracts upon binding of ligand. J Biol Chem. 1993 Aug 05; 268(22):16241-7.J Biol Chem1993-08-05T00:00:001993Leucine/isoleucine/valine-binding protein contracts upon binding of ligand.8349639Nichols JC, Vyas NK, Quiocho FA, Matthews KSThe Journal of biological chemistryModel of lactose repressor core based on alignment with sugar-binding proteins is concordant with genetic and chemical data. J Biol Chem. 1993 Aug 15; 268(23):17602-12.J Biol Chem1993-08-15T00:00:001993Model of lactose repressor core based on alignment with sugar-binding proteins is concordant with genetic and chemical data.8527431Nickitenko AV, Trakhanov S, Quiocho FABiochemistry2 A resolution structure of DppA, a periplasmic dipeptide transport/chemosensory receptor. Biochemistry. 1995 Dec 26; 34(51):16585-95.Biochemistry1995-12-26T00:00:0019952 A resolution structure of DppA, a periplasmic dipeptide transport/chemosensory receptor.8568817Marrone TJ, Straatsma TP, Briggs JM, Wilson DK, Quiocho FA, McCammon JAJournal of medicinal chemistryTheoretical study of inhibition of adenosine deaminase by (8R)-coformycin and (8R)-deoxycoformycin. J Med Chem. 1996 Jan 05; 39(1):277-84.J Med Chem1996-01-05T00:00:001996Theoretical study of inhibition of adenosine deaminase by (8R)-coformycin and (8R)-deoxycoformycin.8496958Vyas MN, Vyas NK, Meikle PJ, Sinnott B, Pinto BM, Bundle DR, Quiocho FAJournal of molecular biologyPreliminary crystallographic analysis of a Fab specific for the O-antigen of Shigella flexneri cell surface lipopolysaccharide with and without bound saccharides. J Mol Biol. 1993 May 05; 231(1):133-6.J Mol Biol1993-05-05T00:00:001993Preliminary crystallographic analysis of a Fab specific for the O-antigen of Shigella flexneri cell surface lipopolysaccharide with and without bound saccharides.870048Somerville LL, Quiocho FABiochimica et biophysica actaThe interaction of tetraiodofluorescein with creatine kinase. Biochim Biophys Acta. 1977 Apr 12; 481(2):493-9.Biochim Biophys Acta1977-04-12T00:00:001977The interaction of tetraiodofluorescein with creatine kinase.870214Conner BN, Parish EJ, Schroepfer GJ, Quiocho FAChemistry and physics of lipidsSynthesis an crystal structure of 3beta-p-bromobenzoyloxy-14alpha, 15alpha-epoxy-5alpha-cholest-7-ene. Chem Phys Lipids. 1977 Apr; 18(3-4):240-7.Chem Phys Lipids1977-04-01T00:00:001977Synthesis an crystal structure of 3beta-p-bromobenzoyloxy-14alpha, 15alpha-epoxy-5alpha-cholest-7-ene.8528088Trakhanov S, Quiocho FAProtein science : a publication of the Protein SocietyInfluence of divalent cations in protein crystallization. Protein Sci. 1995 Sep; 4(9):1914-9.Protein Sci1995-09-01T00:00:001995Influence of divalent cations in protein crystallization.8602256Johnson KA, Quiocho FANatureProtein kinases. Twitching worms catch S100. Nature. 1996 Apr 18; 380(6575):585-7.Nature1996-04-18T00:00:001996Protein kinases. Twitching worms catch S100.8652549Yao N, Ledvina PS, Choudhary A, Quiocho FABiochemistryModulation of a salt link does not affect binding of phosphate to its specific active transport receptor. Biochemistry. 1996 Feb 20; 35(7):2079-85.Biochemistry1996-02-20T00:00:001996Modulation of a salt link does not affect binding of phosphate to its specific active transport receptor.8636160Chang Z, Primm TP, Jakana J, Lee IH, Serysheva I, Chiu W, Gilbert HF, Quiocho FAThe Journal of biological chemistryMycobacterium tuberculosis 16-kDa antigen (Hsp16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation. J Biol Chem. 1996 Mar 22; 271(12):7218-23.J Biol Chem1996-03-22T00:00:001996Mycobacterium tuberculosis 16-kDa antigen (Hsp16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation.8672487Sideraki V, Mohamedali KA, Wilson DK, Chang Z, Kellems RE, Quiocho FA, Rudolph FBBiochemistryProbing the functional role of two conserved active site aspartates in mouse adenosine deaminase. Biochemistry. 1996 Jun 18; 35(24):7862-72.Biochemistry1996-06-18T00:00:001996Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.8692896Ledvina PS, Yao N, Choudhary A, Quiocho FAProceedings of the National Academy of Sciences of the United States of AmericaNegative electrostatic surface potential of protein sites specific for anionic ligands. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6786-91.Proc Natl Acad Sci U S A1996-06-25T00:00:001996Negative electrostatic surface potential of protein sites specific for anionic ligands.7795522Cannon WR, Briggs JM, Shen J, McCammon JA, Quiocho FAProtein science : a publication of the Protein SocietyConservative and nonconservative mutations in proteins: anomalous mutations in a transport receptor analyzed by free energy and quantum chemical calculations. Protein Sci. 1995 Mar; 4(3):387-93.Protein Sci1995-03-01T00:00:001995Conservative and nonconservative mutations in proteins: anomalous mutations in a transport receptor analyzed by free energy and quantum chemical calculations.9038155Chin D, Sloan DJ, Quiocho FA, Means ARThe Journal of biological chemistryFunctional consequences of truncating amino acid side chains located at a calmodulin-peptide interface. J Biol Chem. 1997 Feb 28; 272(9):5510-3.J Biol Chem1997-02-28T00:00:001997Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface.7853407Sharff AJ, Rodseth LE, Szmelcman S, Hofnung M, Quiocho FAJournal of molecular biologyRefined structures of two insertion/deletion mutants probe function of the maltodextrin binding protein. J Mol Biol. 1995 Feb 10; 246(1):8-13.J Mol Biol1995-02-10T00:00:001995Refined structures of two insertion/deletion mutants probe function of the maltodextrin binding protein.9059648Wilson DK, Nakano T, Petrash JM, Quiocho FAAdvances in experimental medicine and biologyStructural studies of aldo-keto reductase inhibition. Adv Exp Med Biol. 1997; 414:435-42.Adv Exp Med Biol1997-01-01T00:00:001997Structural studies of aldo-keto reductase inhibition.8969219Cappiello M, Voltarelli M, Cecconi I, Vilardo PG, Dal Monte M, Marini I, Del Corso A, Wilson DK, Quiocho FA, Petrash JM, Mura UThe Journal of biological chemistrySpecifically targeted modification of human aldose reductase by physiological disulfides. J Biol Chem. 1996 Dec 27; 271(52):33539-44.J Biol Chem1996-12-27T00:00:001996Specifically targeted modification of human aldose reductase by physiological disulfides.9144774Cooper BF, Sideraki V, Wilson DK, Dominguez DY, Clark SW, Quiocho FA, Rudolph FBProtein science : a publication of the Protein SocietyThe role of divalent cations in structure and function of murine adenosine deaminase. Protein Sci. 1997 May; 6(5):1031-7.Protein Sci1997-05-01T00:00:001997The role of divalent cations in structure and function of murine adenosine deaminase.9145102Hodel AE, Gershon PD, Shi X, Wang SM, Quiocho FANature structural biologySpecific protein recognition of an mRNA cap through its alkylated base. Nat Struct Biol. 1997 May; 4(5):350-4.Nat Struct Biol1997-05-01T00:00:001997Specific protein recognition of an mRNA cap through its alkylated base.9195880Tabernero L, Taylor DA, Chandross RJ, VanBerkum MF, Means AR, Quiocho FA, Sack JSStructure (London, England : 1993)The structure of a calmodulin mutant with a deletion in the central helix: implications for molecular recognition and protein binding. Structure. 1997 May 15; 5(5):613-22.Structure1997-05-15T00:00:001997The structure of a calmodulin mutant with a deletion in the central helix: implications for molecular recognition and protein binding.9540203Thomson J, Liu Y, Sturtevant JM, Quiocho FABiophysical chemistryA thermodynamic study of the binding of linear and cyclic oligosaccharides to the maltodextrin-binding protein of Escherichia coli. Biophys Chem. 1998 Feb 16; 70(2):101-8.Biophys Chem1998-02-16T00:00:001998A thermodynamic study of the binding of linear and cyclic oligosaccharides to the maltodextrin-binding protein of Escherichia coli.9622483Wang Z, Quiocho FABiochemistryComplexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity. Biochemistry. 1998 Jun 09; 37(23):8314-24.Biochemistry1998-06-09T00:00:001998Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.9622508Lockless SW, Cheng HT, Hodel AE, Quiocho FA, Gershon PDBiochemistryRecognition of capped RNA substrates by VP39, the vaccinia virus-encoded mRNA cap-specific 2'-O-methyltransferase. Biochemistry. 1998 Jun 09; 37(23):8564-74.Biochemistry1998-06-09T00:00:001998Recognition of capped RNA substrates by VP39, the vaccinia virus-encoded mRNA cap-specific 2'-O-methyltransferase.8161535Vyas MN, Vyas NK, Quiocho FABiochemistryCrystallographic analysis of the epimeric and anomeric specificity of the periplasmic transport/chemosensory protein receptor for D-glucose and D-galactose. Biochemistry. 1994 Apr 26; 33(16):4762-8.Biochemistry1994-04-26T00:00:001994Crystallographic analysis of the epimeric and anomeric specificity of the periplasmic transport/chemosensory protein receptor for D-glucose and D-galactose.8234324Wilson DK, Tarle I, Petrash JM, Quiocho FAProceedings of the National Academy of Sciences of the United States of AmericaRefined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):9847-51.Proc Natl Acad Sci U S A1993-11-01T00:00:001993Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.8251939He JJ, Quiocho FAProtein science : a publication of the Protein SocietyDominant role of local dipoles in stabilizing uncompensated charges on a sulfate sequestered in a periplasmic active transport protein. Protein Sci. 1993 Oct; 2(10):1643-7.Protein Sci1993-10-01T00:00:001993Dominant role of local dipoles in stabilizing uncompensated charges on a sulfate sequestered in a periplasmic active transport protein.9804821Gimble FS, Duan X, Hu D, Quiocho FAThe Journal of biological chemistryIdentification of Lys-403 in the PI-SceI homing endonuclease as part of a symmetric catalytic center. J Biol Chem. 1998 Nov 13; 273(46):30524-9.J Biol Chem1998-11-13T00:00:001998Identification of Lys-403 in the PI-SceI homing endonuclease as part of a symmetric catalytic center.8294447Chang Z, Choudhary A, Lathigra R, Quiocho FAThe Journal of biological chemistryThe immunodominant 38-kDa lipoprotein antigen of Mycobacterium tuberculosis is a phosphate-binding protein. J Biol Chem. 1994 Jan 21; 269(3):1956-8.J Biol Chem1994-01-21T00:00:001994The immunodominant 38-kDa lipoprotein antigen of Mycobacterium tuberculosis is a phosphate-binding protein.9865949Ledvina PS, Tsai AL, Wang Z, Koehl E, Quiocho FAProtein science : a publication of the Protein SocietyDominant role of local dipolar interactions in phosphate binding to a receptor cleft with an electronegative charge surface: equilibrium, kinetic, and crystallographic studies. Protein Sci. 1998 Dec; 7(12):2550-9.Protein Sci1998-12-01T00:00:001998Dominant role of local dipolar interactions in phosphate binding to a receptor cleft with an electronegative charge surface: equilibrium, kinetic, and crystallographic studies.8464075Rodseth L, Quiocho FAJournal of molecular biologyCrystallization of the maltodextrin-binding protein for active transport and chemotaxis in several different liganded and mutant forms. J Mol Biol. 1993 Mar 20; 230(2):675-8.J Mol Biol1993-03-20T00:00:001993Crystallization of the maltodextrin-binding protein for active transport and chemotaxis in several different liganded and mutant forms.10679461Quiocho FA, Hu G, Gershon PDCurrent opinion in structural biologyStructural basis of mRNA cap recognition by proteins. Curr Opin Struct Biol. 2000 Feb; 10(1):78-86.Curr Opin Struct Biol2000-02-01T00:00:002000Structural basis of mRNA cap recognition by proteins.10693761Mao Y, Nickitenko A, Duan X, Lloyd TE, Wu MN, Bellen H, Quiocho FACellCrystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction. Cell. 2000 Feb 18; 100(4):447-56.Cell2000-02-18T00:00:002000Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction.Authorship 295539210828056Poland BW, Xu MQ, Quiocho FAThe Journal of biological chemistryStructural insights into the protein splicing mechanism of PI-SceI. J Biol Chem. 2000 Jun 02; 275(22):16408-13.J Biol Chem2000-06-02T00:00:002000Structural insights into the protein splicing mechanism of PI-SceI.1474585Chattopadhyaya R, Meador WE, Means AR, Quiocho FAJournal of molecular biologyCalmodulin structure refined at 1.7 A resolution. J Mol Biol. 1992 Dec 20; 228(4):1177-92.J Mol Biol1992-12-20T00:00:001992Calmodulin structure refined at 1.7 A resolution.25866296Sippel KH, Quiocho FAProtein science : a publication of the Protein SocietyIon-dipole interactions and their functions in proteins. Protein Sci. 2015 Jul; 24(7):1040-6.Protein Sci2015-05-01T00:00:002015Ion-dipole interactions and their functions in proteins.11237621Duan X, Hall JA, Nikaido H, Quiocho FAJournal of molecular biologyCrystal structures of the maltodextrin/maltose-binding protein complexed with reduced oligosaccharides: flexibility of tertiary structure and ligand binding. J Mol Biol. 2001 Mar 09; 306(5):1115-26.J Mol Biol2001-03-09T00:00:002001Crystal structures of the maltodextrin/maltose-binding protein complexed with reduced oligosaccharides: flexibility of tertiary structure and ligand binding.1420181Sharff AJ, Rodseth LE, Spurlino JC, Quiocho FABiochemistryCrystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis. Biochemistry. 1992 Nov 10; 31(44):10657-63.Biochemistry1992-11-10T00:00:001992Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis.11911875Lohi O, Poussu A, Mao Y, Quiocho F, Lehto VPFEBS lettersVHS domain -- a longshoreman of vesicle lines. FEBS Lett. 2002 Feb 20; 513(1):19-23.FEBS Lett2002-02-20T00:00:002002VHS domain -- a longshoreman of vesicle lines.1309886Jacobson BL, He JJ, Lemon DD, Quiocho FAJournal of molecular biologyInterdomain salt bridges modulate ligand-induced domain motion of the sulfate receptor protein for active transport. J Mol Biol. 1992 Jan 05; 223(1):27-30.J Mol Biol1992-01-05T00:00:001992Interdomain salt bridges modulate ligand-induced domain motion of the sulfate receptor protein for active transport.9309217Quiocho FA, Spurlino JC, Rodseth LEStructure (London, England : 1993)Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor. Structure. 1997 Aug 15; 5(8):997-1015.Structure1997-08-15T00:00:001997Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor.12574112Bowman BR, Baker ML, Rixon FJ, Chiu W, Quiocho FAThe EMBO journalStructure of the herpesvirus major capsid protein. EMBO J. 2003 Feb 17; 22(4):757-65.EMBO J2003-02-17T00:00:002003Structure of the herpesvirus major capsid protein.9468518He Z, Crist M, Yen H, Duan X, Quiocho FA, Gimble FSThe Journal of biological chemistryAmino acid residues in both the protein splicing and endonuclease domains of the PI-SceI intein mediate DNA binding. J Biol Chem. 1998 Feb 20; 273(8):4607-15.J Biol Chem1998-02-20T00:00:001998Amino acid residues in both the protein splicing and endonuclease domains of the PI-SceI intein mediate DNA binding.12842040Vyas NK, Vyas MN, Quiocho FAStructure (London, England : 1993)Crystal structure of M tuberculosis ABC phosphate transport receptor: specificity and charge compensation dominated by ion-dipole interactions. Structure. 2003 Jul; 11(7):765-74.Structure2003-07-01T00:00:002003Crystal structure of M tuberculosis ABC phosphate transport receptor: specificity and charge compensation dominated by ion-dipole interactions.1518061Sharff AJ, Wilson DK, Chang Z, Quiocho FAJournal of molecular biologyRefined 2.5 A structure of murine adenosine deaminase at pH 6.0. J Mol Biol. 1992 Aug 20; 226(4):917-21.J Mol Biol1992-08-20T00:00:001992Refined 2.5 A structure of murine adenosine deaminase at pH 6.0.1518062Vermersch PS, Tesmer JJ, Quiocho FAJournal of molecular biologyProtein-ligand energetics assessed using deoxy and fluorodeoxy sugars in equilibrium binding and high resolution crystallographic studies. J Mol Biol. 1992 Aug 20; 226(4):923-9.J Mol Biol1992-08-20T00:00:001992Protein-ligand energetics assessed using deoxy and fluorodeoxy sugars in equilibrium binding and high resolution crystallographic studies.12888351Baker ML, Jiang W, Bowman BR, Zhou ZH, Quiocho FA, Rixon FJ, Chiu WJournal of molecular biologyArchitecture of the herpes simplex virus major capsid protein derived from structural bioinformatics. J Mol Biol. 2003 Aug 08; 331(2):447-56.J Mol Biol2003-08-08T00:00:002003Architecture of the herpes simplex virus major capsid protein derived from structural bioinformatics.9756955El-Kabbani O, Wilson DK, Petrash M, Quiocho FAMolecular visionStructural features of the aldose reductase and aldehyde reductase inhibitor-binding sites. Mol Vis. 1998 Sep 29; 4:19.Mol Vis1998-09-29T00:00:001998Structural features of the aldose reductase and aldehyde reductase inhibitor-binding sites.14573618Hu G, Tsai AL, Quiocho FAThe Journal of biological chemistryInsertion of an N7-methylguanine mRNA cap between two coplanar aromatic residues of a cap-binding protein is fast and selective for a positively charged cap. J Biol Chem. 2003 Dec 19; 278(51):51515-20.J Biol Chem2003-10-22T00:00:002003Insertion of an N7-methylguanine mRNA cap between two coplanar aromatic residues of a cap-binding protein is fast and selective for a positively charged cap.10377383Hu G, Gershon PD, Hodel AE, Quiocho FAProceedings of the National Academy of Sciences of the United States of AmericamRNA cap recognition: dominant role of enhanced stacking interactions between methylated bases and protein aromatic side chains. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7149-54.Proc Natl Acad Sci U S A1999-06-22T00:00:001999mRNA cap recognition: dominant role of enhanced stacking interactions between methylated bases and protein aromatic side chains.14636596Moure CM, Gimble FS, Quiocho FAJournal of molecular biologyThe crystal structure of the gene targeting homing endonuclease I-SceI reveals the origins of its target site specificity. J Mol Biol. 2003 Dec 05; 334(4):685-95.J Mol Biol2003-12-05T00:00:002003The crystal structure of the gene targeting homing endonuclease I-SceI reveals the origins of its target site specificity.One Baylor PlazaHouston, 77030TX74Professor10Assistant Professor54Instructor21Chair14Associate Professor46Distinguished Emeritus Professor47Distinguished Service Professor12219083Moure CM, Gimble FS, Quiocho FANature structural biologyCrystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence. Nat Struct Biol. 2002 Oct; 9(10):764-70.Nat Struct Biol2002-10-01T00:00:002002Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence.11239400Mao Y, Chen J, Maynard JA, Zhang B, Quiocho FACellA novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis. Cell. 2001 Feb 09; 104(3):433-40.Cell2001-02-09T00:00:002001A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis.1621098Wilson DK, Bohren KM, Gabbay KH, Quiocho FAScience (New York, N.Y.)An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science. 1992 Jul 03; 257(5066):81-4.Science1992-07-03T00:00:001992An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.JOHNTAINERJOHN TAINER11926TAINER, JOHNProfessor1848243Vyas NK, Vyas MN, Quiocho FAThe Journal of biological chemistryComparison of the periplasmic receptors for L-arabinose, D-glucose/D-galactose, and D-ribose. Structural and Functional Similarity. J Biol Chem. 1991 Mar 15; 266(8):5226-37.J Biol Chem1991-03-15T00:00:001991Comparison of the periplasmic receptors for L-arabinose, D-glucose/D-galactose, and D-ribose. Structural and Functional Similarity.11790091Duan X, Quiocho FABiochemistryStructural evidence for a dominant role of nonpolar interactions in the binding of a transport/chemosensory receptor to its highly polar ligands. Biochemistry. 2002 Jan 22; 41(3):706-12.Biochemistry2002-01-22T00:00:002002Structural evidence for a dominant role of nonpolar interactions in the binding of a transport/chemosensory receptor to its highly polar ligands.16155582Wu S, Mehta SQ, Pichaud F, Bellen HJ, Quiocho FANature structural & molecular biologySec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo. Nat Struct Mol Biol. 2005 Oct; 12(10):879-85.Nat Struct Mol Biol2005-09-11T00:00:002005Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo.16338416Fallon JL, Halling DB, Hamilton SL, Quiocho FAStructure (London, England : 1993)Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel. Structure. 2005 Dec; 13(12):1881-6.Structure2005-12-01T00:00:002005Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel.16407074Bowman BR, Moure CM, Kirtane BM, Welschhans RL, Tominaga K, Pereira-Smith OM, Quiocho FAStructure (London, England : 1993)Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. Structure. 2006 Jan; 14(1):151-8.Structure2006-01-01T00:00:002006Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain.16678106Moure CM, Bowman BR, Gershon PD, Quiocho FAMolecular cellCrystal structures of the vaccinia virus polyadenylate polymerase heterodimer: insights into ATP selectivity and processivity. Mol Cell. 2006 May 05; 22(3):339-49.Mol Cell2006-05-05T00:00:002006Crystal structures of the vaccinia virus polyadenylate polymerase heterodimer: insights into ATP selectivity and processivity.14212562QUIOCHO FA, RICHARDS FMProceedings of the National Academy of Sciences of the United States of AmericaINTERMOLECULAR CROSS LINKING OF A PROTEIN IN THE CRYSTALLINE STATE: CARBOXYPEPTIDASE-A. Proc Natl Acad Sci U S A. 1964 Sep; 52:833-9.Proc Natl Acad Sci U S A1964-09-01T00:00:001964INTERMOLECULAR CROSS LINKING OF A PROTEIN IN THE CRYSTALLINE STATE: CARBOXYPEPTIDASE-A.1694248Rodseth LE, Martineau P, Duplay P, Hofnung M, Quiocho FAJournal of molecular biologyCrystallization of genetically engineered active maltose-binding proteins, including an immunogenic viral epitope insertion. J Mol Biol. 1990 Jun 20; 213(4):607-11.J Mol Biol1990-06-20T00:00:001990Crystallization of genetically engineered active maltose-binding proteins, including an immunogenic viral epitope insertion.1619648Spurlino JC, Rodseth LE, Quiocho FAJournal of molecular biologyAtomic interactions in protein-carbohydrate complexes. Tryptophan residues in the periplasmic maltodextrin receptor for active transport and chemotaxis. J Mol Biol. 1992 Jul 05; 226(1):15-22.J Mol Biol1992-07-05T00:00:001992Atomic interactions in protein-carbohydrate complexes. Tryptophan residues in the periplasmic maltodextrin receptor for active transport and chemotaxis.1970641Quiocho FAPhilosophical transactions of the Royal Society of London. Series B, Biological sciencesAtomic structures of periplasmic binding proteins and the high-affinity active transport systems in bacteria. Philos Trans R Soc Lond B Biol Sci. 1990 Jan 30; 326(1236):341-51; discussion 351-2.Philos Trans R Soc Lond B Biol Sci1990-01-30T00:00:001990Atomic structures of periplasmic binding proteins and the high-affinity active transport systems in bacteria.2000410Aqvist J, Luecke H, Quiocho FA, Warshel AProceedings of the National Academy of Sciences of the United States of AmericaDipoles localized at helix termini of proteins stabilize charges. Proc Natl Acad Sci U S A. 1991 Mar 01; 88(5):2026-30.Proc Natl Acad Sci U S A1991-03-01T00:00:001991Dipoles localized at helix termini of proteins stabilize charges.2002055Jacobson BL, He JJ, Vermersch PS, Lemon DD, Quiocho FAThe Journal of biological chemistryEngineered interdomain disulfide in the periplasmic receptor for sulfate transport reduces flexibility. Site-directed mutagenesis and ligand-binding studies. J Biol Chem. 1991 Mar 15; 266(8):5220-5.J Biol Chem1991-03-15T00:00:001991Engineered interdomain disulfide in the periplasmic receptor for sulfate transport reduces flexibility. Site-directed mutagenesis and ligand-binding studies.18059263Lee YS, Huang K, Quiocho FA, O'Shea EKNature chemical biologyMolecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphate. Nat Chem Biol. 2008 Jan; 4(1):25-32.Nat Chem Biol2007-11-25T00:00:002007Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphate.18488309Sack JS, Quiocho FAMethods in enzymologyCHAIN: a crystallographic modeling program. Methods Enzymol. 1997; 277:158-73.Methods Enzymol1997-01-01T00:00:001997CHAIN: a crystallographic modeling program.KRISTENKARLINKRISTEN KARLIN0.000000000000000.000000000000004913KARLIN, KRISTENAssistant Professor1695249Vyas MN, Vyas NK, Liou RS, Chang TW, Quiocho FAJournal of molecular biologyPreliminary crystallographic analysis of the Fab fragment of an antibody against HIV gp120. J Mol Biol. 1990 Jul 05; 214(1):23-4.J Mol Biol1990-07-05T00:00:001990Preliminary crystallographic analysis of the Fab fragment of an antibody against HIV gp120.14527397Fallon JL, Quiocho FAStructure (London, England : 1993)A closed compact structure of native Ca(2+)-calmodulin. Structure. 2003 Oct; 11(10):1303-7.Structure2003-10-01T00:00:002003A closed compact structure of native Ca(2+)-calmodulin.14527411Chen J, Lu G, Lin J, Davidson AL, Quiocho FAMolecular cellA tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle. Mol Cell. 2003 Sep; 12(3):651-61.Mol Cell2003-09-01T00:00:002003A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle.19279214Fallon JL, Baker MR, Xiong L, Loy RE, Yang G, Dirksen RT, Hamilton SL, Quiocho FAProceedings of the National Academy of Sciences of the United States of AmericaCrystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5135-40.Proc Natl Acad Sci U S A2009-03-11T00:00:002009Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins.2196376Martineau P, Szmelcman S, Spurlino JC, Quiocho FA, Hofnung MJournal of molecular biologyGenetic approach to the role of tryptophan residues in the activities and fluorescence of a bacterial periplasmic maltose-binding protein. J Mol Biol. 1990 Jul 05; 214(1):337-52.J Mol Biol1990-07-05T00:00:001990Genetic approach to the role of tryptophan residues in the activities and fluorescence of a bacterial periplasmic maltose-binding protein.2204627Vermersch PS, Tesmer JJ, Lemon DD, Quiocho FAThe Journal of biological chemistryA Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies. J Biol Chem. 1990 Sep 25; 265(27):16592-603.J Biol Chem1990-09-25T00:00:001990A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.20000741Vyas NK, Nickitenko A, Rastogi VK, Shah SS, Quiocho FABiochemistryStructural insights into the dual activities of the nerve agent degrading organophosphate anhydrolase/prolidase. Biochemistry. 2010 Jan 26; 49(3):547-59.Biochemistry2010-01-26T00:00:002010Structural insights into the dual activities of the nerve agent degrading organophosphate anhydrolase/prolidase.20016007He B, Yu X, Margolis M, Liu X, Leng X, Etzion Y, Zheng F, Lu N, Quiocho FA, Danino D, Zhou ZMolecular biology of the cellLive-cell imaging in Caenorhabditis elegans reveals the distinct roles of dynamin self-assembly and guanosine triphosphate hydrolysis in the removal of apoptotic cells. Mol Biol Cell. 2010 Feb 15; 21(4):610-29.Mol Biol Cell2009-12-16T00:00:002009Live-cell imaging in Caenorhabditis elegans reveals the distinct roles of dynamin self-assembly and guanosine triphosphate hydrolysis in the removal of apoptotic cells.15507492Chakravarty B, Gu Z, Chirala SS, Wakil SJ, Quiocho FAProceedings of the National Academy of Sciences of the United States of AmericaHuman fatty acid synthase: structure and substrate selectivity of the thioesterase domain. Proc Natl Acad Sci U S A. 2004 Nov 02; 101(44):15567-72.Proc Natl Acad Sci U S A2004-10-26T00:00:002004Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain.1782354Wade RC, Mazor MH, McCammon JA, Quiocho FABiopolymersA molecular dynamics study of thermodynamic and structural aspects of the hydration of cavities in proteins. Biopolymers. 1991 Jul; 31(8):919-31.Biopolymers1991-07-01T00:00:001991A molecular dynamics study of thermodynamic and structural aspects of the hydration of cavities in proteins.16474137Bowman BR, Welschhans RL, Jayaram H, Stow ND, Preston VG, Quiocho FAJournal of virologyStructural characterization of the UL25 DNA-packaging protein from herpes simplex virus type 1. J Virol. 2006 Mar; 80(5):2309-17.J Virol2006-03-01T00:00:002006Structural characterization of the UL25 DNA-packaging protein from herpes simplex virus type 1.1925539Wilson DK, Rudolph FB, Quiocho FAScience (New York, N.Y.)Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations. Science. 1991 May 31; 252(5010):1278-84.Science1991-05-31T00:00:001991Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations.21787787Srinivasan S, Vyas NK, Baker ML, Quiocho FAJournal of molecular biologyCrystal structure of the cytoplasmic N-terminal domain of subunit I, a homolog of subunit a, of V-ATPase. J Mol Biol. 2011 Sep 09; 412(1):14-21.J Mol Biol2011-07-22T00:00:002011Crystal structure of the cytoplasmic N-terminal domain of subunit I, a homolog of subunit a, of V-ATPase.1939171Taylor DA, Sack JS, Maune JF, Beckingham K, Quiocho FAThe Journal of biological chemistryStructure of a recombinant calmodulin from Drosophila melanogaster refined at 2.2-A resolution. J Biol Chem. 1991 Nov 15; 266(32):21375-80.J Biol Chem1991-11-15T00:00:001991Structure of a recombinant calmodulin from Drosophila melanogaster refined at 2.2-A resolution.15850393Trakhanov S, Vyas NK, Luecke H, Kristensen DM, Ma J, Quiocho FABiochemistryLigand-free and -bound structures of the binding protein (LivJ) of the Escherichia coli ABC leucine/isoleucine/valine transport system: trajectory and dynamics of the interdomain rotation and ligand specificity. Biochemistry. 2005 May 03; 44(17):6597-608.Biochemistry2005-05-03T00:00:002005Ligand-free and -bound structures of the binding protein (LivJ) of the Escherichia coli ABC leucine/isoleucine/valine transport system: trajectory and dynamics of the interdomain rotation and ligand specificity.22496448Finnigan GC, Cronan GE, Park HJ, Srinivasan S, Quiocho FA, Stevens THThe Journal of biological chemistrySorting of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase): identification of a necessary and sufficient Golgi/endosomal retention signal in Stv1p. J Biol Chem. 2012 Jun 01; 287(23):19487-500.J Biol Chem2012-04-11T00:00:002012Sorting of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase): identification of a necessary and sufficient Golgi/endosomal retention signal in Stv1p.1900953He JJ, Quiocho FAScience (New York, N.Y.)A nonconservative serine to cysteine mutation in the sulfate-binding protein, a transport receptor. Science. 1991 Mar 22; 251(5000):1479-81.Science1991-03-22T00:00:001991A nonconservative serine to cysteine mutation in the sulfate-binding protein, a transport receptor.16591584Reeke GN, Hartsuck JA, Ludwig ML, Quiocho FA, Steitz TA, Lipscomb WNProceedings of the National Academy of Sciences of the United States of AmericaThe structure of carboxypeptidase a, vi. Some results at 2.0-a resolution, and the complex with glycyl-tyrosine at 2.8-a resolution. Proc Natl Acad Sci U S A. 1967 Dec; 58(6):2220-6.Proc Natl Acad Sci U S A1967-12-01T00:00:001967The structure of carboxypeptidase a, vi. Some results at 2.0-a resolution, and the complex with glycyl-tyrosine at 2.8-a resolution.2002054Spurlino JC, Lu GY, Quiocho FAThe Journal of biological chemistryThe 2.3-A resolution structure of the maltose- or maltodextrin-binding protein, a primary receptor of bacterial active transport and chemotaxis. J Biol Chem. 1991 Mar 15; 266(8):5202-19.J Biol Chem1991-03-15T00:00:001991The 2.3-A resolution structure of the maltose- or maltodextrin-binding protein, a primary receptor of bacterial active transport and chemotaxis.17470791Poon BK, Chen X, Lu M, Vyas NK, Quiocho FA, Wang Q, Ma JProceedings of the National Academy of Sciences of the United States of AmericaNormal mode refinement of anisotropic thermal parameters for a supramolecular complex at 3.42-A crystallographic resolution. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):7869-74.Proc Natl Acad Sci U S A2007-04-30T00:00:002007Normal mode refinement of anisotropic thermal parameters for a supramolecular complex at 3.42-A crystallographic resolution.17847090Cheng F, Wang Q, Chen M, Quiocho FA, Ma JProteinsMolecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands. Proteins. 2008 Mar; 70(4):1228-34.Proteins2008-03-01T00:00:002008Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands.18033289Oldham ML, Khare D, Quiocho FA, Davidson AL, Chen JNatureCrystal structure of a catalytic intermediate of the maltose transporter. Nature. 2007 Nov 22; 450(7169):515-21.Nature2007-11-22T00:00:002007Crystal structure of a catalytic intermediate of the maltose transporter.2069949Vermersch PS, Lemon DD, Tesmer JJ, Quiocho FABiochemistrySugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity. Biochemistry. 1991 Jul 16; 30(28):6861-6.Biochemistry1991-07-16T00:00:001991Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity.2124143Martineau P, Saurin W, Hofnung M, Spurlino JC, Quiocho FABiochimieProgress in the identification of interaction sites on the periplasmic maltose binding protein from E coli. Biochimie. 1990 Jun-Jul; 72(6-7):397-402.Biochimie1990-06-01T00:00:001990Progress in the identification of interaction sites on the periplasmic maltose binding protein from E coli.18424798Moure CM, Gimble FS, Quiocho FANucleic acids researchCrystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway. Nucleic Acids Res. 2008 Jun; 36(10):3287-96.Nucleic Acids Res2008-04-19T00:00:002008Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway.2215649Luecke H, Quiocho FANatureHigh specificity of a phosphate transport protein determined by hydrogen bonds. Nature. 1990 Sep 27; 347(6291):402-6.Nature1990-09-27T00:00:001990High specificity of a phosphate transport protein determined by hydrogen bonds.20664542Firozi P, Zhang W, Chen L, Quiocho FA, Worley KC, Templeton NSGene therapyIdentification and removal of colanic acid from plasmid DNA preparations: implications for gene therapy. Gene Ther. 2010 Dec; 17(12):1484-99.Gene Ther2010-07-22T00:00:002010Identification and removal of colanic acid from plasmid DNA preparations: implications for gene therapy.Authorship 1010895Authorship 101333521908709Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ, Quiocho FAProceedings of the National Academy of Sciences of the United States of AmericaCrystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15757-62.Proc Natl Acad Sci U S A2011-09-09T00:00:002011Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid.23591871Alpadi K, Kulkarni A, Namjoshi S, Srinivasan S, Sippel KH, Ayscough K, Zieger M, Schmidt A, Mayer A, Evangelista M, Quiocho FA, Peters CNature communicationsDynamin-SNARE interactions control trans-SNARE formation in intracellular membrane fusion. Nat Commun. 2013; 4:1704.Nat Commun2013-01-01T00:00:002013Dynamin-SNARE interactions control trans-SNARE formation in intracellular membrane fusion.2715729Kim HS, Wilson WK, Needleman DH, Pinkerton FD, Wilson DK, Quiocho FA, Schroepfer GJJournal of lipid researchInhibitors of sterol synthesis. Chemical synthesis, structure, and biological activities of (25R)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-en-15-one, a metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one. J Lipid Res. 1989 Feb; 30(2):247-61.J Lipid Res1989-02-01T00:00:001989Inhibitors of sterol synthesis. Chemical synthesis, structure, and biological activities of (25R)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-en-15-one, a metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one.326785Quiocho FA, Gilliland GL, Phillips GNThe Journal of biological chemistryThe 2.8-A resolution structure of the L-arabinose-binding protein from Escherichia coli. Polypeptide chain folding, domain similarity, and probable location of sugar-binding site. J Biol Chem. 1977 Jul 25; 252(14):5142-9.J Biol Chem1977-07-25T00:00:001977The 2.8-A resolution structure of the L-arabinose-binding protein from Escherichia coli. Polypeptide chain folding, domain similarity, and probable location of sugar-binding site.23209439Huang Z, Srinivasan S, Zhang J, Chen K, Li Y, Li W, Quiocho FA, Pan XPLoS geneticsDiscovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy. PLoS Genet. 2012; 8(11):e1003083.PLoS Genet2012-11-29T00:00:002012Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy.2649682Sack JS, Saper MA, Quiocho FAJournal of molecular biologyPeriplasmic binding protein structure and function. Refined X-ray structures of the leucine/isoleucine/valine-binding protein and its complex with leucine. J Mol Biol. 1989 Mar 05; 206(1):171-91.J Mol Biol1989-03-05T00:00:001989Periplasmic binding protein structure and function. Refined X-ray structures of the leucine/isoleucine/valine-binding protein and its complex with leucine.395320Beissner RS, Quiocho FA, Rudolph FBJournal of molecular biologyDinucleotide fold proteins. Interaction of arabinose binding protein with Cibacron Blue 3G-A. J Mol Biol. 1979 Nov 15; 134(4):847-50.J Mol Biol1979-11-15T00:00:001979Dinucleotide fold proteins. Interaction of arabinose binding protein with Cibacron Blue 3G-A.3058393Quiocho FACurrent topics in microbiology and immunologyMolecular features and basic understanding of protein-carbohydrate interactions: the arabinose-binding protein-sugar complex. Curr Top Microbiol Immunol. 1988; 139:135-48.Curr Top Microbiol Immunol1988-01-01T00:00:001988Molecular features and basic understanding of protein-carbohydrate interactions: the arabinose-binding protein-sugar complex.3191559Wilson DK, Wilson WK, Quiocho FA, Schroepfer GJChemistry and physics of lipidsConcerning the structure of 3 beta-benzoyloxy-5 beta-cholesta-8,14-diene, a major byproduct in the chemical synthesis of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one. Chem Phys Lipids. 1988 Aug; 47(4):273-82.Chem Phys Lipids1988-08-01T00:00:001988Concerning the structure of 3 beta-benzoyloxy-5 beta-cholesta-8,14-diene, a major byproduct in the chemical synthesis of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one.3454273Quiocho FA, Vyas NK, Sack JS, Vyas MNCold Spring Harbor symposia on quantitative biologyAtomic protein structures reveal basic features of binding of sugars and ionic substrates, and calcium cation. Cold Spring Harb Symp Quant Biol. 1987; 52:453-63.Cold Spring Harb Symp Quant Biol1987-01-01T00:00:001987Atomic protein structures reveal basic features of binding of sugars and ionic substrates, and calcium cation.3600760Vyas NK, Vyas MN, Quiocho FANatureA novel calcium binding site in the galactose-binding protein of bacterial transport and chemotaxis. Nature. 1987 Jun 18-24; 327(6123):635-8.Nature1987-06-01T00:00:001987A novel calcium binding site in the galactose-binding protein of bacterial transport and chemotaxis.4399045Lipscomb WN, Reeke GN, Hartsuck JA, Quiocho FA, Bethge PHPhilosophical transactions of the Royal Society of London. Series B, Biological sciencesThe structure of carboxypeptidase A. 8. Atomic interpretation at 0.2 nm resolution, a new study of the complex of glycyl-L-tyrosine with CPA, and mechanistic deductions. Philos Trans R Soc Lond B Biol Sci. 1970 Feb 12; 257(813):177-214.Philos Trans R Soc Lond B Biol Sci1970-02-12T00:00:001970The structure of carboxypeptidase A. 8. Atomic interpretation at 0.2 nm resolution, a new study of the complex of glycyl-L-tyrosine with CPA, and mechanistic deductions.4507609Quiocho FA, McMurray CH, Lipscomb WNProceedings of the National Academy of Sciences of the United States of AmericaSimilarities between the conformation of arsanilazotyrosine 248 of carboxypeptidase A in the crystalline state and in solution. Proc Natl Acad Sci U S A. 1972 Oct; 69(10):2850-4.Proc Natl Acad Sci U S A1972-10-01T00:00:001972Similarities between the conformation of arsanilazotyrosine 248 of carboxypeptidase A in the crystalline state and in solution.4946703Quiocho FA, Lipscomb WNAdvances in protein chemistryCarboxypeptidase A: a protein and an enzyme. Adv Protein Chem. 1971; 25:1-78.Adv Protein Chem1971-01-01T00:00:001971Carboxypeptidase A: a protein and an enzyme.5288772Quiocho FA, Reeke GN, Becker JW, Lipscomb WN, Edelman GMProceedings of the National Academy of Sciences of the United States of AmericaStructure of soncanavalin A at 4 A resolution. Proc Natl Acad Sci U S A. 1971 Aug; 68(8):1853-7.Proc Natl Acad Sci U S A1971-08-01T00:00:001971Structure of soncanavalin A at 4 A resolution.6355105Fukada H, Sturtevant JM, Quiocho FAThe Journal of biological chemistryThermodynamics of the binding of L-arabinose and of D-galactose to the L-arabinose-binding protein of Escherichia coli. J Biol Chem. 1983 Nov 10; 258(21):13193-8.J Biol Chem1983-11-10T00:00:001983Thermodynamics of the binding of L-arabinose and of D-galactose to the L-arabinose-binding protein of Escherichia coli.718720Schroepfer GJ, Parish EJ, Gilliland GL, Newcomer ME, Sommerville LL, Quiocho FA, Kandutsch AABiochemical and biophysical research communications7alpha, 15beta-Dichloro-5alpha-cholest-8 (14)-en-3beta-ol, a novel inhibitor of sterol biosynthesis in animal cells. Biochem Biophys Res Commun. 1978 Oct 16; 84(3):823-9.Biochem Biophys Res Commun1978-10-16T00:00:0019787alpha, 15beta-Dichloro-5alpha-cholest-8 (14)-en-3beta-ol, a novel inhibitor of sterol biosynthesis in animal cells.6462229Sams CF, Vyas NK, Quiocho FA, Matthews KSNaturePredicted structure of the sugar-binding site of the lac repressor. Nature. 1984 Aug 2-8; 310(5976):429-30.Nature1984-08-01T00:00:001984Predicted structure of the sugar-binding site of the lac repressor.828701Quiocho FAMethods in enzymologyImmobilized proteins in single crystals. Methods Enzymol. 1976; 44:546-58.Methods Enzymol1976-01-01T00:00:001976Immobilized proteins in single crystals.7583665Meador WE, George SE, Means AR, Quiocho FANature structural biologyX-ray analysis reveals conformational adaptation of the linker in functional calmodulin mutants. Nat Struct Biol. 1995 Nov; 2(11):943-5.Nat Struct Biol1995-11-01T00:00:001995X-ray analysis reveals conformational adaptation of the linker in functional calmodulin mutants.Authorship 102425Authorship 10254028161536Yao N, Trakhanov S, Quiocho FABiochemistryRefined 1.89-A structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport/chemosensory proteins. Biochemistry. 1994 Apr 26; 33(16):4769-79.Biochemistry1994-04-26T00:00:001994Refined 1.89-A structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport/chemosensory proteins.8183265Kochkina VM, Korolev SV, Meador WE, Wilson D, Quiocho FA, Kuzin APMolekuliarnaia biologiia[Study of crystals of aspartate aminotransferase complexed with D-aspartate]. Mol Biol (Mosk). 1994 Mar-Apr; 28(2):333-41.Mol Biol (Mosk)1994-03-01T00:00:001994[Study of crystals of aspartate aminotransferase complexed with D-aspartate].Authorship 1031548399200Sharff AJ, Rodseth LE, Quiocho FABiochemistryRefined 1.8-A structure reveals the mode of binding of beta-cyclodextrin to the maltodextrin binding protein. Biochemistry. 1993 Oct 12; 32(40):10553-9.Biochemistry1993-10-12T00:00:001993Refined 1.8-A structure reveals the mode of binding of beta-cyclodextrin to the maltodextrin binding protein.8612277Hodel AE, Gershon PD, Shi X, Quiocho FACellThe 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends. Cell. 1996 Apr 19; 85(2):247-56.Cell1996-04-19T00:00:001996The 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends.8691741Quiocho FAKidney internationalAtomic basis of the exquisite specificity of phosphate and sulfate transport receptors. Kidney Int. 1996 Apr; 49(4):943-6.Kidney Int1996-04-01T00:00:001996Atomic basis of the exquisite specificity of phosphate and sulfate transport receptors.8861200Quiocho FA, Ledvina PSMolecular microbiologyAtomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: variation of common themes. Mol Microbiol. 1996 Apr; 20(1):17-25.Mol Microbiol1996-04-01T00:00:001996Atomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: variation of common themes.8942668Sideraki V, Wilson DK, Kurz LC, Quiocho FA, Rudolph FBBiochemistrySite-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation. Biochemistry. 1996 Nov 26; 35(47):15019-28.Biochemistry1996-11-26T00:00:001996Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation.9160747Duan X, Gimble FS, Quiocho FACellCrystal structure of PI-SceI, a homing endonuclease with protein splicing activity. Cell. 1997 May 16; 89(4):555-64.Cell1997-05-16T00:00:001997Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity.9228942Wang Z, Luecke H, Yao N, Quiocho FANature structural biologyA low energy short hydrogen bond in very high resolution structures of protein receptor--phosphate complexes. Nat Struct Biol. 1997 Jul; 4(7):519-22.Nat Struct Biol1997-07-01T00:00:001997A low energy short hydrogen bond in very high resolution structures of protein receptor--phosphate complexes.9660928Hodel AE, Gershon PD, Quiocho FAMolecular cellStructural basis for sequence-nonspecific recognition of 5'-capped mRNA by a cap-modifying enzyme. Mol Cell. 1998 Feb; 1(3):443-7.Mol Cell1998-02-01T00:00:001998Structural basis for sequence-nonspecific recognition of 5'-capped mRNA by a cap-modifying enzyme.10644733Hu D, Crist M, Duan X, Quiocho FA, Gimble FSThe Journal of biological chemistryProbing the structure of the PI-SceI-DNA complex by affinity cleavage and affinity photocross-linking. J Biol Chem. 2000 Jan 28; 275(4):2705-12.J Biol Chem2000-01-28T00:00:002000Probing the structure of the PI-SceI-DNA complex by affinity cleavage and affinity photocross-linking.11171984Chen J, Sharma S, Quiocho FA, Davidson ALProceedings of the National Academy of Sciences of the United States of AmericaTrapping the transition state of an ATP-binding cassette transporter: evidence for a concerted mechanism of maltose transport. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1525-30.Proc Natl Acad Sci U S A2001-02-06T00:00:002001Trapping the transition state of an ATP-binding cassette transporter: evidence for a concerted mechanism of maltose transport.1519061Meador WE, Means AR, Quiocho FAScience (New York, N.Y.)Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex. Science. 1992 Aug 28; 257(5074):1251-5.Science1992-08-28T00:00:001992Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex.11875510Meador WE, Quiocho FANature structural biologyMan bites dog. Nat Struct Biol. 2002 Mar; 9(3):156-8.Nat Struct Biol2002-03-01T00:00:002002Man bites dog.14645714Vyas NK, Vyas MN, Chervenak MC, Bundle DR, Pinto BM, Quiocho FAProceedings of the National Academy of Sciences of the United States of AmericaStructural basis of peptide-carbohydrate mimicry in an antibody-combining site. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15023-8.Proc Natl Acad Sci U S A2003-11-25T00:00:002003Structural basis of peptide-carbohydrate mimicry in an antibody-combining site.15272307Mao Y, Vyas NK, Vyas MN, Chen DH, Ludtke SJ, Chiu W, Quiocho FAThe EMBO journalStructure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer. EMBO J. 2004 Aug 04; 23(15):2963-71.EMBO J2004-07-22T00:00:002004Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer.15522285Cushman I, Bowman BR, Sowa ME, Lichtarge O, Quiocho FA, Moore MSJournal of molecular biologyComputational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2. J Mol Biol. 2004 Nov 19; 344(2):303-10.J Mol Biol2004-11-19T00:00:002004Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2.Authorship 1049684Authorship 103780517933871Zhang W, Wang D, Volk E, Bellen HJ, Hiesinger PR, Quiocho FAThe Journal of biological chemistryV-ATPase V0 sector subunit a1 in neurons is a target of calmodulin. J Biol Chem. 2008 Jan 04; 283(1):294-300.J Biol Chem2007-10-12T00:00:002007V-ATPase V0 sector subunit a1 in neurons is a target of calmodulin.18805831Elizondo LI, Cho KS, Zhang W, Yan J, Huang C, Huang Y, Choi K, Sloan EA, Deguchi K, Lou S, Baradaran-Heravi A, Takashima H, L?cke T, Quiocho FA, Boerkoel CFJournal of medical geneticsSchimke immuno-osseous dysplasia: SMARCAL1 loss-of-function and phenotypic correlation. J Med Genet. 2009 Jan; 46(1):49-59.J Med Genet2008-09-19T00:00:002008Schimke immuno-osseous dysplasia: SMARCAL1 loss-of-function and phenotypic correlation.19473981Halling DB, Georgiou DK, Black DJ, Yang G, Fallon JL, Quiocho FA, Pedersen SE, Hamilton SLThe Journal of biological chemistryDeterminants in CaV1 channels that regulate the Ca2+ sensitivity of bound calmodulin. J Biol Chem. 2009 Jul 24; 284(30):20041-51.J Biol Chem2009-05-27T00:00:002009Determinants in CaV1 channels that regulate the Ca2+ sensitivity of bound calmodulin.Authorship 10606352649683Sack JS, Trakhanov SD, Tsigannik IH, Quiocho FAJournal of molecular biologyStructure of the L-leucine-binding protein refined at 2.4 A resolution and comparison with the Leu/Ile/Val-binding protein structure. J Mol Biol. 1989 Mar 05; 206(1):193-207.J Mol Biol1989-03-05T00:00:001989Structure of the L-leucine-binding protein refined at 2.4 A resolution and comparison with the Leu/Ile/Val-binding protein structure.2684986Vyas MN, Jacobson BL, Quiocho FAThe Journal of biological chemistryThe calcium-binding site in the galactose chemoreceptor protein. Crystallographic and metal-binding studies. J Biol Chem. 1989 Dec 05; 264(34):20817-21.J Biol Chem1989-12-05T00:00:001989The calcium-binding site in the galactose chemoreceptor protein. Crystallographic and metal-binding studies.true1ProfessorProfessorAuthorship 1019874D002352Chemicals & Drugs76820300.532882Carrier ProteinsD018360Procedures1726260.854494Crystallography, X-RayD029968Chemicals & Drugs993580.792093Escherichia coli ProteinsD001426Chemicals & Drugs29610280.630974Bacterial ProteinsAuthorship 1083433D033902Chemicals & Drugs5370.984224Periplasmic Binding ProteinsAuthorship 1043101Authorship 10925832009-03-31NIHQUIOCHO, FLORANTE A2004-04-01FATTY ACID SYNTHASE: STRUCTURE, DYNAMICS AND FUNCTIONR01GM0688262012-08-31NIHQUIOCHO, FLORANTE A2009-09-21Molecular Studies of the Roles and Regulations of the v-ATPase V0 SectorR01GM0888032008-04-30NIHQUIOCHO, FLORANTE A1977-12-01ABC Transport Components: Structures and FunctionsR01GM021371Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorDepartment of MedicineDepartment of Molecular & Cellular BiologyDepartment of Molecular & Human GeneticsDepartment of RadiologyRadiologyMedicine-Gastroenterology & HepatolMolecular & Cellular BiologyMolecular & Human GeneticsMolecular Physiology & BiophysicsBaylor College of MedicineYONGCHENGSONGYONGCHENG SONG0.000000000000000.000000000000001486SONG, YONGCHENGProfessorJAMESCROWEJAMES CROWE0.000000000000000.000000000000001560CROWE, JAMESAssociate Professor3.531810.000842997511research areas0.1774960.016340711coauthor of116.4689.2078260similar to11187selected publicationsSUKYEONGLEESUKYEONG LEE0.000000000000000.00000000000000262LEE, SUKYEONGAssociate ProfessorTHEODOREWENSELTHEODORE WENSEL0.000000000000000.000000000000003220WENSEL, THEODOREProfessorAuthorship 1091602YOSHIOYAMAOKAYOSHIO YAMAOKA0.000000000000000.000000000000003531YAMAOKA, YOSHIOProfessorHUGOBELLENHUGO BELLEN29.71010310000000-95.397396100000003292BELLEN, HUGODistinguished Service ProfessorSUSANROSENBERGSUSAN ROSENBERG29.70508570000000-95.401808700000003545ROSENBERG, SUSANProfessorAuthorship 1092321SUNGJUNGSUNG JUNG0.000000000000000.000000000000004156JUNG, SUNGAssociate ProfessorAuthorship 1105487SUSANHAMILTONSUSAN HAMILTON0.000000000000000.0000000000000028HAMILTON, SUSANProfessorJIANQIANGMAOJIANQIANG MAO0.000000000000000.00000000000000296MAO, JIANQIANGInstructorTIMOTHYPALZKILLTIMOTHY PALZKILL0.000000000000000.000000000000003364PALZKILL, TIMOTHYChairANTHONYMEANSANTHONY MEANS39.09225730000000-77.209617300000004183MEANS, ANTHONYProfessorSTEVENLUDTKESTEVEN LUDTKE0.000000000000000.0000000000000049LUDTKE, STEVENProfessorAuthorship 1094001Authorship 106291Authorship 1100923Authorship 129153224022486Zheng F, Quiocho FAThe Journal of biological chemistryNew structural insights into phosphorylation-free mechanism for full cyclin-dependent kinase (CDK)-cyclin activity and substrate recognition. J Biol Chem. 2013 Oct 18; 288(42):30682-30692.J Biol Chem2013-09-10T00:00:002013New structural insights into phosphorylation-free mechanism for full cyclin-dependent kinase (CDK)-cyclin activity and substrate recognition.Authorship 1067874Authorship 1085174Authorship 1138235true1ProfessorProfessortrue1Associate ProfessorAssociate ProfessorAuthorship 1134178Authorship 1113614Authorship 1139053Authorship 1119259Authorship 1173373http://flypush.imgen.bcm.tmc.eduBellen Lab WebsiteAuthorship 1124004Authorship 1142463Authorship 1145126Authorship 1192213Authorship 1200321Authorship 1137672Authorship 1211321Authorship 1168574Authorship 1151692true1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 1169887Authorship 1203693true1ProfessorProfessorDepartment of Integrative PhysiologyAuthorship 169201Authorship 1225085true1InstructorInstructorAuthorship 125724Authorship 131355true1Distinguished Emeritus ProfessorDistinguished Emeritus Professortrue1ChairChairtrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessorDepartment of Biochemistry and Molecular PharmacologyBiochemistry & Mol Pharmacologytrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessorAuthorship 197406Authorship 208906Authorship 176053true1ProfessorProfessorAuthorship 20543Authorship 221881Authorship 190946Authorship 204147Authorship 24954Authorship 215035Authorship 254103Authorship 222485Authorship 318217Authorship 321665Authorship 325352Authorship 347653Authorship 245874Authorship 257211Authorship 26933Authorship 390924Authorship 408052Authorship 4594Authorship 142690724733584Wang D, Epstein D, Khalaf O, Srinivasan S, Williamson WR, Fayyazuddin A, Quiocho FA, Hiesinger PRThe Journal of cell biologyCa2+-Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1. J Cell Biol. 2014 Apr 14; 205(1):21-31.J Cell Biol2014-04-14T00:00:002014Ca2+-Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1.Authorship 466638Authorship 329177Authorship 318945Authorship 334334Authorship 342931Authorship 506902Authorship 366433Authorship 381926Authorship 369903Authorship 38738Authorship 556791Authorship 38562Authorship 409794Authorship 145827324915101Sippel KH, Bacik J, Quiocho FA, Fisher SZActa crystallographica. Section F, Structural biology communicationsPreliminary time-of-flight neutron diffraction studies of Escherichia coli ABC transport receptor phosphate-binding protein at the Protein Crystallography Station. Acta Crystallogr F Struct Biol Commun. 2014 Jun; 70(Pt 6):819-22.Acta Crystallogr F Struct Biol Commun2014-05-25T00:00:002014Preliminary time-of-flight neutron diffraction studies of Escherichia coli ABC transport receptor phosphate-binding protein at the Protein Crystallography Station.Authorship 432785Authorship 434514Authorship 422521Authorship 636863Authorship 462985Authorship 642211Authorship 473806Authorship 477331Authorship 499731Authorship 506884Authorship 513934Authorship 719664Authorship 515333Authorship 515753Authorship 527063Authorship 528274Authorship 531093Authorship 737056Authorship 536073Authorship 540825Authorship 542788Authorship 558462Authorship 560205Authorship 819104Authorship 575842Authorship 582605Authorship 589304Authorship 602493Authorship 612633Authorship 852843Authorship 617913Authorship 665311Authorship 666026Authorship 653844Authorship 654782Authorship 664554Authorship 954775Authorship 67213Authorship 674603Authorship 694921Authorship 690723Authorship 695102Authorship 709334Authorship 727752Authorship 722544Authorship 742204Authorship 74953Authorship 770693Authorship 1556185