MARTAFIOROTTOMARTA FIOROTTO0.000000000000000.000000000000002894FIOROTTO, MARTADevelopmental programmingMuscle BiologyMalnutrition in InfantsProtein and energy metabolismPediatric NutririonBody CompositionExerciseMuscular Dystrophy, Duchenne-BeckerThe major objective of the research in my lab is to identify the mechanisms that underlie the effects of nutrient intake on the growth and function of skeletal muscle. In the perinatal period, skeletal muscle is the fastest growing protein pool in the body and is highly dependent on nutrient supply and the ability to use dietary nutrients efficiently. Thus, one of my research interests is to understand how nutrients regulate the primary anabolic processes responsible for muscle growth, i.e., protein synthesis and satellite cell replication during this period. Recently, this has extended to research on the consequences of Duchenne Muscular Dystrophy for skeletal muscle and whole body protein metabolism with the goal of identifying the contribution of protein and energy intakes on the progression of the disease, especially in its early stages.
A second research interest is rooted in the observation that a brief period of growth retardation during a critical period of development results in a lifelong deficit in muscle mass and exercise capacity. We are conducting research to understand why this happens and to identify interventions that can reverse the muscle deficit and improve exercise performance.
We perform studies using the mouse and the newborn piglet as animal models, together with a wide array of techniques including in vivo tracer kinetics, in vivo metabolic measurements, an assortment of molecular biology techniques, microscopy, cell culture, and muscle physiology measurements to address these research questions.Associate Professorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:degreeEarneddegree earnedDepartmentDivisionvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:majorFieldmajor field of degreevivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 156600125239457Fiorotto ML, Davis TA, Sosa HA, Villegas-Montoya C, Estrada I, Fleischmann RThe Journal of physiologyRibosome abundance regulates the recovery of skeletal muscle protein mass upon recuperation from postnatal undernutrition in mice. J Physiol. 2014 Dec 01; 592(23):5269-86.J Physiol2014-09-19T00:00:002014Ribosome abundance regulates the recovery of skeletal muscle protein mass upon recuperation from postnatal undernutrition in mice.25474017Davis TA, Fiorotto ML, Suryawan ACurrent opinion in clinical nutrition and metabolic careBolus vs. continuous feeding to optimize anabolism in neonates. Curr Opin Clin Nutr Metab Care. 2015 Jan; 18(1):102-8.Curr Opin Clin Nutr Metab Care2015-01-01T00:00:002015Bolus vs. continuous feeding to optimize anabolism in neonates.Authorship 817274Authorship 811695Authorship 876472Authorship 90312221779306Davis TA, Suryawan A, Orellana RA, Fiorotto ML, Burrin DGAnimal : an international journal of animal bioscienceAmino acids and insulin are regulators of muscle protein synthesis in neonatal pigs. Animal. 2010; 4(11):1790-1796.Animal2010-01-01T00:00:002010Amino acids and insulin are regulators of muscle protein synthesis in neonatal pigs.Authorship 896023Authorship 900375Authorship 925144Authorship 923118Authorship 923771Authorship 969904Authorship 1006744Authorship 1013622Authorship 1035272Authorship 1100723Authorship 1110063Authorship 1110674Authorship 1111224Authorship 120036Authorship 250003Authorship 161618225408462Columbus DA, Fiorotto ML, Davis TAAmino acidsLeucine is a major regulator of muscle protein synthesis in neonates. Amino Acids. 2015 Feb; 47(2):259-70.Amino Acids2014-11-20T00:00:002014Leucine is a major regulator of muscle protein synthesis in neonates.Authorship 363131Authorship 39931Authorship 409766Authorship 464762Authorship 501021Authorship 517527Authorship 527778Authorship 75953Authorship 874832Authorship 9394932912007Cochran WJ, Fiorotto ML, Sheng HP, Klish WJThe American journal of clinical nutritionReliability of fat-free mass estimates derived from total-body electrical conductivity measurements as influenced by changes in extracellular fluid volume. Am J Clin Nutr. 1989 Jan; 49(1):29-32.Am J Clin Nutr1989-01-01T00:00:001989Reliability of fat-free mass estimates derived from total-body electrical conductivity measurements as influenced by changes in extracellular fluid volume.3048079Cochran WJ, Wong WW, Fiorotto ML, Sheng HP, Klein PD, Klish WJThe American journal of clinical nutritionTotal body water estimated by measuring total-body electrical conductivity. Am J Clin Nutr. 1988 Oct; 48(4):946-50.Am J Clin Nutr1988-10-01T00:00:001988Total body water estimated by measuring total-body electrical conductivity.3110445Shulman RJ, Fiorotto ML, Sheng HP, Finegold MJ, Garza CJPEN. Journal of parenteral and enteral nutritionLiver composition and histology in growing infant miniature pigs given different total parenteral nutrition fuel mixes. JPEN J Parenter Enteral Nutr. 1987 May-Jun; 11(3):275-9.JPEN J Parenter Enteral Nutr1987-05-01T00:00:001987Liver composition and histology in growing infant miniature pigs given different total parenteral nutrition fuel mixes.3289914Wong WW, Cochran WJ, Klish WJ, Smith EO, Lee LS, Fiorotto ML, Klein PDEuropean journal of clinical nutritionBody fat in normal adults estimated by oxygen-18- and deuterium-dilution and by anthropometry: a comparison. Eur J Clin Nutr. 1988 Mar; 42(3):233-42.Eur J Clin Nutr1988-03-01T00:00:001988Body fat in normal adults estimated by oxygen-18- and deuterium-dilution and by anthropometry: a comparison.3585548Fiorotto ML, Sheng HP, Evans HJ, Leblanc AD, Johnson PC, Nichols BLThe Journal of nutritionSpecific effects of weight loss, protein deficiency and energy deprivation on the water and electrolyte composition of young rats. J Nutr. 1987 May; 117(5):933-40.J Nutr1987-05-01T00:00:001987Specific effects of weight loss, protein deficiency and energy deprivation on the water and electrolyte composition of young rats.3684373Fiorotto ML, Cochran WJ, Klish WJPediatric researchFat-free mass and total body water of infants estimated from total body electrical conductivity measurements. Pediatr Res. 1987 Oct; 22(4):417-21.Pediatr Res1987-10-01T00:00:001987Fat-free mass and total body water of infants estimated from total body electrical conductivity measurements.6101889Fiorotto M, Coward WALancet (London, England)Albumin and nutritional oedema. Lancet. 1980 Feb 23; 1(8165):430.Lancet1980-02-23T00:00:001980Albumin and nutritional oedema.6427745Shulman RJ, Fiorotto ML, Sheng HP, Garza CPediatric researchEffect of different total parenteral nutrition fuel mixes on the body composition of infant miniature pigs. Pediatr Res. 1984 Mar; 18(3):261-5.Pediatr Res1984-03-01T00:00:001984Effect of different total parenteral nutrition fuel mixes on the body composition of infant miniature pigs.7700740Fiorotto ML, de Bruin NC, Brans YW, Degenhart HJ, Visser HKPediatric researchTotal body electrical conductivity measurements: an evaluation of current instrumentation for infants. Pediatr Res. 1995 Jan; 37(1):94-100.Pediatr Res1995-01-01T00:00:001995Total body electrical conductivity measurements: an evaluation of current instrumentation for infants.8454555Fiorotto ML, Reeds PJ, Cunningham JJ, Pond WGJournal of animal scienceA semiautomatic device for feeding liquid milk-replacer diets to infant pigs. J Anim Sci. 1993 Jan; 71(1):78-85.J Anim Sci1993-01-01T00:00:001993A semiautomatic device for feeding liquid milk-replacer diets to infant pigs.8368387Davis TA, Fiorotto ML, Nguyen HV, Reeds PJThe American journal of physiologyEnhanced response of muscle protein synthesis and plasma insulin to food intake in suckled rats. Am J Physiol. 1993 Aug; 265(2 Pt 2):R334-40.Am J Physiol1993-08-01T00:00:001993Enhanced response of muscle protein synthesis and plasma insulin to food intake in suckled rats.8487106Davis TA, Fiorotto ML, Reeds PJThe Journal of nutritionAmino acid compositions of body and milk protein change during the suckling period in rats. J Nutr. 1993 May; 123(5):947-56.J Nutr1993-05-01T00:00:001993Amino acid compositions of body and milk protein change during the suckling period in rats.8618147Wykes LJ, Fiorotto M, Burrin DG, Del Rosario M, Frazer ME, Pond WG, Jahoor FThe Journal of nutritionChronic low protein intake reduces tissue protein synthesis in a pig model of protein malnutrition. J Nutr. 1996 May; 126(5):1481-8.J Nutr1996-05-01T00:00:001996Chronic low protein intake reduces tissue protein synthesis in a pig model of protein malnutrition.7603776Burrin DG, Davis TA, Ebner S, Schoknecht PA, Fiorotto ML, Reeds PJ, McAvoy SPediatric researchNutrient-independent and nutrient-dependent factors stimulate protein synthesis in colostrum-fed newborn pigs. Pediatr Res. 1995 May; 37(5):593-9.Pediatr Res1995-05-01T00:00:001995Nutrient-independent and nutrient-dependent factors stimulate protein synthesis in colostrum-fed newborn pigs.114203Fiorotto M, Coward WAThe British journal of nutritionPathogenesis of oedema in protein-energy malnutrition: the significance of plasma colloid osmotic pressure. Br J Nutr. 1979 Jul; 42(1):21-31.Br J Nutr1979-07-01T00:00:001979Pathogenesis of oedema in protein-energy malnutrition: the significance of plasma colloid osmotic pressure.7827005Davis TA, Nguyen HV, Garcia-Bravo R, Fiorotto ML, Jackson EM, Reeds PJThe British journal of nutritionAmino acid composition of the milk of some mammalian species changes with stage of lactation. Br J Nutr. 1994 Dec; 72(6):845-53.Br J Nutr1994-12-01T00:00:001994Amino acid composition of the milk of some mammalian species changes with stage of lactation.8967468Davis TA, Burrin DG, Fiorotto ML, Nguyen HVThe American journal of physiologyProtein synthesis in skeletal muscle and jejunum is more responsive to feeding in 7-than in 26-day-old pigs. Am J Physiol. 1996 May; 270(5 Pt 1):E802-9.Am J Physiol1996-05-01T00:00:001996Protein synthesis in skeletal muscle and jejunum is more responsive to feeding in 7-than in 26-day-old pigs.9176338Fiorotto ML, Davis TAThe American journal of physiologyFood intake alters muscle protein gain with little effect on Na(+)-K(+)-ATPase and myosin isoforms in suckled rats. Am J Physiol. 1997 May; 272(5 Pt 2):R1461-71.Am J Physiol1997-05-01T00:00:001997Food intake alters muscle protein gain with little effect on Na(+)-K(+)-ATPase and myosin isoforms in suckled rats.9331878Burrin DG, Davis TA, Fiorotto ML, Reeds PJJournal of animal scienceRole of milk-borne vs endogenous insulin-like growth factor I in neonatal growth. J Anim Sci. 1997 Oct; 75(10):2739-43.J Anim Sci1997-10-01T00:00:001997Role of milk-borne vs endogenous insulin-like growth factor I in neonatal growth.9176189Davis TA, Fiorotto ML, Burrin DG, Pond WG, Nguyen HVThe American journal of physiologyIntrauterine growth restriction does not alter response of protein synthesis to feeding in newborn pigs. Am J Physiol. 1997 May; 272(5 Pt 1):E877-84.Am J Physiol1997-05-01T00:00:001997Intrauterine growth restriction does not alter response of protein synthesis to feeding in newborn pigs.9478022Davis TA, Burrin DG, Fiorotto ML, Reeds PJ, Jahoor FThe Journal of nutritionRoles of insulin and amino acids in the regulation of protein synthesis in the neonate. J Nutr. 1998 02; 128(2 Suppl):347S-350S.J Nutr1998-02-01T00:00:001998Roles of insulin and amino acids in the regulation of protein synthesis in the neonate.8110110Lee PD, Hwu K, Henson H, Brown BT, Bricker JT, LeBlanc AD, Fiorotto ML, Greenberg F, Klish WJBasic life sciencesBody composition studies in Prader-Willi syndrome: effects of growth hormone therapy. Basic Life Sci. 1993; 60:201-5.Basic Life Sci1993-01-01T00:00:001993Body composition studies in Prader-Willi syndrome: effects of growth hormone therapy.8493277Reeds PJ, Burrin DG, Davis TA, Fiorotto MLThe Proceedings of the Nutrition SocietyPostnatal growth of gut and muscle: competitors or collaborators. Proc Nutr Soc. 1993 Feb; 52(1):57-67.Proc Nutr Soc1993-02-01T00:00:001993Postnatal growth of gut and muscle: competitors or collaborators.10749771Fiorotto ML, Davis TA, Reeds PJAmerican journal of physiology. Regulatory, integrative and comparative physiologyRegulation of myofibrillar protein turnover during maturation in normal and undernourished rat pups. Am J Physiol Regul Integr Comp Physiol. 2000 Apr; 278(4):R845-54.Am J Physiol Regul Integr Comp Physiol2000-04-01T00:00:002000Regulation of myofibrillar protein turnover during maturation in normal and undernourished rat pups.Authorship 297805510828178Reeds PJ, Burrin DG, Davis TA, Fiorotto ML, Stoll B, van Goudoever JBThe Proceedings of the Nutrition SocietyProtein nutrition of the neonate. Proc Nutr Soc. 2000 Feb; 59(1):87-97.Proc Nutr Soc2000-02-01T00:00:002000Protein nutrition of the neonate.Authorship 300019626334346Manjar?n R, Columbus DA, Suryawan A, Nguyen HV, Hernandez-Garc?a AD, Hoang NM, Fiorotto ML, Davis TAmino acidsLeucine supplementation of a chronically restricted protein and energy diet enhances mTOR pathway activation but not muscle protein synthesis in neonatal pigs. Amino Acids. 2016 Jan; 48(1):257-267.Amino Acids2015-09-03T00:00:002015Leucine supplementation of a chronically restricted protein and energy diet enhances mTOR pathway activation but not muscle protein synthesis in neonatal pigs.26374843Columbus DA, Steinhoff-Wagner J, Suryawan A, Nguyen HV, Hernandez-Garcia A, Fiorotto ML, Davis TAAmerican journal of physiology. Endocrinology and metabolismImpact of prolonged leucine supplementation on protein synthesis and lean growth in neonatal pigs. Am J Physiol Endocrinol Metab. 2015 Sep 15; 309(6):E601-10.Am J Physiol Endocrinol Metab2015-08-04T00:00:002015Impact of prolonged leucine supplementation on protein synthesis and lean growth in neonatal pigs.9915875Burrin DG, Fiorotto ML, Hadsell DLThe Journal of nutritionTransgenic hypersecretion of des(1-3) human insulin-like growth factor I in mouse milk has limited effects on the gastrointestinal tract in suckling pups. J Nutr. 1999 Jan; 129(1):51-6.J Nutr1999-01-01T00:00:001999Transgenic hypersecretion of des(1-3) human insulin-like growth factor I in mouse milk has limited effects on the gastrointestinal tract in suckling pups.11287360Davis TA, Fiorotto ML, Beckett PR, Burrin DG, Reeds PJ, Wray-Cahen D, Nguyen HVAmerican journal of physiology. Endocrinology and metabolismDifferential effects of insulin on peripheral and visceral tissue protein synthesis in neonatal pigs. Am J Physiol Endocrinol Metab. 2001 May; 280(5):E770-9.Am J Physiol Endocrinol Metab2001-05-01T00:00:002001Differential effects of insulin on peripheral and visceral tissue protein synthesis in neonatal pigs.10585714Draghia-Akli R, Fiorotto ML, Hill LA, Malone PB, Deaver DR, Schwartz RJNature biotechnologyMyogenic expression of an injectable protease-resistant growth hormone-releasing hormone augments long-term growth in pigs. Nat Biotechnol. 1999 Dec; 17(12):1179-83.Nat Biotechnol1999-12-01T00:00:001999Myogenic expression of an injectable protease-resistant growth hormone-releasing hormone augments long-term growth in pigs.10682805Lorenzen CL, Koohmaraie M, Shackelford SD, Jahoor F, Freetly HC, Wheeler TL, Savell JW, Fiorotto MLJournal of animal scienceProtein kinetics in callipyge lambs. J Anim Sci. 2000 Jan; 78(1):78-87.J Anim Sci2000-01-01T00:00:002000Protein kinetics in callipyge lambs.9164987Dudley MA, Wykes L, Dudley AW, Fiorotto M, Burrin DG, Rosenberger J, Jahoor F, Reeds PJThe Journal of nutritionLactase phlorizin hydrolase synthesis is decreased in protein-malnourished pigs. J Nutr. 1997 May; 127(5):687-93.J Nutr1997-05-01T00:00:001997Lactase phlorizin hydrolase synthesis is decreased in protein-malnourished pigs.12217880Davis TA, Fiorotto ML, Burrin DG, Vann RC, Reeds PJ, Nguyen HV, Beckett PR, Bush JAAmerican journal of physiology. Endocrinology and metabolismAcute IGF-I infusion stimulates protein synthesis in skeletal muscle and other tissues of neonatal pigs. Am J Physiol Endocrinol Metab. 2002 Oct; 283(4):E638-47.Am J Physiol Endocrinol Metab2002-10-01T00:00:002002Acute IGF-I infusion stimulates protein synthesis in skeletal muscle and other tissues of neonatal pigs.12528713Fiorotto ML, Schwartz RJ, Delaughter MCFASEB journal : official publication of the Federation of American Societies for Experimental BiologyPersistent IGF-I overexpression in skeletal muscle transiently enhances DNA accretion and growth. FASEB J. 2003 Jan; 17(1):59-60.FASEB J2003-01-01T00:00:002003Persistent IGF-I overexpression in skeletal muscle transiently enhances DNA accretion and growth.12670834Khan AS, Fiorotto ML, Cummings KK, Pope MA, Brown PA, Draghia-Akli RAmerican journal of physiology. Endocrinology and metabolismMaternal GHRH plasmid administration changes pituitary cell lineage and improves progeny growth of pigs. Am J Physiol Endocrinol Metab. 2003 Jul; 285(1):E224-31.Am J Physiol Endocrinol Metab2003-04-01T00:00:002003Maternal GHRH plasmid administration changes pituitary cell lineage and improves progeny growth of pigs.9755078Wray-Cahen D, Nguyen HV, Burrin DG, Beckett PR, Fiorotto ML, Reeds PJ, Wester TJ, Davis TAThe American journal of physiologyResponse of skeletal muscle protein synthesis to insulin in suckling pigs decreases with development. Am J Physiol. 1998 10; 275(4):E602-9.Am J Physiol1998-10-01T00:00:001998Response of skeletal muscle protein synthesis to insulin in suckling pigs decreases with development.9950786Burrin DG, Wester TJ, Davis TA, Fiorotto ML, Chang XThe American journal of physiologyDexamethasone inhibits small intestinal growth via increased protein catabolism in neonatal pigs. Am J Physiol. 1999 02; 276(2):E269-77.Am J Physiol1999-02-01T00:00:001999Dexamethasone inhibits small intestinal growth via increased protein catabolism in neonatal pigs.10409133Davis TA, Fiorotto ML, Nguyen HV, Burrin DGThe American journal of physiologyAminoacyl-tRNA and tissue free amino acid pools are equilibrated after a flooding dose of phenylalanine. Am J Physiol. 1999 07; 277(1):E103-9.Am J Physiol1999-07-01T00:00:001999Aminoacyl-tRNA and tissue free amino acid pools are equilibrated after a flooding dose of phenylalanine.10632968Pond WG, Boleman SL, Fiorotto ML, Ho H, Knabe DA, Mersmann HJ, Savell JW, Su DRProceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)Perinatal ontogeny of brain growth in the domestic pig. Proc Soc Exp Biol Med. 2000 Jan; 223(1):102-8.Proc Soc Exp Biol Med2000-01-01T00:00:002000Perinatal ontogeny of brain growth in the domestic pig.26884386Boutry C, El-Kadi SW, Suryawan A, Steinhoff-Wagner J, Stoll B, Orellana RA, Nguyen HV, Kimball SR, Fiorotto ML, Davis TAAmerican journal of physiology. Endocrinology and metabolismPulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs. Am J Physiol Endocrinol Metab. 2016 04 15; 310(8):E699-E713.Am J Physiol Endocrinol Metab2016-02-16T00:00:002016Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs.11882508Davis TA, Fiorotto ML, Burrin DG, Reeds PJ, Nguyen HV, Beckett PR, Vann RC, O'Connor PMAmerican journal of physiology. Endocrinology and metabolismStimulation of protein synthesis by both insulin and amino acids is unique to skeletal muscle in neonatal pigs. Am J Physiol Endocrinol Metab. 2002 Apr; 282(4):E880-90.Am J Physiol Endocrinol Metab2002-04-01T00:00:002002Stimulation of protein synthesis by both insulin and amino acids is unique to skeletal muscle in neonatal pigs.10710502Vann RC, Nguyen HV, Reeds PJ, Burrin DG, Fiorotto ML, Steele NC, Deaver DR, Davis TAAmerican journal of physiology. Endocrinology and metabolismSomatotropin increases protein balance by lowering body protein degradation in fed, growing pigs. Am J Physiol Endocrinol Metab. 2000 Mar; 278(3):E477-83.Am J Physiol Endocrinol Metab2000-03-01T00:00:002000Somatotropin increases protein balance by lowering body protein degradation in fed, growing pigs.10962000Chakravarthy MV, Abraha TW, Schwartz RJ, Fiorotto ML, Booth FWThe Journal of biological chemistryInsulin-like growth factor-I extends in vitro replicative life span of skeletal muscle satellite cells by enhancing G1/S cell cycle progression via the activation of phosphatidylinositol 3'-kinase/Akt signaling pathway. J Biol Chem. 2000 Nov 17; 275(46):35942-52.J Biol Chem2000-11-17T00:00:002000Insulin-like growth factor-I extends in vitro replicative life span of skeletal muscle satellite cells by enhancing G1/S cell cycle progression via the activation of phosphatidylinositol 3'-kinase/Akt signaling pathway.74Professor54Instructor14Associate Professor46Distinguished Emeritus Professor3Adjunct Associate Professor1512632Patterson BW, Wong WW, Sheng HP, Mersmann HJ, Insull W, Klein PD, Fiorotto ML, Pond WGThe Journal of nutritionNeonatal genetically lean and obese pigs respond differently to dietary cholesterol. J Nutr. 1992 Sep; 122(9):1830-9.J Nutr1992-09-01T00:00:001992Neonatal genetically lean and obese pigs respond differently to dietary cholesterol.Authorship 3167187Authorship 3167196Authorship 3167208Authorship 3167214Authorship 31672227328325Meng X, Wang W, Lu H, He LJ, Chen W, Chao ES, Fiorotto ML, Tang B, Herrera JA, Seymour ML, Neul JL, Pereira FA, Tang J, Xue M, Zoghbi HYeLifeManipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders. Elife. 2016 06 21; 5.Elife2016-06-21T00:00:002016Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders.27033262Eclarinal JD, Zhu S, Baker MS, Piyarathna DB, Coarfa C, Fiorotto ML, Waterland RAFASEB journal : official publication of the Federation of American Societies for Experimental BiologyMaternal exercise during pregnancy promotes physical activity in adult offspring. FASEB J. 2016 07; 30(7):2541-8.FASEB J2016-03-31T00:00:002016Maternal exercise during pregnancy promotes physical activity in adult offspring.Kao M, Columbus DA, Suryawan A, Steinhoff-Wagner J, Hernandez-Garcia A, Nguyen HV, Fiorotto ML, Davis TA.Am J Physiol Endocrinol Metab.Enteral β-hydroxy-β-methylbutyrate supplementation increases protein synthesis in skeletal muscle of neonatal pigs. Am J Physiol Endocrinol Metab. 2016; 310(11):E1072-84.2016-06-01T00:00:002016Enteral β-hydroxy-β-methylbutyrate supplementation increases protein synthesis in skeletal muscle of neonatal pigs11438121Chakravarthy MV, Fiorotto ML, Schwartz RJ, Booth FWMechanisms of ageing and developmentLong-term insulin-like growth factor-I expression in skeletal muscles attenuates the enhanced in vitro proliferation ability of the resident satellite cells in transgenic mice. Mech Ageing Dev. 2001 Sep; 122(12):1303-20.Mech Ageing Dev2001-09-01T00:00:002001Long-term insulin-like growth factor-I expression in skeletal muscles attenuates the enhanced in vitro proliferation ability of the resident satellite cells in transgenic mice.16478773Orellana RA, O'Connor PM, Bush JA, Suryawan A, Thivierge MC, Nguyen HV, Fiorotto ML, Davis TAAmerican journal of physiology. Endocrinology and metabolismModulation of muscle protein synthesis by insulin is maintained during neonatal endotoxemia. Am J Physiol Endocrinol Metab. 2006 Jul; 291(1):E159-66.Am J Physiol Endocrinol Metab2006-02-14T00:00:002006Modulation of muscle protein synthesis by insulin is maintained during neonatal endotoxemia.12514110Draghia-Akli R, Ellis KM, Hill LA, Malone PB, Fiorotto MLFASEB journal : official publication of the Federation of American Societies for Experimental BiologyHigh-efficiency growth hormone-releasing hormone plasmid vector administration into skeletal muscle mediated by electroporation in pigs. FASEB J. 2003 Mar; 17(3):526-8.FASEB J2003-01-02T00:00:002003High-efficiency growth hormone-releasing hormone plasmid vector administration into skeletal muscle mediated by electroporation in pigs.2051230Burrin DG, Davis TA, Fiorotto ML, Reeds PJThe Journal of nutritionStage of development and fasting affect protein synthetic activity in the gastrointestinal tissues of suckling rats. J Nutr. 1991 Jul; 121(7):1099-108.J Nutr1991-07-01T00:00:001991Stage of development and fasting affect protein synthetic activity in the gastrointestinal tissues of suckling rats.2072830Hergenroeder AC, Fiorotto ML, Klish WJMedicine and science in sports and exerciseBody composition in ballet dancers measured by total body electrical conductivity. Med Sci Sports Exerc. 1991 May; 23(5):528-33.Med Sci Sports Exerc1991-05-01T00:00:001991Body composition in ballet dancers measured by total body electrical conductivity.19692527Wilson FA, Suryawan A, Orellana RA, Kimball SR, Gazzaneo MC, Nguyen HV, Fiorotto ML, Davis TAThe Journal of nutritionFeeding rapidly stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing translation initiation. J Nutr. 2009 Oct; 139(10):1873-80.J Nutr2009-08-19T00:00:002009Feeding rapidly stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing translation initiation.15030312Hornberger TA, Stuppard R, Conley KE, Fedele MJ, Fiorotto ML, Chin ER, Esser KAThe Biochemical journalMechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism. Biochem J. 2004 Jun 15; 380(Pt 3):795-804.Biochem J2004-06-15T00:00:002004Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism.19809401Khan AS, Draghia-Akli R, Shypailo RJ, Ellis KI, Mersmann H, Fiorotto MLMolecular therapy : the journal of the American Society of Gene TherapyA comparison of the growth responses following intramuscular GHRH plasmid administration versus daily growth hormone injections in young pigs. Mol Ther. 2010 Feb; 18(2):327-33.Mol Ther2009-10-06T00:00:002009A comparison of the growth responses following intramuscular GHRH plasmid administration versus daily growth hormone injections in young pigs.16079306Hadsell DL, Torres DT, Lawrence NA, George J, Parlow AF, Lee AV, Fiorotto MLBiology of reproductionOverexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation. Biol Reprod. 2005 Dec; 73(6):1116-25.Biol Reprod2005-08-03T00:00:002005Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation.15471807Draghia-Akli R, Fiorotto MLJournal of animal scienceA new plasmid-mediated approach to supplement somatotropin production in pigs. J Anim Sci. 2004; 82 E-Suppl:E264-269.J Anim Sci2004-01-01T00:00:002004A new plasmid-mediated approach to supplement somatotropin production in pigs.2480066Davis TA, Fiorotto ML, Nguyen HV, Reeds PJThe American journal of physiologyProtein turnover in skeletal muscle of suckling rats. Am J Physiol. 1989 Nov; 257(5 Pt 2):R1141-6.Am J Physiol1989-11-01T00:00:001989Protein turnover in skeletal muscle of suckling rats.22391631Suryawan A, Torrazza RM, Gazzaneo MC, Orellana RA, Fiorotto ML, El-Kadi SW, Srivastava N, Nguyen HV, Davis TAPediatric researchEnteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways. Pediatr Res. 2012 Apr; 71(4 Pt 1):324-31.Pediatr Res2012-02-15T00:00:002012Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways.16166219Oliver WT, Rosenberger J, Lopez R, Gomez A, Cummings KK, Fiorotto MLEndocrinologyThe local expression and abundance of insulin-like growth factor (IGF) binding proteins in skeletal muscle are regulated by age and gender but not local IGF-I in vivo. Endocrinology. 2005 Dec; 146(12):5455-62.Endocrinology2005-09-15T00:00:002005The local expression and abundance of insulin-like growth factor (IGF) binding proteins in skeletal muscle are regulated by age and gender but not local IGF-I in vivo.16442254Hadsell DL, Torres D, George J, Capuco AV, Ellis SE, Fiorotto MLExperimental gerontologyChanges in secretory cell turnover, and mitochondrial oxidative damage in the mouse mammary gland during a single prolonged lactation cycle suggest the possibility of accelerated cellular aging. Exp Gerontol. 2006 Mar; 41(3):271-81.Exp Gerontol2006-01-25T00:00:002006Changes in secretory cell turnover, and mitochondrial oxidative damage in the mouse mammary gland during a single prolonged lactation cycle suggest the possibility of accelerated cellular aging.1934858Fiorotto ML, Klish WJClinics in perinatologyTotal body electrical conductivity measurements in the neonate. Clin Perinatol. 1991 Sep; 18(3):611-27.Clin Perinatol1991-09-01T00:00:001991Total body electrical conductivity measurements in the neonate.2072831Hergenroeder AC, Wong WW, Fiorotto ML, Smith EO, Klish WJMedicine and science in sports and exerciseTotal body water and fat-free mass in ballet dancers: comparing isotope dilution and TOBEC. Med Sci Sports Exerc. 1991 May; 23(5):534-41.Med Sci Sports Exerc1991-05-01T00:00:001991Total body water and fat-free mass in ballet dancers: comparing isotope dilution and TOBEC.2058738Fiorotto ML, Burrin DG, Perez M, Reeds PJThe American journal of physiologyIntake and use of milk nutrients by rat pups suckled in small, medium, or large litters. Am J Physiol. 1991 Jun; 260(6 Pt 2):R1104-13.Am J Physiol1991-06-01T00:00:001991Intake and use of milk nutrients by rat pups suckled in small, medium, or large litters.19057192Davis TA, Fiorotto MLCurrent opinion in clinical nutrition and metabolic careRegulation of muscle growth in neonates. Curr Opin Clin Nutr Metab Care. 2009 Jan; 12(1):78-85.Curr Opin Clin Nutr Metab Care2009-01-01T00:00:002009Regulation of muscle growth in neonates.Authorship 6536914Authorship 654629528096434Gokulakrishnan G, Chang X, Fleischmann R, Fiorotto MLThe Journal of endocrinologyPrecocious glucocorticoid exposure reduces skeletal muscle satellite cells in the fetal rat. J Endocrinol. 2017 03; 232(3):561-572.J Endocrinol2017-01-17T00:00:002017Precocious glucocorticoid exposure reduces skeletal muscle satellite cells in the fetal rat.28099477Crossland RF, Balasa A, Ramakrishnan R, Mahadevan SK, Fiorotto ML, Van den Veyver IBPloS oneChronic Maternal Low-Protein Diet in Mice Affects Anxiety, Night-Time Energy Expenditure and Sleep Patterns, but Not Circadian Rhythm in Male Offspring. PLoS One. 2017; 12(1):e0170127.PLoS One2017-01-18T00:00:002017Chronic Maternal Low-Protein Diet in Mice Affects Anxiety, Night-Time Energy Expenditure and Sleep Patterns, but Not Circadian Rhythm in Male Offspring.21042574Flynn JM, Meadows E, Fiorotto M, Klein WHPloS oneMyogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse. PLoS One. 2010 Oct 22; 5(10):e13535.PLoS One2010-10-22T00:00:002010Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse.21189371Hadsell DL, Olea W, Wei J, Fiorotto ML, Matsunami RK, Engler DA, Collier RJPhysiological genomicsDevelopmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle. Physiol Genomics. 2011 Mar 29; 43(6):271-85.Physiol Genomics2010-12-28T00:00:002010Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle.21654549Gazzaneo MC, Orellana RA, Suryawan A, Tuckow AP, Kimball SR, Wilson FA, Nguyen HV, Torrazza RM, Fiorotto ML, Davis TAPediatric researchDifferential regulation of protein synthesis and mTOR signaling in skeletal muscle and visceral tissues of neonatal pigs after a meal. Pediatr Res. 2011 Sep; 70(3):253-60.Pediatr Res2011-09-01T00:00:002011Differential regulation of protein synthesis and mTOR signaling in skeletal muscle and visceral tissues of neonatal pigs after a meal.20935141Suryawan A, Orellana RA, Fiorotto ML, Davis TAJournal of animal scienceTriennial Growth Symposium: leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigs. J Anim Sci. 2011 Jul; 89(7):2004-16.J Anim Sci2010-10-08T00:00:002010Triennial Growth Symposium: leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigs.22013202Balasa A, Sanchez-Valle A, Sadikovic B, Sangi-Haghpeykar H, Bravo J, Chen L, Liu W, Wen S, Fiorotto ML, Veyver IBThe Journal of nutritionChronic maternal protein deprivation in mice is associated with overexpression of the cohesin-mediator complex in liver of their offspring. J Nutr. 2011 Dec; 141(12):2106-12.J Nutr2011-10-19T00:00:002011Chronic maternal protein deprivation in mice is associated with overexpression of the cohesin-mediator complex in liver of their offspring.22130841Fiorotto ML, Sosa HA, Davis TAMethods in molecular biology (Clifton, N.J.)In vivo measurement of muscle protein synthesis rate using the flooding dose technique. Methods Mol Biol. 2012; 798:245-64.Methods Mol Biol2012-01-01T00:00:002012In vivo measurement of muscle protein synthesis rate using the flooding dose technique.22277935Orellana RA, Suryawan A, Wilson FA, Gazzaneo MC, Fiorotto ML, Nguyen HV, Davis TAAmerican journal of physiology. Regulatory, integrative and comparative physiologyDevelopment aggravates the severity of skeletal muscle catabolism induced by endotoxemia in neonatal pigs. Am J Physiol Regul Integr Comp Physiol. 2012 Mar 15; 302(6):R682-90.Am J Physiol Regul Integr Comp Physiol2012-01-25T00:00:002012Development aggravates the severity of skeletal muscle catabolism induced by endotoxemia in neonatal pigs.Authorship 785604128190934Fiorotto MThe biochemistThe making of a muscle. Biochem (Lond). 2012 Jun; 34(3):4-11.Biochem (Lond)2012-06-01T00:00:002012The making of a muscle.22094293Radley-Crabb HG, Fiorotto ML, Grounds MDPLoS currentsThe different impact of a high fat diet on dystrophic mdx and control C57Bl/10 mice. PLoS Curr. 2011 Nov 15; 3:RRN1276.PLoS Curr2011-11-15T00:00:002011The different impact of a high fat diet on dystrophic mdx and control C57Bl/10 mice.Authorship 10171513654439Sadre M, Sheng HP, Fiorotto M, Nichols BLJournal of applied physiology (Bethesda, Md. : 1985)Electrolyte composition changes of chronically K-depleted rats after K loading. J Appl Physiol (1985). 1987 Aug; 63(2):765-9.J Appl Physiol (1985)1987-08-01T00:00:001987Electrolyte composition changes of chronically K-depleted rats after K loading.7578625Butte NF, Wong WW, Fiorotto M, Smith EO, Garza CBiology of the neonateInfluence of early feeding mode on body composition of infants. Biol Neonate. 1995; 67(6):414-24.Biol Neonate1995-01-01T00:00:001995Influence of early feeding mode on body composition of infants.7719959Fiorotto ML, Davis TA, Schoknecht P, Mersmann HJ, Pond WGObesity researchBoth maternal over- and undernutrition during gestation increase the adiposity of young adult progeny in rats. Obes Res. 1995 Mar; 3(2):131-41.Obes Res1995-03-01T00:00:001995Both maternal over- and undernutrition during gestation increase the adiposity of young adult progeny in rats.8027865Davis TA, Nguyen HV, Garcia-Bravo R, Fiorotto ML, Jackson EM, Lewis DS, Lee DR, Reeds PJThe Journal of nutritionAmino acid composition of human milk is not unique. J Nutr. 1994 Jul; 124(7):1126-32.J Nutr1994-07-01T00:00:001994Amino acid composition of human milk is not unique.8929857Beckett PR, Fiorotto ML, Davis TA, Reeds PJPediatric researchCorticosterone has independent effects on tissue maturation and growth in the suckling rat. Pediatr Res. 1996 Mar; 39(3):395-400.Pediatr Res1996-03-01T00:00:001996Corticosterone has independent effects on tissue maturation and growth in the suckling rat.9202081Burrin DG, Davis TA, Ebner S, Schoknecht PA, Fiorotto ML, Reeds PJThe Journal of nutritionColostrum enhances the nutritional stimulation of vital organ protein synthesis in neonatal pigs. J Nutr. 1997 Jul; 127(7):1284-9.J Nutr1997-07-01T00:00:001997Colostrum enhances the nutritional stimulation of vital organ protein synthesis in neonatal pigs.Authorship 870036628533420Hennebry A, Oldham J, Shavlakadze T, Grounds MD, Sheard P, Fiorotto ML, Falconer S, Smith HK, Berry C, Jeanplong F, Bracegirdle J, Matthews K, Nicholas G, Senna-Salerno M, Watson T, McMahon CDThe Journal of endocrinologyIGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice. J Endocrinol. 2017 Aug; 234(2):187-200.J Endocrinol2017-05-22T00:00:002017IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice.9458744Wester TJ, Davis TA, Fiorotto ML, Burrin DGThe American journal of physiologyExogenous growth hormone stimulates somatotropic axis function and growth in neonatal pigs. Am J Physiol. 1998 01; 274(1):E29-37.Am J Physiol1998-01-01T00:00:001998Exogenous growth hormone stimulates somatotropic axis function and growth in neonatal pigs.9725801Criswell DS, Booth FW, DeMayo F, Schwartz RJ, Gordon SE, Fiorotto MLThe American journal of physiologyOverexpression of IGF-I in skeletal muscle of transgenic mice does not prevent unloading-induced atrophy. Am J Physiol. 1998 Sep; 275(3 Pt 1):E373-9.Am J Physiol1998-09-01T00:00:001998Overexpression of IGF-I in skeletal muscle of transgenic mice does not prevent unloading-induced atrophy.1373233Burrin DG, Davis TA, Fiorotto ML, Reeds PJPediatric researchHepatic protein synthesis in suckling rats: effects of stage of development and fasting. Pediatr Res. 1992 Mar; 31(3):247-52.Pediatr Res1992-03-01T00:00:001992Hepatic protein synthesis in suckling rats: effects of stage of development and fasting.9928604Wester TJ, Fiorotto ML, Klindt J, Burrin DGJournal of animal scienceFeeding colostrum increases circulating insulin-like growth factor I in newborn pigs independent of endogenous growth hormone secretion. J Anim Sci. 1998 Dec; 76(12):3003-9.J Anim Sci1998-12-01T00:00:001998Feeding colostrum increases circulating insulin-like growth factor I in newborn pigs independent of endogenous growth hormone secretion.10544175Delaughter MC, Taffet GE, Fiorotto ML, Entman ML, Schwartz RJFASEB journal : official publication of the Federation of American Societies for Experimental BiologyLocal insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice. FASEB J. 1999 Nov; 13(14):1923-9.FASEB J1999-11-01T00:00:001999Local insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice.11004243Fiorotto ML, Davis TA, Reeds PJ, Burrin DGPediatric researchNonnutritive factors in colostrum enhance myofibrillar protein synthesis in the newborn Pig. Pediatr Res. 2000 Oct; 48(4):511-7.Pediatr Res2000-10-01T00:00:002000Nonnutritive factors in colostrum enhance myofibrillar protein synthesis in the newborn Pig.12514258Davis TA, Burrin DG, Fiorotto MLThe Journal of nutritionPeter J. Reeds (February 22, 1945-August 13, 2002). J Nutr. 2003 Jan; 133(1):5-8.J Nutr2003-01-01T00:00:002003Peter J. Reeds (February 22, 1945-August 13, 2002).Authorship 8757992Authorship 875847Authorship 875848379878Coward WA, Fiorotto MThe Proceedings of the Nutrition SocietyThe pathogenesis of oedema in kwashiorkor--the role of plasma proteins. Proc Nutr Soc. 1979 May 01; 38(1):51-9.Proc Nutr Soc1979-05-01T00:00:001979The pathogenesis of oedema in kwashiorkor--the role of plasma proteins.Pond WG, Schoknecht PA, Fiorotto ML, Walton L, Tran V, et al.Nutrition Research (New York, N.Y.)Differential nutrient partitioning in pregnant dams fed restricted amounts of a balanced diet versus restricted nonprotein calories. Nutrition Research (New York, N.Y.). 1994; 14(7):1067-1076.1994-07-01T00:00:001994Differential nutrient partitioning in pregnant dams fed restricted amounts of a balanced diet versus restricted nonprotein caloriesSchoknecht PA, Pond WG, Ellis KJ, Shypailo R, Fiorotto ML, et al.Nutrition Research (New York, N.Y.)Morphology and cellularity of brain and visceral organs of severely undernourished baby pigs are restored after eight weeks of refeeding. Nutrition Research (New York, N.Y.). 1994; 14(6):841-849.1994-06-01T00:00:001994Morphology and cellularity of brain and visceral organs of severely undernourished baby pigs are restored after eight weeks of refeedingAuthorship 875850Authorship 875851Authorship 875852Authorship 875853Authorship 875854Authorship 875855Cochran WJ, Wong WW, Fiorotto ML, Sheng H, Klein PD, et alThe use of total body electrical conductivity (TOBEC) to determine total body waterIn Vivo Body Composition Studies. Ellis KJ, Yasumura S, Morgan WD, editors. The use of total body electrical conductivity (TOBEC) to determine total body water. 1987; 175-179.1987-01-01T00:00:001987In Vivo Body Composition Studies. Ellis KJ, Yasumura S, Morgan WD, editorsFiorotto ML, Cochran WJ, Sheng H, Klish WJTotal body electrical conductivity (TOBEC) measurements for the determination of body composition in the human infantIn Vivo Body Composition Studies. Ellis KJ, Yasumura S, Morgan WD, editors. Total body electrical conductivity (TOBEC) measurements for the determination of body composition in the human infant. 1987; 179-186.1987-01-01T00:00:001987In Vivo Body Composition Studies. Ellis KJ, Yasumura S, Morgan WD, editorsFiorotto MLThe application of TOBEC (total body electrical conductivity) measurements for estimating the fat and fat-free mass of human infantsProceedings of the 98th Ross conference on pediatric research on body composition measurements in infants and children. Klish WJ, Kretchmer N, editors. The application of TOBEC (total body electrical conductivity) measurements for estimating the fat and fat-free mass of human infants. 1989; 57-66.1989-01-01T00:00:001989Proceedings of the 98th Ross conference on pediatric research on body composition measurements in infants and children. Klish WJ, Kretchmer N, editorsFiorotto ML, Burrin DG, Reeds PJEfficiency of energy utilization by suckling rats at different ages on different planes of nutritionProceedings of the 12th Symposium on Energy Metabolism of Farm Animals. Efficiency of energy utilization by suckling rats at different ages on different planes of nutrition. 1991; 146-149.1991-01-01T00:00:001991Proceedings of the 12th Symposium on Energy Metabolism of Farm AnimalsFiorotto MLQuantitation of fat-free and fat mass in infants using total body electrical conductivity measurementsFetal and Neonatal Physiological Measurements. Lafeber HN, editor. Quantitation of fat-free and fat mass in infants using total body electrical conductivity measurements. 1991; 311-318.1991-01-01T00:00:001991Fetal and Neonatal Physiological Measurements. Lafeber HN, editorReeds PJ, Fiorotto ML, Davis TA, Burrin DGHomeorrhesis and homeostasis: problems of growth and maintenanceFrontiers and New Horizons in Amino Acid Research. Takai K, editor. Homeorrhesis and homeostasis: problems of growth and maintenance. 1992; 133-144.1992-01-01T00:00:001992Frontiers and New Horizons in Amino Acid Research. Takai K, editorAuthorship 875968Authorship 875969Authorship 875970Authorship 875971Authorship 875972Authorship 875973Authorship 875974Lee PD, Hwu K, Henson H, Brown BT, Bricker JT, LeBlanc AD, Fiorotto ML, Greenberg F, Klish WJBody composition studies in Prader-Willi syndrome: effects of growth hormone therapyHuman Body Composition: in vivo methods, models, and assessment. Ellis KJ, Eastman JD, editors. Body composition studies in Prader-Willi syndrome: effects of growth hormone therapy. 1993; 201-205.1993-01-01T00:00:001993Human Body Composition: in vivo methods, models, and assessment. Ellis KJ, Eastman JD, editorsBurrin DG, Fiorotto ML, Davis TAImportance of neonatal nutrition: what have we learned from human and animal studies?Proceedings of 63rd Cornell Nutrition Conference. Importance of neonatal nutrition: what have we learned from human and animal studies?. 2010; 1-13.2010-01-01T00:00:002010Proceedings of 63rd Cornell Nutrition ConferenceDavis TA, Suryawan A, Fiorotto ML, Orellana RA, Burrin DGDevelopmental changes in insulin- and amino acid-induced mTOR signaling regulate muscle protein synthesis in neonatal pigsEnergy and Protein Metabolism and Nutrition. Crovetto GM, editor. Developmental changes in insulin- and amino acid-induced mTOR signaling regulate muscle protein synthesis in neonatal pigs. 2010; 249-250.2010-01-01T00:00:002010Energy and Protein Metabolism and Nutrition. Crovetto GM, editorFiorotto ML, Butte NFEvaluation of protein nutritional statusSpecific Protein Analysis. Miller LP, editor. Evaluation of protein nutritional status. 1983; 1-13.1983-01-01T00:00:001983Specific Protein Analysis. Miller LP, editorFiorotto MLMeasurements of total body electrical conductivity (TOBEC) for the estimation of fat and fat-free massNew Techniques in Nutritional Research. Whitehead RG, editor. Measurements of total body electrical conductivity (TOBEC) for the estimation of fat and fat-free mass. 1991; 281-301.1991-01-01T00:00:001991New Techniques in Nutritional Research. Whitehead RG, editorReeds PJ, Fiorotto ML, Davis TANutrient partitioning - an overviewThe Science of Food Regulation. Bray GA, Ryan DH, editors. Nutrient partitioning - an overview. 1992; 103-120.1992-01-01T00:00:001992The Science of Food Regulation. Bray GA, Ryan DH, editorsReeds PJ, Fiorotto ML, Heird WCOpportunities for the manipulation of nutrition and growthThe Contribution of Nutrition to Human and Animal Health. Widdowson EM, Mathers JC, editors. Opportunities for the manipulation of nutrition and growth. 1992; 242-253.1992-01-01T00:00:001992The Contribution of Nutrition to Human and Animal Health. Widdowson EM, Mathers JC, editorsAuthorship 876329Authorship 876330Authorship 876331Authorship 876332Authorship 876333Authorship 876334Authorship 876335Authorship 876340Authorship 876341Authorship 876342Reeds PJ, Burrin DG, Davis TA, Fiorotto ML, Mersmann HJGrowth regulation with particular reference to the pigGrowth of the Pig. Hollis GR, editor. Growth regulation with particular reference to the pig. 1993; 1-32.1993-01-01T00:00:001993Growth of the Pig. Hollis GR, editorReeds PJ, Fiorotto MLGrowth: An overview of human growth and developmentEncyclopedia of Food Science, Food Technology and Nutrition. Macrae R, Robinson RK, Sadler MJ, editors. Growth: An overview of human growth and development. 1993; 2568-2572.1993-01-01T00:00:001993Encyclopedia of Food Science, Food Technology and Nutrition. Macrae R, Robinson RK, Sadler MJ, editorsReeds PJ, Burrin DB, Davis TA, Stoll B, Wykes LJ, et alThe piglet as a model for the study of growth, development, and nutritionManipulating Pig Production. Cranwell P, editor. The piglet as a model for the study of growth, development, and nutrition. 1997; 1-33.1997-01-01T00:00:001997Manipulating Pig Production. Cranwell P, editorFiorotto MLGrowth and Development: Physiological AspectsEncyclopedia of Human Nutrition. Sadler M, Caballero B, Strain E, editors. Growth and Development: Physiological Aspects. 1998; 983-994.1998-01-01T00:00:001998Encyclopedia of Human Nutrition. Sadler M, Caballero B, Strain E, editorsDavis TA, Fiorotto MLRegulation of skeletal muscle protein metabolism in growing animalsBiology of Metabolism of Growing Animals. Burrin DG, Mersmann HJ, editors. Regulation of skeletal muscle protein metabolism in growing animals. 2005; 37-68.2005-01-01T00:00:002005Biology of Metabolism of Growing Animals. Burrin DG, Mersmann HJ, editorsDavis TA, Fiorotto ML, Burrin DG, Vann RCProtein synthesis in organs and tissue: quantitative methods in laboratory animalsMethods for Investigation of Amino Acid and Protein Metabolism. El-Khoury AE, editor. Protein synthesis in organs and tissue: quantitative methods in laboratory animals. 1999; 37-68.1999-01-01T00:00:001999Methods for Investigation of Amino Acid and Protein Metabolism. El-Khoury AE, editorFiorotto MLProteinsPediatric Nutrition Handbook. 7th ed. Kleinman RE, editor. Proteins. 2014.2014-01-01T00:00:002014Pediatric Nutrition Handbook. 7th ed. Kleinman RE, editorFiorotto MLProteinsPediatric Nutrition Handbook. 5th ed. Kleinman RE, editor. Proteins. 2004.2004-01-01T00:00:002004Pediatric Nutrition Handbook. 5th ed. Kleinman RE, editorFiorotto MLProteinsPediatric Nutrition Handbook. 6th ed. Kleinman RE, editor. Proteins. 2009.2009-01-01T00:00:002009Pediatric Nutrition Handbook. 6th ed. Kleinman RE, editorFiorotto MLProteinsPediatric Nutrition Handbook. 4th ed. Kleinman RE, editor. Proteins. 1998.1998-01-01T00:00:001998Pediatric Nutrition Handbook. 4th ed. Kleinman RE, editor14710342Lee AV, Taylor ST, Greenall J, Mills JD, Tonge DW, Zhang P, George J, Fiorotto ML, Hadsell DLHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolismeRapid induction of IGF-IR signaling in normal and tumor tissue following intravenous injection of IGF-I in mice. Horm Metab Res. 2003 Nov-Dec; 35(11-12):651-5.Horm Metab Res2003-11-01T00:00:002003Rapid induction of IGF-IR signaling in normal and tumor tissue following intravenous injection of IGF-I in mice.1721504Davis TA, Fiorotto ML, Nguyen HV, Burrin DG, Reeds PJThe American journal of physiologyResponse of muscle protein synthesis to fasting in suckling and weaned rats. Am J Physiol. 1991 Dec; 261(6 Pt 2):R1373-80.Am J Physiol1991-12-01T00:00:001991Response of muscle protein synthesis to fasting in suckling and weaned rats.16907640Fiorotto ML, Lopez R, Oliver WT, Khan AS, Draghia-Akli RDNA and cell biologyTransplacental transfer of a growth hormone-releasing hormone peptide from mother to fetus in the rat. DNA Cell Biol. 2006 Aug; 25(8):429-37.DNA Cell Biol2006-08-01T00:00:002006Transplacental transfer of a growth hormone-releasing hormone peptide from mother to fetus in the rat.17785597Davis TA, Suryawan A, Orellana RA, Nguyen HV, Fiorotto MLJournal of animal sciencePostnatal ontogeny of skeletal muscle protein synthesis in pigs. J Anim Sci. 2008 Apr; 86(14 Suppl):E13-8.J Anim Sci2007-09-04T00:00:002007Postnatal ontogeny of skeletal muscle protein synthesis in pigs.Authorship 1041347Authorship 10541552080173Reeds PJ, Fiorotto MLThe Proceedings of the Nutrition SocietyGrowth in perspective. Proc Nutr Soc. 1990 Oct; 49(3):411-20.Proc Nutr Soc1990-10-01T00:00:001990Growth in perspective.20188245Khan AS, Bodles-Brakhop AM, Fiorotto ML, Draghia-Akli RVaccineEffects of maternal plasmid GHRH treatment on offspring growth. Vaccine. 2010 Feb 23; 28(8):1905-10.Vaccine2010-02-23T00:00:002010Effects of maternal plasmid GHRH treatment on offspring growth.Authorship 105995320962152Murgas Torrazza R, Suryawan A, Gazzaneo MC, Orellana RA, Frank JW, Nguyen HV, Fiorotto ML, El-Kadi S, Davis TAThe Journal of nutritionLeucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation. J Nutr. 2010 Dec; 140(12):2145-52.J Nutr2010-10-20T00:00:002010Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation.21298106Ma X, Lin L, Qin G, Lu X, Fiorotto M, Dixit VD, Sun YPloS oneAblations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging. PLoS One. 2011 Jan 26; 6(1):e16391.PLoS One2011-01-26T00:00:002011Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging.2421133Fiorotto ML, Shulman RJ, Sheng HP, Garza CMetabolism: clinical and experimentalThe effects of different total parenteral nutrition fuel mixes on skeletal muscle composition of infant miniature pigs. Metabolism. 1986 Apr; 35(4):354-9.Metabolism1986-04-01T00:00:001986The effects of different total parenteral nutrition fuel mixes on skeletal muscle composition of infant miniature pigs.22013195Gazzaneo MC, Suryawan A, Orellana RA, Torrazza RM, El-Kadi SW, Wilson FA, Kimball SR, Srivastava N, Nguyen HV, Fiorotto ML, Davis TAThe Journal of nutritionIntermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs. J Nutr. 2011 Dec; 141(12):2152-8.J Nutr2011-10-19T00:00:002011Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs.22422665Gokulakrishnan G, Estrada IJ, Sosa HA, Fiorotto MLAmerican journal of physiology. Regulatory, integrative and comparative physiologyIn utero glucocorticoid exposure reduces fetal skeletal muscle mass in rats independent of effects on maternal nutrition. Am J Physiol Regul Integr Comp Physiol. 2012 May 15; 302(10):R1143-52.Am J Physiol Regul Integr Comp Physiol2012-03-14T00:00:002012In utero glucocorticoid exposure reduces fetal skeletal muscle mass in rats independent of effects on maternal nutrition.Authorship 884215729728917Manjar?n R, Columbus DA, Solis J, Hernandez-Garc?a AD, Suryawan A, Nguyen HV, McGuckin MM, Jimenez RT, Fiorotto ML, Davis TAAmino acidsShort- and long-term effects of leucine and branched-chain amino acid supplementation of a protein- and energy-reduced diet on muscle protein metabolism in neonatal pigs. Amino Acids. 2018 07; 50(7):943-959.Amino Acids2018-05-04T00:00:002018Short- and long-term effects of leucine and branched-chain amino acid supplementation of a protein- and energy-reduced diet on muscle protein metabolism in neonatal pigs.true1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Adjunct Associate ProfessorAdjunct Associate Professortrue1ProfessorProfessortrue1InstructorInstructortrue1InstructorInstructor29786674May T, Klatt KC, Smith J, Castro E, Manary M, Caudill MA, Jahoor F, Fiorotto MLNutrientsCholine Supplementation Prevents a Hallmark Disturbance of Kwashiorkor in Weanling Mice Fed a Maize Vegetable Diet: Hepatic Steatosis of Undernutrition. Nutrients. 2018 May 22; 10(5).Nutrients2018-05-22T00:00:002018Choline Supplementation Prevents a Hallmark Disturbance of Kwashiorkor in Weanling Mice Fed a Maize Vegetable Diet: Hepatic Steatosis of Undernutrition.D009124Chemicals & Drugs2135650.721838Muscle ProteinsAuthorship 1030632D014176Physiology3288910.72502Protein BiosynthesisD007930Chemicals & Drugs1053520.854555LeucineD013552Living Beings41415390.715352SwineAuthorship 9166663Authorship 9167451Authorship 9246678Authorship 9254283Authorship 9340872Authorship 9345628Authorship 939265529910096Verhaart IEC, van den Engel-Hoek L, Fiorotto ML, Franken-Verbeek M, Vroom E, workshop participantsNeuromuscular disorders : NMDNutrition in Duchenne muscular dystrophy 16-18 March 2018, Zaandam, the Netherlands. Neuromuscul Disord. 2018 08; 28(8):680-689.Neuromuscul Disord2018-05-16T00:00:002018Nutrition in Duchenne muscular dystrophy 16-18 March 2018, Zaandam, the Netherlands.29991029Fiorotto ML, Davis TANestle Nutrition Institute workshop seriesCritical Windows for the Programming Effects of Early-Life Nutrition on Skeletal Muscle Mass. Nestle Nutr Inst Workshop Ser. 2018; 89:25-35.Nestle Nutr Inst Workshop Ser2018-07-10T00:00:002018Critical Windows for the Programming Effects of Early-Life Nutrition on Skeletal Muscle Mass.29972780Singh RK, Kolonin AM, Fiorotto ML, Cooper TACell reportsRbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis. Cell Rep. 2018 07 03; 24(1):197-208.Cell Rep2018-07-03T00:00:002018Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis.30239549El-Kadi SW, Boutry C, Suryawan A, Gazzaneo MC, Orellana RA, Srivastava N, Nguyen HV, Kimball SR, Fiorotto ML, Davis TAThe American journal of clinical nutritionIntermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet model. Am J Clin Nutr. 2018 10 01; 108(4):830-841.Am J Clin Nutr2018-10-01T00:00:002018Intermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet model.30016362Crossland RF, Balasa A, Ramakrishnan R, Mahadevan SK, Fiorotto ML, Van den Veyver IBPloS oneCorrection: Chronic Maternal Low-Protein Diet in Mice Affects Anxiety, Night-Time Energy Expenditure and Sleep Patterns, but Not Circadian Rhythm in Male Offspring. PLoS One. 2018; 13(7):e0201079.PLoS One2018-07-17T00:00:002018Correction: Chronic Maternal Low-Protein Diet in Mice Affects Anxiety, Night-Time Energy Expenditure and Sleep Patterns, but Not Circadian Rhythm in Male Offspring.30388025Rudar M, Fiorotto ML, Davis TAAnnual review of animal biosciencesRegulation of Muscle Growth in Early Postnatal Life in a Swine Model. Annu Rev Anim Biosci. 2019 02 15; 7:309-335.Annu Rev Anim Biosci2018-11-02T00:00:002018Regulation of Muscle Growth in Early Postnatal Life in a Swine Model.D018482Anatomy43012760.56972Muscle, SkeletalAuthorship 1049531Authorship 1087047Department of MedicineDepartment of PediatricsMedicine-NephrologyPediatrics-Critical CarePediatrics-NewbornPediatrics-NutritionBaylor College of MedicineAGUSSURYAWANAGUS SURYAWAN0.000000000000000.00000000000000109SURYAWAN, AGUSInstructorGANGAGOKULAKRISHNANGANGA GOKULAKRISHNAN0.000000000000000.000000000000001244GOKULAKRISHNAN, GANGAAssociate ProfessorRENANORELLANARENAN ORELLANA29.70508570000000-95.40180870000000201ORELLANA, RENANAssociate Professor5.115780.000755627505research areas6.328420.0048414446coauthor of181.20811.622760similar to11163selected publicationsAuthorship 1104695TERESADAVISTERESA DAVIS0.000000000000000.000000000000003169DAVIS, TERESAProfessorDOUGLASBURRINDOUGLAS BURRIN0.000000000000000.000000000000003211BURRIN, DOUGLASProfessorDENNISBIERDENNIS BIER0.000000000000000.000000000000003420BIER, DENNISProfessorMARKMANARYMARK MANARY0.000000000000000.00000000000000521MANARY, MARKAdjunct Associate ProfessorAuthorship 941525730730556Ferguson DP, Monroe TO, Heredia CP, Fleischmann R, Rodney GG, Taffet GE, Fiorotto MLThe Journal of physiologyPostnatal undernutrition alters adult female mouse cardiac structure and function leading to limited exercise capacity. J Physiol. 2019 04; 597(7):1855-1872.J Physiol2019-03-03T00:00:002019Postnatal undernutrition alters adult female mouse cardiac structure and function leading to limited exercise capacity.ROMANSHYPAILOROMAN SHYPAILO0.000000000000000.000000000000003191SHYPAILO, ROMANInstructorWILLIAMMITCHWILLIAM MITCH0.000000000000000.00000000000000900MITCH, WILLIAMDistinguished Emeritus ProfessorAuthorship 1282797Authorship 128726723545705Li G, Kohorst JJ, Zhang W, Laritsky E, Kunde-Ramamoorthy G, Baker MS, Fiorotto ML, Waterland RADiabetesEarly postnatal nutrition determines adult physical activity and energy expenditure in female mice. Diabetes. 2013 Aug; 62(8):2773-83.Diabetes2013-04-01T00:00:002013Early postnatal nutrition determines adult physical activity and energy expenditure in female mice.23736770El-Kadi SW, Gazzaneo MC, Suryawan A, Orellana RA, Torrazza RM, Srivastava N, Kimball SR, Nguyen HV, Fiorotto ML, Davis TAPediatric researchViscera and muscle protein synthesis in neonatal pigs is increased more by intermittent bolus than by continuous feeding. Pediatr Res. 2013 Aug; 74(2):154-62.Pediatr Res2013-06-04T00:00:002013Viscera and muscle protein synthesis in neonatal pigs is increased more by intermittent bolus than by continuous feeding.University of ManchesterU.K.University of Manchester, BiochemistryB.Sc. (Hons)BiochemistryUniversity of CambridgeU.K.University of Cambridge, NutritionPh.D.NutritionAuthorship 95528910Authorship 955494831503514Naberhuis JK, Suryawan A, Nguyen HV, Hernandez-Garcia A, Cruz SM, Lau PE, Olutoye OO, Stoll B, Burrin DG, Fiorotto ML, Davis TAAmerican journal of physiology. Endocrinology and metabolismPrematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets. Am J Physiol Endocrinol Metab. 2019 11 01; 317(5):E839-E851.Am J Physiol Endocrinol Metab2019-09-10T00:00:002019Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets.31518419Rudar M, Columbus DA, Steinhoff-Wagner J, Suryawan A, Nguyen HV, Fleischmann R, Davis TA, Fiorotto MLThe Journal of nutritionLeucine Supplementation Does Not Restore Diminished Skeletal Muscle Satellite Cell Abundance and Myonuclear Accretion When Protein Intake Is Limiting in Neonatal Pigs. J Nutr. 2020 01 01; 150(1):22-30.J Nutr2020-01-01T00:00:002020Leucine Supplementation Does Not Restore Diminished Skeletal Muscle Satellite Cell Abundance and Myonuclear Accretion When Protein Intake Is Limiting in Neonatal Pigs.Authorship 962022831792207MacKay H, Scott CA, Duryea JD, Baker MS, Laritsky E, Elson AE, Garland T, Fiorotto ML, Chen R, Li Y, Coarfa C, Simerly RB, Waterland RANature communicationsDNA methylation in AgRP neurons regulates voluntary exercise behavior in mice. Nat Commun. 2019 12 02; 10(1):5364.Nat Commun2019-12-02T00:00:002019DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice.Authorship 975932331944890Suryawan A, Rudar M, Fiorotto ML, Davis TAJournal of applied physiology (Bethesda, Md. : 1985)Differential regulation of mTORC1 activation by leucine and ?-hydroxy-?-methylbutyrate in skeletal muscle of neonatal pigs. J Appl Physiol (1985). 2020 02 01; 128(2):286-295.J Appl Physiol (1985)2020-01-16T00:00:002020Differential regulation of mTORC1 activation by leucine and ?-hydroxy-?-methylbutyrate in skeletal muscle of neonatal pigs.Authorship 1104673true1ProfessorProfessorAuthorship 1000070832974749Manjar?n R, Boutry-Regard C, Suryawan A, Canovas A, Piccolo BD, Maj M, Abo-Ismail M, Nguyen HV, Fiorotto ML, Davis TAAmino acidsIntermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs. Amino Acids. 2020 Sep; 52(9):1319-1335.Amino Acids2020-09-24T00:00:002020Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs.Authorship 1142763Authorship 1147004Authorship 1007981633381676El-Kadi SW, Boutry-Regard C, Suryawan A, Nguyen HV, Kimball SR, Fiorotto ML, Davis TACurrent developments in nutritionIntermittent Bolus Feeding Enhances Organ Growth More Than Continuous Feeding in a Neonatal Piglet Model. Curr Dev Nutr. 2020 Dec; 4(12):nzaa170.Curr Dev Nutr2020-11-24T00:00:002020Intermittent Bolus Feeding Enhances Organ Growth More Than Continuous Feeding in a Neonatal Piglet Model.Authorship 10086841033427053Rudar M, Naberhuis JK, Suryawan A, Nguyen HV, Stoll B, Style CC, Verla MA, Olutoye OO, Burrin DG, Fiorotto ML, Davis TAAmerican journal of physiology. Endocrinology and metabolismPrematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs. Am J Physiol Endocrinol Metab. 2021 03 01; 320(3):E551-E565.Am J Physiol Endocrinol Metab2021-01-11T00:00:002021Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs.Authorship 1157082Authorship 1204513Authorship 1013551333693751Klurfeld DM, Gregory JF, Fiorotto MLThe Journal of nutritionShould the AIN-93 Rodent Diet Formulas be Revised? J Nutr. 2021 Jun 01; 151(6):1380-1382.J Nutr2021-06-01T00:00:002021Should the AIN-93 Rodent Diet Formulas be Revised?34159368Suryawan A, El-Kadi SW, Nguyen HV, Fiorotto ML, Davis TAThe Journal of nutritionIntermittent Bolus Compared With Continuous Feeding Enhances Insulin and Amino Acid Signaling to Translation Initiation in Skeletal Muscle of Neonatal Pigs. J Nutr. 2021 09 04; 151(9):2636-2645.J Nutr2021-09-04T00:00:002021Intermittent Bolus Compared With Continuous Feeding Enhances Insulin and Amino Acid Signaling to Translation Initiation in Skeletal Muscle of Neonatal Pigs.Authorship 10237844Authorship 1029270234494085Joshi TP, Fiorotto MLThe Journal of nutritionVariation in AIN-93G/M Diets Across Different Commercial Manufacturers: Not All AIN-93 Diets are Created Equal. J Nutr. 2021 11 02; 151(11):3271-3275.J Nutr2021-11-02T00:00:002021Variation in AIN-93G/M Diets Across Different Commercial Manufacturers: Not All AIN-93 Diets are Created Equal.Authorship 1166405Authorship 117942true1Associate ProfessorAssociate ProfessorAuthorship 10334781034719946Rudar M, Naberhuis JK, Suryawan A, Nguyen HV, Stoll B, Style CC, Verla MA, Olutoye OO, Burrin DG, Fiorotto ML, Davis TAAmerican journal of physiology. Endocrinology and metabolismIntermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model. Am J Physiol Endocrinol Metab. 2021 12 01; 321(6):E737-E752.Am J Physiol Endocrinol Metab2021-11-01T00:00:002021Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model.Authorship 1036182834959747Spooner HC, Derrick SA, Maj M, Manjar?n R, Hernandez GV, Tailor DS, Bastani PS, Fanter RK, Fiorotto ML, Burrin DG, La Frano MR, Sikalidis AK, Blank JMNutrientsHigh-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease. Nutrients. 2021 Nov 23; 13(12).Nutrients2021-11-23T00:00:002021High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease.Authorship 14857Authorship 1198912true1Associate ProfessorAssociate ProfessorAuthorship 120815336128996Rudar M, Suryawan A, Nguyen HV, Chacko SK, Vonderohe C, Stoll B, Burrin DG, Fiorotto ML, Davis TAJPEN. Journal of parenteral and enteral nutritionRegulation of skeletal muscle protein synthesis in the preterm pig by intermittent leucine pulses during continuous parenteral feeding. JPEN J Parenter Enteral Nutr. 2023 02; 47(2):276-286.JPEN J Parenter Enteral Nutr2022-10-10T00:00:002022Regulation of skeletal muscle protein synthesis in the preterm pig by intermittent leucine pulses during continuous parenteral feeding.Authorship 1216381Authorship 10609275Authorship 10564144Authorship 1061032836402914Suryawan A, Rudar M, Naberhuis JK, Fiorotto ML, Davis TAPediatric researchPreterm birth alters the feeding-induced activation of Akt signaling in the muscle of neonatal piglets. Pediatr Res. 2023 Jun; 93(7):1891-1898.Pediatr Res2022-11-19T00:00:002022Preterm birth alters the feeding-induced activation of Akt signaling in the muscle of neonatal piglets.36627358Rudar M, Naberhuis JK, Suryawan A, Nguyen HV, Fiorotto ML, Davis TAPediatric researchPrematurity blunts protein synthesis in skeletal muscle independently of body weight in neonatal pigs. Pediatr Res. 2023 07; 94(1):143-152.Pediatr Res2023-01-10T00:00:002023Prematurity blunts protein synthesis in skeletal muscle independently of body weight in neonatal pigs.Authorship 178742Authorship 181423Authorship 10684151037067911Gencel-Augusto J, Su X, Qi Y, Whitley EM, Pant V, Xiong S, Shah V, Lin J, Perez E, Fiorotto ML, Mahmud I, Jain AK, Lorenzi PL, Navin NE, Richie ER, Lozano GCancer discoveryDimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program. Cancer Discov. 2023 05 04; 13(5):1230-1249.Cancer Discov2023-05-04T00:00:002023Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program.true1Distinguished Emeritus ProfessorDistinguished Emeritus ProfessorAuthorship 1085917838141773Rudar M, Suryawan A, Nguyen HV, Chacko SK, Vonderohe C, Stoll B, Burrin DG, Fiorotto ML, Davis TAThe Journal of nutritionPulsatile Leucine Administration during Continuous Enteral Feeding Enhances Skeletal Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis in a Preterm Piglet Model. J Nutr. 2024 02; 154(2):505-515.J Nutr2023-12-22T00:00:002023Pulsatile Leucine Administration during Continuous Enteral Feeding Enhances Skeletal Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis in a Preterm Piglet Model.Authorship 1086279438181968Elefson SK, Stoll B, Davis TA, Fiorotto ML, El-Kadi SW, Genovese K, Thymann T, Sangild PT, Burrin DGThe Journal of nutritionAdverse Metabolic Phenotypes in Parenterally Fed Neonatal Pigs Do Not Persist into Adolescence. J Nutr. 2024 02; 154(2):638-647.J Nutr2024-01-03T00:00:002024Adverse Metabolic Phenotypes in Parenterally Fed Neonatal Pigs Do Not Persist into Adolescence.Authorship 16566Authorship 178442Authorship 189888Authorship 224653Authorship 199801Authorship 342401Authorship 259262Authorship 271527Authorship 273752Authorship 292335Authorship 293226Authorship 288516Authorship 292512Authorship 30571Authorship 307551Authorship 142405624586653Radley-Crabb HG, Marini JC, Sosa HA, Castillo LI, Grounds MD, Fiorotto MLPloS oneDystropathology increases energy expenditure and protein turnover in the mdx mouse model of duchenne muscular dystrophy. PLoS One. 2014; 9(2):e89277.PLoS One2014-02-19T00:00:002014Dystropathology increases energy expenditure and protein turnover in the mdx mouse model of duchenne muscular dystrophy.Authorship 466322Authorship 361852Authorship 370052Authorship 390842Authorship 415232Authorship 430424Authorship 466752Authorship 633932Authorship 655654Authorship 483935Authorship 690098Authorship 513162Authorship 524713Authorship 522303Authorship 763725Authorship 768893Authorship 792504Authorship 81032Authorship 576366Authorship 1506305Authorship 150814324991043Lin L, Nuotio-Antar AM, Ma X, Liu F, Fiorotto ML, Sun YThe Journal of nutritionGhrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake. J Nutr. 2014 Sep; 144(9):1349-55.J Nutr2014-07-02T00:00:002014Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake.25056350Marini JC, Didelija IC, Fiorotto MLAmerican journal of physiology. Renal physiologyExtrarenal citrulline disposal in mice with impaired renal function. Am J Physiol Renal Physiol. 2014 Sep 15; 307(6):F660-5.Am J Physiol Renal Physiol2014-07-23T00:00:002014Extrarenal citrulline disposal in mice with impaired renal function.Authorship 649971Authorship 945111Authorship 685251Authorship 695021Authorship 717611Authorship 726303Authorship 789256Authorship 1551172