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ARUN SREEKUMAR

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry and Molecular Pharmacology
    DivisionBiochemistry & Mol Pharmacology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDuncan Cancer Center
    DivisionCancer Center


    Collapse Research 
    Collapse research activities and funding
    R01CA227904     (SREEKUMAR, ARUN ;ZHANG, XIANG)Sep 1, 2019 - Aug 31, 2024
    NIH
    Rewired Metabolism Regulates Vessel Normalization and Immunosuppression
    Role: Co-Principal Investigator
    R01CA227559     (PALAPATTU, GANESH S;SREEKUMAR, ARUN)Jul 1, 2019 - Jun 30, 2024
    NIH
    Metabolic Rewiring Promotes AA PCa by Regulating Stromal-Epithelial Interaction
    Role: Principal Investigator
    U01CA179674     (SREEKUMAR, ARUN)Sep 1, 2014 - Feb 29, 2020
    NIH
    Delineating racially distinct metabolic pathways in triple negative breast cancer
    Role: Principal Investigator
    R21CA185516     (SREEKUMAR, ARUN)Jul 1, 2014 - Jun 30, 2016
    NIH
    High Kynurenine in Agressive Triple Negative African American Breast Cancer
    Role: Principal Investigator
    U01CA167234     (SREEKUMAR, ARUN)Aug 1, 2012 - Jul 31, 2017
    NIH
    METABOLOMIC PROFILING AND BIOLOGIC BASIS OF RACIAL DISPARITY IN PROSTATE CANCER
    Role: Principal Investigator
    R03CA139489     (SREEKUMAR, ARUN)Jul 15, 2009 - May 31, 2012
    NIH
    Metabolomic Markers for Early Detection of Prostate Cancer
    Role: Principal Investigator
    R01CA133458     (SREEKUMAR, ARUN)Apr 4, 2008 - Jan 31, 2013
    NIH
    Integrative Metabolomics of Prostate Cancer Progression
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhu Q, Balasubramanian A, Asirvatham JR, Piyarathna DWB, Kaur J, Mohamed N, Wu L, Chatterjee M, Wang S, Pourfarrokh N, Rasaily U, Xu Y, Zheng J, Jebakumar D, Rao A, Chen SH, Li Y, Chang E, Li X, Aneja R, Zhang XH, Sreekumar A. Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in African American and European American patients with TNBC. bioRxiv. 2024 Mar 31. PMID: 38562769; PMCID: PMC10983891.
      Citations:    
    2. Amara CS, Kami Reddy KR, Yuntao Y, Chan YS, Piyarathna DWB, Dobrolecki LE, Shih DJH, Shi Z, Xu J, Huang S, Ellis MJ, Apolo AB, Ballester LY, Gao J, Hansel DE, Lotan Y, Hodges HC, Lerner SP, Creighton CJ, Sreekumar A, Zheng WJ, Msaouel P, Kavuri SM, Putluri N. The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer. Nat Commun. 2024 Feb 14; 15(1):1373. PMID: 38355560; PMCID: PMC10867091.
      Citations:    Fields:    Translation:HumansCells
    3. Charles C, Lloyd SM, Piyarathna DWB, Gohlke J, Rasaily U, Putluri V, Simons BW, Zaslavsky A, Nallandhighal S, Michailidis G, Palanisamy N, Navone N, Jones JA, Ittmann MM, Putluri N, Rowley DR, Salami SS, Palapattu GS, Sreekumar A. Role of adenosine deaminase in prostate cancer progression. Am J Clin Exp Urol. 2023; 11(6):594-612. PMID: 38148936; PMCID: PMC10749386.
      Citations:    
    4. Nguyen T, Sridaran D, Chouhan S, Weimholt C, Wilson A, Luo J, Li T, Koomen J, Fang B, Putluri N, Sreekumar A, Feng FY, Mahajan K, Mahajan NP. Author Correction: Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer. Nat Commun. 2023 Sep 27; 14(1):6022. PMID: 37758702; PMCID: PMC10533897.
      Citations:    Fields:    
    5. Kim BJ, Zheng ZY, Lei JT, Holt MV, Chen A, Peng J, Fandino D, Singh P, Kennedy H, Dou Y, Chica-Parrado MDR, Bikorimana E, Ye D, Wang Y, Hanker AB, Mohamed N, Hilsenbeck SG, Lim B, Asirvatham JR, Sreekumar A, Zhang B, Miles G, Anurag M, Ellis MJ, Chang EC. Proteogenomic Approaches for the Identification of NF1/Neurofibromin-depleted Estrogen Receptor-positive Breast Cancers for Targeted Treatment. Cancer Res Commun. 2023 07; 3(7):1366-1377. PMID: 37501682; PMCID: PMC10370361.
      Citations:    Translation:Humans
    6. Krieger KL, Mann EK, Lee KJ, Bolterstein E, Jebakumar D, Ittmann MM, Dal Zotto VL, Shaban M, Sreekumar A, Gassman NR. Spatial mapping of the DNA adducts in cancer. DNA Repair (Amst). 2023 08; 128:103529. PMID: 37390674; PMCID: PMC10330576.
      Citations: 1     Fields:    Translation:HumansCells
    7. Nguyen T, Sridaran D, Chouhan S, Weimholt C, Wilson A, Luo J, Li T, Koomen J, Fang B, Putluri N, Sreekumar A, Feng FY, Mahajan K, Mahajan NP. Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer. Nat Commun. 2023 06 09; 14(1):3357. PMID: 37296155; PMCID: PMC10256812.
      Citations:    Fields:    Translation:HumansCells
    8. Yang D, Patel S, Szlachcic WJ, Chmielowiec J, Scaduto D, Putluri N, Sreekumar A, Suliburk J, Metzker M, Balasubramanyam A, Borowiak M. Erratum. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes. Diabetes 2021;70:2419-2429. Diabetes. 2023 Jun 01; 72(6):821. PMID: 37067510; PMCID: PMC10202761.
      Citations:    Fields:    
    9. Chakraborty S, Cheng X, Yeo JY, Mandal J, Yang T, Mei X, Saha P, Golonka RM, Yeoh BS, Mell B, Jia W, Putluri V, Putluri N, Sreekumar A, Vijay-Kumar M, Joe B, Lulla A, Piyarathna DWB, Meyer K. Conjugated bile acids are nutritionally re-programmable antihypertensive metabolites. J Hypertens. 2023 06 01; 41(6):979-994. PMID: 37071431; PMCID: PMC10158603.
      Citations:    Fields:    Translation:HumansAnimals
    10. Ravindran A, Krieger KL, Kaushik AK, Hovington H, Mehdi S, Piyarathna DWB, Putluri V, Basil P, Rasaily U, Gu F, Dang T, Choi JM, Sonavane R, Jung SY, Wang L, Mehra R, Weigel NL, Putluri N, Rowley DR, Palapattu GS, Guillemette C, Lacombe L, L?vesque ?, Sreekumar A. Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients. Cells. 2022 07 29; 11(15). PMID: 35954173; PMCID: PMC9367340.
      Citations:    
    11. Krieger KL, Gohlke JH, Lee KJ, Piyarathna DWB, Castro PD, Jones JA, Ittmann MM, Gassman NR, Sreekumar A. Repair-Assisted Damage Detection Reveals Biological Disparities in Prostate Cancer between African Americans and European Americans. Cancers (Basel). 2022 Feb 17; 14(4). PMID: 35205762; PMCID: PMC8870190.
      Citations:    
    12. Ravindran A, Piyarathna DWB, Gohlke J, Putluri V, Soni T, Lloyd S, Castro P, Pennathur S, Jones JA, Ittmann M, Putluri N, Michailidis G, Rajendiran TM, Sreekumar A. Lipid Alterations in African American Men with Prostate Cancer. Metabolites. 2021 Dec 22; 12(1). PMID: 35050130; PMCID: PMC8779756.
      Citations: 1     
    13. Yang D, Patel S, Szlachcic WJ, Chmielowiec J, Scaduto D, Putluri N, Sreekumar A, Suliburk J, Metzker M, Balasubramanyam A, Borowiak M. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes. Diabetes. 2021 10; 70(10):2419-2429. PMID: 34344789; PMCID: PMC8576504.
      Citations:    Fields:    Translation:HumansCells
    14. Ding Y, Lee M, Gao Y, Bu P, Coarfa C, Miles B, Sreekumar A, Creighton CJ, Ayala G. Neuropeptide Y nerve paracrine regulation of prostate cancer oncogenesis and therapy resistance. Prostate. 2021 01; 81(1):58-71. PMID: 33022812; PMCID: PMC7756863.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    15. Vantaku V, Putluri V, Bader DA, Maity S, Ma J, Arnold JM, Rajapakshe K, Donepudi SR, von Rundstedt FC, Devarakonda V, Dubrulle J, Karanam B, McGuire SE, Stossi F, Jain AK, Coarfa C, Cao Q, Sikora AG, Villanueva H, Kavuri SM, Lotan Y, Sreekumar A, Putluri N. Correction: Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. Oncogene. 2020 Oct; 39(40):6387-6392. PMID: 32820250.
      Citations: 2     Fields:    
    16. Yang T, Chakraborty S, Saha P, Mell B, Cheng X, Yeo JY, Mei X, Zhou G, Mandal J, Golonka R, Yeoh BS, Putluri V, Piyarathna DWB, Putluri N, McCarthy CG, Wenceslau CF, Sreekumar A, Gewirtz AT, Vijay-Kumar M, Joe B. Gnotobiotic Rats Reveal That Gut Microbiota Regulates Colonic mRNA of Ace2, the Receptor for SARS-CoV-2 Infectivity. Hypertension. 2020 07; 76(1):e1-e3. PMID: 32426999; PMCID: PMC7379164.
      Citations: 27     Fields:    Translation:AnimalsCellsPHPublic Health
    17. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, Martin RS, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 Apr; 39(15):3226-3228. PMID: 32214199; PMCID: PMC10473373.
      Citations: 2     Fields:    
    18. Zhang X, Wang X, Wang XQD, Su J, Putluri N, Zhou T, Qu Y, Jeong M, Guzman A, Rosas C, Huang Y, Sreekumar A, Li W, Goodell MA. Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis. Blood. 2020 03 12; 135(11):845-856. PMID: 31932841; PMCID: PMC7068035.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    19. Vantaku V, Amara CS, Piyarathna DWB, Donepudi SR, Ambati CR, Putluri V, Tang W, Rajapakshe K, Estecio MR, Terris MK, Castro PD, Ittmann MM, Williams SB, Lerner SP, Sreekumar A, Bollag R, Coarfa C, Kornberg MD, Lotan Y, Ambs S, Putluri N. DNA methylation patterns in bladder tumors of African American patients point to distinct alterations in xenobiotic metabolism. Carcinogenesis. 2019 11 25; 40(11):1332-1340. PMID: 31284295; PMCID: PMC6875901.
      Citations: 3     Fields:    Translation:HumansCells
    20. Arnold J, Shivakumar V, Joseph R, Vidhya Vijay G, den Hollander P, Bhangre N, Allegakoen P, Prasad R, Conley Z, Chang JT, Vasaikar S, Soundararajan R, Sreekumar A, Mani SA, Ramirez-Pe?a E, Mat?s JM, M?rquez J. The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression. Cancers (Basel). 2019 Oct 22; 11(10). PMID: 31652551; PMCID: PMC6826439.
      Citations: 15     
    21. Piyarathna DWB, Rajendiran TM, Putluri V, Vantaku V, Soni T, von Rundstedt FC, Donepudi SR, Jin F, Maity S, Ambati CR, Dong J, Roth S, Degener S, Michailidis G, Lerner SP, Pennathur S, Lotan Y, Coarfa C, Sreekumar A, Putluri N, G?dde D, St?rkel S. Erratum to "Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder" [Eur Urol Focus 2018;4:907-915]. Eur Urol Focus. 2019 Sep; 5(5):920. PMID: 31474581.
      Citations:    Fields:    
    22. Kim IS, Gao Y, Welte T, Wang H, Liu J, Janghorban M, Sheng K, Niu Y, Goldstein A, Zhao N, Bado I, Lo HC, Toneff MJ, Nguyen T, Bu W, Jiang W, Arnold J, Gu F, He J, Jebakumar D, Walker K, Li Y, Mo Q, Westbrook TF, Zong C, Rao A, Sreekumar A, Rosen JM, Zhang XH. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019 09; 21(9):1113-1126. PMID: 31451770; PMCID: PMC6726554.
      Citations: 88     Fields:    Translation:AnimalsCells
    23. Vantaku V, Putluri V, Bader DA, Maity S, Ma J, Arnold JM, Rajapakshe K, Donepudi SR, von Rundstedt FC, Devarakonda V, Dubrulle J, Karanam B, McGuire SE, Stossi F, Jain AK, Coarfa C, Cao Q, Sikora AG, Villanueva H, Kavuri SM, Lotan Y, Sreekumar A, Putluri N. Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. Oncogene. 2020 10; 39(40):6265-6285. PMID: 31383940; PMCID: PMC8058741.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    24. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 04; 39(15):3089-3101. PMID: 31308490; PMCID: PMC6960374.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    25. Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, Park PK, Liu J, Coarfa C, Donepudi SR, Putluri V, Putluri N, Sreekumar A, Ambati CR, Hawke DH, Marks JR, Gunaratne PH, Caudle AS, Sahin AA, Hortobagyi GN, Meric-Bernstam F, Chen L, Yu D, Hung MC, Curran MA, Han L, Lin C, Yang L. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. 2019 07; 20(7):835-851. PMID: 31160797; PMCID: PMC6619502.
      Citations: 113     Fields:    Translation:HumansAnimalsCells
    26. Gohlke JH, Lloyd SM, Basu S, Putluri V, Vareed SK, Rasaily U, Piyarathna DWB, Fuentes H, Rajendiran TM, Dorsey TH, Ambati CR, Sonavane R, Karanam B, Bhowmik SK, Kittles R, Ambs S, Mims MP, Ittmann M, Jones JA, Palapattu G, Putluri N, Michailidis G, Sreekumar A. Methionine-Homocysteine Pathway in African-American Prostate Cancer. JNCI Cancer Spectr. 2019 Jun; 3(2):pkz019. PMID: 31360899; PMCID: PMC6489686.
      Citations: 8     Fields:    
    27. Piyarathna DWB, Balasubramanian A, Arnold JM, Lloyd SM, Karanam B, Castro P, Ittmann MM, Putluri N, Navone N, Jones JA, Yu W, Sandulache VC, Sikora AG, Michailidis G, Sreekumar A. ERR1 and PGC1a associated mitochondrial alterations correlate with pan-cancer disparity in African Americans. J Clin Invest. 2019 03 28; 129(6):2351-2356. PMID: 30920960; PMCID: PMC6546480.
      Citations: 11     Fields:    Translation:HumansCells
    28. Vantaku V, Dong J, Ambati CR, Perera D, Donepudi SR, Amara CS, Putluri V, Ravi SS, Robertson MJ, Piyarathna DWB, Villanueva M, von Rundstedt FC, Karanam B, Ballester LY, Terris MK, Bollag RJ, Lerner SP, Apolo AB, Villanueva H, Lee M, Sikora AG, Lotan Y, Sreekumar A, Coarfa C, Putluri N. Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer. Clin Cancer Res. 2019 06 15; 25(12):3689-3701. PMID: 30846479; PMCID: PMC6571061.
      Citations: 39     Fields:    Translation:HumansCells
    29. Fischer GM, Jalali A, Kircher DA, Lee WC, McQuade JL, Haydu LE, Joon AY, Reuben A, Carapeto FCL, Yang C, Srivastava A, Ambati CR, Sreekumar A, Hudgens CW, Knighton B, Deng W, Ferguson SD, Tawbi HA, Glitza IC, Gershenwald JE, Vashisht Gopal YN, Hwu P, Huse JT, Wargo JA, Futreal PA, Putluri N, Lazar AJ, DeBerardinis RJ, Marszalek JR, Zhang J, Holmen SL, Tetzlaff MT, Davies MA, de Macedo MP. Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases. Cancer Discov. 2019 05; 9(5):628-645. PMID: 30787016; PMCID: PMC6497554.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    30. Amara CS, Ambati CR, Vantaku V, Badrajee Piyarathna DW, Donepudi SR, Ravi SS, Arnold JM, Putluri V, Chatta G, Guru KA, Badr H, Terris MK, Bollag RJ, Sreekumar A, Apolo AB, Putluri N. Serum Metabolic Profiling Identified a Distinct Metabolic Signature in Bladder Cancer Smokers: A Key Metabolic Enzyme Associated with Patient Survival. Cancer Epidemiol Biomarkers Prev. 2019 04; 28(4):770-781. PMID: 30642841; PMCID: PMC6449217.
      Citations: 13     Fields:    Translation:Humans
    31. Vantaku V, Donepudi SR, Piyarathna DWB, Amara CS, Ambati CR, Tang W, Putluri V, Chandrashekar DS, Varambally S, Terris MK, Davies K, Ambs S, Bollag R, Apolo AB, Sreekumar A, Putluri N. Large-scale profiling of serum metabolites in African American and European American patients with bladder cancer reveals metabolic pathways associated with patient survival. Cancer. 2019 03 15; 125(6):921-932. PMID: 30602056; PMCID: PMC6402983.
      Citations: 17     Fields:    Translation:Humans
    32. Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SE. Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer. Nat Metab. 2019 01; 1(1):70-85. PMID: 31198906; PMCID: PMC6563330.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    33. Ambati CR, Vantaku V, Donepudi SR, Amara CS, Ravi SS, Mandalapu A, Perla M, Putluri V, Sreekumar A, Putluri N. Measurement of methylated metabolites using Liquid Chromatography-Mass Spectrometry and its biological application. Anal Methods. 2019 Jan 07; 11(1):49-57. PMID: 31762797; PMCID: PMC6874373.
      Citations: 4     Fields:    
    34. Khan V, Putluri N, Sreekumar A, Mindikoglu AL. Current Applications of Metabolomics in Cirrhosis. Metabolites. 2018 Oct 22; 8(4). PMID: 30360420; PMCID: PMC6316274.
      Citations: 3     
    35. Viswanathan M, Duncan R, Grigortsuk M, Sreekumar A. A Bottom-Up Approach to Understanding Low-Income Patients: Implications for Health-Related Policy. J Law Med Ethics. 2018 Sep; 46(3):658-664. PMID: 30336095.
      Citations: 1     Fields:    Translation:Humans
    36. Ballester LY, Lu G, Zorofchian S, Vantaku V, Putluri V, Yan Y, Arevalo O, Zhu P, Riascos RF, Sreekumar A, Esquenazi Y, Putluri N, Zhu JJ. Analysis of cerebrospinal fluid metabolites in patients with primary or metastatic central nervous system tumors. Acta Neuropathol Commun. 2018 08 31; 6(1):85. PMID: 30170631; PMCID: PMC6117959.
      Citations: 17     Fields:    Translation:Humans
    37. Purwaha P, Gu F, Piyarathna DWB, Rajendiran T, Ravindran A, Omilian AR, Jiralerspong S, Das G, Morrison C, Ambrosone C, Coarfa C, Putluri N, Sreekumar A. Unbiased Lipidomic Profiling of Triple-Negative Breast Cancer Tissues Reveals the Association of Sphingomyelin Levels with Patient Disease-Free Survival. Metabolites. 2018 Jul 13; 8(3). PMID: 30011843; PMCID: PMC6161031.
      Citations: 11     
    38. Xing Z, Zhang Y, Liang K, Yan L, Xiang Y, Li C, Hu Q, Jin F, Putluri V, Putluri N, Coarfa C, Sreekumar A, Park PK, Nguyen TK, Wang S, Zhou J, Zhou Y, Marks JR, Hawke DH, Hung MC, Yang L, Han L, Ying H, Lin C. Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer. Cancer Res. 2018 08 15; 78(16):4524-4532. PMID: 29967256; PMCID: PMC6126676.
      Citations: 32     Fields:    Translation:HumansCells
    39. Dai C, Arceo J, Arnold J, Sreekumar A, Dovichi NJ, Li J, Littlepage LE. Metabolomics of oncogene-specific metabolic reprogramming during breast cancer. Cancer Metab. 2018; 6:5. PMID: 29619217; PMCID: PMC5881178.
      Citations: 17     
    40. Yu W, Chen Y, Dubrulle J, Stossi F, Putluri V, Sreekumar A, Putluri N, Baluya D, Lai SY, Sandulache VC. Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism. Sci Rep. 2018 03 09; 8(1):4306. PMID: 29523854; PMCID: PMC5844883.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    41. White MA, Tsouko E, Lin C, Rajapakshe K, Spencer JM, Wilkenfeld SR, Vakili SS, Pulliam TL, Awad D, Nikolos F, Katreddy RR, Kaipparettu BA, Sreekumar A, Zhang X, Cheung E, Coarfa C, Frigo DE. GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling. Endocr Relat Cancer. 2018 04; 25(4):453-469. PMID: 29431615; PMCID: PMC5831527.
      Citations: 19     Fields:    Translation:HumansCells
    42. Lisewski AM, Quiros JP, Mittal M, Putluri N, Sreekumar A, Lichtarge O, Haeggstr?m JZ. Potential role of Plasmodium falciparum exported protein 1 in the chloroquine mode of action. Int J Parasitol Drugs Drug Resist. 2018 04; 8(1):31-35. PMID: 29324251; PMCID: PMC5963095.
      Citations: 4     Fields:    Translation:HumansAnimals
    43. Mishra P, Tang W, Putluri V, Dorsey TH, Jin F, Wang F, Zhu D, Amable L, Deng T, Zhang S, Killian JK, Wang Y, Minas TZ, Yfantis HG, Lee DH, Sreekumar A, Bustin M, Liu W, Putluri N, Ambs S. ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming. J Clin Invest. 2018 01 02; 128(1):323-340. PMID: 29202474; PMCID: PMC5749504.
      Citations: 32     Fields:    Translation:HumansCells
    44. Coarfa C, Florentin D, Putluri N, Ding Y, Au J, He D, Ragheb A, Frolov A, Michailidis G, Lee M, Kadmon D, Miles B, Smith C, Ittmann M, Rowley D, Sreekumar A, Creighton CJ, Ayala G. Influence of the neural microenvironment on prostate cancer. Prostate. 2018 Feb; 78(2):128-139. PMID: 29131367; PMCID: PMC5836952.
      Citations: 24     Fields:    Translation:Animals
    45. Jin F, Thaiparambil J, Donepudi SR, Vantaku V, Piyarathna DWB, Maity S, Krishnapuram R, Putluri V, Gu F, Purwaha P, Bhowmik SK, Ambati CR, von Rundstedt FC, Roghmann F, Berg S, Noldus J, Rajapakshe K, Roth S, Degener S, Michailidis G, Kaipparettu BA, Karanam B, Terris MK, Kavuri SM, Lerner SP, Kheradmand F, Coarfa C, Sreekumar A, Lotan Y, El-Zein R, Putluri N, G?dde D, St?rkel S. Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer. Cancer Prev Res (Phila). 2017 Oct; 10(10):588-597. PMID: 28851690; PMCID: PMC5626664.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    46. Piyarathna DWB, Rajendiran TM, Putluri V, Vantaku V, Soni T, von Rundstedt FC, Donepudi SR, Jin F, Maity S, Ambati CR, Dong J, Roth S, Degener S, Michailidis G, Lerner SP, Pennathur S, Lotan Y, Coarfa C, Sreekumar A, Putluri N, G?dde D, St?rkel S. Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder. Eur Urol Focus. 2018 12; 4(6):907-915. PMID: 28753886; PMCID: PMC5650548.
      Citations: 23     Fields:    Translation:Humans
    47. Tian L, Goldstein A, Wang H, Ching Lo H, Sun Kim I, Welte T, Sheng K, Dobrolecki LE, Zhang X, Putluri N, Phung TL, Mani SA, Stossi F, Sreekumar A, Mancini MA, Decker WK, Zong C, Lewis MT, Zhang XH. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature. 2017 04 13; 544(7649):250-254. PMID: 28371798; PMCID: PMC5788037.
      Citations: 237     Fields:    Translation:HumansAnimalsCells
    48. Noonepalle SK, Gu F, Lee EJ, Choi JH, Han Q, Kim J, Ouzounova M, Shull AY, Pei L, Hsu PY, Kolhe R, Shi F, Choi J, Chiou K, Huang TH, Korkaya H, Deng L, Xin HB, Huang S, Thangaraju M, Sreekumar A, Ambs S, Tang SC, Munn DH, Shi H. Promoter Methylation Modulates Indoleamine 2,3-Dioxygenase 1 Induction by Activated T Cells in Human Breast Cancers. Cancer Immunol Res. 2017 04; 5(4):330-344. PMID: 28264810; PMCID: PMC5493476.
      Citations: 17     Fields:    Translation:HumansCells
    49. Yoon WH, Sandoval H, Nagarkar-Jaiswal S, Jaiswal M, Yamamoto S, Haelterman NA, Putluri N, Putluri V, Sreekumar A, Tos T, Aksoy A, Donti T, Graham BH, Ohno M, Nishi E, Hunter J, Muzny DM, Carmichael J, Shen J, Arboleda VA, Nelson SF, Wangler MF, Karaca E, Lupski JR, Bellen HJ. Loss of Nardilysin, a Mitochondrial Co-chaperone for a-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration. Neuron. 2017 Jan 04; 93(1):115-131. PMID: 28017472; PMCID: PMC5242142.
      Citations: 55     Fields:    Translation:AnimalsCells
    50. Kettner NM, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L. Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis. Cancer Cell. 2016 Dec 12; 30(6):909-924. PMID: 27889186; PMCID: PMC5695235.
      Citations: 141     Fields:    Translation:HumansAnimals
    51. Zhang L, Wang J, Wang Y, Zhang Y, Castro P, Shao L, Sreekumar A, Putluri N, Guha N, Deepak S, Padmanaban A, Creighton CJ, Ittmann M. MNX1 Is Oncogenically Upregulated in African-American Prostate Cancer. Cancer Res. 2016 11 01; 76(21):6290-6298. PMID: 27578002; PMCID: PMC5093064.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    52. Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, Zaslavsky A, Putluri V, Vasu VT, Zhang Y, Khan AS, Lloyd S, Szafran AT, Dasgupta S, Bader DA, Stossi F, Li H, Samanta S, Cao X, Tsouko E, Huang S, Frigo DE, Chan L, Edwards DP, Kaipparettu BA, Mitsiades N, Weigel NL, Mancini M, McGuire SE, Mehra R, Ittmann MM, Chinnaiyan AM, Putluri N, Palapattu GS, Michailidis G, Sreekumar A. Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer. Nat Commun. 2016 05 19; 7:11612. PMID: 27194471; PMCID: PMC4874037.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    53. Stossi F, Dandekar RD, Bolt MJ, Newberg JY, Mancini MG, Kaushik AK, Putluri V, Sreekumar A, Mancini MA. High throughput microscopy identifies bisphenol AP, a bisphenol A analog, as a novel AR down-regulator. Oncotarget. 2016 Mar 29; 7(13):16962-74. PMID: 26918604; PMCID: PMC4941363.
      Citations: 8     Fields:    Translation:HumansCells
    54. Kaushik AK, Sreekumar A. Genomic Aberrations Drive Clonal Evolution of Neuroendocrine Tumors. Trends Endocrinol Metab. 2016 05; 27(5):242-244. PMID: 27037211.
      Citations:    Fields:    Translation:HumansAnimalsCells
    55. Park JH, Vithayathil S, Kumar S, Sung PL, Dobrolecki LE, Putluri V, Bhat VB, Bhowmik SK, Gupta V, Arora K, Wu D, Tsouko E, Zhang Y, Maity S, Donti TR, Graham BH, Frigo DE, Coarfa C, Yotnda P, Putluri N, Sreekumar A, Lewis MT, Creighton CJ, Wong LC, Kaipparettu BA. Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer. Cell Rep. 2016 Mar 08; 14(9):2154-2165. PMID: 26923594; PMCID: PMC4809061.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    56. von Rundstedt FC, Rajapakshe K, Ma J, Arnold JM, Gohlke J, Putluri V, Krishnapuram R, Piyarathna DB, Lotan Y, Roth S, Levitt JM, Michailidis G, Sreekumar A, Lerner SP, Coarfa C, Putluri N, G?dde D, St?rkel S. Integrative Pathway Analysis of Metabolic Signature in Bladder Cancer: A Linkage to The Cancer Genome Atlas Project and Prediction of Survival. J Urol. 2016 06; 195(6):1911-9. PMID: 26802582; PMCID: PMC4861129.
      Citations: 21     Fields:    Translation:HumansCells
    57. Prueitt RL, Wallace TA, Glynn SA, Yi M, Tang W, Luo J, Dorsey TH, Stagliano KE, Gillespie JW, Hudson RS, Terunuma A, Shoe JL, Haines DC, Yfantis HG, Han M, Martin DN, Jordan SV, Borin JF, Naslund MJ, Alexander RB, Stephens RM, Loffredo CA, Lee DH, Putluri N, Sreekumar A, Hurwitz AA, Ambs S. An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers. Cancer Res. 2016 Mar 01; 76(5):1055-1065. PMID: 26719530; PMCID: PMC4775384.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    58. Bhowmik SK, Arnold JM, Putluri V, Sphyris N, Michailidis G, Putluri N, Ambs S, Sreekumar A, Mani SA, Ramirez-Pe?a E. EMT-induced metabolite signature identifies poor clinical outcome. Oncotarget. 2015 Dec 15; 6(40):42651-60. PMID: 26315396; PMCID: PMC4767460.
      Citations: 24     Fields:    Translation:HumansCells
    59. Shafi AA, Putluri V, Arnold JM, Tsouko E, Maity S, Roberts JM, Coarfa C, Frigo DE, Putluri N, Sreekumar A, Weigel NL. Differential regulation of metabolic pathways by androgen receptor (AR) and its constitutively active splice variant, AR-V7, in prostate cancer cells. Oncotarget. 2015 Oct 13; 6(31):31997-2012. PMID: 26378018; PMCID: PMC4741655.
      Citations: 43     Fields:    Translation:HumansCells
    60. Bhowmik SK, Putluri V, Kommagani R, Konde SA, Lydon JP, Sreekumar A, Putluri N. Application of (13) C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation. J Mass Spectrom. 2015 Oct; 50(10):1180. PMID: 26456788.
      Citations:    Fields:    
    61. Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW. Correction: Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization. PLoS Genet. 2015 Sep; 11(9):e1005515. PMID: 26418340; PMCID: PMC4587844.
      Citations: 1     Fields:    
    62. Jin F, Bhowmik SK, Putluri V, Gu F, Gohlke J, Von Rundstedt FC, Dasgupta S, Krishnapuram R, O'Malley BW, Sreekumar A, Putluri N. A Novel [15N] Glutamine Flux using LC-MS/MS-SRM for Determination of Nucleosides and Nucleobases. J Anal Bioanal Tech. 2015 Oct; 6(5). PMID: 27158554; PMCID: PMC4857768.
      Citations: 1     
    63. Lloyd SM, Arnold J, Sreekumar A. Metabolomic profiling of hormone-dependent cancers: a bird's eye view. Trends Endocrinol Metab. 2015 Sep; 26(9):477-85. PMID: 26242817; PMCID: PMC4560106.
      Citations: 19     Fields:    Translation:Humans
    64. Naresh KN, Sreekumar A, Rajan SS. Structural insights into the interaction between molluscan hemocyanins and phenolic substrates: An in silico study using docking and molecular dynamics. J Mol Graph Model. 2015 Sep; 61:272-80. PMID: 26300244.
      Citations: 3     Fields:    Translation:AnimalsCells
    65. Zaslavsky AB, Gloeckner-Kalousek A, Adams M, Putluri N, Venghatakrishnan H, Li H, Morgan TM, Feng FY, Tewari M, Sreekumar A, Palapattu GS. Platelet-Synthesized Testosterone in Men with Prostate Cancer Induces Androgen Receptor Signaling. Neoplasia. 2015 Jun; 17(6):490-6. PMID: 26152357; PMCID: PMC4719002.
      Citations: 3     Fields:    Translation:HumansCells
    66. Kang YK, Putluri N, Maity S, Tsimelzon A, Ilkayeva O, Mo Q, Lonard D, Michailidis G, Sreekumar A, Newgard CB, Wang M, Tsai SY, Tsai MJ, O'Malley BW. CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-a-Gabpa and stress-induced adaptive responses via NF-?B-cMYC. PLoS Genet. 2015 Apr; 11(4):e1005116. PMID: 25830341; PMCID: PMC4382186.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    67. Arnold JM, Choi WT, Sreekumar A, Maletic-Savatic M. Analytical strategies for studying stem cell metabolism. Front Biol (Beijing). 2015 Apr; 10(2):141-153. PMID: 26213533; PMCID: PMC4512307.
      Citations: 7     
    68. Dytfeld D, Rosebeck S, Kandarpa M, Mayampurath A, Mellacheruvu D, Alonge MM, Ngoka L, Jasielec J, Richardson PG, Volchenboum S, Nesvizhskii AI, Sreekumar A, Jakubowiak AJ. Proteomic profiling of na?ve multiple myeloma patient plasma cells identifies pathways associated with favourable response to bortezomib-based treatment regimens. Br J Haematol. 2015 Jul; 170(1):66-79. PMID: 25824111.
      Citations: 9     Fields:    Translation:HumansCellsCTClinical Trials
    69. Dasgupta S, Putluri N, Long W, Zhang B, Wang J, Kaushik AK, Arnold JM, Bhowmik SK, Stashi E, Brennan CA, Rajapakshe K, Coarfa C, Mitsiades N, Ittmann MM, Chinnaiyan AM, Sreekumar A, O'Malley BW. Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. J Clin Invest. 2015 Mar 02; 125(3):1174-88. PMID: 25664849; PMCID: PMC4362260.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    70. Lisewski AM, Quiros JP, Ng CL, Adikesavan AK, Putluri N, Scanfeld D, Regenbogen SJ, Sreekumar A, Fidock DA, Lichtarge O, Miura K, Eastman RT, Altenhofen L, Llin?s M, Long C. Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell. 2014 Aug 14; 158(4):916-928. PMID: 25126794; PMCID: PMC4167585.
      Citations: 53     Fields:    Translation:AnimalsCells
    71. Putluri N, Maity S, Kommagani R, Kommangani R, Creighton CJ, Putluri V, Chen F, Nanda S, Bhowmik SK, Terunuma A, Dorsey T, Nardone A, Fu X, Shaw C, Sarkar TR, Schiff R, Lydon JP, O'Malley BW, Ambs S, Das GM, Michailidis G, Sreekumar A. Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance. Neoplasia. 2014 May; 16(5):390-402. PMID: 25016594; PMCID: PMC4198742.
      Citations: 37     Fields:    Translation:HumansCells
    72. Narayanan SP, Xu Z, Putluri N, Sreekumar A, Lemtalsi T, Caldwell RW, Caldwell RB. Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism. Cell Death Dis. 2014 Feb 20; 5:e1075. PMID: 24556690; PMCID: PMC3944241.
      Citations: 35     Fields:    Translation:AnimalsCells
    73. Stashi E, Lanz RB, Mao J, Michailidis G, Zhu B, Kettner NM, Putluri N, Reineke EL, Reineke LC, Dasgupta S, Dean A, Stevenson CR, Sivasubramanian N, Sreekumar A, Demayo F, York B, Fu L, O'Malley BW. SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm. Cell Rep. 2014 Feb 27; 6(4):633-45. PMID: 24529706; PMCID: PMC4096300.
      Citations: 41     Fields:    Translation:AnimalsCells
    74. Vareed SK, Basu S, Putluri V, Putluri N, Panzitt K, Brennan CA, Chinnaiyan AM, Vergara IA, Erho N, Weigel NL, Mitsiades N, Shojaie A, Palapattu G, Michailidis G, Sreekumar A, Kaushik AK. Metabolomic profiling identifies biochemical pathways associated with castration-resistant prostate cancer. J Proteome Res. 2014 Feb 07; 13(2):1088-100. PMID: 24359151; PMCID: PMC3975657.
      Citations: 25     Fields:    Translation:HumansCells
    75. Terunuma A, Putluri N, Mishra P, Dorsey TH, Yi M, Wallace TA, Issaq HJ, Zhou M, Killian JK, Stevenson HS, Karoly ED, Chan K, Samanta S, Prieto D, Hsu TY, Kurley SJ, Putluri V, Sonavane R, Edelman DC, Wulff J, Starks AM, Yang Y, Kittles RA, Yfantis HG, Lee DH, Ioffe OB, Schiff R, Stephens RM, Meltzer PS, Veenstra TD, Westbrook TF, Sreekumar A, Ambs S, Math? EA. MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis. J Clin Invest. 2014 Jan; 124(1):398-412. PMID: 24316975; PMCID: PMC3871244.
      Citations: 206     Fields:    Translation:HumansCells
    76. Bhowmik SK, Putluri V, Kommagani R, Konde SA, Lydon JP, Sreekumar A, Putluri N. Application of 13C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation. J Mass Spectrom. 2013 Dec; 48(12):1270-5. PMID: 24338880.
      Citations:    Fields:    Translation:HumansCells
    77. Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW. Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization. PLoS Genet. 2013 Oct; 9(10):e1003900. PMID: 24204309; PMCID: PMC3812085.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    78. Khan AP, Rajendiran TM, Ateeq B, Asangani IA, Athanikar JN, Yocum AK, Mehra R, Siddiqui J, Palapattu G, Wei JT, Michailidis G, Sreekumar A, Chinnaiyan AM. The role of sarcosine metabolism in prostate cancer progression. Neoplasia. 2013 May; 15(5):491-501. PMID: 23633921; PMCID: PMC3638352.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    79. Homer CR, Kabi A, Sreekumar A, Nesvizhskii AI, Nickerson KP, Chinnaiyan AM, McDonald C, Marina-Garc?a N, Nu?ez G. A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy. J Biol Chem. 2012 Jul 20; 287(30):25565-76. PMID: 22665475; PMCID: PMC3408141.
      Citations: 39     Fields:    Translation:HumansCells
    80. Poisson LM, Sreekumar A, Chinnaiyan AM, Ghosh D. Pathway-directed weighted testing procedures for the integrative analysis of gene expression and metabolomic data. Genomics. 2012 May; 99(5):265-74. PMID: 22497771; PMCID: PMC3525328.
      Citations: 7     Fields:    Translation:Humans
    81. Richmond AL, Kabi A, Homer CR, Nickerson KP, Nesvizhskii AI, Sreekumar A, Chinnaiyan AM, McDonald C, Marina-Garc?a N, Nu?ez G. The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells. Gastroenterology. 2012 Jun; 142(7):1483-92.e6. PMID: 22387394; PMCID: PMC3565430.
      Citations: 18     Fields:    Translation:HumansCells
    82. Putluri N, Shojaie A, Vasu VT, Vareed SK, Nalluri S, Putluri V, Thangjam GS, Panzitt K, Tallman CT, Butler C, Sana TR, Fischer SM, Sica G, Brat DJ, Shi H, Palapattu GS, Lotan Y, Weizer AZ, Terris MK, Shariat SF, Michailidis G, Sreekumar A. Metabolomic profiling reveals potential markers and bioprocesses altered in bladder cancer progression. Cancer Res. 2011 Dec 15; 71(24):7376-86. PMID: 21990318; PMCID: PMC3249241.
      Citations: 74     Fields:    Translation:HumansCells
    83. Putluri N, Shojaie A, Vasu VT, Nalluri S, Vareed SK, Putluri V, Vivekanandan-Giri A, Byun J, Pennathur S, Sana TR, Fischer SM, Palapattu GS, Creighton CJ, Michailidis G, Sreekumar A. Metabolomic profiling reveals a role for androgen in activating amino acid metabolism and methylation in prostate cancer cells. PLoS One. 2011; 6(7):e21417. PMID: 21789170; PMCID: PMC3138744.
      Citations: 42     Fields:    Translation:HumansCells
    84. Choudhary V, Kaddour-Djebbar I, Lakshmikanthan V, Ghazaly T, Thangjam GS, Sreekumar A, Lewis RW, Mills IG, Bollag WB, Kumar MV. Novel role of androgens in mitochondrial fission and apoptosis. Mol Cancer Res. 2011 Aug; 9(8):1067-77. PMID: 21724752; PMCID: PMC3290867.
      Citations: 19     Fields:    Translation:HumansCells
    85. Vareed SK, Bhat VB, Thompson C, Vasu VT, Fermin D, Choi H, Creighton CJ, Gayatri S, Lan L, Putluri N, Thangjam GS, Kaur P, Shabahang M, Giri JG, Nesvizhskii AI, Asea AA, Cashikar AG, Rao A, McLoughlin J, Sreekumar A. Metabolites of purine nucleoside phosphorylase (NP) in serum have the potential to delineate pancreatic adenocarcinoma. PLoS One. 2011 Mar 23; 6(3):e17177. PMID: 21448452; PMCID: PMC3063153.
      Citations: 8     Fields:    Translation:Humans
    86. Choi JH, Li Y, Guo J, Pei L, Rauch TA, Kramer RS, Macmil SL, Wiley GB, Bennett LB, Schnabel JL, Taylor KH, Kim S, Xu D, Sreekumar A, Pfeifer GP, Roe BA, Caldwell CW, Bhalla KN, Shi H. Genome-wide DNA methylation maps in follicular lymphoma cells determined by methylation-enriched bisulfite sequencing. PLoS One. 2010 Sep 29; 5(9). PMID: 20927367; PMCID: PMC2947499.
      Citations: 20     Fields:    Translation:HumansCells
    87. Vellaichamy A, JeBailey L, Chinnaiyan AM, Sreekumar A, Nesvizhskii AI, Omenn GS, Bugrim A, Dezso Z. "Topological significance" analysis of gene expression and proteomic profiles from prostate cancer cells reveals key mechanisms of androgen response. PLoS One. 2010 Jun 03; 5(6):e10936. PMID: 20532174; PMCID: PMC2880599.
      Citations: 23     Fields:    Translation:HumansCells
    88. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghoshd D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM. Re: Florian Jentzmik, Carsten Stephan, Kurt Miller, et al. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours. Eur Urol 2010;58:12-8. Eur Urol. 2010 Sep; 58(3):e29-30; author reply e31-2. PMID: 20537788; PMCID: PMC3919522.
      Citations: 5     Fields:    Translation:Humans
    89. Mariappa D, Aladakatti RH, Dasari SK, Sreekumar A, Wolkowicz M, van der Hoorn F, Seshagiri PB. Inhibition of tyrosine phosphorylation of sperm flagellar proteins, outer dense fiber protein-2 and tektin-2, is associated with impaired motility during capacitation of hamster spermatozoa. Mol Reprod Dev. 2010 Feb; 77(2):182-93. PMID: 19953638.
      Citations: 15     Fields:    Translation:AnimalsCells
    90. Khan AP, Poisson LM, Bhat VB, Fermin D, Zhao R, Kalyana-Sundaram S, Michailidis G, Nesvizhskii AI, Omenn GS, Chinnaiyan AM, Sreekumar A. Quantitative proteomic profiling of prostate cancer reveals a role for miR-128 in prostate cancer. Mol Cell Proteomics. 2010 Feb; 9(2):298-312. PMID: 19955085; PMCID: PMC2830841.
      Citations: 55     Fields:    Translation:HumansCells
    91. Vellaichamy A, Sreekumar A, Strahler JR, Rajendiran T, Yu J, Varambally S, Li Y, Omenn GS, Chinnaiyan AM, Nesvizhskii AI. Proteomic interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetases. PLoS One. 2009 Sep 18; 4(9):e7075. PMID: 19763266; PMCID: PMC2740864.
      Citations: 26     Fields:    Translation:HumansCells
    92. Fiskus W, Wang Y, Sreekumar A, Buckley KM, Shi H, Jillella A, Ustun C, Rao R, Fernandez P, Chen J, Balusu R, Koul S, Atadja P, Marquez VE, Bhalla KN. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood. 2009 Sep 24; 114(13):2733-43. PMID: 19638619; PMCID: PMC2756128.
      Citations: 164     Fields:    Translation:HumansCells
    93. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12; 457(7231):910-4. PMID: 19212411; PMCID: PMC2724746.
      Citations: 745     Fields:    Translation:HumansCells
    94. Varambally S, Laxman B, Mehra R, Cao Q, Dhanasekaran SM, Tomlins SA, Granger J, Vellaichamy A, Sreekumar A, Yu J, Gu W, Shen R, Ghosh D, Wright LM, Kladney RD, Kuefer R, Rubin MA, Fimmel CJ, Chinnaiyan AM. Golgi protein GOLM1 is a tissue and urine biomarker of prostate cancer. Neoplasia. 2008 Nov; 10(11):1285-94. PMID: 18953438; PMCID: PMC2570605.
      Citations: 43     Fields:    Translation:HumansCells
    95. Krupanidhi S, Sreekumar A, Sanjeevi CB. Copper & biological health. Indian J Med Res. 2008 Oct; 128(4):448-61. PMID: 19106440.
      Citations: 11     Fields:    Translation:Humans
    96. Taylor BS, Pal M, Yu J, Laxman B, Kalyana-Sundaram S, Zhao R, Menon A, Wei JT, Nesvizhskii AI, Ghosh D, Omenn GS, Lubman DM, Chinnaiyan AM, Sreekumar A. Humoral response profiling reveals pathways to prostate cancer progression. Mol Cell Proteomics. 2008 Mar; 7(3):600-11. PMID: 18077443.
      Citations: 26     Fields:    Translation:Humans
    97. Mueller D, Bach C, Zeisig D, Garcia-Cuellar MP, Monroe S, Sreekumar A, Zhou R, Nesvizhskii A, Chinnaiyan A, Hess JL, Slany RK. A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood. 2007 Dec 15; 110(13):4445-54. PMID: 17855633; PMCID: PMC2234781.
      Citations: 197     Fields:    Translation:HumansAnimalsCells
    98. Pal M, Moffa A, Sreekumar A, Ethier SP, Barder TJ, Chinnaiyan A, Lubman DM. Differential phosphoprotein mapping in cancer cells using protein microarrays produced from 2-D liquid fractionation. Anal Chem. 2006 Feb 01; 78(3):702-10. PMID: 16448042.
      Citations: 6     Fields:    Translation:HumansCells
    99. Finn WG, Sreekumar A, Menon A, Utiger C, Chinnaiyan A. Trisomy 12-associated, t(11;14)-negative mature B-cell leukemia with gene expression profile resembling mantle cell lymphoma. Leuk Lymphoma. 2006 Jan; 47(1):121-7. PMID: 16321836.
      Citations: 2     Fields:    Translation:HumansCells
    100. Wang X, Yu J, Sreekumar A, Varambally S, Shen R, Giacherio D, Mehra R, Montie JE, Pienta KJ, Sanda MG, Kantoff PW, Rubin MA, Wei JT, Ghosh D, Chinnaiyan AM. Autoantibody signatures in prostate cancer. N Engl J Med. 2005 Sep 22; 353(12):1224-35. PMID: 16177248.
      Citations: 207     Fields:    Translation:HumansCells
    101. Olle EW, Sreekumar A, Warner RL, McClintock SD, Chinnaiyan AM, Bleavins MR, Anderson TD, Johnson KJ. Development of an internally controlled antibody microarray. Mol Cell Proteomics. 2005 Nov; 4(11):1664-72. PMID: 16041058.
      Citations: 7     Fields:    Translation:AnimalsCells
    102. Bradley SV, Oravecz-Wilson KI, Bougeard G, Mizukami I, Li L, Munaco AJ, Sreekumar A, Corradetti MN, Chinnaiyan AM, Sanda MG, Ross TS. Serum antibodies to huntingtin interacting protein-1: a new blood test for prostate cancer. Cancer Res. 2005 May 15; 65(10):4126-33. PMID: 15899803.
      Citations: 16     Fields:    Translation:HumansAnimals
    103. Sreekumar A, Acharya KK, Lalitha HS, Indi SS, Bali P, Seshagiri PB. Germ cell-specific localization of immunoreactive riboflavin carrier protein in the male golden hamster: appearance during spermatogenesis and role in sperm function. Reproduction. 2005 May; 129(5):577-87. PMID: 15855621.
      Citations: 1     Fields:    Translation:AnimalsCells
    104. Sreekumar A, Laxman B, Rhodes DR, Bhagavathula S, Harwood J, Giacherio D, Ghosh D, Sanda MG, Rubin MA, Chinnaiyan AM. Humoral immune response to alpha-methylacyl-CoA racemase and prostate cancer. J Natl Cancer Inst. 2004 Jun 02; 96(11):834-43. PMID: 15173267.
      Citations: 37     Fields:    Translation:Humans
    105. Nyati MK, Maheshwari D, Hanasoge S, Sreekumar A, Rynkiewicz SD, Chinnaiyan AM, Leopold WR, Ethier SP, Lawrence TS. Radiosensitization by pan ErbB inhibitor CI-1033 in vitro and in vivo. Clin Cancer Res. 2004 Jan 15; 10(2):691-700. PMID: 14760092.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    106. Knight PR, Sreekumar A, Siddiqui J, Laxman B, Copeland S, Chinnaiyan A, Remick DG. Development of a sensitive microarray immunoassay and comparison with standard enzyme-linked immunoassay for cytokine analysis. Shock. 2004 Jan; 21(1):26-30. PMID: 14676680.
      Citations: 26     Fields:    Translation:Humans
    107. Yan F, Sreekumar A, Laxman B, Chinnaiyan AM, Lubman DM, Barder TJ. Protein microarrays using liquid phase fractionation of cell lysates. Proteomics. 2003 Jul; 3(7):1228-35. PMID: 12872223.
      Citations: 10     Fields:    Translation:HumansCells
    108. Seshagiri PB, Thomas M, Sreekumar A, Ray P, Mariappa D. Pentoxifylline induced signalling events during capacitation of hamster spermatozoa: significance of protein tyrosine phosphorylation. Cell Mol Biol (Noisy-le-grand). 2003 May; 49(3):371-80. PMID: 12887089.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    109. Sreekumar A, Chinnaiyan AM. Protein microarrays: a powerful tool to study cancer. Curr Opin Mol Ther. 2002 Dec; 4(6):587-93. PMID: 12596361.
      Citations: 1     Fields:    Translation:HumansAnimals
    110. Sreekumar A, Chinnaiyan AM. Using protein microarrays to study cancer. Biotechniques. 2002 Dec; Suppl:46-53. PMID: 12514929.
      Citations: 2     Fields:    Translation:HumansAnimals
    111. Sreekumar A, Nyati MK, Varambally S, Barrette TR, Ghosh D, Lawrence TS, Chinnaiyan AM. Profiling of cancer cells using protein microarrays: discovery of novel radiation-regulated proteins. Cancer Res. 2001 Oct 15; 61(20):7585-93. PMID: 11606398.
      Citations: 48     Fields:    Translation:HumansCells
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