KARL-DIMITERBISSIGKARL-DIMITER BISSIG0.000000000000000.000000000000001893BISSIG, KARL-DIMITERAdjunct Associate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 86051Molecular & Cellular OncologySurgical OncologyMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorJEAN NICOLASVAUTHEYJEAN NICOLAS VAUTHEY8766VAUTHEY, JEAN NICOLASProfessorAuthorship 411021Authorship 464771Authorship 756961Center for Cell & Gene TherapyAuthorship 2810771826081744Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HE, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KDNature communicationsDevelopment and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat Commun. 2015 Jun 17; 6:7339.Nat Commun2015-06-17T00:00:002015Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model.SARAHWOODFIELDSARAH WOODFIELD10737WOODFIELD, SARAHAssistant Professor905 S Lasalle St.Durham, 77030NC9738276Solioz M, Bissig KDSchweizerische medizinische Wochenschrift[How (deficient) copper causes illness]. Schweiz Med Wochenschr. 1998 Aug 04; 128(31-32):1175-80.Schweiz Med Wochenschr1998-08-04T00:00:001998[How (deficient) copper causes illness].Authorship 2966779Authorship 299464825847065Lin F, Marcelo KL, Rajapakshe K, Coarfa C, Dean A, Wilganowski N, Robinson H, Sevick E, Bissig KD, Goldie LC, Means AR, York BHepatology (Baltimore, Md.)The camKK2/camKIV relay is an essential regulator of hepatic cancer. Hepatology. 2015 Aug; 62(2):505-20.Hepatology2015-05-09T00:00:002015The camKK2/camKIV relay is an essential regulator of hepatic cancer.10952245Bissig KD, Marti U, Solioz M, Forestier M, Zimmermann H, L?thi M, Reichen JJournal of hepatologyEpidermal growth factor is decreased in liver of rats with biliary cirrhosis but does not act as paracrine growth factor immediately after hepatectomy. J Hepatol. 2000 Aug; 33(2):275-81.J Hepatol2000-08-01T00:00:002000Epidermal growth factor is decreased in liver of rats with biliary cirrhosis but does not act as paracrine growth factor immediately after hepatectomy.26482836Shih YM, Sun CP, Chou HH, Wu TH, Chen CC, Wu PY, Enya Chen YC, Bissig KD, Tao MHScientific reportsCombinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice. Sci Rep. 2015 Oct 20; 5:15259.Sci Rep2015-10-20T00:00:002015Combinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice.11415452Bissig KD, Wunderli-Ye H, Duda PW, Solioz MThe Biochemical journalStructure-function analysis of purified Enterococcus hirae CopB copper ATPase: effect of Menkes/Wilson disease mutation homologues. Biochem J. 2001 Jul 01; 357(Pt 1):217-23.Biochem J2001-07-01T00:00:002001Structure-function analysis of purified Enterococcus hirae CopB copper ATPase: effect of Menkes/Wilson disease mutation homologues.11405236Bissig KD, La Fontaine S, Mercer JF, Solioz MBiological chemistryExpression of the human Menkes ATPase in Xenopus laevis oocytes. Biol Chem. 2001 Apr; 382(4):711-4.Biol Chem2001-04-01T00:00:002001Expression of the human Menkes ATPase in Xenopus laevis oocytes.27117591Bissig-Choisat B, Kettlun-Leyton C, Legras XD, Zorman B, Barzi M, Chen LL, Amin MD, Huang YH, Pautler RG, Hampton OA, Prakash MM, Yang D, Borowiak M, Muzny D, Doddapaneni HV, Hu J, Shi Y, Gaber MW, Hicks MJ, Thompson PA, Lu Y, Mills GB, Finegold M, Goss JA, Parsons DW, Vasudevan SA, Sumazin P, L?pez-Terrada D, Bissig KDJournal of hepatologyNovel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer. J Hepatol. 2016 08; 65(2):325-33.J Hepatol2016-04-23T00:00:002016Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer.27221221Bissig KD, Paust S, Barzi MJournal of hepatologyLiver is liver and blood is blood, and finally the twain have met. J Hepatol. 2016 08; 65(2):245-8.J Hepatol2016-05-21T00:00:002016Liver is liver and blood is blood, and finally the twain have met.74Professor10Assistant Professor48Distinguished Service Professor Emeritus21Chair14Associate Professor16Associate Professor Emeritus3Adjunct Associate Professor6Adjunct Professor11594769Multhaup G, Strausak D, Bissig KD, Solioz MBiochemical and biophysical research communicationsInteraction of the CopZ copper chaperone with the CopA copper ATPase of Enterococcus hirae assessed by surface plasmon resonance. Biochem Biophys Res Commun. 2001 Oct 19; 288(1):172-7.Biochem Biophys Res Commun2001-10-19T00:00:002001Interaction of the CopZ copper chaperone with the CopA copper ATPase of Enterococcus hirae assessed by surface plasmon resonance.11696373Bissig KD, Voegelin TC, Solioz MFEBS lettersTetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase. FEBS Lett. 2001 Nov 02; 507(3):367-70.FEBS Lett2001-11-02T00:00:002001Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase.Authorship 3213611426658683Billioud G, Kruse RL, Carrillo M, Whitten-Bauer C, Gao D, Kim A, Chen L, McCaleb ML, Crosby JR, Hamatake R, Hong Z, Garaigorta U, Swayze E, Bissig KD, Wieland SJournal of hepatologyIn vivo reduction of hepatitis B virus antigenemia and viremia by antisense oligonucleotides. J Hepatol. 2016 Apr; 64(4):781-9.J Hepatol2015-11-30T00:00:002015In vivo reduction of hepatitis B virus antigenemia and viremia by antisense oligonucleotides.Authorship 3246341Authorship 32510028Authorship 3263741427572891Pankowicz FP, Barzi M, Legras X, Hubert L, Mi T, Tomolonis JA, Ravishankar M, Sun Q, Yang D, Borowiak M, Sumazin P, Elsea SH, Bissig-Choisat B, Bissig KDNature communicationsReprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia. Nat Commun. 2016 08 30; 7:12642.Nat Commun2016-08-30T00:00:002016Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia.20179355Bissig KD, Wieland SF, Tran P, Isogawa M, Le TT, Chisari FV, Verma IMThe Journal of clinical investigationHuman liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest. 2010 Mar; 120(3):924-30.J Clin Invest2010-02-22T00:00:002010Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment.15865413Bissig KD, Honer M, Zimmermann K, Summer KH, Solioz MBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicineWhole animal copper flux assessed by positron emission tomography in the Long-Evans cinnamon rat--a feasibility study. Biometals. 2005 Feb; 18(1):83-8.Biometals2005-02-01T00:00:002005Whole animal copper flux assessed by positron emission tomography in the Long-Evans cinnamon rat--a feasibility study.21167714Ruiz S, Panopoulos AD, Herrer?as A, Bissig KD, Lutz M, Berggren WT, Verma IM, Izpisua Belmonte JCCurrent biology : CBA high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol. 2011 Jan 11; 21(1):45-52.Curr Biol2010-12-17T00:00:002010A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity.28300165Jarrett KE, Lee CM, Yeh YH, Hsu RH, Gupta R, Zhang M, Rodriguez PJ, Lee CS, Gillard BK, Bissig KD, Pownall HJ, Martin JF, Bao G, Lagor WRScientific reportsSomatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease. Sci Rep. 2017 03 16; 7:44624.Sci Rep2017-03-16T00:00:002017Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease.Authorship 8683541023746980Goldman O, Han S, Sourisseau M, Sourrisseau M, Dziedzic N, Hamou W, Corneo B, D'Souza S, Sato T, Kotton DN, Bissig KD, Kalir T, Jacobs A, Evans T, Evans MJ, Gouon-Evans VCell stem cellKDR identifies a conserved human and murine hepatic progenitor and instructs early liver development. Cell Stem Cell. 2013 Jun 06; 12(6):748-60.Cell Stem Cell2013-06-06T00:00:002013KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.Authorship 869598428487442Pankowicz FP, Jarrett KE, Lagor WR, Bissig KDGutCRISPR/Cas9: at the cutting edge of hepatology. Gut. 2017 07; 66(7):1329-1340.Gut2017-05-09T00:00:002017CRISPR/Cas9: at the cutting edge of hepatology.Authorship 870256628545044Velasquez-Mao AJ, Tsao CJM, Monroe MN, Legras X, Bissig-Choisat B, Bissig KD, Ruano R, Jacot JGPloS oneDifferentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells. PLoS One. 2017; 12(5):e0177824.PLoS One2017-05-17T00:00:002017Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells.28659616Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KDNature communicationsA novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 06 28; 8(1):39.Nat Commun2017-06-28T00:00:002017A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism.Authorship 8746491114614611Bissig KD, Zimmermann A, Bernasch D, Furrer H, Dufour JFJournal of gastroenterologyHerpes simplex virus hepatitis 4 years after liver transplantation. J Gastroenterol. 2003; 38(10):1005-8.J Gastroenterol2003-01-01T00:00:002003Herpes simplex virus hepatitis 4 years after liver transplantation.18077355Bissig KD, Le TT, Woods NB, Verma IMProceedings of the National Academy of Sciences of the United States of AmericaRepopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20507-11.Proc Natl Acad Sci U S A2007-12-11T00:00:002007Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model.29259231Woodfield SE, Shi Y, Patel RH, Jin J, Major A, Sarabia SF, Starosolski Z, Zorman B, Gupta SS, Chen Z, Ibarra AM, Bissig KD, Ghaghada KB, Sumazin P, L?pez-Terrada D, Vasudevan SAScientific reportsA Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma. Sci Rep. 2017 12 19; 7(1):17751.Sci Rep2017-12-19T00:00:002017A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma.29042563Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KDNature communicationsErratum: A novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 10 17; 8(1):984.Nat Commun2017-10-17T00:00:002017Erratum: A novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism.Authorship 8792177Authorship 88178812Authorship 88318511Authorship 8850331129018834Kruse RL, Shum T, Legras X, Barzi M, Pankowicz FP, Gottschalk S, Bissig KDMolecular therapy. Methods & clinical developmentIn Situ Liver Expression of HBsAg/CD3-Bispecific Antibodies for HBV Immunotherapy. Mol Ther Methods Clin Dev. 2017 Dec 15; 7:32-41.Mol Ther Methods Clin Dev2017-08-31T00:00:002017In Situ Liver Expression of HBsAg/CD3-Bispecific Antibodies for HBV Immunotherapy.29631939Kruse RL, Shum T, Tashiro H, Barzi M, Yi Z, Whitten-Bauer C, Legras X, Bissig-Choisat B, Garaigorta U, Gottschalk S, Bissig KDCytotherapyHBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice. Cytotherapy. 2018 05; 20(5):697-705.Cytotherapy2018-04-06T00:00:002018HBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice.true1ProfessorProfessorD008099Anatomy92029630.482513Livertrue1Associate ProfessorAssociate ProfessorD022781Anatomy1793510.827373Hepatocytes30075114Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BHAmerican journal of human geneticsArgininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension. Am J Hum Genet. 2018 08 02; 103(2):276-287.Am J Hum Genet2018-08-02T00:00:002018Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension.PAVELSUMAZINPAVEL SUMAZIN0.000000000000000.000000000000005547SUMAZIN, PAVELAssociate ProfessorAuthorship 109313D002678Living Beings911450.954497ChimeraAuthorship 92044612Authorship 9305321Authorship 93245215Authorship 937985430271949Valanejad L, Cast A, Wright M, Bissig KD, Karns R, Weirauch MT, Timchenko NCommunications biologyPARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma. Commun Biol. 2018; 1:67.Commun Biol2018-06-11T00:00:002018PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma.30093418Bissig KD, Han W, Barzi M, Kovalchuk N, Ding L, Fan X, Pankowicz FP, Zhang QY, Ding XDrug metabolism and disposition: the biological fate of chemicalsP450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity. Drug Metab Dispos. 2018 11; 46(11):1734-1744.Drug Metab Dispos2018-08-09T00:00:002018P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity.30170115Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KDGastroenterologyRapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. 2018 12; 155(6):1967-1970.e6.Gastroenterology2018-08-28T00:00:002018Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing.2021-04-30NIHBISSIG, KARL-DIMITER2016-07-01Therapeutic potential of CRISPR/Cas9 genome engineering in humanized mouse modelsR01HL1345102021-08-31NIHBISSIG, KARL-DIMITER2018-09-14Therapeutic pathway reprogramming for metabolic liver diseaseR01DK1154612018-09-12NIHBISSIG, KARL-DIMITER2017-09-13Therapeutic pathway reprogramming for metabolic liver diseaseR56DK115461Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCenter for Cell & Gene TherapyDepartment of MedicineDepartment of PediatricsDepartment of Molecular & Cellular BiologyDepartment of Molecular Virology & MicrobiologyDepartment of SurgerySurgery-Pediatric Surgery DivMedicine-Gastroenterology & HepatolMolecular & Cellular BiologyMolecular Physiology & BiophysicsMolecular Virology & MicrobiologyPediatrics-OncologyBaylor College of Medicine2.773520.00746899247research areas1.494280.033756158coauthor of29.86777.066760similar to1150selected publicationsSEANMCGUIRESEAN MCGUIRE0.000000000000000.000000000000002185MCGUIRE, SEANAssociate ProfessorCASSIUSBORDELON JRCASSIUS BORDELON JR0.000000000000000.000000000000002265BORDELON JR, CASSIUSAssociate Professor EmeritusROBERTSCHWARTZROBERT SCHWARTZ0.000000000000000.000000000000002506SCHWARTZ, ROBERTAdjunct ProfessorMING-JERTSAIMING-JER TSAI0.000000000000000.000000000000002538TSAI, MING-JERDistinguished Service Professor EmeritusRONALDDAVISRONALD DAVIS0.000000000000000.000000000000003208DAVIS, RONALDAdjunct ProfessorFASIHAKANWALFASIHA KANWAL29.70503200000000-95.407546000000004180KANWAL, FASIHAProfessorHASHEMEL-SERAGHASHEM EL-SERAG29.70560750000000-95.3846773000000068EL-SERAG, HASHEMProfessorSANJEEVVASUDEVANSANJEEV VASUDEVAN29.70731730000000-95.402264500000003804VASUDEVAN, SANJEEVAssociate ProfessorWILLIAMLAGORWILLIAM LAGOR0.000000000000000.000000000000004763LAGOR, WILLIAMProfessorD0000726691402030.826997Gene EditingD064113Physiology2103110.778874CRISPR-Cas SystemsAuthorship 127652123876405Bissig KD, Grompe MTrends in pharmacological sciencesResponse to "Can 'humanized' mice improve drug development in the 21st century?". Trends Pharmacol Sci. 2013 Aug; 34(8):425.Trends Pharmacol Sci2013-07-19T00:00:002013Response to "Can 'humanized' mice improve drug development in the 21st century?".true1Adjunct ProfessorAdjunct Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professor71Postdoc Fellows and Associates32039390Alves-Bezerra M, Furey N, Johnson CG, Bissig KDJHEP reports : innovation in hepatologyUsing CRISPR/Cas9 to model human liver disease. JHEP Rep. 2019 Nov; 1(5):392-402.JHEP Rep2019-10-25T00:00:002019Using CRISPR/Cas9 to model human liver disease.PostDoc32150344Johnson CG, Chen T, Furey N, Hemmingsen MG, Bissig KDCurrent protocols in molecular biologySomatic Liver Knockout (SLiK): A Quick and Efficient Way to Generate Liver-Specific Knockout Mice Using Multiplex CRISPR/Cas9 Gene Editing. Curr Protoc Mol Biol. 2020 Mar; 130(1):e117.Curr Protoc Mol Biol2020-03-01T00:00:002020Somatic Liver Knockout (SLiK): A Quick and Efficient Way to Generate Liver-Specific Knockout Mice Using Multiplex CRISPR/Cas9 Gene Editing.true1Associate ProfessorAssociate ProfessorAuthorship 9850364Authorship 9851184Authorship 985993531870268Akkina R, Barber DL, Bility MT, Bissig KD, Burwitz BJ, Eichelberg K, Endsley JJ, Garcia JV, Hafner R, Karakousis PC, Korba BE, Koshy R, Lambros C, Menne S, Nuermberger EL, Ploss A, Podell BK, Poluektova LY, Sanders-Beer BE, Subbian S, Wahl ACurrent HIV researchSmall Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop. Curr HIV Res. 2020; 18(1):19-28.Curr HIV Res2020-01-01T00:00:002020Small Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop.Authorship 986243732235678Minor MM, Hollinger FB, McNees AL, Jung SY, Jain A, Hyser JM, Bissig KD, Slagle BLCellsHepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex. Cells. 2020 03 30; 9(4).Cells2020-03-30T00:00:002020Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.Authorship 9928423Authorship 9929661332578942Stripecke R, M?nz C, Schuringa JJ, Bissig KD, Soper B, Meeham T, Yao LC, Di Santo JP, Brehm M, Rodriguez E, Wege AK, Bonnet D, Guionaud S, Howard KE, Kitchen S, Klein F, Saeb-Parsy K, Sam J, Sharma AD, Trumpp A, Trusolino L, Bult C, Shultz LEMBO molecular medicineInnovations, challenges, and minimal information for standardization of humanized mice. EMBO Mol Med. 2020 07 07; 12(7):e8662.EMBO Mol Med2020-06-24T00:00:002020Innovations, challenges, and minimal information for standardization of humanized mice.32601395Kinstlinger IS, Saxton SH, Calderon GA, Ruiz KV, Yalacki DR, Deme PR, Rosenkrantz JE, Louis-Rosenberg JD, Johansson F, Janson KD, Sazer DW, Panchavati SS, Bissig KD, Stevens KR, Miller JSNature biomedical engineeringGeneration of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates. Nat Biomed Eng. 2020 09; 4(9):916-932.Nat Biomed Eng2020-06-29T00:00:002020Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates.Authorship 995438532712217MacKenzie KR, Zhao M, Barzi M, Wang J, Bissig KD, Maletic-Savatic M, Jung SY, Li FEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical SciencesMetabolic profiling of norepinephrine reuptake inhibitor atomoxetine. Eur J Pharm Sci. 2020 Oct 01; 153:105488.Eur J Pharm Sci2020-07-23T00:00:002020Metabolic profiling of norepinephrine reuptake inhibitor atomoxetine.true1Postdoc Fellows and AssociatesPostdoc Fellows and AssociatesXuanQinXuan Qin16129Qin, XuanPostdoc Fellows and AssociatesAuthorship 10139861033733079Kruse RL, Barzi M, Legras X, Pankowicz FP, Furey N, Liao L, Xu J, Bissig-Choisat B, Slagle BL, Bissig KDJHEP reports : innovation in hepatologyA hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome. JHEP Rep. 2021 Apr; 3(2):100252.JHEP Rep2021-02-06T00:00:002021A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome.Authorship 10193731834036256Bissig-Choisat B, Alves-Bezerra M, Zorman B, Ochsner SA, Barzi M, Legras X, Yang D, Borowiak M, Dean AM, York RB, Galvan NTN, Goss J, Lagor WR, Moore DD, Cohen DE, McKenna NJ, Sumazin P, Bissig KDJHEP reports : innovation in hepatologyA human liver chimeric mouse model for non-alcoholic fatty liver disease. JHEP Rep. 2021 Jun; 3(3):100281.JHEP Rep2021-03-21T00:00:002021A human liver chimeric mouse model for non-alcoholic fatty liver disease.Authorship 102130713Authorship 10213711034135476Kinstlinger IS, Saxton SH, Calderon GA, Ruiz KV, Yalacki DR, Deme PR, Rosenkrantz JE, Louis-Rosenberg JD, Johansson F, Janson KD, Sazer DW, Panchavati SS, Bissig KD, Stevens KR, Miller JSNature biomedical engineeringAuthor Correction: Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates. Nat Biomed Eng. 2021 Aug; 5(8):941.Nat Biomed Eng2021-08-01T00:00:002021Author Correction: Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates.34141821De Giorgi M, Li A, Hurley A, Barzi M, Doerfler AM, Cherayil NA, Smith HE, Brown JD, Lin CY, Bissig KD, Bao G, Lagor WRMolecular therapy. Methods & clinical developmentTargeting the Apoa1 locus for liver-directed gene therapy. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:656-669.Mol Ther Methods Clin Dev2021-04-24T00:00:002021Targeting the Apoa1 locus for liver-directed gene therapy.Authorship 10342411334785568Qin X, Hakenjos JM, MacKenzie KR, Barzi M, Chavan H, Nyshadham P, Wang J, Jung SY, Guner JZ, Chen S, Guo L, Krishnamurthy P, Bissig KD, Palmer S, Matzuk MM, Li FDrug metabolism and disposition: the biological fate of chemicalsMetabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice. Drug Metab Dispos. 2022 02; 50(2):128-139.Drug Metab Dispos2021-11-16T00:00:002021Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice.Department of Integrative PhysiologyAuthorship 1054376736513193Qin X, Xie C, Hakenjos JM, MacKenzie KR, Boyd SR, Barzi M, Bissig KD, Young DW, Li FEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical SciencesThe roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice. Eur J Pharm Sci. 2023 Feb 01; 181:106358.Eur J Pharm Sci2022-12-10T00:00:002022The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice.Authorship 10681122237075130Barzi M, Johnson CG, Chen T, Rodriguiz RM, Hemmingsen M, Gonzalez TJ, Rosales A, Beasley J, Peck CK, Ma Y, Stiles AR, Wood TC, Maeso-Diaz R, Diehl AM, Young SP, Everitt JI, Wetsel WC, Lagor WR, Bissig-Choisat B, Asokan A, El-Gharbawy A, Bissig KDScience translational medicineRescue of glutaric aciduria type I in mice by liver-directed therapies. Sci Transl Med. 2023 04 19; 15(692):eadf4086.Sci Transl Med2023-04-19T00:00:002023Rescue of glutaric aciduria type I in mice by liver-directed therapies.true1Adjunct ProfessorAdjunct Professortrue1Associate Professor EmeritusAssociate Professor Emeritustrue1ProfessorProfessor37546995De Giorgi M, Park SH, Castoreno A, Cao M, Hurley A, Saxena L, Chuecos MA, Walkey CJ, Doerfler AM, Furgurson MN, Ljungberg MC, Patel KR, Hyde S, Chickering T, Lefebvre S, Wassarman K, Miller P, Qin J, Schlegel MK, Zlatev I, Li RG, Kim J, Martin JF, Bissig KD, Jadhav V, Bao G, Lagor WRbioRxiv : the preprint server for biologyIn vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene. bioRxiv. 2023 Jul 29.bioRxiv2023-07-29T00:00:002023In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.true1Adjunct Associate ProfessorAdjunct Associate Professor2Adjunct Associate ProfessorAdjunct Associate Professor3Adjunct Associate ProfessorAdjunct Associate ProfessorAuthorship 108191824Authorship 10827611137890720Padilla J, Osman NM, Bissig-Choisat B, Grimm SL, Qin X, Major AM, Yang L, Lopez-Terrada D, Coarfa C, Li F, Bissig KD, Moore DD, Fu LJournal of hepatologyCircadian dysfunction induces NAFLD-related human liver cancer in a mouse model. J Hepatol. 2024 Feb; 80(2):282-292.J Hepatol2023-10-27T00:00:002023Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model.Authorship 10870322138242326Espinoza AF, Patel RH, Patel KR, Badachhape AA, Whitlock R, Srivastava RK, Govindu SR, Duong A, Kona A, Kureti P, Armbruster B, Kats D, Srinivasan RR, Dobrolecki LE, Yu X, Najaf Panah MJ, Zorman B, Sarabia SF, Urbicain M, Major A, Bissig KD, Keller C, Lewis MT, Heczey A, Sumazin P, L?pez-Terrada DH, Woodfield SE, Vasudevan SAJournal of hepatologyA novel treatment strategy utilizing panobinostat for high-risk and treatment-refractory hepatoblastoma. J Hepatol. 2024 Apr; 80(4):610-621.J Hepatol2024-01-17T00:00:002024A novel treatment strategy utilizing panobinostat for high-risk and treatment-refractory hepatoblastoma.Authorship 10902211838438373Barzi M, Chen T, Gonzalez TJ, Pankowicz FP, Oh SH, Streff HL, Rosales A, Ma Y, Collias S, Woodfield SE, Diehl AM, Vasudevan SA, Galvan TN, Goss J, Gersbach CA, Bissig-Choisat B, Asokan A, Bissig KDNature communicationsA humanized mouse model for adeno-associated viral gene therapy. Nat Commun. 2024 Mar 04; 15(1):1955.Nat Commun2024-03-04T00:00:002024A humanized mouse model for adeno-associated viral gene therapy.true1Distinguished Service Professor EmeritusDistinguished Service Professor Emeritustrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 267501Authorship 285951Authorship 391831Authorship 6042811Authorship 45631Authorship 652891Authorship 70283