CHOELKIMCHOEL KIM0.000000000000000.000000000000001534KIM, CHOELAssociate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonMolecular & Cellular OncologyMD AndersonKEVINMACKENZIEKEVIN MACKENZIE11004MACKENZIE, KEVINAssociate ProfessorOne Baylor PlazaHouston, 77030TX74Professor10Assistant Professor27Clinical Assistant Professor21Chair14Associate Professor78Professor Emeritus6Adjunct ProfessorJOHNTAINERJOHN TAINER11926TAINER, JOHNProfessor27914169Campbell JC, VanSchouwen B, Lorenz R, Sankaran B, Herberg FW, Melacini G, Kim CFEBS lettersCrystal structure of cGMP-dependent protein kinase I? cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation. FEBS Lett. 2017 Jan; 591(1):221-230.FEBS Lett2016-12-23T00:00:002016Crystal structure of cGMP-dependent protein kinase I? cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation.21526164Kim JJ, Casteel DE, Huang G, Kwon TH, Ren RK, Zwart P, Headd JJ, Brown NG, Chow DC, Palzkill T, Kim CPloS oneCo-crystal structures of PKG I? (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. PLoS One. 2011 Apr 19; 6(4):e18413.PLoS One2011-04-19T00:00:002011Co-crystal structures of PKG I? (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding.true1ProfessorProfessorD017869Chemicals & Drugs14240.974848Cyclic GMP-Dependent Protein KinasesRajeshSharmaRajesh Sharma14465Sharma, RajeshPostdoc Fellows and AssociatesD018360Procedures1726260.854494Crystallography, X-Ray26769964Campbell JC, Kim JJ, Li KY, Huang GY, Reger AS, Matsuda S, Sankaran B, Link TM, Yuasa K, Ladbury JE, Casteel DE, Kim CThe Journal of biological chemistryStructural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. J Biol Chem. 2016 Mar 11; 291(11):5623-5633.J Biol Chem2016-01-14T00:00:002016Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.D006152Chemicals & Drugs691160.949413Cyclic GMPDepartment of Pathology & ImmunologyDepartment of RadiologyDepartment of SurgeryRadiologySurgery-Cardio/Thoracic SurgeryPathologyBaylor College of MedicineJAMESCROWEJAMES CROWE0.000000000000000.000000000000001560CROWE, JAMESAssociate Professor3.721960.00439489159research areas2.135380.029861516coauthor of29.80412.5965560similar to1123selected publicationsMARTINMATZUKMARTIN MATZUK0.000000000000000.000000000000001976MATZUK, MARTINProfessorBENIGNOVALDEZBENIGNO VALDEZ0.000000000000000.000000000000003269VALDEZ, BENIGNOAdjunct ProfessorJOSEPHCOSELLIJOSEPH COSELLI29.70508570000000-95.401808700000002292COSELLI, JOSEPHProfessorGERALDBUSCHGERALD BUSCH0.000000000000000.000000000000002917BUSCH, GERALDClinical Assistant ProfessorSUSANBERGETSUSAN BERGET0.000000000000000.000000000000003084BERGET, SUSANProfessor EmeritusTIMOTHYPALZKILLTIMOTHY PALZKILL0.000000000000000.000000000000003364PALZKILL, TIMOTHYChairPETERDAVIESPETER DAVIES0.000000000000000.000000000000004506DAVIES, PETERAdjunct Professor31003488Sutton MN, Huang GY, Liang X, Sharma R, Reger AS, Mao W, Pang L, Rask PJ, Lee K, Gray JP, Hurwitz AM, Palzkill T, Millward SW, Kim C, Lu Z, Bast RCCancersDIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1. Cancers (Basel). 2019 Apr 18; 11(4).Cancers (Basel)2019-04-18T00:00:002019DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1.D062965Chemicals & Drugs7150.974271Cyclic GMP-Dependent Protein Kinase Type ID062967Chemicals & Drugs570.992099Cyclic GMP-Dependent Protein Kinase Type II23910461Guo DC, Regalado E, Casteel DE, Santos-Cortez RL, Gong L, Kim JJ, Dyack S, Horne SG, Chang G, Jondeau G, Boileau C, Coselli JS, Li Z, Leal SM, Shendure J, Rieder MJ, Bamshad MJ, Nickerson DA, GenTAC Registry Consortium, National Heart, Lung, and Blood Institute Grand Opportunity Exome Sequencing Project, Kim C, Milewicz DMAmerican journal of human geneticsRecurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. Am J Hum Genet. 2013 Aug 08; 93(2):398-404.Am J Hum Genet2013-08-01T00:00:002013Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections.2021-06-30NIHKIM, CHOEL WOONG2010-07-01Activation and Regulation Mechanisms of cGMP-dependent Protein Kinase I and IIR01GM0901612014-12-30NIHKIM, CHOEL WOONG2012-07-17TARGETING CGMP KINASES TO DEVELOP NEW THERAPEUTICS FOR HYPERTENSIVE DISEASESR21HL111953Principal InvestigatorPrincipal InvestigatorAuthorship 9755978Authorship 9755981Authorship 97560414Authorship 9756057Authorship 9756099Authorship 9756115Authorship 9756185Authorship 9756217Authorship 97562311Authorship 97581314Authorship 97581421Authorship 9758225Authorship 9758256Authorship 97583117Authorship 9758347Authorship 9758366Authorship 9759511Authorship 9760151217889648Kim C, Cheng CY, Saldanha SA, Taylor SSCellPKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell. 2007 Sep 21; 130(6):1032-43.Cell2007-09-21T00:00:002007PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation.26132214Qin L, Reger AS, Guo E, Yang MP, Zwart P, Casteel DE, Kim CBiochemistryStructures of cGMP-Dependent Protein Kinase (PKG) Ia Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability. Biochemistry. 2015 Jul 28; 54(29):4419-22.Biochemistry2015-07-15T00:00:002015Structures of cGMP-Dependent Protein Kinase (PKG) Ia Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability.25070890Reger AS, Yang MP, Koide-Yoshida S, Guo E, Mehta S, Yuasa K, Liu A, Casteel DE, Kim CThe Journal of biological chemistryCrystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions. J Biol Chem. 2014 Sep 12; 289(37):25393-403.J Biol Chem2014-07-28T00:00:002014Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions.27761512Campbell JC, Tischer A, Machha V, Moon-Tasson L, Sankaran B, Kim C, Auton MData in briefData on the purification and crystallization of the loss-of-function von Willebrand disease variant (p.Gly1324Ser) of the von Willebrand factor A1 domain. Data Brief. 2016 Jun; 7:1700-1706.Data Brief2016-05-10T00:00:002016Data on the purification and crystallization of the loss-of-function von Willebrand disease variant (p.Gly1324Ser) of the von Willebrand factor A1 domain.20826808Casteel DE, Smith-Nguyen EV, Sankaran B, Roh SH, Pilz RB, Kim CThe Journal of biological chemistryA crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring. J Biol Chem. 2010 Oct 22; 285(43):32684-32688.J Biol Chem2010-09-08T00:00:002010A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring.31948450Kim C, Sharma R, Casteel DEJournal of translational medicineCorrection to: Crystal structure of PKG I? holoenzyme reveals a trans-inhibiting dimer assembly. J Transl Med. 2020 Jan 16; 18(1):27.J Transl Med2020-01-16T00:00:002020Correction to: Crystal structure of PKG I? holoenzyme reveals a trans-inhibiting dimer assembly.22020785Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K, Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, Schwede TProteinsTarget highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins. 2011; 79 Suppl 10:6-20.Proteins2011-10-21T00:00:002011Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction.29769318Qin L, Sankaran B, Aminzai S, Casteel DE, Kim CThe Journal of biological chemistryStructural basis for selective inhibition of human PKG Ia by the balanol-like compound N46. J Biol Chem. 2018 07 13; 293(28):10985-10992.J Biol Chem2018-05-16T00:00:002018Structural basis for selective inhibition of human PKG Ia by the balanol-like compound N46.27697864Cho KJ, Casteel DE, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C, Capon RJ, Lacey E, Cunha SR, Gorfe AA, Hancock JFMolecular and cellular biologyAMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2. Mol Cell Biol. 2016 12 15; 36(24):3086-3099.Mol Cell Biol2016-11-28T00:00:002016AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2.27066748Kim JJ, Lorenz R, Arold ST, Reger AS, Sankaran B, Casteel DE, Herberg FW, Kim CStructure (London, England : 1993)Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure. 2016 05 03; 24(5):710-720.Structure2016-04-07T00:00:002016Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.21643460Lee JH, Li S, Liu T, Hsu S, Kim C, Woods VL, Casteel DEInternational journal of mass spectrometryThe amino terminus of cGMP-dependent protein kinase I? increases the dynamics of the protein's cGMP-binding pockets. Int J Mass Spectrom. 2011 Apr 30; 302(1-3):44-52.Int J Mass Spectrom2011-04-30T00:00:002011The amino terminus of cGMP-dependent protein kinase I? increases the dynamics of the protein's cGMP-binding pockets.71Postdoc Fellows and AssociatesPostDoctrue1Associate ProfessorAssociate ProfessorAuthorship 991306632506052Chan MH, Aminzai S, Hu T, Taran A, Li S, Kim C, Pilz RB, Casteel DEThe Journal of biological chemistryA substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP. J Biol Chem. 2020 07 24; 295(30):10394-10405.J Biol Chem2020-06-05T00:00:002020A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP.Authorship 1006296133271627Kim C, Sharma RProtein science : a publication of the Protein SocietyCyclic nucleotide selectivity of protein kinase G isozymes. Protein Sci. 2021 02; 30(2):316-327.Protein Sci2020-12-10T00:00:002020Cyclic nucleotide selectivity of protein kinase G isozymes.Authorship 10124251833637650Yu Z, Ku AF, Anglin JL, Sharma R, Ucisik MN, Faver JC, Li F, Nyshadham P, Simmons N, Sharma KL, Nagarajan S, Riehle K, Kaur G, Sankaran B, Storl-Desmond M, Palmer SS, Young DW, Kim C, Matzuk MMProceedings of the National Academy of Sciences of the United States of AmericaDiscovery and characterization of bromodomain 2-specific inhibitors of BRDT. Proc Natl Acad Sci U S A. 2021 03 02; 118(9).Proc Natl Acad Sci U S A2021-03-02T00:00:002021Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.MATTHEWYANGMATTHEW YANG17048YANG, MATTHEWAuthorship 10302011134552088Sharma R, Choi KJ, Quan MD, Sharma S, Sankaran B, Park H, LaGrone A, Kim JJ, MacKenzie KR, Ferreon ACM, Kim C, Ferreon JCNature communicationsLiquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Nat Commun. 2021 09 22; 12(1):5579.Nat Commun2021-09-22T00:00:002021Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization.24291220Campeau PM, Kasperaviciute D, Lu JT, Burrage LC, Kim C, Hori M, Powell BR, Stewart F, F?lix TM, van den Ende J, Wisniewska M, Kayserili H, Rump P, Nampoothiri S, Aftimos S, Mey A, Nair LD, Begleiter ML, De Bie I, Meenakshi G, Murray ML, Repetto GM, Golabi M, Blair E, Male A, Giuliano F, Kariminejad A, Newman WG, Bhaskar SS, Dickerson JE, Kerr B, Banka S, Giltay JC, Wieczorek D, Tostevin A, Wiszniewska J, Cheung SW, Hennekam RC, Gibbs RA, Lee BH, Sisodiya SMThe Lancet. NeurologyThe genetic basis of DOORS syndrome: an exome-sequencing study. Lancet Neurol. 2014 Jan; 13(1):44-58.Lancet Neurol2013-11-29T00:00:002013The genetic basis of DOORS syndrome: an exome-sequencing study.Authorship 10600601335929723Sharma R, Kim JJ, Qin L, Henning P, Akimoto M, VanSchouwen B, Kaur G, Sankaran B, MacKenzie KR, Melacini G, Casteel DE, Herberg FW, Kim CeLifeAn auto-inhibited state of protein kinase G and implications for selective activation. Elife. 2022 08 05; 11.Elife2022-08-05T00:00:002022An auto-inhibited state of protein kinase G and implications for selective activation.true1Professor EmeritusProfessor Emeritustrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1ChairChairtrue1ProfessorProfessorDepartment of Biochemistry and Molecular PharmacologyBiochemistry & Mol Pharmacologytrue1Associate ProfessorAssociate Professortrue1Adjunct ProfessorAdjunct Professortrue1Clinical Assistant ProfessorClinical Assistant Professortrue1Adjunct ProfessorAdjunct Professortrue1Postdoc Fellows and AssociatesPostdoc Fellows and Associatestrue1ProfessorProfessor24239458Huang GY, Kim JJ, Reger AS, Lorenz R, Moon EW, Zhao C, Casteel DE, Bertinetti D, Vanschouwen B, Selvaratnam R, Pflugrath JW, Sankaran B, Melacini G, Herberg FW, Kim CStructure (London, England : 1993)Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I. Structure. 2014 Jan 07; 22(1):116-24.Structure2013-11-14T00:00:002013Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I.JOSEPHINEFERREONJOSEPHINE FERREON7853FERREON, JOSEPHINEAssociate Professor