BENJAMINDENEENBENJAMIN DENEEN0.000000000000000.000000000000001530DENEEN, BENJAMINProfessorprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:orcidIdORCID idvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 867211Authorship 1015448Authorship 1079182Authorship 1114022Authorship 160471Authorship 161981725754822Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SP, Deneen BNeuronDaam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Neuron. 2015 Mar 18; 85(6):1227-43.Neuron2015-03-05T00:00:002015Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS.Neuro-OncologyMD AndersonAMY BHEIMBERGERAMY B HEIMBERGER9035HEIMBERGER, AMY BProfessorJOSEPHMCCARTYJOSEPH MCCARTY9289MCCARTY, JOSEPHAssociate ProfessorJOHN FREDERICKDE GROOTJOHN FREDERICK DE GROOT9019DE GROOT, JOHN FREDERICKProfessorAuthorship 506601Authorship 586857Authorship 815495Authorship 849563Authorship 984357Center for Cell & Gene TherapyOne Baylor PlazaHouston, 77030TX10353897Sekelsky JJ, McKim KS, Messina L, French RL, Hurley WD, Arbel T, Chin GM, Deneen B, Force SJ, Hari KL, Jang JK, Lauren?on AC, Madden LD, Matthies HJ, Milliken DB, Page SL, Ring AD, Wayson SM, Zimmerman CC, Hawley RSGeneticsIdentification of novel Drosophila meiotic genes recovered in a P-element screen. Genetics. 1999 Jun; 152(2):529-42.Genetics1999-06-01T00:00:001999Identification of novel Drosophila meiotic genes recovered in a P-element screen.Authorship 2913078Authorship 3029699Authorship 303042225224546Garcia I, Bhullar PK, Tepe B, Ortiz-Guzman J, Huang L, Herman AM, Chaboub L, Deneen B, Justice NJ, Arenkiel BRBrain structure & functionLocal corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb. Brain Struct Funct. 2016 Jan; 221(1):1-20.Brain Struct Funct2014-09-16T00:00:002014Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb.25946682Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SP, Mohila C, Deneen BGliaApcdd1 stimulates oligodendrocyte differentiation after white matter injury. Glia. 2015 Oct; 63(10):1840-9.Glia2015-05-06T00:00:002015Apcdd1 stimulates oligodendrocyte differentiation after white matter injury.25963996Molofsky AV, Deneen BGliaAstrocyte development: A Guide for the Perplexed. Glia. 2015 Aug; 63(8):1320-9.Glia2015-05-12T00:00:002015Astrocyte development: A Guide for the Perplexed.10924472Page SL, McKim KS, Deneen B, Van Hook TL, Hawley RSGeneticsGenetic studies of mei-P26 reveal a link between the processes that control germ cell proliferation in both sexes and those that control meiotic exchange in Drosophila. Genetics. 2000 Aug; 155(4):1757-72.Genetics2000-08-01T00:00:002000Genetic studies of mei-P26 reveal a link between the processes that control germ cell proliferation in both sexes and those that control meiotic exchange in Drosophila.74Professor10Assistant Professor54Instructor14Associate Professor16Associate Professor Emeritus6Adjunct ProfessorPediatrics-Neur NRI12874036Deneen B, Hamidi H, Denny CTCancer researchFunctional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res. 2003 Jul 15; 63(14):4268-74.Cancer Res2003-07-15T00:00:002003Functional analysis of the EWS/ETS target gene uridine phosphorylase.12748291Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CTMolecular and cellular biologyPIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 2003 Jun; 23(11):3897-908.Mol Cell Biol2003-06-01T00:00:002003PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins.18455991Hochstim C, Deneen B, Lukaszewicz A, Zhou Q, Anderson DJCellIdentification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code. Cell. 2008 May 02; 133(3):510-22.Cell2008-05-02T00:00:002008Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code.53Graduate Student20150379Song HR, Gonzalez-Gomez I, Suh GS, Commins DL, Sposto R, Gilles FH, Deneen B, Erdreich-Epstein ANeuro-oncologyNuclear factor IA is expressed in astrocytomas and is associated with improved survival. Neuro Oncol. 2010 Feb; 12(2):122-32.Neuro Oncol2010-01-25T00:00:002010Nuclear factor IA is expressed in astrocytomas and is associated with improved survival.22500632Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen BNeuronSox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 Apr 12; 74(1):79-94.Neuron2012-04-12T00:00:002012Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis.23147551Chaboub LS, Deneen BDevelopmental neuroscienceDevelopmental origins of astrocyte heterogeneity: the final frontier of CNS development. Dev Neurosci. 2012; 34(5):379-88.Dev Neurosci2012-11-09T00:00:002012Developmental origins of astrocyte heterogeneity: the final frontier of CNS development.DebosmitaSardarDebosmita Sardar12544Sardar, DebosmitaPostdoc Fellows and AssociatesAuthorship 6529521127881777Chaboub LS, Manalo JM, Lee HK, Glasgow SM, Chen F, Kawasaki Y, Akiyama T, Kuo CT, Creighton CJ, Mohila CA, Deneen BThe Journal of neuroscience : the official journal of the Society for NeuroscienceTemporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. J Neurosci. 2016 11 23; 36(47):11904-11917.J Neurosci2016-11-23T00:00:002016Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury.28103473Glasgow SM, Deneen BNeuronlnc'edin to Myelin. Neuron. 2017 Jan 18; 93(2):252-254.Neuron2017-01-18T00:00:002017lnc'edin to Myelin.Authorship 6783272Authorship 7021851728166219John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen BNature neuroscienceIdentification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar; 20(3):396-405.Nat Neurosci2017-02-06T00:00:002017Identification of diverse astrocyte populations and their malignant analogs.JASONHUSEJASON HUSE12747HUSE, JASONAssociate Professor22807310Fancy SP, Glasgow SM, Finley M, Rowitch DH, Deneen BAnnals of neurologyEvidence that nuclear factor IA inhibits repair after white matter injury. Ann Neurol. 2012 Aug; 72(2):224-33.Ann Neurol2012-07-17T00:00:002012Evidence that nuclear factor IA inhibits repair after white matter injury.11553628Welford SM, Hebert SP, Deneen B, Arvand A, Denny CTThe Journal of biological chemistryDNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis. J Biol Chem. 2001 Nov 09; 276(45):41977-84.J Biol Chem2001-09-11T00:00:002001DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis.11709708Deneen B, Denny CTOncogeneLoss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation. Oncogene. 2001 Oct 11; 20(46):6731-41.Oncogene2001-10-11T00:00:002001Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation.Authorship 876587228771716Wang CY, Deneen B, Tzeng SFJournal of neurochemistryMicroRNA-212 inhibits oligodendrocytes during maturation by down-regulation of differentiation-associated gene expression. J Neurochem. 2017 10; 143(1):112-125.J Neurochem2017-09-14T00:00:002017MicroRNA-212 inhibits oligodendrocytes during maturation by down-regulation of differentiation-associated gene expression.16432183Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJProceedings of the National Academy of Sciences of the United States of AmericaOlig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1551-6.Proc Natl Acad Sci U S A2006-01-23T00:00:002006Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo.17178400Deneen B, Ho R, Lukaszewicz A, Hochstim CJ, Gronostajski RM, Anderson DJNeuronThe transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron. 2006 Dec 21; 52(6):953-68.Neuron2006-12-21T00:00:002006The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord.19217426Namihira M, Kohyama J, Semi K, Sanosaka T, Deneen B, Taga T, Nakashima KDevelopmental cellCommitted neuronal precursors confer astrocytic potential on residual neural precursor cells. Dev Cell. 2009 Feb; 16(2):245-55.Dev Cell2009-02-01T00:00:002009Committed neuronal precursors confer astrocytic potential on residual neural precursor cells.22227309Lee HK, Deneen BDevelopmental cellDaam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord. Dev Cell. 2012 Jan 17; 22(1):183-96.Dev Cell2012-01-05T00:00:002012Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord.22549954Molofsky AV, Krencik R, Krenick R, Ullian EM, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DHGenes & developmentAstrocytes and disease: a neurodevelopmental perspective. Genes Dev. 2012 May 01; 26(9):891-907.Genes Dev2012-05-01T00:00:002012Astrocytes and disease: a neurodevelopmental perspective.Authorship 87918812Authorship 88015111Authorship 88199012Authorship 88277515Authorship 8831154Authorship 8849001729053101Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK, Deneen BeLifeDaam2 driven degradation of VHL promotes gliomagenesis. Elife. 2017 10 20; 6.Elife2017-10-20T00:00:002017Daam2 driven degradation of VHL promotes gliomagenesis.29183891Byrd TT, Fousek K, Pignata A, Szot C, Samaha H, Seaman S, Dobrolecki L, Salsman VS, Oo HZ, Bielamowicz K, Landi D, Rainusso N, Hicks J, Powell S, Baker ML, Wels WS, Koch J, Sorensen PH, Deneen B, Ellis MJ, Lewis MT, Hegde M, Fletcher BS, St Croix B, Ahmed NCancer researchTEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. Cancer Res. 2018 01 15; 78(2):489-500.Cancer Res2017-11-28T00:00:002017TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer.29535300Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang FF, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JTNature communicationsAtrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun. 2018 03 13; 9(1):1057.Nat Commun2018-03-13T00:00:002018Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling.28892058Glasgow SM, Carlson JC, Zhu W, Chaboub LS, Kang P, Lee HK, Clovis YM, Lozzi BE, McEvilly RJ, Rosenfeld MG, Creighton CJ, Lee SK, Mohila CA, Deneen BNature neuroscienceGlia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nat Neurosci. 2017 Nov; 20(11):1520-1528.Nat Neurosci2017-09-11T00:00:002017Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis.29440175Chen F, Zhang Y, Gibbons DL, Deneen B, Kwiatkowski DJ, Ittmann M, Creighton CJClinical cancer research : an official journal of the American Association for Cancer ResearchPan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases. Clin Cancer Res. 2018 05 01; 24(9):2182-2193.Clin Cancer Res2018-02-09T00:00:002018Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases.29458417Kfoury N, Sun T, Yu K, Rockwell N, Tinkum KL, Qi Z, Warrington NM, McDonald P, Roy A, Weir SJ, Mohila CA, Deneen B, Rubin JBActa neuropathologica communicationsCooperative p16 and p21 action protects female astrocytes from transformation. Acta Neuropathol Commun. 2018 02 20; 6(1):12.Acta Neuropathol Commun2018-02-20T00:00:002018Cooperative p16 and p21 action protects female astrocytes from transformation.JUNSUNGWOOJUNSUNG WOO14050WOO, JUNSUNGInstructorD001253Anatomy1603700.760281AstrocytesD002490Anatomy2824350.803915Central Nervous SystemD001932Disorders88848480.292739Brain Neoplasmstrue1Postdoc Fellows and AssociatesPostdoc Fellows and AssociatesD005910Disorders38619630.43438GliomaAuthorship 9246293Authorship 9358401129777182Laug D, Glasgow SM, Deneen BNature reviews. NeuroscienceA glial blueprint for gliomagenesis. Nat Rev Neurosci. 2018 07; 19(7):393-403.Nat Rev Neurosci2018-07-01T00:00:002018A glial blueprint for gliomagenesis.30590051Scavuzzo MA, Chmielowiec J, Yang D, Wamble K, Chaboub LS, Duraine L, Tepe B, Glasgow SM, Arenkiel BR, Brou C, Deneen B, Borowiak MCell reportsPancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA. Cell Rep. 2018 12 26; 25(13):3811-3827.e7.Cell Rep2018-12-26T00:00:002018Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA.2021-03-31NIHZHENG, HUI2016-08-15Decoding the role of diverse astrocyte populations in aging and ADRF1AG0541112017-01-31NIHDENEEN, BENJAMIN2015-02-01The nature of astrocyte heterogeneity in RTTR21NS0893662023-11-30NIHDENEEN, BENJAMIN ;NOEBELS, JEFFREY2017-12-15MOLECULAR DISSECTION OF SEIZURE MICROENVIRONMENT IN MALIGNANT GLIOMAR01CA2233882007-03-31NIHDENEEN, BENJAMIN2006-04-01The role of NFI genes in glial cell fate determinationF32NS0486662022-07-31NIHMILLS, GORDON B.2017-09-06Integrative bioinformatics and functional characterization of oncogenic driver aberrations in cancerU01CA2178422024-06-30NIHDENEEN, BENJAMIN2010-09-01Transcriptional Control of Gliogenesis in the CNSR01NS0711532024-04-30NIHBONDY, MELISSA L.2018-05-08Discovery, Biology and Risk of Inherited Variants in GliomaR01CA2171052018-06-30NIHDENEEN, BENJAMIN2016-07-15Developing Novel Therapeutic Approaches for White Matter Injury in the Neonatal BrainR21NS0931452022-01-31NIHDENEEN, BENJAMIN2017-02-01MOLECULAR AND CELLULAR CONTROL OF INJURY-INDUCED ASTROGENESISR01NS096096Principal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorD051839Chemicals & Drugs40740.944843NFI Transcription FactorsNeurosurgeryPathologyCenter for Cell & Gene TherapyDepartment of NeuroscienceDepartment of PediatricsDepartment of NeurosurgeryNeuroscienceNeurosurgeryBaylor College of MedicineFREDERICKLANGFREDERICK LANG29.70706480000000-95.397162400000001037LANG, FREDERICKAdjunct Professor11.53170.00465783406research areas5.088360.040302462coauthor of93.422422.028559similar to1190selected publicationsBRUCEEHNIBRUCE EHNI0.000000000000000.000000000000002542EHNI, BRUCEAssociate Professor EmeritusASHWINVISWANATHANASHWIN VISWANATHAN0.000000000000000.0000000000000090VISWANATHAN, ASHWINProfessorIANMCCUTCHEONIAN MCCUTCHEON0.000000000000000.000000000000003751MCCUTCHEON, IANAdjunct ProfessorFRANCODEMONTEFRANCO DEMONTE0.000000000000000.000000000000003748DEMONTE, FRANCOAdjunct ProfessorAuthorship 944687430957015Cuevas-Diaz Duran R, Wang CY, Zheng H, Deneen B, Wu JQeNeuroBrain Region-Specific Gene Signatures Revealed by Distinct Astrocyte Subpopulations Unveil Links to Glioma and Neurodegenerative Diseases. eNeuro. 2019 Mar-Apr; 6(2).eNeuro2019-04-02T00:00:002019Brain Region-Specific Gene Signatures Revealed by Distinct Astrocyte Subpopulations Unveil Links to Glioma and Neurodegenerative Diseases.Authorship 12750411Authorship 1277261123840004Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MCGliaExpression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia. 2013 Sep; 61(9):1518-32.Glia2013-07-10T00:00:002013Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions.23946414Glasgow SM, Laug D, Brawley VS, Zhang Z, Corder A, Yin Z, Wong ST, Li XN, Foster AE, Ahmed N, Deneen BThe Journal of neuroscience : the official journal of the Society for NeuroscienceThe miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS. J Neurosci. 2013 Aug 14; 33(33):13560-8.J Neurosci2013-08-14T00:00:002013The miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS.Authorship 948939231184779Wang CY, Deneen B, Tzeng SFGliaBRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte differentiation by dynamically regulating lysine 63-linked ubiquitination. Glia. 2019 09; 67(9):1775-1792.Glia2019-06-11T00:00:002019BRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte differentiation by dynamically regulating lysine 63-linked ubiquitination.Authorship 951850231283899Khakh BS, Deneen BAnnual review of neuroscienceThe Emerging Nature of Astrocyte Diversity. Annu Rev Neurosci. 2019 07 08; 42:187-207.Annu Rev Neurosci2019-07-08T00:00:002019The Emerging Nature of Astrocyte Diversity.Authorship 9551781331498149Laug D, Huang TW, Huerta NAB, Huang AY, Sardar D, Ortiz-Guzman J, Carlson JC, Arenkiel BR, Kuo CT, Mohila CA, Glasgow SM, Lee HK, Deneen BThe Journal of clinical investigationNuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury. J Clin Invest. 2019 10 01; 129(10):4408-4418.J Clin Invest2019-10-01T00:00:002019Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury.2ProfessorProfessor3ProfessorProfessortrue1ProfessorProfessorGenetics & GenomicsAuthorship 9766891731996845Yu K, Lin CJ, Hatcher A, Lozzi B, Kong K, Huang-Hobbs E, Cheng YT, Beechar VB, Zhu W, Zhang Y, Chen F, Mills GB, Mohila CA, Creighton CJ, Noebels JL, Scott KL, Deneen BNaturePIK3CA variants selectively initiate brain hyperactivity during gliomagenesis. Nature. 2020 02; 578(7793):166-171.Nature2020-01-29T00:00:002020PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.71Postdoc Fellows and AssociatesPostDocHYUN-KYOUNGLEEPrIl727eL4fVRIzgrn7GPw==HYUN-KYOUNG LEE0.000000000000000.000000000000006067LEE, HYUN-KYOUNG0000-0001-5793-4398Associate ProfessorKWANHAYUKWANHA YU0.000000000000000.000000000000006611YU, KWANHAAssistant Professortrue1Assistant ProfessorAssistant ProfessorAuthorship 978985532153350Lozzi B, Huang TW, Sardar D, Huang AY, Deneen BFrontiers in neuroscienceRegionally Distinct Astrocytes Display Unique Transcription Factor Profiles in the Adult Brain. Front Neurosci. 2020; 14:61.Front Neurosci2020-02-21T00:00:002020Regionally Distinct Astrocytes Display Unique Transcription Factor Profiles in the Adult Brain.true1Adjunct ProfessorAdjunct Professortrue1Adjunct ProfessorAdjunct Professortrue1Adjunct ProfessorAdjunct ProfessorAuthorship 9865285Authorship 986757332250339Hatcher A, Yu K, Meyer J, Aiba I, Deneen B, Noebels JLThe Journal of clinical investigationPathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model. J Clin Invest. 2020 05 01; 130(5):2286-2300.J Clin Invest2020-05-01T00:00:002020Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model.32269761Akdemir ES, Huang AY, Deneen BF1000ResearchAstrocytogenesis: where, when, and how. F1000Res. 2020; 9.F1000Res2020-04-02T00:00:002020Astrocytogenesis: where, when, and how.Authorship 9876004Authorship 9878581032320644Huang AY, Woo J, Sardar D, Lozzi B, Bosquez Huerta NA, Lin CJ, Felice D, Jain A, Paulucci-Holthauzen A, Deneen BNeuronRegion-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities. Neuron. 2020 06 17; 106(6):992-1008.e9.Neuron2020-04-21T00:00:002020Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities.32302564Monje M, Borniger JC, D'Silva NJ, Deneen B, Dirks PB, Fattahi F, Frenette PS, Garzia L, Gutmann DH, Hanahan D, Hervey-Jumper SL, Hondermarck H, Hurov JB, Kepecs A, Knox SM, Lloyd AC, Magnon C, Saloman JL, Segal RA, Sloan EK, Sun X, Taylor MD, Tracey KJ, Trotman LC, Tuveson DA, Wang TC, White RA, Winkler FCellRoadmap for the Emerging Field of Cancer Neuroscience. Cell. 2020 04 16; 181(2):219-222.Cell2020-04-16T00:00:002020Roadmap for the Emerging Field of Cancer Neuroscience.Authorship 989721532426930Ung K, Tepe B, Pekarek B, Arenkiel BR, Deneen BJournal of neuroscience researchParallel astrocyte calcium signaling modulates olfactory bulb responses. J Neurosci Res. 2020 08; 98(8):1605-1618.J Neurosci Res2020-05-19T00:00:002020Parallel astrocyte calcium signaling modulates olfactory bulb responses.true1Graduate StudentGraduate StudentBrittneyLozziBrittney Lozzi15882Lozzi, BrittneyGraduate Studenttrue1ProfessorProfessorAuthorship 10078341233367832Carlson JC, Cantu Gutierrez M, Lozzi B, Huang-Hobbs E, Turner WD, Tepe B, Zhang Y, Herman AM, Rao G, Creighton CJ, Wythe JD, Deneen BNeuro-oncologyIdentification of diverse tumor endothelial cell populations in malignant glioma. Neuro Oncol. 2021 06 01; 23(6):932-944.Neuro Oncol2021-06-01T00:00:002021Identification of diverse tumor endothelial cell populations in malignant glioma.Authorship 10105221233535036Wei H, Wu X, You Y, Duran RC, Zheng Y, Narayanan KL, Hai B, Li X, Tallapragada N, Prajapati TJ, Kim DH, Deneen B, Cao QL, Wu JQCell reportsSystematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis. Cell Rep. 2021 02 02; 34(5):108721.Cell Rep2021-02-02T00:00:002021Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis.Authorship 10116251533589835Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinh?user C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, D?az-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, G?tz M, Guti?rrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, P?rez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky ANature neuroscienceReactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 03; 24(3):312-325.Nat Neurosci2021-02-15T00:00:002021Reactive astrocyte nomenclature, definitions, and future directions.Authorship 101412939Authorship 10141371933741710Arabzade A, Zhao Y, Varadharajan S, Chen HC, Jessa S, Rivas B, Stuckert AJ, Solis M, Kardian A, Tlais D, Golbourn BJ, Stanton AJ, Chan YS, Olson C, Karlin KL, Kong K, Kupp R, Hu B, Injac SG, Ngo M, Wang PR, De Le?n LA, Sahm F, Kawauchi D, Pfister SM, Lin CY, Hodges HC, Singh I, Westbrook TF, Chintagumpala MM, Blaney SM, Parsons DW, Pajtler KW, Agnihotri S, Gilbertson RJ, Yi J, Jabado N, Kleinman CL, Bertrand KC, Deneen B, Mack SCCancer discoveryZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma. 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Int J Mol Sci. 2021 Apr 12; 22(8).Int J Mol Sci2021-04-12T00:00:002021Mapping Astrocyte Transcriptional Signatures in Response to Neuroactive Compounds.true1InstructorInstructorAuthorship 10249601134253626Huang TW, Iyer AA, Manalo JM, Woo J, Bosquez Huerta NA, McGovern MM, Schrewe H, Pereira FA, Groves AK, Ohlemiller KK, Deneen BThe Journal of neuroscience : the official journal of the Society for NeuroscienceGlial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis. J Neurosci. 2021 08 25; 41(34):7171-7181.J Neurosci2021-07-12T00:00:002021Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis.Authorship 10288721134471129Ung K, Huang TW, Lozzi B, Woo J, Hanson E, Pekarek B, Tepe B, Sardar D, Cheng YT, Liu G, Deneen B, Arenkiel BRNature communicationsOlfactory bulb astrocytes mediate sensory circuit processing through Sox9 in the mouse brain. 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Sci Adv. 2023 04 28; 9(17):eade2675.Sci Adv2023-04-28T00:00:002023The genomic landscape of familial glioma.37100909Cheng YT, Luna-Figueroa E, Woo J, Chen HC, Lee ZF, Harmanci AS, Deneen BNatureInhibitory input directs astrocyte morphogenesis through glial GABABR. Nature. 2023 May; 617(7960):369-376.Nature2023-04-26T00:00:002023Inhibitory input directs astrocyte morphogenesis through glial GABABR.37059069Winkler F, Venkatesh HS, Amit M, Batchelor T, Demir IE, Deneen B, Gutmann DH, Hervey-Jumper S, Kuner T, Mabbott D, Platten M, Rolls A, Sloan EK, Wang TC, Wick W, Venkataramani V, Monje MCellCancer neuroscience: State of the field, emerging directions. Cell. 2023 04 13; 186(8):1689-1707.Cell2023-04-13T00:00:002023Cancer neuroscience: State of the field, emerging directions.https://www.hkleelab.orgLee Lab HomepageAuthorship 107311024Authorship 107304015Authorship 1073461937380778Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, McDonald M, He P, Chen HC, Yang Y, Maleki E, Lee ZF, Murali S, Williamson MR, Choi D, Curry R, Bayley J, Woo J, Jalali A, Monje M, Noebels JL, Harmanci AS, Rao G, Deneen BNatureRemote neuronal activity drives glioma progression through SEMA4F. Nature. 2023 Jul; 619(7971):844-850.Nature2023-06-28T00:00:002023Remote neuronal activity drives glioma progression through SEMA4F.37287908Belykh E, Bardonova L, Abramov I, Byvaltsev VA, Kerymbayev T, Yu K, Healey DR, Luna-Melendez E, Deneen B, Mehta S, Liu JK, Preul MCFrontiers in oncology5-aminolevulinic acid, fluorescein sodium, and indocyanine green for glioma margin detection: analysis of operating wide-field and confocal microscopy in glioma models of various grades. Front Oncol. 2023; 13:1156812.Front Oncol2023-05-23T00:00:0020235-aminolevulinic acid, fluorescein sodium, and indocyanine green for glioma margin detection: analysis of operating wide-field and confocal microscopy in glioma models of various grades.37319217Sardar D, Cheng YT, Woo J, Choi DJ, Lee ZF, Kwon W, Chen HC, Lozzi B, Cervantes A, Rajendran K, Huang TW, Jain A, Arenkiel BR, Maze I, Deneen BScience (New York, N.Y.)Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation. Science. 2023 06 16; 380(6650):eade0027.Science2023-06-16T00:00:002023Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation.Authorship 1079369837720399McDonald MF, Prather LL, Helfer CR, Ludmir EB, Echeverria AE, Yust-Katz S, Patel AJ, Deneen B, Rao G, Jalali A, Dhar SU, Amos CI, Mandel JJNeuro-oncology practicePrevalence of pathogenic germline variants in adult-type diffuse glioma. Neurooncol Pract. 2023 Oct; 10(5):482-490.Neurooncol Pract2023-06-21T00:00:002023Prevalence of pathogenic germline variants in adult-type diffuse glioma.Authorship 1080983837816732Williamson MR, Le SP, Franzen RL, Donlan NA, Rosow JL, Nicot-Cartsonis MS, Cervantes A, Deneen B, Dunn AK, Jones TA, Drew MRNature communicationsSubventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke. Nat Commun. 2023 10 10; 14(1):6341.Nat Commun2023-10-10T00:00:002023Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke.true1Associate Professor EmeritusAssociate Professor EmeritusAuthorship 164861Authorship 1085097438113847Fuchs E, Sahai E, Weeraratna AT, Deneen B, Chak-Lui Wong C, Simon ADevelopmental cellUnderstanding the microenvironment and how this controls cell fate. Dev Cell. 2023 Dec 18; 58(24):2819-2821.Dev Cell2023-12-18T00:00:002023Understanding the microenvironment and how this controls cell fate.2031-04-30NIHDENEEN, BENJAMIN2023-05-15Astrocyte Transcriptional Dependencies in Brain CircuitsR35NS1322302025-07-31NIHDENEEN, BENJAMIN2023-08-01Defining Astrocyte Engram Ensembles During Memory FormationR21MH1340022028-08-31NIHMILLS, GORDON B.2023-09-19Systematic Characterization and Targeting of Neomorphic Drivers in CancerU01CA2819022028-07-31NIHMACK, STEPHEN C2023-08-01Transcriptional Regulation in ZFTA-RELA EpendymomaR01CA284455Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorAuthorship 1086706938193532Tripathi S, Nathan CL, Tate MC, Horbinski CM, Templer JW, Rosenow JM, Sita TL, James CD, Deneen B, Miller SD, Heimberger ABJCI insightThe immune system and metabolic products in epilepsy and glioma-associated epilepsy: emerging therapeutic directions. JCI Insight. 2024 Jan 09; 9(1).JCI Insight2024-01-09T00:00:002024The immune system and metabolic products in epilepsy and glioma-associated epilepsy: emerging therapeutic directions.Authorship 1087949838256095Kwon W, Choi DJ, Yu K, Williamson MR, Murali S, Ko Y, Woo J, Deneen BInternational journal of molecular sciencesComparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions. Int J Mol Sci. 2024 Jan 13; 25(2).Int J Mol Sci2024-01-13T00:00:002024Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions.Authorship 10909731838496434Curry RN, Ma Q, McDonald MF, Ko Y, Srivastava S, Chin PS, He P, Lozzi B, Aiba I, Meyer J, Jing J, Wang S, Harmanci AO, Athukuri P, Noebels J, Arenkiel B, Jiang X, Deneen B, Rao G, Harmanci ASbioRxiv : the preprint server for biologySpiking GABAergic OPC tumor cells prolong survival in IDH1 mutant glioma. bioRxiv. 2024 Mar 06.bioRxiv2024-03-06T00:00:002024Spiking GABAergic OPC tumor cells prolong survival in IDH1 mutant glioma.true1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate ProfessorAuthorship 141692624305710Lee JS, Xiao J, Patel P, Schade J, Wang J, Deneen B, Erdreich-Epstein A, Song HRNeuro-oncologyA novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1. 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