SARAHBLUTTSARAH BLUTT0.000000000000000.000000000000002152BLUTT, SARAHAssociate Professorplugins:FeaturedVideosFeatured Videosplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 863091Authorship 869681Authorship 969803Authorship 615201Authorship 7590319075707Blutt SE, Allegretto EA, Pike JW, Weigel NLEndocrinology1,25-dihydroxyvitamin D3 and 9-cis-retinoic acid act synergistically to inhibit the growth of LNCaP prostate cells and cause accumulation of cells in G1. Endocrinology. 1997 Apr; 138(4):1491-7.Endocrinology1997-04-01T00:00:0019971,25-dihydroxyvitamin D3 and 9-cis-retinoic acid act synergistically to inhibit the growth of LNCaP prostate cells and cause accumulation of cells in G1.10352118Blutt SE, Weigel NLProceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)Vitamin D and prostate cancer. Proc Soc Exp Biol Med. 1999 Jun; 221(2):89-98.Proc Soc Exp Biol Med1999-06-01T00:00:001999Vitamin D and prostate cancer.Authorship 300844226446608Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MKJournal of virologyHuman Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol. 2016 01 01; 90(1):43-56.J Virol2015-10-07T00:00:002015Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology.15018288Blutt SE, Conner MEAviation, space, and environmental medicineKinetics of rotavirus infection in mice are not altered in a ground-based model of spaceflight. Aviat Space Environ Med. 2004 Mar; 75(3):215-9.Aviat Space Environ Med2004-03-01T00:00:002004Kinetics of rotavirus infection in mice are not altered in a ground-based model of spaceflight.10614618Blutt SE, McDonnell TJ, Polek TC, Weigel NLEndocrinologyCalcitriol-induced apoptosis in LNCaP cells is blocked by overexpression of Bcl-2. Endocrinology. 2000 Jan; 141(1):10-7.Endocrinology2000-01-01T00:00:002000Calcitriol-induced apoptosis in LNCaP cells is blocked by overexpression of Bcl-2.10706079Blutt SE, Polek TC, Stewart LV, Kattan MW, Weigel NLCancer researchA calcitriol analogue, EB1089, inhibits the growth of LNCaP tumors in nude mice. Cancer Res. 2000 Feb 15; 60(4):779-82.Cancer Res2000-02-15T00:00:002000A calcitriol analogue, EB1089, inhibits the growth of LNCaP tumors in nude mice.12023371Blutt SE, Warfield KL, Lewis DE, Conner MEJournal of immunology (Baltimore, Md. : 1950)Early response to rotavirus infection involves massive B cell activation. J Immunol. 2002 Jun 01; 168(11):5716-21.J Immunol2002-06-01T00:00:002002Early response to rotavirus infection involves massive B cell activation.74Professor10Assistant Professor14Associate Professor46Distinguished Emeritus Professor6Adjunct Professor47Distinguished Service Professor11773387Ciarlet M, Crawford SE, Cheng E, Blutt SE, Rice DA, Bergelson JM, Estes MKJournal of virologyVLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J Virol. 2002 Feb; 76(3):1109-23.J Virol2002-02-01T00:00:002002VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment.Authorship 321388526677228Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz MThe Journal of biological chemistryHuman Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. J Biol Chem. 2016 Feb 19; 291(8):3759-66.J Biol Chem2015-12-16T00:00:002015Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology.17439294Blutt SE, Matson DO, Crawford SE, Staat MA, Azimi P, Bennett BL, Piedra PA, Conner MEPLoS medicineRotavirus antigenemia in children is associated with viremia. PLoS Med. 2007 Apr; 4(4):e121.PLoS Med2007-04-01T00:00:002007Rotavirus antigenemia in children is associated with viremia.15194774Blutt SE, Crawford SE, Warfield KL, Lewis DE, Estes MK, Conner MEJournal of virologyThe VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation. J Virol. 2004 Jul; 78(13):6974-81.J Virol2004-07-01T00:00:002004The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation.Authorship 328068827562956Ettayebi K, Crawford SE, Murakami K, Broughman JR, Karandikar U, Tenge VR, Neill FH, Blutt SE, Zeng XL, Qu L, Kou B, Opekun AR, Burrin D, Graham DY, Ramani S, Atmar RL, Estes MKScience (New York, N.Y.)Replication of human noroviruses in stem cell-derived human enteroids. Science. 2016 09 23; 353(6306):1387-1393.Science2016-08-25T00:00:002016Replication of human noroviruses in stem cell-derived human enteroids.16775359Blutt SE, Fenaux M, Warfield KL, Greenberg HB, Conner MEJournal of virologyActive viremia in rotavirus-infected mice. J Virol. 2006 Jul; 80(13):6702-5.J Virol2006-07-01T00:00:002006Active viremia in rotavirus-infected mice.16191453Blutt SE, Warfield KL, O'Neal CM, Estes MK, Conner MEVaccineHost, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs). Vaccine. 2006 Feb 20; 24(8):1170-9.Vaccine2005-09-09T00:00:002005Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs).17133083Blutt SE, Conner MECurrent opinion in gastroenterologyRotavirus: to the gut and beyond! Curr Opin Gastroenterol. 2007 Jan; 23(1):39-43.Curr Opin Gastroenterol2007-01-01T00:00:002007Rotavirus: to the gut and beyond!17229686Berkova Z, Crawford SE, Blutt SE, Morris AP, Estes MKJournal of virologyExpression of rotavirus NSP4 alters the actin network organization through the actin remodeling protein cofilin. J Virol. 2007 Apr; 81(7):3545-53.J Virol2007-01-17T00:00:002007Expression of rotavirus NSP4 alters the actin network organization through the actin remodeling protein cofilin.18184712Blutt SE, Warfield KL, Estes MK, Conner MEJournal of virologyDifferential requirements for T cells in viruslike particle- and rotavirus-induced protective immunity. J Virol. 2008 Mar; 82(6):3135-8.J Virol2008-01-09T00:00:002008Differential requirements for T cells in viruslike particle- and rotavirus-induced protective immunity.Authorship 6525808Authorship 653624428069942Saxena K, Simon LM, Zeng XL, Blutt SE, Crawford SE, Sastri NP, Karandikar UC, Ajami NJ, Zachos NC, Kovbasnjuk O, Donowitz M, Conner ME, Shaw CA, Estes MKProceedings of the National Academy of Sciences of the United States of AmericaA paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):E570-E579.Proc Natl Acad Sci U S A2017-01-09T00:00:002017A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection.26855967In J, Foulke-Abel J, Zachos NC, Hansen AM, Kaper JB, Bernstein HD, Halushka M, Blutt S, Estes MK, Donowitz M, Kovbasnjuk OCellular and molecular gastroenterology and hepatologyEnterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids. Cell Mol Gastroenterol Hepatol. 2016 Jan 01; 2(1):48-62.e3.Cell Mol Gastroenterol Hepatol2016-01-01T00:00:002016Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids.Authorship 702326428176881Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DLScientific reportsFunctional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep. 2017 02 08; 7:42296.Sci Rep2017-02-08T00:00:002017Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle.21593155Marcelin G, Miller AD, Blutt SE, Conner MEJournal of virologyImmune mediators of rotavirus antigenemia clearance in mice. J Virol. 2011 Aug; 85(15):7937-41.J Virol2011-05-18T00:00:002011Immune mediators of rotavirus antigenemia clearance in mice.22267340Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, Major AM, Venable SF, Finegold MJ, Petrosino JF, Conner ME, Versalovic JFASEB journal : official publication of the Federation of American Societies for Experimental BiologyProbiotics stimulate enterocyte migration and microbial diversity in the neonatal mouse intestine. FASEB J. 2012 May; 26(5):1960-9.FASEB J2012-01-20T00:00:002012Probiotics stimulate enterocyte migration and microbial diversity in the neonatal mouse intestine.Authorship 840348428300206Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DLScientific reportsCorrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep. 2017 03 16; 7:44517.Sci Rep2017-03-16T00:00:002017Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle.23097456Lopatin U, Blutt SE, Conner ME, Kelsall BLJournal of virologyLymphotoxin alpha-deficient mice clear persistent rotavirus infection after local generation of mucosal IgA. J Virol. 2013 Jan; 87(1):524-30.J Virol2012-10-24T00:00:002012Lymphotoxin alpha-deficient mice clear persistent rotavirus infection after local generation of mucosal IgA.28361480Zou WY, Blutt SE, Crawford SE, Ettayebi K, Zeng XL, Saxena K, Ramani S, Karandikar UC, Zachos NC, Estes MKMethods in molecular biology (Clifton, N.J.)Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections. Methods Mol Biol. 2019; 1576:229-247.Methods Mol Biol2019-01-01T00:00:002019Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections.Authorship 8686802Authorship 1031072Authorship 870078128534432Blutt SE, Broughman JR, Zou W, Zeng XL, Karandikar UC, In J, Zachos NC, Kovbasnjuk O, Donowitz M, Estes MKExperimental biology and medicine (Maywood, N.J.)Gastrointestinal microphysiological systems. Exp Biol Med (Maywood). 2017 10; 242(16):1633-1642.Exp Biol Med (Maywood)2017-05-23T00:00:002017Gastrointestinal microphysiological systems.11746268Polek TC, Murthy S, Blutt SE, Boehm MF, Zou A, Weigel NL, Allegretto EAThe ProstateNovel nonsecosteroidal vitamin D receptor modulator inhibits the growth of LNCaP xenograft tumors in athymic mice without increased serum calcium. Prostate. 2001 Nov 01; 49(3):224-33.Prostate2001-11-01T00:00:002001Novel nonsecosteroidal vitamin D receptor modulator inhibits the growth of LNCaP xenograft tumors in athymic mice without increased serum calcium.14602437Blutt SE, Kirkwood CD, Parre?o V, Warfield KL, Ciarlet M, Estes MK, Bok K, Bishop RF, Conner MELancet (London, England)Rotavirus antigenaemia and viraemia: a common event? Lancet. 2003 Nov 01; 362(9394):1445-9.Lancet2003-11-01T00:00:002003Rotavirus antigenaemia and viraemia: a common event?17005639Warfield KL, Blutt SE, Crawford SE, Kang G, Conner MEJournal of virologyRotavirus infection enhances lipopolysaccharide-induced intussusception in a mouse model. J Virol. 2006 Dec; 80(24):12377-86.J Virol2006-09-27T00:00:002006Rotavirus infection enhances lipopolysaccharide-induced intussusception in a mouse model.22343914Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, Major AM, Venable SF, Barrish JP, Finegold MJ, Petrosino JF, Guerrant RL, Conner ME, Versalovic JJournal of pediatric gastroenterology and nutritionHost response to probiotics determined by nutritional status of rotavirus-infected neonatal mice. J Pediatr Gastroenterol Nutr. 2012 Sep; 55(3):299-307.J Pediatr Gastroenterol Nutr2012-09-01T00:00:002012Host response to probiotics determined by nutritional status of rotavirus-infected neonatal mice.22739233Blutt SE, Miller AD, Salmon SL, Metzger DW, Conner MEMucosal immunologyIgA is important for clearance and critical for protection from rotavirus infection. Mucosal Immunol. 2012 Nov; 5(6):712-9.Mucosal Immunol2012-06-27T00:00:002012IgA is important for clearance and critical for protection from rotavirus infection.Authorship 8805282Authorship 8856413Authorship 885688129386123Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MKCell reportsEpithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep. 2018 01 23; 22(4):1003-1015.Cell Rep2018-01-23T00:00:002018Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation.29656244Ramani S, Crawford SE, Blutt SE, Estes MKCurrent opinion in virologyHuman organoid cultures: transformative new tools for human virus studies. Curr Opin Virol. 2018 04; 29:79-86.Curr Opin Virol2018-04-12T00:00:002018Human organoid cultures: transformative new tools for human virus studies.29675450Blutt SE, Crawford SE, Ramani S, Zou WY, Estes MKCellular and molecular gastroenterology and hepatologyEngineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases. Cell Mol Gastroenterol Hepatol. 2018 Mar; 5(3):241-251.Cell Mol Gastroenterol Hepatol2017-12-09T00:00:002017Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases.true1Associate ProfessorAssociate Professor2Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate ProfessorD007413Anatomy35310810.626795Intestinal MucosaD012401Living Beings533770.783206RotavirusD007422Anatomy3056840.697591IntestinesD012400Disorders512870.794081Rotavirus InfectionsD009940Anatomy1302810.806135OrganoidsAuthorship 9151676Authorship 920481129463660Rajan A, Vela L, Zeng XL, Yu X, Shroyer N, Blutt SE, Poole NM, Carlin LG, Nataro JP, Estes MK, Okhuysen PC, Maresso AWmBioNovel Segment- and Host-Specific Patterns of Enteroaggregative Escherichia coli Adherence to Human Intestinal Enteroids. mBio. 2018 02 20; 9(1).mBio2018-02-20T00:00:002018Novel Segment- and Host-Specific Patterns of Enteroaggregative Escherichia coli Adherence to Human Intestinal Enteroids.30182047Blutt SECellular and molecular gastroenterology and hepatologyThe Next MacGyver: A Platform to Study Intestinal Organoids Using High-Throughput Computer-Driven Microinjection. Cell Mol Gastroenterol Hepatol. 2018; 6(3):352-353.Cell Mol Gastroenterol Hepatol2018-07-23T00:00:002018The Next MacGyver: A Platform to Study Intestinal Organoids Using High-Throughput Computer-Driven Microinjection.1900-01-01NIHBLUTT, SARAH E2001-02-25Immune Mechansims of Rotavirus Protection &ClearanaceF32AI010604Principal InvestigatorDepartment of MedicineDepartment of PediatricsDepartment of Molecular & Cellular BiologyDepartment of Molecular Virology & MicrobiologyDepartment of RadiologyRadiologyMedicine-Gastroenterology & HepatolMolecular & Cellular BiologyMolecular Virology & MicrobiologyPediatrics-NewbornBaylor College of MedicineCRISTIANCOARFACRISTIAN COARFA0.000000000000000.000000000000001149COARFA, CRISTIANAssociate ProfessorJAMESCROWEJAMES CROWE0.000000000000000.000000000000001560CROWE, JAMESAssociate Professor3.868270.00526916285research areas7.716660.034750671coauthor of160.1477.1135160similar to1167selected publicationsMARYESTESMARY ESTES0.000000000000000.000000000000002318ESTES, MARYDistinguished Service ProfessorLYNNZECHIEDRICHLYNN ZECHIEDRICH0.000000000000000.000000000000003550ZECHIEDRICH, LYNNProfessorXIAOLIUZHANGXIAOLIU ZHANG0.000000000000000.000000000000003604ZHANG, XIAOLIUAdjunct ProfessorROBERTCOUCHROBERT COUCH0.000000000000000.000000000000002293COUCH, ROBERTDistinguished Emeritus ProfessorWILLIAMGLEZENWILLIAM GLEZEN0.000000000000000.000000000000002351GLEZEN, WILLIAMDistinguished Emeritus ProfessorMARGARETCONNERMARGARET CONNER0.000000000000000.000000000000003085CONNER, MARGARETAssociate ProfessorANDREWRICEANDREW RICE0.000000000000000.000000000000003326RICE, ANDREWProfessorMOHANPAMMIMOHAN PAMMI29.70508570000000-95.40180870000000578PAMMI, MOHANProfessorAuthorship 9524901431336765Estes MK, Ettayebi K, Tenge VR, Murakami K, Karandikar U, Lin SC, Ayyar BV, Cortes-Penfield NW, Haga K, Neill FH, Opekun AR, Broughman JR, Zeng XL, Blutt SE, Crawford SE, Ramani S, Graham DY, Atmar RLVirusesHuman Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges. Viruses. 2019 07 11; 11(7).Viruses2019-07-11T00:00:002019Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges.Authorship 953706231403623Fasciano AC, Blutt SE, Estes MK, Mecsas JJournal of visualized experiments : JoVEInduced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers. J Vis Exp. 2019 07 26; (149).J Vis Exp2019-07-26T00:00:002019Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers.Authorship 956804131589468Blutt SE, Klein OD, Donowitz M, Shroyer N, Guha C, Estes MKAmerican journal of physiology. Gastrointestinal and liver physiologyUse of organoids to study regenerative responses to intestinal damage. Am J Physiol Gastrointest Liver Physiol. 2019 12 01; 317(6):G845-G852.Am J Physiol Gastrointest Liver Physiol2019-10-07T00:00:002019Use of organoids to study regenerative responses to intestinal damage.true1ProfessorProfessortrue1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 961047131726023Blutt SE, Estes MKCell host & microbeGut Bacterial Bouncers: Keeping Viral Pathogens out of the Epithelium. Cell Host Microbe. 2019 11 13; 26(5):569-570.Cell Host Microbe2019-11-13T00:00:002019Gut Bacterial Bouncers: Keeping Viral Pathogens out of the Epithelium.Authorship 1096761Authorship 977827532046599Hewes SA, Wilson RL, Estes MK, Shroyer NF, Blutt SE, Grande-Allen KJTissue engineering. Part B, ReviewsIn Vitro Models of the Small Intestine: Engineering Challenges and Engineering Solutions. Tissue Eng Part B Rev. 2020 08; 26(4):313-326.Tissue Eng Part B Rev2020-03-23T00:00:002020In Vitro Models of the Small Intestine: Engineering Challenges and Engineering Solutions.SASIREKHARAMANISASIREKHA RAMANI0.000000000000000.000000000000005956RAMANI, SASIREKHAAssistant Professortrue1Associate ProfessorAssociate ProfessorAuthorship 9992475Authorship 999599932930708Olvera A, Carter H, Rajan A, Carlin LG, Yu X, Zeng XL, Shelburne S, Bhatti M, Blutt SE, Shroyer NF, Jenq R, Estes MK, Maresso A, Okhuysen PCClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaEnteropathogenic Escherichia coli Infection in Cancer and Immunosuppressed Patients. Clin Infect Dis. 2021 05 18; 72(10):e620-e629.Clin Infect Dis2021-05-18T00:00:002021Enteropathogenic Escherichia coli Infection in Cancer and Immunosuppressed Patients.32907944Lin SC, Qu L, Ettayebi K, Crawford SE, Blutt SE, Robertson MJ, Zeng XL, Tenge VR, Ayyar BV, Karandikar UC, Yu X, Coarfa C, Atmar RL, Ramani S, Estes MKProceedings of the National Academy of Sciences of the United States of AmericaHuman norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23782-23793.Proc Natl Acad Sci U S A2020-09-09T00:00:002020Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids.true1Adjunct ProfessorAdjunct ProfessorAuthorship 9998822332958778Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RANature communicationsTelomere dysfunction activates YAP1 to drive tissue inflammation. Nat Commun. 2020 09 21; 11(1):4766.Nat Commun2020-09-21T00:00:002020Telomere dysfunction activates YAP1 to drive tissue inflammation.Authorship 10010151732986782Rajan A, Robertson MJ, Carter HE, Poole NM, Clark JR, Green SI, Criss ZK, Zhao B, Karandikar U, Xing Y, Margalef-Catal? M, Jain N, Wilson RL, Bai F, Hyser JM, Petrosino J, Shroyer NF, Blutt SE, Coarfa C, Song X, Prasad BV, Amieva MR, Grande-Allen J, Estes MK, Okhuysen PC, Maresso AWPLoS pathogensEnteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection. PLoS Pathog. 2020 09; 16(9):e1008851.PLoS Pathog2020-09-28T00:00:002020Enteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection.Authorship 1003316933089106In JG, Yin J, Atanga R, Doucet M, Cole RN, DeVine L, Donowitz M, Zachos NC, Blutt SE, Estes MK, Kovbasnjuk OiScienceEpithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury. iScience. 2020 Oct 23; 23(10):101618.iScience2020-09-28T00:00:002020Epithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury.Authorship 1005751733246140Hasan NM, Johnson KF, Yin J, Baetz NW, Fayad L, Sherman V, Blutt SE, Estes MK, Kumbhari V, Zachos NC, Kovbasnjuk OMolecular metabolismIntestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis. Mol Metab. 2021 02; 44:101129.Mol Metab2020-11-25T00:00:002020Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis.Authorship 1007086633334213Wilson RL, Swaminathan G, Ettayebi K, Bomidi C, Zeng XL, Blutt SE, Estes MK, Grande-Allen KJTissue engineering. Part C, MethodsProtein-Functionalized Poly(ethylene glycol) Hydrogels as Scaffolds for Monolayer Organoid Culture. Tissue Eng Part C Methods. 2021 01; 27(1):12-23.Tissue Eng Part C Methods2021-01-01T00:00:002021Protein-Functionalized Poly(ethylene glycol) Hydrogels as Scaffolds for Monolayer Organoid Culture.true1ProfessorProfessorAuthorship 1020113334071878Crawford SE, Ramani S, Blutt SE, Estes MKVirusesOrganoids to Dissect Gastrointestinal Virus-Host Interactions: What Have We Learned? Viruses. 2021 05 27; 13(6).Viruses2021-05-27T00:00:002021Organoids to Dissect Gastrointestinal Virus-Host Interactions: What Have We Learned?24348474Blutt SE, Conner MEFrontiers in immunologyThe gastrointestinal frontier: IgA and viruses. Front Immunol. 2013 Nov 28; 4:402.Front Immunol2013-11-28T00:00:002013The gastrointestinal frontier: IgA and viruses.24095866Miller AD, Blutt SE, Conner MEMicrobes and infectionFoxP3+ regulatory T cells are not important for rotavirus clearance or the early antibody response to rotavirus. Microbes Infect. 2014 Jan; 16(1):67-72.Microbes Infect2013-10-02T00:00:002013FoxP3+ regulatory T cells are not important for rotavirus clearance or the early antibody response to rotavirus.Authorship 10249512034253611Chakravarti D, Lee R, Multani AS, Santoni A, Keith Z, Hsu WH, Chang K, Reyes L, Rashid A, Wu CJ, Li J, Zhang J, Shim HS, Chandra K, Deng P, Spring DJ, Nielsen OH, Riis LB, Mayigegowda KK, Blutt SE, Zhang J, Younes M, DuPont A, Thirumurthi S, Vilar E, Estes MK, Colla S, Shroyer NF, DePinho RAProceedings of the National Academy of Sciences of the United States of AmericaTelomere dysfunction instigates inflammation in inflammatory bowel disease. Proc Natl Acad Sci U S A. 2021 07 20; 118(29).Proc Natl Acad Sci U S A2021-07-20T00:00:002021Telomere dysfunction instigates inflammation in inflammatory bowel disease.Authorship 1025799134288725Blutt SE, Crawford SE, Bomidi C, Zeng XL, Broughman JR, Robertson M, Coarfa C, Tessier MEM, Savidge T, Hollinger FB, Curley SA, Donowitz M, Estes MKAmerican journal of physiology. Gastrointestinal and liver physiologyUse of human tissue stem cell-derived organoid cultures to model enterohepatic circulation. Am J Physiol Gastrointest Liver Physiol. 2021 09 01; 321(3):G270-G279.Am J Physiol Gastrointest Liver Physiol2021-07-21T00:00:002021Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation.Authorship 10271321834341793Rajan A, Weaver AM, Aloisio GM, Jelinski J, Johnson HL, Venable SF, McBride T, Aideyan L, Piedra FA, Ye X, Melicoff-Portillo E, Yerramilli MRK, Zeng XL, Mancini MA, Stossi F, Maresso AW, Kotkar SA, Estes MK, Blutt S, Avadhanula V, Piedra PAbioRxiv : the preprint server for biologyThe human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics. bioRxiv. 2021 Jul 28.bioRxiv2021-07-28T00:00:002021The human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics.true1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate ProfessorAuthorship 10310962534612061Criss ZK, Bhasin N, Di Rienzi SC, Rajan A, Deans-Fielder K, Swaminathan G, Kamyabi N, Zeng XL, Doddapaneni H, Menon VK, Chakravarti D, Estrella C, Yu X, Patil K, Petrosino JF, Fleet JC, Verzi MP, Christakos S, Helmrath MA, Arimura S, DePinho RA, Britton RA, Maresso AW, Grande-Allen KJ, Blutt SE, Crawford SE, Estes MK, Ramani S, Shroyer NFPhysiological genomicsDrivers of transcriptional variance in human intestinal epithelial organoids. Physiol Genomics. 2021 11 01; 53(11):486-508.Physiol Genomics2021-10-06T00:00:002021Drivers of transcriptional variance in human intestinal epithelial organoids.Authorship 1031482134644153Blutt SE, Estes MKAnnual review of medicineOrganoid Models for Infectious Disease. Annu Rev Med. 2022 01 27; 73:167-182.Annu Rev Med2021-10-13T00:00:002021Organoid Models for Infectious Disease.Authorship 1033650534732579Bomidi C, Robertson M, Coarfa C, Estes MK, Blutt SEProceedings of the National Academy of Sciences of the United States of AmericaSingle-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection. Proc Natl Acad Sci U S A. 2021 11 09; 118(45).Proc Natl Acad Sci U S A2021-11-09T00:00:002021Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection.Authorship 10399191835164569Rajan A, Weaver AM, Aloisio GM, Jelinski J, Johnson HL, Venable SF, McBride T, Aideyan L, Piedra FA, Ye X, Melicoff-Portillo E, Yerramilli MRK, Zeng XL, Mancini MA, Stossi F, Maresso AW, Kotkar SA, Estes MK, Blutt S, Avadhanula V, Piedra PAmBioThe Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics. mBio. 2021 02 22; 13(1):e0351121.mBio2021-02-22T00:00:002021The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics.Twitter Tweets Harvard Tweets Covid 19 in the neonatal intensive care unitAuthorship 10604733Authorship 10603225Authorship 1054589936336356Bokhari RS, Beheshti A, Blutt SE, Bowles DE, Brenner D, Britton R, Bronk L, Cao X, Chatterjee A, Clay DE, Courtney C, Fox DT, Gaber MW, Gerecht S, Grabham P, Grosshans D, Guan F, Jezuit EA, Kirsch DG, Liu Z, Maletic-Savatic M, Miller KM, Montague RA, Nagpal P, Osenberg S, Parkitny L, Pierce NA, Porada C, Rosenberg SM, Sargunas P, Sharma S, Spangler J, Tavakol DN, Thomas D, Vunjak-Novakovic G, Wang C, Whitcomb L, Young DW, Donoviel DLife sciences in space researchLooking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sci Space Res (Amst). 2022 Nov; 35:105-112.Life Sci Space Res (Amst)2022-08-07T00:00:002022Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel.36640764Castillo-Azofeifa D, Wald T, Reyes EA, Gallagher A, Schanin J, Vlachos S, Lamarche-Vane N, Bomidi C, Blutt S, Estes MK, Nystul T, Klein ODCell stem cellA DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling. Cell Stem Cell. 2023 02 02; 30(2):188-206.e6.Cell Stem Cell2023-01-13T00:00:002023A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling.36688555Tang S, Parks SE, Liao Z, Cope DI, Blutt SE, Monsivais DJournal of visualized experiments : JoVEEstablishing 3D Endometrial Organoids from the Mouse Uterus. J Vis Exp. 2023 01 06; (191).J Vis Exp2023-01-06T00:00:002023Establishing 3D Endometrial Organoids from the Mouse Uterus.true1Distinguished Emeritus ProfessorDistinguished Emeritus Professortrue1Distinguished Emeritus ProfessorDistinguished Emeritus ProfessorAuthorship 107335923Authorship 10740621237292968Adeniyi-Ipadeola GO, Hankins JD, Kambal A, Zeng XL, Patil K, Poplaski V, Bomidi C, Nguyen-Phuc H, Grimm SL, Coarfa C, Stossi F, Crawford SE, Blutt SE, Speer AL, Estes MK, Ramani SbioRxiv : the preprint server for biologyInfant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct. bioRxiv. 2024 Feb 17.bioRxiv2024-02-17T00:00:002024Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct.37398483Carter H, Clark J, Carlin LG, Vaughan E, Rajan A, Olvera A, Yu X, Zeng XL, Kambal A, Holder M, Qin X, Gibbs RA, Petrosino JF, Muzny DM, Doddapaneni H, Menon VK, Hoffman KL, Meng Q, Ross MC, Javornik Cregeen SJ, Metcalf G, Jenq R, Blutt S, Estes MK, TMC-GCID team, Maresso A, Okhuysen PCbioRxiv : the preprint server for biologyFunctional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea. bioRxiv. 2023 Jun 01.bioRxiv2023-06-01T00:00:002023Functional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea.Authorship 1078910137630676Blutt SE, Coarfa C, Neu J, Pammi MMicroorganismsMultiomic Investigations into Lung Health and Disease. Microorganisms. 2023 Aug 19; 11(8).Microorganisms2023-08-19T00:00:002023Multiomic Investigations into Lung Health and Disease.true1ProfessorProfessorAuthorship 10826301837909332Poplaski V, Bomidi C, Kambal A, Nguyen-Phuc H, Di Rienzi SC, Danhof HA, Zeng XL, Feagins LA, Deng N, Vilar E, McAllister F, Coarfa C, Min S, Kim HJ, Shukla R, Britton R, Estes MK, Blutt SEThe Journal of clinical investigationHuman intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation. J Clin Invest. 2023 11 01; 133(21).J Clin Invest2023-11-01T00:00:002023Human intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation.Authorship 148911Authorship 10888681538352333Aloisio GM, Nagaraj D, Murray AM, Schultz EM, McBride T, Aideyan L, Nicholson EG, Henke D, Ferlic-Stark L, Rajan A, Kambal A, Johnson HL, Mosa E, Stossi F, Blutt SE, Piedra PA, Avadhanula VbioRxiv : the preprint server for biologyPediatric human nose organoids demonstrate greater susceptibility, epithelial responses, and cytotoxicity than adults during RSV infection. bioRxiv. 2024 Feb 01.bioRxiv2024-02-01T00:00:002024Pediatric human nose organoids demonstrate greater susceptibility, epithelial responses, and cytotoxicity than adults during RSV infection.Authorship 240101Authorship 288481Authorship 288893Authorship 272223Authorship 1394402NOAHSHROYERNOAH SHROYER7271SHROYER, NOAHAssociate ProfessorAuthorship 335591Authorship 1441721Authorship 431583Authorship 441111Authorship 524393Authorship 523982Authorship 738061Authorship 551094Authorship 150889624719375Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz MExperimental biology and medicine (Maywood, N.J.)Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Exp Biol Med (Maywood). 2014 Sep; 239(9):1124-34.Exp Biol Med (Maywood)2014-04-09T00:00:002014Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract.Authorship 616461Authorship 896991SUECRAWFORDSUE CRAWFORD8067CRAWFORD, SUEAssistant ProfessorAuthorship 96181