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RENAN ORELLANA

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address6621 FANNIN
Houston, TX 77030
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    Collapse Biography 
    Collapse awards and honors
    2012Vernon R. Young International Award for Amino Acid Research, American Society for Nutrition
    2011Samuel J. Fomon Young Physician Award, american Society for Nutrition

    Collapse Research 
    Collapse research activities and funding
    K08AR051563     (ORELLANA, RENAN A)May 1, 2005 - Apr 30, 2011
    NIH
    Regulation of Protein Synthesis in Neonatal Sepsis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nguyen TC, Marini JC, Guillory B, Valladolid-Brown C, Martinez-Vargas M, Subramanyam D, Cohen D, Cirlos SC, Lam F, Stoll B, Didelija IC, Vonderohe C, Orellana R, Saini A, Pradhan S, Bashir D, Desai MS, Flores S, Virk M, Tcharmtchi H, Navaei A, Kaplan S, Lamberth L, Hulten KG, Scull BP, Allen CE, Akcan-Arikan A, Vijayan KV, Cruz MA. Pediatric Swine Model of Methicillin-Resistant Staphylococcus aureus Sepsis-Induced Coagulopathy, Disseminated Microvascular Thrombosis, and Organ Injuries. Crit Care Explor. 2023 Jun; 5(6):e0916. PMID: 37255626; PMCID: PMC10226618.
      Citations:    
    2. Casson N, Sosa-Soto G, Orellana RA, Yock-Corrales A. Pediatric Critical Care Transport: Survey of Current State in Latin America. Latin American Society of Pediatric Intensive Care Transport Committee. Pediatr Emerg Care. 2022 Jan 01; 38(1):e295-e299. PMID: 33105465.
      Citations:    Fields:    Translation:Humans
    3. Navaei AH, Shekerdemian LS, Mohammad MA, Coss-Bu JA, Bastero P, Ettinger NA, Orellana R, Fernandes CJ, Marini JC. Derangement of Arginine and Related Amino Acids in Children Undergoing Surgery for Congenital Heart Disease With Cardiopulmonary Bypass. Crit Care Explor. 2020 Jul; 2(7):e0150. PMID: 32766551; PMCID: PMC7368881.
      Citations: 3     
    4. Branco RG, Orellana RA. Physician Awareness and Management Practices of Fluid Overload in Critically Ill Children. Pediatr Crit Care Med. 2018 10; 19(10):1012-1014. PMID: 30281576.
      Citations:    Fields:    Translation:Humans
    5. El-Kadi SW, Boutry C, Suryawan A, Gazzaneo MC, Srivastava N, Nguyen HV, Kimball SR, Fiorotto ML, Davis TA, Orellana RA. Intermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet model. Am J Clin Nutr. 2018 10 01; 108(4):830-841. PMID: 30239549; PMCID: PMC6186212.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    6. Columbus DA, Nguyen HV, Suryawan A, Davis TA, Hernandez-Garc?a AD, Manjar?n R, Orellana RA. Leucine supplementation stimulates protein synthesis and reduces degradation signal activation in muscle of newborn pigs during acute endotoxemia. Am J Physiol Endocrinol Metab. 2016 10 01; 311(4):E791-E801. PMID: 27624100; PMCID: PMC5241557.
      Citations: 13     Fields:    Translation:AnimalsCells
    7. Suryawan A, Koo SJ, Wilson FA, Nguyen HV, Davis TA, Manjar?n R, Orellana RA. Insulin modulates energy and substrate sensing and protein catabolism induced by chronic peritonitis in skeletal muscle of neonatal pigs. Pediatr Res. 2016 11; 80(5):744-752. PMID: 27508897; PMCID: PMC5746053.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Kyle UG, Lucas LA, Mackey G, Silva JC, Lusk J, Orellana R, Shekerdemian LS, Coss-Bu JA. Implementation of Nutrition Support Guidelines May Affect Energy and Protein Intake in the Pediatric Intensive Care Unit. J Acad Nutr Diet. 2016 05; 116(5):844-851.e4. PMID: 27126156.
      Citations: 2     Fields:    Translation:Humans
    9. Suryawan A, Nguyen HV, Davis TA, Hernandez-Garc?a A, Manjar?n R, Orellana RA. Amino acids, independent of insulin, attenuate skeletal muscle autophagy in neonatal pigs during endotoxemia. Pediatr Res. 2016 09; 80(3):448-51. PMID: 27064245; PMCID: PMC4996682.
      Citations: 4     Fields:    Translation:Animals
    10. Boutry C, El-Kadi SW, Suryawan A, Steinhoff-Wagner J, Stoll B, Nguyen HV, Kimball SR, Fiorotto ML, Davis TA, Orellana RA. Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs. Am J Physiol Endocrinol Metab. 2016 04 15; 310(8):E699-E713. PMID: 26884386; PMCID: PMC4835946.
      Citations: 4     Fields:    Translation:AnimalsCells
    11. Wheatley SM, El-Kadi SW, Suryawan A, Boutry C, Nguyen HV, Davis SR, Davis TA, Orellana RA. Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of ?-hydroxy-?-methylbutyrate. Am J Physiol Endocrinol Metab. 2014 Jan 01; 306(1):E91-9. PMID: 24192287; PMCID: PMC4520576.
      Citations: 15     Fields:    Translation:AnimalsCells
    12. Kyle UG, Spoede ET, Mallory GB, Orellana R, Shekerdemian LS, Schecter MG, Coss-Bu JA. Changes in body composition after lung transplantation in children. J Heart Lung Transplant. 2013 Aug; 32(8):800-6. PMID: 23856217.
      Citations: 3     Fields:    Translation:Humans
    13. Boutry C, El-Kadi SW, Suryawan A, Wheatley SM, Kimball SR, Nguyen HV, Davis TA, Orellana RA. Leucine pulses enhance skeletal muscle protein synthesis during continuous feeding in neonatal pigs. Am J Physiol Endocrinol Metab. 2013 Sep 01; 305(5):E620-31. PMID: 23839523; PMCID: PMC3761169.
      Citations: 24     Fields:    Translation:Animals
    14. El-Kadi SW, Suryawan A, Torrazza RM, Srivastava N, Kimball SR, Nguyen HV, Fiorotto ML, Davis TA, Gazzaneo MC, Orellana RA. Viscera and muscle protein synthesis in neonatal pigs is increased more by intermittent bolus than by continuous feeding. Pediatr Res. 2013 Aug; 74(2):154-62. PMID: 23736770; PMCID: PMC4183190.
      Citations: 8     Fields:    Translation:AnimalsCells
    15. Toole BJ, Toole LE, Kyle UG, Cabrera AG, Coss-Bu JA, Orellana RA. Perioperative nutritional support and malnutrition in infants and children with congenital heart disease. Congenit Heart Dis. 2014 Jan-Feb; 9(1):15-25. PMID: 23602045.
      Citations: 19     Fields:    Translation:Humans
    16. Kyle UG, Akcan-Arikan A, Coss-Bu JA, Orellana RA. Nutrition support among critically ill children with AKI. Clin J Am Soc Nephrol. 2013 Apr; 8(4):568-74. PMID: 23293125; PMCID: PMC3613953.
      Citations: 7     Fields:    Translation:Humans
    17. Suryawan A, Torrazza RM, Gazzaneo MC, Fiorotto ML, El-Kadi SW, Srivastava N, Nguyen HV, Davis TA, Orellana RA. Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways. Pediatr Res. 2012 Apr; 71(4 Pt 1):324-31. PMID: 22391631; PMCID: PMC3619200.
      Citations: 27     Fields:    Translation:AnimalsCells
    18. Suryawan A, Wilson FA, Fiorotto ML, Nguyen HV, Davis TA, Orellana RA, Gazzaneo MC. Development aggravates the severity of skeletal muscle catabolism induced by endotoxemia in neonatal pigs. Am J Physiol Regul Integr Comp Physiol. 2012 Mar 15; 302(6):R682-90. PMID: 22277935; PMCID: PMC4499027.
      Citations: 15     Fields:    Translation:Animals
    19. El-Kadi SW, Suryawan A, Gazzaneo MC, Srivastava N, Nguyen HV, Lobley GE, Davis TA, Orellana RA. Anabolic signaling and protein deposition are enhanced by intermittent compared with continuous feeding in skeletal muscle of neonates. Am J Physiol Endocrinol Metab. 2012 Mar 15; 302(6):E674-86. PMID: 22215651; PMCID: PMC3311296.
      Citations: 19     Fields:    Translation:AnimalsCells
    20. Suryawan A, Torrazza RM, El-Kadi SW, Wilson FA, Kimball SR, Srivastava N, Nguyen HV, Fiorotto ML, Davis TA, Gazzaneo MC, Orellana RA. Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs. J Nutr. 2011 Dec; 141(12):2152-8. PMID: 22013195; PMCID: PMC3223872.
      Citations: 23     Fields:    Translation:AnimalsCells
    21. Suryawan A, Tuckow AP, Kimball SR, Wilson FA, Nguyen HV, Torrazza RM, Fiorotto ML, Davis TA, Gazzaneo MC, Orellana RA. Differential regulation of protein synthesis and mTOR signaling in skeletal muscle and visceral tissues of neonatal pigs after a meal. Pediatr Res. 2011 Sep; 70(3):253-60. PMID: 21654549; PMCID: PMC3152601.
      Citations: 14     Fields:    Translation:AnimalsCells
    22. Wilson FA, Suryawan A, Davis TA, Nguyen HV, Orellana RA, Gazzaneo MC. Sepsis and development impede muscle protein synthesis in neonatal pigs by different ribosomal mechanisms. Pediatr Res. 2011 Jun; 69(6):473-8. PMID: 21364490; PMCID: PMC3090498.
      Citations: 7     Fields:    Translation:AnimalsCells
    23. Murgas Torrazza R, Suryawan A, Gazzaneo MC, Frank JW, Nguyen HV, Fiorotto ML, El-Kadi S, Davis TA, Orellana RA. Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation. J Nutr. 2010 Dec; 140(12):2145-52. PMID: 20962152; PMCID: PMC2981001.
      Citations: 38     Fields:    Translation:AnimalsCells
    24. Wilson FA, Suryawan A, Nguyen HV, Davis TA, Orellana RA, Gazzaneo MC. Differential effects of long-term leucine infusion on tissue protein synthesis in neonatal pigs. Amino Acids. 2011 Jan; 40(1):157-65. PMID: 20505962; PMCID: PMC3139360.
      Citations: 12     Fields:    Translation:AnimalsCells
    25. Wilson FA, Suryawan A, Gazzaneo MC, Nguyen HV, Davis TA, Orellana RA. Stimulation of muscle protein synthesis by prolonged parenteral infusion of leucine is dependent on amino acid availability in neonatal pigs. J Nutr. 2010 Feb; 140(2):264-70. PMID: 20032489; PMCID: PMC2806884.
      Citations: 36     Fields:    Translation:AnimalsCells
    26. Wilson FA, Suryawan A, Kimball SR, Gazzaneo MC, Nguyen HV, Fiorotto ML, Davis TA, Orellana RA. Feeding rapidly stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing translation initiation. J Nutr. 2009 Oct; 139(10):1873-80. PMID: 19692527; PMCID: PMC2744610.
      Citations: 20     Fields:    Translation:AnimalsCells
    27. Suryawan A, Kimball SR, Wu G, Nguyen HV, Jefferson LS, Davis TA, Orellana RA. Insulin signaling in skeletal muscle and liver of neonatal pigs during endotoxemia. Pediatr Res. 2008 Nov; 64(5):505-10. PMID: 18596577; PMCID: PMC2774270.
      Citations: 7     Fields:    Translation:AnimalsCells
    28. Thivierge MC, Bush JA, Suryawan A, Nguyen HV, Orellana RA, Burrin DG, Jahoor F, Davis TA. Positive net movements of amino acids in the hindlimb after overnight food deprivation contribute to sustaining the elevated anabolism of neonatal pigs. J Appl Physiol (1985). 2008 Dec; 105(6):1959-66. PMID: 18801965; PMCID: PMC2612466.
      Citations: 3     Fields:    Translation:Animals
    29. Suryawan A, Jeyapalan AS, Orellana RA, Wilson FA, Nguyen HV, Davis TA. Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E868-75. PMID: 18682538; PMCID: PMC2575905.
      Citations: 60     Fields:    Translation:AnimalsCells
    30. Wilson FA, Suryawan A, Nguyen HV, Jeyapalan AS, Gazzaneo MC, Davis TA, Orellana RA. Fed levels of amino acids are required for the somatotropin-induced increase in muscle protein synthesis. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E876-83. PMID: 18682537; PMCID: PMC3774258.
      Citations: 1     Fields:    Translation:AnimalsCells
    31. Wilson FA, Suryawan A, Nguyen HV, Jeyapalan AS, Frank J, Davis TA, Orellana RA. Stimulation of muscle protein synthesis by somatotropin in pigs is independent of the somatotropin-induced increase in circulating insulin. Am J Physiol Endocrinol Metab. 2008 Jul; 295(1):E187-94. PMID: 18460595; PMCID: PMC3751036.
      Citations: 2     Fields:    Translation:Animals
    32. Suryawan A, Orellana RA, Nguyen HV, Jeyapalan AS, Fleming JR, Davis TA. Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulated. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1597-605. PMID: 17878222; PMCID: PMC2714663.
      Citations: 29     Fields:    Translation:AnimalsCells
    33. Jeyapalan A, Escobar J, Frank JW, Nguyen HV, Suryawan A, Davis TA, Orellana RA. Amino acids augment muscle protein synthesis in neonatal pigs during acute endotoxemia by stimulating mTOR-dependent translation initiation. Am J Physiol Endocrinol Metab. 2007 Nov; 293(5):E1416-25. PMID: 17848637.
      Citations: 17     Fields:    Translation:Animals
    34. Jeyapalan AS, Orellana RA, Suryawan A, O'Connor PM, Nguyen HV, Escobar J, Frank JW, Davis TA. Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent process. Am J Physiol Endocrinol Metab. 2007 Aug; 293(2):E595-603. PMID: 17551002.
      Citations: 16     Fields:    Translation:AnimalsCells
    35. Moffett BS, Orellana R. Use of fenoldopam to increase urine output in a patient with renal insufficiency secondary to septic shock: A case report. Pediatr Crit Care Med. 2006 Nov; 7(6):600-2. PMID: 17006385.
      Citations: 3     Fields:    Translation:Humans
    36. Orellana RA, Kimball SR, Suryawan A, Escobar J, Nguyen HV, Jefferson LS, Davis TA. Insulin stimulates muscle protein synthesis in neonates during endotoxemia despite repression of translation initiation. Am J Physiol Endocrinol Metab. 2007 Feb; 292(2):E629-36. PMID: 17047163.
      Citations: 10     Fields:    Translation:AnimalsCells
    37. Orellana RA, O'Connor PM, Bush JA, Suryawan A, Thivierge MC, Nguyen HV, Fiorotto ML, Davis TA. Modulation of muscle protein synthesis by insulin is maintained during neonatal endotoxemia. Am J Physiol Endocrinol Metab. 2006 Jul; 291(1):E159-66. PMID: 16478773.
      Citations: 9     Fields:    Translation:AnimalsCells
    38. Thivierge MC, Bush JA, Suryawan A, Nguyen HV, Orellana RA, Burrin DG, Jahoor F, Davis TA. Whole-body and hindlimb protein breakdown are differentially altered by feeding in neonatal piglets. J Nutr. 2005 Jun; 135(6):1430-7. PMID: 15930448.
      Citations: 8     Fields:    Translation:AnimalsCells
    39. Kimball SR, Nguyen HV, Bush JA, Suryawan A, Thivierge MC, Jefferson LS, Davis TA, Orellana RA. Regulation of muscle protein synthesis in neonatal pigs during prolonged endotoxemia. Pediatr Res. 2004 Mar; 55(3):442-9. PMID: 14681494.
      Citations: 13     Fields:    Translation:AnimalsCells
    40. Suryawan A, Nguyen HV, Orellana RA, Bush JA, Davis TA. Insulin/insulin-like growth factor-I hybrid receptor abundance decreases with development in suckling pigs. J Nutr. 2003 Sep; 133(9):2783-7. PMID: 12949365.
      Citations: 3     Fields:    Translation:AnimalsCells
    41. Kimball SR, O'Connor PM, Suryawan A, Bush JA, Nguyen HV, Thivierge MC, Jefferson LS, Davis TA, Orellana RA. Endotoxin induces differential regulation of mTOR-dependent signaling in skeletal muscle and liver of neonatal pigs. Am J Physiol Endocrinol Metab. 2003 Sep; 285(3):E637-44. PMID: 12773308.
      Citations: 22     Fields:    Translation:AnimalsCells
    42. Bush JA, Kimball SR, O'Connor PM, Suryawan A, Orellana RA, Nguyen HV, Jefferson LS, Davis TA. Translational control of protein synthesis in muscle and liver of growth hormone-treated pigs. Endocrinology. 2003 Apr; 144(4):1273-83. PMID: 12639910.
      Citations: 14     Fields:    Translation:AnimalsCells
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