CHADCREIGHTONCHAD CREIGHTON0.000000000000000.000000000000001109CREIGHTON, CHADProfessorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson24976077Guzel E, Karatas OF, Semercioz A, Ekici S, Aykan S, Yentur S, Creighton CJ, Ittmann M, Ozen MInternational journal of cancerIdentification of microRNAs differentially expressed in prostatic secretions of patients with prostate cancer. Int J Cancer. 2015 Feb 15; 136(4):875-9.Int J Cancer2014-07-07T00:00:002014Identification of microRNAs differentially expressed in prostatic secretions of patients with prostate cancer.25273528Yu Z, Kim J, He L, Creighton CJ, Gunaratne PH, Hawkins SM, Matzuk MMBiology of reproductionFunctional analysis of miR-34c as a putative tumor suppressor in high-grade serous ovarian cancer. Biol Reprod. 2014 Nov; 91(5):113.Biol Reprod2014-10-01T00:00:002014Functional analysis of miR-34c as a putative tumor suppressor in high-grade serous ovarian cancer.25295534Qin J, Lee HJ, Wu SP, Lin SC, Lanz RB, Creighton CJ, DeMayo FJ, Tsai SY, Tsai MJThe Journal of clinical investigationAndrogen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer. J Clin Invest. 2014 Nov; 124(11):5013-26.J Clin Invest2014-10-08T00:00:002014Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer.25362482Totoki Y, Tatsuno K, Covington KR, Ueda H, Creighton CJ, Kato M, Tsuji S, Donehower LA, Slagle BL, Nakamura H, Yamamoto S, Shinbrot E, Hama N, Lehmkuhl M, Hosoda F, Arai Y, Walker K, Dahdouli M, Gotoh K, Nagae G, Gingras MC, Muzny DM, Ojima H, Shimada K, Midorikawa Y, Goss JA, Cotton R, Hayashi A, Shibahara J, Ishikawa S, Guiteau J, Tanaka M, Urushidate T, Ohashi S, Okada N, Doddapaneni H, Wang M, Zhu Y, Dinh H, Okusaka T, Kokudo N, Kosuge T, Takayama T, Fukayama M, Gibbs RA, Wheeler DA, Aburatani H, Shibata TNature geneticsTrans-ancestry mutational landscape of hepatocellular carcinoma genomes. Nat Genet. 2014 Dec; 46(12):1267-73.Nat Genet2014-11-02T00:00:002014Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.Authorship 80981Authorship 812844Authorship 859937Authorship 849711125579177Zhao S, Kurenbekova L, Gao Y, Roos A, Creighton CJ, Rao P, Hicks J, Man TK, Lau C, Brown AM, Jones SN, Lazar AJ, Ingram D, Lev D, Donehower LA, Yustein JTOncogeneNKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma. Oncogene. 2015 Sep 24; 34(39):5069-79.Oncogene2015-01-12T00:00:002015NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma.Authorship 899075Authorship 899869Authorship 929551Authorship 989971Authorship 1017544Authorship 1051611Authorship 1073755Authorship 1584452Authorship 1214644Authorship 160571Authorship 236791Authorship 1606683Authorship 1609765Authorship 1611965Authorship 1613294Authorship 16169722Authorship 1617402Authorship 1621413Authorship 16219210Authorship 16220913Authorship 1622623Authorship 162300425248926Quint?s-Cardama A, Zhang N, Qiu YH, Post S, Creighton CJ, Cortes J, Coombes KR, Kornblau SMClinical lymphoma, myeloma & leukemiaLoss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015 Feb; 15(2):115-127.e15.Clin Lymphoma Myeloma Leuk2014-08-12T00:00:002014Loss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemia.25421577Addison JB, Koontz C, Fugett JH, Creighton CJ, Chen D, Farrugia MK, Padon RR, Voronkova MA, McLaughlin SL, Livengood RH, Lin CC, Ruppert JM, Pugacheva EN, Ivanov AVCancer researchKAP1 promotes proliferation and metastatic progression of breast cancer cells. Cancer Res. 2015 Jan 15; 75(2):344-55.Cancer Res2014-11-24T00:00:002014KAP1 promotes proliferation and metastatic progression of breast cancer cells.25552398Hadsell DL, Hadsell LA, Olea W, Rijnkels M, Creighton CJ, Smyth I, Short KM, Cox LL, Cox TCMammalian genome : official journal of the International Mammalian Genome SocietyIn-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci. Mamm Genome. 2015 Feb; 26(1-2):57-79.Mamm Genome2015-01-01T00:00:002015In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci.25572662Giuliano M, Herrera S, Christiny P, Shaw C, Creighton CJ, Mitchell T, Bhat R, Zhang X, Mao S, Dobrolecki LE, Al-rawi A, Chen F, Veneziani BM, Zhang XH, Hilsenbeck SG, Contreras A, Gutierrez C, Jeselsohn RM, Rimawi MF, Osborne CK, Lewis MT, Schiff R, Trivedi MVBreast cancer research : BCRCirculating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis. Breast Cancer Res. 2015 Jan 09; 17:3.Breast Cancer Res2015-01-09T00:00:002015Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis.25624393Roarty K, Shore AN, Creighton CJ, Rosen JMThe Journal of cell biologyRor2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium. J Cell Biol. 2015 Feb 02; 208(3):351-66.J Cell Biol2015-01-26T00:00:002015Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium.25664850Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JMThe Journal of clinical investigationLysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest. 2015 Mar 02; 125(3):1147-62.J Clin Invest2015-02-09T00:00:002015Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma.25701100Mishra DK, Creighton CJ, Zhang Y, Chen F, Thrall MJ, Kim MPThe Annals of thoracic surgeryEx vivo four-dimensional lung cancer model mimics metastasis. Ann Thorac Surg. 2015 Apr; 99(4):1149-56.Ann Thorac Surg2015-02-18T00:00:002015Ex vivo four-dimensional lung cancer model mimics metastasis.25749044Zhang L, Shao L, Creighton CJ, Zhang Y, Xin L, Ittmann M, Wang JOncotargetFunction of phosphorylation of NF-kB p65 ser536 in prostate cancer oncogenesis. Oncotarget. 2015 Mar 20; 6(8):6281-94.Oncotarget2015-03-20T00:00:002015Function of phosphorylation of NF-kB p65 ser536 in prostate cancer oncogenesis.25789974Farrugia MK, Sharma SB, Lin CC, McLaughlin SL, Vanderbilt DB, Ammer AG, Salkeni MA, Stoilov P, Agazie YM, Creighton CJ, Ruppert JMCell death & diseaseRegulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer. Cell Death Dis. 2015 Mar 19; 6:e1699.Cell Death Dis2015-03-19T00:00:002015Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer.25805818Yu B, Swatkoski S, Holly A, Lee LC, Giroux V, Lee CS, Hsu D, Smith JL, Yuen G, Yue J, Ann DK, Simpson RM, Creighton CJ, Figg WD, Gucek M, Luo JProceedings of the National Academy of Sciences of the United States of AmericaOncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):E1724-33.Proc Natl Acad Sci U S A2015-03-24T00:00:002015Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9.25859550Rathmell KW, Chen F, Creighton CJOncoscienceGenomics of chromophobe renal cell carcinoma: implications from a rare tumor for pan-cancer studies. Oncoscience. 2015; 2(2):81-90.Oncoscience2015-02-20T00:00:002015Genomics of chromophobe renal cell carcinoma: implications from a rare tumor for pan-cancer studies.Authorship 301361Authorship 31038Authorship 316302Authorship 400672Bioinformatics & Computational BiologyExperimental TherapeuticsGynecological Oncology & Reproductive MedicineMolecular & Cellular OncologySystems BiologyThoracic Head & Neck Medical OncologyTranslational Molecular PathologyMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorJONATHAN MKURIEJONATHAN M KURIE8485KURIE, JONATHAN MProfessorGORDON BMILLSGORDON B MILLS8620MILLS, GORDON BProfessorDON LYNNGIBBONSDON LYNN GIBBONS9342GIBBONS, DON LYNNAssociate ProfessorJOHN NWEINSTEINJOHN N WEINSTEIN9488WEINSTEIN, JOHN NProfessorREHANAKBANIREHAN AKBANI9637AKBANI, REHANAssistant ProfessorGEORGE ACALINGEORGE A CALIN9408CALIN, GEORGE AProfessorANIL KSOODANIL K SOOD9048SOOD, ANIL KProfessorIGNACIO IVANWISTUBAIGNACIO IVAN WISTUBA9098WISTUBA, IGNACIO IVANProfessorAuthorship 480994Authorship 527027Authorship 549078Authorship 564141Authorship 596334Authorship 631372Authorship 666302Authorship 7735410Authorship 787851Authorship 818693Authorship 860527Authorship 867374Authorship 9100112Authorship 927011Authorship 99053One Baylor PlazaHouston, 77030TXAuthorship 2812516Authorship 2812526Authorship 28125317Authorship 2812545Authorship 2812556Authorship 2812565Authorship 281257526721398Monsivais D, Clementi C, Peng J, Titus MM, Barrish JP, Creighton CJ, Lydon JP, DeMayo FJ, Matzuk MMProceedings of the National Academy of Sciences of the United States of AmericaUterine ALK3 is essential during the window of implantation. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):E387-95.Proc Natl Acad Sci U S A2015-12-31T00:00:002015Uterine ALK3 is essential during the window of implantation.26650483Duz MB, Karatas OF, Guzel E, Turgut NF, Yilmaz M, Creighton CJ, Ozen MCellular oncology (Dordrecht)Identification of miR-139-5p as a saliva biomarker for tongue squamous cell carcinoma: a pilot study. Cell Oncol (Dordr). 2016 Apr; 39(2):187-93.Cell Oncol (Dordr)2015-12-09T00:00:002015Identification of miR-139-5p as a saliva biomarker for tongue squamous cell carcinoma: a pilot study.26631572Pankova D, Chen Y, Terajima M, Schliekelman MJ, Baird BN, Fahrenholtz M, Sun L, Gill BJ, Vadakkan TJ, Kim MP, Ahn YH, Roybal JD, Liu X, Parra Cuentas ER, Rodriguez J, Wistuba II, Creighton CJ, Gibbons DL, Hicks JM, Dickinson ME, West JL, Grande-Allen KJ, Hanash SM, Yamauchi M, Kurie JMMolecular cancer research : MCRCancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma. Mol Cancer Res. 2016 Mar; 14(3):287-95.Mol Cancer Res2015-12-02T00:00:002015Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma.26536169Cancer Genome Atlas Research Network, Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, Wheeler DA, Murray BA, Schmidt L, Vocke CD, Peto M, Al Mamun AA, Shinbrot E, Sethi A, Brooks S, Rathmell WK, Brooks AN, Hoadley KA, Robertson AG, Brooks D, Bowlby R, Sadeghi S, Shen H, Weisenberger DJ, Bootwalla M, Baylin SB, Laird PW, Cherniack AD, Saksena G, Haake S, Li J, Liang H, Lu Y, Mills GB, Akbani R, Leiserson MD, Raphael BJ, Anur P, Bottaro D, Albiges L, Barnabas N, Choueiri TK, Czerniak B, Godwin AK, Hakimi AA, Ho TH, Hsieh J, Ittmann M, Kim WY, Krishnan B, Merino MJ, Mills Shaw KR, Reuter VE, Reznik E, Shelley CS, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Tickoo S, Burnett K, Crain D, Gardner J, Lau K, Mallery D, Morris S, Paulauskis JD, Penny RJ, Shelton C, Shelton WT, Sherman M, Thompson E, Yena P, Avedon MT, Bowen J, Gastier-Foster JM, Gerken M, Leraas KM, Lichtenberg TM, Ramirez NC, Santos T, Wise L, Zmuda E, Demchok JA, Felau I, Hutter CM, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Zhang J, Ayala B, Baboud J, Chudamani S, Liu J, Lolla L, Naresh R, Pihl T, Sun Q, Wan Y, Wu Y, Ally A, Balasundaram M, Balu S, Beroukhim R, Bodenheimer T, Buhay C, Butterfield YS, Carlsen R, Carter SL, Chao H, Chuah E, Clarke A, Covington KR, Dahdouli M, Dewal N, Dhalla N, Doddapaneni HV, Drummond JA, Gabriel SB, Gibbs RA, Guin R, Hale W, Hawes A, Hayes DN, Holt RA, Hoyle AP, Jefferys SR, Jones SJ, Jones CD, Kalra D, Kovar C, Lewis L, Li J, Ma Y, Marra MA, Mayo M, Meng S, Meyerson M, Mieczkowski PA, Moore RA, Morton D, Mose LE, Mungall AJ, Muzny D, Parker JS, Perou CM, Roach J, Schein JE, Schumacher SE, Shi Y, Simons JV, Sipahimalani P, Skelly T, Soloway MG, Sougnez C, Tam A, Tan D, Thiessen N, Veluvolu U, Wang M, Wilkerson MD, Wong T, Wu J, Xi L, Zhou J, Bedford J, Chen F, Fu Y, Gerstein M, Haussler D, Kasaian K, Lai P, Ling S, Radenbaugh A, Van Den Berg D, Weinstein JN, Zhu J, Albert M, Alexopoulou I, Andersen JJ, Auman JT, Bartlett J, Bastacky S, Bergsten J, Blute ML, Boice L, Bollag RJ, Boyd J, Castle E, Chen YB, Cheville JC, Curley E, Davies B, DeVolk A, Dhir R, Dike L, Eckman J, Engel J, Harr J, Hrebinko R, Huang M, Huelsenbeck-Dill L, Iacocca M, Jacobs B, Lobis M, Maranchie JK, McMeekin S, Myers J, Nelson J, Parfitt J, Parwani A, Petrelli N, Rabeno B, Roy S, Salner AL, Slaton J, Stanton M, Thompson RH, Thorne L, Tucker K, Weinberger PM, Winemiller C, Zach LA, Zuna RThe New England journal of medicineComprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med. 2016 Jan 14; 374(2):135-45.N Engl J Med2015-11-04T00:00:002015Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.26490990Karatas OF, Suer I, Yuceturk B, Yilmaz M, Hajiyev Y, Creighton CJ, Ittmann M, Ozen MTumour biology : the journal of the International Society for Oncodevelopmental Biology and MedicineThe role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells. Tumour Biol. 2016 Mar; 37(3):4183-92.Tumour Biol2015-10-22T00:00:002015The role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells.26475335Bill KL, Garnett J, Meaux I, Ma X, Creighton CJ, Bolshakov S, Barriere C, Debussche L, Lazar AJ, Prudner BC, Casadei L, Braggio D, Lopez G, Zewdu A, Bid H, Lev D, Pollock REClinical cancer research : an official journal of the American Association for Cancer ResearchSAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma. Clin Cancer Res. 2016 Mar 01; 22(5):1150-60.Clin Cancer Res2015-10-16T00:00:002015SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma.26396249Lopez G, Song Y, Lam R, Ruder D, Creighton CJ, Bid HK, Bill KL, Bolshakov S, Zhang X, Lev D, Pollock REMolecular cancer research : MCRHDAC Inhibition for the Treatment of Epithelioid Sarcoma: Novel Cross Talk Between Epigenetic Components. Mol Cancer Res. 2016 Jan; 14(1):35-43.Mol Cancer Res2015-09-22T00:00:002015HDAC Inhibition for the Treatment of Epithelioid Sarcoma: Novel Cross Talk Between Epigenetic Components.26833126Nikolai BC, Lanz RB, York B, Dasgupta S, Mitsiades N, Creighton CJ, Tsimelzon A, Hilsenbeck SG, Lonard DM, Smith CL, O'Malley BWCancer researchHER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Res. 2016 Mar 15; 76(6):1463-75.Cancer Res2016-02-01T00:00:002016HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes.Authorship 29091111Authorship 2935965Authorship 2961088Authorship 2970471Authorship 2974312Authorship 2978995Authorship 2979354Authorship 2994073Authorship 3006847Authorship 30156611Authorship 3018837Authorship 3026614Authorship 30298010Authorship 3033485Authorship 3037594Authorship 30446013Authorship 30478515Authorship 3059591225151964Zhao D, Pan C, Sun J, Gilbert C, Drews-Elger K, Azzam DJ, Picon-Ruiz M, Kim M, Ullmer W, El-Ashry D, Creighton CJ, Slingerland JMOncogeneVEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2. Oncogene. 2015 Jun 11; 34(24):3107-19.Oncogene2014-08-25T00:00:002014VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2.25798833Kundu ST, Byers LA, Peng DH, Roybal JD, Diao L, Wang J, Tong P, Creighton CJ, Gibbons DLOncogeneThe miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. Oncogene. 2016 Jan 14; 35(2):173-86.Oncogene2015-03-23T00:00:002015The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers.25945817Yilmaz SS, Guzel E, Karatas OF, Yilmaz M, Creighton CJ, Ozen MThe LaryngoscopeMiR-221 as a pre- and postoperative plasma biomarker for larynx cancer patients. Laryngoscope. 2015 Dec; 125(12):E377-81.Laryngoscope2015-05-06T00:00:002015MiR-221 as a pre- and postoperative plasma biomarker for larynx cancer patients.25951106Ozen M, Karatas OF, Gulluoglu S, Bayrak OF, Sevli S, Guzel E, Ekici ID, Caskurlu T, Solak M, Creighton CJ, Ittmann MCancer investigationOverexpression of miR-145-5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression. Cancer Invest. 2015 Jul; 33(6):251-8.Cancer Invest2015-05-07T00:00:002015Overexpression of miR-145-5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression.26019137Feng S, Wang J, Zhang Y, Creighton CJ, Ittmann MOncotargetFGF23 promotes prostate cancer progression. Oncotarget. 2015 Jul 10; 6(19):17291-301.Oncotarget2015-07-10T00:00:002015FGF23 promotes prostate cancer progression.26111976Singh RR, Murugan P, Patel LR, Voicu H, Yoo SY, Majewski T, Mehrotra M, Wani K, Tannir N, Karam JA, Jonasch E, Wood CG, Creighton CJ, Medeiros LJ, Broaddus RR, Tamboli P, Baggerly KA, Aldape KD, Czerniak B, Luthra R, Sircar KModern pathology : an official journal of the United States and Canadian Academy of Pathology, IncIntratumoral morphologic and molecular heterogeneity of rhabdoid renal cell carcinoma: challenges for personalized therapy. Mod Pathol. 2015 Sep; 28(9):1225-35.Mod Pathol2015-06-26T00:00:002015Intratumoral morphologic and molecular heterogeneity of rhabdoid renal cell carcinoma: challenges for personalized therapy.26162852Koparir A, Karatas OF, Yuceturk B, Yuksel B, Bayrak AO, Gerdan OF, Sagiroglu MS, Gezdirici A, Kirimtay K, Selcuk E, Karabay A, Creighton CJ, Yuksel A, Ozen MHuman molecular geneticsNovel POC1A mutation in primordial dwarfism reveals new insights for centriole biogenesis. Hum Mol Genet. 2015 Oct 01; 24(19):5378-87.Hum Mol Genet2015-07-10T00:00:002015Novel POC1A mutation in primordial dwarfism reveals new insights for centriole biogenesis.26166574Zheng ZY, Tian L, Bu W, Fan C, Gao X, Wang H, Liao YH, Li Y, Lewis MT, Edwards D, Zwaka TP, Hilsenbeck SG, Medina D, Perou CM, Creighton CJ, Zhang XH, Chang ECCell reportsWild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation. Cell Rep. 2015 Jul 21; 12(3):511-24.Cell Rep2015-07-09T00:00:002015Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation.26185419Creighton CJ, Huang SDrug design, development and therapyReverse phase protein arrays in signaling pathways: a data integration perspective. Drug Des Devel Ther. 2015; 9:3519-27.Drug Des Devel Ther2015-07-07T00:00:002015Reverse phase protein arrays in signaling pathways: a data integration perspective.26284758Fullerton PT, Creighton CJ, Matzuk MMMolecular endocrinology (Baltimore, Md.)Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-? Signaling. Mol Endocrinol. 2015 Oct; 29(10):1440-53.Mol Endocrinol2015-08-18T00:00:002015Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-? Signaling.26349011Shang H, Braggio D, Lee YJ, Al Sannaa GA, Creighton CJ, Bolshakov S, Lazar AJ, Lev D, Pollock RECancerTargeting the Notch pathway: A potential therapeutic approach for desmoid tumors. Cancer. 2015 Nov 15; 121(22):4088-96.Cancer2015-09-08T00:00:002015Targeting the Notch pathway: A potential therapeutic approach for desmoid tumors.26356605Wu SP, Kao CY, Wang L, Creighton CJ, Yang J, Donti TR, Harmancey R, Vasquez HG, Graham BH, Bellen HJ, Taegtmeyer H, Chang CP, Tsai MJ, Tsai SYNature communicationsIncreased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun. 2015 Sep 10; 6:8245.Nat Commun2015-09-10T00:00:002015Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure.26418340Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BWPLoS geneticsCorrection: Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization. PLoS Genet. 2015 Sep; 11(9):e1005515.PLoS Genet2015-09-29T00:00:002015Correction: Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization.26473186Kim J, Akbani R, Creighton CJ, Lerner SP, Weinstein JN, Getz G, Kwiatkowski DJClinical cancer research : an official journal of the American Association for Cancer ResearchInvasive Bladder Cancer: Genomic Insights and Therapeutic Promise. Clin Cancer Res. 2015 Oct 15; 21(20):4514-24.Clin Cancer Res2015-10-15T00:00:002015Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise.26627007Dogruluk T, Tsang YH, Espitia M, Chen F, Chen T, Chong Z, Appadurai V, Dogruluk A, Eterovic AK, Bonnen PE, Creighton CJ, Chen K, Mills GB, Scott KLCancer researchIdentification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations. Cancer Res. 2015 Dec 15; 75(24):5341-54.Cancer Res2015-12-01T00:00:002015Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations.26728244Ungewiss C, Rizvi ZH, Roybal JD, Peng DH, Gold KA, Shin DH, Creighton CJ, Gibbons DLScientific reportsThe microRNA-200/Zeb1 axis regulates ECM-dependent ?1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL. Sci Rep. 2016 Jan 05; 6:18652.Sci Rep2016-01-05T00:00:002016The microRNA-200/Zeb1 axis regulates ECM-dependent ?1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL.26766592Hakimi AA, Reznik E, Lee CH, Creighton CJ, Brannon AR, Luna A, Aksoy BA, Liu EM, Shen R, Lee W, Chen Y, Stirdivant SM, Russo P, Chen YB, Tickoo SK, Reuter VE, Cheng EH, Sander C, Hsieh JJCancer cellAn Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma. Cancer Cell. 2016 Jan 11; 29(1):104-116.Cancer Cell2016-01-11T00:00:002016An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma.26965145Malorni L, Giuliano M, Migliaccio I, Wang T, Creighton CJ, Lupien M, Fu X, Hilsenbeck SG, Healy N, De Angelis C, Mazumdar A, Trivedi MV, Massarweh S, Gutierrez C, De Placido S, Jeselsohn R, Brown M, Brown PH, Osborne CK, Schiff RMolecular cancer research : MCRBlockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance. Mol Cancer Res. 2016 05; 14(5):470-81.Mol Cancer Res2016-03-10T00:00:002016Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance.10383974Magrini V, Creighton C, Youderian PJournal of bacteriologySite-specific recombination of temperate Myxococcus xanthus phage Mx8: genetic elements required for integration. J Bacteriol. 1999 Jul; 181(13):4050-61.J Bacteriol1999-07-01T00:00:001999Site-specific recombination of temperate Myxococcus xanthus phage Mx8: genetic elements required for integration.15548588Dhanasekaran SM, Dash A, Yu J, Maine IP, Laxman B, Tomlins SA, Creighton CJ, Menon A, Rubin MA, Chinnaiyan AMFASEB journal : official publication of the Federation of American Societies for Experimental BiologyMolecular profiling of human prostate tissues: insights into gene expression patterns of prostate development during puberty. FASEB J. 2005 Feb; 19(2):243-5.FASEB J2004-11-17T00:00:002004Molecular profiling of human prostate tissues: insights into gene expression patterns of prostate development during puberty.74Professor10Assistant Professor14Associate Professor16104058Ping P, Vondriska TM, Creighton CJ, Gandhi TK, Yang Z, Menon R, Kwon MS, Cho SY, Drwal G, Kellmann M, Peri S, Suresh S, Gronborg M, Molina H, Chaerkady R, Rekha B, Shet AS, Gerszten RE, Wu H, Raftery M, Wasinger V, Schulz-Knappe P, Hanash SM, Paik YK, Hancock WS, States DJ, Omenn GS, Pandey AProteomicsA functional annotation of subproteomes in human plasma. Proteomics. 2005 Aug; 5(13):3506-19.Proteomics2005-08-01T00:00:002005A functional annotation of subproteomes in human plasma.12954092Creighton C, Hanash SIn silico biologyExpression of matrix metalloproteinase 9 (MMP-9/gelatinase B) in adenocarcinomas strongly correlated with expression of immune response genes. In Silico Biol. 2003; 3(3):301-11.In Silico Biol2003-01-01T00:00:002003Expression of matrix metalloproteinase 9 (MMP-9/gelatinase B) in adenocarcinomas strongly correlated with expression of immune response genes.Authorship 3207336Authorship 32110440Authorship 3211685Authorship 3215945Authorship 3218594Authorship 3222347Authorship 32226621Authorship 3226194Authorship 3226442326804919Gingras MC, Covington KR, Chang DK, Donehower LA, Gill AJ, Ittmann MM, Creighton CJ, Johns AL, Shinbrot E, Dewal N, Fisher WE, Australian Pancreatic Cancer Genome Initiative, Pilarsky C, Gr?tzmann R, Overman MJ, Jamieson NB, Van Buren G, Drummond J, Walker K, Hampton OA, Xi L, Muzny DM, Doddapaneni H, Lee SL, Bellair M, Hu J, Han Y, Dinh HH, Dahdouli M, Samra JS, Bailey P, Waddell N, Pearson JV, Harliwong I, Wang H, Aust D, Oien KA, Hruban RH, Hodges SE, McElhany A, Saengboonmee C, Duthie FR, Grimmond SM, Biankin AV, Wheeler DA, Gibbs RACell reportsAmpullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation. Cell Rep. 2016 Feb 02; 14(4):907-919.Cell Rep2016-01-21T00:00:002016Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation.26806015Tsang YH, Dogruluk T, Tedeschi PM, Wardwell-Ozgo J, Lu H, Espitia M, Nair N, Minelli R, Chong Z, Chen F, Chang QE, Dennison JB, Dogruluk A, Li M, Ying H, Bertino JR, Gingras MC, Ittmann M, Kerrigan J, Chen K, Creighton CJ, Eterovic K, Mills GB, Scott KLNature communicationsFunctional annotation of rare gene aberration drivers of pancreatic cancer. Nat Commun. 2016 Jan 25; 7:10500.Nat Commun2016-01-25T00:00:002016Functional annotation of rare gene aberration drivers of pancreatic cancer.26917261Roca FJ, Loomans HA, Wittman AT, Creighton CJ, Hawkins SMCurrent molecular medicineTen-Eleven Translocation Genes are Downregulated in Endometriosis. Curr Mol Med. 2016; 16(3):288-98.Curr Mol Med2016-01-01T00:00:002016Ten-Eleven Translocation Genes are Downregulated in Endometriosis.26923594Park JH, Vithayathil S, Kumar S, Sung PL, Dobrolecki LE, Putluri V, Bhat VB, Bhowmik SK, Gupta V, Arora K, Wu D, Tsouko E, Zhang Y, Maity S, Donti TR, Graham BH, Frigo DE, Coarfa C, Yotnda P, Putluri N, Sreekumar A, Lewis MT, Creighton CJ, Wong LC, Kaipparettu BACell reportsFatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer. Cell Rep. 2016 Mar 08; 14(9):2154-2165.Cell Rep2016-02-25T00:00:002016Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer.26947078Chen F, Zhang Y, Senbabaoglu Y, Ciriello G, Yang L, Reznik E, Shuch B, Micevic G, De Velasco G, Shinbrot E, Noble MS, Lu Y, Covington KR, Xi L, Drummond JA, Muzny D, Kang H, Lee J, Tamboli P, Reuter V, Shelley CS, Kaipparettu BA, Bottaro DP, Godwin AK, Gibbs RA, Getz G, Kucherlapati R, Park PJ, Sander C, Henske EP, Zhou JH, Kwiatkowski DJ, Ho TH, Choueiri TK, Hsieh JJ, Akbani R, Mills GB, Hakimi AA, Wheeler DA, Creighton CJCell reportsMultilevel Genomics-Based Taxonomy of Renal Cell Carcinoma. Cell Rep. 2016 Mar 15; 14(10):2476-89.Cell Rep2016-03-03T00:00:002016Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.27018534Vasquez YM, Wu SP, Anderson ML, Hawkins SM, Creighton CJ, Ray M, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJMolecular endocrinology (Baltimore, Md.)Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis. Mol Endocrinol. 2016 May; 30(5):518-32.Mol Endocrinol2016-03-28T00:00:002016Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.27108958Lin SC, Kao CY, Lee HJ, Creighton CJ, Ittmann MM, Tsai SJ, Tsai SY, Tsai MJNature communicationsDysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun. 2016 04 25; 7:11418.Nat Commun2016-04-25T00:00:002016Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer.16804865Haas CS, Creighton CJ, Pi X, Maine I, Koch AE, Haines GK, Ling S, Chinnaiyan AM, Holoshitz JArthritis and rheumatismIdentification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins. Arthritis Rheum. 2006 Jul; 54(7):2047-60.Arthritis Rheum2006-07-01T00:00:002006Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins.16834787Creighton CJ, Rae JMBreast cancer research : BCRWhen will tumor gene expression profiling be incorporated into clinical breast cancer decision making? Breast Cancer Res. 2006; 8(4):302.Breast Cancer Res2006-01-01T00:00:002006When will tumor gene expression profiling be incorporated into clinical breast cancer decision making?Authorship 3247009Authorship 3251117Authorship 3253444Authorship 3254373Authorship 32559010Authorship 3257071027294523Kwon OJ, Zhang L, Wang J, Su Q, Feng Q, Zhang XH, Mani SA, Paulter R, Creighton CJ, Ittmann MM, Xin LThe Journal of clinical investigationNotch promotes tumor metastasis in a prostate-specific Pten-null mouse model. J Clin Invest. 2016 07 01; 126(7):2626-41.J Clin Invest2016-06-13T00:00:002016Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model.27403603Farach A, Ding Y, Lee M, Creighton C, Delk NA, Ittmann M, Miles B, Rowley D, Farach-Carson MC, Ayala GEThe ProstateNeuronal Trans-Differentiation in Prostate Cancer Cells. Prostate. 2016 10; 76(14):1312-25.Prostate2016-07-12T00:00:002016Neuronal Trans-Differentiation in Prostate Cancer Cells.27456471Zhang T, Guo L, Creighton CJ, Lu Q, Gibbons DL, Yi ES, Deng B, Molina JR, Sun Z, Yang P, Yang YNature communicationsA genetic cell context-dependent role for ZEB1 in lung cancer. Nat Commun. 2016 07 26; 7:12231.Nat Commun2016-07-26T00:00:002016A genetic cell context-dependent role for ZEB1 in lung cancer.27484008Malouf GG, Comp?rat E, Yao H, Mouawad R, Lindner V, Rioux-Leclercq N, Verkarre V, Leroy X, Dainese L, Classe M, Descotes JL, Barthelemy P, Yacoub M, Roupr?t M, Bernhard JC, Creighton CJ, Spano JP, Su X, Khayat DScientific reportsUnique Transcriptomic Profile of Collecting Duct Carcinomas Relative to Upper Tract Urothelial Carcinomas and other Kidney Carcinomas. Sci Rep. 2016 08 03; 6:30988.Sci Rep2016-08-03T00:00:002016Unique Transcriptomic Profile of Collecting Duct Carcinomas Relative to Upper Tract Urothelial Carcinomas and other Kidney Carcinomas.26993130Wander SA, Zhao D, Besser AH, Hong F, Wei J, Ince TA, Milikowski C, Bishopric NH, Minn AJ, Creighton CJ, Slingerland JMBreast cancer research and treatmentErratum to: PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy. Breast Cancer Res Treat. 2016 Apr; 156(2):405-6.Breast Cancer Res Treat2016-04-01T00:00:002016Erratum to: PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy.27130845Scelo G, Hofmann JN, Banks RE, Bigot P, Bhatt RS, Cancel-Tassin G, Chew SK, Creighton CJ, Cussenot O, Davis IJ, Escudier B, Frayling TM, H?ggstr?m C, Hildebrandt MA, Holcatova I, Johansson M, Linehan WM, McDermott DF, Nathanson KL, Ogawa S, Perlman EJ, Purdue MP, Stattin P, Swanton C, Vasudev NS, Wu X, Znaor A, Brennan P, Chanock SJAnnals of oncology : official journal of the European Society for Medical OncologyInternational cancer seminars: a focus on kidney cancer. Ann Oncol. 2016 08; 27(8):1382-5.Ann Oncol2016-04-29T00:00:002016International cancer seminars: a focus on kidney cancer.17004106Rae JM, Creighton CJ, Meck JM, Haddad BR, Johnson MDBreast cancer research and treatmentMDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma research. Breast Cancer Res Treat. 2007 Jul; 104(1):13-9.Breast Cancer Res Treat2006-09-27T00:00:002006MDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma research.Authorship 3262951627481130Verstovsek S, Manshouri T, Pilling D, Bueso-Ramos CE, Newberry KJ, Prijic S, Knez L, Bozinovic K, Harris DM, Spaeth EL, Post SM, Multani AS, Rampal RK, Ahn J, Levine RL, Creighton CJ, Kantarjian HM, Estrov ZThe Journal of experimental medicineRole of neoplastic monocyte-derived fibrocytes in primary myelofibrosis. J Exp Med. 2016 08 22; 213(9):1723-40.J Exp Med2016-08-01T00:00:002016Role of neoplastic monocyte-derived fibrocytes in primary myelofibrosis.Authorship 3274471627594448Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj GV, Mauck R, Roehrborn C, Creighton CJ, Strand DW, Ittmann MM, Xin LMolecular cellNon-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor. Mol Cell. 2016 09 15; 63(6):976-89.Mol Cell2016-09-01T00:00:002016Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor.12844362Creighton C, Kuick R, Misek DE, Rickman DS, Brichory FM, Rouillard JM, Omenn GS, Hanash SGenome biologyProfiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice. Genome Biol. 2003; 4(7):R46.Genome Biol2003-06-23T00:00:002003Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice.18350153Creighton CJPloS oneMultiple oncogenic pathway signatures show coordinate expression patterns in human prostate tumors. PLoS One. 2008 Mar 19; 3(3):e1816.PLoS One2008-03-19T00:00:002008Multiple oncogenic pathway signatures show coordinate expression patterns in human prostate tumors.18757322Creighton CJ, Casa A, Lazard Z, Huang S, Tsimelzon A, Hilsenbeck SG, Osborne CK, Lee AVJournal of clinical oncology : official journal of the American Society of Clinical OncologyInsulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis. J Clin Oncol. 2008 Sep 01; 26(25):4078-85.J Clin Oncol2008-09-01T00:00:002008Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis.14597962Hanash S, Creighton CThe pharmacogenomics journalMaking sense of microarray data to classify cancer. Pharmacogenomics J. 2003; 3(6):308-11.Pharmacogenomics J2003-01-01T00:00:002003Making sense of microarray data to classify cancer.15798092Creighton CJ, Bromberg-White JL, Misek DE, Monsma DJ, Brichory F, Kuick R, Giordano TJ, Gao W, Omenn GS, Webb CP, Hanash SMMolecular cancer research : MCRAnalysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation. Mol Cancer Res. 2005 Mar; 3(3):119-29.Mol Cancer Res2005-03-01T00:00:002005Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation.19490893Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJCellA genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell. 2009 May 29; 137(5):835-48.Cell2009-05-29T00:00:002009A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.19759262Gibbons DL, Lin W, Creighton CJ, Rizvi ZH, Gregory PA, Goodall GJ, Thilaganathan N, Du L, Zhang Y, Pertsemlidis A, Kurie JMGenes & developmentContextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes Dev. 2009 Sep 15; 23(18):2140-51.Genes Dev2009-09-15T00:00:002009Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression.19827049Zhang L, Zhao W, Valdez JM, Creighton CJ, Xin LThe ProstateLow-density Taqman miRNA array reveals miRNAs differentially expressed in prostatic stem cells and luminal cells. Prostate. 2010 Feb 15; 70(3):297-304.Prostate2010-02-15T00:00:002010Low-density Taqman miRNA array reveals miRNAs differentially expressed in prostatic stem cells and luminal cells.20054865LaMarca HL, Visbal AP, Creighton CJ, Liu H, Zhang Y, Behbod F, Rosen JMStem cells (Dayton, Ohio)CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland. Stem Cells. 2010 Mar 31; 28(3):535-44.Stem Cells2010-03-31T00:00:002010CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland.21376233Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TFCellActivation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 2011 Mar 04; 144(5):703-18.Cell2011-03-04T00:00:002011Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.21436257Hawkins SM, Creighton CJ, Han DY, Zariff A, Anderson ML, Gunaratne PH, Matzuk MMMolecular endocrinology (Baltimore, Md.)Functional microRNA involved in endometriosis. Mol Endocrinol. 2011 May; 25(5):821-32.Mol Endocrinol2011-03-24T00:00:002011Functional microRNA involved in endometriosis.Authorship 32812911Authorship 3281921627624071Treekitkarnmongkol W, Katayama H, Kai K, Sasai K, Jones JC, Wang J, Shen L, Sahin AA, Gagea M, Ueno NT, Creighton CJ, Sen SCarcinogenesisAurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer. Carcinogenesis. 2016 Dec; 37(12):1180-1189.Carcinogenesis2016-09-13T00:00:002016Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer.27694892Peng DH, Ungewiss C, Tong P, Byers LA, Wang J, Canales JR, Villalobos PA, Uraoka N, Mino B, Behrens C, Wistuba II, Han RI, Wanna CA, Fahrenholtz M, Grande-Allen KJ, Creighton CJ, Gibbons DLOncogeneZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis. Oncogene. 2017 04 06; 36(14):1925-1938.Oncogene2016-10-03T00:00:002016ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis.21512135Manshouri T, Estrov Z, Quint?s-Cardama A, Burger J, Zhang Y, Livun A, Knez L, Harris D, Creighton CJ, Kantarjian HM, Verstovsek SCancer researchBone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res. 2011 Jun 01; 71(11):3831-40.Cancer Res2011-04-21T00:00:002011Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor.21533284Helland ?, Anglesio MS, George J, Cowin PA, Johnstone CN, House CM, Sheppard KE, Etemadmoghadam D, Melnyk N, Rustgi AK, Phillips WA, Johnsen H, Holm R, Kristensen GB, Birrer MJ, Australian Ovarian Cancer Study Group, Pearson RB, B?rresen-Dale AL, Huntsman DG, deFazio A, Creighton CJ, Smyth GK, Bowtell DDPloS oneDeregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers. PLoS One. 2011 Apr 13; 6(4):e18064.PLoS One2011-04-13T00:00:002011Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.21541704Casa AJ, Potter AS, Malik S, Lazard Z, Kuiatse I, Kim HT, Tsimelzon A, Creighton CJ, Hilsenbeck SG, Brown PH, Oesterreich S, Lee AVBreast cancer research and treatmentEstrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growth. Breast Cancer Res Treat. 2012 Feb; 132(1):61-73.Breast Cancer Res Treat2011-05-04T00:00:002011Estrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growth.21614627Ghadimi MP, Al-Zaid T, Madewell J, Peng T, Colombo C, Hoffman A, Creighton CJ, Zhang Y, Zhang A, Lazar AJ, Pollock RE, Lev DAnnals of surgical oncologyDiagnosis, management, and outcome of patients with dedifferentiated liposarcoma systemic metastasis. Ann Surg Oncol. 2011 Dec; 18(13):3762-70.Ann Surg Oncol2011-05-26T00:00:002011Diagnosis, management, and outcome of patients with dedifferentiated liposarcoma systemic metastasis.16585219Creighton CJ, Hilger AM, Murthy S, Rae JM, Chinnaiyan AM, El-Ashry DCancer researchActivation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors. Cancer Res. 2006 Apr 01; 66(7):3903-11.Cancer Res2006-04-01T00:00:002006Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors.16606439Creighton CJ, Cordero KE, Larios JM, Miller RS, Johnson MD, Chinnaiyan AM, Lippman ME, Rae JMGenome biologyGenes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors. Genome Biol. 2006; 7(4):R28.Genome Biol2006-04-07T00:00:002006Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors.21826666Colombo C, Creighton CJ, Ghadimi MP, Bolshakov S, Warneke CL, Zhang Y, Lusby K, Zhu S, Lazar AJ, West RB, van de Rijn M, Lev DThe Journal of pathologyIncreased midkine expression correlates with desmoid tumour recurrence: a potential biomarker and therapeutic target. J Pathol. 2011 Dec; 225(4):574-82.J Pathol2011-08-08T00:00:002011Increased midkine expression correlates with desmoid tumour recurrence: a potential biomarker and therapeutic target.22517119Quint?s-Cardama A, Qiu YH, Post SM, Zhang Y, Creighton CJ, Cortes J, Kornblau SMCancerReverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment. Cancer. 2012 Nov 01; 118(21):5283-92.Cancer2012-04-19T00:00:002012Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment.22850877Ahn YH, Gibbons DL, Chakravarti D, Creighton CJ, Rizvi ZH, Adams HP, Pertsemlidis A, Gregory PA, Wright JA, Goodall GJ, Flores ER, Kurie JMThe Journal of clinical investigationZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. J Clin Invest. 2012 Sep; 122(9):3170-83.J Clin Invest2012-08-01T00:00:002012ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.22911650Shore AN, Kabotyanski EB, Roarty K, Smith MA, Zhang Y, Creighton CJ, Dinger ME, Rosen JMPLoS geneticsPregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation. PLoS Genet. 2012; 8(7):e1002840.PLoS Genet2012-07-26T00:00:002012Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation.22956860Creighton CJBiologics : targets & therapyThe molecular profile of luminal B breast cancer. Biologics. 2012; 6:289-97.Biologics2012-08-24T00:00:002012The molecular profile of luminal B breast cancer.22960745Cancer Genome Atlas Research NetworkNatureComprehensive genomic characterization of squamous cell lung cancers. Nature. 2012 Sep 27; 489(7417):519-25.Nature2012-09-09T00:00:002012Comprehensive genomic characterization of squamous cell lung cancers.17213801Creighton CJOncogeneA gene transcription signature of the Akt/mTOR pathway in clinical breast tumors. Oncogene. 2007 Jul 12; 26(32):4648-55.Oncogene2007-01-08T00:00:002007A gene transcription signature of the Akt/mTOR pathway in clinical breast tumors.23401071Hoffman A, Ghadimi MP, Demicco EG, Creighton CJ, Torres K, Colombo C, Peng T, Lusby K, Ingram D, Hornick JL, Wang WL, Ravi V, Lazar AJ, Lev D, Pollock RECancerLocalized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations. Cancer. 2013 May 15; 119(10):1868-77.Cancer2013-02-07T00:00:002013Localized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations.23440425Feng S, Dakhova O, Creighton CJ, Ittmann MCancer researchEndocrine fibroblast growth factor FGF19 promotes prostate cancer progression. Cancer Res. 2013 Apr 15; 73(8):2551-62.Cancer Res2013-02-25T00:00:002013Endocrine fibroblast growth factor FGF19 promotes prostate cancer progression.27791031Fu X, Jeselsohn R, Pereira R, Hollingsworth EF, Creighton CJ, Li F, Shea M, Nardone A, De Angelis C, Heiser LM, Anur P, Wang N, Grasso CS, Spellman PT, Griffith OL, Tsimelzon A, Gutierrez C, Huang S, Edwards DP, Trivedi MV, Rimawi MF, Lopez-Terrada D, Hilsenbeck SG, Gray JW, Brown M, Osborne CK, Schiff RProceedings of the National Academy of Sciences of the United States of AmericaFOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):E6600-E6609.Proc Natl Acad Sci U S A2016-10-06T00:00:002016FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer.17598908Creighton CJBMC genomicsA gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers. BMC Genomics. 2007 Jun 28; 8:199.BMC Genomics2007-06-28T00:00:002007A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers.Authorship 513206517891175Ozen M, Creighton CJ, Ozdemir M, Ittmann MOncogeneWidespread deregulation of microRNA expression in human prostate cancer. Oncogene. 2008 Mar 13; 27(12):1788-93.Oncogene2007-09-24T00:00:002007Widespread deregulation of microRNA expression in human prostate cancer.17996646Yu J, Cao Q, Mehra R, Laxman B, Yu J, Tomlins SA, Creighton CJ, Dhanasekaran SM, Shen R, Chen G, Morris DS, Marquez VE, Shah RB, Ghosh D, Varambally S, Chinnaiyan AMCancer cellIntegrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer. Cancer Cell. 2007 Nov; 12(5):419-31.Cancer Cell2007-11-01T00:00:002007Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer.18245484Massarweh S, Osborne CK, Creighton CJ, Qin L, Tsimelzon A, Huang S, Weiss H, Rimawi M, Schiff RCancer researchTamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function. Cancer Res. 2008 Feb 01; 68(3):826-33.Cancer Res2008-02-01T00:00:002008Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function.18812437Creighton CJ, Nagaraja AK, Hanash SM, Matzuk MM, Gunaratne PHRNA (New York, N.Y.)A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions. RNA. 2008 Nov; 14(11):2290-6.RNA2008-09-23T00:00:002008A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions.18794137Creighton CJ, Massarweh S, Huang S, Tsimelzon A, Hilsenbeck SG, Osborne CK, Shou J, Malorni L, Schiff RCancer researchDevelopment of resistance to targeted therapies transforms the clinically associated molecular profile subtype of breast tumor xenografts. Cancer Res. 2008 Sep 15; 68(18):7493-501.Cancer Res2008-09-15T00:00:002008Development of resistance to targeted therapies transforms the clinically associated molecular profile subtype of breast tumor xenografts.19242612Castro P, Creighton CJ, Ozen M, Berel D, Mims MP, Ittmann MNeoplasia (New York, N.Y.)Genomic profiling of prostate cancers from African American men. Neoplasia. 2009 Mar; 11(3):305-12.Neoplasia2009-03-01T00:00:002009Genomic profiling of prostate cancers from African American men.19332473Creighton CJ, Reid JG, Gunaratne PHBriefings in bioinformaticsExpression profiling of microRNAs by deep sequencing. Brief Bioinform. 2009 Sep; 10(5):490-7.Brief Bioinform2009-03-30T00:00:002009Expression profiling of microRNAs by deep sequencing.19404390Gibbons DL, Lin W, Creighton CJ, Zheng S, Berel D, Yang Y, Raso MG, Liu DD, Wistuba II, Lozano G, Kurie JMPloS oneExpression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. PLoS One. 2009; 4(4):e5401.PLoS One2009-04-30T00:00:002009Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma.19509179Dakhova O, Ozen M, Creighton CJ, Li R, Ayala G, Rowley D, Ittmann MClinical cancer research : an official journal of the American Association for Cancer ResearchGlobal gene expression analysis of reactive stroma in prostate cancer. Clin Cancer Res. 2009 Jun 15; 15(12):3979-89.Clin Cancer Res2009-06-09T00:00:002009Global gene expression analysis of reactive stroma in prostate cancer.Authorship 6518221Authorship 6524393Authorship 65263512Authorship 65291915Authorship 6529519Authorship 6536362Authorship 6538738Authorship 654446623869198Creighton CJBreast cancer managementUsing large-scale molecular data sets to improve breast cancer treatment. Breast Cancer Manag. 2012 May 01; 1(1):57-64.Breast Cancer Manag2012-05-01T00:00:002012Using large-scale molecular data sets to improve breast cancer treatment.27256309Malouf GG, Su X, Zhang J, Creighton CJ, Ho TH, Lu Y, Raynal NJ, Karam JA, Tamboli P, Allanick F, Mouawad R, Spano JP, Khayat D, Wood CG, Jelinek J, Tannir NMClinical cancer research : an official journal of the American Association for Cancer ResearchDNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas. Clin Cancer Res. 2016 Dec 15; 22(24):6236-6246.Clin Cancer Res2016-06-02T00:00:002016DNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas.27775076Chen F, Zhang Y, Parra E, Rodriguez J, Behrens C, Akbani R, Lu Y, Kurie JM, Gibbons DL, Mills GB, Wistuba II, Creighton CJOncogeneMultiplatform-based molecular subtypes of non-small-cell lung cancer. Oncogene. 2017 03; 36(10):1384-1393.Oncogene2016-10-24T00:00:002016Multiplatform-based molecular subtypes of non-small-cell lung cancer.27816053Karatas OF, Suer I, Yuceturk B, Yilmaz M, Oz B, Guven G, Cansiz H, Creighton CJ, Ittmann M, Ozen MBMC cancerIdentification of microRNA profile specific to cancer stem-like cells directly isolated from human larynx cancer specimens. BMC Cancer. 2016 11 05; 16(1):853.BMC Cancer2016-11-05T00:00:002016Identification of microRNA profile specific to cancer stem-like cells directly isolated from human larynx cancer specimens.19666588Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, Sjolund A, Rimm DL, Wong H, Rodriguez A, Herschkowitz JI, Fan C, Zhang X, He X, Pavlick A, Gutierrez MC, Renshaw L, Larionov AA, Faratian D, Hilsenbeck SG, Perou CM, Lewis MT, Rosen JM, Chang JCProceedings of the National Academy of Sciences of the United States of AmericaResidual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):13820-5.Proc Natl Acad Sci U S A2009-08-03T00:00:002009Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features.27869652Tan X, Banerjee P, Guo HF, Ireland S, Pankova D, Ahn YH, Nikolaidis IM, Liu X, Zhao Y, Xue Y, Burns AR, Roybal J, Gibbons DL, Zal T, Creighton CJ, Ungar D, Wang Y, Kurie JMThe Journal of clinical investigationEpithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11. J Clin Invest. 2017 01 03; 127(1):117-131.J Clin Invest2016-11-21T00:00:002016Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11.27881777Chaboub LS, Manalo JM, Lee HK, Glasgow SM, Chen F, Kawasaki Y, Akiyama T, Kuo CT, Creighton CJ, Mohila CA, Deneen BThe Journal of neuroscience : the official journal of the Society for NeuroscienceTemporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. J Neurosci. 2016 11 23; 36(47):11904-11917.J Neurosci2016-11-23T00:00:002016Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury.28045625Ellis MJ, Suman VJ, Hoog J, Goncalves R, Sanati S, Creighton CJ, DeSchryver K, Crouch E, Brink A, Watson M, Luo J, Tao Y, Barnes M, Dowsett M, Budd GT, Winer E, Silverman P, Esserman L, Carey L, Ma CX, Unzeitig G, Pluard T, Whitworth P, Babiera G, Guenther JM, Dayao Z, Ota D, Leitch M, Olson JA, Allred DC, Hunt KJournal of clinical oncology : official journal of the American Society of Clinical OncologyKi67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance). J Clin Oncol. 2017 Apr 01; 35(10):1061-1069.J Clin Oncol2017-01-03T00:00:002017Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance).28073171Gibbons DL, Creighton CJDevelopmental dynamics : an official publication of the American Association of AnatomistsPan-cancer survey of epithelial-mesenchymal transition markers across the Cancer Genome Atlas. Dev Dyn. 2018 03; 247(3):555-564.Dev Dyn2017-05-04T00:00:002017Pan-cancer survey of epithelial-mesenchymal transition markers across the Cancer Genome Atlas.19901029Hammerich-Hille S, Kaipparettu BA, Tsimelzon A, Creighton CJ, Jiang S, Polo JM, Melnick A, Meyer R, Oesterreich SThe Journal of biological chemistrySAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells. J Biol Chem. 2010 Feb 05; 285(6):3608-3616.J Biol Chem2009-11-09T00:00:002009SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells.19909553Chang CC, Zhou X, Taylor JJ, Huang WT, Ren X, Monzon F, Feng Y, Rao PH, Lu XY, Fabio F, Hilsenbeck S, Creighton CJ, Jaffe ES, Lau CCJournal of hematology & oncologyGenomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma. J Hematol Oncol. 2009 Nov 12; 2:47.J Hematol Oncol2009-11-12T00:00:002009Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma.20081105Nagaraja AK, Creighton CJ, Yu Z, Zhu H, Gunaratne PH, Reid JG, Olokpa E, Itamochi H, Ueno NT, Hawkins SM, Anderson ML, Matzuk MMMolecular endocrinology (Baltimore, Md.)A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer. Mol Endocrinol. 2010 Feb; 24(2):447-63.Mol Endocrinol2010-01-15T00:00:002010A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer.20360933Monaco ME, Creighton CJ, Lee P, Zou X, Topham MK, Stafforini DMTranslational oncologyExpression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity. Transl Oncol. 2010 Apr; 3(2):91-8.Transl Oncol2010-04-01T00:00:002010Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity.20130264Franco HL, Lee KY, Rubel CA, Creighton CJ, White LD, Broaddus RR, Lewis MT, Lydon JP, Jeong JW, DeMayo FJBiology of reproductionConstitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse. Biol Reprod. 2010 May; 82(5):991-9.Biol Reprod2010-02-03T00:00:002010Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse.20179198Creighton CJ, Fountain MD, Yu Z, Nagaraja AK, Zhu H, Khan M, Olokpa E, Zariff A, Gunaratne PH, Matzuk MM, Anderson MLCancer researchMolecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers. Cancer Res. 2010 Mar 01; 70(5):1906-15.Cancer Res2010-02-23T00:00:002010Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers.20501844Pond AC, Herschkowitz JI, Schwertfeger KL, Welm B, Zhang Y, York B, Cardiff RD, Hilsenbeck S, Perou CM, Creighton CJ, Lloyd RE, Rosen JMCancer researchFibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer. Cancer Res. 2010 Jun 15; 70(12):4868-79.Cancer Res2010-05-25T00:00:002010Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer.20224791Creighton CJ, Benham AL, Zhu H, Khan MF, Reid JG, Nagaraja AK, Fountain MD, Dziadek O, Han D, Ma L, Kim J, Hawkins SM, Anderson ML, Matzuk MM, Gunaratne PHPloS oneDiscovery of novel microRNAs in female reproductive tract using next generation sequencing. PLoS One. 2010 Mar 10; 5(3):e9637.PLoS One2010-03-10T00:00:002010Discovery of novel microRNAs in female reproductive tract using next generation sequencing.20630862Polikepahad S, Knight JM, Naghavi AO, Oplt T, Creighton CJ, Shaw C, Benham AL, Kim J, Soibam B, Harris RA, Coarfa C, Zariff A, Milosavljevic A, Batts LM, Kheradmand F, Gunaratne PH, Corry DBThe Journal of biological chemistryProinflammatory role for let-7 microRNAS in experimental asthma. J Biol Chem. 2010 Sep 24; 285(39):30139-49.J Biol Chem2010-07-14T00:00:002010Proinflammatory role for let-7 microRNAS in experimental asthma.20827542Gunaratne PH, Creighton CJ, Watson M, Tennakoon JBMethods in molecular biology (Clifton, N.J.)Large-scale integration of MicroRNA and gene expression data for identification of enriched microRNA-mRNA associations in biological systems. Methods Mol Biol. 2010; 667:297-315.Methods Mol Biol2010-01-01T00:00:002010Large-scale integration of MicroRNA and gene expression data for identification of enriched microRNA-mRNA associations in biological systems.20962848Su X, Chakravarti D, Cho MS, Liu L, Gi YJ, Lin YL, Leung ML, El-Naggar A, Creighton CJ, Suraokar MB, Wistuba I, Flores ERNatureTAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature. 2010 Oct 21; 467(7318):986-90.Nature2010-10-21T00:00:002010TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs.20964603Creighton CJExpert review of molecular diagnosticsInaugural Genomics Automation Congress and the coming deluge of sequencing data. Expert Rev Mol Diagn. 2010 Oct; 10(7):849-51.Expert Rev Mol Diagn2010-10-01T00:00:002010Inaugural Genomics Automation Congress and the coming deluge of sequencing data.Authorship 7021841628166219John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen BNature neuroscienceIdentification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar; 20(3):396-405.Nat Neurosci2017-02-06T00:00:002017Identification of diverse astrocyte populations and their malignant analogs.21448452Vareed SK, Bhat VB, Thompson C, Vasu VT, Fermin D, Choi H, Creighton CJ, Gayatri S, Lan L, Putluri N, Thangjam GS, Kaur P, Shabahang M, Giri JG, Nesvizhskii AI, Asea AA, Cashikar AG, Rao A, McLoughlin J, Sreekumar APloS oneMetabolites of purine nucleoside phosphorylase (NP) in serum have the potential to delineate pancreatic adenocarcinoma. PLoS One. 2011 Mar 23; 6(3):e17177.PLoS One2011-03-23T00:00:002011Metabolites of purine nucleoside phosphorylase (NP) in serum have the potential to delineate pancreatic adenocarcinoma.21789170Putluri N, Shojaie A, Vasu VT, Nalluri S, Vareed SK, Putluri V, Vivekanandan-Giri A, Byun J, Pennathur S, Sana TR, Fischer SM, Palapattu GS, Creighton CJ, Michailidis G, Sreekumar APloS oneMetabolomic profiling reveals a role for androgen in activating amino acid metabolism and methylation in prostate cancer cells. PLoS One. 2011; 6(7):e21417.PLoS One2011-07-18T00:00:002011Metabolomic profiling reveals a role for androgen in activating amino acid metabolism and methylation in prostate cancer cells.21896780Ahn YH, Yang Y, Gibbons DL, Creighton CJ, Yang F, Wistuba II, Lin W, Thilaganathan N, Alvarez CA, Roybal J, Goldsmith EJ, Tournier C, Kurie JMMolecular and cellular biologyMap2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor ?2 expression. Mol Cell Biol. 2011 Nov; 31(21):4270-85.Mol Cell Biol2011-09-06T00:00:002011Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor ?2 expression.20890303Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang ECOncogeneInt6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium. Oncogene. 2011 Feb 10; 30(6):724-36.Oncogene2010-10-04T00:00:002010Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium.21987723Schliekelman MJ, Gibbons DL, Faca VM, Creighton CJ, Rizvi ZH, Zhang Q, Wong CH, Wang H, Ungewiss C, Ahn YH, Shin DH, Kurie JM, Hanash SMCancer researchTargets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancer. Cancer Res. 2011 Dec 15; 71(24):7670-82.Cancer Res2011-10-10T00:00:002011Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancer.Authorship 7565028Authorship 7565731222331912Kim J, Coffey DM, Creighton CJ, Yu Z, Hawkins SM, Matzuk MMProceedings of the National Academy of Sciences of the United States of AmericaHigh-grade serous ovarian cancer arises from fallopian tube in a mouse model. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3921-6.Proc Natl Acad Sci U S A2012-02-13T00:00:002012High-grade serous ovarian cancer arises from fallopian tube in a mouse model.28052036Zeng H, Ortiz A, Shen PF, Cheng CJ, Lee YC, Yu G, Lin SC, Creighton CJ, Yu-Lee LY, Lin SHOncotargetAngiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway. Oncotarget. 2017 Feb 07; 8(6):10145-10160.Oncotarget2017-02-07T00:00:002017Angiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway.27578002Zhang L, Wang J, Wang Y, Zhang Y, Castro P, Shao L, Sreekumar A, Putluri N, Guha N, Deepak S, Padmanaban A, Creighton CJ, Ittmann MCancer researchMNX1 Is Oncogenically Upregulated in African-American Prostate Cancer. Cancer Res. 2016 11 01; 76(21):6290-6298.Cancer Res2016-08-30T00:00:002016MNX1 Is Oncogenically Upregulated in African-American Prostate Cancer.21177763Litzenburger BC, Creighton CJ, Tsimelzon A, Chan BT, Hilsenbeck SG, Wang T, Carboni JM, Gottardis MM, Huang F, Chang JC, Lewis MT, Rimawi MF, Lee AVClinical cancer research : an official journal of the American Association for Cancer ResearchHigh IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy. Clin Cancer Res. 2011 Apr 15; 17(8):2314-27.Clin Cancer Res2010-12-22T00:00:002010High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy.22576469Xu J, Wan M, He Q, Bassett RL, Fu X, Chen AC, Shi F, Creighton CJ, Schiff R, Huo L, Liu DBreast cancer research and treatmentSGK3 is associated with estrogen receptor expression in breast cancer. Breast Cancer Res Treat. 2012 Jul; 134(2):531-41.Breast Cancer Res Treat2012-05-11T00:00:002012SGK3 is associated with estrogen receptor expression in breast cancer.22644656Chen AC, Migliaccio I, Rimawi M, Lopez-Tarruella S, Creighton CJ, Massarweh S, Huang C, Wang YC, Batra SK, Gutierrez MC, Osborne CK, Schiff RBreast cancer research and treatmentUpregulation of mucin4 in ER-positive/HER2-overexpressing breast cancer xenografts with acquired resistance to endocrine and HER2-targeted therapies. Breast Cancer Res Treat. 2012 Jul; 134(2):583-93.Breast Cancer Res Treat2012-05-29T00:00:002012Upregulation of mucin4 in ER-positive/HER2-overexpressing breast cancer xenografts with acquired resistance to endocrine and HER2-targeted therapies.21423204Mullany LK, Fan HY, Liu Z, White LD, Marshall A, Gunaratne P, Anderson ML, Creighton CJ, Xin L, Deavers M, Wong KK, Richards JSOncogeneMolecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo. Oncogene. 2011 Aug 11; 30(32):3522-36.Oncogene2011-03-21T00:00:002011Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.Authorship 7843491122798293Hawkins SM, Andreu-Vieyra CV, Kim TH, Jeong JW, Hodgson MC, Chen R, Creighton CJ, Lydon JP, Gunaratne PH, DeMayo FJ, Matzuk MMMolecular endocrinology (Baltimore, Md.)Dysregulation of uterine signaling pathways in progesterone receptor-Cre knockout of dicer. Mol Endocrinol. 2012 Sep; 26(9):1552-66.Mol Endocrinol2012-07-13T00:00:002012Dysregulation of uterine signaling pathways in progesterone receptor-Cre knockout of dicer.25753424Liu J, Cho SN, Akkanti B, Jin N, Mao J, Long W, Chen T, Zhang Y, Tang X, Wistub II, Creighton CJ, Kheradmand F, DeMayo FJCell reportsErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis. Cell Rep. 2015 Mar 10; 10(9):1599-1613.Cell Rep2015-03-05T00:00:002015ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis.21532625Bu W, Chen J, Morrison GD, Huang S, Creighton CJ, Huang J, Chamness GC, Hilsenbeck SG, Roop DR, Leavitt AD, Li YOncogeneKeratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. Oncogene. 2011 Oct 27; 30(43):4399-409.Oncogene2011-05-02T00:00:002011Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer.23236152Weng MT, Lee JH, Wei SC, Li Q, Shahamatdar S, Hsu D, Schetter AJ, Swatkoski S, Mannan P, Garfield S, Gucek M, Kim MK, Annunziata CM, Creighton CJ, Emanuele MJ, Harris CC, Sheu JC, Giaccone G, Luo JProceedings of the National Academy of Sciences of the United States of AmericaEvolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):E3659-67.Proc Natl Acad Sci U S A2012-12-10T00:00:002012Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.23434321Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, Creighton CJ, Bolshakov S, McKay RM, Lev D, Le LQ, Parada LFCellCXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors. Cell. 2013 Feb 28; 152(5):1077-90.Cell2013-02-21T00:00:002013CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors.22069192Dong J, Huang S, Caikovski M, Ji S, McGrath A, Custorio MG, Creighton CJ, Maliakkal P, Bogoslovskaia E, Du Z, Zhang X, Lewis MT, Sablitzky F, Brisken C, Li YDevelopment (Cambridge, England)ID4 regulates mammary gland development by suppressing p38MAPK activity. Development. 2011 Dec; 138(23):5247-56.Development2011-12-01T00:00:002011ID4 regulates mammary gland development by suppressing p38MAPK activity.Authorship 840630422350414Zhang P, Bill K, Liu J, Young E, Peng T, Bolshakov S, Hoffman A, Song Y, Demicco EG, Terrada DL, Creighton CJ, Anderson ML, Lazar AJ, Calin GG, Pollock RE, Lev DCancer researchMiR-155 is a liposarcoma oncogene that targets casein kinase-1a and enhances ?-catenin signaling. Cancer Res. 2012 Apr 01; 72(7):1751-62.Cancer Res2012-02-20T00:00:002012MiR-155 is a liposarcoma oncogene that targets casein kinase-1a and enhances ?-catenin signaling.22407831Ghadimi MP, Young ED, Belousov R, Zhang Y, Lopez G, Lusby K, Kivlin C, Demicco EG, Creighton CJ, Lazar AJ, Pollock RE, Lev DClinical cancer research : an official journal of the American Association for Cancer ResearchSurvivin is a viable target for the treatment of malignant peripheral nerve sheath tumors. Clin Cancer Res. 2012 May 01; 18(9):2545-57.Clin Cancer Res2012-03-08T00:00:002012Survivin is a viable target for the treatment of malignant peripheral nerve sheath tumors.28203817Wetendorf M, Wu SP, Wang X, Creighton CJ, Wang T, Lanz RB, Blok L, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJBiology of reproductionDecreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment. Biol Reprod. 2017 02 01; 96(2):313-326.Biol Reprod2017-02-01T00:00:002017Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment.22821997Brewer Savannah KJ, Demicco EG, Lusby K, Ghadimi MP, Belousov R, Young E, Zhang Y, Huang KL, Lazar AJ, Hunt KK, Pollock RE, Creighton CJ, Anderson ML, Lev DClinical cancer research : an official journal of the American Association for Cancer ResearchDual targeting of mTOR and aurora-A kinase for the treatment of uterine Leiomyosarcoma. Clin Cancer Res. 2012 Sep 01; 18(17):4633-45.Clin Cancer Res2012-07-20T00:00:002012Dual targeting of mTOR and aurora-A kinase for the treatment of uterine Leiomyosarcoma.22899370Donehower LA, Creighton CJ, Schultz N, Shinbrot E, Chang K, Gunaratne PH, Muzny D, Sander C, Hamilton SR, Gibbs RA, Wheeler DThe Journal of pathologyMLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes. J Pathol. 2013 Jan; 229(1):99-110.J Pathol2013-01-01T00:00:002013MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.23201680Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, Ittmann MM, Tsai SJ, Tsai MJ, Tsai SYNatureCOUP-TFII inhibits TGF-?-induced growth barrier to promote prostate tumorigenesis. Nature. 2013 Jan 10; 493(7431):236-40.Nature2012-11-28T00:00:002012COUP-TFII inhibits TGF-?-induced growth barrier to promote prostate tumorigenesis.23430223Wander SA, Zhao D, Besser AH, Hong F, Wei J, Ince TA, Milikowski C, Bishopric NH, Minn AJ, Creighton CJ, Slingerland JMBreast cancer research and treatmentPI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy. Breast Cancer Res Treat. 2013 Apr; 138(2):369-81.Breast Cancer Res Treat2013-02-21T00:00:002013PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy.Authorship 8685871928329682Nargund AM, Pham CG, Dong Y, Wang PI, Osmangeyoglu HU, Xie Y, Aras O, Han S, Oyama T, Takeda S, Ray CE, Dong Z, Berge M, Hakimi AA, Monette S, Lekaye CL, Koutcher JA, Leslie CS, Creighton CJ, Weinhold N, Lee W, Tickoo SK, Wang Z, Cheng EH, Hsieh JJCell reportsThe SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma. Cell Rep. 2017 03 21; 18(12):2893-2906.Cell Rep2017-03-21T00:00:002017The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma.28433771Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Lu Y, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang FNeoplasia (New York, N.Y.)A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis. Neoplasia. 2017 May; 19(5):421-428.Neoplasia2017-04-20T00:00:002017A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis.Authorship 8695226Authorship 8696921228512244Lu H, Villafane N, Dogruluk T, Grzeskowiak CL, Kong K, Tsang YH, Zagorodna O, Pantazi A, Yang L, Neill NJ, Kim YW, Creighton CJ, Verhaak RG, Mills GB, Park PJ, Kucherlapati R, Scott KLCancer researchEngineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer. Cancer Res. 2017 07 01; 77(13):3502-3512.Cancer Res2017-05-16T00:00:002017Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer.Authorship 8700644228528867Zhang Y, Kwok-Shing Ng P, Kucherlapati M, Chen F, Liu Y, Tsang YH, de Velasco G, Jeong KJ, Akbani R, Hadjipanayis A, Pantazi A, Bristow CA, Lee E, Mahadeshwar HS, Tang J, Zhang J, Yang L, Seth S, Lee S, Ren X, Song X, Sun H, Seidman J, Luquette LJ, Xi R, Chin L, Protopopov A, Westbrook TF, Shelley CS, Choueiri TK, Ittmann M, Van Waes C, Weinstein JN, Liang H, Henske EP, Godwin AK, Park PJ, Kucherlapati R, Scott KL, Mills GB, Kwiatkowski DJ, Creighton CJCancer cellA Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations. Cancer Cell. 2017 06 12; 31(6):820-832.e3.Cancer Cell2017-05-18T00:00:002017A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.Authorship 872493328588009Casadei L, Calore F, Creighton CJ, Guescini M, Batte K, Iwenofu OH, Zewdu A, Braggio DA, Bill KL, Fadda P, Lovat F, Lopez G, Gasparini P, Chen JL, Kladney RD, Leone G, Lev D, Croce CM, Pollock RECancer researchExosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression. Cancer Res. 2017 07 15; 77(14):3846-3856.Cancer Res2017-06-06T00:00:002017Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression.Authorship 87278022Authorship 872898828611045Wang Y, Wang J, Zhang L, Karatas OF, Shao L, Zhang Y, Castro P, Creighton CJ, Ittmann MCancer researchRGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression. Cancer Res. 2017 08 15; 77(16):4247-4257.Cancer Res2017-06-13T00:00:002017RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression.28614790Casuscelli J, Weinhold N, Gundem G, Wang L, Zabor EC, Drill E, Wang PI, Nanjangud GJ, Redzematovic A, Nargund AM, Manley BJ, Arcila ME, Donin NM, Cheville JC, Thompson RH, Pantuck AJ, Russo P, Cheng EH, Lee W, Tickoo SK, Ostrovnaya I, Creighton CJ, Papaemmanuil E, Seshan VE, Hakimi AA, Hsieh JJJCI insightGenomic landscape and evolution of metastatic chromophobe renal cell carcinoma. JCI Insight. 2017 Jun 15; 2(12).JCI Insight2017-06-15T00:00:002017Genomic landscape and evolution of metastatic chromophobe renal cell carcinoma.Authorship 873080428637297Delaney MA, Wan YW, Kim GE, Creighton CJ, Taylor MG, Masand R, Park A, Valdes C, Gibbons W, Liu Z, Anderson MLThe Journal of clinical endocrinology and metabolismA Role for Progesterone-Regulated sFRP4 Expression in Uterine Leiomyomas. J Clin Endocrinol Metab. 2017 09 01; 102(9):3316-3326.J Clin Endocrinol Metab2017-09-01T00:00:002017A Role for Progesterone-Regulated sFRP4 Expression in Uterine Leiomyomas.28650466Roarty K, Pfefferle AD, Creighton CJ, Perou CM, Rosen JMOncogeneRor2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression. Oncogene. 2017 10 26; 36(43):5958-5968.Oncogene2017-06-26T00:00:002017Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression.Authorship 8746053Authorship 103317312499296Creighton C, Hanash SBioinformatics (Oxford, England)Mining gene expression databases for association rules. Bioinformatics. 2003 Jan; 19(1):79-86.Bioinformatics2003-01-01T00:00:002003Mining gene expression databases for association rules.12681502Creighton C, Hanash S, Beer DFEBS lettersGene expression patterns define pathways correlated with loss of differentiation in lung adenocarcinomas. FEBS Lett. 2003 Apr 10; 540(1-3):167-70.FEBS Lett2003-04-10T00:00:002003Gene expression patterns define pathways correlated with loss of differentiation in lung adenocarcinomas.Authorship 876032528710314Wang Z, Kim TB, Peng B, Karam J, Creighton C, Joon A, Kawakami F, Trevisan P, Jonasch E, Chow CW, Canales JR, Tamboli P, Tannir N, Wood C, Monzon F, Baggerly K, Varella-Garcia M, Czerniak B, Wistuba I, Mills G, Shaw K, Chen K, Sircar KClinical cancer research : an official journal of the American Association for Cancer ResearchSarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape. Clin Cancer Res. 2017 Nov 01; 23(21):6686-6696.Clin Cancer Res2017-07-14T00:00:002017Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape.Authorship 876372228744021Schliekelman MJ, Creighton CJ, Baird BN, Chen Y, Banerjee P, Bota-Rabassedas N, Ahn YH, Roybal JD, Chen F, Zhang Y, Mishra DK, Kim MP, Liu X, Mino B, Villalobos P, Rodriguez-Canales J, Behrens C, Wistuba II, Hanash SM, Kurie JMScientific reportsThy-1+ Cancer-associated Fibroblasts Adversely Impact Lung Cancer Prognosis. Sci Rep. 2017 07 25; 7(1):6478.Sci Rep2017-07-25T00:00:002017Thy-1+ Cancer-associated Fibroblasts Adversely Impact Lung Cancer Prognosis.28775315Chen F, Zhang Y, Boss? D, Lalani AA, Hakimi AA, Hsieh JJ, Choueiri TK, Gibbons DL, Ittmann M, Creighton CJNature communicationsPan-urologic cancer genomic subtypes that transcend tissue of origin. Nat Commun. 2017 08 04; 8(1):199.Nat Commun2017-08-04T00:00:002017Pan-urologic cancer genomic subtypes that transcend tissue of origin.Authorship 876684918030354Choi K, Creighton CJ, Stivers D, Fujimoto N, Kurie JMPloS oneTranscriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations. PLoS One. 2007 Nov 21; 2(11):e1226.PLoS One2007-11-21T00:00:002007Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations.18281487Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Moghaddam S, Evans CM, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton CJ, Demayo FJ, Wistuba II, Kurie JMCancer researchPten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. Cancer Res. 2008 Feb 15; 68(4):1119-27.Cancer Res2008-02-15T00:00:002008Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.18425577Creighton CJ, Kent Osborne C, van de Vijver MJ, Foekens JA, Klijn JG, Horlings HM, Nuyten D, Wang Y, Zhang Y, Chamness GC, Hilsenbeck SG, Lee AV, Schiff RBreast cancer research and treatmentMolecular profiles of progesterone receptor loss in human breast tumors. Breast Cancer Res Treat. 2009 Mar; 114(2):287-99.Breast Cancer Res Treat2008-04-19T00:00:002008Molecular profiles of progesterone receptor loss in human breast tumors.18648548Gu P, Reid JG, Gao X, Shaw CA, Creighton C, Tran PL, Zhou X, Drabek RB, Steffen DL, Hoang DM, Weiss MK, Naghavi AO, El-daye J, Khan MF, Legge GB, Wheeler DA, Gibbs RA, Miller JN, Cooney AJ, Gunaratne PHPloS oneNovel microRNA candidates and miRNA-mRNA pairs in embryonic stem (ES) cells. PLoS One. 2008 Jul 02; 3(7):e2548.PLoS One2008-07-02T00:00:002008Novel microRNA candidates and miRNA-mRNA pairs in embryonic stem (ES) cells.18687774Fernandez-Valdivia R, Mukherjee A, Creighton CJ, Buser AC, DeMayo FJ, Edwards DP, Lydon JPEndocrinologyTranscriptional response of the murine mammary gland to acute progesterone exposure. Endocrinology. 2008 Dec; 149(12):6236-50.Endocrinology2008-08-07T00:00:002008Transcriptional response of the murine mammary gland to acute progesterone exposure.18757440Zhong L, Roybal J, Chaerkady R, Zhang W, Choi K, Alvarez CA, Tran H, Creighton CJ, Yan S, Strieter RM, Pandey A, Kurie JMCancer researchIdentification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment. Cancer Res. 2008 Sep 01; 68(17):7237-45.Cancer Res2008-09-01T00:00:002008Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment.19398556Choi K, Ahn YH, Gibbons DL, Tran HT, Creighton CJ, Girard L, Minna JD, Qin FX, Kurie JMThe Journal of biological chemistryDistinct biological roles for the notch ligands Jagged-1 and Jagged-2. J Biol Chem. 2009 Jun 26; 284(26):17766-74.J Biol Chem2009-04-27T00:00:002009Distinct biological roles for the notch ligands Jagged-1 and Jagged-2.20354771Creighton CJ, Chang JC, Rosen JMJournal of mammary gland biology and neoplasiaEpithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer. J Mammary Gland Biol Neoplasia. 2010 Jun; 15(2):253-60.J Mammary Gland Biol Neoplasia2010-03-31T00:00:002010Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer.20569503Creighton CJ, Fu X, Hennessy BT, Casa AJ, Zhang Y, Gonzalez-Angulo AM, Lluch A, Gray JW, Brown PH, Hilsenbeck SG, Osborne CK, Mills GB, Lee AV, Schiff RBreast cancer research : BCRProteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer. Breast Cancer Res. 2010; 12(3):R40.Breast Cancer Res2010-06-22T00:00:002010Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer.20861284Feng S, Agoulnik IU, Truong A, Li Z, Creighton CJ, Kaftanovskaya EM, Pereira R, Han HD, Lopez-Berestein G, Klonisch T, Ittmann MM, Sood AK, Agoulnik AIEndocrine-related cancerSuppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis. Endocr Relat Cancer. 2010 Dec; 17(4):1021-33.Endocr Relat Cancer2010-10-29T00:00:002010Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis.21115742Roybal JD, Zang Y, Ahn YH, Yang Y, Gibbons DL, Baird BN, Alvarez C, Thilaganathan N, Liu DD, Saintigny P, Heymach JV, Creighton CJ, Kurie JMMolecular cancer research : MCRmiR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1. Mol Cancer Res. 2011 Jan; 9(1):25-35.Mol Cancer Res2010-11-29T00:00:002010miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1.21403400Yang Y, Ahn YH, Gibbons DL, Zang Y, Lin W, Thilaganathan N, Alvarez CA, Moreira DC, Creighton CJ, Gregory PA, Goodall GJ, Kurie JMThe Journal of clinical investigationThe Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. J Clin Invest. 2011 Apr; 121(4):1373-85.J Clin Invest2011-03-14T00:00:002011The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice.21622724Yu W, Feng S, Dakhova O, Creighton CJ, Cai Y, Wang J, Li R, Frolov A, Ayala G, Ittmann MClinical cancer research : an official journal of the American Association for Cancer ResearchFGFR-4 Arg?88 enhances prostate cancer progression via extracellular signal-related kinase and serum response factor signaling. Clin Cancer Res. 2011 Jul 01; 17(13):4355-66.Clin Cancer Res2011-05-27T00:00:002011FGFR-4 Arg?88 enhances prostate cancer progression via extracellular signal-related kinase and serum response factor signaling.21627805Gunaratne PH, Lin YC, Benham AL, Drnevich J, Coarfa C, Tennakoon JB, Creighton CJ, Kim JH, Milosavljevic A, Watson M, Griffiths-Jones S, Clayton DFBMC genomicsSong exposure regulates known and novel microRNAs in the zebra finch auditory forebrain. BMC Genomics. 2011 May 31; 12(1):277.BMC Genomics2011-05-31T00:00:002011Song exposure regulates known and novel microRNAs in the zebra finch auditory forebrain.21750966Creighton CJ, Sada YH, Zhang Y, Tsimelzon A, Wong H, Dave B, Landis MD, Bear HD, Rodriguez A, Chang JCBreast cancer research and treatmentA gene transcription signature of obesity in breast cancer. Breast Cancer Res Treat. 2012 Apr; 132(3):993-1000.Breast Cancer Res Treat2011-07-13T00:00:002011A gene transcription signature of obesity in breast cancer.22140470Batts TD, Machado HL, Zhang Y, Creighton CJ, Li Y, Rosen JMPloS oneStem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration. PLoS One. 2011; 6(11):e27841.PLoS One2011-11-29T00:00:002011Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration.22157079Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TFScience (New York, N.Y.)A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science. 2012 Jan 20; 335(6066):348-53.Science2011-12-08T00:00:002011A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.22479643Creighton CJ, Hernandez-Herrera A, Jacobsen A, Levine DA, Mankoo P, Schultz N, Du Y, Zhang Y, Larsson E, Sheridan R, Xiao W, Spellman PT, Getz G, Wheeler DA, Perou CM, Gibbs RA, Sander C, Hayes DN, Gunaratne PH, Cancer Genome Atlas Research NetworkPloS oneIntegrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma. PLoS One. 2012; 7(3):e34546.PLoS One2012-03-29T00:00:002012Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma.22535157Shan W, Akinfenwa PY, Savannah KB, Kolomeyevskaya N, Laucirica R, Thomas DG, Odunsi K, Creighton CJ, Lev DC, Anderson MLClinical cancer research : an official journal of the American Association for Cancer ResearchA small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma. Clin Cancer Res. 2012 Jun 15; 18(12):3352-65.Clin Cancer Res2012-04-25T00:00:002012A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma.22974392Creighton CJCurrent drug targetsMolecular classification and drug response prediction in cancer. Curr Drug Targets. 2012 Nov; 13(12):1488-94.Curr Drug Targets2012-11-01T00:00:002012Molecular classification and drug response prediction in cancer.29103953Sreekumar A, Toneff MJ, Toh E, Roarty K, Creighton CJ, Belka GK, Lee DK, Xu J, Chodosh LA, Richards JS, Rosen JMDevelopmental cellWNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis. Dev Cell. 2017 11 20; 43(4):436-448.e6.Dev Cell2017-11-02T00:00:002017WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis.29617660Campbell JD, Yau C, Bowlby R, Liu Y, Brennan K, Fan H, Taylor AM, Wang C, Walter V, Akbani R, Byers LA, Creighton CJ, Coarfa C, Shih J, Cherniack AD, Gevaert O, Prunello M, Shen H, Anur P, Chen J, Cheng H, Hayes DN, Bullman S, Pedamallu CS, Ojesina AI, Sadeghi S, Mungall KL, Robertson AG, Benz C, Schultz A, Kanchi RS, Gay CM, Hegde A, Diao L, Wang J, Ma W, Sumazin P, Chiu HS, Chen TW, Gunaratne P, Donehower L, Rader JS, Zuna R, Al-Ahmadie H, Lazar AJ, Flores ER, Tsai KY, Zhou JH, Rustgi AK, Drill E, Shen R, Wong CK, Cancer Genome Atlas Research Network, Stuart JM, Laird PW, Hoadley KA, Weinstein JN, Peto M, Pickering CR, Chen Z, Van Waes CCell reportsGenomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas. Cell Rep. 2018 04 03; 23(1):194-212.e6.Cell Rep2018-04-03T00:00:002018Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.23122291Valdez JM, Zhang L, Su Q, Dakhova O, Zhang Y, Shahi P, Spencer DM, Creighton CJ, Ittmann MM, Xin LCell stem cellNotch and TGF? form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity. Cell Stem Cell. 2012 Nov 02; 11(5):676-88.Cell Stem Cell2012-11-02T00:00:002012Notch and TGF? form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity.Authorship 8791737Authorship 87918710Authorship 8795504Authorship 8798696Authorship 8801508Authorship 8818035Authorship 8820236Authorship 882117123257362Verhaak RG, Tamayo P, Yang JY, Hubbard D, Zhang H, Creighton CJ, Fereday S, Lawrence M, Carter SL, Mermel CH, Kostic AD, Etemadmoghadam D, Saksena G, Cibulskis K, Duraisamy S, Levanon K, Sougnez C, Tsherniak A, Gomez S, Onofrio R, Gabriel S, Chin L, Zhang N, Spellman PT, Zhang Y, Akbani R, Hoadley KA, Kahn A, K?bel M, Huntsman D, Soslow RA, Defazio A, Birrer MJ, Gray JW, Weinstein JN, Bowtell DD, Drapkin R, Mesirov JP, Getz G, Levine DA, Meyerson M, Cancer Genome Atlas Research NetworkThe Journal of clinical investigationPrognostically relevant gene signatures of high-grade serous ovarian carcinoma. J Clin Invest. 2013 Jan; 123(1):517-25.J Clin Invest2012-12-21T00:00:002012Prognostically relevant gene signatures of high-grade serous ovarian carcinoma.Authorship 8824449Authorship 88266217Authorship 88277414Authorship 88294012Authorship 8831147Authorship 8835507Authorship 8840655Authorship 8840816Authorship 88417511Authorship 8842665Authorship 88461717Authorship 8851701729653981You R, DeMayo FJ, Liu J, Cho SN, Burt BM, Creighton CJ, Casal RF, Lazarus DR, Lu W, Tung HY, Yuan X, Hill-McAlester A, Kim M, Perusich S, Cornwell L, Rosen D, Song LZ, Paust S, Diehl G, Corry D, Kheradmand FCancer immunology researchIL17A Regulates Tumor Latency and Metastasis in Lung Adeno and Squamous SQ.2b and AD.1 Cancer. Cancer Immunol Res. 2018 06; 6(6):645-657.Cancer Immunol Res2018-04-13T00:00:002018IL17A Regulates Tumor Latency and Metastasis in Lung Adeno and Squamous SQ.2b and AD.1 Cancer.28947967Karatas OF, Wang J, Shao L, Ozen M, Zhang Y, Creighton CJ, Ittmann MOncotargetmiR-33a is a tumor suppressor microRNA that is decreased in prostate cancer. Oncotarget. 2017 Sep 01; 8(36):60243-60256.Oncotarget2017-07-24T00:00:002017miR-33a is a tumor suppressor microRNA that is decreased in prostate cancer.29053101Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK, Deneen BeLifeDaam2 driven degradation of VHL promotes gliomagenesis. Elife. 2017 10 20; 6.Elife2017-10-20T00:00:002017Daam2 driven degradation of VHL promotes gliomagenesis.29535300Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang FF, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JTNature communicationsAtrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun. 2018 03 13; 9(1):1057.Nat Commun2018-03-13T00:00:002018Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling.29131367Coarfa C, Florentin D, Putluri N, Ding Y, Au J, He D, Ragheb A, Frolov A, Michailidis G, Lee M, Kadmon D, Miles B, Smith C, Ittmann M, Rowley D, Sreekumar A, Creighton CJ, Ayala GThe ProstateInfluence of the neural microenvironment on prostate cancer. Prostate. 2018 Feb; 78(2):128-139.Prostate2017-11-13T00:00:002017Influence of the neural microenvironment on prostate cancer.29266437Hsieh JJ, Le V, Cao D, Cheng EH, Creighton CJThe Journal of pathologyGenomic classifications of renal cell carcinoma: a critical step towards the future application of personalized kidney cancer care with pan-omics precision. J Pathol. 2018 04; 244(5):525-537.J Pathol2018-02-14T00:00:002018Genomic classifications of renal cell carcinoma: a critical step towards the future application of personalized kidney cancer care with pan-omics precision.29396322Reznik E, Luna A, Aksoy BA, Liu EM, La K, Ostrovnaya I, Creighton CJ, Hakimi AA, Sander CCell systemsA Landscape of Metabolic Variation across Tumor Types. Cell Syst. 2018 Mar 28; 6(3):301-313.e3.Cell Syst2018-01-27T00:00:002018A Landscape of Metabolic Variation across Tumor Types.29514796Yu-Lee LY, Yu G, Lee YC, Lin SC, Pan J, Pan T, Yu KJ, Liu B, Creighton CJ, Rodriguez-Canales J, Villalobos PA, Wistuba II, de Nadal E, Posas F, Gallick GE, Lin SHCancer researchOsteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGF?RIII-p38MAPK-pS249/T252RB Pathway. Cancer Res. 2018 06 01; 78(11):2911-2924.Cancer Res2018-03-07T00:00:002018Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGF?RIII-p38MAPK-pS249/T252RB Pathway.28881599Carron EC, Homra S, Rosenberg J, Coffelt SB, Kittrell F, Zhang Y, Creighton CJ, Fuqua SA, Medina D, Machado HLOncotargetMacrophages promote the progression of premalignant mammary lesions to invasive cancer. Oncotarget. 2017 Aug 01; 8(31):50731-50746.Oncotarget2017-01-31T00:00:002017Macrophages promote the progression of premalignant mammary lesions to invasive cancer.28892058Glasgow SM, Carlson JC, Zhu W, Chaboub LS, Kang P, Lee HK, Clovis YM, Lozzi BE, McEvilly RJ, Rosenfeld MG, Creighton CJ, Lee SK, Mohila CA, Deneen BNature neuroscienceGlia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nat Neurosci. 2017 Nov; 20(11):1520-1528.Nat Neurosci2017-09-11T00:00:002017Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis.29229606El-Shennawy L, Dubrovskyi O, Kastrati I, Danes JM, Zhang Y, Whiteley HE, Creighton CJ, Frasor JCancer researchCoactivation of Estrogen Receptor and IKK? Induces a Dormant Metastatic Phenotype in ER-Positive Breast Cancer. Cancer Res. 2018 02 15; 78(4):974-984.Cancer Res2017-12-11T00:00:002017Coactivation of Estrogen Receptor and IKK? Induces a Dormant Metastatic Phenotype in ER-Positive Breast Cancer.29324442Tan X, Banerjee P, Liu X, Yu J, Gibbons DL, Wu P, Scott KL, Diao L, Zheng X, Wang J, Jalali A, Suraokar M, Fujimoto J, Behrens C, Liu X, Liu CG, Creighton CJ, Wistuba II, Kurie JMThe Journal of clinical investigationThe epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network. J Clin Invest. 2018 04 02; 128(4):1267-1282.J Clin Invest2018-02-26T00:00:002018The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network.29337373Creighton CJCurrent protocols in molecular biologyMaking Use of Cancer Genomic Databases. Curr Protoc Mol Biol. 2018 01 16; 121:19.14.1-19.14.13.Curr Protoc Mol Biol2018-01-16T00:00:002018Making Use of Cancer Genomic Databases.29353553Lalani AA, Xie W, Martini DJ, Steinharter JA, Norton CK, Krajewski KM, Duquette A, Boss? D, Bellmunt J, Van Allen EM, McGregor BA, Creighton CJ, Harshman LC, Choueiri TKJournal for immunotherapy of cancerChange in Neutrophil-to-lymphocyte ratio (NLR) in response to immune checkpoint blockade for metastatic renal cell carcinoma. J Immunother Cancer. 2018 01 22; 6(1):5.J Immunother Cancer2018-01-22T00:00:002018Change in Neutrophil-to-lymphocyte ratio (NLR) in response to immune checkpoint blockade for metastatic renal cell carcinoma.29440175Chen F, Zhang Y, Gibbons DL, Deneen B, Kwiatkowski DJ, Ittmann M, Creighton CJClinical cancer research : an official journal of the American Association for Cancer ResearchPan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases. Clin Cancer Res. 2018 05 01; 24(9):2182-2193.Clin Cancer Res2018-02-09T00:00:002018Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases.29574636Bhat RR, Yadav P, Sahay D, Bhargava DK, Creighton CJ, Yazdanfard S, Al-Rawi A, Yadav V, Qin L, Nanda S, Sethunath V, Fu X, De Angelis C, Narkar VA, Osborne CK, Schiff R, Trivedi MVBreast cancer research and treatmentGPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer. Breast Cancer Res Treat. 2018 Jul; 170(2):279-292.Breast Cancer Res Treat2018-03-24T00:00:002018GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer.29578538Nair A, Chung HC, Sun T, Tyagi S, Dobrolecki LE, Dominguez-Vidana R, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Schmitt E, Chan DW, Li H, Mao S, Petrovic I, Creighton CJ, Gutierrez C, Dubrulle J, Stossi F, Tyner JW, Lichtarge O, Lin CY, Zhang B, Scott KL, Hilsenbeck SG, Sun J, Yu X, Osborne CK, Schiff R, Christensen JG, Shields DJ, Rimawi MF, Ellis MJ, Shaw CA, Lewis MT, Westbrook TFNature medicineCombinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer. Nat Med. 2018 05; 24(4):505-511.Nat Med2018-03-26T00:00:002018Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer.29581856Shao L, Wang J, Karatas OF, Feng S, Zhang Y, Creighton CJ, Ittmann MOncotargetFibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2/ERG fusion gene and decreased PTEN. Oncotarget. 2018 Mar 06; 9(18):14456-14471.Oncotarget2018-02-12T00:00:002018Fibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2/ERG fusion gene and decreased PTEN.23334251Lusby K, Savannah KB, Demicco EG, Zhang Y, Ghadimi MP, Young ED, Colombo C, Lam R, Dogan TE, Hornick JL, Lazar AJ, Hunt KK, Anderson ML, Creighton CJ, Lev D, Pollock REAnnals of surgical oncologyUterine leiomyosarcoma management, outcome, and associated molecular biomarkers: a single institution's experience. Ann Surg Oncol. 2013 Jul; 20(7):2364-72.Ann Surg Oncol2013-01-20T00:00:002013Uterine leiomyosarcoma management, outcome, and associated molecular biomarkers: a single institution's experience.23454583Mach CM, Kim J, Soibam B, Creighton CJ, Hawkins SM, Zighelboim I, Goodfellow P, Gunaratne PH, Odunsi K, Salem PA, Anderson MLCancer lettersNovel MicroRNAs regulating proliferation and apoptosis in uterine papillary serous carcinomas. Cancer Lett. 2013 Jul 28; 335(2):314-22.Cancer Lett2013-02-26T00:00:002013Novel MicroRNAs regulating proliferation and apoptosis in uterine papillary serous carcinomas.23671572Kaipparettu BA, Ma Y, Park JH, Lee TL, Zhang Y, Yotnda P, Creighton CJ, Chan WY, Wong LJPloS oneCrosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways. PLoS One. 2013; 8(5):e61747.PLoS One2013-05-09T00:00:002013Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways.true1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessorAuthorship 1060183D020869Procedures125051650.411295Gene Expression ProfilingD023281Occupations82327260.446077GenomicsD015972Physiology125688690.314255Gene Expression Regulation, Neoplastic30401712Bu W, Liu Z, Jiang W, Nagi C, Huang S, Edwards DP, Jo E, Mo Q, Creighton CJ, Hilsenbeck SG, Leavitt AD, Lewis MT, Wong STC, Li YCancer researchMammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes. Cancer Res. 2019 01 01; 79(1):61-71.Cancer Res2018-11-06T00:00:002018Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes.Authorship 1080073Authorship 1047718Authorship 9137874Authorship 91676125Authorship 9232408Authorship 9299558Authorship 93051436Authorship 9311735Authorship 93260217D035683Chemicals & Drugs75129430.373492MicroRNAsAuthorship 9334266Authorship 9338392Authorship 93403619Authorship 9341329Authorship 9342431Authorship 9349683Authorship 9361494Authorship 9373054Authorship 938741428723366Lerner SP, Weinstein J, Kwiatkowski D, Kim J, Robertson G, Hoadley KA, Akbani R, Creighton C, TCGA Muscle Invasive Bladder Cancer Analysis Working GroupEuropean urology focusThe Cancer Genome Atlas Project on Muscle-invasive Bladder Cancer. Eur Urol Focus. 2015 Aug; 1(1):94-95.Eur Urol Focus2015-06-06T00:00:002015The Cancer Genome Atlas Project on Muscle-invasive Bladder Cancer.28732212Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK, Varambally SNeoplasia (New York, N.Y.)UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses. Neoplasia. 2017 Aug; 19(8):649-658.Neoplasia2017-07-18T00:00:002017UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses.29590203Palaniappan M, Edwards D, Creighton CJ, Medina D, Conneely OMPloS oneReprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells. PLoS One. 2018; 13(3):e0194913.PLoS One2018-03-28T00:00:002018Reprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells.29858753Reddy JP, Atkinson RL, Larson R, Burks JK, Smith D, Debeb BG, Ruffell B, Creighton CJ, Bambhroliya A, Reuben JM, Van Laere SJ, Krishnamurthy S, Symmans WF, Brewster AM, Woodward WABreast cancer research and treatmentMammary stem cell and macrophage markers are enriched in normal tissue adjacent to inflammatory breast cancer. Breast Cancer Res Treat. 2018 Sep; 171(2):283-293.Breast Cancer Res Treat2018-06-01T00:00:002018Mammary stem cell and macrophage markers are enriched in normal tissue adjacent to inflammatory breast cancer.30081681Creighton CJExpert review of anticancer therapyThe clinical applications of The Cancer Genome Atlas project for bladder cancer. Expert Rev Anticancer Ther. 2018 10; 18(10):973-980.Expert Rev Anticancer Ther2018-08-13T00:00:002018The clinical applications of The Cancer Genome Atlas project for bladder cancer.29996110Zhang Y, Yang L, Kucherlapati M, Chen F, Hadjipanayis A, Pantazi A, Bristow CA, Lee EA, Mahadeshwar HS, Tang J, Zhang J, Seth S, Lee S, Ren X, Song X, Sun H, Seidman J, Luquette LJ, Xi R, Chin L, Protopopov A, Li W, Park PJ, Kucherlapati R, Creighton CJCell reportsA Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases. Cell Rep. 2018 07 10; 24(2):515-527.Cell Rep2018-07-10T00:00:002018A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases.30267595Lu Y, Cao J, Napoli M, Xia Z, Zhao N, Creighton CJ, Li W, Chen X, Flores ER, McManus MT, Rosen JMStem cells (Dayton, Ohio)miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution. Stem Cells. 2018 12; 36(12):1875-1889.Stem Cells2018-10-31T00:00:002018miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution.30332658Classe M, Yao H, Mouawad R, Creighton CJ, Burgess A, Allanic F, Wassef M, Leroy X, Verillaud B, Mortuaire G, Bielle F, Le Tourneau C, Kurtz JE, Khayat D, Su X, Malouf GGCell reportsIntegrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny. Cell Rep. 2018 10 16; 25(3):811-821.e5.Cell Rep2018-10-16T00:00:002018Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny.30401717Chen F, Zhang Y, Varambally S, Creighton CJMolecular cancer research : MCRMolecular Correlates of Metastasis by Systematic Pan-Cancer Analysis Across The Cancer Genome Atlas. Mol Cancer Res. 2019 02; 17(2):476-487.Mol Cancer Res2018-11-06T00:00:002018Molecular Correlates of Metastasis by Systematic Pan-Cancer Analysis Across The Cancer Genome Atlas.30108197Tan X, Banerjee P, Liu X, Yu J, Gibbons DL, Wu P, Scott KL, Diao L, Zheng X, Wang J, Jalali A, Suraokar M, Fujimoto J, Behrens C, Liu X, Liu CG, Creighton CJ, Wistuba II, Kurie JMThe Journal of clinical investigationThe epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network. J Clin Invest. 2018 07 02; 128(7):3198.J Clin Invest2018-07-02T00:00:002018The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network.30345533Suer I, Guzel E, Karatas OF, Creighton CJ, Ittmann M, Ozen MThe ProstateMicroRNAs as prognostic markers in prostate cancer. Prostate. 2019 02; 79(3):265-271.Prostate2018-10-21T00:00:002018MicroRNAs as prognostic markers in prostate cancer.30089255Lei JT, Shao J, Zhang J, Iglesia M, Chan DW, Cao J, Anurag M, Singh P, He X, Kosaka Y, Matsunuma R, Crowder R, Hoog J, Phommaly C, Goncalves R, Ramalho S, Peres RMR, Punturi N, Schmidt C, Bartram A, Jou E, Devarakonda V, Holloway KR, Lai WV, Hampton O, Rogers A, Tobias E, Parikh PA, Davies SR, Li S, Ma CX, Suman VJ, Hunt KK, Watson MA, Hoadley KA, Thompson EA, Chen X, Kavuri SM, Creighton CJ, Maher CA, Perou CM, Haricharan S, Ellis MJCell reportsFunctional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer. Cell Rep. 2018 08 07; 24(6):1434-1444.e7.Cell Rep2018-08-07T00:00:002018Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer.30651315Kriseman M, Monsivais D, Agno J, Masand RP, Creighton CJ, Matzuk MMProceedings of the National Academy of Sciences of the United States of AmericaUterine double-conditional inactivation of Smad2 and Smad3 in mice causes endometrial dysregulation, infertility, and uterine cancer. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3873-3882.Proc Natl Acad Sci U S A2019-01-16T00:00:002019Uterine double-conditional inactivation of Smad2 and Smad3 in mice causes endometrial dysregulation, infertility, and uterine cancer.30380420Wang Y, Xu X, Maglic D, Dill MT, Mojumdar K, Ng PK, Jeong KJ, Tsang YH, Moreno D, Bhavana VH, Peng X, Ge Z, Chen H, Li J, Chen Z, Zhang H, Han L, Du D, Creighton CJ, Mills GB, Cancer Genome Atlas Research Network, Camargo F, Liang HCell reportsComprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer. Cell Rep. 2018 10 30; 25(5):1304-1317.e5.Cell Rep2018-10-30T00:00:002018Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.30688659Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, Shi Q, Zhou H, Zhang Y, Moore DD, Yang FThe Journal of clinical investigationMAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling. J Clin Invest. 2019 03 01; 129(3):1015-1029.J Clin Invest2019-01-28T00:00:002019MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling.Department of MedicineDepartment of Pathology & ImmunologyDuncan Cancer CenterMedicine-Hematology & OncologyCancer CenterPathologyBaylor College of MedicineRAMMURTIKAMBLERAMMURTI KAMBLE0.000000000000000.0000000000000012KAMBLE, RAMMURTIProfessor4.11240.008277481063research areas4.523810.0204614279coauthor of255.38954.435460similar to11364selected publicationsJULIENANGIAJULIE NANGIA0.000000000000000.000000000000001756NANGIA, JULIEAssociate ProfessorAuthorship 1103653CARLOSRAMOSCARLOS RAMOS0.000000000000000.000000000000002089RAMOS, CARLOSProfessorBINUMICHAELBINU MICHAEL0.000000000000000.000000000000004163MICHAEL, BINUAssistant ProfessorAuthorship 10578113Authorship 942280730878879Kwon OJ, Zhang Y, Li Y, Wei X, Zhang L, Chen R, Creighton CJ, Xin LiScienceFunctional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq. iScience. 2019 Mar 29; 13:328-338.iScience2019-03-02T00:00:002019Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq.MICHAELITTMANNMICHAEL ITTMANN0.000000000000000.000000000000002694ITTMANN, MICHAELProfessorANITASABICHIANITA SABICHI0.000000000000000.000000000000004027SABICHI, ANITAAssistant ProfessorAuthorship 943378930924768Xu J, Reznik E, Lee HJ, Gundem G, Jonsson P, Sarungbam J, Bialik A, Sanchez-Vega F, Creighton CJ, Hoekstra J, Zhang L, Sajjakulnukit P, Kremer D, Tolstyka Z, Casuscelli J, Stirdivant S, Tang J, Schultz N, Jeng P, Dong Y, Su W, Cheng EH, Russo P, Coleman JA, Papaemmanuil E, Chen YB, Reuter VE, Sander C, Kennedy SR, Hsieh JJ, Lyssiotis CA, Tickoo SK, Hakimi AAeLifeAbnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma. Elife. 2019 04 01; 8.Elife2019-04-01T00:00:002019Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma.Authorship 94369817Authorship 943950630013058Grzeskowiak CL, Kundu ST, Mo X, Ivanov AA, Zagorodna O, Lu H, Chapple RH, Tsang YH, Moreno D, Mosqueda M, Eterovic K, Fradette JJ, Ahmad S, Chen F, Chong Z, Chen K, Creighton CJ, Fu H, Mills GB, Gibbons DL, Scott KLNature communicationsIn vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer. Nat Commun. 2018 07 16; 9(1):2732.Nat Commun2018-07-16T00:00:002018In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.30013069Kundu ST, Grzeskowiak CL, Fradette JJ, Gibson LA, Rodriguez LB, Creighton CJ, Scott KL, Gibbons DLNature communicationsTMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins. Nat Commun. 2018 07 16; 9(1):2731.Nat Commun2018-07-16T00:00:002018TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.Authorship 94518814Authorship 9454511030990221Mukhopadhyay UK, Oturkar CC, Adams C, Wickramasekera N, Bansal S, Medisetty R, Miller A, Swetzig WM, Silwal-Pandit L, B?rresen-Dale AL, Creighton CJ, Park JH, Konduri SD, Mukhopadhyay A, Caradori A, Omilian A, Bshara W, Kaipparettu BA, Das GMJournal of the National Cancer InstituteTP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer. J Natl Cancer Inst. 2019 11 01; 111(11):1202-1215.J Natl Cancer Inst2019-11-01T00:00:002019TP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer.30982770Wei X, Zhang L, Zhou Z, Kwon OJ, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo MM, Xu F, Creighton CJ, Ittmann MM, Xin LCell stem cellSpatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms. Cell Stem Cell. 2019 05 02; 24(5):753-768.e6.Cell Stem Cell2019-04-11T00:00:002019Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms.Authorship 946494331068478Monsivais D, Kriseman M, Creighton CJ, Matzuk MMProceedings of the National Academy of Sciences of the United States of AmericaReply to Liu et al.: ALK5-mediated tumor suppressor signaling through SMAD2 and SMAD3 in the uterus. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9166-9167.Proc Natl Acad Sci U S A2019-05-07T00:00:002019Reply to Liu et al.: ALK5-mediated tumor suppressor signaling through SMAD2 and SMAD3 in the uterus.Authorship 1272369Authorship 1272779D059467Concepts & IdeasGenes & Molecular Sequences76218630.524004TranscriptomeAuthorship 1278851Authorship 1281453Authorship 1287971Authorship 1291092Authorship 129111523792563Cancer Genome Atlas Research NetworkNatureComprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 2013 Jul 04; 499(7456):43-9.Nature2013-06-23T00:00:002013Comprehensive molecular characterization of clear cell renal cell carcinoma.23912551Bayrak OF, Gulluoglu S, Aydemir E, Ture U, Acar H, Atalay B, Demir Z, Sevli S, Creighton CJ, Ittmann M, Sahin F, Ozen MJournal of neuro-oncologyMicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas. J Neurooncol. 2013 Nov; 115(2):143-51.J Neurooncol2013-08-03T00:00:002013MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas.23950537Millien VO, Lu W, Shaw J, Yuan X, Mak G, Roberts L, Song LZ, Knight JM, Creighton CJ, Luong A, Kheradmand F, Corry DBScience (New York, N.Y.)Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4. Science. 2013 Aug 16; 341(6147):792-6.Science2013-08-16T00:00:002013Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4.23979845Lain AR, Creighton CJ, Conneely OMMolecular endocrinology (Baltimore, Md.)Research resource: progesterone receptor targetome underlying mammary gland branching morphogenesis. Mol Endocrinol. 2013 Oct; 27(10):1743-61.Mol Endocrinol2013-08-26T00:00:002013Research resource: progesterone receptor targetome underlying mammary gland branching morphogenesis.23980093Abazeed ME, Adams DJ, Hurov KE, Tamayo P, Creighton CJ, Sonkin D, Giacomelli AO, Du C, Fries DF, Wong KK, Mesirov JP, Loeffler JS, Schreiber SL, Hammerman PS, Meyerson MCancer researchIntegrative radiogenomic profiling of squamous cell lung cancer. Cancer Res. 2013 Oct 15; 73(20):6289-98.Cancer Res2013-08-26T00:00:002013Integrative radiogenomic profiling of squamous cell lung cancer.23986650Creighton CJ, Gibbons DL, Kurie JMCancer management and researchThe role of epithelial-mesenchymal transition programming in invasion and metastasis: a clinical perspective. Cancer Manag Res. 2013; 5:187-95.Cancer Manag Res2013-07-31T00:00:002013The role of epithelial-mesenchymal transition programming in invasion and metastasis: a clinical perspective.24071849Cancer Genome Atlas Research Network, Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JMNature geneticsThe Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013 Oct; 45(10):1113-20.Nat Genet2013-10-01T00:00:002013The Cancer Genome Atlas Pan-Cancer analysis project.Authorship 1115102Authorship 947178331089135Liu J, Wang T, Creighton CJ, Wu SP, Ray M, Janardhan KS, Willson CJ, Cho SN, Castro PD, Ittmann MM, Li JL, Davis RJ, DeMayo FJNature communicationsJNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression. Nat Commun. 2019 05 14; 10(1):2148.Nat Commun2019-05-14T00:00:002019JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression.Authorship 1105619Authorship 953593431399646Thakur VS, Aguila B, Brett-Morris A, Creighton CJ, Welford SMOncogeneSpermidine/spermine N1-acetyltransferase 1 is a gene-specific transcriptional regulator that drives brain tumor aggressiveness. Oncogene. 2019 10; 38(41):6794-6800.Oncogene2019-08-09T00:00:002019Spermidine/spermine N1-acetyltransferase 1 is a gene-specific transcriptional regulator that drives brain tumor aggressiveness.31437244Kaipparettu BA, Ma Y, Park JH, Lee TL, Zhang Y, Yotnda P, Creighton CJ, Chan WY, Wong LCPloS oneCorrection: Crosstalk from Non-Cancerous Mitochondria Can Inhibit Tumor Properties of Metastatic Cells by Suppressing Oncogenic Pathways. PLoS One. 2019; 14(8):e0221671.PLoS One2019-08-22T00:00:002019Correction: Crosstalk from Non-Cancerous Mitochondria Can Inhibit Tumor Properties of Metastatic Cells by Suppressing Oncogenic Pathways.Authorship 9552711031503278Fahrmann JF, Vykoukal J, Fleury A, Tripathi S, Dennison JB, Murage E, Wang P, Yu CY, Capello M, Creighton CJ, Do KA, Long JP, Irajizad E, Peterson C, Katayama H, Disis ML, Arun B, Hanash SJournal of the National Cancer InstituteAssociation Between Plasma Diacetylspermine and Tumor Spermine Synthase With Outcome in Triple-Negative Breast Cancer. J Natl Cancer Inst. 2020 06 01; 112(6):607-616.J Natl Cancer Inst2020-06-01T00:00:002020Association Between Plasma Diacetylspermine and Tumor Spermine Synthase With Outcome in Triple-Negative Breast Cancer.Authorship 1113873Authorship 9572002331610796Zhang Y, Yang L, Kucherlapati M, Hadjipanayis A, Pantazi A, Bristow CA, Lee EA, Mahadeshwar HS, Tang J, Zhang J, Seth S, Lee S, Ren X, Song X, Sun H, Seidman J, Luquette LJ, Xi R, Chin L, Protopopov A, Park PJ, Kucherlapati R, Creighton CJGenome biologyGlobal impact of somatic structural variation on the DNA methylome of human cancers. Genome Biol. 2019 10 15; 20(1):209.Genome Biol2019-10-15T00:00:002019Global impact of somatic structural variation on the DNA methylome of human cancers.Authorship 957874731652963Thangavel H, De Angelis C, Vasaikar S, Bhat R, Jolly MK, Nagi C, Creighton CJ, Chen F, Dobrolecki LE, George JT, Kumar T, Abdulkareem NM, Mao S, Nardone A, Rimawi M, Osborne CK, Lewis MT, Levine H, Zhang B, Schiff R, Giuliano M, Trivedi MVJournal of clinical medicineA CTC-Cluster-Specific Signature Derived from OMICS Analysis of Patient-Derived Xenograft Tumors Predicts Outcomes in Basal-Like Breast Cancer. J Clin Med. 2019 10 24; 8(11).J Clin Med2019-10-24T00:00:002019A CTC-Cluster-Specific Signature Derived from OMICS Analysis of Patient-Derived Xenograft Tumors Predicts Outcomes in Basal-Like Breast Cancer.Authorship 9609261731719531Manshouri R, Coyaud E, Kundu ST, Peng DH, Stratton SA, Alton K, Bajaj R, Fradette JJ, Minelli R, Peoples MD, Carugo A, Chen F, Bristow C, Kovacs JJ, Barton MC, Heffernan T, Creighton CJ, Raught B, Gibbons DLNature communicationsZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer. Nat Commun. 2019 11 12; 10(1):5125.Nat Commun2019-11-12T00:00:002019ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer.Authorship 961841131780818Creighton CJNature reviews. NephrologyProteomic signatures of clear cell renal cell carcinoma. Nat Rev Nephrol. 2020 03; 16(3):133-134.Nat Rev Nephrol2020-03-01T00:00:002020Proteomic signatures of clear cell renal cell carcinoma.Authorship 962504431831737Chen F, Chandrashekar DS, Varambally S, Creighton CJNature communicationsPan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers. Nat Commun. 2019 12 12; 10(1):5679.Nat Commun2019-12-12T00:00:002019Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers.Authorship 9762173331969487Tan X, Banerjee P, Pham EA, Rutaganira FUN, Basu K, Bota-Rabassedas N, Guo HF, Grzeskowiak CL, Liu X, Yu J, Shi L, Peng DH, Rodriguez BL, Zhang J, Zheng V, Duose DY, Solis LM, Mino B, Raso MG, Behrens C, Wistuba II, Scott KL, Smith M, Nguyen K, Lam G, Choong I, Mazumdar A, Hill JL, Gibbons DL, Brown PH, Russell WK, Shokat K, Creighton CJ, Glenn JS, Kurie JMScience translational medicinePI4KIII? is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma. Sci Transl Med. 2020 01 22; 12(527).Sci Transl Med2020-01-22T00:00:002020PI4KIII? is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma.Authorship 9766881431996845Yu K, Lin CJ, Hatcher A, Lozzi B, Kong K, Huang-Hobbs E, Cheng YT, Beechar VB, Zhu W, Zhang Y, Chen F, Mills GB, Mohila CA, Creighton CJ, Noebels JL, Scott KL, Deneen BNaturePIK3CA variants selectively initiate brain hyperactivity during gliomagenesis. Nature. 2020 02; 578(7793):166-171.Nature2020-01-29T00:00:002020PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.Authorship 9774536Authorship 9774559Authorship 9774603832024823Zhang Y, Chen F, Fonseca NA, He Y, Fujita M, Nakagawa H, Zhang Z, Brazma A, PCAWG Transcriptome Working Group, PCAWG Structural Variation Working Group, Creighton CJ, PCAWG ConsortiumNature communicationsHigh-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. Nat Commun. 2020 02 05; 11(1):736.Nat Commun2020-02-05T00:00:002020High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.32024997Yuan Y, Ju YS, Kim Y, Li J, Wang Y, Yoon CJ, Yang Y, Martincorena I, Creighton CJ, Weinstein JN, Xu Y, Han L, Kim HL, Nakagawa H, Park K, Campbell PJ, Liang H, PCAWG ConsortiumNature geneticsComprehensive molecular characterization of mitochondrial genomes in human cancers. Nat Genet. 2020 03; 52(3):342-352.Nat Genet2020-02-05T00:00:002020Comprehensive molecular characterization of mitochondrial genomes in human cancers.32025019PCAWG Transcriptome Core Group, Calabrese C, Davidson NR, Demircioglu D, Fonseca NA, He Y, Kahles A, Lehmann KV, Liu F, Shiraishi Y, Soulette CM, Urban L, Greger L, Li S, Liu D, Perry MD, Xiang Q, Zhang F, Zhang J, Bailey P, Erkek S, Hoadley KA, Hou Y, Huska MR, Kilpinen H, Korbel JO, Marin MG, Markowski J, Nandi T, Pan-Hammarstr?m Q, Pedamallu CS, Siebert R, Stark SG, Su H, Tan P, Waszak SM, Yung C, Zhu S, Awadalla P, Creighton CJ, Meyerson M, Ouellette BFF, Wu K, Yang H, PCAWG Transcriptome Working Group, Brazma A, Brooks AN, G?ke J, R?tsch G, Schwarz RF, Stegle O, Zhang Z, PCAWG ConsortiumNatureGenomic basis for RNA alterations in cancer. Nature. 2020 02; 578(7793):129-136.Nature2020-02-05T00:00:002020Genomic basis for RNA alterations in cancer.Authorship 977836932047324Yuan Y, Ju YS, Kim Y, Li J, Wang Y, Yoon CJ, Yang Y, Martincorena I, Creighton CJ, Weinstein JN, Xu Y, Han L, Kim HL, Nakagawa H, Park K, Campbell PJ, Liang H, PCAWG ConsortiumNature geneticsPublisher Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat Genet. 2023 May; 55(5):893.Nat Genet2023-05-01T00:00:002023Publisher Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers.true1ProfessorProfessorAuthorship 979336332184864Demirel G, Guzel E, Creighton CJ, Ozturk YE, Kucuk C, Asliyuksek H, Yurdun TIranian journal of pharmaceutical research : IJPRMDMA Abuse in Relation to MicroRNA Variation in Human Brain Ventral Tegmental Area and Nucleus Accumbens. Iran J Pharm Res. 2019; 18(4):1989-1999.Iran J Pharm Res2019-01-01T00:00:002019MDMA Abuse in Relation to MicroRNA Variation in Human Brain Ventral Tegmental Area and Nucleus Accumbens.Authorship 1152008Authorship 988192932341528Yuan Y, Ju YS, Kim Y, Li J, Wang Y, Yoon CJ, Yang Y, Martincorena I, Creighton CJ, Weinstein JN, Xu Y, Han L, Kim HL, Nakagawa H, Park K, Campbell PJ, Liang H, PCAWG ConsortiumNature geneticsAuthor Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat Genet. 2023 May; 55(5):892.Nat Genet2023-05-01T00:00:002023Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers.Authorship 116076932359397Msaouel P, Malouf GG, Su X, Yao H, Tripathi DN, Soeung M, Gao J, Rao P, Coarfa C, Creighton CJ, Bertocchio JP, Kunnimalaiyaan S, Multani AS, Blando J, He R, Shapiro DD, Perelli L, Srinivasan S, Carbone F, Pili? PG, Karki M, Seervai RNH, Vokshi BH, Lopez-Terrada D, Cheng EH, Tang X, Lu W, Wistuba II, Thompson TC, Davidson I, Giuliani V, Schlacher K, Carugo A, Heffernan TP, Sharma P, Karam JA, Wood CG, Walker CL, Genovese G, Tannir NMCancer cellComprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. Cancer Cell. 2020 05 11; 37(5):720-734.e13.Cancer Cell2020-04-30T00:00:002020Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma.Authorship 9889629Authorship 9909921032497036Kim O, Park EY, Klinkebiel DL, Pack SD, Shin YH, Abdullaev Z, Emerson RE, Coffey DM, Kwon SY, Creighton CJ, Kwon S, Chang EC, Chiang T, Yatsenko AN, Chien J, Cheon DJ, Yang-Hartwich Y, Nakshatri H, Nephew KP, Behringer RR, Fern?ndez FM, Cho CH, Vanderhyden B, Drapkin R, Bast RC, Miller KD, Karpf AR, Kim JPLoS geneticsIn vivo?modeling of metastatic human high-grade serous ovarian cancer in mice. PLoS Genet. 2020 06; 16(6):e1008808.PLoS Genet2020-06-04T00:00:002020In vivo?modeling of metastatic human high-grade serous ovarian cancer in mice.Authorship 9936428Authorship 9938501332627901Kwon OJ, Choi JM, Zhang L, Jia D, Li Z, Zhang Y, Jung SY, Creighton CJ, Xin LStem cells (Dayton, Ohio)The Sca-1+ and Sca-1- mouse prostatic luminal cell lineages are independently sustained. Stem Cells. 2020 11; 38(11):1479-1491.Stem Cells2020-08-08T00:00:002020The Sca-1+ and Sca-1- mouse prostatic luminal cell lineages are independently sustained.32641413Midorikawa Y, Yamamoto S, Tatsuno K, Renard-Guillet C, Tsuji S, Hayashi A, Ueda H, Fukuda S, Fujita T, Katoh H, Ishikawa S, Covington KR, Creighton CJ, Sugitani M, Wheeler DA, Shibata T, Nagae G, Takayama T, Aburatani HCancer researchAccumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression. Cancer Res. 2020 09 15; 80(18):3810-3819.Cancer Res2020-07-08T00:00:002020Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression.Authorship 9961106Authorship 9962371432753652Bajaj R, Kundu ST, Grzeskowiak CL, Fradette JJ, Scott KL, Creighton CJ, Gibbons DLOncogeneIMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion. Oncogene. 2020 09; 39(37):5979-5994.Oncogene2020-08-04T00:00:002020IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion.32763065Behrens C, Rocha P, Parra ER, Feng L, Rodriguez-Canales J, Solis LM, Mino B, Zhang J, Gibbons DL, Sepesi B, Rice D, Heymach JV, Moran C, Creighton CJ, Lee JJ, Kadara H, Wistuba IIClinical lung cancerFemale Gender Predicts Augmented Immune Infiltration in Lung Adenocarcinoma. Clin Lung Cancer. 2021 05; 22(3):e415-e424.Clin Lung Cancer2020-06-14T00:00:002020Female Gender Predicts Augmented Immune Infiltration in Lung Adenocarcinoma.Authorship 1173491Authorship 9980075Authorship 998146932843721Wang X, Wendel JRH, Emerson RE, Broaddus RR, Creighton CJ, Rusch DB, Buechlein A, DeMayo FJ, Lydon JP, Hawkins SMOncogenePten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma. Oncogene. 2020 10; 39(40):6286-6299.Oncogene2020-08-25T00:00:002020Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma.32855410Vykoukal J, Fahrmann JF, Gregg JR, Tang Z, Basourakos S, Irajizad E, Park S, Yang G, Creighton CJ, Fleury A, Mayo J, Paulucci-Holthauzen A, Dennison JB, Murage E, Peterson CB, Davis JW, Kim J, Hanash S, Thompson TCNature communicationsCaveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer. Nat Commun. 2020 08 27; 11(1):4279.Nat Commun2020-08-27T00:00:002020Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer.Authorship 9996201132931483Tan X, Shi L, Banerjee P, Liu X, Guo HF, Yu J, Bota-Rabassedas N, Rodriguez BL, Gibbons DL, Russell WK, Creighton CJ, Kurie JMThe Journal of clinical investigationA protumorigenic secretory pathway activated by p53 deficiency in lung adenocarcinoma. J Clin Invest. 2021 01 04; 131(1).J Clin Invest2021-01-04T00:00:002021A protumorigenic secretory pathway activated by p53 deficiency in lung adenocarcinoma.Authorship 10014327Authorship 10021998Authorship 1002205533022812Ding Y, Lee M, Gao Y, Bu P, Coarfa C, Miles B, Sreekumar A, Creighton CJ, Ayala GThe ProstateNeuropeptide Y nerve paracrine regulation of prostate cancer oncogenesis and therapy resistance. Prostate. 2021 01; 81(1):58-71.Prostate2020-10-06T00:00:002020Neuropeptide Y nerve paracrine regulation of prostate cancer oncogenesis and therapy resistance.33023986Wetendorf M, Li R, Wu SP, Liu J, Creighton CJ, Wang T, Janardhan KS, Willson CJ, Lanz RB, Murphy BD, Lydon JP, DeMayo FJScience signalingConstitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms. Sci Signal. 2020 10 06; 13(652).Sci Signal2020-10-06T00:00:002020Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms.true1ProfessorProfessor2ProfessorProfessorAuthorship 10039043Authorship 1003906331289359Kim SJ, Garcia-Recio S, Creighton CJ, Perou CM, Rosen JMOncogeneAlterations in Wnt- and/or STAT3 signaling pathways and the immune microenvironment during metastatic progression. Oncogene. 2019 08; 38(31):5942-5958.Oncogene2019-07-09T00:00:002019Alterations in Wnt- and/or STAT3 signaling pathways and the immune microenvironment during metastatic progression.31558798Kim SJ, Garcia-Recio S, Creighton CJ, Perou CM, Rosen JMOncogeneCorrection: Alterations in Wnt- and/or STAT3 signaling pathways and the immune microenvironment during metastatic progression. Oncogene. 2020 Jan; 39(4):950.Oncogene2020-01-01T00:00:002020Correction: Alterations in Wnt- and/or STAT3 signaling pathways and the immune microenvironment during metastatic progression.Authorship 1131414Authorship 1007041333330620Tripathi SC, Deshmukh V, Creighton CJ, Patil AFrontiers in molecular biosciencesRenal Carcinoma Is Associated With Increased Risk of Coronavirus Infections. Front Mol Biosci. 2020; 7:579422.Front Mol Biosci2020-11-20T00:00:002020Renal Carcinoma Is Associated With Increased Risk of Coronavirus Infections.Authorship 10078331033367832Carlson JC, Cantu Gutierrez M, Lozzi B, Huang-Hobbs E, Turner WD, Tepe B, Zhang Y, Herman AM, Rao G, Creighton CJ, Wythe JD, Deneen BNeuro-oncologyIdentification of diverse tumor endothelial cell populations in malignant glioma. Neuro Oncol. 2021 06 01; 23(6):932-944.Neuro Oncol2021-06-01T00:00:002021Identification of diverse tumor endothelial cell populations in malignant glioma.Authorship 10099151Authorship 100996712Authorship 1010086733494957Creighton CJTrends in genetics : TIGPortals for Exploring Noncoding Variants in Pediatric Cancer. Trends Genet. 2021 04; 37(4):297-298.Trends Genet2021-01-22T00:00:002021Portals for Exploring Noncoding Variants in Pediatric Cancer.33500360Addison JB, Voronkova MA, Fugett JH, Lin CC, Linville NC, Trinh B, Livengood RH, Smolkin MB, Schaller MD, Ruppert JM, Pugacheva EN, Creighton CJ, Ivanov AVMolecular cancer research : MCRFunctional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer Metastasis. Mol Cancer Res. 2021 05; 19(5):784-798.Mol Cancer Res2021-01-26T00:00:002021Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer Metastasis.33510359Chen F, Zhang Y, Sucgang R, Ramani S, Corry D, Kheradmand F, Creighton CJScientific reportsMeta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors. Sci Rep. 2021 01 28; 11(1):2459.Sci Rep2021-01-28T00:00:002021Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors.Authorship 10108993Authorship 1011127533568653Zhang Y, Chen F, Donehower LA, Scheurer ME, Creighton CJNature communicationsA pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement. Nat Commun. 2021 02 10; 12(1):937.Nat Commun2021-02-10T00:00:002021A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement.33554123Chen F, Zhang Y, Creighton CJNAR cancerSystematic identification of non-coding somatic single nucleotide variants associated with altered transcription and DNA methylation in adult and pediatric cancers. NAR Cancer. 2021 Mar; 3(1):zcab001.NAR Cancer2021-02-01T00:00:002021Systematic identification of non-coding somatic single nucleotide variants associated with altered transcription and DNA methylation in adult and pediatric cancers.Authorship 10115478Authorship 101226911Authorship 1012760533586682Shen T, Wang W, Zhou W, Coleman I, Cai Q, Dong B, Ittmann MM, Creighton CJ, Bian Y, Meng Y, Rowley DR, Nelson PS, Moore DD, Yang FThe Journal of clinical investigationMAPK4 promotes prostate cancer by concerted activation of androgen receptor and AKT. J Clin Invest. 2021 02 15; 131(4).J Clin Invest2021-02-15T00:00:002021MAPK4 promotes prostate cancer by concerted activation of androgen receptor and AKT.33627787Monsivais D, Vasquez YM, Chen F, Zhang Y, Chandrashekar DS, Faver JC, Masand RP, Scheurer ME, Varambally S, Matzuk MM, Creighton CJOncogeneMass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers. Oncogene. 2021 03; 40(11):2081-2095.Oncogene2021-02-24T00:00:002021Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers.33664454Lee HC, Ou CH, Huang YC, Hou PC, Creighton CJ, Lin YS, Hu CY, Lin SCOncogeneYAP1 overexpression contributes to the development of enzalutamide resistance by induction of cancer stemness and lipid metabolism in prostate cancer. Oncogene. 2021 04; 40(13):2407-2421.Oncogene2021-03-04T00:00:002021YAP1 overexpression contributes to the development of enzalutamide resistance by induction of cancer stemness and lipid metabolism in prostate cancer.true1Assistant ProfessorAssistant ProfessorAuthorship 1014262333743584Zhang Y, Chen F, Creighton CJBMC bioinformaticsSVExpress: identifying gene features altered recurrently in expression with nearby structural variant breakpoints. BMC Bioinformatics. 2021 Mar 21; 22(1):135.BMC Bioinformatics2021-03-21T00:00:002021SVExpress: identifying gene features altered recurrently in expression with nearby structural variant breakpoints.Authorship 101665119Authorship 10167622133882319Bota-Rabassedas N, Banerjee P, Niu Y, Cao W, Luo J, Xi Y, Tan X, Sheng K, Ahn YH, Lee S, Parra ER, Rodriguez-Canales J, Albritton J, Weiger M, Liu X, Guo HF, Yu J, Rodriguez BL, Firestone JJA, Mino B, Creighton CJ, Solis LM, Villalobos P, Raso MG, Sazer DW, Gibbons DL, Russell WK, Longmore GD, Wistuba II, Wang J, Chapman HA, Miller JS, Zong C, Kurie JMCell reportsContextual cues from cancer cells govern cancer-associated fibroblast heterogeneity. Cell Rep. 2021 04 20; 35(3):109009.Cell Rep2021-04-20T00:00:002021Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity.33875777Guo HF, Bota-Rabassedas N, Terajima M, Leticia Rodriguez B, Gibbons DL, Chen Y, Banerjee P, Tsai CL, Tan X, Liu X, Yu J, Tokmina-Roszyk M, Stawikowska R, Fields GB, Miller MD, Wang X, Lee J, Dalby KN, Creighton CJ, Phillips GN, Tainer JA, Yamauchi M, Kurie JMCommunications biologyA collagen glucosyltransferase drives lung adenocarcinoma progression in mice. Commun Biol. 2021 04 19; 4(1):482.Commun Biol2021-04-19T00:00:002021A collagen glucosyltransferase drives lung adenocarcinoma progression in mice.Authorship 1017315633921461Sardar D, Lozzi B, Woo J, Huang TW, Cvetkovic C, Creighton CJ, Krencik R, Deneen BInternational journal of molecular sciencesMapping Astrocyte Transcriptional Signatures in Response to Neuroactive Compounds. Int J Mol Sci. 2021 Apr 12; 22(8).Int J Mol Sci2021-04-12T00:00:002021Mapping Astrocyte Transcriptional Signatures in Response to Neuroactive Compounds.Authorship 1018957534012099Lee HC, Ou CH, Huang YC, Hou PC, Creighton CJ, Lin YS, Hu CY, Lin SCOncogeneCorrection: YAP1 overexpression contributes to the development of enzalutamide resistance by induction of cancer stemness and lipid metabolism in prostate cancer. Oncogene. 2021 Jun; 40(23):4060.Oncogene2021-06-01T00:00:002021Correction: YAP1 overexpression contributes to the development of enzalutamide resistance by induction of cancer stemness and lipid metabolism in prostate cancer.Authorship 102063810Authorship 10206491134099494Yue F, Jiang W, Ku AT, Young AIJ, Zhang W, Souto EP, Gao Y, Yu Z, Wang Y, Creighton CJ, Nagi C, Wang T, Hilsenbeck SG, Feng XH, Huang S, Coarfa C, Zhang XH, Liu Q, Lin X, Li YCancer researchA Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis. Cancer Res. 2021 09 01; 81(17):4441-4454.Cancer Res2021-06-07T00:00:002021A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis.34099644Monsivais D, Nagashima T, Prunskaite-Hyyryl?inen R, Nozawa K, Shimada K, Tang S, Hamor C, Agno JE, Chen F, Masand RP, Young SL, Creighton CJ, DeMayo FJ, Ikawa M, Lee SJ, Matzuk MMNature communicationsEndometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis. Nat Commun. 2021 06 07; 12(1):3386.Nat Commun2021-06-07T00:00:002021Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis.true1Associate ProfessorAssociate ProfessorAuthorship 10214101134144984Tan X, Banerjee P, Shi L, Xiao GY, Rodriguez BL, Grzeskowiak CL, Liu X, Yu J, Gibbons DL, Russell WK, Creighton CJ, Kurie JMScience advancesp53 loss activates prometastatic secretory vesicle biogenesis in the Golgi. Sci Adv. 2021 06; 7(25).Sci Adv2021-06-18T00:00:002021p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi.Authorship 10237221034155143Shi L, Tan X, Liu X, Yu J, Bota-Rabassedas N, Niu Y, Luo J, Xi Y, Zong C, Creighton CJ, Glenn JS, Wang J, Kurie JMProceedings of the National Academy of Sciences of the United States of AmericaAddiction to Golgi-resident PI4P synthesis in chromosome 1q21.3-amplified lung adenocarcinoma cells. Proc Natl Acad Sci U S A. 2021 06 22; 118(25).Proc Natl Acad Sci U S A2021-06-22T00:00:002021Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3-amplified lung adenocarcinoma cells.24122835Fan Y, Ge N, Wang X, Sun W, Mao R, Bu W, Creighton CJ, Zheng P, Vasudevan S, An L, Yang J, Zhao YJ, Zhang H, Li XN, Rao PH, Leung E, Lu YJ, Gray JW, Schiff R, Hilsenbeck SG, Osborne CK, Yang J, Zhang HThe Journal of pathologyAmplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells. J Pathol. 2014 Jan; 232(1):75-86.J Pathol2014-01-01T00:00:002014Amplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells.Authorship 1225472Authorship 1163021Authorship 10326041434706306Wang Z, Hulsurkar M, Zhuo L, Xu J, Yang H, Naderinezhad S, Wang L, Zhang G, Ai N, Li L, Chang JT, Zhang S, Fazli L, Creighton CJ, Bai F, Ittmann MM, Gleave ME, Li WNeoplasia (New York, N.Y.)CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation. Neoplasia. 2021 11; 23(11):1147-1165.Neoplasia2021-10-24T00:00:002021CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation.Authorship 103365414Authorship 10340137Authorship 10342841134767444Cai Q, Zhou W, Wang W, Dong B, Han D, Shen T, Creighton CJ, Moore DD, Yang FScience advancesMAPK6-AKT signaling promotes tumor growth and resistance to mTOR kinase blockade. Sci Adv. 2021 Nov 12; 7(46):eabi6439.Sci Adv2021-11-12T00:00:002021MAPK6-AKT signaling promotes tumor growth and resistance to mTOR kinase blockade.34788622Zhang Y, Chen F, Pleasance E, Williamson L, Grisdale CJ, Titmuss E, Laskin J, Jones SJM, Cortes-Ciriano I, Marra MA, Creighton CJCell reportsRearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy. Cell Rep. 2021 11 16; 37(7):110023.Cell Rep2021-11-16T00:00:002021Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy.34732702Banerjee P, Xiao GY, Tan X, Zheng VJ, Shi L, Rabassedas MNB, Guo HF, Liu X, Yu J, Diao L, Wang J, Russell WK, Roszik J, Creighton CJ, Kurie JMNature communicationsThe EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells. Nat Commun. 2021 11 03; 12(1):6354.Nat Commun2021-11-03T00:00:002021The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells.Authorship 1174675Authorship 10349415Authorship 1035047734864569Chen F, Chandrashekar DS, Scheurer ME, Varambally S, Creighton CJNeoplasia (New York, N.Y.)Global molecular alterations involving recurrence or progression of pediatric brain tumors. Neoplasia. 2022 01; 24(1):22-33.Neoplasia2021-12-03T00:00:002021Global molecular alterations involving recurrence or progression of pediatric brain tumors.34874914Tan X, Banerjee P, Liu X, Yu J, Lee S, Ahn YH, Creighton CJ, Kurie JMJCI insightTranscriptional control of a collagen deposition and adhesion process that promotes lung adenocarcinoma growth and metastasis. JCI Insight. 2022 01 11; 7(1).JCI Insight2022-01-11T00:00:002022Transcriptional control of a collagen deposition and adhesion process that promotes lung adenocarcinoma growth and metastasis.Authorship 10366141434987156Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang FF, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JTNature communicationsAuthor Correction: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun. 2022 Jan 05; 13(1):190.Nat Commun2022-01-05T00:00:002022Author Correction: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling.Authorship 103703715Authorship 10372281134999736Kwon OJ, Zhang B, Jia D, Zhang L, Wei X, Zhou Z, Liu D, Huynh KT, Zhang K, Zhang Y, Labhart P, Sboner A, Barbieri C, Haffner MC, Creighton CJ, Xin LOncogeneElevated expression of the colony-stimulating factor 1 (CSF1) induces prostatic intraepithelial neoplasia dependent of epithelial-Gp130. Oncogene. 2022 02; 41(9):1309-1323.Oncogene2022-01-08T00:00:002022Elevated expression of the colony-stimulating factor 1 (CSF1) induces prostatic intraepithelial neoplasia dependent of epithelial-Gp130.35017531Wang W, Han D, Cai Q, Shen T, Dong B, Lewis MT, Wang R, Meng Y, Zhou W, Yi P, Creighton CJ, Moore DD, Yang FNature communicationsMAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade. Nat Commun. 2022 01 11; 13(1):245.Nat Commun2022-01-11T00:00:002022MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade.Authorship 103965027Authorship 10401215Authorship 10405281135138907Li J, Lu H, Ng PK, Pantazi A, Ip CKM, Jeong KJ, Amador B, Tran R, Tsang YH, Yang L, Song X, Dogruluk T, Ren X, Hadjipanayis A, Bristow CA, Lee S, Kucherlapati M, Parfenov M, Tang J, Seth S, Mahadeshwar HS, Mojumdar K, Zeng D, Zhang J, Protopopov A, Seidman JG, Creighton CJ, Lu Y, Sahni N, Shaw KR, Meric-Bernstam F, Futreal A, Chin L, Scott KL, Kucherlapati R, Mills GB, Liang HScience advancesA functional genomic approach to actionable gene fusions for precision oncology. Sci Adv. 2022 02 11; 8(6):eabm2382.Sci Adv2022-02-09T00:00:002022A functional genomic approach to actionable gene fusions for precision oncology.35078134Chandrashekar DS, Karthikeyan SK, Korla PK, Patel H, Shovon AR, Athar M, Netto GJ, Qin ZS, Kumar S, Manne U, Creighton CJ, Varambally SNeoplasia (New York, N.Y.)UALCAN: An update to the integrated cancer data analysis platform. Neoplasia. 2022 03; 25:18-27.Neoplasia2022-01-22T00:00:002022UALCAN: An update to the integrated cancer data analysis platform.35045964Bill KLJ, Garnett J, Meaux I, Ma X, Creighton CJ, Bolshakov S, Barriere C, Debussche L, Lazar AJ, Prudner BC, Casadei L, Braggio D, Lopez G, Zewdu A, Bid H, Dina L, Pollock REClinical cancer research : an official journal of the American Association for Cancer ResearchCorrection: SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma. Clin Cancer Res. 2022 Jan 15; 28(2):431.Clin Cancer Res2022-01-15T00:00:002022Correction: SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma.Authorship 1186531Authorship 1365522Authorship 1368782Authorship 1373543Authorship 1378131Authorship 1379347Authorship 137969523934967Mishra DK, Creighton CJ, Zhang Y, Gibbons DL, Kurie JM, Kim MPInternational journal of cancerGene expression profile of A549 cells from tissue of 4D model predicts poor prognosis in lung cancer patients. Int J Cancer. 2014 Feb 15; 134(4):789-98.Int J Cancer2013-09-03T00:00:002013Gene expression profile of A549 cells from tissue of 4D model predicts poor prognosis in lung cancer patients.23981300Peng S, Creighton CJ, Zhang Y, Sen B, Mazumdar T, Myers JN, Lai SY, Woolfson A, Lorenzi MV, Bell D, Williams MD, Johnson FMJournal of translational medicineTumor grafts derived from patients with head and neck squamous carcinoma authentically maintain the molecular and histologic characteristics of human cancers. J Transl Med. 2013 Aug 27; 11:198.J Transl Med2013-08-27T00:00:002013Tumor grafts derived from patients with head and neck squamous carcinoma authentically maintain the molecular and histologic characteristics of human cancers.24176914Li X, Large MJ, Creighton CJ, Lanz RB, Jeong JW, Young SL, Lessey BA, Palomino WA, Tsai SY, Demayo FJMolecular endocrinology (Baltimore, Md.)COUP-TFII regulates human endometrial stromal genes involved in inflammation. Mol Endocrinol. 2013 Dec; 27(12):2041-54.Mol Endocrinol2013-10-31T00:00:002013COUP-TFII regulates human endometrial stromal genes involved in inflammation.24204309Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BWPLoS geneticsAcceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization. PLoS Genet. 2013 Oct; 9(10):e1003900.PLoS Genet2013-10-24T00:00:002013Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization.24244176Clementi C, Tripurani SK, Large MJ, Edson MA, Creighton CJ, Hawkins SM, Kovanci E, Kaartinen V, Lydon JP, Pangas SA, DeMayo FJ, Matzuk MMPLoS geneticsActivin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. PLoS Genet. 2013 Nov; 9(11):e1003863.PLoS Genet2013-11-14T00:00:002013Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans.24386073Creighton CJPloS oneWidespread molecular patterns associated with drug sensitivity in breast cancer cell lines, with implications for human tumors. PLoS One. 2013; 8(12):e71158.PLoS One2013-12-27T00:00:002013Widespread molecular patterns associated with drug sensitivity in breast cancer cell lines, with implications for human tumors.Authorship 1045916535562349Zhang Y, Chen F, Chandrashekar DS, Varambally S, Creighton CJNature communicationsProteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways. Nat Commun. 2022 05 13; 13(1):2669.Nat Commun2022-05-13T00:00:002022Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways.Authorship 10470981735654454Kundu ST, Rodriguez BL, Gibson LA, Warner AN, Perez MG, Bajaj R, Fradette JJ, Class CA, Solis LM, Rojas Alvarez FR, Wistuba II, Diao L, Chen F, Sachdeva M, Wang J, Kirsch DG, Creighton CJ, Gibbons DLGenes & developmentThe microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell response. Genes Dev. 2022 05 01; 36(9-10):582-600.Genes Dev2022-05-01T00:00:002022The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell response.Authorship 12127011Authorship 166777Authorship 105701316Authorship 105808316Authorship 106126311Authorship 10564938Authorship 10580335Authorship 10547756Authorship 105824140Authorship 105452217Authorship 10571991Authorship 1058028136693152Creighton CJCancer journal (Sudbury, Mass.)Gene Expression Profiles in Cancers and Their Therapeutic Implications. Cancer J. 2023 Jan-Feb 01; 29(1):9-14.Cancer J2023-01-01T00:00:002023Gene Expression Profiles in Cancers and Their Therapeutic Implications.36697831PCAWG Transcriptome Core Group, Calabrese C, Davidson NR, Demircioglu D, Fonseca NA, He Y, Kahles A, Lehmann KV, Liu F, Shiraishi Y, Soulette CM, Urban L, Greger L, Li S, Liu D, Perry MD, Xiang Q, Zhang F, Zhang J, Bailey P, Erkek S, Hoadley KA, Hou Y, Huska MR, Kilpinen H, Korbel JO, Marin MG, Markowski J, Nandi T, Pan-Hammarstr?m Q, Pedamallu CS, Siebert R, Stark SG, Su H, Tan P, Waszak SM, Yung C, Zhu S, Awadalla P, Creighton CJ, Meyerson M, Ouellette BFF, Wu K, Yang H, PCAWG Transcriptome Working Group, Brazma A, Brooks AN, G?ke J, R?tsch G, Schwarz RF, Stegle O, Zhang Z, PCAWG ConsortiumNatureAuthor Correction: Genomic basis for RNA alterations in cancer. Nature. 2023 Feb; 614(7948):E37.Nature2023-02-01T00:00:002023Author Correction: Genomic basis for RNA alterations in cancer.36261627Lin M, Ku AT, Dong J, Yue F, Jiang W, Ibrahim AA, Peng F, Creighton CJ, Nagi C, Gutierrez C, Rosen JM, Zhang XH, Hilsenbeck SG, Chen X, Du YN, Huang S, Shi A, Fan Z, Li YOncogeneSTAT5 confers lactogenic properties in breast tumorigenesis and restricts metastatic potential. Oncogene. 2022 11; 41(48):5214-5222.Oncogene2022-10-19T00:00:002022STAT5 confers lactogenic properties in breast tumorigenesis and restricts metastatic potential.36001375Si H, Zhao N, Pedroza A, Zaske AM, Rosen JM, Creighton CJ, Roarty KMolecular biology of the cellNoncanonical Wnt/Ror2 signaling regulates cell-matrix adhesion to prompt directional tumor cell invasion in breast cancer. Mol Biol Cell. 2022 09 15; 33(11):ar103.Mol Biol Cell2022-08-24T00:00:002022Noncanonical Wnt/Ror2 signaling regulates cell-matrix adhesion to prompt directional tumor cell invasion in breast cancer.36369237Jia D, Zhou Z, Kwon OJ, Zhang L, Wei X, Zhang Y, Yi M, Roudier MP, Regier MC, Dumpit R, Nelson PS, Headley M, True L, Lin DW, Morrissey C, Creighton CJ, Xin LNature communicationsStromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity. Nat Commun. 2022 11 11; 13(1):6828.Nat Commun2022-11-11T00:00:002022Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity.36481652Zhang Y, Chen F, Fonseca NA, He Y, Fujita M, Nakagawa H, Zhang Z, Brazma A, PCAWG Transcriptome Working Group, PCAWG Structural Variation Working Group, Creighton CJ, PCAWG ConsortiumNature communicationsAuthor Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. Nat Commun. 2022 Dec 08; 13(1):7572.Nat Commun2022-12-08T00:00:002022Author Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.36585450Garcia-Recio S, Hinoue T, Wheeler GL, Kelly BJ, Garrido-Castro AC, Pascual T, De Cubas AA, Xia Y, Felsheim BM, McClure MB, Rajkovic A, Karaesmen E, Smith MA, Fan C, Ericsson PIG, Sanders ME, Creighton CJ, Bowen J, Leraas K, Burns RT, Coppens S, Wheless A, Rezk S, Garrett AL, Parker JS, Foy KK, Shen H, Park BH, Krop I, Anders C, Gastier-Foster J, Rimawi MF, Nanda R, Lin NU, Isaacs C, Marcom PK, Storniolo AM, Couch FJ, Chandran U, Davis M, Silverstein J, Ropelewski A, Liu MC, Hilsenbeck SG, Norton L, Richardson AL, Symmans WF, Wolff AC, Davidson NE, Carey LA, Lee AV, Balko JM, Hoadley KA, Laird PW, Mardis ER, King TA, AURORA US Network, Perou CMNature cancerMultiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis. Nat Cancer. 2023 01; 4(1):128-147.Nat Cancer2022-12-30T00:00:002022Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis.36495097Creighton CJMass spectrometry reviewsClinical proteomics towards multiomics in cancer. Mass Spectrom Rev. 2022 Dec 10; e21827.Mass Spectrom Rev2022-12-10T00:00:002022Clinical proteomics towards multiomics in cancer.35948570Zhang Y, Chen F, Chandrashekar DS, Varambally S, Creighton CJNature communicationsAuthor Correction: Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways. Nat Commun. 2022 Aug 10; 13(1):4688.Nat Commun2022-08-10T00:00:002022Author Correction: Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways.36070687Wei X, Zhang L, Zhang Y, Cooper C, Brewer C, Tsai CF, Wang YT, Glaz M, Wessells HB, Que J, Titus MA, Cirulli V, Glaser A, Liu T, Reder NP, Creighton CJ, Xin LCell reportsAblating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis. Cell Rep. 2022 09 06; 40(10):111313.Cell Rep2022-09-06T00:00:002022Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis.Authorship 1750510Authorship 1063317336731467Zhang Y, Chen F, Creighton CJCell reports. MedicinePan-cancer molecular subtypes of metastasis reveal distinct and evolving transcriptional programs. Cell Rep Med. 2023 02 21; 4(2):100932.Cell Rep Med2023-02-01T00:00:002023Pan-cancer molecular subtypes of metastasis reveal distinct and evolving transcriptional programs.Authorship 1063469936757799Tan X, Xiao GY, Wang S, Shi L, Zhao Y, Liu X, Yu J, Russell WK, Creighton CJ, Kurie JMThe Journal of clinical investigationEMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer. J Clin Invest. 2023 04 03; 133(7).J Clin Invest2023-04-03T00:00:002023EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer.Authorship 10656991236906706Kriseman ML, Tang S, Liao Z, Jiang P, Parks SE, Cope DI, Yuan F, Chen F, Masand RP, Castro PD, Ittmann MM, Creighton CJ, Tan Z, Monsivais DCommunications biologySMAD2/3 signaling in the uterine epithelium controls endometrial cell homeostasis and regeneration. Commun Biol. 2023 03 11; 6(1):261.Commun Biol2023-03-11T00:00:002023SMAD2/3 signaling in the uterine epithelium controls endometrial cell homeostasis and regeneration.Authorship 106620713Authorship 1066204936944732Yuan Y, Ju YS, Kim Y, Li J, Wang Y, Yoon CJ, Yang Y, Martincorena I, Creighton CJ, Weinstein JN, Xu Y, Han L, Kim HL, Nakagawa H, Park K, Campbell PJ, Liang H, PCAWG ConsortiumNature geneticsAuthor Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat Genet. 2023 Jun; 55(6):1078.Nat Genet2023-06-01T00:00:002023Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers.36945465Reddy P, Zhao D, Ravikumar V, Lauder E, Li L, Sun Y, Oravecz-Wilson K, Brooks M, Keller E, Chen F, Maneix L, Santibanez A, Creighton C, Rao AResearch squareInflammatory memory restrains intestinal stem cell regeneration. Res Sq. 2023 Mar 07.Res Sq2023-03-07T00:00:002023Inflammatory memory restrains intestinal stem cell regeneration.Authorship 1217148Authorship 127077Authorship 107091410Authorship 10697332Authorship 1070907537143122Yang L, Chen X, Lee C, Shi J, Lawrence EB, Zhang L, Li Y, Gao N, Jung SY, Creighton CJ, Li JJ, Cui Y, Arimura S, Lei Y, Li W, Shen LJournal of experimental & clinical cancer research : CRFunctional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer. J Exp Clin Cancer Res. 2023 May 04; 42(1):113.J Exp Clin Cancer Res2023-05-04T00:00:002023Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer.37141409Monsivais D, Parks SE, Chandrashekar DS, Varambally S, Creighton CJOncotargetUsing cancer proteomics data to identify gene candidates for therapeutic targeting. Oncotarget. 2023 05 04; 14:399-412.Oncotarget2023-05-04T00:00:002023Using cancer proteomics data to identify gene candidates for therapeutic targeting.37172086Bu W, Creighton CJ, Heavener KS, Gutierrez C, Dou Y, Ku AT, Zhang Y, Jiang W, Urrutia J, Jiang W, Yue F, Jia L, Ibrahim AA, Zhang B, Huang S, Li YScience advancesEfficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice. Sci Adv. 2023 05 12; 9(19):eade0059.Sci Adv2023-05-12T00:00:002023Efficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice.Authorship 10734992Authorship 107453710Authorship 1072960137333115Avadhanula V, Creighton C, Ferlic-Stark L, Sucgang R, Zhang Y, Nagaraj D, Nicholson E, Rajan A, Menon V, Doddapaneni H, Muzny D, Metcalf G, Cregeen SJ, Hoffman K, Gibbs R, Petrosino J, Piedra PResearch squareLongitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load. Res Sq. 2023 Jun 05.Res Sq2023-06-05T00:00:002023Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load.37279148Creighton CJ, Zhang F, Zhang Y, Castro P, Hu R, Islam M, Ghosh S, Ittmann M, Kwabi-Addo BEpigeneticsComparative and integrative analysis of transcriptomic and epigenomic-wide DNA methylation changes in African American prostate cancer. Epigenetics. 2023 12; 18(1):2180585.Epigenetics2023-12-01T00:00:002023Comparative and integrative analysis of transcriptomic and epigenomic-wide DNA methylation changes in African American prostate cancer.37292999Avadhanula V, Creighton CJ, Ferlic-Stark L, Sucgang R, Zhang Y, Nagaraj D, Nicholson EG, Rajan A, Menon VK, Doddapaneni H, Muzny DM, Metcalf G, Cregeen SJJ, Hoffman KL, Gibbs RA, Petrosino J, Piedra PAbioRxiv : the preprint server for biologyLongitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load. bioRxiv. 2023 May 25.bioRxiv2023-05-25T00:00:002023Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load.37400528Zhou Z, Jia D, Kwon O, Li S, Sun H, Roudier MP, Lin DW, True L, Morrissey C, Creighton CJ, Lee JK, Xin LOncogeneAndrogen-regulated stromal complement component 7 (C7) suppresses prostate cancer growth. Oncogene. 2023 08; 42(32):2428-2438.Oncogene2023-07-03T00:00:002023Androgen-regulated stromal complement component 7 (C7) suppresses prostate cancer growth.Authorship 10783805Authorship 10782636Authorship 10786151037621654Collins KE, Wang X, Klymenko Y, Davis NB, Martinez MC, Zhang C, So K, Buechlein A, Rusch DB, Creighton CJ, Hawkins SMFrontiers in endocrinologyTranscriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis. Front Endocrinol (Lausanne). 2023; 14:1162786.Front Endocrinol (Lausanne)2023-08-09T00:00:002023Transcriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis.37683055Capik O, Gundogdu B, Tatar A, Sahin A, Chen F, Creighton CJ, Karatas OFJournal of cellular biochemistryOncogenic miR-1825 promotes head and neck carcinogenesis via targeting FREM1. J Cell Biochem. 2023 Oct; 124(10):1628-1645.J Cell Biochem2023-09-08T00:00:002023Oncogenic miR-1825 promotes head and neck carcinogenesis via targeting FREM1.37704602Chen F, Zhang Y, Chandrashekar DS, Varambally S, Creighton CJNature communicationsGlobal impact of somatic structural variation on the cancer proteome. Nat Commun. 2023 09 13; 14(1):5637.Nat Commun2023-09-13T00:00:002023Global impact of somatic structural variation on the cancer proteome.Authorship 10813932Authorship 152015Authorship 230205Authorship 1087005838227801Dunn TN, Cope DI, Tang S, Sirupangi T, Parks SE, Liao Z, Yuan F, Creighton CJ, Masand RP, Alpuing Radilla L, Guan X, Detti L, Monsivais D, Matzuk MMEndocrinologyInhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis. Endocrinology. 2024 Feb 20; 165(4).Endocrinology2024-02-20T00:00:002024Inhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis.Authorship 1087958638259096Yang L, Peery RC, Farmer LM, Gao X, Zhang Y, Creighton CJ, Zhang L, Shen LCancer research communicationsDietary Folate and Cofactors Accelerate Age-dependent p16 Epimutation to Promote Intestinal Tumorigenesis. Cancer Res Commun. 2024 01 19; 4(1):164-169.Cancer Res Commun2024-01-19T00:00:002024Dietary Folate and Cofactors Accelerate Age-dependent p16 Epimutation to Promote Intestinal Tumorigenesis.Authorship 10890841938355560Amara CS, Kami Reddy KR, Yuntao Y, Chan YS, Piyarathna DWB, Dobrolecki LE, Shih DJH, Shi Z, Xu J, Huang S, Ellis MJ, Apolo AB, Ballester LY, Gao J, Hansel DE, Lotan Y, Hodges HC, Lerner SP, Creighton CJ, Sreekumar A, Zheng WJ, Msaouel P, Kavuri SM, Putluri NNature communicationsThe IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer. Nat Commun. 2024 Feb 14; 15(1):1373.Nat Commun2024-02-14T00:00:002024The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer.Authorship 1090264438442712Chen F, Zhang Y, Sedlazeck FJ, Creighton CJCell reports. MedicineGermline structural variation globally impacts the cancer transcriptome including disease-relevant genes. Cell Rep Med. 2024 Mar 19; 5(3):101446.Cell Rep Med2024-03-04T00:00:002024Germline structural variation globally impacts the cancer transcriptome including disease-relevant genes.true1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 180824Authorship 183462Authorship 264072Authorship 236364Authorship 266466Authorship 222607Authorship 316001424374933Parikh N, Hilsenbeck S, Creighton CJ, Dayaram T, Shuck R, Shinbrot E, Xi L, Gibbs RA, Wheeler DA, Donehower LAThe Journal of pathologyEffects of TP53 mutational status on gene expression patterns across 10 human cancer types. J Pathol. 2014 Apr; 232(5):522-33.J Pathol2014-01-29T00:00:002014Effects of TP53 mutational status on gene expression patterns across 10 human cancer types.24008095Atkinson RL, Yang WT, Rosen DG, Landis MD, Wong H, Lewis MT, Creighton CJ, Sexton KR, Hilsenbeck SG, Sahin AA, Brewster AM, Woodward WA, Chang JCBreast cancer research : BCRCancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficiency. Breast Cancer Res. 2013; 15(5):R77.Breast Cancer Res2013-01-01T00:00:002013Cancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficiency.Authorship 36061Authorship 259284Authorship 378502Authorship 28104Authorship 3977022Authorship 401381Authorship 281312Authorship 1393957Authorship 1394463Authorship 1395737Authorship 30636124782509Xu Y, Zhang M, Ramos CA, Durett A, Liu E, Dakhova O, Liu H, Creighton CJ, Gee AP, Heslop HE, Rooney CM, Savoldo B, Dotti GBloodClosely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15. Blood. 2014 Jun 12; 123(24):3750-9.Blood2014-04-29T00:00:002014Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15.24476821Cancer Genome Atlas Research NetworkNatureComprehensive molecular characterization of urothelial bladder carcinoma. Nature. 2014 Mar 20; 507(7492):315-22.Nature2014-01-29T00:00:002014Comprehensive molecular characterization of urothelial bladder carcinoma.Authorship 1401108Authorship 14011115Authorship 14011214Authorship 1401131Authorship 1401141Authorship 1401151Authorship 1401161Authorship 1410663Authorship 1418775Authorship 1420295Authorship 1422388Authorship 1428807Authorship 1431164Authorship 143150424762440Yang Y, Ahn YH, Chen Y, Tan X, Guo L, Gibbons DL, Ungewiss C, Peng DH, Liu X, Lin SH, Thilaganathan N, Wistuba II, Rodriguez-Canales J, McLendon G, Creighton CJ, Kurie JMThe Journal of clinical investigationZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. J Clin Invest. 2014 Jun; 124(6):2696-708.J Clin Invest2014-04-24T00:00:002014ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.24681959Bharadwaj U, Eckols TK, Kolosov M, Kasembeli MM, Adam A, Torres D, Zhang X, Dobrolecki LE, Wei W, Lewis MT, Dave B, Chang JC, Landis MD, Creighton CJ, Mancini MA, Tweardy DJOncogeneDrug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene. 2015 Mar 12; 34(11):1341-53.Oncogene2014-03-31T00:00:002014Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer.23000897Cancer Genome Atlas NetworkNatureComprehensive molecular portraits of human breast tumours. Nature. 2012 Oct 04; 490(7418):61-70.Nature2012-09-23T00:00:002012Comprehensive molecular portraits of human breast tumours.22810696Cancer Genome Atlas NetworkNatureComprehensive molecular characterization of human colon and rectal cancer. Nature. 2012 Jul 18; 487(7407):330-7.Nature2012-07-18T00:00:002012Comprehensive molecular characterization of human colon and rectal cancer.21720365Cancer Genome Atlas Research NetworkNatureIntegrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29; 474(7353):609-15.Nature2011-06-29T00:00:002011Integrated genomic analyses of ovarian carcinoma.23435427Wardwell-Ozgo J, Dogruluk T, Gifford A, Zhang Y, Heffernan TP, van Doorn R, Creighton CJ, Chin L, Scott KLOncogeneHOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome. Oncogene. 2014 Feb 20; 33(8):1017-26.Oncogene2013-02-25T00:00:002013HOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome.24132643Zhang P, Garnett J, Creighton CJ, Al Sannaa GA, Igram DR, Lazar A, Liu X, Liu C, Pollock REThe Journal of pathologyEZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis. J Pathol. 2014 Feb; 232(3):308-18.J Pathol2014-02-01T00:00:002014EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis.24305876Carstens JL, Shahi P, Van Tsang S, Smith B, Creighton CJ, Zhang Y, Seamans A, Seethammagari M, Vedula I, Levitt JM, Ittmann MM, Rowley DR, Spencer DMCancer researchFGFR1-WNT-TGF-? signaling in prostate cancer mouse models recapitulates human reactive stroma. Cancer Res. 2014 Jan 15; 74(2):609-20.Cancer Res2013-12-04T00:00:002013FGFR1-WNT-TGF-? signaling in prostate cancer mouse models recapitulates human reactive stroma.24334762Geldres C, Savoldo B, Hoyos V, Caruana I, Zhang M, Yvon E, Del Vecchio M, Creighton CJ, Ittmann M, Ferrone S, Dotti GClinical cancer research : an official journal of the American Association for Cancer ResearchT lymphocytes redirected against the chondroitin sulfate proteoglycan-4 control the growth of multiple solid tumors both in vitro and in vivo. Clin Cancer Res. 2014 Feb 15; 20(4):962-71.Clin Cancer Res2013-12-13T00:00:002013T lymphocytes redirected against the chondroitin sulfate proteoglycan-4 control the growth of multiple solid tumors both in vitro and in vivo.24412363Kalsotra A, Singh RK, Gurha P, Ward AJ, Creighton CJ, Cooper TACell reportsThe Mef2 transcription network is disrupted in myotonic dystrophy heart tissue, dramatically altering miRNA and mRNA expression. Cell Rep. 2014 Jan 30; 6(2):336-45.Cell Rep2014-01-09T00:00:002014The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue, dramatically altering miRNA and mRNA expression.24571987Kommagani R, Szwarc MM, Kovanci E, Creighton CJ, O'Malley BW, Demayo FJ, Lydon JPBiology of reproductionA murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells. Biol Reprod. 2014 Apr; 90(4):75.Biol Reprod2014-04-10T00:00:002014A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells.24598160Villegas E, Kabotyanski EB, Shore AN, Creighton CJ, Westbrook TF, Rosen JMDevelopment (Cambridge, England)Plk2 regulates mitotic spindle orientation and mammary gland development. Development. 2014 Apr; 141(7):1562-71.Development2014-03-05T00:00:002014Plk2 regulates mitotic spindle orientation and mammary gland development.Authorship 3159218Authorship 342161Authorship 499008Authorship 376152Authorship 56372Authorship 404029Authorship 569824Authorship 571401Authorship 4035112Authorship 407371Authorship 1458475Authorship 14678512Authorship 1470534Authorship 1471586Authorship 147178723851498Zhang B, Chen H, Zhang L, Dakhova O, Zhang Y, Lewis MT, Creighton CJ, Ittmann MM, Xin LOncogeneA dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis. Oncogene. 2014 Jun 12; 33(24):3099-108.Oncogene2013-07-15T00:00:002013A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.24560667Liu S, Lai L, Zuo Q, Dai F, Wu L, Wang Y, Zhou Q, Liu J, Liu J, Li L, Lin Q, Creighton CJ, Costello MG, Huang S, Jia C, Liao L, Luo H, Fu J, Liu M, Yi Z, Xiao J, Li XJournal of molecular and cellular cardiologyPKA turnover by the REG?-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis. J Mol Cell Cardiol. 2014 Jul; 72:28-38.J Mol Cell Cardiol2014-02-20T00:00:002014PKA turnover by the REG?-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis.24874954Feng Q, Zhang Z, Shea MJ, Creighton CJ, Coarfa C, Hilsenbeck SG, Lanz R, He B, Wang L, Fu X, Nardone A, Song Y, Bradner J, Mitsiades N, Mitsiades CS, Osborne CK, Schiff R, O'Malley BWCell researchAn epigenomic approach to therapy for tamoxifen-resistant breast cancer. Cell Res. 2014 Jul; 24(7):809-19.Cell Res2014-05-30T00:00:002014An epigenomic approach to therapy for tamoxifen-resistant breast cancer.24945252Large MJ, Wetendorf M, Lanz RB, Hartig SM, Creighton CJ, Mancini MA, Kovanci E, Lee KF, Threadgill DW, Lydon JP, Jeong JW, DeMayo FJPLoS geneticsThe epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet. 2014 Jun; 10(6):e1004451.PLoS Genet2014-06-19T00:00:002014The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.24967583Karatas OF, Guzel E, Suer I, Ekici ID, Caskurlu T, Creighton CJ, Ittmann M, Ozen MPloS onemiR-1 and miR-133b are differentially expressed in patients with recurrent prostate cancer. PLoS One. 2014; 9(6):e98675.PLoS One2014-06-26T00:00:002014miR-1 and miR-133b are differentially expressed in patients with recurrent prostate cancer.Authorship 593503Authorship 612772Authorship 617421Authorship 629001Authorship 668748Authorship 1482928Authorship 148471525016594Putluri N, Maity S, Kommagani R, Kommangani R, Creighton CJ, Putluri V, Chen F, Nanda S, Bhowmik SK, Terunuma A, Dorsey T, Nardone A, Fu X, Shaw C, Sarkar TR, Schiff R, Lydon JP, O'Malley BW, Ambs S, Das GM, Michailidis G, Sreekumar ANeoplasia (New York, N.Y.)Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance. Neoplasia. 2014 May; 16(5):390-402.Neoplasia2014-05-01T00:00:002014Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance.25048699Kwon OJ, Valdez JM, Zhang L, Zhang B, Wei X, Su Q, Ittmann MM, Creighton CJ, Xin LNature communicationsIncreased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells. Nat Commun. 2014 Jul 22; 5:4416.Nat Commun2014-07-22T00:00:002014Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells.Authorship 5252514Authorship 758601Authorship 557493Authorship 552252Authorship 562431Authorship 594431Authorship 1510644025155756Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, Hacker KE, Bhanot G, Gordenin DA, Chu A, Gunaratne PH, Biehl M, Seth S, Kaipparettu BA, Bristow CA, Donehower LA, Wallen EM, Smith AB, Tickoo SK, Tamboli P, Reuter V, Schmidt LS, Hsieh JJ, Choueiri TK, Hakimi AA, The?Cancer Genome Atlas Research Network, Chin L, Meyerson M, Kucherlapati R, Park WY, Robertson AG, Laird PW, Henske EP, Kwiatkowski DJ, Park PJ, Morgan M, Shuch B, Muzny D, Wheeler DA, Linehan WM, Gibbs RA, Rathmell WK, Creighton CJCancer cellThe somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell. 2014 Sep 08; 26(3):319-330.Cancer Cell2014-08-21T00:00:002014The somatic genomic landscape of chromophobe renal cell carcinoma.Authorship 61432125212826Fu X, Creighton CJ, Biswal NC, Kumar V, Shea M, Herrera S, Contreras A, Gutierrez C, Wang T, Nanda S, Giuliano M, Morrison G, Nardone A, Karlin KL, Westbrook TF, Heiser LM, Anur P, Spellman P, Guichard SM, Smith PD, Davies BR, Klinowska T, Lee AV, Mills GB, Rimawi MF, Hilsenbeck SG, Gray JW, Joshi A, Osborne CK, Schiff RBreast cancer research : BCROvercoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase. Breast Cancer Res. 2014 Sep 11; 16(5):430.Breast Cancer Res2014-09-11T00:00:002014Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.Authorship 869343Authorship 6359814Authorship 87868425333263Yang F, Chen Y, Shen T, Guo D, Dakhova O, Ittmann MM, Creighton CJ, Zhang Y, Dang TD, Rowley DROncotargetStromal TGF-? signaling induces AR activation in prostate cancer. Oncotarget. 2014 Nov 15; 5(21):10854-69.Oncotarget2014-11-15T00:00:002014Stromal TGF-? signaling induces AR activation in prostate cancer.Authorship 972141Authorship 6833312Authorship 982831Authorship 1536037Authorship 698916Authorship 711977Authorship 752095Authorship 772517Authorship 1549064Authorship 1551297Authorship 1556116Authorship 1556765