"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Descriptor ID |
D015398
|
MeSH Number(s) |
G02.111.820 G04.835
|
Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1994 | 12 | 16 | 28 |
1995 | 21 | 30 | 51 |
1996 | 20 | 34 | 54 |
1997 | 24 | 40 | 64 |
1998 | 29 | 39 | 68 |
1999 | 36 | 62 | 98 |
2000 | 44 | 68 | 112 |
2001 | 34 | 65 | 99 |
2002 | 38 | 87 | 125 |
2003 | 70 | 152 | 222 |
2004 | 69 | 155 | 224 |
2005 | 78 | 196 | 274 |
2006 | 106 | 175 | 281 |
2007 | 102 | 191 | 293 |
2008 | 108 | 210 | 318 |
2009 | 94 | 205 | 299 |
2010 | 128 | 274 | 402 |
2011 | 137 | 272 | 409 |
2012 | 124 | 273 | 397 |
2013 | 121 | 295 | 416 |
2014 | 94 | 327 | 421 |
2015 | 88 | 280 | 368 |
2016 | 84 | 270 | 354 |
2017 | 87 | 272 | 359 |
2018 | 68 | 214 | 282 |
2019 | 61 | 215 | 276 |
2020 | 56 | 165 | 221 |
2021 | 41 | 166 | 207 |
2022 | 12 | 57 | 69 |
2023 | 5 | 67 | 72 |
2024 | 4 | 22 | 26 |
To return to the timeline,
click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
-
Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia. Cancer Cell. 2024 Apr 08; 42(4):552-567.e6.
-
Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. 2024 Apr 11; 67(7):5333-5350.
-
The MUC1-HIF-1a signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling. Proc Natl Acad Sci U S A. 2024 Apr 02; 121(14):e2315509121.
-
De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor. Cell Mol Life Sci. 2024 Mar 28; 81(1):153.
-
Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer. Sci Adv. 2024 Mar 29; 10(13):eadk5386.
-
Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy. Elife. 2024 Mar 27; 12.
-
The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity. Molecules. 2024 Mar 14; 29(6).
-
Translational genetics identifies a phosphorylation switch in CARD9 required for innate inflammatory responses. Cell Rep. 2024 Mar 26; 43(3):113944.
-
Unlocking c-MET: A comprehensive journey into targeted therapies for breast cancer. Cancer Lett. 2024 Apr 28; 588:216780.
-
Nutrient Sensing in Macrophages Linked to Reorganized Tumor Vasculature. Cancer Res. 2024 03 04; 84(5):650-651.