Proto-Oncogene Proteins c-akt
"Proto-Oncogene Proteins c-akt" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Descriptor ID |
D051057
|
MeSH Number(s) |
D08.811.913.696.620.682.700.755 D12.776.476.565 D12.776.624.664.700.168
|
Concept/Terms |
Proto-Oncogene Proteins c-akt- Proto-Oncogene Proteins c-akt
- Proto Oncogene Proteins c akt
- c-akt, Proto-Oncogene Proteins
- Protein Kinase B
- Proto-Oncogene Protein RAC
- Proto Oncogene Protein RAC
- RAC, Proto-Oncogene Protein
- Proto-Oncogene Protein Akt
- Akt, Proto-Oncogene Protein
- Proto Oncogene Protein Akt
- Rac Protein Kinase
- akt Proto-Oncogene Protein
- Protein, akt Proto-Oncogene
- Proto-Oncogene Protein, akt
- akt Proto Oncogene Protein
- RAC-PK Protein
- RAC PK Protein
- Related to A and C-Protein
- Related to A and C Protein
- c-akt Proto-Oncogene Protein
- Protein, c-akt Proto-Oncogene
- Proto-Oncogene Protein, c-akt
- c akt Proto Oncogene Protein
- c-akt Protein
- Protein-Serine-Threonine Kinase (Rac)
Proto-Oncogene Proteins c-akt1- Proto-Oncogene Proteins c-akt1
- Proteins c-akt1, Proto-Oncogene
- Proto Oncogene Proteins c akt1
- c-akt1, Proto-Oncogene Proteins
- AKT1 Protein Kinase
- Rac-PK alpha Protein
- Rac PK alpha Protein
- alpha Protein, Rac-PK
- Protein Kinase B alpha
- Akt-alpha Protein
- Akt alpha Protein
Proto-Oncogene Proteins c-akt2- Proto-Oncogene Proteins c-akt2
- Proteins c-akt2, Proto-Oncogene
- Proto Oncogene Proteins c akt2
- c-akt2, Proto-Oncogene Proteins
- Protein Kinase B beta
- Rac-PK beta Protein
- Rac PK beta Protein
- AKT2 Protein Kinase
- Akt-beta Protein
- Akt beta Protein
Proto-Oncogene Proteins c-akt3- Proto-Oncogene Proteins c-akt3
- Proteins c-akt3, Proto-Oncogene
- Proto Oncogene Proteins c akt3
- c-akt3, Proto-Oncogene Proteins
- Akt-gamma Protein
- Akt gamma Protein
- AKT3 Protein Kinase
- Protein Kinase B gamma
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-akt".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-akt".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-akt" by people in this website by year, and whether "Proto-Oncogene Proteins c-akt" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1997 | 0 | 1 | 1 |
1998 | 0 | 2 | 2 |
1999 | 0 | 1 | 1 |
2000 | 0 | 9 | 9 |
2001 | 0 | 8 | 8 |
2002 | 0 | 16 | 16 |
2003 | 0 | 32 | 32 |
2004 | 1 | 44 | 45 |
2005 | 7 | 38 | 45 |
2006 | 30 | 31 | 61 |
2007 | 23 | 35 | 58 |
2008 | 19 | 33 | 52 |
2009 | 22 | 24 | 46 |
2010 | 16 | 41 | 57 |
2011 | 29 | 32 | 61 |
2012 | 21 | 40 | 61 |
2013 | 21 | 38 | 59 |
2014 | 18 | 44 | 62 |
2015 | 15 | 31 | 46 |
2016 | 7 | 22 | 29 |
2017 | 20 | 34 | 54 |
2018 | 8 | 18 | 26 |
2019 | 9 | 16 | 25 |
2020 | 5 | 20 | 25 |
2021 | 12 | 9 | 21 |
2022 | 1 | 14 | 15 |
2023 | 2 | 9 | 11 |
2024 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Proto-Oncogene Proteins c-akt" by people in Profiles.
-
Phase I Study of mTORC1/2 Inhibitor Sapanisertib (CB-228/TAK-228) in Combination with Metformin in Patients with mTOR/AKT/PI3K Pathway Alterations and Advanced Solid Malignancies. Cancer Res Commun. 2024 02 12; 4(2):378-387.
-
Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors. Cancer Res Commun. 2023 12 28; 3(12):2623-2639.
-
Unlocking the miRNA-34a-5p/TGF-? and HMGB1/PI3K/Akt/mTOR crosstalk participate in the enhanced cardiac protection of liraglutide against isoproterenol-induced acute myocardial injury rat model. Int Immunopharmacol. 2024 Jan 25; 127:111369.
-
MiR126-targeted-nanoparticles combined with PI3K/AKT inhibitor as a new strategy to overcome melanoma resistance. Mol Ther. 2024 Jan 03; 32(1):152-167.
-
Irisin ameliorates diabetic kidney disease by restoring autophagy in podocytes. FASEB J. 2023 10; 37(10):e23175.
-
Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway. IUBMB Life. 2024 Mar; 76(3):140-160.
-
Proteogenomic insights suggest druggable pathways in endometrial carcinoma. Cancer Cell. 2023 09 11; 41(9):1586-1605.e15.
-
Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy. PLoS Biol. 2023 08; 21(8):e3002227.
-
3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib. Commun Biol. 2023 05 11; 6(1):509.
-
Metrnl deficiency retards skin wound healing in mice by inhibiting AKT/eNOS signaling and angiogenesis. Acta Pharmacol Sin. 2023 Sep; 44(9):1790-1800.