"Myostatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A growth differentiation factor that is a potent inhibitor of SKELETAL MUSCLE growth. It may play a role in the regulation of MYOGENESIS and in muscle maintenance during adulthood.
| Descriptor ID |
D055435
|
| MeSH Number(s) |
D12.644.276.954.300.925 D12.776.467.942.300.925 D23.529.942.300.925
|
| Concept/Terms |
Myostatin- Myostatin
- Growth Differentiation Factor 8
- GDF-8
|
Below are MeSH descriptors whose meaning is more general than "Myostatin".
Below are MeSH descriptors whose meaning is more specific than "Myostatin".
This graph shows the total number of publications written about "Myostatin" by people in this website by year, and whether "Myostatin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 2 | 0 | 2 |
| 2012 | 1 | 1 | 2 |
| 2013 | 3 | 1 | 4 |
| 2015 | 1 | 1 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Myostatin" by people in Profiles.
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Heparin-mediated dimerization of follistatin. Exp Biol Med (Maywood). 2021 02; 246(4):467-482.
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IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice. J Endocrinol. 2017 Aug; 234(2):187-200.
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Suppression of muscle wasting by the plant-derived compound ursolic acid in a model of chronic kidney disease. J Cachexia Sarcopenia Muscle. 2017 Apr; 8(2):327-341.
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The pathway to muscle fibrosis depends on myostatin stimulating the differentiation of fibro/adipogenic progenitor cells in chronic kidney disease. Kidney Int. 2017 01; 91(1):119-128.
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Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues. Int J Obes (Lond). 2016 Mar; 40(3):434-442.
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The role of myostatin and activin receptor IIB in the regulation of unloading-induced myofiber type-specific skeletal muscle atrophy. J Appl Physiol (1985). 2015 Sep 15; 119(6):633-42.
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Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem. 2015 Apr 24; 290(17):11177-87.
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Sarcopenic obesity: how do we treat it? Curr Opin Endocrinol Diabetes Obes. 2013 Oct; 20(5):412-9.
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Stat3 activation links a C/EBPd to myostatin pathway to stimulate loss of muscle mass. Cell Metab. 2013 Sep 03; 18(3):368-79.
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Myostatin/activin pathway antagonism: molecular basis and therapeutic potential. Int J Biochem Cell Biol. 2013 Oct; 45(10):2333-47.