Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
| Descriptor ID |
D013329
|
| MeSH Number(s) |
G02.111.830 G07.690.773.997
|
| Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
|
Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 24 | 24 |
| 1995 | 0 | 22 | 22 |
| 1996 | 0 | 24 | 24 |
| 1997 | 0 | 13 | 13 |
| 1998 | 0 | 11 | 11 |
| 1999 | 0 | 14 | 14 |
| 2000 | 0 | 16 | 16 |
| 2001 | 0 | 10 | 10 |
| 2002 | 1 | 16 | 17 |
| 2003 | 1 | 23 | 24 |
| 2004 | 0 | 18 | 18 |
| 2005 | 0 | 22 | 22 |
| 2006 | 1 | 29 | 30 |
| 2007 | 0 | 21 | 21 |
| 2008 | 0 | 19 | 19 |
| 2009 | 0 | 28 | 28 |
| 2010 | 0 | 21 | 21 |
| 2011 | 0 | 21 | 21 |
| 2012 | 0 | 30 | 30 |
| 2013 | 0 | 22 | 22 |
| 2014 | 0 | 20 | 20 |
| 2015 | 0 | 25 | 25 |
| 2016 | 0 | 12 | 12 |
| 2017 | 0 | 20 | 20 |
| 2018 | 0 | 15 | 15 |
| 2019 | 0 | 13 | 13 |
| 2020 | 0 | 21 | 21 |
| 2021 | 0 | 23 | 23 |
| 2022 | 0 | 4 | 4 |
| 2023 | 0 | 3 | 3 |
| 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. 2024 Apr 11; 67(7):5333-5350.
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Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1 mutation carriers. Cell Rep. 2024 Feb 27; 43(2):113803.
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Quinazolinone Compounds Have Potent Antiviral Activity against Zika and Dengue Virus. J Med Chem. 2023 08 10; 66(15):10746-10760.
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First-in-Class Dual Targeting Compounds for the Management of Seizures in Glucose Transporter Type 1 Deficiency Syndrome. J Med Chem. 2023 07 27; 66(14):10010-10026.
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Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition. Bioorg Med Chem Lett. 2023 06 15; 90:129328.
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Nonhydrolyzable d-phenylalanine-benzoxazole derivatives retain antitubercular activity. Bioorg Med Chem Lett. 2023 01 15; 80:129116.
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Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections. Proc Natl Acad Sci U S A. 2022 05 31; 119(22):e2122506119.
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Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP. Eur J Med Chem. 2022 Jul 05; 237:114407.
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Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology. J Biol Chem. 2022 03; 298(3):101720.
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Targeting NLRP3 signaling by a novel-designed sulfonylurea compound for inhibition of microglial inflammation. Bioorg Med Chem. 2022 03 15; 58:116645.