"DNA Repair" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Descriptor ID |
D004260
|
MeSH Number(s) |
G02.111.222 G05.219
|
Concept/Terms |
Base Excision Repair- Base Excision Repair
- Base Excision Repairs
- Excision Repair, Base
- Repair, Base Excision
- Repairs, Base Excision
|
Below are MeSH descriptors whose meaning is more general than "DNA Repair".
Below are MeSH descriptors whose meaning is more specific than "DNA Repair".
This graph shows the total number of publications written about "DNA Repair" by people in this website by year, and whether "DNA Repair" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 18 | 5 | 23 |
1995 | 18 | 5 | 23 |
1996 | 11 | 6 | 17 |
1997 | 23 | 7 | 30 |
1998 | 13 | 10 | 23 |
1999 | 24 | 10 | 34 |
2000 | 28 | 15 | 43 |
2001 | 15 | 10 | 25 |
2002 | 14 | 14 | 28 |
2003 | 23 | 14 | 37 |
2004 | 21 | 33 | 54 |
2005 | 25 | 26 | 51 |
2006 | 26 | 17 | 43 |
2007 | 32 | 26 | 58 |
2008 | 22 | 23 | 45 |
2009 | 23 | 26 | 49 |
2010 | 42 | 22 | 64 |
2011 | 19 | 30 | 49 |
2012 | 27 | 26 | 53 |
2013 | 17 | 19 | 36 |
2014 | 20 | 23 | 43 |
2015 | 26 | 27 | 53 |
2016 | 7 | 23 | 30 |
2017 | 17 | 23 | 40 |
2018 | 9 | 18 | 27 |
2019 | 13 | 21 | 34 |
2020 | 12 | 14 | 26 |
2021 | 16 | 19 | 35 |
2022 | 7 | 15 | 22 |
2023 | 4 | 12 | 16 |
2024 | 0 | 5 | 5 |
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Below are the most recent publications written about "DNA Repair" by people in Profiles.
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Targeting ATR in patients with cancer. Nat Rev Clin Oncol. 2024 Apr; 21(4):278-293.
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Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. Sci Transl Med. 2024 Feb 14; 16(734):eadj5962.
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Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma. Nat Commun. 2024 Feb 08; 15(1):1203.
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GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress. Cancer Discov. 2024 01 12; 14(1):158-175.
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Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence. Mol Cancer Ther. 2024 Jan 03; 23(1):24-34.
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Life, the genome and everything. J Bacteriol. 2023 12 19; 205(12):e0027223.
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Germline Sequencing Analysis to Inform Clinical Gene Panel Testing for Aggressive Prostate Cancer. JAMA Oncol. 2023 Nov 01; 9(11):1514-1524.
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SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. Cell Stem Cell. 2023 11 02; 30(11):1503-1519.e8.
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Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs. Nat Struct Mol Biol. 2023 10; 30(10):1456-1467.
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TGF? signaling links early life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells. Cell Mol Life Sci. 2023 Sep 09; 80(10):288.