Protein Tyrosine Phosphatase, Non-Receptor Type 11
"Protein Tyrosine Phosphatase, Non-Receptor Type 11" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of non-receptor protein tyrosine phosphatases that contain two SRC HOMOLOGY DOMAINS. Mutations in the gene for protein tyrosine phosphatase, non-receptor type 11 are associated with NOONAN SYNDROME.
| Descriptor ID |
D054592
|
| MeSH Number(s) |
D08.811.277.352.650.775.300.800 D08.811.277.352.650.775.700.800 D12.644.360.585.800 D12.776.476.564.800 D12.776.476.800.800
|
| Concept/Terms |
Protein Tyrosine Phosphatase, Non-Receptor Type 11- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non Receptor Type 11
- SHPTP2
- Phosphotyrosine Phosphatase Syp
- SHP-2 Protein-Tyrosine Phosphatase
- Protein Tyrosine Phosphatase PTP3
- Shp-2 Tyrosine Phosphatase
- Shp 2 Tyrosine Phosphatase
- Tyrosine Phosphatase, Shp-2
- SHP2 Phosphatase
- Phosphatase, SHP2
- Protein-Tyrosine-Phosphatase 2C
- Protein Tyrosine Phosphatase 2C
|
Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 11".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Phosphoric Monoester Hydrolases [D08.811.277.352.650]
- Protein Tyrosine Phosphatases [D08.811.277.352.650.775]
- Protein Tyrosine Phosphatases, Non-Receptor [D08.811.277.352.650.775.300]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D08.811.277.352.650.775.300.800]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D08.811.277.352.650.775.700]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D08.811.277.352.650.775.700.800]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Protein Tyrosine Phosphatases, Non-Receptor [D12.644.360.585]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D12.644.360.585.800]
- Proteins [D12.776]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Protein Tyrosine Phosphatases, Non-Receptor [D12.776.476.564]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D12.776.476.564.800]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.776.476.800]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D12.776.476.800.800]
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 11".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 11" by people in this website by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 11" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 3 | 0 | 3 |
| 2010 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 2 | 3 |
| 2020 | 3 | 0 | 3 |
| 2021 | 4 | 1 | 5 |
| 2022 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 11" by people in Profiles.
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Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state. Mol Cell. 2022 03 17; 82(6):1089-1106.e12.
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Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J Med Chem. 2021 10 28; 64(20):15141-15169.
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Targeted Degradation of the Oncogenic Phosphatase SHP2. Biochemistry. 2021 08 31; 60(34):2593-2609.
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Gliosarcoma vs. glioblastoma: a retrospective case series using molecular profiling. BMC Neurol. 2021 Jun 23; 21(1):231.
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Grb2 binding induces phosphorylation-independent activation of Shp2. Commun Biol. 2021 04 01; 4(1):437.
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Proteogenomic and metabolomic characterization of human glioblastoma. Cancer Cell. 2021 04 12; 39(4):509-528.e20.
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Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res. 2020 11 01; 80(21):4840-4853.
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The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia. Leukemia. 2021 03; 35(3):691-700.
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Allosteric Inhibition of SHP2 Stimulates Antitumor Immunity by Transforming the Immunosuppressive Environment. Cancer Res. 2020 07 01; 80(13):2889-2902.
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Prognostic impact of RAS-pathway mutations in patients with myelofibrosis. Leukemia. 2020 03; 34(3):799-810.