"Leptin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
| Descriptor ID |
D020738
|
| MeSH Number(s) |
D06.472.699.042.500 D12.644.276.024.500 D12.644.548.011.500 D12.776.467.024.500 D23.529.024.500
|
| Concept/Terms |
Leptin- Leptin
- Obese Protein
- Obese Gene Product
- Gene Product, Obese
- Ob Gene Product
- Gene Product, Ob
- Ob Protein
|
Below are MeSH descriptors whose meaning is more general than "Leptin".
Below are MeSH descriptors whose meaning is more specific than "Leptin".
This graph shows the total number of publications written about "Leptin" by people in this website by year, and whether "Leptin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 7 | 7 |
| 1999 | 1 | 3 | 4 |
| 2000 | 3 | 2 | 5 |
| 2001 | 3 | 3 | 6 |
| 2002 | 2 | 2 | 4 |
| 2003 | 2 | 1 | 3 |
| 2004 | 5 | 2 | 7 |
| 2005 | 3 | 4 | 7 |
| 2006 | 2 | 6 | 8 |
| 2007 | 1 | 4 | 5 |
| 2008 | 2 | 6 | 8 |
| 2009 | 3 | 3 | 6 |
| 2010 | 8 | 11 | 19 |
| 2011 | 5 | 5 | 10 |
| 2012 | 7 | 4 | 11 |
| 2013 | 5 | 8 | 13 |
| 2014 | 4 | 5 | 9 |
| 2015 | 5 | 6 | 11 |
| 2016 | 8 | 4 | 12 |
| 2017 | 1 | 8 | 9 |
| 2018 | 2 | 2 | 4 |
| 2019 | 2 | 4 | 6 |
| 2020 | 6 | 3 | 9 |
| 2021 | 1 | 2 | 3 |
| 2022 | 1 | 2 | 3 |
| 2023 | 3 | 2 | 5 |
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Below are the most recent publications written about "Leptin" by people in Profiles.
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Leptin Decreases Gluconeogenesis and Gluconeogenic Substrate Availability in Patients With Lipodystrophy. J Clin Endocrinol Metab. 2023 Dec 21; 109(1):e209-e215.
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Baseline leptin predicts response to metformin in adolescents with type 1 diabetes and increased body mass index. Diabetes Obes Metab. 2023 11; 25(11):3420-3423.
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The Metreleptin Effectiveness and Safety Registry (MEASuRE): concept, design and challenges. Orphanet J Rare Dis. 2023 05 26; 18(1):127.
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Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity. Elife. 2023 04 12; 12.
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Hypothalamic Grb10 enhances leptin signalling and promotes weight loss. Nat Metab. 2023 01; 5(1):147-164.
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Baseline Testosterone Predicts Body Composition and Metabolic Response to Testosterone Therapy. Front Endocrinol (Lausanne). 2022; 13:915309.
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Inflammatory profile associated with insulin resistance in non-overweight versus overweight people living with HIV in Pune, Western India. Diabetes Metab Syndr. 2022 Jul; 16(7):102551.
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Changes in adiponectin:leptin ratio among older adults with obesity following a 12-month exercise and diet intervention. Nutr Diabetes. 2022 06 02; 12(1):30.
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Leptin Enhances Hepatic Fibrosis and Inflammation in a Mouse Model of Cholestasis. Am J Pathol. 2022 03; 192(3):484-502.
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Does the Epigenome Hold Clues to Leptin-associated Hypertension in Obesity? Am J Respir Cell Mol Biol. 2021 08; 65(2):132-133.