Otx Transcription Factors
"Otx Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of VERTEBRATE homeodomain proteins that share homology with orthodenticle protein, Drosophila. They regulate GENETIC TRANSCRIPTION and play an important role in EMBRYONIC DEVELOPMENT of the BRAIN.
| Descriptor ID |
D051857
|
| MeSH Number(s) |
D12.776.260.400.718 D12.776.930.650
|
| Concept/Terms |
Otx Transcription Factors- Otx Transcription Factors
- Transcription Factors, Otx
- Otx Homeodomain Proteins
- Homeodomain Proteins, Otx
- Orthodenticle Homolog Homeodomain Proteins
|
Below are MeSH descriptors whose meaning is more general than "Otx Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "Otx Transcription Factors".
This graph shows the total number of publications written about "Otx Transcription Factors" by people in this website by year, and whether "Otx Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Otx Transcription Factors" by people in Profiles.
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Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 2022 09; 609(7929):1021-1028.
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An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate. Nat Commun. 2020 07 20; 11(1):3627.
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Characterization of a novel OTX2-driven stem cell program in Group 3 and Group 4 medulloblastoma. Mol Oncol. 2018 04; 12(4):495-513.
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Genitourinary defects associated with genomic deletions in 2p15 encompassing OTX1. PLoS One. 2014; 9(9):e107028.
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Ectopic Mitf in the embryonic chick retina by co-transfection of ?-catenin and Otx2. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5328-35.
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COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development. 2010 Mar; 137(5):725-34.
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Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression. Development. 2009 Aug; 136(15):2505-10.
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Branchiootorenal syndrome and oculoauriculovertebral spectrum features associated with duplication of SIX1, SIX6, and OTX2 resulting from a complex chromosomal rearrangement. Am J Med Genet A. 2008 Oct 01; 146A(19):2480-9.
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Generation and maintenance of Dmbx1 gene-targeted mutant alleles. Mamm Genome. 2006 Jul; 17(7):744-50.
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Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer. Dev Biol. 2006 May 01; 293(1):13-24.