"gamma-Glutamyl Hydrolase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Catalyzes the hydrolysis of pteroylpolyglutamic acids in gamma linkage to pterolylmonoglutamic acid and free glutamic acid. EC 3.4.19.9.
| Descriptor ID |
D011623
|
| MeSH Number(s) |
D08.811.277.656.350.245.280
|
| Concept/Terms |
gamma-Glutamyl Hydrolase- gamma-Glutamyl Hydrolase
- gamma Glutamyl Hydrolase
- Folylpolyglutamate Hydrolase
- Pteroyl Polyglutamate Hydrolase
- Carboxypeptidase G
- Folyl Poly-gamma-Glutamate Carboxypeptidase
- Folacin Conjugase
- Folate Conjugase
- Folate Hydrolyzing Enzyme
- Folyl Conjugate Synthetase
- Folyl Polyglutamate Cleavage Enzyme
- Conjugase
|
Below are MeSH descriptors whose meaning is more general than "gamma-Glutamyl Hydrolase".
Below are MeSH descriptors whose meaning is more specific than "gamma-Glutamyl Hydrolase".
This graph shows the total number of publications written about "gamma-Glutamyl Hydrolase" by people in this website by year, and whether "gamma-Glutamyl Hydrolase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "gamma-Glutamyl Hydrolase" by people in Profiles.
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Novel risk factors for glucarpidase use in pediatric acute lymphoblastic leukemia: Hispanic ethnicity, age, and the ABCC4 gene. Pediatr Blood Cancer. 2021 08; 68(8):e29036.
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Hispanic ethnicity as a risk factor for requiring glucarpidase rescue in pediatric patients receiving high-dose methotrexate. Am J Hematol. 2018 02; 93(2):E40-E42.
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Coupling of conjugating enzymes and efflux transporters: impact on bioavailability and drug interactions. Curr Drug Metab. 2005 Oct; 6(5):455-68.
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Treatment of accidental intrathecal methotrexate overdose with intrathecal carboxypeptidase G2. J Natl Cancer Inst. 2004 Oct 20; 96(20):1557-9.
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Methotrexate pharmacokinetics following administration of recombinant carboxypeptidase-G2 in rhesus monkeys. J Clin Oncol. 1992 Aug; 10(8):1359-64.
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Rescue of experimental intrathecal methotrexate overdose with carboxypeptidase-G2. J Clin Oncol. 1991 Apr; 9(4):670-4.