"DNA Helicases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
| Descriptor ID |
D004265
|
| MeSH Number(s) |
D08.811.277.040.025.159 D08.811.399.340
|
| Concept/Terms |
DNA Helicases- DNA Helicases
- Helicases, DNA
- DNA Unwinding Proteins
- Unwinding Proteins, DNA
ATP-Dependent DNA Helicases- ATP-Dependent DNA Helicases
- ATP Dependent DNA Helicases
- DNA Helicases, ATP-Dependent
- Helicases, ATP-Dependent DNA
|
Below are MeSH descriptors whose meaning is more general than "DNA Helicases".
Below are MeSH descriptors whose meaning is more specific than "DNA Helicases".
This graph shows the total number of publications written about "DNA Helicases" by people in this website by year, and whether "DNA Helicases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 1 | 1 | 2 |
| 1996 | 2 | 1 | 3 |
| 1997 | 5 | 2 | 7 |
| 1998 | 5 | 0 | 5 |
| 1999 | 4 | 0 | 4 |
| 2000 | 4 | 2 | 6 |
| 2001 | 5 | 1 | 6 |
| 2002 | 7 | 1 | 8 |
| 2003 | 8 | 2 | 10 |
| 2004 | 3 | 2 | 5 |
| 2005 | 6 | 6 | 12 |
| 2006 | 6 | 4 | 10 |
| 2007 | 1 | 4 | 5 |
| 2008 | 3 | 1 | 4 |
| 2009 | 3 | 5 | 8 |
| 2010 | 6 | 4 | 10 |
| 2011 | 11 | 3 | 14 |
| 2012 | 6 | 5 | 11 |
| 2013 | 10 | 5 | 15 |
| 2014 | 4 | 6 | 10 |
| 2015 | 2 | 4 | 6 |
| 2016 | 8 | 6 | 14 |
| 2017 | 8 | 7 | 15 |
| 2018 | 3 | 3 | 6 |
| 2019 | 3 | 4 | 7 |
| 2020 | 1 | 5 | 6 |
| 2021 | 2 | 4 | 6 |
| 2022 | 5 | 8 | 13 |
| 2023 | 1 | 13 | 14 |
| 2024 | 0 | 3 | 3 |
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Below are the most recent publications written about "DNA Helicases" by people in Profiles.
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SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions. Cancer Cell. 2024 Apr 08; 42(4):605-622.e11.
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High Clinical Exome Sequencing Diagnostic Rates and Novel Phenotypic Expansions for Nonisolated Microphthalmia, Anophthalmia, and Coloboma. Invest Ophthalmol Vis Sci. 2024 Mar 05; 65(3):25.
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Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma. Nat Commun. 2024 Feb 08; 15(1):1203.
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Life, the genome and everything. J Bacteriol. 2023 12 19; 205(12):e0027223.
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Tazemetostat for tumors harboring SMARCB1/SMARCA4 or EZH2 alterations: results from NCI-COG pediatric MATCH APEC1621C. J Natl Cancer Inst. 2023 11 08; 115(11):1355-1363.
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DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors. Cancer Res Commun. 2023 10 16; 3(10):2096-2112.
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Monoallelic variation in DHX9, the gene encoding the DExH-box helicase DHX9, underlies neurodevelopment disorders and Charcot-Marie-Tooth disease. Am J Hum Genet. 2023 08 03; 110(8):1394-1413.
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Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC. Cancer Discov. 2023 07 07; 13(7):1556-1571.
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Facial analytics based on a coordinate extrapolation system (zFACE) for morphometric phenotyping of developing zebrafish. Dis Model Mech. 2023 06 01; 16(6).
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Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases. Nat Commun. 2023 05 13; 14(1):2758.