"Philadelphia Chromosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
Descriptor ID |
D010677
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MeSH Number(s) |
A11.284.187.520.300.325.345.500 A11.284.187.520.300.505.515.500 C23.550.210.870.680 G05.360.162.520.300.325.345.700 G05.360.162.520.300.505.515.700 G05.365.590.175.870.680
|
Concept/Terms |
Philadelphia Chromosome- Philadelphia Chromosome
- Chromosome, Philadelphia
- Ph 1 Chromosome
- 1 Chromosomes, Ph
- Chromosome, Ph 1
- Chromosomes, Ph 1
- Ph 1 Chromosomes
- Ph1 Chromosome
- Chromosome, Ph1
- Chromosomes, Ph1
- Ph1 Chromosomes
|
Below are MeSH descriptors whose meaning is more general than "Philadelphia Chromosome".
- Anatomy [A]
- Cells [A11]
- Cellular Structures [A11.284]
- Chromosomes [A11.284.187]
- Chromosomes, Mammalian [A11.284.187.520]
- Chromosomes, Human [A11.284.187.520.300]
- Chromosomes, Human, 6-12 and X [A11.284.187.520.300.325]
- Chromosomes, Human, Pair 9 [A11.284.187.520.300.325.345]
- Philadelphia Chromosome [A11.284.187.520.300.325.345.500]
- Chromosomes, Human, 21-22 and Y [A11.284.187.520.300.505]
- Chromosomes, Human, Pair 22 [A11.284.187.520.300.505.515]
- Philadelphia Chromosome [A11.284.187.520.300.505.515.500]
- Diseases [C]
- Pathological Conditions, Signs and Symptoms [C23]
- Pathologic Processes [C23.550]
- Chromosome Aberrations [C23.550.210]
- Translocation, Genetic [C23.550.210.870]
- Philadelphia Chromosome [C23.550.210.870.680]
- Biological Sciences [G]
- Genetic Phenomena [G05]
- Genetic Structures [G05.360]
- Chromosomes [G05.360.162]
- Chromosomes, Mammalian [G05.360.162.520]
- Chromosomes, Human [G05.360.162.520.300]
- Chromosomes, Human, 6-12 and X [G05.360.162.520.300.325]
- Chromosomes, Human, Pair 9 [G05.360.162.520.300.325.345]
- Philadelphia Chromosome [G05.360.162.520.300.325.345.700]
- Chromosomes, Human, 21-22 and Y [G05.360.162.520.300.505]
- Chromosomes, Human, Pair 22 [G05.360.162.520.300.505.515]
- Philadelphia Chromosome [G05.360.162.520.300.505.515.700]
- Genetic Variation [G05.365]
- Mutation [G05.365.590]
- Chromosome Aberrations [G05.365.590.175]
- Translocation, Genetic [G05.365.590.175.870]
- Philadelphia Chromosome [G05.365.590.175.870.680]
Below are MeSH descriptors whose meaning is more specific than "Philadelphia Chromosome".
This graph shows the total number of publications written about "Philadelphia Chromosome" by people in this website by year, and whether "Philadelphia Chromosome" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 3 | 3 | 6 |
1995 | 3 | 0 | 3 |
1996 | 2 | 1 | 3 |
1997 | 2 | 2 | 4 |
1998 | 4 | 2 | 6 |
1999 | 1 | 7 | 8 |
2000 | 2 | 3 | 5 |
2001 | 1 | 1 | 2 |
2002 | 4 | 3 | 7 |
2003 | 2 | 6 | 8 |
2004 | 2 | 2 | 4 |
2005 | 1 | 2 | 3 |
2006 | 1 | 5 | 6 |
2007 | 3 | 4 | 7 |
2008 | 3 | 4 | 7 |
2009 | 1 | 3 | 4 |
2010 | 1 | 2 | 3 |
2011 | 3 | 4 | 7 |
2012 | 2 | 2 | 4 |
2013 | 3 | 0 | 3 |
2014 | 3 | 5 | 8 |
2015 | 4 | 5 | 9 |
2016 | 9 | 6 | 15 |
2017 | 7 | 8 | 15 |
2018 | 6 | 6 | 12 |
2019 | 2 | 5 | 7 |
2020 | 4 | 7 | 11 |
2021 | 3 | 13 | 16 |
2022 | 3 | 4 | 7 |
2023 | 2 | 8 | 10 |
To return to the timeline,
click here.
Below are the most recent publications written about "Philadelphia Chromosome" by people in Profiles.
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Dose-Dense Mini-Hyper-CVD, Inotuzumab Ozogamicin and Blinatumomab Achieves Rapid MRD-Negativity in Philadelphia Chromosome-Negative B-cell Acute Lymphoblastic Leukemia. Clin Lymphoma Myeloma Leuk. 2024 04; 24(4):e168-e173.
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Cross-intolerance with bosutinib after prior tyrosine kinase inhibitors for Philadelphia chromosome-positive leukemia: long-term analysis of a phase I/II study. Haematologica. 2023 Dec 01; 108(12):3454-3459.
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Outcome of Philadelphia chromosome-positive chronic myeloid leukemia in the United States since the introduction of imatinib therapy-The Surveillance, Epidemiology, and End Results database, 2000-2019. Cancer. 2023 12 01; 129(23):3805-3814.
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Dasatinib with intensive chemotherapy in de novo paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (CA180-372/COG AALL1122): a single-arm, multicentre, phase 2 trial. Lancet Haematol. 2023 Jul; 10(7):e510-e520.
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SOHO State of the Art Updates and Next Questions | Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia in Adults: Therapeutic Options and Challenges in 2023. Clin Lymphoma Myeloma Leuk. 2023 11; 23(11):779-785.
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Mini-hyper-CVD plus inotuzumab ozogamicin, with or without blinatumomab, in the subgroup of older patients with newly diagnosed Philadelphia chromosome-negative B-cell acute lymphocytic leukaemia: long-term results of an open-label phase 2 trial. Lancet Haematol. 2023 Jun; 10(6):e433-e444.
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The evolution of acute lymphoblastic leukemia research and therapy at MD Anderson over four decades. J Hematol Oncol. 2023 03 16; 16(1):22.
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The emerging use of chemotherapy-free regimens in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia. Clin Adv Hematol Oncol. 2023 Feb; 21(2):68-75.
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A balancing act: Blinatumomab use in a rare occurrence of Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia in an adolescent patient with Down syndrome. Pediatr Blood Cancer. 2023 05; 70(5):e30191.
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Frontline combination of ponatinib and hyper-CVAD in Philadelphia chromosome-positive acute lymphoblastic leukemia: 80-months follow-up results. Am J Hematol. 2023 03; 98(3):493-501.