Clinical Trials, Phase I as Topic
"Clinical Trials, Phase I as Topic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.
Descriptor ID |
D017321
|
MeSH Number(s) |
E05.318.760.250.500.200 N05.715.360.775.088.500.200 N06.850.520.450.250.250.200
|
Concept/Terms |
Microdosing Trials, Human- Microdosing Trials, Human
- Human Microdosing Trial
- Microdosing Trial, Human
- Trial, Human Microdosing
- Trials, Human Microdosing
- Human Microdosing Trials
|
Below are MeSH descriptors whose meaning is more general than "Clinical Trials, Phase I as Topic".
Below are MeSH descriptors whose meaning is more specific than "Clinical Trials, Phase I as Topic".
This graph shows the total number of publications written about "Clinical Trials, Phase I as Topic" by people in this website by year, and whether "Clinical Trials, Phase I as Topic" was a major or minor topic of these publications.
To see the data from this visualization as text,
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Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 4 | 4 |
1995 | 0 | 1 | 1 |
1996 | 1 | 1 | 2 |
1997 | 0 | 4 | 4 |
1998 | 1 | 1 | 2 |
1999 | 1 | 3 | 4 |
2000 | 0 | 2 | 2 |
2001 | 1 | 9 | 10 |
2002 | 0 | 3 | 3 |
2003 | 2 | 6 | 8 |
2004 | 1 | 5 | 6 |
2005 | 2 | 4 | 6 |
2006 | 2 | 7 | 9 |
2007 | 5 | 5 | 10 |
2008 | 3 | 2 | 5 |
2009 | 9 | 3 | 12 |
2010 | 6 | 6 | 12 |
2011 | 4 | 10 | 14 |
2012 | 5 | 9 | 14 |
2013 | 7 | 7 | 14 |
2014 | 4 | 9 | 13 |
2015 | 6 | 7 | 13 |
2016 | 3 | 15 | 18 |
2017 | 1 | 4 | 5 |
2018 | 6 | 4 | 10 |
2019 | 4 | 8 | 12 |
2020 | 2 | 10 | 12 |
2021 | 0 | 8 | 8 |
2022 | 1 | 7 | 8 |
2023 | 0 | 1 | 1 |
2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Clinical Trials, Phase I as Topic" by people in Profiles.
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Clinical management, monitoring, and prophylaxis of adverse events of special interest associated with datopotamab deruxtecan. Cancer Treat Rev. 2024 Apr; 125:102720.
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A generalized phase 1-2-3 design integrating dose optimization with confirmatory treatment comparison. Biometrics. 2024 Jan 29; 80(1).
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Tisotumab vedotin in recurrent or metastatic cervical cancer. Curr Probl Cancer. 2023 06; 47(3):100952.
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Early drug development in solid tumours: analysis of National Cancer Institute-sponsored phase 1 trials. Lancet. 2022 08 13; 400(10351):512-521.
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BETA PRIME: Phase I study of AdAPT-001 as monotherapy and combined with a checkpoint inhibitor in superficially accessible, treatment-refractory solid tumors. Future Oncol. 2022 Sep; 18(29):3245-3254.
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Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma. Nat Med. 2022 08; 28(8):1599-1611.
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Clinical characteristics and outcomes of phase I cancer patients with CCNE1 amplification: MD Anderson experiences. Sci Rep. 2022 05 24; 12(1):8701.
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Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma. Eur J Endocrinol. 2022 Apr 29; 186(6):631-643.
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Remote ischemic conditioning in necrotizing enterocolitis: study protocol of a multi-center phase II feasibility randomized controlled trial. Pediatr Surg Int. 2022 May; 38(5):679-694.
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TITE-BOIN12: A Bayesian phase I/II trial design to find the optimal biological dose with late-onset toxicity and efficacy. Stat Med. 2022 05 20; 41(11):1918-1931.