"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Descriptor ID |
D018345
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MeSH Number(s) |
B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
|
Concept/Terms |
Mice, Knockout- Mice, Knockout
- Mice, Knock-out
- Knock-out Mice
- Mice, Knock out
- Mouse, Knockout
- Knockout Mouse
- Knockout Mice
|
Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".
Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".
This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 1 | 7 | 8 |
1995 | 0 | 5 | 5 |
1996 | 0 | 14 | 14 |
1997 | 2 | 22 | 24 |
1998 | 2 | 47 | 49 |
1999 | 0 | 36 | 36 |
2000 | 0 | 74 | 74 |
2001 | 1 | 49 | 50 |
2002 | 2 | 79 | 81 |
2003 | 1 | 115 | 116 |
2004 | 1 | 130 | 131 |
2005 | 2 | 120 | 122 |
2006 | 1 | 153 | 154 |
2007 | 2 | 167 | 169 |
2008 | 0 | 194 | 194 |
2009 | 0 | 213 | 213 |
2010 | 0 | 195 | 195 |
2011 | 0 | 205 | 205 |
2012 | 1 | 194 | 195 |
2013 | 0 | 217 | 217 |
2014 | 0 | 179 | 179 |
2015 | 0 | 155 | 155 |
2016 | 0 | 153 | 153 |
2017 | 0 | 165 | 165 |
2018 | 2 | 156 | 158 |
2019 | 0 | 134 | 134 |
2020 | 0 | 155 | 155 |
2021 | 0 | 98 | 98 |
2022 | 0 | 46 | 46 |
2023 | 0 | 38 | 38 |
2024 | 0 | 8 | 8 |
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Below are the most recent publications written about "Mice, Knockout" by people in Profiles.
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TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy. Acta Neuropathol. 2024 Mar 25; 147(1):61.
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Establishment of Murine Pregnancy Requires the Promyelocytic Leukemia Zinc Finger Transcription Factor. Int J Mol Sci. 2024 Mar 19; 25(6).
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A comparative analysis of TonEBP conditional knockout mouse models reveals inter-dependency between compartments of the intervertebral disc. Development. 2024 Mar 15; 151(6).
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Retrograde endocannabinoid signaling at inhibitory synapses in vivo. Science. 2024 Mar; 383(6686):967-970.
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Osteocalcin protects islet identity in low-density lipoprotein receptor knockout mice on high-fat diet. J Endocrinol. 2024 Apr 01; 261(1).
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Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders. J Clin Invest. 2024 Jan 16; 134(2).
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TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex. Nat Commun. 2024 Jan 09; 15(1):406.
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Mouse Gene-Targeting Strategies for Maximum Ease and Versatility. Cold Spring Harb Protoc. 2024 Jan 02; 2024(1):pdb.over107957.
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Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation. Cancer Cell. 2024 01 08; 42(1):85-100.e6.
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Nitric oxide is required for lung alveolarization revealed by deficiency of argininosuccinate lyase. Hum Mol Genet. 2023 Dec 12; 33(1):33-37.