"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Descriptor ID |
D017209
|
MeSH Number(s) |
G04.146.160
|
Concept/Terms |
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
|
Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.
To see the data from this visualization as text,
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Year | Major Topic | Minor Topic | Total |
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1994 | 16 | 8 | 24 |
1995 | 30 | 14 | 44 |
1996 | 38 | 12 | 50 |
1997 | 46 | 23 | 69 |
1998 | 61 | 47 | 108 |
1999 | 48 | 40 | 88 |
2000 | 69 | 62 | 131 |
2001 | 53 | 62 | 115 |
2002 | 71 | 84 | 155 |
2003 | 98 | 108 | 206 |
2004 | 96 | 118 | 214 |
2005 | 102 | 127 | 229 |
2006 | 92 | 135 | 227 |
2007 | 87 | 142 | 229 |
2008 | 57 | 131 | 188 |
2009 | 67 | 136 | 203 |
2010 | 66 | 144 | 210 |
2011 | 75 | 131 | 206 |
2012 | 48 | 134 | 182 |
2013 | 37 | 157 | 194 |
2014 | 44 | 144 | 188 |
2015 | 45 | 119 | 164 |
2016 | 31 | 126 | 157 |
2017 | 32 | 97 | 129 |
2018 | 25 | 70 | 95 |
2019 | 20 | 89 | 109 |
2020 | 15 | 90 | 105 |
2021 | 7 | 78 | 85 |
2022 | 1 | 30 | 31 |
2023 | 2 | 37 | 39 |
2024 | 0 | 4 | 4 |
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Below are the most recent publications written about "Apoptosis" by people in Profiles.
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ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells. Oncotarget. 2024 Mar 14; 15:220-231.
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p90RSK pathway inhibition synergizes with cisplatin in TMEM16A overexpressing head and neck cancer. BMC Cancer. 2024 Feb 19; 24(1):233.
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EphA2- and HDAC-Targeted Combination Therapy in Endometrial Cancer. Int J Mol Sci. 2024 Jan 20; 25(2).
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Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models. J Clin Invest. 2024 Jan 02; 134(1).
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Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-? Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice. Circ Heart Fail. 2023 Dec; 16(12):e010351.
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Angiotensin 1-7 exerts antioxidant effects, suppresses Mammalian Target of Rapamycin (mTOR) signaling, and inhibits apoptosis in renal proximal tubular cells. Peptides. 2024 Feb; 172:171136.
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Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias. Sci Adv. 2023 12; 9(48):eadh1436.
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TP-0184 inhibits FLT3/ACVR1 to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax. Leukemia. 2024 01; 38(1):82-95.
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microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin ?1 recycling on the membrane. Apoptosis. 2024 Feb; 29(1-2):191-209.
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Fucoidan-mediated targeted delivery of dasatinib-loaded nanoparticles amplifies apoptosis and endows cytotoxic potential in triple-negative breast cancer. Colloids Surf B Biointerfaces. 2024 Jan; 233:113631.