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SUYUN HUANG

TitleProfessor
InstitutionMD Anderson
DepartmentNeurosurgery
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang L, Zhang S, Yao J, Lowery FJ, Zhang Q, Huang WC, Li P, Li M, Wang X, Zhang C, Wang H, Ellis K, Cheerathodi M, McCarty JH, Palmieri D, Saunus J, Lakhani S, Huang S, Sahin AA, Aldape KD, Steeg PS, Yu D. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015 Nov 05; 527(7576):100-104. PMID: 26479035; PMCID: PMC4819404.
      Citations: 509     Fields:    Translation:HumansAnimalsCells
    2. Xue J, Zhou A, Tan C, Wu Y, Lee HT, Li W, Xie K, Huang S. Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression. J Biol Chem. 2015 Jul 24; 290(30):18662-70. PMID: 26085085; PMCID: PMC4513123.
      Citations: 14     Fields:    Translation:HumansCells
    3. Gong AH, Wei P, Zhang S, Yao J, Yuan Y, Zhou AD, Lang FF, Heimberger AB, Rao G, Huang S. FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. Cancer Res. 2015 Jun 01; 75(11):2337-48. PMID: 25832656; PMCID: PMC4452436.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    4. Xue J, Chen Y, Wu Y, Wang Z, Zhou A, Zhang S, Lin K, Aldape K, Majumder S, Lu Z, Huang S. Tumour suppressor TRIM33 targets nuclear ?-catenin degradation. Nat Commun. 2015 Feb 02; 6:6156. PMID: 25639486; PMCID: PMC4315364.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    5. Li Z, Jia Z, Gao Y, Xie D, Wei D, Cui J, Mishra L, Huang S, Zhang Y, Xie K. Activation of vitamin D receptor signaling downregulates the expression of nuclear FOXM1 protein and suppresses pancreatic cancer cell stemness. Clin Cancer Res. 2015 Feb 15; 21(4):844-53. PMID: 25501129; PMCID: PMC4334671.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    6. Jiang Y, Wang Y, Wang T, Hawke DH, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu DX, Huang S, Lu Z. PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells. Nat Commun. 2014 Nov 21; 5:5566. PMID: 25412762; PMCID: PMC4259466.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    7. Li L, Li Z, Kong X, Xie D, Jia Z, Jiang W, Cui J, Du Y, Wei D, Huang S, Xie K. Down-regulation of microRNA-494 via loss of SMAD4 increases FOXM1 and ?-catenin signaling in pancreatic ductal adenocarcinoma cells. Gastroenterology. 2014 Aug; 147(2):485-97.e18. PMID: 24859161.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    8. Cui J, Shi M, Xie D, Wei D, Jia Z, Zheng S, Gao Y, Huang S, Xie K. FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. Clin Cancer Res. 2014 May 15; 20(10):2595-606. PMID: 24634381; PMCID: PMC4024335.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    9. Xue J, Lin X, Chiu WT, Chen YH, Yu G, Liu M, Feng XH, Sawaya R, Hung MC, Huang S, Medema RH. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-?-dependent cancer metastasis. J Clin Invest. 2014 Feb; 124(2):564-79. PMID: 24382352; PMCID: PMC3904622.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    10. Zhang S, Huang WC, Zhang L, Zhang C, Lowery FJ, Ding Z, Guo H, Wang H, Huang S, Sahin AA, Aldape KD, Steeg PS, Yu D. SRC family kinases as novel therapeutic targets to treat breast cancer brain metastases. Cancer Res. 2013 Sep 15; 73(18):5764-74. PMID: 23913825; PMCID: PMC3781592.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    11. Kong X, Li L, Li Z, Le X, Huang C, Jia Z, Cui J, Huang S, Wang L, Xie K. Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer. Cancer Res. 2013 Jul 01; 73(13):3987-96. PMID: 23598278; PMCID: PMC3702645.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    12. Dai B, Gong A, Jing Z, Aldape KD, Kang SH, Sawaya R, Huang S. Forkhead box M1 is regulated by heat shock factor 1 and promotes glioma cells survival under heat shock stress. J Biol Chem. 2013 Jan 18; 288(3):1634-42. PMID: 23192351; PMCID: PMC3548473.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    13. Gong A, Huang S. FoxM1 and Wnt/?-catenin signaling in glioma stem cells. Cancer Res. 2012 Nov 15; 72(22):5658-62. PMID: 23139209; PMCID: PMC3500394.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    14. Li D, Wei P, Peng Z, Huang C, Tang H, Jia Z, Cui J, Le X, Huang S, Xie K. The critical role of dysregulated FOXM1-PLAUR signaling in human colon cancer progression and metastasis. Clin Cancer Res. 2013 Jan 01; 19(1):62-72. PMID: 23136192; PMCID: PMC3537853.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    15. Zhang N, Wu X, Yang L, Xiao F, Zhang H, Zhou A, Huang Z, Huang S. FoxM1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51. Clin Cancer Res. 2012 Nov 01; 18(21):5961-71. PMID: 22977194; PMCID: PMC3639123.
      Citations: 56     Fields:    Translation:HumansCells
    16. Li Q, Gao Y, Jia Z, Mishra L, Guo K, Li Z, Le X, Wei D, Huang S, Xie K. Dysregulated Kr?ppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Gastroenterology. 2012 Sep; 143(3):799-810.e2. PMID: 22677193; PMCID: PMC3653768.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    17. Li Y, Zhang S, Huang S. FoxM1: a potential drug target for glioma. Future Oncol. 2012 Mar; 8(3):223-6. PMID: 22409458; PMCID: PMC3627536.
      Citations: 16     Fields:    Translation:Humans
    18. Huang C, Qiu Z, Wang L, Peng Z, Jia Z, Logsdon CD, Le X, Wei D, Huang S, Xie K. A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis. Cancer Res. 2012 Feb 01; 72(3):655-65. PMID: 22194465; PMCID: PMC3271134.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    19. Li Q, Jia Z, Wang L, Kong X, Li Q, Guo K, Tan D, Le X, Wei D, Huang S, Mishra L, Xie K. Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice. Gastroenterology. 2012 Mar; 142(3):531-42. PMID: 22155367; PMCID: PMC3477581.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    20. Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, He X, Huang S, Medema RH. FoxM1 promotes ?-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell. 2011 Oct 18; 20(4):427-42. PMID: 22014570; PMCID: PMC3199318.
      Citations: 282     Fields:    Translation:HumansAnimalsCells
    21. Gao Y, Jia Z, Kong X, Li Q, Chang DZ, Wei D, Le X, Suyun H, Huang S, Wang L, Xie K. Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis. Cancer Res. 2011 Aug 01; 71(15):5182-93. PMID: 21673052; PMCID: PMC3245664.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    22. Chiu WT, Lee HT, Huang FJ, Aldape KD, Yao J, Steeg PS, Chou CY, Lu Z, Xie K, Huang S. Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res. 2011 Jul 15; 71(14):4932-43. PMID: 21622714; PMCID: PMC4170798.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    23. Lockman PR, Mittapalli RK, Taskar KS, Rudraraju V, Gril B, Bohn KA, Adkins CE, Roberts A, Thorsheim HR, Gaasch JA, Huang S, Palmieri D, Steeg PS, Smith QR. Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer. Clin Cancer Res. 2010 Dec 01; 16(23):5664-78. PMID: 20829328; PMCID: PMC2999649.
      Citations: 302     Fields:    Translation:HumansAnimalsCells
    24. Siu TL, Huang S. Cerebral metastases from malignant melanoma: current treatment strategies, advances in novel therapeutics and future directions. Cancers (Basel). 2010 Apr 06; 2(2):364-75. PMID: 24281074; PMCID: PMC3835082.
      Citations: 5     
    25. Dai B, Pieper RO, Li D, Wei P, Liu M, Woo SY, Aldape KD, Sawaya R, Xie K, Huang S. FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes. Cancer Res. 2010 Apr 01; 70(7):2951-61. PMID: 20332230; PMCID: PMC2848915.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    26. Xie TX, Xia Z, Zhang N, Gong W, Huang S. Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma. Oncol Rep. 2010 Mar; 23(3):725-32. PMID: 20127012.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    27. Jia Z, Gao Y, Wang L, Li Q, Zhang J, Le X, Wei D, Yao JC, Chang DZ, Huang S, Xie K. Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. Cancer Res. 2010 Feb 01; 70(3):1111-9. PMID: 20086170; PMCID: PMC2840649.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    28. Li Q, Wei D, Wang L, Wang L, Jia Z, Le X, Gao Y, Huang S, Xie K. Modeling liver metastasis using a tumor cell line derived from an enhanced green fluorescent protein transgenic mouse. Clin Exp Metastasis. 2010; 27(1):11-8. PMID: 19882218.
      Citations: 1     Fields:    Translation:AnimalsCells
    29. Devarajan E, Huang S. STAT3 as a central regulator of tumor metastases. Curr Mol Med. 2009 Jun; 9(5):626-33. PMID: 19601811.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    30. Li Q, Zhang N, Jia Z, Le X, Dai B, Wei D, Huang S, Tan D, Xie K. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. Cancer Res. 2009 Apr 15; 69(8):3501-9. PMID: 19351851; PMCID: PMC4087044.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    31. Huang FJ, Steeg PS, Price JE, Chiu WT, Chou PC, Xie K, Sawaya R, Huang S. Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis. Cancer Res. 2008 Dec 01; 68(23):9634-42. PMID: 19047140; PMCID: PMC7418219.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    32. Zhang Y, Zhang N, Dai B, Liu M, Sawaya R, Xie K, Huang S. FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells. Cancer Res. 2008 Nov 01; 68(21):8733-42. PMID: 18974115; PMCID: PMC2597644.
      Citations: 115     Fields:    Translation:HumansAnimalsCells
    33. Xie TX, Aldape KD, Gong W, Kanzawa T, Suki D, Kondo S, Lang F, Ali-Osman F, Sawaya R, Huang S. Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor. Int J Oncol. 2008 Jul; 33(1):5-15. PMID: 18575745.
      Citations: 7     Fields:    Translation:HumansCells
    34. Dai B, Kang SH, Gong W, Liu M, Aldape KD, Sawaya R, Huang S. Aberrant FoxM1B expression increases matrix metalloproteinase-2 transcription and enhances the invasion of glioma cells. Oncogene. 2007 Sep 13; 26(42):6212-9. PMID: 17404569.
      Citations: 101     Fields:    Translation:HumansCells
    35. Palmieri D, Chambers AF, Felding-Habermann B, Huang S, Steeg PS. The biology of metastasis to a sanctuary site. Clin Cancer Res. 2007 Mar 15; 13(6):1656-62. PMID: 17363518.
      Citations: 62     Fields:    Translation:HumansAnimals
    36. Huang S. Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications. Clin Cancer Res. 2007 Mar 01; 13(5):1362-6. PMID: 17332277.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    37. Liu M, Dai B, Kang SH, Ban K, Huang FJ, Lang FF, Aldape KD, Xie TX, Pelloski CE, Xie K, Sawaya R, Huang S. FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res. 2006 Apr 01; 66(7):3593-602. PMID: 16585184.
      Citations: 171     Fields:    Translation:HumansAnimalsCells
    38. Xie TX, Huang FJ, Aldape KD, Kang SH, Liu M, Gershenwald JE, Xie K, Sawaya R, Huang S. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res. 2006 Mar 15; 66(6):3188-96. PMID: 16540670.
      Citations: 169     Fields:    Translation:HumansAnimals
    39. Xie K, Wei D, Huang S. Transcriptional anti-angiogenesis therapy of human pancreatic cancer. Cytokine Growth Factor Rev. 2006 Jun; 17(3):147-56. PMID: 16516532.
      Citations: 27     Fields:    Translation:HumansCells
    40. Wei D, Kanai M, Huang S, Xie K. Emerging role of KLF4 in human gastrointestinal cancer. Carcinogenesis. 2006 Jan; 27(1):23-31. PMID: 16219632.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    41. Lee HY, Oh SH, Suh YA, Baek JH, Papadimitrakopoulou V, Huang S, Hong WK. Response of non-small cell lung cancer cells to the inhibitors of phosphatidylinositol 3-kinase/Akt- and MAPK kinase 4/c-Jun NH2-terminal kinase pathways: an effective therapeutic strategy for lung cancer. Clin Cancer Res. 2005 Aug 15; 11(16):6065-74. PMID: 16115952.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    42. Gong W, Jiang Y, Wang L, Wei D, Yao J, Huang S, Fang S, Xie K. Expression of autocrine motility factor correlates with the angiogenic phenotype of and poor prognosis for human gastric cancer. Clin Cancer Res. 2005 Aug 15; 11(16):5778-83. PMID: 16115916.
      Citations: 2     Fields:    Translation:Humans
    43. Le X, Wei D, Huang S, Lancaster JR, Xie K. Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8758-63. PMID: 15939886; PMCID: PMC1150810.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    44. Wei D, Gong W, Oh SC, Li Q, Kim WD, Wang L, Le X, Yao J, Wu TT, Huang S, Xie K. Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis. Cancer Res. 2005 Jun 01; 65(11):4809-16. PMID: 15930301.
      Citations: 36     Fields:    Translation:HumansCells
    45. Wei D, Gong W, Kanai M, Schlunk C, Wang L, Yao JC, Wu TT, Huang S, Xie K. Drastic down-regulation of Kr?ppel-like factor 4 expression is critical in human gastric cancer development and progression. Cancer Res. 2005 Apr 01; 65(7):2746-54. PMID: 15805274.
      Citations: 159     Fields:    Translation:HumansCells
    46. Gong W, Wang L, Yao JC, Ajani JA, Wei D, Aldape KD, Xie K, Sawaya R, Huang S. Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin Cancer Res. 2005 Feb 15; 11(4):1386-93. PMID: 15746037.
      Citations: 58     Fields:    Translation:HumansCells
    47. Wang L, Shi GG, Yao JC, Gong W, Wei D, Wu TT, Ajani JA, Huang S, Xie K. Expression of endothelial nitric oxide synthase correlates with the angiogenic phenotype of and predicts poor prognosis in human gastric cancer. Gastric Cancer. 2005; 8(1):18-28. PMID: 15747170.
      Citations: 15     Fields:    Translation:Humans
    48. Wang L, Guan X, Gong W, Yao J, Peng Z, Wei D, Wu TT, Huang S, Xie K. Altered expression of transcription factor Sp1 critically impacts the angiogenic phenotype of human gastric cancer. Clin Exp Metastasis. 2005; 22(3):205-13. PMID: 16158248.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    49. Xie K, Wei D, Shi Q, Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev. 2004 Oct; 15(5):297-324. PMID: 15450248.
      Citations: 44     Fields:    Translation:HumansCells
    50. Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene. 2004 Apr 29; 23(20):3550-60. PMID: 15116091.
      Citations: 246     Fields:    Translation:AnimalsCells
    51. Raza SM, Fuller GN, Rhee CH, Huang S, Hess K, Zhang W, Sawaya R. Identification of necrosis-associated genes in glioblastoma by cDNA microarray analysis. Clin Cancer Res. 2004 Jan 01; 10(1 Pt 1):212-21. PMID: 14734472.
      Citations: 28     Fields:    Translation:Humans
    52. Kim LS, Huang S, Lu W, Lev DC, Price JE. Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice. Clin Exp Metastasis. 2004; 21(2):107-18. PMID: 15168728.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    53. Jiang Y, Wang L, Gong W, Wei D, Le X, Yao J, Ajani J, Abbruzzese JL, Huang S, Xie K. A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer. Clin Exp Metastasis. 2004; 21(8):755-64. PMID: 16035620.
      Citations: 28     Fields:    Translation:HumansAnimals
    54. Wang L, Wei D, Huang S, Peng Z, Le X, Wu TT, Yao J, Ajani J, Xie K. Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer. Clin Cancer Res. 2003 Dec 15; 9(17):6371-80. PMID: 14695137.
      Citations: 150     Fields:    Translation:HumansCells
    55. Wei D, Richardson EL, Zhu K, Wang L, Le X, He Y, Huang S, Xie K. Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthase. Cancer Res. 2003 Jul 15; 63(14):3855-9. PMID: 12873972.
      Citations: 14     Fields:    Translation:AnimalsCells
    56. Karashima T, Sweeney P, Kamat A, Huang S, Kim SJ, Bar-Eli M, McConkey DJ, Dinney CP. Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8. Clin Cancer Res. 2003 Jul; 9(7):2786-97. PMID: 12855659.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    57. Xie K, Huang S. Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency. Free Radic Biol Med. 2003 Apr 15; 34(8):969-86. PMID: 12684082.
      Citations: 24     Fields:    Translation:HumansAnimals
    58. Wang B, Wei D, Crum VE, Richardson EL, Xiong HH, Luo Y, Huang S, Abbruzzese JL, Xie K. A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis. Oncogene. 2003 Mar 27; 22(12):1771-82. PMID: 12660813.
      Citations: 19     Fields:    Translation:Animals
    59. Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene. 2003 Jan 23; 22(3):319-29. PMID: 12545153.
      Citations: 211     Fields:    Translation:HumansAnimalsCells
    60. Xie K, Huang S. Regulation of cancer metastasis by stress pathways. Clin Exp Metastasis. 2003; 20(1):31-43. PMID: 12650605.
      Citations: 28     Fields:    Translation:HumansCells
    61. Mills L, Tellez C, Huang S, Baker C, McCarty M, Green L, Gudas JM, Feng X, Bar-Eli M. Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 2002 Sep 01; 62(17):5106-14. PMID: 12208768.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    62. Huang S, Van Arsdall M, Tedjarati S, McCarty M, Wu W, Langley R, Fidler IJ. Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice. J Natl Cancer Inst. 2002 Aug 07; 94(15):1134-42. PMID: 12165638.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    63. Huang S, Mills L, Mian B, Tellez C, McCarty M, Yang XD, Gudas JM, Bar-Eli M. Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol. 2002 Jul; 161(1):125-34. PMID: 12107097; PMCID: PMC1850702.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    64. Tedjarati S, Baker CH, Apte S, Huang S, Wolf JK, Killion JJ, Fidler IJ. Synergistic therapy of human ovarian carcinoma implanted orthotopically in nude mice by optimal biological dose of pegylated interferon alpha combined with paclitaxel. Clin Cancer Res. 2002 Jul; 8(7):2413-22. PMID: 12114447.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    65. Huang S, Bucana CD, Van Arsdall M, Fidler IJ. Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells. Oncogene. 2002 Apr 11; 21(16):2504-12. PMID: 11971185.
      Citations: 67     Fields:    Translation:AnimalsCells
    66. Huang S, Pettaway CA, Uehara H, Bucana CD, Fidler IJ. Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene. 2001 Jul 12; 20(31):4188-97. PMID: 11464285.
      Citations: 196     Fields:    Translation:HumansAnimalsCells
    67. Gershenwald JE, Sumner W, Calderone T, Wang Z, Huang S, Bar-Eli M. Dominant-negative transcription factor AP-2 augments SB-2 melanoma tumor growth in vivo. Oncogene. 2001 Jun 07; 20(26):3363-75. PMID: 11423987.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    68. Huang S, Robinson JB, Deguzman A, Bucana CD, Fidler IJ. Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res. 2000 Oct 01; 60(19):5334-9. PMID: 11034066.
      Citations: 111     Fields:    Translation:HumansAnimalsCells
    69. Huang S, DeGuzman A, Bucana CD, Fidler IJ. Nuclear factor-kappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice. Clin Cancer Res. 2000 Jun; 6(6):2573-81. PMID: 10873114.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    70. Jean D, Tellez C, Huang S, Davis DW, Bruns CJ, McConkey DJ, Hinrichs SH, Bar-Eli M. Inhibition of tumor growth and metastasis of human melanoma by intracellular anti-ATF-1 single chain Fv fragment. Oncogene. 2000 May 18; 19(22):2721-30. PMID: 10851072.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    71. Huang S, DeGuzman A, Bucana CD, Fidler IJ. Level of interleukin-8 expression by metastatic human melanoma cells directly correlates with constitutive NF-kappaB activity. Cytokines Cell Mol Ther. 2000 Mar; 6(1):9-17. PMID: 10976534.
      Citations: 19     Fields:    Translation:HumansCells
    72. Shi Q, Le X, Abbruzzese JL, Wang B, Mujaida N, Matsushima K, Huang S, Xiong Q, Xie K. Cooperation between transcription factor AP-1 and NF-kappaB in the induction of interleukin-8 in human pancreatic adenocarcinoma cells by hypoxia. J Interferon Cytokine Res. 1999 Dec; 19(12):1363-71. PMID: 10638705.
      Citations: 29     Fields:    Translation:HumansCells
    73. Shi Q, Abbruzzese JL, Huang S, Fidler IJ, Xiong Q, Xie K. Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. Clin Cancer Res. 1999 Nov; 5(11):3711-21. PMID: 10589791.
      Citations: 92     Fields:    Translation:HumansAnimals
    74. Huang S, Ullrich SE, Bar-Eli M. Regulation of tumor growth and metastasis by interleukin-10: the melanoma experience. J Interferon Cytokine Res. 1999 Jul; 19(7):697-703. PMID: 10454339.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    75. Shi Q, Huang S, Jiang W, Kutach LS, Ananthaswamy HN, Xie K. Direct correlation between nitric oxide synthase II inducibility and metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53. Cancer Res. 1999 May 01; 59(9):2072-5. PMID: 10232590.
      Citations: 6     Fields:    Translation:AnimalsCells
    76. Huang S, Jean D, Luca M, Tainsky MA, Bar-Eli M. Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis. EMBO J. 1998 Aug 03; 17(15):4358-69. PMID: 9687504; PMCID: PMC1170769.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    77. Rodrigues-Lima F, Huang S, Xie K, Guillaume N, Bar-Eli M, Frade R. Procathepsin-L, a proteinase that cleaves human C3 (the third component of complement), confers high tumorigenic and metastatic properties to human melanoma cells. Cancer Res. 1998 Jul 01; 58(13):2733-6. PMID: 9661883.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    78. Jean D, Gershenwald JE, Huang S, Luca M, Hudson MJ, Tainsky MA, Bar-Eli M. Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells. J Biol Chem. 1998 Jun 26; 273(26):16501-8. PMID: 9632718.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    79. Xie K, Bielenberg D, Huang S, Xu L, Salas T, Juang SH, Dong Z, Fidler IJ. Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-beta gene: possible role of nitric oxide. Clin Cancer Res. 1997 Dec; 3(12 Pt 1):2283-94. PMID: 9815626.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    80. Luca M, Huang S, Gershenwald JE, Singh RK, Reich R, Bar-Eli M. Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis. Am J Pathol. 1997 Oct; 151(4):1105-13. PMID: 9327744; PMCID: PMC1858026.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    81. Xie K, Wang Y, Huang S, Xu L, Bielenberg D, Salas T, McConkey DJ, Jiang W, Fidler IJ. Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2. Oncogene. 1997 Aug 14; 15(7):771-9. PMID: 9266963.
      Citations: 15     Fields:    Translation:AnimalsCells
    82. Xie S, Luca M, Huang S, Gutman M, Reich R, Johnson JP, Bar-Eli M. Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis. Cancer Res. 1997 Jun 01; 57(11):2295-303. PMID: 9187135.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    83. Xie K, Huang S, Dong Z, Juang SH, Wang Y, Fidler IJ. Destruction of bystander cells by tumor cells transfected with inducible nitric oxide (NO) synthase gene. J Natl Cancer Inst. 1997 Mar 19; 89(6):421-7. PMID: 9091643.
      Citations: 9     Fields:    Translation:AnimalsCells
    84. Huang S, Luca M, Gutman M, McConkey DJ, Langley KE, Lyman SD, Bar-Eli M. Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential. Oncogene. 1996 Dec 05; 13(11):2339-47. PMID: 8957075.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    85. Huang S, Xie K, Bucana CD, Ullrich SE, Bar-Eli M. Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis. Clin Cancer Res. 1996 Dec; 2(12):1969-79. PMID: 9816156.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    86. Xie K, Huang S, Wang Y, Beltran PJ, Juang SH, Dong Z, Reed JC, McDonnell TJ, McConkey DJ, Fidler IJ. Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis. Cancer Immunol Immunother. 1996 Oct; 43(2):109-15. PMID: 8954145.
      Citations: 2     Fields:    Translation:AnimalsCells
    87. Bar-Eli M, Huang S, Xie K, Rodrigues-Lima F, Hermann J, Frade R, Jean D. A cysteine proteinase, which cleaves human C3, the third component of complement, is involved in tumorigenicity and metastasis of human melanoma. Cancer Res. 1996 Jan 15; 56(2):254-8. PMID: 8542576.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    88. Luca M, Xie S, Gutman M, Huang S, Bar-Eli M. Abnormalities in the CDKN2 (p16INK4/MTS-1) gene in human melanoma cells: relevance to tumor growth and metastasis. Oncogene. 1995 Oct 05; 11(7):1399-402. PMID: 7478563.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    89. Xie K, Huang S, Dong Z, Gutman M, Fidler IJ. Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362. Cancer Res. 1995 Jul 15; 55(14):3123-31. PMID: 7541713.
      Citations: 19     Fields:    Translation:AnimalsCells
    90. Huang S, Xie K, Singh RK, Gutman M, Bar-Eli M. Suppression of tumor growth and metastasis of murine renal adenocarcinoma by syngeneic fibroblasts genetically engineered to secrete the JE/MCP-1 cytokine. J Interferon Cytokine Res. 1995 Jul; 15(7):655-65. PMID: 7553238.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    91. Xie K, Huang S, Dong Z, Juang SH, Gutman M, Xie QW, Nathan C, Fidler IJ. Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J Exp Med. 1995 Apr 01; 181(4):1333-43. PMID: 7535333; PMCID: PMC2191958.
      Citations: 54     Fields:    Translation:AnimalsCells
    92. Huang S, Singh RK, Xie K, Gutman M, Berry KK, Bucana CD, Fidler IJ, Bar-Eli M. Expression of the JE/MCP-1 gene suppresses metastatic potential in murine colon carcinoma cells. Cancer Immunol Immunother. 1994 Oct; 39(4):231-8. PMID: 7954525.
      Citations: 25     Fields:    Translation:AnimalsCells
    93. miR-182-5p induced by STAT3 activation promotes glioma tumorigenesis. Cancer Research. 76:4293-4304.
    94. Cytokine-induced apoptosis in transformed murine fibroblasts involves synthesis of endogenous nitric oxide. International Journal of Oncology. 3:1043-1048.
    95. Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells. Oncotarget. 6:10016-10029.
    96. FOXM1 promotes reprogramming of glucose metabolism in epithelial ovarian cancer cells via activation of GLUT1 and HK2 transcription. Oncotarget. 7:47985-47997.
    97. KLF4-mediated suppression of CD44 signaling negatively impacts pancreatic cancer stemness and metastasis. Cancer Research. 76:2419-2431.
    98. Merlin/NF2 suppresses pancreatic tumor growth and metastasis by attenuating the FOXM1-mediated Wnt/β-catenin signaling. Cancer Research. 75:4778-4789.
    99. Cerebral metastases from malignant melanoma. Cancers. 2:364-375.
    100. Glioblastoma multiforme formation and EMT. Current Pharmaceutical Design. 21:1268-1271.
    101. Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22. Nature Cell Biology.
    102. Crosstalk of the Wnt/β-catenin pathway with other pathways in cancer cells. Genes and Diseases. 3:41-47.
    103. HGF/Met and FOXM1 form a positive feedback loop and render pancreatic cancer cells resistance to Met inhibition and aggressive phenotypes. Oncogene.
    104. Metformin potentiates rapamycin and cisplatin in gastric cancer in mice. Oncotarget. 6:12748-12762.
    105. FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway. Oncotarget. 6:11281-11294.
    106. KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell. 29:324-338.
    107. 10 Immunohistochemical detection of activated Stat3 protein in pancreatic cancer. 363-369.
    108. Mir-21-Sox2 axis delineates glioblastoma subtypes with prognostic impact. Journal of Neuroscience. 35:15097-15112.
    109. Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation. EMBO Journal. 35:668-684.
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