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XIANGWEI WU

TitleAssociate Professor
InstitutionMD Anderson
DepartmentClinical Cancer Prevention
Address6767 Bertner St
Houston TX 77030-2603
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    Collapse Research 
    Collapse research activities and funding
    75N91019D00     (DATTA, KIRAN)Jun 1, 2023 - Sep 21, 2028
    NIH
    PHASE 1 AND PHASE 2 CLINICAL TRIALS FOR NEXT-GENERATION CORONAVIRUS VACCINES
    Role: Co-Principal Investigator
    R01CA214954     (WU, XIANGWEI)Jun 12, 2018 - May 31, 2024
    NIH
    Activating p53 for colorectal cancer prevention
    Role: Principal Investigator
    R01AI063063     (WU, XIANGWEI)Dec 15, 2004 - Nov 30, 2010
    NIH
    Regulation of Cellular Response to TNF
    Role: Principal Investigator
    R01CA073678     (WU, XIANGWEI)Apr 1, 1997 - Mar 31, 2008
    NIH
    Mechanisms of P53 Mediated Apoptosis and Carcinogenesis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yue F, Ku AT, Stevens PD, Michalski MN, Jiang W, Tu J, Shi Z, Dou Y, Wang Y, Feng XH, Hostetter G, Wu X, Huang S, Shroyer NF, Zhang B, Williams BO, Liu Q, Lin X, Li Y, Yue F, Ku AT, Stevens PD, Michalski MN, Jiang W, Tu J, Shi Z, Dou Y, Wang Y, Feng XH, Hostetter G, Wu X, Huang S, Shroyer NF, Zhang B, Williams BO, Liu Q, Lin X, Li Y. Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer. bioRxiv. 2024 Jan 11. PMID: 38260423; PMCID: PMC10802575.
      Citations:    
    2. Wang H, Wu X. Detection and Enumeration of Circulating Tumor Cells with Invasive Phenotype. Adv Exp Med Biol. 2017; 994:133-141. PMID: 28560672.
      Citations:    Fields:    Translation:HumansCells
    3. Liu X, Wu X. Utilizing Matrigel Transwell Invasion Assay to Detect and Enumerate Circulating Tumor Cells. Methods Mol Biol. 2017; 1634:277-282. PMID: 28819859.
      Citations: 5     Fields:    Translation:HumansCells
    4. Davis JS, Gupta V, Gagea M, Wu X. An Advanced Histologic Method for Evaluation of Intestinal Adenomas in Mice Using Digital Slides. PLoS One. 2016; 11(3):e0151463. PMID: 26974326; PMCID: PMC4790911.
      Citations:    Fields:    Translation:Animals
    5. Wang H, Hara Y, Liu X, Reuben JM, Xie Y, Xu H, Bu G, Pei Y, Gupta V, Wu X. Detection and enumeration of circulating tumor cells based on their invasive property. Oncotarget. 2015 Sep 29; 6(29):27304-11. PMID: 26247814; PMCID: PMC4694991.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    6. Wang H, Yang T, Wu X. 5-Fluorouracil preferentially sensitizes mutant KRAS non-small cell lung carcinoma cells to TRAIL-induced apoptosis. Mol Oncol. 2015 Nov; 9(9):1815-24. PMID: 26130327; PMCID: PMC5528717.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    7. Shen J, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G. ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors. Cancer Discov. 2015 Jul; 5(7):752-67. PMID: 26069190; PMCID: PMC4497871.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    8. Lukianova-Hleb EY, Ren X, Sawant RR, Wu X, Torchilin VP, Lapotko DO. On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles. Nat Med. 2014 Jul; 20(7):778-784. PMID: 24880615; PMCID: PMC4271542.
      Citations: 36     Fields:    Translation:HumansAnimals
    9. Wang H, Davis JS, Wu X. Immunoglobulin Fc domain fusion to TRAIL significantly prolongs its plasma half-life and enhances its antitumor activity. Mol Cancer Ther. 2014 Mar; 13(3):643-50. PMID: 24431076.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    10. Lukianova-Hleb EY, Volkov AN, Wu X, Lapotko DO. Transient enhancement and spectral narrowing of the photothermal effect of plasmonic nanoparticles under pulsed excitation. Adv Mater. 2013 Feb 06; 25(5):772-6. PMID: 23161793; PMCID: PMC3772718.
      Citations: 7     Fields:    
    11. Lukianova-Hleb EY, Ren X, Townley D, Wu X, Kupferman ME, Lapotko DO. Plasmonic nanobubbles rapidly detect and destroy drug-resistant tumors. Theranostics. 2012; 2(10):976-87. PMID: 23139725; PMCID: PMC3493199.
      Citations: 9     Fields:    
    12. Davis JS, Wu X. Current state and future challenges of chemoprevention. Discov Med. 2012 May; 13(72):385-90. PMID: 22642920.
      Citations: 2     Fields:    Translation:Humans
    13. Lukianova-Hleb EY, Ren X, Constantinou PE, Danysh BP, Shenefelt DL, Carson DD, Farach-Carson MC, Kulchitsky VA, Wu X, Wagner DS, Lapotko DO. Improved cellular specificity of plasmonic nanobubbles versus nanoparticles in heterogeneous cell systems. PLoS One. 2012; 7(4):e34537. PMID: 22509318; PMCID: PMC3317980.
      Citations: 13     Fields:    Translation:HumansCells
    14. Lukianova-Hleb EY, Ren X, Zasadzinski JA, Wu X, Lapotko DO. Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells. Adv Mater. 2012 Jul 24; 24(28):3831-7. PMID: 22407874; PMCID: PMC3407535.
      Citations: 30     Fields:    Translation:HumansCells
    15. Lukianova-Hleb EY, Belyanin A, Kashinath S, Wu X, Lapotko DO. Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells. Biomaterials. 2012 Feb; 33(6):1821-6. PMID: 22137124; PMCID: PMC3340418.
      Citations: 24     Fields:    Translation:HumansCells
    16. Wu X, Lippman SM. An intermittent approach for cancer chemoprevention. Nat Rev Cancer. 2011 11 10; 11(12):879-85. PMID: 22071977.
      Citations: 21     Fields:    Translation:HumansAnimals
    17. Wu X, Patterson S, Hawk E. Chemoprevention--history and general principles. Best Pract Res Clin Gastroenterol. 2011 Aug; 25(4-5):445-59. PMID: 22122762.
      Citations: 14     Fields:    Translation:HumansAnimals
    18. Huang S, Ren X, Wang L, Zhang L, Wu X. Lung-cancer chemoprevention by induction of synthetic lethality in mutant KRAS premalignant cells in vitro and in vivo. Cancer Prev Res (Phila). 2011 May; 4(5):666-73. PMID: 21543344.
      Citations: 16     Fields:    Translation:HumansAnimals
    19. Zhang L, Ren X, Alt E, Bai X, Huang S, Xu Z, Lynch PM, Moyer MP, Wen XF, Wu X. Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature. 2010 Apr 15; 464(7291):1058-61. PMID: 20348907; PMCID: PMC3425353.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    20. Ren X, Xu Z, Myers JN, Wu X. Bypass NFkappaB-mediated survival pathways by TRAIL and Smac. Cancer Biol Ther. 2007 Jul; 6(7):1031-5. PMID: 17611406.
      Citations: 5     Fields:    Translation:HumansCells
    21. Yang L, Deng YB, Wu XW. [Bcl-xl blocks tumor necrosis factor alpha-induced caspase 8 activation and apoptosis]. Zhonghua Gan Zang Bing Za Zhi. 2005 Apr; 13(4):286-9. PMID: 15850519.
      Citations:    Fields:    Translation:HumansCells
    22. Deng Y, Ren X, Yang L, Lin Y, Wu X. A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell. 2003 Oct 03; 115(1):61-70. PMID: 14532003.
      Citations: 211     Fields:    Translation:HumansAnimalsCells
    23. Johnson MD, Wu X, Aithmitti N, Morrison RS. Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death. J Biol Chem. 2002 Jun 21; 277(25):23000-7. PMID: 11943780.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    24. Wu X, Deng Y. Bax and BH3-domain-only proteins in p53-mediated apoptosis. Front Biosci. 2002 Jan 01; 7:d151-6. PMID: 11779719.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    25. Deng Y, Lin Y, Wu X. TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev. 2002 Jan 01; 16(1):33-45. PMID: 11782443; PMCID: PMC155309.
      Citations: 110     Fields:    Translation:HumansCells
    26. Xia X, Qian S, Soriano S, Wu Y, Fletcher AM, Wang XJ, Koo EH, Wu X, Zheng H. Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10863-8. PMID: 11517342; PMCID: PMC58565.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    27. Buschmann T, Lin Y, Aithmitti N, Fuchs SY, Lu H, Resnick-Silverman L, Manfredi JJ, Ronai Z, Wu X. Stabilization and activation of p53 by the coactivator protein TAFII31. J Biol Chem. 2001 Apr 27; 276(17):13852-7. PMID: 11278372.
      Citations: 24     Fields:    Translation:AnimalsCells
    28. Deng Y, Wu X. Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12050-5. PMID: 11050235; PMCID: PMC17292.
      Citations: 68     Fields:    Translation:Cells
    29. Relaix F, Wei Xj, Li W, Pan J, Lin Y, Bowtell DD, Sassoon DA, Wu X. Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. Proc Natl Acad Sci U S A. 2000 Feb 29; 97(5):2105-10. PMID: 10681424; PMCID: PMC15761.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    30. Fuchs SY, Adler V, Buschmann T, Wu X, Ronai Z. Mdm2 association with p53 targets its ubiquitination. Oncogene. 1998 Nov 12; 17(19):2543-7. PMID: 9824166.
      Citations: 83     Fields:    Translation:AnimalsCells
    31. Fuchs SY, Adler V, Buschmann T, Yin Z, Wu X, Jones SN, Ronai Z. JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev. 1998 Sep 01; 12(17):2658-63. PMID: 9732264; PMCID: PMC317120.
      Citations: 88     Fields:    Translation:AnimalsCells
    32. Relaix F, Wei XJ, Wu X, Sassoon DA. Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. Nat Genet. 1998 Mar; 18(3):287-91. PMID: 9500555.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    33. Chen J, Wu X, Lin J, Levine AJ. mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol. 1996 May; 16(5):2445-52. PMID: 8628312; PMCID: PMC231233.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    34. Lin J, Reichner C, Wu X, Levine AJ. Analysis of wild-type and mutant p21WAF-1 gene activities. Mol Cell Biol. 1996 Apr; 16(4):1786-93. PMID: 8657154; PMCID: PMC231165.
      Citations: 37     Fields:    Translation:HumansCells
    35. Wu X, Levine AJ. p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3602-6. PMID: 8170954; PMCID: PMC43628.
      Citations: 210     Fields:    Translation:Cells
    36. Wu X, Wakamiya M, Vaishnav S, Geske R, Montgomery C, Jones P, Bradley A, Caskey CT. Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):742-6. PMID: 8290593; PMCID: PMC43025.
      Citations: 98     Fields:    Translation:HumansAnimals
    37. Lin J, Wu X, Chen J, Chang A, Levine AJ. Functions of the p53 protein in growth regulation and tumor suppression. Cold Spring Harb Symp Quant Biol. 1994; 59:215-23. PMID: 7587073.
      Citations: 6     Fields:    Translation:HumansCells
    38. Wu X, Bayle JH, Olson D, Levine AJ. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 1993 Jul; 7(7A):1126-32. PMID: 8319905.
      Citations: 625     Fields:    Translation:AnimalsCells
    39. Wu XW, Muzny DM, Lee CC, Caskey CT. Two independent mutational events in the loss of urate oxidase during hominoid evolution. J Mol Evol. 1992 Jan; 34(1):78-84. PMID: 1556746.
      Citations: 148     Fields:    Translation:HumansAnimalsCells
    40. Wu XW, Lee CC, Muzny DM, Caskey CT. Urate oxidase: primary structure and evolutionary implications. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9412-6. PMID: 2594778; PMCID: PMC298506.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    41. Lee CC, Wu XW, Caskey CT. Cloning the full-length cDNA for the porcine urate oxidase by the MOPAC generated probe. Adv Exp Med Biol. 1989; 253A:499-505. PMID: 2624230.
      Citations: 1     Fields:    Translation:Animals
    42. Lee CC, Wu XW, Gibbs RA, Cook RG, Muzny DM, Caskey CT. Generation of cDNA probes directed by amino acid sequence: cloning of urate oxidase. Science. 1988 Mar 11; 239(4845):1288-91. PMID: 3344434.
      Citations: 82     Fields:    Translation:AnimalsCells
    43. Detection and enumeration of circulating tumor cells based on their invasive property. Oncotarget. 6:27304-27311.
    44. Plasmonic nanobubble theranostics for intra-operative and preventive treatment of head and neck squamous cell carcinoma.
    45. Low-dose 5-fluorouracil sensitizes HepG2 cells to TRAIL through TRAIL receptor DR5 and survivin-dependent mechanisms. Journal of Chemotherapy. 1-10.
    46. An advanced histologic method for evaluation of intestinal adenomas in mice using digital slides. PLoS One. 11.
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