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SEON HEE CHANG

TitleAssistant Professor
InstitutionMD Anderson
DepartmentImmunology
Address7455 Fannin St
Houston TX 77054-1901
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yuan B, Clowers MJ, Velasco WV, Peng S, Peng Q, Shi Y, Ramos-Castaneda M, Zarghooni M, Yang S, Babcock RL, Chang SH, Heymach JV, Zhang J, Ostrin EJ, Watowich SS, Kadara H, Moghaddam SJ. Targeting IL-1? as an immunopreventive and therapeutic modality for K-ras-mutant lung cancer. JCI Insight. 2022 06 08; 7(11). PMID: 35471938; PMCID: PMC9220853.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C. Author Correction: Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol. 2020 Nov; 21(11):1467. PMID: 32884131.
      Citations:    Fields:    
    3. Kim BS, Clinton J, Wang Q, Chang SH. Targeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancer. Oncoimmunology. 2020; 9(1):1682380. PMID: 32002289; PMCID: PMC6959450.
      Citations: 7     Fields:    Translation:AnimalsCells
    4. Avritscher R, Jo N, Polak U, Cortes AC, Nishiofuku H, Odisio BC, Takaki H, Tam AL, Melancon MP, Yevich S, Qayyum A, Kaseb A, Kichikawa K, Gupta S, Goldberg SN, Chang SH. Hepatic Arterial Bland Embolization Increases Th17 Cell Infiltration in a Syngeneic Rat Model of Hepatocellular Carcinoma. Cardiovasc Intervent Radiol. 2020 Feb; 43(2):311-321. PMID: 31591689.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    5. Lee Y, Clinton J, Yao C, Chang SH. Interleukin-17D Promotes Pathogenicity During Infection by Suppressing CD8 T Cell Activity. Front Immunol. 2019; 10:1172. PMID: 31244826; PMCID: PMC6562898.
      Citations: 9     Fields:    Translation:AnimalsCells
    6. Chang SH. T helper 17 (Th17) cells and interleukin-17 (IL-17) in cancer. Arch Pharm Res. 2019 Jul; 42(7):549-559. PMID: 30941641.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    7. Khosravi N, Caetano MS, Cumpian AM, Unver N, Daliri S, Hernandez BJ, Gutierrez BA, Evans SE, Hanash S, Alekseev AM, Yang Y, Chang SH, Nurieva R, Kadara H, Chen J, Ostrin EJ, Moghaddam SJ, De la Garza Ramos C, Noble O. IL22 Promotes Kras-Mutant Lung Cancer by Induction of a Protumor Immune Response and Protection of Stemness Properties. Cancer Immunol Res. 2018 07; 6(7):788-797. PMID: 29764837; PMCID: PMC6030457.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    8. Kim BS, Lu H, Ichiyama K, Chen X, Zhang YB, Mistry NA, Tanaka K, Lee YH, Nurieva R, Zhang L, Yang X, Chung Y, Jin W, Chang SH, Dong C. Generation of ROR?t+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity. Cell Rep. 2017 Oct 03; 21(1):195-207. PMID: 28978473; PMCID: PMC5716359.
      Citations: 43     Fields:    Translation:AnimalsCells
    9. Caetano MS, Zhang H, Cumpian AM, Gong L, Unver N, Ostrin EJ, Daliri S, Chang SH, Ochoa CE, Hanash S, Behrens C, Wistuba II, Sternberg C, Kadara H, Ferreira CG, Watowich SS, Moghaddam SJ. IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer. Cancer Res. 2016 06 01; 76(11):3189-99. PMID: 27197187; PMCID: PMC4891282.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    10. Chang SH. Tumorigenic Th17 cells in oncogenic Kras-driven and inflammation-accelerated lung cancer. Oncoimmunology. 2015 Jan; 4(1):e955704. PMID: 25949859; PMCID: PMC4368138.
      Citations: 6     Fields:    
    11. Chang SH, Mirabolfathinejad SG, Katta H, Cumpian AM, Gong L, Caetano MS, Moghaddam SJ, Dong C. T helper 17 cells play a critical pathogenic role in lung cancer. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):5664-9. PMID: 24706787; PMCID: PMC3992670.
      Citations: 135     Fields:    Translation:AnimalsCells
    12. Chung Y, Yamazaki T, Kim BS, Zhang Y, Reynolds JM, Martinez GJ, Chang SH, Lim H, Birkenbach M, Dong C. Epstein Barr virus-induced 3 (EBI3) together with IL-12 negatively regulates T helper 17-mediated immunity to Listeria monocytogenes infection. PLoS Pathog. 2013 Sep; 9(9):e1003628. PMID: 24068935; PMCID: PMC3777861.
      Citations: 10     Fields:    Translation:AnimalsCells
    13. Yang XO, Zhang H, Kim BS, Niu X, Peng J, Chen Y, Kerketta R, Lee YH, Chang SH, Corry DB, Wang D, Watowich SS, Dong C. The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol. 2013 Jul; 14(7):732-40. PMID: 23727894; PMCID: PMC4084713.
      Citations: 60     Fields:    Translation:AnimalsCells
    14. Zhong B, Liu X, Wang X, Chang SH, Liu X, Wang A, Reynolds JM, Dong C. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. Nat Immunol. 2012 Nov; 13(11):1110-7. PMID: 23042150; PMCID: PMC3477275.
      Citations: 73     Fields:    Translation:AnimalsCells
    15. Reynolds JM, Martinez GJ, Nallaparaju KC, Chang SH, Wang YH, Dong C. Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C. J Immunol. 2012 Nov 01; 189(9):4226-30. PMID: 23024280; PMCID: PMC3478486.
      Citations: 43     Fields:    Translation:AnimalsCells
    16. Liu X, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med. 2012 Sep 24; 209(10):1841-52, S1-24. PMID: 22987803; PMCID: PMC3457730.
      Citations: 122     Fields:    Translation:AnimalsCells
    17. Shan M, Yuan X, Song LZ, Roberts L, Zarinkamar N, Seryshev A, Zhang Y, Hilsenbeck S, Chang SH, Dong C, Corry DB, Kheradmand F. Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. Sci Transl Med. 2012 Jan 18; 4(117):117ra9. PMID: 22261033; PMCID: PMC3956594.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    18. Wang X, Zhang Y, Yang XO, Nurieva RI, Chang SH, Ojeda SS, Kang HS, Schluns KS, Gui J, Jetten AM, Dong C. Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2. Immunity. 2012 Jan 27; 36(1):23-31. PMID: 22244845; PMCID: PMC3270375.
      Citations: 61     Fields:    Translation:AnimalsCells
    19. Chang SH, Reynolds JM, Pappu BP, Chen G, Martinez GJ, Dong C. Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E. Immunity. 2011 Oct 28; 35(4):611-21. PMID: 21982598; PMCID: PMC5800502.
      Citations: 96     Fields:    Translation:AnimalsCells
    20. Hong JS, Greenlee KJ, Pitchumani R, Lee SH, Song LZ, Shan M, Chang SH, Park PW, Dong C, Werb Z, Bidani A, Corry DB, Kheradmand F. Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae. J Immunol. 2011 Jun 01; 186(11):6427-36. PMID: 21508260; PMCID: PMC3546495.
      Citations: 14     Fields:    Translation:AnimalsCells
    21. Chang SH, Dong C. Signaling of interleukin-17 family cytokines in immunity and inflammation. Cell Signal. 2011 Jul; 23(7):1069-75. PMID: 21130872; PMCID: PMC3078175.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    22. Chang SH, Chung Y, Dong C. Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression. J Biol Chem. 2010 Dec 10; 285(50):38751-5. PMID: 20974859; PMCID: PMC2998156.
      Citations: 80     Fields:    Translation:AnimalsCells
    23. Yu HS, Angkasekwinai P, Chang SH, Chung Y, Dong C. Protease allergens induce the expression of IL-25 via Erk and p38 MAPK pathway. J Korean Med Sci. 2010 Jun; 25(6):829-34. PMID: 20514301; PMCID: PMC2877219.
      Citations: 31     Fields:    Translation:AnimalsCells
    24. Angkasekwinai P, Chang SH, Thapa M, Watarai H, Dong C. Regulation of IL-9 expression by IL-25 signaling. Nat Immunol. 2010 Mar; 11(3):250-6. PMID: 20154671; PMCID: PMC2827302.
      Citations: 95     Fields:    Translation:AnimalsCells
    25. Peng J, Yang XO, Chang SH, Yang J, Dong C. IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation. Cell Res. 2010 Jan; 20(1):62-71. PMID: 19935773; PMCID: PMC2801763.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    26. Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol. 2009 Dec; 10(12):1260-6. PMID: 19881507; PMCID: PMC2784129.
      Citations: 47     Fields:    Translation:AnimalsCells
    27. Zhang Y, Reynolds JM, Chang SH, Martin-Orozco N, Chung Y, Nurieva RI, Dong C. MKP-1 is necessary for T cell activation and function. J Biol Chem. 2009 Nov 06; 284(45):30815-24. PMID: 19748894; PMCID: PMC2781480.
      Citations: 37     Fields:    Translation:AnimalsCells
    28. Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS, Ma L, Watowich SS, Jetten AM, Tian Q, Dong C. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity. 2009 Apr 17; 30(4):576-87. PMID: 19362022; PMCID: PMC2705871.
      Citations: 573     Fields:    Translation:AnimalsCells
    29. Chang SH, Dong C. IL-17F: regulation, signaling and function in inflammation. Cytokine. 2009 Apr; 46(1):7-11. PMID: 19233684; PMCID: PMC2663007.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    30. Martin-Orozco N, Chung Y, Chang SH, Wang YH, Dong C. Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol. 2009 Jan; 39(1):216-24. PMID: 19130584; PMCID: PMC2755057.
      Citations: 168     Fields:    Translation:AnimalsCells
    31. Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity. 2008 Jul 18; 29(1):44-56. PMID: 18585065; PMCID: PMC2630532.
      Citations: 549     Fields:    Translation:AnimalsCells
    32. Yang XO, Chang SH, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns KS, Broaddus RR, Zhu Z, Dong C. Regulation of inflammatory responses by IL-17F. J Exp Med. 2008 May 12; 205(5):1063-75. PMID: 18411338; PMCID: PMC2373839.
      Citations: 339     Fields:    Translation:AnimalsCells
    33. Angkasekwinai P, Park H, Wang YH, Wang YH, Chang SH, Corry DB, Liu YJ, Zhu Z, Dong C. Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med. 2007 Jul 09; 204(7):1509-17. PMID: 17562814; PMCID: PMC2118650.
      Citations: 217     Fields:    Translation:HumansAnimalsCells
    34. Chang SH, Dong C. A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res. 2007 May; 17(5):435-40. PMID: 17452998.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    35. Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem. 2007 Mar 30; 282(13):9358-9363. PMID: 17277312.
      Citations: 634     Fields:    Translation:AnimalsCells
    36. Chung Y, Yang X, Chang SH, Ma L, Tian Q, Dong C. Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res. 2006 Nov; 16(11):902-7. PMID: 17088898.
      Citations: 97     Fields:    Translation:AnimalsCells
    37. Chang SH, Park H, Dong C. Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor. J Biol Chem. 2006 Nov 24; 281(47):35603-7. PMID: 17035243.
      Citations: 158     Fields:    Translation:HumansAnimalsCells
    38. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005 Nov; 6(11):1133-41. PMID: 16200068; PMCID: PMC1618871.
      Citations: 1649     Fields:    Translation:AnimalsCells
    39. Gallagher PG, Chang SH, Rettig MP, Neely JE, Hillery CA, Smith BD, Low PS. Altered erythrocyte endothelial adherence and membrane phospholipid asymmetry in hereditary hydrocytosis. Blood. 2003 Jun 01; 101(11):4625-7. PMID: 12560240.
      Citations: 37     Fields:    Translation:HumansCells
    40. Chang SH, Low PS. Identification of a critical ankyrin-binding loop on the cytoplasmic domain of erythrocyte membrane band 3 by crystal structure analysis and site-directed mutagenesis. J Biol Chem. 2003 Feb 28; 278(9):6879-84. PMID: 12482869.
      Citations: 37     Fields:    Translation:HumansCells
    41. Khanna R, Chang SH, Andrabi S, Azam M, Kim A, Rivera A, Brugnara C, Low PS, Liu SC, Chishti AH. Headpiece domain of dematin is required for the stability of the erythrocyte membrane. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6637-42. PMID: 12011427; PMCID: PMC124455.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    42. Chang SH, Low PS. Regulation of the glycophorin C-protein 4.1 membrane-to-skeleton bridge and evaluation of its contribution to erythrocyte membrane stability. J Biol Chem. 2001 Jun 22; 276(25):22223-30. PMID: 11294862.
      Citations: 22     Fields:    Translation:Cells
    43. Tumorigenic Th17 cells in oncogenic Kras-driven and inflammation-accelerated lung cancer. OncoImmunology. 4:955704.
    44. IL6 blockade reprograms the lung tumor microenvironment to limit the development and progression of K-ras-mutant lung cancer. Cancer Research. 76:3189-3199.
    45. Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment. OncoImmunology.
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