Header Logo

HIROHITO YAMAGUCHI

TitleAssociate Professor
InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address1515 Holcombe Blvd
Houston TX 77030-4009
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chu YY, Yam C, Yamaguchi H, Hung MC. Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors. J Biomed Sci. 2022 Oct 25; 29(1):86. PMID: 36284291; PMCID: PMC9594904.
      Citations: 1     Fields:    Translation:Humans
    2. Chu YY, Chen MK, Wei Y, Lee HH, Xia W, Wang YN, Yam C, Hsu JL, Wang HL, Chang WC, Yamaguchi H, Jiang Z, Liu C, Li CF, Nie L, Chan LC, Gao Y, Wang SC, Liu J, Westin SN, Lee S, Sood AK, Yang L, Hortobagyi GN, Yu D, Hung MC. Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex. Nat Cancer. 2022 10; 3(10):1211-1227. PMID: 36253486; PMCID: PMC9586872.
      Citations: 1     Fields:    Translation:HumansAnimals
    3. Li YC, Yamaguchi H, Liu YY, Hsu KC, Sun TH, Sun PC, Hung MC. Structural insights into EphA4 unconventional activation from prediction of the EphA4 and its complex with ribonuclease 1. Am J Cancer Res. 2022; 12(10):4865-4878. PMID: 36381327; PMCID: PMC9641407.
      Citations: 1     
    4. Yamaguchi H, Wang SC, Hung MC. Prospects of the potential strategies to improve the efficacy of anti-PD-1/PD-L1 therapy. Clin Transl Med. 2022 05; 12(5):e803. PMID: 35588146; PMCID: PMC9119611.
      Citations: 1     Fields:    Translation:Humans
    5. Jabbarzadeh Kaboli P, Shabani S, Sharma S, Partovi Nasr M, Yamaguchi H, Hung MC. Shedding light on triple-negative breast cancer with Trop2-targeted antibody-drug conjugates. Am J Cancer Res. 2022; 12(4):1671-1685. PMID: 35530278; PMCID: PMC9077081.
      Citations:    
    6. Yamaguchi H, Hsu JM, Yang WH, Hung MC. Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics. Nat Rev Clin Oncol. 2022 05; 19(5):287-305. PMID: 35132224.
      Citations: 2     Fields:    Translation:HumansCells
    7. Lee HH, Wang YN, Yang WH, Xia W, Wei Y, Chan LC, Wang YH, Jiang Z, Xu S, Yao J, Qiu Y, Hsu YH, Hwang WL, Yan M, Cha JH, Hsu JL, Shen J, Ye Y, Wu X, Hou MF, Tseng LM, Wang SC, Pan MR, Yang CH, Wang YL, Yamaguchi H, Pang D, Hortobagyi GN, Yu D, Hung MC. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nat Commun. 2021 05 13; 12(1):2788. PMID: 33986289; PMCID: PMC8119676.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    8. Jiang Z, Lim SO, Yan M, Hsu JL, Yao J, Wei Y, Chang SS, Yamaguchi H, Lee HH, Ke B, Hsu JM, Chan LC, Hortobagyi GN, Yang L, Lin C, Yu D, Hung MC. TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. J Clin Invest. 2021 04 15; 131(8). PMID: 33855973; PMCID: PMC8262501.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    9. Sovijit W, Sovijit W, Ishii Y, Kambe J, Fujita T, Watanabe G, Yamaguchi H, Nagaoka K. Estrogen promotes increased breast cancer cell proliferation and migration through downregulation of CPEB1 expression. Biochem Biophys Res Commun. 2021 01 01; 534:871-876. PMID: 33162033.
      Citations: 1     Fields:    Translation:HumansCells
    10. Yamaguchi H, Taouk GM. A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations. Front Oncol. 2020; 10:928. PMID: 32596154; PMCID: PMC7300268.
      Citations: 20     
    11. Chen Z, Yang Y, Yamaguchi H, Hung MC, Kameoka J. Isolation of cancer-derived extracellular vesicle subpopulations by a size-selective microfluidic platform. Biomicrofluidics. 2020 May; 14(3):034113. PMID: 32577148; PMCID: PMC7307647.
      Citations: 4     
    12. Chu YY, Yam C, Chen MK, Chan LC, Xiao M, Wei YK, Yamaguchi H, Lee PC, Han Y, Nie L, Sun X, Moulder SL, Hess KR, Wang B, Hsu JL, Hortobagyi GN, Litton J, Chang JT, Hung MC. Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer. Am J Cancer Res. 2020; 10(2):648-661. PMID: 32195033; PMCID: PMC7061756.
      Citations: 17     
    13. Nie L, Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, Huo L, Ko HW, Lin WC, Yamaguchi H, Hsu JM, Yang Y, Pan DN, Hsu JL, Kleer CG, Davidson NE, Hortobagyi GN, Hung MC. Author Correction: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. Nat Commun. 2020 Jan 29; 11(1):673. PMID: 31996688; PMCID: PMC6989459.
      Citations: 1     Fields:    
    14. Kambe J, Watcharin S, Makioka-Itaya Y, Inoue R, Watanabe G, Yamaguchi H, Nagaoka K. Heat-killed Enterococcus fecalis (EC-12) supplement alters the expression of neurotransmitter receptor genes in the prefrontal cortex and alleviates anxiety-like behavior in mice. Neurosci Lett. 2020 02 16; 720:134753. PMID: 31931033.
      Citations: 8     Fields:    Translation:AnimalsCells
    15. Kobayashi Y, Lim SO, Yamaguchi H. Oncogenic signaling pathways associated with immune evasion and resistance to immune checkpoint inhibitors in cancer. Semin Cancer Biol. 2020 10; 65:51-64. PMID: 31874279.
      Citations: 21     Fields:    Translation:HumansCells
    16. Saab S, Chang OS, Nagaoka K, Hung MC, Yamaguchi H. The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors. Am J Cancer Res. 2019; 9(12):2719-2729. PMID: 31911857; PMCID: PMC6943358.
      Citations: 5     
    17. Nie L, Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, Huo L, Ko HW, Lin WC, Yamaguchi H, Hsu JM, Yang Y, Pan DN, Hsu JL, Kleer CG, Davidson NE, Hortobagyi GN, Hung MC. CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. Nat Commun. 2019 11 08; 10(1):5114. PMID: 31704972; PMCID: PMC6841924.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    18. Chen Z, Yamaguchi H, Kameoka J. Development of size-selective microfluidic platform. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:5661-5664. PMID: 31947137.
      Citations: 1     Fields:    Translation:HumansCells
    19. Sovijit WN, Sovijit WE, Pu S, Usuda K, Inoue R, Watanabe G, Yamaguchi H, Nagaoka K. Ovarian progesterone suppresses depression and anxiety-like behaviors by increasing the Lactobacillus population of gut microbiota in ovariectomized mice. Neurosci Res. 2021 Jul; 168:76-82. PMID: 31022413.
      Citations: 10     Fields:    Translation:AnimalsCells
    20. Li H, Li CW, Li X, Ding Q, Guo L, Liu S, Liu C, Lai CC, Hsu JM, Dong Q, Xia W, Hsu JL, Yamaguchi H, Du Y, Lai YJ, Sun X, Koller PB, Ye Q, Hung MC. MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1. Gastroenterology. 2019 05; 156(6):1849-1861.e13. PMID: 30711629; PMCID: PMC6904924.
      Citations: 58     Fields:    Translation:AnimalsCells
    21. Wang WJ, Hsu JM, Wang YN, Lee HH, Yamaguchi H, Liao HW, Hung MC. An essential role of PRMT1-mediated EGFR methylation in EGFR activation by ribonuclease 5. Am J Cancer Res. 2019; 9(1):180-185. PMID: 30755821; PMCID: PMC6356926.
      Citations: 3     
    22. Dong Q, Du Y, Li H, Liu C, Wei Y, Chen MK, Zhao X, Chu YY, Qiu Y, Qin L, Yamaguchi H, Hung MC. EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma. Cancer Res. 2019 02 15; 79(4):819-829. PMID: 30573522; PMCID: PMC6886123.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    23. Lee PC, Fang YF, Yamaguchi H, Wang WJ, Chen TC, Hong X, Ke B, Xia W, Wei Y, Zha Z, Wang Y, Kuo HP, Wang CW, Tu CY, Chen CH, Huang WC, Chiang SF, Nie L, Hou J, Chen CT, Huo L, Yang WH, Deng R, Nakai K, Hsu YH, Chang SS, Chiu TJ, Tang J, Zhang R, Wang L, Fang B, Chen T, Wong KK, Hsu JL, Hung MC. Targeting PKCd as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer. Cancer Cell. 2018 12 10; 34(6):954-969.e4. PMID: 30537515; PMCID: PMC6886126.
      Citations: 26     Fields:    Translation:HumansCells
    24. Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, Perillo EP, Dunn AK, Kuo CW, Khoo KH, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Huang TH, Sahin AA, Hortobagyi GN, Yoo SS, Hung MC. Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1. Cancer Cell. 2018 02 12; 33(2):187-201.e10. PMID: 29438695; PMCID: PMC5824730.
      Citations: 151     Fields:    Translation:HumansAnimalsCells
    25. Huang PJ, Chou CK, Chen CT, Yamaguchi H, Qu J, Muliana A, Hung MC, Kameoka J. Pneumatically Actuated Soft Micromold Device for Fabricating Collagen and Matrigel Microparticles. Soft Robot. 2017 Dec; 4(4):390-399. PMID: 29251562.
      Citations: 1     Fields:    
    26. Nakai K, Xia W, Liao HW, Saito M, Hung MC, Yamaguchi H. The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells. Breast Cancer. 2018 Jan; 25(1):74-80. PMID: 28643125.
      Citations: 16     Fields:    Translation:HumansCells
    27. Jiao S, Xia W, Yamaguchi H, Wei Y, Chen MK, Hsu JM, Hsu JL, Yu WH, Du Y, Lee HH, Li CW, Chou CK, Lim SO, Chang SS, Litton J, Arun B, Hortobagyi GN, Hung MC. PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression. Clin Cancer Res. 2017 Jul 15; 23(14):3711-3720. PMID: 28167507; PMCID: PMC5511572.
      Citations: 311     Fields:    Translation:HumansAnimalsCells
    28. Lim SO, Li CW, Xia W, Cha JH, Chan LC, Wu Y, Chang SS, Lin WC, Hsu JM, Hsu YH, Kim T, Chang WC, Hsu JL, Yamaguchi H, Ding Q, Wang Y, Yang Y, Chen CH, Sahin AA, Yu D, Hortobagyi GN, Hung MC. Deubiquitination and Stabilization of PD-L1 by CSN5. Cancer Cell. 2016 Dec 12; 30(6):925-939. PMID: 27866850; PMCID: PMC5171205.
      Citations: 240     Fields:    Translation:HumansAnimalsCells
    29. Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC. Corrigendum: Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med. 2016 10 06; 22(10):1192. PMID: 27711065.
      Citations: 1     Fields:    
    30. Ko HW, Lee HH, Huo L, Xia W, Yang CC, Hsu JL, Li LY, Lai CC, Chan LC, Cheng CC, Labaff AM, Liao HW, Lim SO, Li CW, Wei Y, Nie L, Yamaguchi H, Hung MC. GSK3? inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers. Oncotarget. 2016 Aug 30; 7(35):57131-57144. PMID: 27494834; PMCID: PMC5302978.
      Citations: 20     Fields:    Translation:HumansCells
    31. Li CW, Lim SO, Xia W, Lee HH, Chan LC, Kuo CW, Khoo KH, Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Ding Q, Wang Y, Yao J, Lee CC, Wu HJ, Sahin AA, Allison JP, Yu D, Hortobagyi GN, Hung MC. Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. Nat Commun. 2016 08 30; 7:12632. PMID: 27572267; PMCID: PMC5013604.
      Citations: 292     Fields:    Translation:HumansAnimalsCells
    32. Nakai K, Hung MC, Yamaguchi H. A perspective on anti-EGFR therapies targeting triple-negative breast cancer. Am J Cancer Res. 2016; 6(8):1609-23. PMID: 27648353; PMCID: PMC5004067.
      Citations: 122     
    33. Hsu MC, Hung WC, Yamaguchi H, Lim SO, Liao HW, Tsai CH, Hung MC. Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway. Am J Cancer Res. 2016; 6(3):628-38. PMID: 27152240; PMCID: PMC4851842.
      Citations: 21     
    34. Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med. 2016 Feb; 22(2):194-201. PMID: 26779812; PMCID: PMC4754671.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    35. Li CW, Xia W, Lim SO, Hsu JL, Huo L, Wu Y, Li LY, Lai CC, Chang SS, Hsu YH, Sun HL, Kim J, Yamaguchi H, Lee DF, Wang H, Wang Y, Chou CK, Hsu JM, Lai YJ, LaBaff AM, Ding Q, Ko HW, Tsai FJ, Tsai CH, Hortobagyi GN, Hung MC. AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation. Cancer Res. 2016 Mar 15; 76(6):1451-62. PMID: 26759241; PMCID: PMC4794388.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    36. Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, Morelli MP, Sen M, Ladbury JE, Chen CH, Grandis JR, Kopetz S, Hung MC. PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. J Clin Invest. 2015 Dec; 125(12):4529-43. PMID: 26571401; PMCID: PMC4665782.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    37. Chen CT, Chen YC, Yamaguchi H, Hung MC. Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo. Am J Cancer Res. 2015; 5(12):3560-9. PMID: 26885446; PMCID: PMC4731631.
      Citations: 8     
    38. Yang CC, LaBaff A, Wei Y, Nie L, Xia W, Huo L, Yamaguchi H, Hsu YH, Hsu JL, Liu D, Lang J, Du Y, Lien HC, Li LY, Deng R, Chan LC, Yao J, Kleer CG, Hortobagyi GN, Hung MC. Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers. Am J Transl Res. 2015; 7(6):1009-20. PMID: 26279746; PMCID: PMC4532735.
      Citations: 23     
    39. Huo L, Li CW, Huang TH, Lam YC, Xia W, Tu C, Chang WC, Hsu JL, Lee DF, Nie L, Yamaguchi H, Wang Y, Lang J, Li LY, Chen CH, Mishra L, Hung MC. Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells. Am J Transl Res. 2014; 6(6):649-63. PMID: 25628777; PMCID: PMC4297334.
      Citations: 14     
    40. Yamaguchi H, Hung MC. Regulation and Role of EZH2 in Cancer. Cancer Res Treat. 2014 Jul; 46(3):209-22. PMID: 25038756; PMCID: PMC4132442.
      Citations: 129     Fields:    
    41. Chou CK, Lee HH, Tsou PH, Chen CT, Hsu JM, Yamaguchi H, Wang YN, Lee HJ, Hsu JL, Lee JF, Kameoka J, Hung MC. mMAPS: a flow-proteometric technique to analyze protein-protein interactions in individual signaling complexes. Sci Signal. 2014 Mar 04; 7(315):rs1. PMID: 24595109; PMCID: PMC4120848.
      Citations: 4     Fields:    Translation:Cells
    42. Yamaguchi H, Hsu JL, Chen CT, Wang YN, Hsu MC, Chang SS, Du Y, Ko HW, Herbst R, Hung MC. Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells. Clin Cancer Res. 2013 Feb 15; 19(4):845-54. PMID: 23344263; PMCID: PMC3703145.
      Citations: 36     Fields:    Translation:HumansCells
    43. Chen CT, Du Y, Yamaguchi H, Hsu JM, Kuo HP, Hortobagyi GN, Hung MC. Targeting the IKK?/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer. Mol Cancer Ther. 2012 Oct; 11(10):2212-21. PMID: 22826466; PMCID: PMC3712288.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    44. Hong S, Tsou PH, Chou CK, Yamaguchi H, Su CB, Hung MC, Kameoka J. Microfluidic three-dimensional hydrodynamic flow focusing for the rapid protein concentration analysis. Biomicrofluidics. 2012 Jun; 6(2):24132. PMID: 23785388; PMCID: PMC3391308.
      Citations: 2     
    45. Wang YN, Lee HH, Lee HJ, Du Y, Yamaguchi H, Hung MC. Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. J Biol Chem. 2012 May 11; 287(20):16869-79. PMID: 22451678; PMCID: PMC3351284.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    46. Yamaguchi H, Hsu JL, Hung MC. Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer. Front Oncol. 2012; 2:15. PMID: 22649777; PMCID: PMC3355968.
      Citations: 28     
    47. Li CW, Xia W, Huo L, Lim SO, Wu Y, Hsu JL, Chao CH, Yamaguchi H, Yang NK, Ding Q, Wang Y, Lai YJ, LaBaff AM, Wu TJ, Lin BR, Yang MH, Hortobagyi GN, Hung MC. Epithelial-mesenchymal transition induced by TNF-a requires NF-?B-mediated transcriptional upregulation of Twist1. Cancer Res. 2012 Mar 01; 72(5):1290-300. PMID: 22253230; PMCID: PMC3350107.
      Citations: 223     Fields:    Translation:HumansAnimalsCells
    48. Lang JY, Hsu JL, Meric-Bernstam F, Chang CJ, Wang Q, Bao Y, Yamaguchi H, Xie X, Woodward WA, Yu D, Hortobagyi GN, Hung MC. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell. 2011 Sep 13; 20(3):341-56. PMID: 21907925; PMCID: PMC3172580.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    49. Su JL, Cheng X, Yamaguchi H, Chang YW, Hou CF, Lee DF, Ko HW, Hua KT, Wang YN, Hsiao M, Chen PB, Hsu JM, Bast RC, Hortobagyi GN, Hung MC. FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization. Cancer Res. 2011 Nov 01; 71(21):6878-87. PMID: 21911455; PMCID: PMC3242367.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    50. Chen CT, Yamaguchi H, Lee HJ, Du Y, Lee HH, Xia W, Yu WH, Hsu JL, Yen CJ, Sun HL, Wang Y, Yeh ET, Hortobagyi GN, Hung MC. Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase. Mol Cancer Ther. 2011 Aug; 10(8):1327-36. PMID: 21610170; PMCID: PMC3155219.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    51. Wang YN, Yamaguchi H, Huo L, Du Y, Lee HJ, Lee HH, Wang H, Hsu JM, Hung MC. The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus. J Biol Chem. 2010 Dec 03; 285(49):38720-9. PMID: 20937808; PMCID: PMC2992305.
      Citations: 65     Fields:    Translation:HumansCells
    52. Hong S, Wang YN, Yamaguchi H, Sreenivasappa H, Chou CK, Tsou PH, Hung MC, Kameoka J. MEASUREMENT of Protein 53 Diffusion Coefficient in Live HeLa Cells Using Raster Image Correlation Spectroscopy (RICS). J Biomater Nanobiotechnol. 2010 Oct; 1(1):31-36. PMID: 21804949; PMCID: PMC3146256.
      Citations: 4     
    53. Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MC. Rapid detection of two-protein interaction with a single fluorophore by using a microfluidic device. Analyst. 2010 Nov; 135(11):2907-12. PMID: 20877860; PMCID: PMC3001224.
      Citations: 1     Fields:    Translation:HumansCells
    54. Wang YN, Wang H, Yamaguchi H, Lee HJ, Lee HH, Hung MC. COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport. Biochem Biophys Res Commun. 2010 Sep 03; 399(4):498-504. PMID: 20674546; PMCID: PMC2935258.
      Citations: 64     Fields:    Translation:HumansCells
    55. Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MC. High speed digital protein interaction analysis using microfluidic single molecule detection system. Lab Chip. 2010 Jul 21; 10(14):1793-8. PMID: 20498894; PMCID: PMC2919816.
      Citations: 4     Fields:    
    56. Chou CK, Lee DF, Sun HL, Li LY, Lin CY, Huang WC, Hsu JM, Kuo HP, Yamaguchi H, Wang YN, Liu M, Wu HY, Liao PC, Yen CJ, Hung MC. The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription. Mol Carcinog. 2009 Nov; 48(11):1048-58. PMID: 19526459; PMCID: PMC2783450.
      Citations: 13     Fields:    Translation:HumansCells
    57. Xie X, Hsu JL, Choi MG, Xia W, Yamaguchi H, Chen CT, Trinh BQ, Lu Z, Ueno NT, Wolf JK, Bast RC, Hung MC. A novel hTERT promoter-driven E1A therapeutic for ovarian cancer. Mol Cancer Ther. 2009 Aug; 8(8):2375-82. PMID: 19671744; PMCID: PMC2759534.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    58. Sun HL, Tsai AC, Pan SL, Ding Q, Yamaguchi H, Lin CN, Hung MC, Teng CM. EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation. Clin Cancer Res. 2009 Aug 01; 15(15):4904-14. PMID: 19622586.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    59. Yamaguchi H, Woods NT, Piluso LG, Lee HH, Chen J, Bhalla KN, Monteiro A, Liu X, Hung MC, Wang HG. p53 acetylation is crucial for its transcription-independent proapoptotic functions. J Biol Chem. 2009 Apr 24; 284(17):11171-83. PMID: 19265193; PMCID: PMC2670122.
      Citations: 66     Fields:    Translation:HumansCells
    60. Terrones O, Yamaguchi H, Landajuela A, Landeta O, Antonsson B, Wang HG, Etxebarria A, Basa?ez G. Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements. J Biol Chem. 2009 Feb 13; 284(7):4200-12. PMID: 19074440; PMCID: PMC3837389.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    61. Yamaguchi H, Ding Y, Lee JF, Zhang M, Pal A, Bornmann W, Yan DH, Hung MC. Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin. Mol Carcinog. 2008 Oct; 47(10):739-43. PMID: 18247378; PMCID: PMC2596649.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    62. Yamaguchi H, Woods NT, Dorsey JF, Takahashi Y, Gjertsen NR, Yeatman T, Wu J, Wang HG. SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis. J Biol Chem. 2008 Jul 04; 283(27):19112-8. PMID: 18474606; PMCID: PMC2441553.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    63. Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, Lang JY, Lai CC, Chang CJ, Huang WC, Huang H, Kuo HP, Lee DF, Li LY, Lien HC, Cheng X, Chang KJ, Hsiao CD, Tsai FJ, Tsai CH, Sahin AA, Muller WJ, Mills GB, Yu D, Hortobagyi GN, Hung MC. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol. 2008 Feb; 10(2):138-48. PMID: 18204439; PMCID: PMC2376808.
      Citations: 324     Fields:    Translation:HumansAnimalsCells
    64. Woods NT, Yamaguchi H, Lee FY, Bhalla KN, Wang HG. Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis. Cancer Res. 2007 Nov 15; 67(22):10744-52. PMID: 18006817; PMCID: PMC2258556.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    65. Yamaguchi H, Wang HG. Tissue transglutaminase serves as an inhibitor of apoptosis by cross-linking caspase 3 in thapsigargin-treated cells. Mol Cell Biol. 2006 Jan; 26(2):569-79. PMID: 16382148; PMCID: PMC1346894.
      Citations: 28     Fields:    Translation:HumansCells
    66. Takada N, Yamaguchi H, Shida K, Terajima D, Satou Y, Kasuya A, Satoh N, Satake M, Wang HG. The cell death machinery controlled by Bax and Bcl-XL is evolutionarily conserved in Ciona intestinalis. Apoptosis. 2005 Dec; 10(6):1211-20. PMID: 16215691.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    67. Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Youle RJ, Wang HG, Sebti SM. Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol. 2005 Nov; 25(21):9369-82. PMID: 16227588; PMCID: PMC1265816.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    68. Bali P, Pranpat M, Swaby R, Fiskus W, Yamaguchi H, Balasis M, Rocha K, Wang HG, Richon V, Bhalla K. Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2. Clin Cancer Res. 2005 Sep 01; 11(17):6382-9. PMID: 16144943.
      Citations: 67     Fields:    Translation:HumansCells
    69. Zheng Y, Yamaguchi H, Tian C, Lee MW, Tang H, Wang HG, Chen Q. Arsenic trioxide (As(2)O(3)) induces apoptosis through activation of Bax in hematopoietic cells. Oncogene. 2005 May 05; 24(20):3339-47. PMID: 15735709.
      Citations: 20     Fields:    Translation:HumansCells
    70. Yamaguchi H, Wang HG. CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem. 2004 Oct 29; 279(44):45495-502. PMID: 15322075.
      Citations: 347     Fields:    Translation:HumansCells
    71. Yamaguchi H, Chen J, Bhalla K, Wang HG. Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways. J Biol Chem. 2004 Sep 17; 279(38):39431-7. PMID: 15262986.
      Citations: 40     Fields:    Translation:HumansCells
    72. Antonsson B, Yamaguchi H, Wang HG, Liu J, Lee RM, Herrmann A, Terrones O, Basa?ez G. Lipidic pore formation by the concerted action of proapoptotic BAX and tBID. J Biol Chem. 2004 Jul 16; 279(29):30081-91. PMID: 15138279.
      Citations: 104     Fields:    Translation:AnimalsCells
    73. Nakayama J, Aoki D, Suga T, Akama TO, Ishizone S, Yamaguchi H, Imakawa K, Nadano D, Fazleabas AT, Katsuyama T, Nozawa S, Fukuda MN. Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy. Am J Pathol. 2003 Dec; 163(6):2211-9. PMID: 14633596; PMCID: PMC1892375.
      Citations: 12     Fields:    Translation:HumansCells
    74. Fuino L, Bali P, Wittmann S, Donapaty S, Guo F, Yamaguchi H, Wang HG, Atadja P, Bhalla K. Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B. Mol Cancer Ther. 2003 Oct; 2(10):971-84. PMID: 14578462.
      Citations: 74     Fields:    Translation:HumansCells
    75. Yamaguchi H, Bhalla K, Wang HG. Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. Cancer Res. 2003 Apr 01; 63(7):1483-9. PMID: 12670894.
      Citations: 35     Fields:    Translation:HumansCells
    76. Nimmanapalli R, O'Bryan E, Kuhn D, Yamaguchi H, Wang HG, Bhalla KN. Regulation of 17-AAG-induced apoptosis: role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated down-regulation of Akt, Raf-1, and Src kinases. Blood. 2003 Jul 01; 102(1):269-75. PMID: 12623837.
      Citations: 24     Fields:    Translation:HumansCells
    77. Wittmann S, Bali P, Donapaty S, Nimmanapalli R, Guo F, Yamaguchi H, Huang M, Jove R, Wang HG, Bhalla K. Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis. Cancer Res. 2003 Jan 01; 63(1):93-9. PMID: 12517783.
      Citations: 23     Fields:    Translation:HumansCells
    78. Yamaguchi H, Paranawithana SR, Lee MW, Huang Z, Bhalla KN, Wang HG. Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells. Cancer Res. 2002 Jan 15; 62(2):466-71. PMID: 11809697.
      Citations: 20     Fields:    Translation:HumansCells
    79. Yamaguchi H, Wang HG. The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene. 2001 Nov 22; 20(53):7779-86. PMID: 11753656.
      Citations: 119     Fields:    Translation:HumansCells
    80. Cuddeback SM, Yamaguchi H, Komatsu K, Miyashita T, Yamada M, Wu C, Singh S, Wang HG. Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax. J Biol Chem. 2001 Jun 08; 276(23):20559-65. PMID: 11259440.
      Citations: 72     Fields:    Translation:HumansCells
    81. Yamaguchi H, Nagaoka K, Imakawa K, Sakai S, Christenson RK. Enhancer regions of ovine interferon-tau gene that confer PMA response or cell type specific transcription. Mol Cell Endocrinol. 2001 Feb 28; 173(1-2):147-55. PMID: 11223186.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    82. Yamaguchi H, Katsumura M, Imakawa K, Sakai S, Christenson RK. Analysis of possible silencer elements of ovine interferon-tau gene. Endocr J. 2000 Apr; 47(2):137-42. PMID: 10943737.
      Citations:    Fields:    Translation:HumansAnimalsCells
    83. Yamaguchi H, Ikeda Y, Moreno JI, Katsumura M, Miyazawa T, Takahashi E, Imakawa K, Sakai S, Christenson RK. Identification of a functional transcriptional factor AP-1 site in the sheep interferon tau gene that mediates a response to PMA in JEG3 cells. Biochem J. 1999 Jun 15; 340 ( Pt 3):767-73. PMID: 10359663; PMCID: PMC1220310.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    84. Yamaguchi H, Ikeda Y, Taylor A, Katsumura M, Miyazawa T, Takahashi E, Imakawa K, Sakai S. Effects of PMA and transcription factors on ovine interferon-tau transactivation in various cell lines. Endocr J. 1999 Jun; 46(3):383-8. PMID: 10503990.
      Citations:    Fields:    Translation:HumansAnimalsCells
    85. Imakawa K, Ji Y, Yamaguchi H, Tamura K, Weber LW, Sakai S, Christenson RK. Co-expression of transforming growth factor beta and interferon tau during peri-implantation period in the ewe. Endocr J. 1998 Aug; 45(4):441-50. PMID: 9881892.
      Citations: 4     Fields:    Translation:Animals
    86. Mizoguchi Y, Yamaguchi H, Aoki F, Enami J, Sakai S. Corticosterone is required for the prolactin receptor gene expression in the late pregnant mouse mammary gland. Mol Cell Endocrinol. 1997 Sep 19; 132(1-2):177-83. PMID: 9324059.
      Citations: 15     Fields:    Translation:Animals
    87. Kim JY, Mizoguchi Y, Yamaguchi H, Enami J, Sakai S. Removal of milk by suckling acutely increases the prolactin receptor gene expression in the lactating mouse mammary gland. Mol Cell Endocrinol. 1997 Jul 04; 131(1):31-8. PMID: 9256361.
      Citations: 3     Fields:    Translation:Animals
    88. Ninomiya Y, Arao Y, Kometani T, Hiwatashi S, Yamasaki T, Erikawa T, Yamaguchi H, Hasegawa T, Masushige S, Kato S. Vitamin A is involved in estrogen-induced cell proliferation but not in cytodifferentiation of the chicken oviduct. J Endocrinol. 1996 Feb; 148(2):257-65. PMID: 8699140.
      Citations: 1     Fields:    Translation:Animals
    89. Development of automated high throughput single molecular microfluidic detection platform for signal transduction analysis.
    90. Phosphorylation of ezh2 at t416 by cdk2 contributes to the malignancy of triple negative breast cancers. American Journal of Translational Research. 7:1009-1020.
    91. A perspective on anti-EGFR therapies targeting triple-negative breast cancer. American Journal of Cancer Research. 6:1609-1623.
    92. GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers. Oncotarget. 7:57131-57144.
    93. Implantation in Ruminants. Asian-Australasian Journal of Animal Sciences. 13:845-855.
    94. Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer. Frontiers in Oncology. 2.
    95. Activation of keap1/nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells. American Journal of Translational Research. 6:649-663.
    96. Journal of Reproduction and Development. 47:69-82.
    97. Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. Nature Communications. 7.
    98. Regulation and role of EZH2 in cancer. Cancer Research and Treatment. 46:209-222.
    99. Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo. American Journal of Cancer Research. 5:3560-3569.
    100. Identification of interferon-tau at the maternal-fetal interface in Shiba goats. Journal of Reproduction and Development. 45:249-257.
    101. Deubiquitination and Stabilization of PD-L1 by CSN5. Cancer Cell. 30:925-939.
    102. Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway. American Journal of Cancer Research. 6:628-638.
    103. Aurora A kinase activates YAP signaling in triple-negative breast cancer. Oncogene.
    104. AKT1 inhibits epithelial-to-mesenchymal transition in breast cancer through phosphorylation-dependent twist1 degradation. Cancer Research. 76:1451-1462.
    105. PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. Journal of Clinical Investigation. 125:4529-4543.
    106. Nanofluidic Strategies for Cancer Research. 114-149.
    107. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nature Medicine. 22:194-201.
    YAMAGUCHI's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (463)
    Explore
    _
    Co-Authors (29)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _