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YAN XIA

TitleAssistant Professor
InstitutionMD Anderson
DepartmentNeuro-Oncology
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zheng Y, Li X, Qian X, Wang Y, Lee JH, Xia Y, Hawke DH, Zhang G, Lyu J, Lu Z. Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation. Nat Cell Biol. 2015 Oct; 17(10):1348-55. PMID: 26280537; PMCID: PMC4785887.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    2. Klein SR, Piya S, Lu Z, Xia Y, Alonso MM, White EJ, Wei J, Gomez-Manzano C, Jiang H, Fueyo J. C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy. Oncogene. 2015 Oct 08; 34(41):5295-301. PMID: 25619840; PMCID: PMC4515398.
      Citations: 24     Fields:    Translation:HumansCells
    3. Jiang Y, Li X, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, Lu Z. PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Mol Cell. 2014 Jan 09; 53(1):75-87. PMID: 24316223; PMCID: PMC3955203.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    4. Xia Y, Yang W, Bu W, Ji H, Zhao X, Zheng Y, Lin X, Li Y, Lu Z. Differential regulation of c-Jun protein plays an instrumental role in chemoresistance of cancer cells. J Biol Chem. 2013 Jul 05; 288(27):19321-9. PMID: 23678002; PMCID: PMC3707636.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    5. Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol. 2012 Dec; 14(12):1295-304. PMID: 23178880; PMCID: PMC3511602.
      Citations: 338     Fields:    Translation:HumansAnimalsCells
    6. Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K, Li Y, Verma IM, Chiao PJ, Lu Z. EGFR-induced and PKCe monoubiquitylation-dependent NF-?B activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell. 2012 Dec 14; 48(5):771-84. PMID: 23123196; PMCID: PMC3526114.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    7. Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell. 2012 Aug 17; 150(4):685-96. PMID: 22901803; PMCID: PMC3431020.
      Citations: 340     Fields:    Translation:HumansAnimalsCells
    8. Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z. Nuclear PKM2 regulates ?-catenin transactivation upon EGFR activation. Nature. 2011 Dec 01; 480(7375):118-22. PMID: 22056988; PMCID: PMC3235705.
      Citations: 452     Fields:    Translation:HumansAnimalsCells
    9. Zheng Y, Yang W, Xia Y, Hawke D, Liu DX, Lu Z. Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST. Mol Cell Biol. 2011 Nov; 31(21):4258-69. PMID: 21876001; PMCID: PMC3209333.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    10. Zheng Y, Xia Y, Hawke D, Halle M, Tremblay ML, Gao X, Zhou XZ, Aldape K, Cobb MH, Xie K, He J, Lu Z. FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell. 2009 Jul 10; 35(1):11-25. PMID: 19595712; PMCID: PMC2715139.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    11. Chen H, Xia Y, Fang D, Hawke D, Lu Z. Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. Mol Cell Biol. 2009 Jul; 29(13):3657-64. PMID: 19380486; PMCID: PMC2698753.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    12. Xia Y, Uhlin BE, Lindberg S, Sond?n B, G?ransson M, Hacker J. Regulatory Interactions among adhesin gene systems of uropathogenic Escherichia coli. Infect Immun. 2008 Feb; 76(2):771-80. PMID: 18039830; PMCID: PMC2223471.
      Citations: 22     Fields:    Translation:Cells
    13. Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, Mills GB, Kobayashi R, Hunter T, Lu Z. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem. 2007 Apr 13; 282(15):11221-9. PMID: 17287208; PMCID: PMC1850976.
      Citations: 411     Fields:    Translation:HumansAnimalsCells
    14. Xia Y, Wang J, Liu TJ, Yung WK, Hunter T, Lu Z. c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. Mol Cell. 2007 Jan 26; 25(2):219-32. PMID: 17244530; PMCID: PMC1829326.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    15. Xia Y, Wang J, Xu S, Johnson GL, Hunter T, Lu Z. MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol. 2007 Jan; 27(2):510-7. PMID: 17101801; PMCID: PMC1800814.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    16. Xia Y, Pao GM, Chen HW, Verma IM, Hunter T. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem. 2003 Feb 14; 278(7):5255-63. PMID: 12431996.
      Citations: 90     Fields:    Translation:HumansCells
    17. Gally D, Forsman-Semb K, Uhlin BE, Xia Y. Regulatory cross-talk between adhesin operons in Escherichia coli: inhibition of type 1 fimbriae expression by the PapB protein. EMBO J. 2000 Apr 03; 19(7):1450-7. PMID: 10747013; PMCID: PMC310214.
      Citations: 46     Fields:    Translation:HumansCells
    18. Forsman-Semb K, Jass J, Uhlin BE, Xia Y. Structural and functional studies of the fimbrial adhesin gene regulator PapB from uropathogenic Escherichia coli. Adv Exp Med Biol. 2000; 485:123-6. PMID: 11109096.
      Citations: 1     Fields:    Translation:HumansCells
    19. Balsalobre C, Forsman-Semb K, Jass J, Johansson J, Naureckiene S, Urbonaviciene J, Xia Y, Uhlin BE, G?ransson M, Sond?n B. Control mechanisms in the Pap-pili system. Adv Exp Med Biol. 2000; 485:113-8. PMID: 11109094.
      Citations:    Fields:    Translation:Cells
    20. Uhlin BE, Xia Y. Mutational analysis of the PapB transcriptional regulator in Escherichia coli. Regions important for DNA binding and oligomerization. J Biol Chem. 1999 Jul 09; 274(28):19723-30. PMID: 10391913.
      Citations: 7     Fields:    Translation:Cells
    21. Forsman K, Jass J, Uhlin BE, Xia Y. Oligomeric interaction of the PapB transcriptional regulator with the upstream activating region of pili adhesin gene promoters in Escherichia coli. Mol Microbiol. 1998 Nov; 30(3):513-23. PMID: 9822817.
      Citations: 12     Fields:    Translation:Cells
    22. Erratum. Nature Cell Biology. 18:709.
    23. EGFR phosphorylates FAM129B to promote Ras activation. Proceedings of the National Academy of Sciences of the United States of America. 113:644-649.
    24. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Molecular Cell. 61:705-719.
    25. PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nature Communications. 7.
    26. Erratum. Nature Cell Biology. 15:124.
    27. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nature Cell Biology. 18:561-571.
    28. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nature Cell Biology. 17:1158-1168.
    29. Erratum. Cell. 158:1210.
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