Keywords
Last Name
Institution

XANDER WEHRENS

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Physiology & Biophysics
AddressOne Baylor Plaza
Houston TX 77030
Other Positions
TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Cardiology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Respress JL, Gershovich PM, Wang T, Reynolds JO, Skapura DG, Sutton JP, Miyake CY, Wehrens XH. Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice. Int J Cardiol. 2014 Oct 20; 176(3):994-1000.
    View in: PubMed
  2. Di Carlo MN, Said M, Ling H, Valverde CA, De Giusti VC, Sommese L, Palomeque J, Aiello EA, Skapura DG, Rinaldi G, Respress JL, Brown JH, Wehrens XH, Salas MA, Mattiazzi A. CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol. 2014 Sep; 74:274-83.
    View in: PubMed
  3. Beavers DL, Landstrom AP, Chiang DY, Wehrens XH. Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases. Cardiovasc Res. 2014 Jul 15; 103(2):198-205.
    View in: PubMed
  4. Wang J, Bai Y, Li N, Ye W, Zhang M, Greene SB, Tao Y, Chen Y, Wehrens XH, Martin JF. Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9181-6.
    View in: PubMed
  5. Chiang DY, Li N, Wang Q, Alsina KM, Quick AP, Reynolds JO, Wang G, Skapura D, Voigt N, Dobrev D, Wehrens XH. Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation. Cardiovasc Res. 2014 Jul 1; 103(1):178-87.
    View in: PubMed
  6. Giudice J, Xia Z, Wang ET, Scavuzzo MA, Ward AJ, Kalsotra A, Wang W, Wehrens XH, Burge CB, Li W, Cooper TA. Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development. Nat Commun. 2014; 5:3603.
    View in: PubMed
  7. Dobrev D, Wehrens XH. Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias: Controversies Around Ryanodine Receptor Phosphorylation in Cardiac Disease. Circ Res. 2014 Apr 11; 114(8):1311-9.
    View in: PubMed
  8. Landstrom AP, Beavers DL, Wehrens XH. The junctophilin family of proteins: from bench to bedside. Trends Mol Med. 2014 Jun; 20(6):353-62.
    View in: PubMed
  9. Heijman J, Voigt N, Wehrens XH, Dobrev D. Calcium dysregulation in atrial fibrillation: the role of CaMKII. Front Pharmacol. 2014; 5:30.
    View in: PubMed
  10. Zhang C, Chen B, Guo A, Zhu Y, Miller JD, Gao S, Yuan C, Kutschke W, Zimmerman K, Weiss RM, Wehrens XH, Hong J, Johnson FL, Santana LF, Anderson ME, Song LS. Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure. Circulation. 2014 Apr 29; 129(17):1742-50.
    View in: PubMed
  11. Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Schmitz W, Müller FU, Valderrabano M, Nattel S, Dobrev D, Wehrens XH. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 2014 Mar 25; 129(12):1276-85.
    View in: PubMed
  12. Voigt N, Heijman J, Wang Q, Chiang DY, Li N, Karck M, Wehrens XH, Nattel S, Dobrev D. Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. Circulation. 2014 Jan 14; 129(2):145-56.
    View in: PubMed
  13. Ho HT, Liu B, Snyder JS, Lou Q, Brundage EA, Velez-Cortes F, Wang H, Ziolo MT, Anderson ME, Sen CK, Wehrens XH, Fedorov VV, Biesiadecki BJ, Hund TJ, Györke S. Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovasc Res. 2014 Jan 1; 101(1):165-74.
    View in: PubMed
  14. Gurha P, Wang T, Larimore AH, Sassi Y, Abreu-Goodger C, Ramirez MO, Reddy AK, Engelhardt S, Taffet GE, Wehrens XH, Entman ML, Rodriguez A. microRNA-22 Promotes Heart Failure through Coordinate Suppression of PPAR/ERR-Nuclear Hormone Receptor Transcription. PLoS One. 2013; 8(9):e75882.
    View in: PubMed
  15. Purohit A, Rokita AG, Guan X, Chen B, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak ED, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Wehrens XH, Song LS, Dobrev D, Maier LS, Anderson ME. Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation. 2013 Oct 15; 128(16):1748-57.
    View in: PubMed
  16. Beavers DL, Wang W, Ather S, Voigt N, Garbino A, Dixit SS, Landstrom AP, Li N, Wang Q, Olivotto I, Dobrev D, Ackerman MJ, Wehrens XH. Mutation E169K in Junctophilin-2 Causes Atrial Fibrillation Due to Impaired RyR2 Stabilization. J Am Coll Cardiol. 2013 Nov 19; 62(21):2010-9.
    View in: PubMed
  17. Chen B, Guo A, Zhang C, Chen R, Zhu Y, Hong J, Kutschke W, Zimmerman K, Weiss RM, Zingman L, Anderson ME, Wehrens XH, Song LS. Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development. Cardiovasc Res. 2013 Oct 1; 100(1):54-62.
    View in: PubMed
  18. Ather S, Respress JL, Li N, Wehrens XH. Alterations in ryanodine receptors and related proteins in heart failure. Biochim Biophys Acta. 2013 Dec; 1832(12):2425-31.
    View in: PubMed
  19. Wu SP, Cheng CM, Lanz RB, Wang T, Respress JL, Ather S, Chen W, Tsai SJ, Wehrens XH, Tsai MJ, Tsai SY. Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell. 2013 May 28; 25(4):417-26.
    View in: PubMed
  20. Reynolds JO, Chiang DY, Wang W, Beavers DL, Dixit SS, Skapura DG, Landstrom AP, Song LS, Ackerman MJ, Wehrens XH. Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. Cardiovasc Res. 2013 Oct 1; 100(1):44-53.
    View in: PubMed
  21. Wehrens XH, Chiang DY, Li N. Chronic exercise: a contributing factor to atrial fibrillation? J Am Coll Cardiol. 2013 Jul 2; 62(1):78-80.
    View in: PubMed
  22. Dixit SS, Wang T, Manzano EJ, Yoo S, Lee J, Chiang DY, Ryan N, Respress JL, Yechoor VK, Wehrens XH. Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance. PLoS One. 2013; 8(3):e58655.
    View in: PubMed
  23. Heijman J, Wehrens XH, Dobrev D. Atrial arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia--is there a mechanistic link between sarcoplasmic reticulum Ca(2+) leak and re-entry? Acta Physiol (Oxf). 2013 Feb; 207(2):208-11.
    View in: PubMed
  24. Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM. Epac2 mediates cardiac ß1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22.
    View in: PubMed
  25. Ather S, Wang W, Wang Q, Li N, Anderson ME, Wehrens XH. Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy. Heart Rhythm. 2013 Apr; 10(4):592-9.
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  26. Li N, Wehrens XH. Extinguishing intracellular calcium leak: a promising antiarrhythmic approach. Heart Rhythm. 2013 Jan; 10(1):108-9.
    View in: PubMed
  27. DeGrande S, Nixon D, Koval O, Curran JW, Wright P, Wang Q, Kashef F, Chiang D, Li N, Wehrens XH, Anderson ME, Hund TJ, Mohler PJ. CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm. 2012 Dec; 9(12):2034-41.
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  28. Wu Y, Luczak ED, Lee EJ, Hidalgo C, Yang J, Gao Z, Li J, Wehrens XH, Granzier H, Anderson ME. CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban. J Mol Cell Cardiol. 2012 Sep; 53(3):429-36.
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  29. Liu D, Huang L, Wang Y, Wang W, Wehrens XH, Belousova T, Abdelrahim M, DiMattia G, Sheikh-Hamad D. Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway. PLoS One. 2012; 7(5):e36994.
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  30. Ather S, Bavishi C, McCauley MD, Dhaliwal A, Deswal A, Johnson S, Chan W, Aguilar D, Pritchett AM, Ramasubbu K, Wehrens XH, Bozkurt B. Worsening renal function is not associated with response to treatment in acute heart failure. Int J Cardiol. 2013 Sep 1; 167(5):1912-7.
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  31. Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A. Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation. 2012 Jun 5; 125(22):2751-61.
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  32. Respress JL, van Oort RJ, Li N, Rolim N, Dixit SS, deAlmeida A, Voigt N, Lawrence WS, Skapura DG, Skårdal K, Wisløff U, Wieland T, Ai X, Pogwizd SM, Dobrev D, Wehrens XH. Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012 May 25; 110(11):1474-83.
    View in: PubMed
  33. Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XH, Dobrev D. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May 1; 125(17):2059-70.
    View in: PubMed
  34. Ather S, Chan W, Bozkurt B, Aguilar D, Ramasubbu K, Zachariah AA, Wehrens XH, Deswal A. Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction. J Am Coll Cardiol. 2012 Mar 13; 59(11):998-1005.
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  35. Jayasinghe ID, Baddeley D, Kong CH, Wehrens XH, Cannell MB, Soeller C. Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes. Biophys J. 2012 Mar 7; 102(5):L19-21.
    View in: PubMed
  36. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Mar 1; 483(7387):96-9.
    View in: PubMed
  37. McCauley MD, Wang T, Mike E, Herrera J, Beavers DL, Huang TW, Ward CS, Skinner S, Percy AK, Glaze DG, Wehrens XH, Neul JL. Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome. Sci Transl Med. 2011 Dec 14; 3(113):113ra125.
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  38. Li N, Wang T, Wang W, Cutler MJ, Wang Q, Voigt N, Rosenbaum DS, Dobrev D, Wehrens XH. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice. Circ Res. 2012 Feb 3; 110(3):465-70.
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  39. Wang T, Wehrens XH. Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform. Heart Rhythm. 2012 Apr; 9(4):598-9.
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  40. Kirchhof P, Marijon E, Fabritz L, Li N, Wang W, Wang T, Schulte K, Hanstein J, Schulte JS, Vogel M, Mougenot N, Laakmann S, Fortmueller L, Eckstein J, Verheule S, Kaese S, Staab A, Grote-Wessels S, Schotten U, Moubarak G, Wehrens XH, Schmitz W, Hatem S, Müller FU. Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. Int J Cardiol. 2013 Jun 20; 166(2):366-74.
    View in: PubMed
  41. Cunha SR, Hund TJ, Hashemi S, Voigt N, Li N, Wright P, Koval O, Li J, Gudmundsson H, Gumina RJ, Karck M, Schott JJ, Probst V, Le Marec H, Anderson ME, Dobrev D, Wehrens XH, Mohler PJ. Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation. 2011 Sep 13; 124(11):1212-22.
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  42. Said M, Becerra R, Valverde CA, Kaetzel MA, Dedman JR, Mundiña-Weilenmann C, Wehrens XH, Vittone L, Mattiazzi A. Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias. J Mol Cell Cardiol. 2011 Dec; 51(6):936-44.
    View in: PubMed
  43. McCauley MD, Wehrens XH. Targeting ryanodine receptors for anti-arrhythmic therapy. Acta Pharmacol Sin. 2011 Jun; 32(6):749-57.
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  44. Ather S, Chan W, Chillar A, Aguilar D, Pritchett AM, Ramasubbu K, Wehrens XH, Deswal A, Bozkurt B. Association of systolic blood pressure with mortality in patients with heart failure with reduced ejection fraction: a complex relationship. Am Heart J. 2011 Mar; 161(3):567-73.
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  45. van Oort RJ, Garbino A, Wang W, Dixit SS, Landstrom AP, Gaur N, De Almeida AC, Skapura DG, Rudy Y, Burns AR, Ackerman MJ, Wehrens XH. Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation. 2011 Mar 8; 123(9):979-88.
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  46. McCauley MD, Wehrens XH. Ryanodine receptor phosphorylation, calcium/calmodulin-dependent protein kinase II, and life-threatening ventricular arrhythmias. Trends Cardiovasc Med. 2011 Feb; 21(2):48-51.
    View in: PubMed
  47. Landstrom AP, Kellen CA, Dixit SS, van Oort RJ, Garbino A, Weisleder N, Ma J, Wehrens XH, Ackerman MJ. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circ Heart Fail. 2011 Mar; 4(2):214-23.
    View in: PubMed
  48. van Oort RJ, McCauley MD, Dixit SS, Pereira L, Yang Y, Respress JL, Wang Q, De Almeida AC, Skapura DG, Anderson ME, Bers DM, Wehrens XH. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation. 2010 Dec 21; 122(25):2669-79.
    View in: PubMed
  49. Dobrev D, Voigt N, Wehrens XH. The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovasc Res. 2011 Mar 1; 89(4):734-43.
    View in: PubMed
  50. Wehrens XH. CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart Rhythm. 2011 Feb; 8(2):323-5.
    View in: PubMed
  51. Garbino A, Wehrens XH. Emerging role of junctophilin-2 as a regulator of calcium handling in the heart. Acta Pharmacol Sin. 2010 Sep; 31(9):1019-21.
    View in: PubMed
  52. Sarma S, Li N, van Oort RJ, Reynolds C, Skapura DG, Wehrens XH. Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13165-70.
    View in: PubMed
  53. Respress JL, Wehrens XH. Transthoracic echocardiography in mice. J Vis Exp. 2010; (39).
    View in: PubMed
  54. McCauley MD, Wehrens XH. Ambulatory ECG recording in mice. J Vis Exp. 2010; (39).
    View in: PubMed
  55. Li N, Wehrens XH. Programmed electrical stimulation in mice. J Vis Exp. 2010; (39).
    View in: PubMed
  56. Ather S, Peterson LE, Divakaran VG, Deswal A, Ramasubbu K, Giorgberidze I, Blaustein A, Wehrens XH, Mann DL, Bozkurt B. Digoxin treatment in heart failure--unveiling risk by cluster analysis of DIG data. Int J Cardiol. 2011 Aug 4; 150(3):264-9.
    View in: PubMed
  57. Wang J, Klysik E, Sood S, Johnson RL, Wehrens XH, Martin JF. Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9753-8.
    View in: PubMed
  58. deAlmeida AC, van Oort RJ, Wehrens XH. Transverse aortic constriction in mice. J Vis Exp. 2010; (38).
    View in: PubMed
  59. van Oort RJ, Respress JL, Li N, Reynolds C, De Almeida AC, Skapura DG, De Windt LJ, Wehrens XH. Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension. 2010 Apr; 55(4):932-8.
    View in: PubMed
  60. Wang W, Wehrens XH. Stress synchronizes calcium release and promotes SR calcium leak. J Physiol. 2010 Feb 1; 588(Pt 3):391-2.
    View in: PubMed
  61. Koshelev M, Sarma S, Price RE, Wehrens XH, Cooper TA. Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1. Hum Mol Genet. 2010 Mar 15; 19(6):1066-75.
    View in: PubMed
  62. Dobrev D, Wehrens XH. Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation. Trends Cardiovasc Med. 2010 Jan; 20(1):30-4.
    View in: PubMed
  63. Mathur N, Sood S, Wang S, van Oort RJ, Sarma S, Li N, Skapura DG, Bayle JH, Valderrábano M, Wehrens XH. Sudden infant death syndrome in mice with an inherited mutation in RyR2. Circ Arrhythm Electrophysiol. 2009 Dec; 2(6):677-85.
    View in: PubMed
  64. Wang GS, Kuyumcu-Martinez MN, Sarma S, Mathur N, Wehrens XH, Cooper TA. PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1. J Clin Invest. 2009 Dec; 119(12):3797-806.
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  65. McCauley MD, Wehrens XH. Animal models of arrhythmogenic cardiomyopathy. Dis Model Mech. 2009 Nov-Dec; 2(11-12):563-70.
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  66. Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul; 119(7):1940-51.
    View in: PubMed
  67. Garbino A, van Oort RJ, Dixit SS, Landstrom AP, Ackerman MJ, Wehrens XH. Molecular evolution of the junctophilin gene family. Physiol Genomics. 2009 May 13; 37(3):175-86.
    View in: PubMed
  68. Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009 Apr 7; 106(14):5972-7.
    View in: PubMed
  69. Shao CH, Wehrens XH, Wyatt TA, Parbhu S, Rozanski GJ, Patel KP, Bidasee KR. Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. J Appl Physiol (1985). 2009 Apr; 106(4):1280-92.
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  70. Lalani SR, Thakuria JV, Cox GF, Wang X, Bi W, Bray MS, Shaw C, Cheung SW, Chinault AC, Boggs BA, Ou Z, Brundage EK, Lupski JR, Gentile J, Waisbren S, Pursley A, Ma L, Khajavi M, Zapata G, Friedman R, Kim JJ, Towbin JA, Stankiewicz P, Schnittger S, Hansmann I, Ai T, Sood S, Wehrens XH, Martin JF, Belmont JW, Potocki L. 20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits. J Med Genet. 2009 Mar; 46(3):168-75.
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  71. van Oort RJ, Altamirano J, Lederer WJ, Wehrens XH. Alternative splicing: a key mechanism for ankyrin-B functional diversity? J Mol Cell Cardiol. 2008 Dec; 45(6):709-11.
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  72. Bourajjaj M, Armand AS, da Costa Martins PA, Weijts B, van der Nagel R, Heeneman S, Wehrens XH, De Windt LJ. NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure. J Biol Chem. 2008 Aug 8; 283(32):22295-303.
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  73. Sood S, Chelu MG, van Oort RJ, Skapura D, Santonastasi M, Dobrev D, Wehrens XH. Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm. 2008 Jul; 5(7):1047-54.
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  74. Chelu MG, Wehrens XH. Sarcoplasmic reticulum calcium leak and cardiac arrhythmias. Biochem Soc Trans. 2007 Nov; 35(Pt 5):952-6.
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  75. Mohler PJ, Wehrens XH. Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions. Physiology (Bethesda). 2007 Oct; 22:342-50.
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  76. Wehrens XH. Istaroxime, a novel luso-inotropic agent for the treatment of acute heart failure. Curr Opin Investig Drugs. 2007 Sep; 8(9):769-77.
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  77. Clancy CE, Wehrens XH. Mutation-specific effects of lidocaine in Brugada syndrome. Int J Cardiol. 2007 Oct 18; 121(3):249-52.
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  78. Chen-Izu Y, Ward CW, Stark W, Banyasz T, Sumandea MP, Balke CW, Izu LT, Wehrens XH. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2409-17.
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  79. Santonastasi M, Wehrens XH. Ryanodine receptors as pharmacological targets for heart disease. Acta Pharmacol Sin. 2007 Jul; 28(7):937-44.
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  80. Wehrens XH. Leaky ryanodine receptors cause delayed afterdepolarizations and ventricular arrhythmias. Eur Heart J. 2007 May; 28(9):1054-6.
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  81. van Oort RJ, Wehrens XH. Subcellular targeting of phosphatases: a novel function of ankyrins. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H15-6.
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  82. Landstrom AP, Weisleder N, Batalden KB, Bos JM, Tester DJ, Ommen SR, Wehrens XH, Claycomb WC, Ko JK, Hwang M, Pan Z, Ma J, Ackerman MJ. Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. J Mol Cell Cardiol. 2007 Jun; 42(6):1026-35.
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  83. Durham WJ, Wehrens XH, Sood S, Hamilton SL. Diseases associated with altered ryanodine receptor activity. Subcell Biochem. 2007; 45:273-321.
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  84. Wehrens XH. The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms? Heart Rhythm. 2007 Jun; 4(6):794-7.
    View in: PubMed
  85. Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, Kearney DL, Danila CI, De Biasi M, Wehrens XH, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, Hamilton SL. Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A. 2006 Aug 8; 103(32):12179-84.
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  86. Lehnart SE, Terrenoire C, Reiken S, Wehrens XH, Song LS, Tillman EJ, Mancarella S, Coromilas J, Lederer WJ, Kass RS, Marks AR. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7906-10.
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  87. Huang F, Shan J, Reiken S, Wehrens XH, Marks AR. Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3456-61.
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  88. Wehrens XH, Lehnart SE, Reiken S, Vest JA, Wronska A, Marks AR. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):511-8.
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  89. Wehrens XH. Structural determinants of potassium channel blockade and drug-induced arrhythmias. Handb Exp Pharmacol. 2006; (171):123-57.
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  90. Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 2005 Oct 7; 123(1):25-35.
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  91. Lehnart SE, Wehrens XH, Marks AR. Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure. Circulation. 2005 Jun 28; 111(25):3342-6.
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  92. Wehrens XH, Lehnart SE, Reiken S, van der Nagel R, Morales R, Sun J, Cheng Z, Deng SX, de Windt LJ, Landry DW, Marks AR. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A. 2005 Jul 5; 102(27):9607-12.
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  93. Wehrens XH, Lehnart SE, Marks AR. Ryanodine receptor-targeted anti-arrhythmic therapy. Ann N Y Acad Sci. 2005 Jun; 1047:366-75.
    View in: PubMed
  94. Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 2005 Apr 26; 111(16):2025-32.
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  95. Wehrens XH, Lehnart SE, Marks AR. Intracellular calcium release and cardiac disease. Annu Rev Physiol. 2005; 67:69-98.
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  96. Wehrens XH, Marks AR. Sudden unexplained death caused by cardiac ryanodine receptor (RyR2) mutations. Mayo Clin Proc. 2004 Nov; 79(11):1367-71.
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  97. Lehnart SE, Wehrens XH, Marks AR. Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochem Biophys Res Commun. 2004 Oct 1; 322(4):1267-79.
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  98. Wehrens XH, Marks AR. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov. 2004 Jul; 3(7):565-73.
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  99. Lehnart SE, Wehrens XH, Laitinen PJ, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR. Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation. 2004 Jun 29; 109(25):3208-14.
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  100. Wehrens XH, Doevendans PA. Cardiac rupture complicating myocardial infarction. Int J Cardiol. 2004 Jun; 95(2-3):285-92.
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  101. Lehnart SE, Wehrens XH, Kushnir A, Marks AR. Cardiac ryanodine receptor function and regulation in heart disease. Ann N Y Acad Sci. 2004 May; 1015:144-59.
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  102. Wehrens XH, Lehnart SE, Reiken SR, Deng SX, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science. 2004 Apr 9; 304(5668):292-6.
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  103. Wehrens XH, Lehnart SE, Reiken SR, Marks AR. Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004 Apr 2; 94(6):e61-70.
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  104. Wehrens XH, Offermans JP, Snijders M, Peeters LL. Fetal cardiovascular response to large placental chorioangiomas. J Perinat Med. 2004; 32(2):107-12.
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  105. Wehrens XH, Marks AR. Molecular determinants of altered contractility in heart failure. Ann Med. 2004; 36 Suppl 1:70-80.
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  106. Wehrens XH, Marks AR. Altered function and regulation of cardiac ryanodine receptors in cardiac disease. Trends Biochem Sci. 2003 Dec; 28(12):671-8.
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  107. Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, D'Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, Marks AR. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell. 2003 Jun 27; 113(7):829-40.
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  108. Wehrens XH, Doevendans PA. Cardiac rupture. N Engl J Med. 2003 May 29; 348(22):2264.
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  109. Reiken S, Wehrens XH, Vest JA, Barbone A, Klotz S, Mancini D, Burkhoff D, Marks AR. Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation. 2003 May 20; 107(19):2459-66.
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  110. Wehrens XH, Rossenbacker T, Jongbloed RJ, Gewillig M, Heidbüchel H, Doevendans PA, Vos MA, Wellens HJ, Kass RS. A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating. Hum Mutat. 2003 May; 21(5):552.
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  111. Clancy CE, Tateyama M, Liu H, Wehrens XH, Kass RS. Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation. 2003 May 6; 107(17):2233-7.
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  112. Wehrens XH, Vos MA, Doevendans PA, Wellens HJ. Novel insights in the congenital long QT syndrome. Ann Intern Med. 2002 Dec 17; 137(12):981-92.
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  113. Buehler A, Martire A, Strohm C, Wolfram S, Fernandez B, Palmen M, Wehrens XH, Doevendans PA, Franz WM, Schaper W, Zimmermann R. Angiogenesis-independent cardioprotection in FGF-1 transgenic mice. Cardiovasc Res. 2002 Sep; 55(4):768-77.
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  114. oude Egbrink MG, Janssen GH, Ookawa K, Slaaf DW, Reneman RS, Wehrens XH, Maaijwee KJ, Ohshima N, Struijker Boudier HA, Tangelder GJ. Especially polymorphonuclear leukocytes, but also monomorphonuclear leukocytes, roll spontaneously in venules of intact rat skin: involvement of E-selectin. J Invest Dermatol. 2002 Feb; 118(2):323-6.
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  115. Wehrens XH, Rouwet EV, oude Egbrink MG, Slaaf DW, Ramsay G. Effects of experimental lower-limb ischaemia-reperfusion injury on the mesenteric microcirculation. Br J Surg. 2002 Feb; 89(2):185-91.
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  116. Clancy CE, Kurokawa J, Tateyama M, Wehrens XH, Kass RS. K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation. Annu Rev Pharmacol Toxicol. 2003; 43:441-61.
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  117. Wehrens XH, Marks AR. Myocardial disease in failing hearts: defective excitation-contraction coupling. Cold Spring Harb Symp Quant Biol. 2002; 67:533-41.
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  118. Wehrens XH, Leiner T. Publications from extracurricular research. Lancet. 2001 Sep 8; 358(9284):846.
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  119. Wehrens XH, Doevendans PA, Widdershoven JW, Dassen WR, Prenger K, Wellens HJ, Gorgels AP. Usefulness of sinus tachycardia and ST-segment elevation in V(5) to identify impending left ventricular free wall rupture in inferior wall myocardial infarction. Am J Cardiol. 2001 Aug 15; 88(4):414-7.
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  120. Dammers R, Wehrens XH, oude Egbrink MG, Slaaf DW, Kurvers HA, Ramsay G. Microcirculatory effects of experimental acute limb ischaemia-reperfusion. Br J Surg. 2001 Jun; 88(6):816-24.
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  121. Abriel H, Cabo C, Wehrens XH, Rivolta I, Motoike HK, Memmi M, Napolitano C, Priori SG, Kass RS. Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel. Circ Res. 2001 Apr 13; 88(7):740-5.
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  122. Wehrens XH, Doevendans PA. [Primary osteomyelitis of sternum]. Ned Tijdschr Geneeskd. 2001 Feb 3; 145(5):245-6.
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  123. Wehrens XH, van Breda E, van Velzen JS, oude Egbrink MG, Slaaf DW. Use of an intact mouse skeletal muscle preparation for endocrine vascular studies: evaluation of the model. Horm Metab Res. 2000 Sep; 32(9):378-80.
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  124. Abriel H, Wehrens XH, Benhorin J, Kerem B, Kass RS. Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome. Circulation. 2000 Aug 22; 102(8):921-5.
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  125. Wehrens XH, Abriel H, Cabo C, Benhorin J, Kass RS. Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na(+) channel alpha-subunit: A computational analysis. Circulation. 2000 Aug 1; 102(5):584-90.
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  126. Wehrens XH, Doevendans PA, Ophuis TJ, Wellens HJ. A comparison of electrocardiographic changes during reperfusion of acute myocardial infarction by thrombolysis or percutaneous transluminal coronary angioplasty. Am Heart J. 2000 Mar; 139(3):430-6.
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  127. Wehrens XH, Kirchhoff S, Doevendans PA. Mouse electrocardiography: an interval of thirty years. Cardiovasc Res. 2000 Jan 1; 45(1):231-7.
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  128. Wehrens XH, Mies B, Gimona M, Ramaekers FC, Van Eys GJ, Small JV. Localization of smoothelin in avian smooth muscle and identification of a vascular-specific isoform. FEBS Lett. 1997 Apr 1; 405(3):315-20.
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  129. van Eys GJ, Völler MC, Timmer ED, Wehrens XH, Small JV, Schalken JA, Ramaekers FC, van der Loop FT. Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant. Cell Struct Funct. 1997 Feb; 22(1):65-72.
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  130. Wehrens XH, Doevendans PA, van Dantzig JM, Snoep G, Wellens HJ. Infected sternal fracture hematoma after cardiopulmonary resuscitation initially seen as pericarditis. Am Heart J. 1996 Sep; 132(3):685-6.
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