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ROBERT A WATERLAND

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Nutrition
Address1100 BATES STREET
PEDIATRICS - NUTRITION
HOUSTON TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Garland T, Cadney MD, Waterland RA. Early-Life Effects on Adult Physical Activity: Concepts, Relevance, and Experimental Approaches. Physiol Biochem Zool. 2017 Jan/Feb; 90(1):1-14. PMID: 28051947.
      View in: PubMed
    2. Kühnen P, Handke D, Waterland RA, Hennig BJ, Silver M, Fulford AJ, Dominguez-Salas P, Moore SE, Prentice AM, Spranger J, Hinney A, Hebebrand J, Heppner FL, Walzer L, Grötzinger C, Gromoll J, Wiegand S, Grüters A, Krude H. Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity. Cell Metab. 2016 Sep 13; 24(3):502-9. PMID: 27568547.
      View in: PubMed
    3. Estill MS, Bolnick JM, Waterland RA, Bolnick AD, Diamond MP, Krawetz SA. Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of newborn infants. Fertil Steril. 2016 Sep 1; 106(3):629-639.e10. PMID: 27288894.
      View in: PubMed
    4. Sutton EF, Gilmore LA, Dunger DB, Heijmans BT, Hivert MF, Ling C, Martinez JA, Ozanne SE, Simmons RA, Szyf M, Waterland RA, Redman LM, Ravussin E. Developmental programming: State-of-the-science and future directions-Summary from a Pennington Biomedical symposium. Obesity (Silver Spring). 2016 May; 24(5):1018-26. PMID: 27037645; PMCID: PMC4846483 [Available on 05/01/17].
    5. Eclarinal JD, Zhu S, Baker MS, Piyarathna DB, Coarfa C, Fiorotto ML, Waterland RA. Maternal exercise during pregnancy promotes physical activity in adult offspring. FASEB J. 2016 Jul; 30(7):2541-8. PMID: 27033262.
      View in: PubMed
    6. Kessler NJ, Van Baak TE, Baker MS, Laritsky E, Coarfa C, Waterland RA. CpG methylation differences between neurons and glia are highly conserved from mouse to human. Hum Mol Genet. 2016 Jan 15; 25(2):223-32. PMID: 26566671.
      View in: PubMed
    7. Zhu S, Eclarinal J, Baker MS, Li G, Waterland RA. Developmental programming of energy balance regulation: is physical activity more 'programmable' than food intake? Proc Nutr Soc. 2016 Feb; 75(1):73-77. PMID: 26511431.
      View in: PubMed
    8. Yu DH, Gadkari M, Zhou Q, Yu S, Gao N, Guan Y, Schady D, Roshan TN, Chen MH, Laritsky E, Ge Z, Wang H, Chen R, Westwater C, Bry L, Waterland RA, Moriarty C, Hwang C, Swennes AG, Moore SR, Shen L. Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome. Genome Biol. 2015; 16:211. PMID: 26420038.
      View in: PubMed
    9. Silver MJ, Kessler NJ, Hennig BJ, Dominguez-Salas P, Laritsky E, Baker MS, Coarfa C, Hernandez-Vargas H, Castelino JM, Routledge MN, Gong YY, Herceg Z, Lee YS, Lee K, Moore SE, Fulford AJ, Prentice AM, Waterland RA. Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment. Genome Biol. 2015; 16:118. PMID: 26062908.
      View in: PubMed
    10. Wahlqvist ML, Krawetz SA, Rizzo NS, Dominguez-Bello MG, Szymanski LM, Barkin S, Yatkine A, Waterland RA, Mennella JA, Desai M, Ross MG, Krebs NF, Young BE, Wardle J, Wrann CD, Kral JG. Early-life influences on obesity: from preconception to adolescence. Ann N Y Acad Sci. 2015 Jul; 1347:1-28. PMID: 26037603.
      View in: PubMed
    11. Integrative analysis of 111 reference human epigenomes. Nature. 2015 Feb 19; 518(7539):317-30. PMID: 25693563; PMCID: PMC4530010.
    12. Yu DH, Waterland RA, Shen L. On the meaning of the word 'epimutation': a comment. Trends Genet. 2015 Jan; 31(1):1. PMID: 25480537.
      View in: PubMed
    13. Yu DH, Waterland RA, Zhang P, Schady D, Chen MH, Guan Y, Gadkari M, Shen L. Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice. J Clin Invest. 2014 Sep; 124(9):3708-12. PMID: 25061879; PMCID: PMC4151219.
    14. Waterland RA. Epigenetic mechanisms affecting regulation of energy balance: many questions, few answers. Annu Rev Nutr. 2014; 34:337-55. PMID: 24850387.
      View in: PubMed
    15. Dominguez-Salas P, Moore SE, Baker MS, Bergen AW, Cox SE, Dyer RA, Fulford AJ, Guan Y, Laritsky E, Silver MJ, Swan GE, Zeisel SH, Innis SM, Waterland RA, Prentice AM, Hennig BJ. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nat Commun. 2014; 5:3746. PMID: 24781383; PMCID: PMC4015319.
    16. Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring). 2014 Feb; 22 Suppl 1:S1-S17. PMID: 24574081; PMCID: PMC4159941.
    17. Kunde-Ramamoorthy G, Coarfa C, Laritsky E, Kessler NJ, Harris RA, Xu M, Chen R, Shen L, Milosavljevic A, Waterland RA. Comparison and quantitative verification of mapping algorithms for whole-genome bisulfite sequencing. Nucleic Acids Res. 2014 Apr; 42(6):e43. PMID: 24391148; PMCID: PMC3973287.
    18. Li G, Zhang W, Baker MS, Laritsky E, Mattan-Hung N, Yu D, Kunde-Ramamoorthy G, Simerly RB, Chen R, Shen L, Waterland RA. Major epigenetic development distinguishing neuronal and non-neuronal cells occurs postnatally in the murine hypothalamus. Hum Mol Genet. 2014 Mar 15; 23(6):1579-90. PMID: 24186871; PMCID: PMC3929094.
    19. Baker MS, Li G, Kohorst JJ, Waterland RA. Fetal growth restriction promotes physical inactivity and obesity in female mice. Int J Obes (Lond). 2015 Jan; 39(1):98-104. PMID: 23924758; PMCID: PMC3872504.
    20. Dominguez-Salas P, Moore SE, Cole D, da Costa KA, Cox SE, Dyer RA, Fulford AJ, Innis SM, Waterland RA, Zeisel SH, Prentice AM, Hennig BJ. DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. Am J Clin Nutr. 2013 Jun; 97(6):1217-27. PMID: 23576045; PMCID: PMC3652920.
    21. Li G, Kohorst JJ, Zhang W, Laritsky E, Kunde-Ramamoorthy G, Baker MS, Fiorotto ML, Waterland RA. Early postnatal nutrition determines adult physical activity and energy expenditure in female mice. Diabetes. 2013 Aug; 62(8):2773-83. PMID: 23545705; PMCID: PMC3717861.
    22. Yu DH, Ware C, Waterland RA, Zhang J, Chen MH, Gadkari M, Kunde-Ramamoorthy G, Nosavanh LM, Shen L. Developmentally programmed 3' CpG island methylation confers tissue- and cell-type-specific transcriptional activation. Mol Cell Biol. 2013 May; 33(9):1845-58. PMID: 23459939; PMCID: PMC3624169.
    23. Zeisel SH, Waterland RA, Ordovás JM, Muoio DM, Jia W, Fodor A. Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research. JPEN J Parenter Enteral Nutr. 2013 Mar; 37(2):190-200. PMID: 23042849; PMCID: PMC3593226.
    24. Romagnolo DF, Dashwood R, Stover PJ, Waterland RA, Ziegler TR. Nutritional regulation of epigenetic changes. Adv Nutr. 2012; 3(5):749-50. PMID: 22983864; PMCID: PMC3648767.
    25. Brand S, Teich R, Dicke T, Harb H, Yildirim AÖ, Tost J, Schneider-Stock R, Waterland RA, Bauer UM, von Mutius E, Garn H, Pfefferle PI, Renz H. Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes. J Allergy Clin Immunol. 2011 Sep; 128(3):618-25.e1-7. PMID: 21680015.
      View in: PubMed
    26. Waterland RA, Kellermayer R, Laritsky E, Rayco-Solon P, Harris RA, Travisano M, Zhang W, Torskaya MS, Zhang J, Shen L, Manary MJ, Prentice AM. Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet. 2010; 6(12):e1001252. PMID: 21203497; PMCID: PMC3009670.
    27. Hochberg Z, Feil R, Constancia M, Fraga M, Junien C, Carel JC, Boileau P, Le Bouc Y, Deal CL, Lillycrop K, Scharfmann R, Sheppard A, Skinner M, Szyf M, Waterland RA, Waxman DJ, Whitelaw E, Ong K, Albertsson-Wikland K. Child health, developmental plasticity, and epigenetic programming. Endocr Rev. 2011 Apr; 32(2):159-224. PMID: 20971919; PMCID: PMC3365792.
    28. Harris RA, Wang T, Coarfa C, Nagarajan RP, Hong C, Downey SL, Johnson BE, Fouse SD, Delaney A, Zhao Y, Olshen A, Ballinger T, Zhou X, Forsberg KJ, Gu J, Echipare L, O'Geen H, Lister R, Pelizzola M, Xi Y, Epstein CB, Bernstein BE, Hawkins RD, Ren B, Chung WY, Gu H, Bock C, Gnirke A, Zhang MQ, Haussler D, Ecker JR, Li W, Farnham PJ, Waterland RA, Meissner A, Marra MA, Hirst M, Milosavljevic A, Costello JF. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol. 2010 Oct; 28(10):1097-105. PMID: 20852635; PMCID: PMC2955169.
    29. Kellermayer R, Balasa A, Zhang W, Lee S, Mirza S, Chakravarty A, Szigeti R, Laritsky E, Tatevian N, Smith CW, Shen L, Waterland RA. Epigenetic maturation in colonic mucosa continues beyond infancy in mice. Hum Mol Genet. 2010 Jun 1; 19(11):2168-76. PMID: 20197410; PMCID: PMC2865374.
    30. Waterland RA. Early environmental effects on epigenetic regulation in humans. Epigenetics. 2009 Nov 16; 4(8):523-5. PMID: 19923895.
      View in: PubMed
    31. McAllister EJ, Dhurandhar NV, Keith SW, Aronne LJ, Barger J, Baskin M, Benca RM, Biggio J, Boggiano MM, Eisenmann JC, Elobeid M, Fontaine KR, Gluckman P, Hanlon EC, Katzmarzyk P, Pietrobelli A, Redden DT, Ruden DM, Wang C, Waterland RA, Wright SM, Allison DB. Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr. 2009 Nov; 49(10):868-913. PMID: 19960394; PMCID: PMC2932668.
    32. Waterland RA, Kellermayer R, Rached MT, Tatevian N, Gomes MV, Zhang J, Zhang L, Chakravarty A, Zhu W, Laritsky E, Zhang W, Wang X, Shen L. Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development. Hum Mol Genet. 2009 Aug 15; 18(16):3026-38. PMID: 19457928; PMCID: PMC2714727.
    33. Waterland RA. Is epigenetics an important link between early life events and adult disease? Horm Res. 2009 Jan; 71 Suppl 1:13-6. PMID: 19153498.
      View in: PubMed
    34. Waterland RA. Epigenetic epidemiology of obesity: application of epigenomic technology. Nutr Rev. 2008 Aug; 66 Suppl 1:S21-3. PMID: 18673482.
      View in: PubMed
    35. Waterland RA, Travisano M, Tahiliani KG, Rached MT, Mirza S. Methyl donor supplementation prevents transgenerational amplification of obesity. Int J Obes (Lond). 2008 Sep; 32(9):1373-9. PMID: 18626486; PMCID: PMC2574783.
    36. Dion V, Lin Y, Hubert L, Waterland RA, Wilson JH. Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline. Hum Mol Genet. 2008 May 1; 17(9):1306-17. PMID: 18252747; PMCID: PMC3686304.
    37. Gomes MV, Waterland RA. Individual epigenetic variation: when, why, and so what? Nestle Nutr Workshop Ser Pediatr Program. 2008; 62:141-50; discussion 151-5. PMID: 18626198.
      View in: PubMed
    38. Benbrahim-Tallaa L, Waterland RA, Dill AL, Webber MM, Waalkes MP. Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase. Environ Health Perspect. 2007 Oct; 115(10):1454-9. PMID: 17938735; PMCID: PMC2022656.
    39. Shen L, Kondo Y, Guo Y, Zhang J, Zhang L, Ahmed S, Shu J, Chen X, Waterland RA, Issa JP. Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet. 2007 Oct; 3(10):2023-36. PMID: 17967063; PMCID: PMC2041996.
    40. Shen L, Waterland RA. Methods of DNA methylation analysis. Curr Opin Clin Nutr Metab Care. 2007 Sep; 10(5):576-81. PMID: 17693740.
      View in: PubMed
    41. Waterland RA, Travisano M, Tahiliani KG. Diet-induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female. FASEB J. 2007 Oct; 21(12):3380-5. PMID: 17551099.
      View in: PubMed
    42. Waterland RA, Michels KB. Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr. 2007; 27:363-88. PMID: 17465856.
      View in: PubMed
    43. Waterland RA. Epigenetic mechanisms and gastrointestinal development. J Pediatr. 2006 Nov; 149(5 Suppl):S137-42. PMID: 17212956.
      View in: PubMed
    44. Waterland RA, Dolinoy DC, Lin JR, Smith CA, Shi X, Tahiliani KG. Maternal methyl supplements increase offspring DNA methylation at Axin Fused. Genesis. 2006 Sep; 44(9):401-6. PMID: 16868943.
      View in: PubMed
    45. Waterland RA. Assessing the effects of high methionine intake on DNA methylation. J Nutr. 2006 Jun; 136(6 Suppl):1706S-1710S. PMID: 16702343.
      View in: PubMed
    46. Dolinoy DC, Weidman JR, Waterland RA, Jirtle RL. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect. 2006 Apr; 114(4):567-72. PMID: 16581547; PMCID: PMC1440782.
    47. Waterland RA, Lin JR, Smith CA, Jirtle RL. Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum Mol Genet. 2006 Mar 1; 15(5):705-16. PMID: 16421170.
      View in: PubMed
    48. Timme-Laragy AR, Meyer JN, Waterland RA, Di Giulio RT. Analysis of CpG methylation in the killifish CYP1A promoter. Comp Biochem Physiol C Toxicol Pharmacol. 2005 Aug; 141(4):406-11. PMID: 16257583.
      View in: PubMed
    49. Benbrahim-Tallaa L, Waterland RA, Styblo M, Achanzar WE, Webber MM, Waalkes MP. Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol Appl Pharmacol. 2005 Aug 15; 206(3):288-98. PMID: 16039940.
      View in: PubMed
    50. Waterland RA. Commentary: The global relevance of "biological Freudianism". Int J Epidemiol. 2005 Feb; 34(1):15-7. PMID: 15649966.
      View in: PubMed
    51. Waterland RA. Does nutrition during infancy and early childhood contribute to later obesity via metabolic imprinting of epigenetic gene regulatory mechanisms? Nestle Nutr Workshop Ser Pediatr Program. 2005; 56:157-71; discussion 171-4. PMID: 16632951.
      View in: PubMed
    52. Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition. 2004 Jan; 20(1):63-8. PMID: 14698016.
      View in: PubMed
    53. Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. 2003 Aug; 23(15):5293-300. PMID: 12861015; PMCID: PMC165709.
    54. Waterland RA. Do maternal methyl supplements in mice affect DNA methylation of offspring? J Nutr. 2003 Jan; 133(1):238; author reply 239. PMID: 12514298.
      View in: PubMed
    55. Wylie AA, Pulford DJ, McVie-Wylie AJ, Waterland RA, Evans HK, Chen YT, Nolan CM, Orton TC, Jirtle RL. Tissue-specific inactivation of murine M6P/IGF2R. Am J Pathol. 2003 Jan; 162(1):321-8. PMID: 12507915; PMCID: PMC1851115.
    56. Oka Y, Waterland RA, Killian JK, Nolan CM, Jang HS, Tohara K, Sakaguchi S, Yao T, Iwashita A, Yata Y, Takahara T, Sato S, Suzuki K, Masuda T, Jirtle RL. M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan. Hepatology. 2002 May; 35(5):1153-63. PMID: 11981765.
      View in: PubMed
    57. Waterland RA, Garza C. Early postnatal nutrition determines adult pancreatic glucose-responsive insulin secretion and islet gene expression in rats. J Nutr. 2002 Mar; 132(3):357-64. PMID: 11880555.
      View in: PubMed
    58. Killian JK, Oka Y, Jang HS, Fu X, Waterland RA, Sohda T, Sakaguchi S, Jirtle RL. Mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) variants in American and Japanese populations. Hum Mutat. 2001; 18(1):25-31. PMID: 11438990.
      View in: PubMed
    59. Waterland RA, Garza C. Potential mechanisms of metabolic imprinting that lead to chronic disease. Am J Clin Nutr. 1999 Feb; 69(2):179-97. PMID: 9989679.
      View in: PubMed
    60. Waterland RA, Berkowitz RI, Stunkard AJ, Stallings VA. Calibrated-orifice nipples for measurement of infant nutritive sucking. J Pediatr. 1998 Mar; 132(3 Pt 1):523-6. PMID: 9544914.
      View in: PubMed
    61. Basu A, Yin M, Waterland RA, Chance B. Kinetics of ligand binding of cytochrome oxidases: a comparative study. Biochim Biophys Acta. 1994 Mar 8; 1184(2-3):291-5. PMID: 8130254.
      View in: PubMed
    62. Waterland RA, Basu A, Chance B, Poyton RO. The isoforms of yeast cytochrome c oxidase subunit V alter the in vivo kinetic properties of the holoenzyme. J Biol Chem. 1991 Mar 5; 266(7):4180-6. PMID: 1847916.
      View in: PubMed
    63. Chance B, Waterland RA, Tanaka A, Poyton RO. Mitochondrial function in normal and genetically altered cells and tissues. Ann N Y Acad Sci. 1988; 550:360-73. PMID: 3072898.
      View in: PubMed
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