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MARGARET A GOODELL

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Hem/Onc Cell & Gene The
AddressCenter for Cell & Gene Therapy
One Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Cell & Gene Therapy
    DivisionCenter for Cell & Gene Therapy

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionImmunology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Brunetti L, Gundry MC, Goodell MA. DNMT3A in Leukemia. Cold Spring Harb Perspect Med. 2016 Dec 21. PMID: 28003281.
      View in: PubMed
    2. Gundry MC, Brunetti L, Lin A, Mayle AE, Kitano A, Wagner D, Hsu JI, Hoegenauer KA, Rooney CM, Goodell MA, Nakada D. Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. Cell Rep. 2016 Oct 25; 17(5):1453-1461. PMID: 27783956.
      View in: PubMed
    3. Karlstaedt A, Zhang X, Vitrac H, Harmancey R, Vasquez H, Wang JH, Goodell MA, Taegtmeyer H. Oncometabolite d-2-hydroxyglutarate impairs ?-ketoglutarate dehydrogenase and contractile function in rodent heart. Proc Natl Acad Sci U S A. 2016 Sep 13; 113(37):10436-41. PMID: 27582470.
      View in: PubMed
    4. Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Göttgens B, Lee JS, Rau R, Li W, Goodell MA. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell. 2016 Aug 08; 30(2):363-365. PMID: 27505680.
      View in: PubMed
    5. Zhang X, Su J, Jeong M, Ko M, Huang Y, Park HJ, Guzman A, Lei Y, Huang YH, Rao A, Li W, Goodell MA. DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells. Nat Genet. 2016 Sep; 48(9):1014-23. PMID: 27428748; PMCID: PMC4957136 [Available on 03/01/17].
    6. Eckstein OS, Wang L, Punia JN, Kornblau SM, Andreeff M, Wheeler DA, Goodell MA, Rau RE. Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes. Exp Hematol. 2016 May 18. PMID: 27208809.
      View in: PubMed
    7. Jeong M, Goodell MA. Noncoding Regulatory RNAs in Hematopoiesis. Curr Top Dev Biol. 2016; 118:245-70. PMID: 27137659.
      View in: PubMed
    8. Goodell MA, Rando TA. Stem cells and healthy aging. Science. 2015 Dec 4; 350(6265):1199-204. PMID: 26785478.
      View in: PubMed
    9. An J, González-Avalos E, Chawla A, Jeong M, López-Moyado IF, Li W, Goodell MA, Chavez L, Ko M, Rao A. Acute loss of TET function results in aggressive myeloid cancer in mice. Nat Commun. 2015; 6:10071. PMID: 26607761.
      View in: PubMed
    10. Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vigneau S, Kozlitina J, Yetman MJ, Jankowsky JL, Reichardt SD, Reichardt HM, Gärtner J, Bartolomei MS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Huppke P, Neul JL, Bedalov A, Pieper AA. Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 2015 Sep 24; 525(7570):552. PMID: 26176914.
      View in: PubMed
    11. King KY, Matatall KA, Shen CC, Goodell MA, Swierczek SI, Prchal JT. Comparative long-term effects of interferon ? and hydroxyurea on human hematopoietic progenitor cells. Exp Hematol. 2015 Oct; 43(10):912-918.e2. PMID: 26072330.
      View in: PubMed
    12. Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Muñoz-Cánoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y. Stem Cells and Aging: What's Next? Cell Stem Cell. 2015 Jun 4; 16(6):578-81. PMID: 26247067.
      View in: PubMed
    13. Gibson BW, Boles NC, Souroullas GP, Herron AJ, Fraley JK, Schwiebert RS, Sharp JJ, Goodell MA. Comparison of Cesium-137 and X-ray Irradiators by Using Bone Marrow Transplant Reconstitution in C57BL/6J Mice. Comp Med. 2015 Jun; 65(3):165-72. PMID: 26141441.
      View in: PubMed
    14. Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vigneau S, Kozlitina J, Yetman MJ, Jankowsky JL, Reichardt SD, Reichardt HM, Gärtner J, Bartolomei MS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Huppke P, Neul JL, Bedalov A, Pieper AA. Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 2015 May 21; 521(7552):E1-4. PMID: 25993969.
      View in: PubMed
    15. Goodell MA, Nguyen H, Shroyer N. Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments. Nat Rev Mol Cell Biol. 2015 May; 16(5):299-309. PMID: 25907613.
      View in: PubMed
    16. Luo M, Jeong M, Sun D, Park HJ, Rodriguez BA, Xia Z, Yang L, Zhang X, Sheng K, Darlington GJ, Li W, Goodell MA. Long non-coding RNAs control hematopoietic stem cell function. Cell Stem Cell. 2015 Apr 2; 16(4):426-38. PMID: 25772072; PMCID: PMC4388783.
    17. Goodell M. Introduction to a review series on hematopoietic stem cells. Blood. 2015 Apr 23; 125(17):2587. PMID: 25762178.
      View in: PubMed
    18. Yang L, Rau R, Goodell MA. DNMT3A in haematological malignancies. Nat Rev Cancer. 2015 Mar; 15(3):152-65. PMID: 25693834.
      View in: PubMed
    19. Mayle A, Yang L, Rodriguez B, Zhou T, Chang E, Curry CV, Challen GA, Li W, Wheeler D, Rebel VI, Goodell MA. Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Blood. 2015 Jan 22; 125(4):629-38. PMID: 25416277; PMCID: PMC4304108.
    20. Cullen SM, Goodell MA. Dynamic DNA methylation discovered during HSC differentiation. Cell Cycle. 2015; 14(5):693-4. PMID: 25714123; PMCID: PMC4418287.
    21. Challen GA, Sun D, Mayle A, Jeong M, Luo M, Rodriguez B, Mallaney C, Celik H, Yang L, Xia Z, Cullen S, Berg J, Zheng Y, Darlington GJ, Li W, Goodell MA. Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell. 2014 Sep 4; 15(3):350-64. PMID: 25130491; PMCID: PMC4163922.
    22. Jeong M, Goodell MA. New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells. Exp Hematol. 2014 Aug; 42(8):609-17. PMID: 24993071; PMCID: PMC4137036.
    23. Goodell MA. A gallon of sweat to make a pint of blood. J Exp Med. 2014 Jun 30; 211(7):1271-2. PMID: 24980745; PMCID: PMC4076594.
    24. Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TA. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature. 2014 Jun 19; 510(7505):393-6. PMID: 24870234; PMCID: PMC4065227.
    25. Sun D, Luo M, Jeong M, Rodriguez B, Xia Z, Hannah R, Wang H, Le T, Faull KF, Chen R, Gu H, Bock C, Meissner A, Göttgens B, Darlington GJ, Li W, Goodell MA. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell. 2014 May 1; 14(5):673-88. PMID: 24792119; PMCID: PMC4070311.
    26. Sun D, Xi Y, Rodriguez B, Park HJ, Tong P, Meong M, Goodell MA, Li W. MOABS: model based analysis of bisulfite sequencing data. Genome Biol. 2014; 15(2):R38. PMID: 24565500; PMCID: PMC4054608.
    27. Cullen SM, Mayle A, Rossi L, Goodell MA. Hematopoietic stem cell development: an epigenetic journey. Curr Top Dev Biol. 2014; 107:39-75. PMID: 24439802.
      View in: PubMed
    28. Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet. 2014 Jan; 46(1):17-23. PMID: 24270360; PMCID: PMC3920905.
    29. Kim SJ, Zhao H, Hardikar S, Singh AK, Goodell MA, Chen T. A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells. Blood. 2013 Dec 12; 122(25):4086-9. PMID: 24167195; PMCID: PMC3952368.
    30. Goodell MA. Parental permissions: H19 and keeping the stem cell progeny under control. Cell Stem Cell. 2013 Aug 1; 13(2):137-8. PMID: 23910078.
      View in: PubMed
    31. Shi FT, Kim H, Lu W, He Q, Liu D, Goodell MA, Wan M, Songyang Z. Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells. J Biol Chem. 2013 Jul 19; 288(29):20776-84. PMID: 23729667; PMCID: PMC3774349.
    32. Cullen SM, Goodell MA. Rising from the crypt: decreasing DNA methylation during differentiation of the small intestine. Genome Biol. 2013; 14(5):116. PMID: 23714004; PMCID: PMC4053750.
    33. Goodell MA, Godley LA. Perspectives and future directions for epigenetics in hematology. Blood. 2013 Jun 27; 121(26):5131-7. PMID: 23692857; PMCID: PMC3695360.
    34. Kahle JJ, Souroullas GP, Yu P, Zohren F, Lee Y, Shaw CA, Zoghbi HY, Goodell MA. Ataxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discovery. PLoS Genet. 2013 Mar; 9(3):e1003359. PMID: 23555280; PMCID: PMC3610904.
    35. Ergen AV, Jeong M, Lin KK, Challen GA, Goodell MA. Isolation and characterization of mouse side population cells. Methods Mol Biol. 2013; 946:151-62. PMID: 23179831.
      View in: PubMed
    36. Rossi L, Lemoli RM, Goodell MA. Gpr171, a putative P2Y-like receptor, negatively regulates myeloid differentiation in murine hematopoietic progenitors. Exp Hematol. 2013 Jan; 41(1):102-12. PMID: 23022127; PMCID: PMC3525765.
    37. Rossi L, Lin KK, Boles NC, Yang L, King KY, Jeong M, Mayle A, Goodell MA. Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell. 2012 Sep 7; 11(3):302-17. PMID: 22958929; PMCID: PMC3461270.
    38. Zohren F, Souroullas GP, Luo M, Gerdemann U, Imperato MR, Wilson NK, Göttgens B, Lukov GL, Goodell MA. The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors. Nat Immunol. 2012 Aug; 13(8):761-9. PMID: 22772404; PMCID: PMC3411897.
    39. Mayle A, Luo M, Jeong M, Goodell MA. Flow cytometry analysis of murine hematopoietic stem cells. Cytometry A. 2013 Jan; 83(1):27-37. PMID: 22736515; PMCID: PMC3638885.
    40. Li J, Harris RA, Cheung SW, Coarfa C, Jeong M, Goodell MA, White LD, Patel A, Kang SH, Shaw C, Chinault AC, Gambin T, Gambin A, Lupski JR, Milosavljevic A. Genomic hypomethylation in the human germline associates with selective structural mutability in the human genome. PLoS Genet. 2012; 8(5):e1002692. PMID: 22615578; PMCID: PMC3355074.
    41. James RA, Rao MM, Chen ES, Goodell MA, Shaw CA. The Hematopoietic Expression Viewer: expanding mobile apps as a scientific tool. Bioinformatics. 2012 Jul 15; 28(14):1941-2. PMID: 22576171; PMCID: PMC3491999.
    42. Ergen AV, Boles NC, Goodell MA. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood. 2012 Mar 15; 119(11):2500-9. PMID: 22289892; PMCID: PMC3311273.
    43. Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2012 Jan; 44(1):23-31. PMID: 22138693; PMCID: PMC3637952.
    44. Berg JS, Lin KK, Sonnet C, Boles NC, Weksberg DC, Nguyen H, Holt LJ, Rickwood D, Daly RJ, Goodell MA. Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells. PLoS One. 2011; 6(10):e26410. PMID: 22039481; PMCID: PMC3198398.
    45. Challen GA, Goodell MA. Bridge over troubled stem cells. Mol Ther. 2011 Oct; 19(10):1756-8. PMID: 21964307; PMCID: PMC3188750.
    46. Lin KK, Rossi L, Boles NC, Hall BE, George TC, Goodell MA. CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway. PLoS Biol. 2011 Sep; 9(9):e1001148. PMID: 21931533; PMCID: PMC3172193.
    47. King KY, Goodell MA. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol. 2011 Oct; 11(10):685-92. PMID: 21904387; PMCID: PMC4154310.
    48. King KY, Baldridge MT, Weksberg DC, Chambers SM, Lukov GL, Wu S, Boles NC, Jung SY, Qin J, Liu D, Songyang Z, Eissa NT, Taylor GA, Goodell MA. Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood. 2011 Aug 11; 118(6):1525-33. PMID: 21633090; PMCID: PMC3156044.
    49. Souroullas GP, Goodell MA. A new allele of Lyl1 confirms its important role in hematopoietic stem cell function. Genesis. 2011 Jun; 49(6):441-8. PMID: 21387538; PMCID: PMC3115471.
    50. Boles NC, Lin KK, Lukov GL, Bowman TV, Baldridge MT, Goodell MA. CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation. Blood. 2011 Jul 7; 118(1):80-7. PMID: 21576698; PMCID: PMC3139389.
    51. Rossi L, Ergen AV, Goodell MA. TIMP-1 deficiency subverts cell-cycle dynamics in murine long-term HSCs. Blood. 2011 Jun 16; 117(24):6479-88. PMID: 21521782; PMCID: PMC3123018.
    52. Liao J, Hammerick KE, Challen GA, Goodell MA, Kasper FK, Mikos AG. Investigating the role of hematopoietic stem and progenitor cells in regulating the osteogenic differentiation of mesenchymal stem cells in vitro. J Orthop Res. 2011 Oct; 29(10):1544-53. PMID: 21495066; PMCID: PMC3150621.
    53. King KY, Goodell MA. Direct conversion of skin cells into blood: alchemy or science? Mol Ther. 2011 Feb; 19(2):227-8. PMID: 21289635; PMCID: PMC3034862.
    54. King KY, Lew JD, Ha NP, Lin JS, Ma X, Graviss EA, Goodell MA. Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans. PLoS One. 2011; 6(1):e16317. PMID: 21283700; PMCID: PMC3025014.
    55. Baldridge MT, King KY, Goodell MA. Inflammatory signals regulate hematopoietic stem cells. Trends Immunol. 2011 Feb; 32(2):57-65. PMID: 21233016; PMCID: PMC3042730.
    56. Rossi L, Challen GA, Sirin O, Lin KK, Goodell MA. Hematopoietic stem cell characterization and isolation. Methods Mol Biol. 2011; 750:47-59. PMID: 21618082; PMCID: PMC3621966.
    57. Sirin O, Lukov GL, Mao R, Conneely OM, Goodell MA. The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells. Nat Cell Biol. 2010 Dec; 12(12):1213-9. PMID: 21076412; PMCID: PMC3059561.
    58. Lukov GL, Goodell MA. LYL1 degradation by the proteasome is directed by a N-terminal PEST rich site in a phosphorylation-independent manner. PLoS One. 2010; 5(9). PMID: 20844761; PMCID: PMC2937031.
    59. Lukov GL, Rossi L, Souroullas GP, Mao R, Goodell MA. The expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation. Leuk Res. 2011 Mar; 35(3):405-12. PMID: 20705338; PMCID: PMC2980862.
    60. Baldridge MT, King KY, Boles NC, Weksberg DC, Goodell MA. Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature. 2010 Jun 10; 465(7299):793-7. PMID: 20535209; PMCID: PMC2935898.
    61. Challen GA, Boles NC, Chambers SM, Goodell MA. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell. 2010 Mar 5; 6(3):265-78. PMID: 20207229; PMCID: PMC2837284.
    62. Challen GA, Goodell MA. Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells. Exp Hematol. 2010 May; 38(5):403-16. PMID: 20206228; PMCID: PMC2854264.
    63. Foster AE, Okur FV, Biagi E, Lu A, Dotti G, Yvon E, Savoldo B, Carrum G, Goodell MA, Heslop HE, Brenner MK. Selective elimination of a chemoresistant side population of B-CLL cells by cytotoxic T lymphocytes in subjects receiving an autologous hCD40L/IL-2 tumor vaccine. Leukemia. 2010 Mar; 24(3):563-72. PMID: 20072155; PMCID: PMC2836398.
    64. Boles NC, Peddibhotla S, Chen AJ, Goodell MA, Rosen JM. Chk1 haploinsufficiency results in anemia and defective erythropoiesis. PLoS One. 2010; 5(1):e8581. PMID: 20052416; PMCID: PMC2798715.
    65. Ergen AV, Goodell MA. Mechanisms of hematopoietic stem cell aging. Exp Gerontol. 2010 Apr; 45(4):286-90. PMID: 20034552; PMCID: PMC3632712.
    66. Sharabi AB, Lee SH, Goodell MA, Huang XF, Chen SY. Enhanced generation of myeloid lineages in hematopoietic differentiation from embryonic stem cells by silencing transcriptional repressor Twist-2. Cloning Stem Cells. 2009 Dec; 11(4):523-33. PMID: 20025523; PMCID: PMC2883497.
    67. Foster AE, Okur FV, Biagi E, Lu A, Dotti G, Yvon E, Savoldo B, Carrum G, Andreeff M, Goodell MA, Heslop HE, Brenner MK. Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression. Mol Cancer. 2009; 8:106. PMID: 19922650; PMCID: PMC2784756.
    68. Vieyra DS, Rosen A, Goodell MA. Identification and characterization of side population cells in embryonic stem cell cultures. Stem Cells Dev. 2009 Oct; 18(8):1155-66. PMID: 19113897; PMCID: PMC3136721.
    69. Souroullas GP, Salmon JM, Sablitzky F, Curtis DJ, Goodell MA. Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell. 2009 Feb 6; 4(2):180-6. PMID: 19200805; PMCID: PMC2672304.
    70. Challen GA, Boles N, Lin KK, Goodell MA. Mouse hematopoietic stem cell identification and analysis. Cytometry A. 2009 Jan; 75(1):14-24. PMID: 19023891; PMCID: PMC2640229.
    71. Challen GA, Goodell MA. Promiscuous expression of H2B-GFP transgene in hematopoietic stem cells. PLoS One. 2008; 3(6):e2357. PMID: 18523660; PMCID: PMC2408727.
    72. Feng CG, Weksberg DC, Taylor GA, Sher A, Goodell MA. The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell. 2008 Jan 10; 2(1):83-9. PMID: 18371424; PMCID: PMC2278017.
    73. Weksberg DC, Chambers SM, Boles NC, Goodell MA. CD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells. Blood. 2008 Feb 15; 111(4):2444-51. PMID: 18055867; PMCID: PMC2234069.
    74. Chambers SM, Boles NC, Lin KY, Tierney MP, Bowman TV, Bradfute SB, Chen AJ, Merchant AA, Sirin O, Weksberg DC, Merchant MG, Fisk CJ, Shaw CA, Goodell MA. Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell. 2007 Nov; 1(5):578-91. PMID: 18371395; PMCID: PMC2475548.
    75. Yankelevich M, Goodell MA, Kaplan J. Efficacy of delayed administration of post-chemotherapy granulocyte colony-stimulating factor: evidence from murine studies of bone marrow cell kinetics. Exp Hematol. 2008 Jan; 36(1):9-16. PMID: 17949891; PMCID: PMC2223182.
    76. Berg JS, Goodell MA. An argument against a role for Oct4 in somatic stem cells. Cell Stem Cell. 2007 Oct 11; 1(4):359-60. PMID: 18371372.
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    77. Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA, Goodell MA. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol. 2007 Aug; 5(8):e201. PMID: 17676974; PMCID: PMC1925137.
    78. Vieyra DS, Goodell MA. Pluripotentiality and conditional transgene regulation in human embryonic stem cells expressing insulated tetracycline-ON transactivator. Stem Cells. 2007 Oct; 25(10):2559-66. PMID: 17628023.
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    79. Jolicoeur EM, Granger CB, Fakunding JL, Mockrin SC, Grant SM, Ellis SG, Weisel RD, Goodell MA. Bringing cardiovascular cell-based therapy to clinical application: perspectives based on a National Heart, Lung, and Blood Institute Cell Therapy Working Group meeting. Am Heart J. 2007 May; 153(5):732-42. PMID: 17452146.
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    80. Bowman TV, Merchant AA, Goodell MA. Molecular profiling of hematopoietic stem cells. Methods Mol Med. 2007; 134:1-16. PMID: 17666739.
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    81. Chambers SM, Goodell MA. Hematopoietic stem cell aging: wrinkles in stem cell potential. Stem Cell Rev. 2007; 3(3):201-11. PMID: 17917133.
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    82. Kustikova OS, Geiger H, Li Z, Brugman MH, Chambers SM, Shaw CA, Pike-Overzet K, de Ridder D, Staal FJ, von Keudell G, Cornils K, Nattamai KJ, Modlich U, Wagemaker G, Goodell MA, Fehse B, Baum C. Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways. Blood. 2007 Mar 1; 109(5):1897-907. PMID: 17119121; PMCID: PMC1801061.
    83. Dumble M, Moore L, Chambers SM, Geiger H, Van Zant G, Goodell MA, Donehower LA. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood. 2007 Feb 15; 109(4):1736-42. PMID: 17032926; PMCID: PMC1794064.
    84. Ramos CA, Bowman TA, Boles NC, Merchant AA, Zheng Y, Parra I, Fuqua SA, Shaw CA, Goodell MA. Evidence for diversity in transcriptional profiles of single hematopoietic stem cells. PLoS Genet. 2006 Sep 29; 2(9):e159. PMID: 17009876; PMCID: PMC1584276.
    85. Civin CI, Gewirtz AM, Goodell MA, Hawley RG, Murphy MJ. Editorial retraction. Stem Cells. 2006 Apr; 24(4):804. PMID: 16582451.
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    86. Lin KK, Goodell MA. Purification of hematopoietic stem cells using the side population. Methods Enzymol. 2006; 420:255-64. PMID: 17161700.
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    87. Bowman TV, McCooey AJ, Merchant AA, Ramos CA, Fonseca P, Poindexter A, Bradfute SB, Oliveira DM, Green R, Zheng Y, Jackson KA, Chambers SM, McKinney-Freeman SL, Norwood KG, Darlington G, Gunaratne PH, Steffen D, Goodell MA. Differential mRNA processing in hematopoietic stem cells. Stem Cells. 2006 Mar; 24(3):662-70. PMID: 16373690.
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    88. Goodell MA. Stem cell identification and sorting using the Hoechst 33342 side population (SP). Curr Protoc Cytom. 2005 Nov; Chapter 9:Unit9.18. PMID: 18770827.
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    89. Camargo FD, Chambers SM, Drew E, McNagny KM, Goodell MA. Hematopoietic stem cells do not engraft with absolute efficiencies. Blood. 2006 Jan 15; 107(2):501-7. PMID: 16204316; PMCID: PMC1895609.
    90. Bradfute SB, Graubert TA, Goodell MA. Roles of Sca-1 in hematopoietic stem/progenitor cell function. Exp Hematol. 2005 Jul; 33(7):836-43. PMID: 15963860.
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    91. Hirschmann-Jax C, Foster AE, Wulf GG, Goodell MA, Brenner MK. A distinct "side population" of cells in human tumor cells: implications for tumor biology and therapy. Cell Cycle. 2005 Feb; 4(2):203-5. PMID: 15655356.
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    92. Vieyra DS, Jackson KA, Goodell MA. Plasticity and tissue regenerative potential of bone marrow-derived cells. Stem Cell Rev. 2005; 1(1):65-9. PMID: 17132877.
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    93. Civin CI, Gewirtz AM, Hawley RG, Goodell MA. Advancing the fast-paced field of stem cell research: stem cells increases from 6 to 10 issues in its 23rd year of publication. Stem Cells. 2005; 23(1):1-2. PMID: 15625117.
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    94. Goodell MA, McKinney-Freeman S, Camargo FD. Isolation and characterization of side population cells. Methods Mol Biol. 2005; 290:343-52. PMID: 15361673.
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    95. Venezia TA, Merchant AA, Ramos CA, Whitehouse NL, Young AS, Shaw CA, Goodell MA. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2004 Oct; 2(10):e301. PMID: 15459755; PMCID: PMC520599.
    96. Hirschmann-Jax C, Foster AE, Wulf GG, Nuchtern JG, Jax TW, Gobel U, Goodell MA, Brenner MK. A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14228-33. PMID: 15381773; PMCID: PMC521140.
    97. McKinney-Freeman S, Goodell MA. Circulating hematopoietic stem cells do not efficiently home to bone marrow during homeostasis. Exp Hematol. 2004 Sep; 32(9):868-76. PMID: 15345289.
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    98. Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H. Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage. Biochemistry. 2004 May 11; 43(18):5352-9. PMID: 15122901.
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    99. Camargo FD, Finegold M, Goodell MA. Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. J Clin Invest. 2004 May; 113(9):1266-70. PMID: 15124017; PMCID: PMC398434.
    100. Snyder EY, Daley GQ, Goodell M. Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system. J Neurosci Res. 2004 Apr 15; 76(2):157-68. PMID: 15048913.
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    101. Norwood K, Wang RY, Hirschmann-Jax C, Andreeff M, Brenner MK, Goodell MA, Wulf GG. An in vivo propagated human acute myeloid leukemia expressing ABCA3. Leuk Res. 2004 Mar; 28(3):295-9. PMID: 14687625.
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    102. Camargo FD, Chambers SM, Goodell MA. Stem cell plasticity: from transdifferentiation to macrophage fusion. Cell Prolif. 2004 Feb; 37(1):55-65. PMID: 14871237.
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    103. Jackson KA, Snyder DS, Goodell MA. Skeletal muscle fiber-specific green autofluorescence: potential for stem cell engraftment artifacts. Stem Cells. 2004; 22(2):180-7. PMID: 14990857.
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    104. Olmsted-Davis EA, Gugala Z, Camargo F, Gannon FH, Jackson K, Kienstra KA, Shine HD, Lindsey RW, Hirschi KK, Goodell MA, Brenner MK, Davis AR. Primitive adult hematopoietic stem cells can function as osteoblast precursors. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15877-82. PMID: 14673088; PMCID: PMC307661.
    105. Camargo FD, Green R, Capetanaki Y, Jackson KA, Goodell MA, Capetenaki Y. Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates. Nat Med. 2003 Dec; 9(12):1520-7. PMID: 14625546.
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    106. Welm B, Behbod F, Goodell MA, Rosen JM. Isolation and characterization of functional mammary gland stem cells. Cell Prolif. 2003 Oct; 36 Suppl 1:17-32. PMID: 14521513; PMCID: PMC3496772.
    107. McKinney-Freeman SL, Majka SM, Jackson KA, Norwood K, Hirschi KK, Goodell MA. Altered phenotype and reduced function of muscle-derived hematopoietic stem cells. Exp Hematol. 2003 Sep; 31(9):806-14. PMID: 12962727.
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    108. Oliveira DM, Goodell MA. Transient RNA interference in hematopoietic progenitors with functional consequences. Genesis. 2003 Aug; 36(4):203-8. PMID: 12929091.
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    109. Nadin BM, Goodell MA, Hirschi KK. Phenotype and hematopoietic potential of side population cells throughout embryonic development. Blood. 2003 Oct 1; 102(7):2436-43. PMID: 12805065.
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    110. Brenner MK, Wulf GG, Rill DR, Luo KL, Goodell MA, Mei Z, Kuehnle I, Brown MP, Pule M, Heslop HE, Krance RA. Complement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man. Ann N Y Acad Sci. 2003 May; 996:80-8. PMID: 12799286.
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    111. Wulf GG, Luo KL, Jackson KA, Brenner MK, Goodell MA. Cells of the hepatic side population contribute to liver regeneration and can be replenished with bone marrow stem cells. Haematologica. 2003 Apr; 88(4):368-78. PMID: 12681963.
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    112. Bradfute SB, Goodell MA. Adenoviral transduction of mouse hematopoietic stem cells. Mol Ther. 2003 Mar; 7(3):334-40. PMID: 12668129.
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    113. Ramos CA, Venezia TA, Camargo FA, Goodell MA. Techniques for the study of adult stem cells: be fruitful and multiply. Biotechniques. 2003 Mar; 34(3):572-8, 580-4, 586-91. PMID: 12661162.
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    114. Daley GQ, Goodell MA, Snyder EY. Realistic prospects for stem cell therapeutics. Hematology Am Soc Hematol Educ Program. 2003; 398-418. PMID: 14633792.
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    115. Majka SM, Jackson KA, Kienstra KA, Majesky MW, Goodell MA, Hirschi KK. Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration. J Clin Invest. 2003 Jan; 111(1):71-9. PMID: 12511590; PMCID: PMC151835.
    116. Ramos CA, Zheng Y, Colombowala I, Goodell MA. Tracing the origin of non-hematopoietic cells using CD45 PCR restriction fragment length polymorphisms. Biotechniques. 2003 Jan; 34(1):160-2. PMID: 12545553.
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    117. Wulf GG, Luo KL, Goodell MA, Brenner MK. Anti-CD45-mediated cytoreduction to facilitate allogeneic stem cell transplantation. Blood. 2003 Mar 15; 101(6):2434-9. PMID: 12433683.
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    118. Castro RF, Jackson KA, Goodell MA, Robertson CS, Liu H, Shine HD. Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science. 2002 Aug 23; 297(5585):1299. PMID: 12193778.
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    119. Kuehnle I, Goodell MA. The therapeutic potential of stem cells from adults. BMJ. 2002 Aug 17; 325(7360):372-6. PMID: 12183311; PMCID: PMC1123887.
    120. Heinz M, Huang CA, Emery DW, Giovino MA, LeGuern A, Kurilla-Mahon B, Theodore P, Arn JS, Sykes M, Mulligan R, Down JD, Sachs DH, Goodell MA. Use of CD9 expression to enrich for porcine hematopoietic progenitors. Exp Hematol. 2002 Jul; 30(7):809-15. PMID: 12135680.
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    121. Hirschi KK, Goodell MA. Hematopoietic, vascular and cardiac fates of bone marrow-derived stem cells. Gene Ther. 2002 May; 9(10):648-52. PMID: 12032711.
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    122. Welm BE, Tepera SB, Venezia T, Graubert TA, Rosen JM, Goodell MA. Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. Dev Biol. 2002 May 1; 245(1):42-56. PMID: 11969254.
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    123. McKinney-Freeman SL, Jackson KA, Camargo FD, Ferrari G, Mavilio F, Goodell MA. Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proc Natl Acad Sci U S A. 2002 Feb 5; 99(3):1341-6. PMID: 11830662; PMCID: PMC122192.
    124. Goodell MA. Multipotential stem cells and 'side population' cells. Cytotherapy. 2002; 4(6):507-8. PMID: 12568983.
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    125. Jackson KA, Majka SM, Wulf GG, Goodell MA. Stem cells: a minireview. J Cell Biochem Suppl. 2002; 38:1-6. PMID: 12046843.
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    126. Goodell MA. Stem cells: is there a future in plastics? Curr Opin Cell Biol. 2001 Dec; 13(6):662-5. PMID: 11698180.
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    127. Wulf GG, Jackson KA, Goodell MA. Somatic stem cell plasticity: current evidence and emerging concepts. Exp Hematol. 2001 Dec; 29(12):1361-70. PMID: 11750094.
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    128. Hirschi K, Goodell M. Common origins of blood and blood vessels in adults? Differentiation. 2001 Oct; 68(4-5):186-92. PMID: 11776471.
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    129. Wulf GG, Wang RY, Kuehnle I, Weidner D, Marini F, Brenner MK, Andreeff M, Goodell MA. A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia. Blood. 2001 Aug 15; 98(4):1166-73. PMID: 11493466.
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    130. Jackson KA, Majka SM, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK, Goodell MA. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest. 2001 Jun; 107(11):1395-402. PMID: 11390421; PMCID: PMC209322.
    131. Goodell MA, Jackson KA, Majka SM, Mi T, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK. Stem cell plasticity in muscle and bone marrow. Ann N Y Acad Sci. 2001 Jun; 938:208-18; discussion 218-20. PMID: 11458510.
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    132. Storms RW, Goodell MA, Fisher A, Mulligan RC, Smith C. Hoechst dye efflux reveals a novel CD7(+)CD34(-) lymphoid progenitor in human umbilical cord blood. Blood. 2000 Sep 15; 96(6):2125-33. PMID: 10979957.
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    133. Jackson KA, Mi T, Goodell MA. Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc Natl Acad Sci U S A. 1999 Dec 7; 96(25):14482-6. PMID: 10588731; PMCID: PMC24462.
    134. Goodell MA. Introduction: Focus on hematology. CD34(+) or CD34(-): does it really matter? Blood. 1999 Oct 15; 94(8):2545-7. PMID: 10515855.
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    135. Goodell MA, Rosenzweig M, Kim H, Marks DF, DeMaria M, Paradis G, Grupp SA, Sieff CA, Mulligan RC, Johnson RP. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med. 1997 Dec; 3(12):1337-45. PMID: 9396603.
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    136. Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med. 1996 Apr 1; 183(4):1797-806. PMID: 8666936; PMCID: PMC2192511.
    137. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA. Effects of an Rb mutation in the mouse. Nature. 1992 Sep 24; 359(6393):295-300. PMID: 1406933.
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    138. Tudor M, Lobocka M, Goodell M, Pettitt J, O'Hare K. The pogo transposable element family of Drosophila melanogaster. Mol Gen Genet. 1992 Mar; 232(1):126-34. PMID: 1313144.
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