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DONALD PATRICK MCDONNELL

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
AddressOne Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tang X, Ding CK, Wu J, Sjol J, Wardell S, Spasojevic I, George D, McDonnell DP, Hsu DS, Chang JT, Chi JT. Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling. Oncogene. 2017 Jun 12. PMID: 28604749.
      View in: PubMed
    2. Norris JD, Ellison SJ, Baker JG, Stagg DB, Wardell SE, Park S, Alley HM, Baldi RM, Yllanes A, Andreano KJ, Stice JP, Lawrence SA, Eisner JR, Price DK, Moore WR, Figg WD, McDonnell DP. Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer. J Clin Invest. 2017 Jun 01; 127(6):2326-2338. PMID: 28463227.
      View in: PubMed
    3. Stice JP, Wardell SE, Norris JD, Yllanes AP, Alley HM, Haney VO, White HS, Safi R, Winter PS, Cocce KJ, Kishton RJ, Lawrence SA, Strum JC, McDonnell DP. CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC. Mol Cancer Res. 2017 Feb 16. PMID: 28209757.
      View in: PubMed
    4. Alfaqih MA, Nelson ER, Liu W, Safi R, Jasper JS, Macias E, Geradts J, Thompson JW, Dubois LG, Freeman MR, Chang CY, Chi JT, McDonnell DP, Freedland SJ. CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. Cancer Res. 2017 Jan 27. PMID: 28130224.
      View in: PubMed
    5. Nelson ER, Li S, Kennedy M, Payne S, Kilibarda K, Groth J, Bowie M, Parilla-Castellar E, de Ridder G, Marcom PK, Lyes M, Peterson BL, Cook M, Pizzo SV, McDonnell DP, Bachelder RE. Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface. Oncotarget. 2016 Dec 20; 7(51):84030-84042. PMID: 27768598.
      View in: PubMed
    6. Anderson GR, Wardell SE, Cakir M, Crawford L, Leeds JC, Nussbaum DP, Shankar PS, Soderquist RS, Stein EM, Tingley JP, Winter PS, Zieser-Misenheimer EK, Alley HM, Yllanes A, Haney V, Blackwell KL, McCall SJ, McDonnell DP, Wood KC. PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation. Sci Transl Med. 2016 Dec 14; 8(369):369ra175. PMID: 27974663.
      View in: PubMed
    7. Alexander PB, Chen R, Gong C, Yuan L, Jasper JS, Ding Y, Markowitz GJ, Yang P, Xu X, McDonnell DP, Song E, Wang XF. Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer. J Biol Chem. 2017 Jan 13; 292(2):748-759. PMID: 27903634.
      View in: PubMed
    8. Tang X, Ding CK, Wu J, Sjol J, Wardell S, Spasojevic I, George D, McDonnell DP, Hsu DS, Chang JT, Chi JT. Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling. Oncogene. 2016 Nov 21. PMID: 27869167.
      View in: PubMed
    9. Pollock JA, Wardell SE, Parent AA, Stagg DB, Ellison SJ, Alley HM, Chao CA, Lawrence SA, Stice JP, Spasojevic I, Baker JG, Kim SH, McDonnell DP, Katzenellenbogen JA, Norris JD. Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer. Nat Chem Biol. 2016 Oct; 12(10):795-801. PMID: 27501397.
      View in: PubMed
    10. Xu X, Zhang Y, Jasper J, Lykken E, Alexander PB, Markowitz GJ, McDonnell DP, Li QJ, Wang XF. MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer. Oncotarget. 2016 Apr 12; 7(15):20381-94. PMID: 26967387.
      View in: PubMed
    11. Park S, Chang CY, Safi R, Liu X, Baldi R, Jasper JS, Anderson GR, Liu T, Rathmell JC, Dewhirst MW, Wood KC, Locasale JW, McDonnell DP. ERR?-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. Cell Rep. 2016 Apr 12; 15(2):323-35. PMID: 27050525; PMCID: PMC4833658.
    12. Blessing AM, Ganesan S, Rajapakshe K, Ying Sung Y, Reddy Bollu L, Shi Y, Cheung E, Coarfa C, Chang JT, McDonnell DP, Frigo DE. Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. Mol Endocrinol. 2015 Oct; 29(10):1426-39. PMID: 26305679.
      View in: PubMed
    13. Wardell SE, Nelson ER, Chao CA, Alley HM, McDonnell DP. Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader. Endocr Relat Cancer. 2015 Oct; 22(5):713-24. PMID: 26162914.
      View in: PubMed
    14. Gustafson JL, Neklesa TK, Cox CS, Roth AG, Buckley DL, Tae HS, Sundberg TB, Stagg DB, Hines J, McDonnell DP, Norris JD, Crews CM. Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging. Angew Chem Int Ed Engl. 2015 Aug 10; 54(33):9659-62. PMID: 26083457.
      View in: PubMed
    15. Lontay B, Bodoor K, Sipos A, Weitzel DH, Loiselle D, Safi R, Zheng D, Devente J, Hickner RC, McDonnell DP, Ribar T, Haystead TA. Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice. J Biol Chem. 2015 Jul 17; 290(29):17985-98. PMID: 26048986.
      View in: PubMed
    16. McDonnell DP, Wardell SE, Norris JD. Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer. J Med Chem. 2015 Jun 25; 58(12):4883-7. PMID: 26039356.
      View in: PubMed
    17. Allensworth JL, Evans MK, Bertucci F, Aldrich AJ, Festa RA, Finetti P, Ueno NT, Safi R, McDonnell DP, Thiele DJ, Van Laere S, Devi GR. Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer. Mol Oncol. 2015 Jun; 9(6):1155-68. PMID: 25769405; PMCID: PMC4493866.
    18. Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, Flaherty KT, Wargo JA, McDonnell DP, Sabatini DM, Wood KC. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23; 7(357):ra121. PMID: 25538079; PMCID: PMC4353587.
    19. Nelson ER, Chang CY, McDonnell DP. Cholesterol and breast cancer pathophysiology. Trends Endocrinol Metab. 2014 Dec; 25(12):649-55. PMID: 25458418; PMCID: PMC4268141.
    20. McDonnell DP, Chang CY, Nelson ER. The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer. Climacteric. 2014 Dec; 17 Suppl 2:60-5. PMID: 25320023; PMCID: PMC4332512.
    21. Safi R, Nelson ER, Chitneni SK, Franz KJ, George DJ, Zalutsky MR, McDonnell DP. Copper signaling axis as a target for prostate cancer therapeutics. Cancer Res. 2014 Oct 15; 74(20):5819-31. PMID: 25320179; PMCID: PMC4203427.
    22. Choudhary M, Kazmin D, Hu P, Thomas RS, McDonnell DP, Malek G. Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways. J Pathol. 2015 Jan; 235(1):101-12. PMID: 25186463; PMCID: PMC4277859.
    23. Gustafsson JA, Katzenellenbogen B, Jameson JL, Roth J, Melmed S, McDonnell D, Wartofsky L, Crowley WF, Griz LH, Becker C, Moore DD, Drucker D, Singh N, O'Malley B. Endocrine Society 2014 Laureate Awards. Horm Cancer. 2014 Oct; 5(5):339-55. PMID: 25091407.
      View in: PubMed
    24. Wright TM, Wardell SE, Jasper JS, Stice JP, Safi R, Nelson ER, McDonnell DP. Delineation of a FOXA1/ER?/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer. Mol Cancer Res. 2014 Dec; 12(12):1829-39. PMID: 25100862; PMCID: PMC4272635.
    25. Wardell SE, Nelson ER, McDonnell DP. From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs). Steroids. 2014 Nov; 90:30-8. PMID: 25084324; PMCID: PMC4192009.
    26. McDonnell DP, Park S, Goulet MT, Jasper J, Wardell SE, Chang CY, Norris JD, Guyton JR, Nelson ER. Obesity, cholesterol metabolism, and breast cancer pathogenesis. Cancer Res. 2014 Sep 15; 74(18):4976-82. PMID: 25060521; PMCID: PMC4167494.
    27. Yang J, Fuller PJ, Morgan J, Shibata H, McDonnell DP, Clyne CD, Young MJ. Use of phage display to identify novel mineralocorticoid receptor-interacting proteins. Mol Endocrinol. 2014 Sep; 28(9):1571-84. PMID: 25000480.
      View in: PubMed
    28. Scholtz EL, Krishnan S, Ball BA, Corbin CJ, Moeller BC, Stanley SD, McDowell KJ, Hughes AL, McDonnell DP, Conley AJ. Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5?-dihydroprogesterone. Proc Natl Acad Sci U S A. 2014 Mar 4; 111(9):3365-70. PMID: 24550466; PMCID: PMC3948269.
    29. Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ, Pillai RV, Sullivan PM, Sondhi V, Umetani M, Geradts J, McDonnell DP. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science. 2013 Nov 29; 342(6162):1094-8. PMID: 24288332; PMCID: PMC3899689.
    30. Hu P, Herrmann R, Bednar A, Saloupis P, Dwyer MA, Yang P, Qi X, Thomas RS, Jaffe GJ, Boulton ME, McDonnell DP, Malek G. Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):E4069-78. PMID: 24106308; PMCID: PMC3808645.
    31. Wardell SE, Nelson ER, Chao CA, McDonnell DP. Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease. Clin Cancer Res. 2013 May 1; 19(9):2420-31. PMID: 23536434; PMCID: PMC3643989.
    32. Shatnawi A, Norris JD, Chaveroux C, Jasper JS, Sherk AB, McDonnell DP, Giguère V. ELF3 is a repressor of androgen receptor action in prostate cancer cells. Oncogene. 2014 Feb 13; 33(7):862-71. PMID: 23435425; PMCID: PMC4103030.
    33. Augello MA, Burd CJ, Birbe R, McNair C, Ertel A, Magee MS, Frigo DE, Wilder-Romans K, Shilkrut M, Han S, Jernigan DL, Dean JL, Fatatis A, McDonnell DP, Visakorpi T, Feng FY, Knudsen KE. Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. J Clin Invest. 2013 Jan; 123(1):493-508. PMID: 23257359; PMCID: PMC3533295.
    34. Shi Y, Han JJ, Tennakoon JB, Mehta FF, Merchant FA, Burns AR, Howe MK, McDonnell DP, Frigo DE. Androgens promote prostate cancer cell growth through induction of autophagy. Mol Endocrinol. 2013 Feb; 27(2):280-95. PMID: 23250485; PMCID: PMC3683804.
    35. Nelson ER, Wardell SE, McDonnell DP. The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis. Bone. 2013 Mar; 53(1):42-50. PMID: 23168292; PMCID: PMC3552054.
    36. Chang CY, McDonnell DP. Molecular pathways: the metabolic regulator estrogen-related receptor ? as a therapeutic target in cancer. Clin Cancer Res. 2012 Nov 15; 18(22):6089-95. PMID: 23019305; PMCID: PMC3500439.
    37. Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG. Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ER?-dependent and -independent manners. ACS Chem Biol. 2012 Jul 20; 7(7):1221-31. PMID: 22533360; PMCID: PMC3582702.
    38. Wardell SE, Kazmin D, McDonnell DP. Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes. Mol Endocrinol. 2012 Jul; 26(7):1235-48. PMID: 22570330; PMCID: PMC3385791.
    39. Malek G, Dwyer M, McDonnell D. Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD. Adv Exp Med Biol. 2012; 723:51-9. PMID: 22183315.
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    40. Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, Rathmell JC. Estrogen-related receptor-? is a metabolic regulator of effector T-cell activation and differentiation. Proc Natl Acad Sci U S A. 2011 Nov 8; 108(45):18348-53. PMID: 22042850; PMCID: PMC3215012.
    41. Chang CY, Kazmin D, Jasper JS, Kunder R, Zuercher WJ, McDonnell DP. The metabolic regulator ERR?, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. Cancer Cell. 2011 Oct 18; 20(4):500-10. PMID: 22014575; PMCID: PMC3199323.
    42. Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP. The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology. 2011 Dec; 152(12):4691-705. PMID: 21933863; PMCID: PMC3230052.
    43. Bodoor K, Lontay B, Safi R, Weitzel DH, Loiselle D, Wei Z, Lengyel S, McDonnell DP, Haystead TA. Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy. J Biol Chem. 2011 Sep 9; 286(36):31839-51. PMID: 21771785; PMCID: PMC3173130.
    44. Wardell SE, Marks JR, McDonnell DP. The turnover of estrogen receptor ? by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy. Biochem Pharmacol. 2011 Jul 15; 82(2):122-30. PMID: 21501600; PMCID: PMC3109090.
    45. Dwyer MA, Kazmin D, Hu P, McDonnell DP, Malek G. Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration. Mol Endocrinol. 2011 Feb; 25(2):360-72. PMID: 21239617; PMCID: PMC3386542.
    46. McDonnell DP, Wardell SE. The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer. Curr Opin Pharmacol. 2010 Dec; 10(6):620-8. PMID: 20926342; PMCID: PMC2981619.
    47. Yang J, Chang CY, Safi R, Morgan J, McDonnell DP, Fuller PJ, Clyne CD, Young MJ. Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display. Mol Endocrinol. 2011 Jan; 25(1):32-43. PMID: 21106883.
      View in: PubMed
    48. Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR, McDonnell DP. CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. Cancer Res. 2011 Jan 15; 71(2):528-37. PMID: 21098087; PMCID: PMC3074523.
    49. Kobayashi S, Stice JP, Kazmin D, Wittmann BM, Kimbrel EA, Edwards DP, Chang CY, McDonnell DP. Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer. Mol Endocrinol. 2010 Dec; 24(12):2292-302. PMID: 20980435; PMCID: PMC2999472.
    50. Dwyer MA, Joseph JD, Wade HE, Eaton ML, Kunder RS, Kazmin D, Chang CY, McDonnell DP. WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. Cancer Res. 2010 Nov 15; 70(22):9298-308. PMID: 20870744; PMCID: PMC2982857.
    51. Orr CR, Montie HL, Liu Y, Bolzoni E, Jenkins SC, Wilson EM, Joseph JD, McDonnell DP, Merry DE. An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. J Biol Chem. 2010 Nov 12; 285(46):35567-77. PMID: 20826791; PMCID: PMC2975181.
    52. DuSell CD, Nelson ER, Wang X, Abdo J, Mödder UI, Umetani M, Gesty-Palmer D, Javitt NB, Khosla S, McDonnell DP. The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. Endocrinology. 2010 Aug; 151(8):3675-85. PMID: 20501668; PMCID: PMC2940523.
    53. Muramoto GG, Russell JL, Safi R, Salter AB, Himburg HA, Daher P, Meadows SK, Doan P, Storms RW, Chao NJ, McDonnell DP, Chute JP. Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. Stem Cells. 2010 Mar 31; 28(3):523-34. PMID: 20054864; PMCID: PMC3909217.
    54. Wade HE, Kobayashi S, Eaton ML, Jansen MS, Lobenhofer EK, Lupien M, Geistlinger TR, Zhu W, Nevins JR, Brown M, Otteson DC, McDonnell DP. Multimodal regulation of E2F1 gene expression by progestins. Mol Cell Biol. 2010 Apr; 30(8):1866-77. PMID: 20123965; PMCID: PMC2849472.
    55. Hall JM, Barhoover MA, Kazmin D, McDonnell DP, Greenlee WF, Thomas RS. Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation. Mol Endocrinol. 2010 Feb; 24(2):359-69. PMID: 20032195; PMCID: PMC2817602.
    56. Zhou XE, Suino-Powell K, Ludidi PL, McDonnell DP, Xu HE. Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs. Protein Expr Purif. 2010 May; 71(1):21-7. PMID: 19995608; PMCID: PMC2830347.
    57. Alaynick WA, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Chang CY, McDonnell DP, Evans RM, Billin AN. ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. Mol Endocrinol. 2010 Feb; 24(2):299-309. PMID: 19965931; PMCID: PMC2817599.
    58. Chute JP, Ross JR, McDonnell DP. Minireview: Nuclear receptors, hematopoiesis, and stem cells. Mol Endocrinol. 2010 Jan; 24(1):1-10. PMID: 19934345; PMCID: PMC2802897.
    59. Norris JD, Chang CY, Wittmann BM, Kunder RS, Cui H, Fan D, Joseph JD, McDonnell DP. The homeodomain protein HOXB13 regulates the cellular response to androgens. Mol Cell. 2009 Nov 13; 36(3):405-16. PMID: 19917249; PMCID: PMC2788777.
    60. DuSell CD, Nelson ER, Wittmann BM, Fretz JA, Kazmin D, Thomas RS, Pike JW, McDonnell DP. Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan; 24(1):33-46. PMID: 19901195; PMCID: PMC2802893.
    61. Joseph JD, Wittmann BM, Dwyer MA, Cui H, Dye DA, McDonnell DP, Norris JD. Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12178-83. PMID: 19574450; PMCID: PMC2715477.
    62. Frigo DE, Sherk AB, Wittmann BM, Norris JD, Wang Q, Joseph JD, Toner AP, Brown M, McDonnell DP. Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro. Mol Endocrinol. 2009 Sep; 23(9):1385-96. PMID: 19460858; PMCID: PMC2737557.
    63. Norris JD, Joseph JD, Sherk AB, Juzumiene D, Turnbull PS, Rafferty SW, Cui H, Anderson E, Fan D, Dye DA, Deng X, Kazmin D, Chang CY, Willson TM, McDonnell DP. Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands. Chem Biol. 2009 Apr 24; 16(4):452-60. PMID: 19389631; PMCID: PMC2673463.
    64. Grasfeder LL, Gaillard S, Hammes SR, Ilkayeva O, Newgard CB, Hochberg RB, Dwyer MA, Chang CY, McDonnell DP. Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. Mol Endocrinol. 2009 Aug; 23(8):1171-82. PMID: 19389810; PMCID: PMC2718748.
    65. Stein RA, Gaillard S, McDonnell DP. Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells. J Steroid Biochem Mol Biol. 2009 Mar; 114(1-2):106-12. PMID: 19429439; PMCID: PMC2680788.
    66. Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, McDonnell DP. Glucose metabolism as a target of histone deacetylase inhibitors. Mol Endocrinol. 2009 Mar; 23(3):388-401. PMID: 19106193; PMCID: PMC2654518.
    67. Safi R, Muramoto GG, Salter AB, Meadows S, Himburg H, Russell L, Daher P, Doan P, Leibowitz MD, Chao NJ, McDonnell DP, Chute JP. Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. Mol Endocrinol. 2009 Feb; 23(2):188-201. PMID: 19106195; PMCID: PMC2646618.
    68. Stein RA, Chang CY, Kazmin DA, Way J, Schroeder T, Wergin M, Dewhirst MW, McDonnell DP. Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. Cancer Res. 2008 Nov 1; 68(21):8805-12. PMID: 18974123; PMCID: PMC2633645.
    69. Sherk AB, Frigo DE, Schnackenberg CG, Bray JD, Laping NJ, Trizna W, Hammond M, Patterson JR, Thompson SK, Kazmin D, Norris JD, McDonnell DP. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res. 2008 Sep 15; 68(18):7475-83. PMID: 18794135; PMCID: PMC2562281.
    70. DuSell CD, McDonnell DP. 27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling. Trends Pharmacol Sci. 2008 Oct; 29(10):510-4. PMID: 18722677; PMCID: PMC2702440.
    71. Frigo DE, McDonnell DP. Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation. Mol Cancer Ther. 2008 Mar; 7(3):659-69. PMID: 18347151.
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    72. Hyatt SM, Lockamy EL, Stein RA, McDonnell DP, Miller AB, Orband-Miller LA, Willson TM, Zuercher WJ. On the intractability of estrogen-related receptor alpha as a target for activation by small molecules. J Med Chem. 2007 Dec 27; 50(26):6722-4. PMID: 18052088; PMCID: PMC2556064.
    73. Wittmann BM, Sherk A, McDonnell DP. Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators. Cancer Res. 2007 Oct 1; 67(19):9549-60. PMID: 17909066.
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    74. DuSell CD, Umetani M, Shaul PW, Mangelsdorf DJ, McDonnell DP. 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol Endocrinol. 2008 Jan; 22(1):65-77. PMID: 17872378; PMCID: PMC2194632.
    75. Mettu NB, Stanley TB, Dwyer MA, Jansen MS, Allen JE, Hall JM, McDonnell DP. The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors. Mol Endocrinol. 2007 Oct; 21(10):2361-77. PMID: 17595321.
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    76. Hall JM, McDonnell DP. The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages. Mol Endocrinol. 2007 Aug; 21(8):1756-68. PMID: 17488971.
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    77. Zella LA, Chang CY, McDonnell DP, Pike JW. The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs. Arch Biochem Biophys. 2007 Apr 15; 460(2):206-12. PMID: 17254542; PMCID: PMC1924797.
    78. Gaillard S, Grasfeder LL, Haeffele CL, Lobenhofer EK, Chu TM, Wolfinger R, Kazmin D, Koves TR, Muoio DM, Chang CY, McDonnell DP. Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. Mol Cell. 2006 Dec 8; 24(5):797-803. PMID: 17157261.
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    79. Stein RA, McDonnell DP. Estrogen-related receptor alpha as a therapeutic target in cancer. Endocr Relat Cancer. 2006 Dec; 13 Suppl 1:S25-32. PMID: 17259555.
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    80. Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol Rev. 2006 Dec; 58(4):782-97. PMID: 17132855.
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    81. McDonnell DP. Mechanism-based discovery as an approach to identify the next generation of estrogen receptor modulators. FASEB J. 2006 Dec; 20(14):2432-4. PMID: 17142791.
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    82. Zhang Y, Ma K, Sadana P, Chowdhury F, Gaillard S, Wang F, McDonnell DP, Unterman TG, Elam MB, Park EA. Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. J Biol Chem. 2006 Dec 29; 281(52):39897-906. PMID: 17079227.
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    83. Gaillard S, Dwyer MA, McDonnell DP. Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions. Mol Endocrinol. 2007 Jan; 21(1):62-76. PMID: 17053040.
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    84. Chute JP, Muramoto GG, Whitesides J, Colvin M, Safi R, Chao NJ, McDonnell DP. Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. Proc Natl Acad Sci U S A. 2006 Aug 1; 103(31):11707-12. PMID: 16857736; PMCID: PMC1544234.
    85. Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Human PXR forms a tryptophan zipper-mediated homodimer. Biochemistry. 2006 Jul 18; 45(28):8579-89. PMID: 16834332; PMCID: PMC2515391.
    86. Kazmin D, Prytkova T, Cook CE, Wolfinger R, Chu TM, Beratan D, Norris JD, Chang CY, McDonnell DP. Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. Mol Endocrinol. 2006 Jun; 20(6):1201-17. PMID: 16574741.
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    87. Safi R, Kovacic A, Gaillard S, Murata Y, Simpson ER, McDonnell DP, Clyne CD. Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. Cancer Res. 2005 Dec 15; 65(24):11762-70. PMID: 16357189.
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    88. Hall JM, McDonnell DP. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Mol Interv. 2005 Dec; 5(6):343-57. PMID: 16394250.
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    89. Chao EY, Collins JL, Gaillard S, Miller AB, Wang L, Orband-Miller LA, Nolte RT, McDonnell DP, Willson TM, Zuercher WJ. Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg Med Chem Lett. 2006 Feb 15; 16(4):821-4. PMID: 16307879.
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    90. Solomon IH, Hager JM, Safi R, McDonnell DP, Redinbo MR, Ortlund EA. Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. J Mol Biol. 2005 Dec 16; 354(5):1091-102. PMID: 16289203.
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    91. Juzumiene D, Chang CY, Fan D, Hartney T, Norris JD, McDonnell DP. Single-step purification of full-length human androgen receptor. Nucl Recept Signal. 2005; 3:e001. PMID: 16604169; PMCID: PMC1402216.
    92. Chang CY, Abdo J, Hartney T, McDonnell DP. Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display. Mol Endocrinol. 2005 Oct; 19(10):2478-90. PMID: 16051662.
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    93. Wu YL, Yang X, Ren Z, McDonnell DP, Norris JD, Willson TM, Greene GL. Structural basis for an unexpected mode of SERM-mediated ER antagonism. Mol Cell. 2005 May 13; 18(4):413-24. PMID: 15893725.
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    94. Zuercher WJ, Gaillard S, Orband-Miller LA, Chao EY, Shearer BG, Jones DG, Miller AB, Collins JL, McDonnell DP, Willson TM. Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J Med Chem. 2005 May 5; 48(9):3107-9. PMID: 15857113.
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    95. Chang CY, McDonnell DP. Androgen receptor-cofactor interactions as targets for new drug discovery. Trends Pharmacol Sci. 2005 May; 26(5):225-8. PMID: 15860367.
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    96. Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat Struct Mol Biol. 2005 Apr; 12(4):357-63. PMID: 15723037.
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    97. Shaffer PL, McDonnell DP, Gewirth DT. Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor. Biochemistry. 2005 Feb 22; 44(7):2678-85. PMID: 15709781.
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    98. McDonnell DP. The molecular pharmacology of estrogen receptor modulators: implications for the treatment of breast cancer. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 2):871s-7s. PMID: 15701880.
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    99. McDonnell DP. The molecular determinants of estrogen receptor pharmacology. Maturitas. 2004 Aug 30; 48 Suppl 1:S7-12. PMID: 15337242.
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    100. Shao W, Keeton EK, McDonnell DP, Brown M. Coactivator AIB1 links estrogen receptor transcriptional activity and stability. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11599-604. PMID: 15289619; PMCID: PMC511007.
    101. Turgeon JL, McDonnell DP, Martin KA, Wise PM. Hormone therapy: physiological complexity belies therapeutic simplicity. Science. 2004 May 28; 304(5675):1269-73. PMID: 15166356.
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    102. Jansen MS, Nagel SC, Miranda PJ, Lobenhofer EK, Afshari CA, McDonnell DP. Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proc Natl Acad Sci U S A. 2004 May 4; 101(18):7199-204. PMID: 15103026; PMCID: PMC406489.
    103. Kurebayashi S, Nakajima T, Kim SC, Chang CY, McDonnell DP, Renaud JP, Jetten AM. Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. Biochem Biophys Res Commun. 2004 Mar 19; 315(4):919-27. PMID: 14985100.
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    104. Tirado OM, Selva DM, Toràn N, Suárez-Quian CA, Jansen M, McDonnell DP, Reventós J, Munell F. Increased expression of estrogen receptor beta in pachytene spermatocytes after short-term methoxyacetic acid administration. J Androl. 2004 Jan-Feb; 25(1):84-94. PMID: 14662790.
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    105. Sathya G, Chang CY, Kazmin D, Cook CE, McDonnell DP. Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion. Cancer Res. 2003 Nov 15; 63(22):8029-36. PMID: 14633736.
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    106. McDonnell DP. Mining the complexities of the estrogen signaling pathways for novel therapeutics. Endocrinology. 2003 Oct; 144(10):4237-40. PMID: 14500558.
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    107. Rincavage HL, McDonnell DP, Kuhn CM. Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells. Endocrinology. 2003 Jul; 144(7):2829-35. PMID: 12810537.
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    108. Pike JW, Pathrose P, Barmina O, Chang CY, McDonnell DP, Yamamoto H, Shevde NK. Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription. J Cell Biochem. 2003 Feb 1; 88(2):252-8. PMID: 12520523.
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    109. Chang CY, Norris JD, Jansen M, Huang HJ, McDonnell DP. Application of random peptide phage display to the study of nuclear hormone receptors. Methods Enzymol. 2003; 364:118-42. PMID: 14631842.
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    110. Pathrose P, Barmina O, Chang CY, McDonnell DP, Shevde NK, Pike JW. Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors. J Bone Miner Res. 2002 Dec; 17(12):2196-205. PMID: 12469913.
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    111. Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, McDonnell D. Problems for risk assessment of endocrine-active estrogenic compounds. Environ Health Perspect. 2002 Dec; 110 Suppl 6:925-9. PMID: 12634121; PMCID: PMC1241274.
    112. Sathya G, Jansen MS, Nagel SC, Cook CE, McDonnell DP. Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins. Endocrinology. 2002 Aug; 143(8):3071-82. PMID: 12130573.
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    113. Huang HJ, Norris JD, McDonnell DP. Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists. Mol Endocrinol. 2002 Aug; 16(8):1778-92. PMID: 12145334.
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    114. Sathya G, Jansen MS, Nagel SC, Cook CE, McDonnell DP. Identification and Characterization of Novel Estrogen Receptor-?-Sparing Antiprogestins. Endocrinology. 2002 Aug 01; 143(8):3071-3082. PMID: 28201467.
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    115. McDonnell DP, Wijayaratne A, Chang CY, Norris JD. Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. Am J Cardiol. 2002 Jul 3; 90(1A):35F-43F. PMID: 12106639.
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    116. Li X, Kimbrel EA, Kenan DJ, McDonnell DP. Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation. Mol Endocrinol. 2002 Jul; 16(7):1482-91. PMID: 12089344.
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    117. Li X, McDonnell DP. The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. Mol Cell Biol. 2002 Jun; 22(11):3663-73. PMID: 11997503; PMCID: PMC133817.
    118. McDonnell DP, Norris JD. Connections and regulation of the human estrogen receptor. Science. 2002 May 31; 296(5573):1642-4. PMID: 12040178.
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    119. Herrington DM, Howard TD, Brosnihan KB, McDonnell DP, Li X, Hawkins GA, Reboussin DM, Xu J, Zheng SL, Meyers DA, Bleecker ER. Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein. Circulation. 2002 Apr 23; 105(16):1879-82. PMID: 11997270.
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    120. Chang CY, McDonnell DP. Evaluation of ligand-dependent changes in AR structure using peptide probes. Mol Endocrinol. 2002 Apr; 16(4):647-60. PMID: 11923463.
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    121. Hall JM, McDonnell DP, Korach KS. Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. Mol Endocrinol. 2002 Mar; 16(3):469-86. PMID: 11875105.
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    122. Weatherman RV, Chang CY, Clegg NJ, Carroll DC, Day RN, Baxter JD, McDonnell DP, Scanlan TS, Schaufele F. Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer. Mol Endocrinol. 2002 Mar; 16(3):487-96. PMID: 11875107.
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    123. Norris JD, Fan D, Sherk A, McDonnell DP. A negative coregulator for the human ER. Mol Endocrinol. 2002 Mar; 16(3):459-68. PMID: 11875103.
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    124. McDonnell DP, Connor CE, Wijayaratne A, Chang CY, Norris JD. Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators. Recent Prog Horm Res. 2002; 57:295-316. PMID: 12017549.
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    125. Chang CY, Walther PJ, McDonnell DP. Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer. Cancer Res. 2001 Dec 15; 61(24):8712-7. PMID: 11751389.
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    126. McDonnell DP, Chang CY, Norris JD. Capitalizing on the complexities of estrogen receptor pharmacology in the quest for the perfect SERM. Ann N Y Acad Sci. 2001 Dec; 949:16-35. PMID: 11795348.
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    127. Nagel SC, Hagelbarger JL, McDonnell DP. Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. Endocrinology. 2001 Nov; 142(11):4721-8. PMID: 11606437.
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    128. Wijayaratne AL, McDonnell DP. The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J Biol Chem. 2001 Sep 21; 276(38):35684-92. PMID: 11473106.
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    129. Hamilton MH, Tcherepanova I, Huibregtse JM, McDonnell DP. Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. J Biol Chem. 2001 Jul 13; 276(28):26324-31. PMID: 11342538.
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    130. Connor CE, Norris JD, Broadwater G, Willson TM, Gottardis MM, Dewhirst MW, McDonnell DP. Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. Cancer Res. 2001 Apr 1; 61(7):2917-22. PMID: 11306468.
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    131. Norris JD, Chang C, McDonnell DP. Estrogen receptor-cofactor interactions as targets for novel drug discovery. Ernst Schering Res Found Workshop. 2001; (34):181-201. PMID: 11394045.
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    132. Schaufele F, Chang CY, Liu W, Baxter JD, Nordeen SK, Wan Y, Day RN, McDonnell DP. Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. Mol Endocrinol. 2000 Dec; 14(12):2024-39. PMID: 11117532.
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    133. Hall JM, Chang CY, McDonnell DP. Development of peptide antagonists that target estrogen receptor beta-coactivator interactions. Mol Endocrinol. 2000 Dec; 14(12):2010-23. PMID: 11117531.
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    134. McDonnell DP, Chang CY, Norris JD. Development of peptide antagonists that target estrogen receptor-cofactor interactions. J Steroid Biochem Mol Biol. 2000 Nov 30; 74(5):327-35. PMID: 11162941.
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    135. Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D, Safe S. Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Mol Pharmacol. 2000 Oct; 58(4):852-8. PMID: 10999957.
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    136. Tcherepanova I, Puigserver P, Norris JD, Spiegelman BM, McDonnell DP. Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. J Biol Chem. 2000 May 26; 275(21):16302-8. PMID: 10748020.
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    137. Giangrande PH, Kimbrel EA, Edwards DP, McDonnell DP. The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol Cell Biol. 2000 May; 20(9):3102-15. PMID: 10757795; PMCID: PMC85605.
    138. McDonnell DP. Selective estrogen receptor modulators (SERMs): A first step in the development of perfect hormone replacement therapy regimen. J Soc Gynecol Investig. 2000 Jan-Feb; 7(1 Suppl):S10-5. PMID: 10732322.
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    139. Wijayaratne AL, Nagel SC, Paige LA, Christensen DJ, Norris JD, Fowlkes DM, McDonnell DP. Comparative analyses of mechanistic differences among antiestrogens. Endocrinology. 1999 Dec; 140(12):5828-40. PMID: 10579349.
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    140. Gaido KW, Leonard LS, Maness SC, Hall JM, McDonnell DP, Saville B, Safe S. Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. Endocrinology. 1999 Dec; 140(12):5746-53. PMID: 10579340.
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    141. Hall JM, McDonnell DP. The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology. 1999 Dec; 140(12):5566-78. PMID: 10579320.
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    142. Chang Cy, Norris JD, Grøn H, Paige LA, Hamilton PT, Kenan DJ, Fowlkes D, McDonnell DP. Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta. Mol Cell Biol. 1999 Dec; 19(12):8226-39. PMID: 10567548; PMCID: PMC84907.
    143. Gaido KW, Leonard LS, Maness SC, Hall JM, McDonnell DP, Saville B, Safe S. Differential Interaction of the Methoxychlor Metabolite 2,2-Bis-(p-Hydroxyphenyl)-1,1,1-Trichloroethane with Estrogen Receptors ? and ?1. Endocrinology. 1999 Dec 01; 140(12):5746-5753. PMID: 28200584.
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    144. Wijayaratne AL, Nagel SC, Paige LA, Christensen DJ, Norris JD, Fowlkes DM, McDonnell DP. Comparative Analyses of Mechanistic Differences Among Antiestrogens1. Endocrinology. 1999 Dec 01; 140(12):5828-5840. PMID: 28200824.
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    145. Hall JM, McDonnell DP. The Estrogen Receptor ?-Isoform (ER?) of the Human Estrogen Receptor Modulates ER? Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens1. Endocrinology. 1999 Dec 01; 140(12):5566-5578. PMID: 28200448.
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    146. Beaudenon SL, Huacani MR, Wang G, McDonnell DP, Huibregtse JM. Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. Mol Cell Biol. 1999 Oct; 19(10):6972-9. PMID: 10490634; PMCID: PMC84692.
    147. Nishida J, McDonnell D, McCuskey MK, Ekataksin W, McCuskey RS. In vivo and electron microscopic observations of the responses of the hepatic sinusoid to interleukin-1. Bull Tokyo Dent Coll. 1999 Aug; 40(3):139-48. PMID: 10825814.
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    148. Norris JD, Paige LA, Christensen DJ, Chang CY, Huacani MR, Fan D, Hamilton PT, Fowlkes DM, McDonnell DP. Peptide antagonists of the human estrogen receptor. Science. 1999 Jul 30; 285(5428):744-6. PMID: 10426998.
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    149. Tetel MJ, Giangrande PH, Leonhardt SA, McDonnell DP, Edwards DP. Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. Mol Endocrinol. 1999 Jun; 13(6):910-24. PMID: 10379890.
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    150. Improta-Brears T, Whorton AR, Codazzi F, York JD, Meyer T, McDonnell DP. Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. Proc Natl Acad Sci U S A. 1999 Apr 13; 96(8):4686-91. PMID: 10200323; PMCID: PMC16393.
    151. Paige LA, Christensen DJ, Grøn H, Norris JD, Gottlin EB, Padilla KM, Chang CY, Ballas LM, Hamilton PT, McDonnell DP, Fowlkes DM. Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3999-4004. PMID: 10097152; PMCID: PMC22409.
    152. Wagner BL, Pollio G, Giangrande P, Webster JC, Breslin M, Mais DE, Cook CE, Vedeckis WV, Cidlowski JA, McDonnell DP. The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: implications for the development of dissociated antiprogestins. Endocrinology. 1999 Mar; 140(3):1449-58. PMID: 10067874.
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    153. Wagner BL, Pollio G, Giangrande P, Webster JC, Breslin M, Mais DE, Cook CE, Vedeckis WV, Cidlowski JA, McDonnell DP. The Novel Progesterone Receptor Antagonists RTI 3021-012 and RTI3021-022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins. Endocrinology. 1999 Mar 01; 140(3):1449-1458. PMID: 28204331.
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    154. Giangrande PH, McDonnell DP. The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. Recent Prog Horm Res. 1999; 54:291-313; discussion 313-4. PMID: 10548881.
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    155. Gould JC, Leonard LS, Maness SC, Wagner BL, Conner K, Zacharewski T, Safe S, McDonnell DP, Gaido KW. Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. Mol Cell Endocrinol. 1998 Jul 25; 142(1-2):203-14. PMID: 9783916.
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    156. Maness SC, McDonnell DP, Gaido KW. Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. Toxicol Appl Pharmacol. 1998 Jul; 151(1):135-42. PMID: 9705896.
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    157. Norris JD, Fan D, Stallcup MR, McDonnell DP. Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology. J Biol Chem. 1998 Mar 20; 273(12):6679-88. PMID: 9506965.
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    158. Wagner BL, Norris JD, Knotts TA, Weigel NL, McDonnell DP. The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor. Mol Cell Biol. 1998 Mar; 18(3):1369-78. PMID: 9488452; PMCID: PMC108850.
    159. McDonnell DP. Definition of the molecular mechanism of action of tissue-selective oestrogen-receptor modulators. Biochem Soc Trans. 1998 Feb; 26(1):54-60. PMID: 10909757.
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    160. Giangrande PH, Pollio G, McDonnell DP. Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor. J Biol Chem. 1997 Dec 26; 272(52):32889-900. PMID: 9407067.
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    161. Ramamoorthy K, Vyhlidal C, Wang F, Chen I, Safe S, McDonnell DP, Leonard LS, Gaido KW. Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. Toxicol Appl Pharmacol. 1997 Nov; 147(1):93-100. PMID: 9356311.
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    162. Willson TM, Norris JD, Wagner BL, Asplin I, Baer P, Brown HR, Jones SA, Henke B, Sauls H, Wolfe S, Morris DC, McDonnell DP. Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone. Endocrinology. 1997 Sep; 138(9):3901-11. PMID: 9275080.
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    163. Coldham NG, Dave M, Sivapathasundaram S, McDonnell DP, Connor C, Sauer MJ. Evaluation of a recombinant yeast cell estrogen screening assay. Environ Health Perspect. 1997 Jul; 105(7):734-42. PMID: 9294720; PMCID: PMC1470103.
    164. Norris JD, Fan D, Kerner SA, McDonnell DP. Identification of a third autonomous activation domain within the human estrogen receptor. Mol Endocrinol. 1997 Jun; 11(6):747-54. PMID: 9171238.
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    165. Ramamoorthy K, Wang F, Chen IC, Norris JD, McDonnell DP, Leonard LS, Gaido KW, Bocchinfuso WP, Korach KS, Safe S. Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Endocrinology. 1997 Apr; 138(4):1520-7. PMID: 9075711.
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    166. Gaido KW, Leonard LS, Lovell S, Gould JC, Babaï D, Portier CJ, McDonnell DP. Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. Toxicol Appl Pharmacol. 1997 Mar; 143(1):205-12. PMID: 9073609.
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    167. Marks JR, Huper G, Vaughn JP, Davis PL, Norris J, McDonnell DP, Wiseman RW, Futreal PA, Iglehart JD. BRCA1 expression is not directly responsive to estrogen. Oncogene. 1997 Jan 9; 14(1):115-21. PMID: 9010238.
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    168. McCuskey RS, Nishida J, McDonnell D, Williams C, Koldovsky O. Effect of milk-borne epidermal growth factor on the hepatic microcirculation and Kupffer cell function in suckling rats. Biol Neonate. 1997; 71(3):202-6. PMID: 9096901.
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    169. McDonnell DP, Norris JD. Analysis of the molecular pharmacology of estrogen receptor agonists and antagonists provides insights into the mechanism of action of estrogen in bone. Osteoporos Int. 1997; 7 Suppl 1:S29-34. PMID: 9205643.
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    170. Fan JD, Wagner BL, McDonnell DP. Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity. Mol Endocrinol. 1996 Dec; 10(12):1605-16. PMID: 8961270.
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    171. Wagner BL, Pollio G, Leonhardt S, Wani MC, Lee DY, Imhof MO, Edwards DP, Cook CE, McDonnell DP. 16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity. Proc Natl Acad Sci U S A. 1996 Aug 6; 93(16):8739-44. PMID: 8710941; PMCID: PMC38743.
    172. Imhof MO, McDonnell DP. Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. Mol Cell Biol. 1996 Jun; 16(6):2594-605. PMID: 8649367; PMCID: PMC231250.
    173. Vegeto E, Wagner BL, Imhof MO, McDonnell DP. The molecular pharmacology of ovarian steroid receptors. Vitam Horm. 1996; 52:99-128. PMID: 8909158.
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    174. Norris J, Fan D, Aleman C, Marks JR, Futreal PA, Wiseman RW, Iglehart JD, Deininger PL, McDonnell DP. Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers. J Biol Chem. 1995 Sep 29; 270(39):22777-82. PMID: 7559405.
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    175. McDonnell DP, Dana SL, Hoener PA, Lieberman BA, Imhof MO, Stein RB. Cellular mechanisms which distinguish between hormone- and antihormone-activated estrogen receptor. Ann N Y Acad Sci. 1995 Jun 12; 761:121-37. PMID: 7625716.
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    176. Clemm DL, Macy BL, Santiso-Mere D, McDonnell DP. Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor. J Steroid Biochem Mol Biol. 1995 Jun; 53(1-6):487-95. PMID: 7626499.
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    177. McDonnell DP, Clemm DL, Hermann T, Goldman ME, Pike JW. Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. Mol Endocrinol. 1995 Jun; 9(6):659-69. PMID: 8592512.
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    178. McDonnell DP. Unraveling the human progesterone receptor signal transduction pathway Insights into antiprogestin action. Trends Endocrinol Metab. 1995 May-Jun; 6(4):133-8. PMID: 18406695.
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    179. McCuskey RS, Nishida J, Eguchi H, McDonnell D, Baker GL, Ekataksin W, Krasovich MA, Rudi V, Seitz HK, Urbaschek B, et al. Role of endotoxin in the hepatic microvascular inflammatory response to ethanol. J Gastroenterol Hepatol. 1995; 10 Suppl 1:S18-23. PMID: 8589335.
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    180. Wen DX, Xu YF, Mais DE, Goldman ME, McDonnell DP. The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. Mol Cell Biol. 1994 Dec; 14(12):8356-64. PMID: 7969170; PMCID: PMC359374.
    181. Klein KO, Baron J, Colli MJ, McDonnell DP, Cutler GB. Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay. J Clin Invest. 1994 Dec; 94(6):2475-80. PMID: 7989605; PMCID: PMC330080.
    182. Mukherjee R, Jow L, Noonan D, McDonnell DP. Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J Steroid Biochem Mol Biol. 1994 Nov; 51(3-4):157-66. PMID: 7981125.
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    183. McDonnell DP, Clemm DL, Imhof MO. Definition of the cellular mechanisms which distinguish between hormone and antihormone activated steroid receptors. Semin Cancer Biol. 1994 Oct; 5(5):327-36. PMID: 7849261.
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    184. Tai PK, Albers MW, McDonnell DP, Chang H, Schreiber SL, Faber LE. Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. Biochemistry. 1994 Sep 6; 33(35):10666-71. PMID: 7521210.
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    185. Dana SL, Hoener PA, Wheeler DA, Lawrence CB, McDonnell DP. Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells. Mol Endocrinol. 1994 Sep; 8(9):1193-207. PMID: 7838152.
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    186. Crombie DL, Mukherjee R, McDonnell DP, Hayes JS, Wang MW. Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment. J Steroid Biochem Mol Biol. 1994 Jun; 49(2-3):123-9. PMID: 8031708.
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    187. McDonnell DP, Goldman ME. RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism. J Biol Chem. 1994 Apr 22; 269(16):11945-9. PMID: 8163495.
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    188. McDonnell DP, Shahbaz MM, Vegeto E, Goldman ME. The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity. J Steroid Biochem Mol Biol. 1994 Apr; 48(5-6):425-32. PMID: 8180103.
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    189. Tzukerman MT, Esty A, Santiso-Mere D, Danielian P, Parker MG, Stein RB, Pike JW, McDonnell DP. Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol Endocrinol. 1994 Jan; 8(1):21-30. PMID: 8152428.
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    190. McDonnell DP, Clevenger B, Dana S, Santiso-Mere D, Tzukerman MT, Gleeson MA. The mechanism of action of steroid hormones: a new twist to an old tale. J Clin Pharmacol. 1993 Dec; 33(12):1165-72. PMID: 8126251.
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    191. McDonnell DP, Vegeto E, Gleeson MA. Nuclear hormone receptors as targets for new drug discovery. Biotechnology (N Y). 1993 Nov; 11(11):1256-61. PMID: 7764187.
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    192. Andrews E, Jansen R, Crane AM, Cholin S, McDonnell D, Ledley FD. Expression of recombinant human methylmalonyl-CoA mutase: in primary mut fibroblasts and Saccharomyces cerevisiae. Biochem Med Metab Biol. 1993 Oct; 50(2):135-44. PMID: 7903149.
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    193. Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP. Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol. 1993 Oct; 7(10):1244-55. PMID: 8264658.
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    194. Poletti A, Conneely OM, McDonnell DP, Schrader WT, O'Malley BW, Weigel NL. Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites. Biochemistry. 1993 Sep 21; 32(37):9563-9. PMID: 8373763.
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    195. Santiso-Mere D, Sone T, Hilliard GM, Pike JW, McDonnell DP. Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems. Mol Endocrinol. 1993 Jul; 7(7):833-9. PMID: 8413308.
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    196. Nawaz Z, Stancel GM, McDonnell DP, Hyder SM. Creation of an active estrogen-responsive element by a single base change in the flanking sequence of a cellular oncogene: a possible mechanism for hormonal carcinogenesis? Mol Carcinog. 1993; 7(2):76-82. PMID: 8457291.
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    197. McDonnell DP, Vegeto E, O'Malley BW. Identification of a negative regulatory function for steroid receptors. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10563-7. PMID: 1438251; PMCID: PMC50381.
    198. Hyder SM, Stancel GM, Nawaz Z, McDonnell DP, Loose-Mitchell DS. Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene. J Biol Chem. 1992 Sep 5; 267(25):18047-54. PMID: 1517237.
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    199. Pham TA, Hwung YP, Santiso-Mere D, McDonnell DP, O'Malley BW. Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast. Mol Endocrinol. 1992 Jul; 6(7):1043-50. PMID: 1508220.
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    200. Wooge CH, Nilsson GM, Heierson A, McDonnell DP, Katzenellenbogen BS. Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells. Mol Endocrinol. 1992 Jun; 6(6):861-9. PMID: 1495491.
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    201. Vegeto E, Allan GF, Schrader WT, Tsai MJ, McDonnell DP, O'Malley BW. The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell. 1992 May 15; 69(4):703-13. PMID: 1586949.
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    202. Poletti A, Weigel NL, McDonnell DP, Schrader WT, O'Malley BW, Conneely OM. A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae. Gene. 1992 May 1; 114(1):51-8. PMID: 1316867.
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    203. Pham TA, McDonnell DP, Tsai MJ, O'Malley BW. Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes. Biochemistry. 1992 Feb 11; 31(5):1570-8. PMID: 1737013.
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    204. Fuqua SA, Fitzgerald SD, Allred DC, Elledge RM, Nawaz Z, McDonnell DP, O'Malley BW, Greene GL, McGuire WL. Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors. Cancer Res. 1992 Jan 15; 52(2):483-6. PMID: 1728420.
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    205. Nawaz Z, Tsai MJ, McDonnell DP, O'Malley BW. Identification of novel steroid-response elements. Gene Expr. 1992; 2(1):39-47. PMID: 1617301.
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    206. Pham TA, Hwung YP, McDonnell DP, O'Malley BW. Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo. J Biol Chem. 1991 Sep 25; 266(27):18179-87. PMID: 1917950.
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    207. McDonnell DP, Nawaz Z, O'Malley BW. In situ distinction between steroid receptor binding and transactivation at a target gene. Mol Cell Biol. 1991 Sep; 11(9):4350-5. PMID: 1875926; PMCID: PMC361296.
    208. McDonnell DP, Nawaz Z, Densmore C, Weigel NL, Pham TA, Clark JH, O'Malley BW. High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae. J Steroid Biochem Mol Biol. 1991 Sep; 39(3):291-7. PMID: 1911419.
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    209. Pham TA, Elliston JF, Nawaz Z, McDonnell DP, Tsai MJ, O'Malley BW. Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):3125-9. PMID: 2014231; PMCID: PMC51398.
    210. Fuqua SA, Fitzgerald SD, Chamness GC, Tandon AK, McDonnell DP, Nawaz Z, O'Malley BW, McGuire WL. Variant human breast tumor estrogen receptor with constitutive transcriptional activity. Cancer Res. 1991 Jan 1; 51(1):105-9. PMID: 1988075.
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    211. Sone T, McDonnell DP, O'Malley BW, Pike JW. Expression of human vitamin D receptor in Saccharomyces cerevisiae. Purification, properties, and generation of polyclonal antibodies. J Biol Chem. 1990 Dec 15; 265(35):21997-2003. PMID: 2174892.
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    212. Liao J, Ozono K, Sone T, McDonnell DP, Pike JW. Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A. 1990 Dec; 87(24):9751-5. PMID: 2175914; PMCID: PMC55251.
    213. Power RF, Conneely OM, McDonnell DP, Clark JH, Butt TR, Schrader WT, O'Malley BW. High level expression of a truncated chicken progesterone receptor in Escherichia coli. J Biol Chem. 1990 Jan 25; 265(3):1419-24. PMID: 2153132.
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    214. Mak P, McDonnell DP, Weigel NL, Schrader WT, O'Malley BW. Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae). J Biol Chem. 1989 Dec 25; 264(36):21613-8. PMID: 2689442.
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    215. McDonnell DP, Pike JW, Drutz DJ, Butt TR, O'Malley BW. Reconstitution of the vitamin D-responsive osteocalcin transcription unit in Saccharomyces cerevisiae. Mol Cell Biol. 1989 Aug; 9(8):3517-23. PMID: 2552296; PMCID: PMC362399.
    216. McDonnell DP, Scott RA, Kerner SA, O'Malley BW, Pike JW. Functional domains of the human vitamin D3 receptor regulate osteocalcin gene expression. Mol Endocrinol. 1989 Apr; 3(4):635-44. PMID: 2542779.
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    217. Hughes M, Malloy P, Kieback D, McDonnell D, Feldman D, Pike JW, O'Malley B. Human vitamin D receptor mutations: identification of molecular defects in hypocalcemic vitamin D resistant rickets. Adv Exp Med Biol. 1989; 255:491-503. PMID: 2618873.
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    218. Baker AR, McDonnell DP, Hughes M, Crisp TM, Mangelsdorf DJ, Haussler MR, Pike JW, Shine J, O'Malley BW. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci U S A. 1988 May; 85(10):3294-8. PMID: 2835767; PMCID: PMC280195.
    219. McDonnell DP, Pike JW, O'Malley BW. The vitamin D receptor: a primitive steroid receptor related to thyroid hormone receptor. J Steroid Biochem. 1988; 30(1-6):41-6. PMID: 2838696.
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    220. Haussler MR, Mangelsdorf DJ, Komm BS, Terpening CM, Yamaoka K, Allegretto EA, Baker AR, Shine J, McDonnell DP, Hughes M, et al. Molecular biology of the vitamin D hormone. Recent Prog Horm Res. 1988; 44:263-305. PMID: 2851156.
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    221. Mangelsdorf DJ, Komm BS, McDonnell DP, Pike JW, Haussler MR. Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone. Biochemistry. 1987 Dec 15; 26(25):8332-8. PMID: 3442659.
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    222. McDonnell DP, Mangelsdorf DJ, Pike JW, Haussler MR, O'Malley BW. Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science. 1987 Mar 6; 235(4793):1214-7. PMID: 3029866.
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    223. Maxwell BL, McDonnell DP, Conneely OM, Schulz TZ, Greene GL, O'Malley BW. Structural organization and regulation of the chicken estrogen receptor. Mol Endocrinol. 1987 Jan; 1(1):25-35. PMID: 2901032.
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