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C KENT OSBORNE

TitleDirector
InstitutionBaylor College of Medicine
DepartmentDuncan Cancer Center
DivisionCancer Center
AddressOne Baylor Plaza 335A
Houston TX 77030
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    Other Positions
    TitleDistinguished Service Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Hematology & Oncology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentBreast Center
    DivisionBreast Cancer Center

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDuncan Cancer Center
    DivisionCancer Center


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rimawi MF, Schiff R, Osborne CK. Targeting HER2 for the treatment of breast cancer. Annu Rev Med. 2015; 66:111-28. PMID: 25587647.
      View in: PubMed
    2. Morrison G, Fu X, Shea M, Nanda S, Giuliano M, Wang T, Klinowska T, Osborne CK, Rimawi MF, Schiff R. Therapeutic potential of the dual EGFR/HER2 inhibitor AZD8931 in circumventing endocrine resistance. Breast Cancer Res Treat. 2014 Apr; 144(2):263-72. PMID: 24554387; PMCID: PMC4030601.
    3. Fan Y, Ge N, Wang X, Sun W, Mao R, Bu W, Creighton CJ, Zheng P, Vasudevan S, An L, Yang J, Zhao YJ, Zhang H, Li XN, Rao PH, Leung E, Lu YJ, Gray JW, Schiff R, Hilsenbeck SG, Osborne CK, Yang J, Zhang H. Amplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells. J Pathol. 2014 Jan; 232(1):75-86. PMID: 24122835; PMCID: PMC3966110.
    4. Haricharan S, Dong J, Hein S, Reddy JP, Du Z, Toneff M, Holloway K, Hilsenbeck SG, Huang S, Atkinson R, Woodward W, Jindal S, Borges VF, Gutierrez C, Zhang H, Schedin PJ, Osborne CK, Tweardy DJ, Li Y. Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy. Elife. 2013; 2:e00996. PMID: 24381245; PMCID: PMC3874103.
    5. Zhang XH, Giuliano M, Trivedi MV, Schiff R, Osborne CK. Metastasis dormancy in estrogen receptor-positive breast cancer. Clin Cancer Res. 2013 Dec 1; 19(23):6389-97. PMID: 24298069; PMCID: PMC3878717.
    6. Fu X, Osborne CK, Schiff R. Biology and therapeutic potential of PI3K signaling in ER+/HER2-negative breast cancer. Breast. 2013 Aug; 22 Suppl 2:S12-8. PMID: 24011769; PMCID: PMC3808116.
    7. Parma J, Pavlick A, Schiff R, Osborne CK, Chang JC, Rimawi M, Trivedi MV. Development of acneiform rash does not predict response to lapatinib treatment in patients with breast cancer. Pharmacotherapy. 2013 Oct; 33(10):1126-9. PMID: 23744830.
      View in: PubMed
    8. Rimawi MF, Mayer IA, Forero A, Nanda R, Goetz MP, Rodriguez AA, Pavlick AC, Wang T, Hilsenbeck SG, Gutierrez C, Schiff R, Osborne CK, Chang JC. Multicenter phase II study of neoadjuvant lapatinib and trastuzumab with hormonal therapy and without chemotherapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer: TBCRC 006. J Clin Oncol. 2013 May 10; 31(14):1726-31. PMID: 23569315; PMCID: PMC3641695.
    9. Lippman M, Osborne CK. Circulating tumor DNA--ready for prime time? N Engl J Med. 2013 Mar 28; 368(13):1249-50. PMID: 23484798.
      View in: PubMed
    10. Li, M.M., Chang, F., Liu, L. , Fang, E., Li, Y., Carmack, C.E., Osborne, C.K. . AGBT. Identification of Clinically Actionable Mutations Using Next Generation Sequencing Technologies – Perspectives from Clinical Diagnostics. 2013.
    11. Contreras, A., Herrera, S., Mayer, I., Forero, A., Nanda, R., Goetz, M., Chang, J., Pavlick, A.C., Fuqua, S.A.W., Gutierrez, C., Li, M.M., Osborne, C.K., Schiff, R., Rimawi, M.F. . SABCS. PIK3CA mutations and / or low PTEN predict resistance to combined anti-HER2 therapy with lapatinib and trastuzumab but without chemotherapy in TBCRC006, a neoadjuvant trial of HER2-positive patients. 2013.
    12. Morrison, G., Fu, X., Shea M., Mitchell, T., Giuliano, M., Osborne, C.K., Klinowska T., Rimawi, M.F., Schiff, R. . SABCS. Therapeutic potential of the dual HER1/2 inhibitor AZD8931 in circumventing endocrine resistance. 2013.
    13. Malorni L, Shetty PB, De Angelis C, Hilsenbeck S, Rimawi MF, Elledge R, Osborne CK, De Placido S, Arpino G. Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up. Breast Cancer Res Treat. 2012 Dec; 136(3):795-804. PMID: 23124476; PMCID: PMC3513514.
    14. Healy NA, Heneghan HM, Miller N, Osborne CK, Schiff R, Kerin MJ. Systemic mirnas as potential biomarkers for malignancy. Int J Cancer. 2012 Nov 15; 131(10):2215-22. PMID: 22618667.
      View in: PubMed
    15. Brouckaert O, Paridaens R, Floris G, Rakha E, Osborne K, Neven P. A critical review why assessment of steroid hormone receptors in breast cancer should be quantitative. Ann Oncol. 2013 Jan; 24(1):47-53. PMID: 22847811.
      View in: PubMed
    16. Chen AC, Migliaccio I, Rimawi M, Lopez-Tarruella S, Creighton CJ, Massarweh S, Huang C, Wang YC, Batra SK, Gutierrez MC, Osborne CK, Schiff R. Upregulation of mucin4 in ER-positive/HER2-overexpressing breast cancer xenografts with acquired resistance to endocrine and HER2-targeted therapies. Breast Cancer Res Treat. 2012 Jul; 134(2):583-93. PMID: 22644656; PMCID: PMC3408244.
    17. Rimawi MF, Osborne CK. Breast Cancer: Blocking both driver and escape pathways improves outcomes. Nat Rev Clin Oncol. 2012 Mar; 9(3):133-4. PMID: 22330685.
      View in: PubMed
    18. Giuliano, M., Trivedi, M.V., Christiny, P., Zhang, X., Mao, S., Contreras, A., Lewis, M.T., Rimawi, M.F., Osborne, C.K, Schiff, R. . AACR. Circulating tumor cells as a novel model to test efficacy of individualized therapy in breast cancer. 2012.
    19. Kessler, J.D., Kahle, K.T., Sun, T., Meerbrey, K.L., Schlabach, M.R., Schmitt, E., Skinner, S.O., Xu, Q., Li, M.Z., Hartman, Z.C., Rao, M., Yu, P., Dominguez-Vidana, R., Liang, A.C., Solimini, N.L., Bernardi, R.J., Yu, B., Hsu, T., Golding, I., Luo, J., Osborne, C.K., Creighton, C., Hilsenbeck, S.G., Schiff, R., Shaw, C.A., Elledge, S.J., Westbrook, T.F. . AACR. A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. 2012.
    20. Rimawi, M.F., Aleixo, S., Rozas, A.A., de Matos Neto, J.N., Caleffi, M., Vinholes, J., Figueira, A., Souza, S.C., Reiriz, A.B., Arantes, H., Uttenreuther-Fischer, M. . J Clin Oncol. A neoadjuvant, randomized, open-label Phase II trial of afatinib (A) vs. Trastuzumab (T) vs. Lapatinib (L) in patients (pts) with locally advanced HER2-positive breast cancer (BC). 2012; (30).
    21. Li, M., Wen, Y., Fang, E., Li, Y., Chen, P., Douglas, G., Carmack, C., Osborne, K. . American Society of Human Genetics. Next Generation Sequencing and Chromosomal Microarray Analysis Provide Novel Insight into the Genomic Landscape of Metastatic Breast Cancer. 2012.
    22. Giuliano, M., Wang, Y-C., Gutierrez, C., Rimawi, M.F., Chang J.C., Wang T., Hilsenbeck, S.G., Chamness, G.C., Osborne, C.K., Schiff, R. . SABCS. Parallel upregulation of Bcl2 and estrogen receptor (ER) expression in HER2+ breast cancer patients treated with neoadjuvant lapatinib. 2012.
    23. Fu, X., Kumar, V., Shea, M., Biswal, N.C., Nanda, S., Chayanam, S., Mitchell, T., Meerbrey, K. L., Joshi, A., Westbrook, T.F., Mills, G.B., Creighton, C.J., Hilsenbeck, S.G., Osborne, C.K., Schiff, R. . SABCS. Overcoming endocrine therapy resistance related to PTEN loss by strategic combinations with mTOR, AKT, or MEK inhibitors. 2012.
    24. Shou, J., Chew, S.A., Fu, X., Kumar, V., Mitsiades, N., Osborne, C.K., Schiff, R. SABCS. The PKC inhibitor PKC412 antagonizes breast cancer cell growth and enhances tamoxifen sensitivity. 2012.
    25. Margossian, A., Gutierrez, C., May, M., Saadjian, H., Ohanessian, R., Bacigalupo, S., Baravalle, S., Margossian, J., Osborne, C.K., Scheurer, M. . SABCS. Creation of a “state-of-the-art” Breast Cancer Data and Biobank in Argentina. 2012.
    26. Yadav, P., Bhat, R., Chayanam, S., Christiny, P., Nanda, S., Hu, Huizhong, Creighton, C., Osborne, C.K., Schiff, R., Trivedi, M.V. . SABCS. Identification of novel G-protein coupled receptor targets in HER2-positive breast cancer. 2012.
    27. Hartmaier RJ, Richter AS, Gillihan RM, Sallit JZ, McGuire SE, Wang J, Lee AV, Osborne CK, O'Malley BW, Brown PH, Xu J, Skaar TC, Philips S, Rae JM, Azzouz F, Li L, Hayden J, Henry NL, Nguyen AT, Stearns V, Hayes DF, Flockhart DA, Oesterreich S. A SNP in steroid receptor coactivator-1 disrupts a GSK3? phosphorylation site and is associated with altered tamoxifen response in bone. Mol Endocrinol. 2012 Feb; 26(2):220-7. PMID: 22174377; PMCID: PMC3275159.
    28. Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science. 2012 Jan 20; 335(6066):348-53. PMID: 22157079; PMCID: PMC4059214.
    29. Osborne CK, Evens A. Select interviews from the 2011 San Antonio Breast Cancer Symposium (SABCS) and American Society of Hematology (ASH) Annual Meeting. Oncology (Williston Park). 2011 Dec; 25(14):1422-4, 1426. PMID: 22329194.
      View in: PubMed
    30. Arteaga CL, Sliwkowski MX, Osborne CK, Perez EA, Puglisi F, Gianni L. Treatment of HER2-positive breast cancer: current status and future perspectives. Nat Rev Clin Oncol. 2012 Jan; 9(1):16-32. PMID: 22124364.
      View in: PubMed
    31. Wang YC, Morrison G, Gillihan R, Guo J, Ward RM, Fu X, Botero MF, Healy NA, Hilsenbeck SG, Phillips GL, Chamness GC, Rimawi MF, Osborne CK, Schiff R. Different mechanisms for resistance to trastuzumab versus lapatinib in HER2-positive breast cancers--role of estrogen receptor and HER2 reactivation. Breast Cancer Res. 2011; 13(6):R121. PMID: 22123186; PMCID: PMC3326563.
    32. Giuliano M, Schifp R, Osborne CK, Trivedi MV. Biological mechanisms and clinical implications of endocrine resistance in breast cancer. Breast. 2011 Oct; 20 Suppl 3:S42-9. PMID: 22015292.
      View in: PubMed
    33. Huang C, Park CC, Hilsenbeck SG, Ward R, Rimawi MF, Wang YC, Shou J, Bissell MJ, Osborne CK, Schiff R. ?1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. Breast Cancer Res. 2011; 13(4):R84. PMID: 21884573; PMCID: PMC3236347.
    34. Glück S, Arteaga CL, Osborne CK. Optimizing chemotherapy-free survival for the ER/HER2-positive metastatic breast cancer patient. Clin Cancer Res. 2011 Sep 1; 17(17):5559-61. PMID: 21764887.
      View in: PubMed
    35. Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 2011 Mar 4; 144(5):703-18. PMID: 21376233.
      View in: PubMed
    36. Osborne CK, Neven P, Dirix LY, Mackey JR, Robert J, Underhill C, Schiff R, Gutierrez C, Migliaccio I, Anagnostou VK, Rimm DL, Magill P, Sellers M. Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: a randomized phase II study. Clin Cancer Res. 2011 Mar 1; 17(5):1147-59. PMID: 21220480; PMCID: PMC3074404.
    37. Osborne CK, Schiff R. Mechanisms of endocrine resistance in breast cancer. Annu Rev Med. 2011; 62:233-47. PMID: 20887199; PMCID: PMC3656649.
    38. Fu, X., Shea, M., Biswal, N.C., Mitchell, T., Giuliano, M., Healy, N.A., Joshi, A., Westbrook, T., Hilsenbeck, S.G., Osborne, C.K., Schiff, R. . SABCS. Establishment and characterization of an endocrine resistance model in vitro and in vivo by inducible PTEN knockdown. 2011.
    39. Chang, J.C.N., Mayer, I.A., Forero-Torres, A., Nanda, R., Goetz, M.P., Rodriguez, A.A., Pavlick, A.C., Wang, T., Hilsenbeck, S.G., Gutierrez, C., Schiff, R., Osborne, C.K., Rimawi, M.F., on behalf of the Translational Breast Cancer Research Consortium (TBCRC); . TBCRC 006: A multicenter phase II study of neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2 overexpressing breast cancer. 2011.
    40. Covington, K.R., Gu, G., Tsimelzon, A., Hilsenbeck, S., Brown, P., Chang, J., Osborne, C.K., Xu, J., Medina, D., Mangelsdorf, D., Minna, J., Fuqua, S. . AACR. Identification of novel nuclear receptor targets in estrogen receptor negative breast cancer.Identification of novel nuclear receptor targets in estrogen receptor negative breast cancer. 2011.
    41. Jiralerspong, S., Wang, T., Rimawi, M.F., Nangia J.R., Schif R., Giordano, S.H., Pollak, M.N., Chenault, C.C., Osborne, C.K., Hilsenbeck, S.G. . Cancer Res. Obesity, adjuvant therapy and Survival outcomes in early stage breast cancer. 2011; 199s.
    42. Healy, N.A., Creighton, C.J., Fu, X., Tsimelzon, A., Hilesenbeck, S.G., Miller, N., Kerin, M.J., Osborne, C.K., Schiff, R. . . Cancer Res. Identification of miRNAs and their associated target genes involved in endocrine resistance in breast cancer. 2011; 343s.
    43. Morrison, G.D., Fu, X., Ithimakin, S., Rimawi, M.F., Wicha, M.S., Osborne, C.K., Schiff, R. . Cancer Res. Endocrine resistance: Mechanism, tumorigenic capacities and new therapeutic strategies. 2011; 422s.
    44. Fu, X., Shea, M., Biswal, N.C., Mitchell, T., Giuliano, M., Healy, N.A., Meerbrey, K.L., Joshi, A., Westbrook, T., Hilsenbeck, S.G., Osborne, C.K., Schiff, R. . Cancer Res. Establishment and characterization of an endocrine resistance model in vitro and in vivo by inducible PTEN knockdown. 2011; 423s.
    45. Malorni, L., Giuliano, M., Migliaccio, I., Wang, T., Creighton, C.J., Lupien, M., Hilsenbeck, S.G., Healy, N., Mazumdar, A., Trivedi, M.V., Jeselsohn, R., He, H.H., Fu, X., Gutierrez, C., Brown, M., Brown, P.H., Osborne, C.K., Schiff, R. . Cancer Res. AP-1 blockade potentiates the anti-tumor effect of endocrine treatment and reverts the resistant phenotype in hormone receptor-positive breast cancer. 2011; 429s.
    46. Giuliano, M. Christiny, P.I., Zhang, X., Mao, S., Contreras, A., Lewis, M.T., Rimawi, M.F., Osborne, C.K., Schiff, R., Trivedi, M.V. AACR. Identification of triple-negative primary breast cancer xenograft models with high numbers of circulating and disseminated tumor cells. 2011.
    47. Yao S, Barlow WE, Albain KS, Choi JY, Zhao H, Livingston RB, Davis W, Rae JM, Yeh IT, Hutchins LF, Ravdin PM, Martino S, Lyss AP, Osborne CK, Abeloff M, Hortobagyi GN, Hayes DF, Ambrosone CB. Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer. Clin Cancer Res. 2010 Dec 15; 16(24):6169-76. PMID: 21169260; PMCID: PMC3058716.
    48. Rimawi MF, Wiechmann LS, Wang YC, Huang C, Migliaccio I, Wu MF, Gutierrez C, Hilsenbeck SG, Arpino G, Massarweh S, Ward R, Soliz R, Osborne CK, Schiff R. Reduced dose and intermittent treatment with lapatinib and trastuzumab for potent blockade of the HER pathway in HER2/neu-overexpressing breast tumor xenografts. Clin Cancer Res. 2011 Mar 15; 17(6):1351-61. PMID: 21138857; PMCID: PMC3060302.
    49. Dave B, Migliaccio I, Gutierrez MC, Wu MF, Chamness GC, Wong H, Narasanna A, Chakrabarty A, Hilsenbeck SG, Huang J, Rimawi M, Schiff R, Arteaga C, Osborne CK, Chang JC. Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers. J Clin Oncol. 2011 Jan 10; 29(2):166-73. PMID: 21135276; PMCID: PMC3058274.
    50. LaCroix AZ, Powles T, Osborne CK, Wolter K, Thompson JR, Thompson DD, Allred DC, Armstrong R, Cummings SR, Eastell R, Ensrud KE, Goss P, Lee A, Neven P, Reid DM, Curto M, Vukicevic S. Breast cancer incidence in the randomized PEARL trial of lasofoxifene in postmenopausal osteoporotic women. J Natl Cancer Inst. 2010 Nov 17; 102(22):1706-15. PMID: 21051656.
      View in: PubMed
    51. Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab Med. 2010 Jul; 134(7):e48-72. PMID: 20586616.
      View in: PubMed
    52. Rodriguez AA, Makris A, Wu MF, Rimawi M, Froehlich A, Dave B, Hilsenbeck SG, Chamness GC, Lewis MT, Dobrolecki LE, Jain D, Sahoo S, Osborne CK, Chang JC. DNA repair signature is associated with anthracycline response in triple negative breast cancer patients. Breast Cancer Res Treat. 2010 Aug; 123(1):189-96. PMID: 20582464.
      View in: PubMed
    53. Creighton CJ, Fu X, Hennessy BT, Casa AJ, Zhang Y, Gonzalez-Angulo AM, Lluch A, Gray JW, Brown PH, Hilsenbeck SG, Osborne CK, Mills GB, Lee AV, Schiff R. Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer. Breast Cancer Res. 2010; 12(3):R40. PMID: 20569503; PMCID: PMC2917035.
    54. Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. Arch Pathol Lab Med. 2010 Jun; 134(6):907-22. PMID: 20524868; PMCID: PMC3073033.
    55. Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC. American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Clin Oncol. 2010 Jun 1; 28(16):2784-95. PMID: 20404251; PMCID: PMC2881855.
    56. Yao S, Barlow WE, Albain KS, Choi JY, Zhao H, Livingston RB, Davis W, Rae JM, Yeh IT, Hutchins LF, Ravdin PM, Martino S, Lyss AP, Osborne CK, Abeloff MD, Hortobagyi GN, Hayes DF, Ambrosone CB. Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer. Breast Cancer Res Treat. 2010 Nov; 124(2):433-9. PMID: 20309628; PMCID: PMC2968705.
    57. Rimawi MF, Shetty PB, Weiss HL, Schiff R, Osborne CK, Chamness GC, Elledge RM. Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes. Cancer. 2010 Mar 1; 116(5):1234-42. PMID: 20082448; PMCID: PMC2829330.
    58. Chen, A.C., Migliaccio, I., Gilcrease, M., Osborne, C.K., and Schiff R. SABCS 2010 (page 198S) P2-06-09. Cancer Res. Mucin4 is associated with the Loss of Estrogen-receptor alpha in Breast Cancer. 2010; 198s.
    59. Sun, T., Meerbrey, K.L., Kessler J., Botero, M., Migliaccio, I., Nguyen, D.X., Pavlova, N.N., Bernardi, R.J., Schmitt, E., Hilsenbeck, S.G., Creighton, C.J., Shaw, C.A., Gibbs, R., Wheeler, D., Osborne, C.K., Schiff, R., Elledge, S.J., Westbrook, T.F. . Cancer Res. Identification of a Novel Tumor Suppressor Network Reveals a Role for Proto-Oncogenic Receptor Tyrosine Kinase in Triple-Negative Breast Cancer. 2010; 24:95s.
    60. Oesterreich S., Hilsenbeck, S.G., Skaar, T., Hartmaier, R.J., Flockhart, D.A., Skora, M.J., Osborne, C.K., Rae, J.M. . Correlations between Genetic Variants in CYP2D6 and UGT2B7 and Survival in Breast Cancer Patients Treated with or without Tamoxifen: Results from a Large Cohort Study. 2010.
    61. Fu, X., Wang Y-C., Huang, C., Ward, R.M., Botero, M.F., Shea, M., Hilsenbeck, S.G., Osborne, C.K., Schiff, R. . Plasticity of the ER and HER2 Signaling Networks Results in Compensatory Escape Pathways Contributing to Treatment Resistance. 2010.
    62. Malorni, L., Giuliano, M., Migliaccio, I., Healy, N., Wang, T., Creighton, C.J., Lupien, M.,Hilsenbeck, S.G., Healy, N., Mazumdar, A.,Trivedi, M., Jeselsohn, R., He, H.H., Fu, X., Gutierrez C., Brown, M., Brown, P.H., Osborne, C.K., Schiff, R. . AP-1 blockade potentiates the anti-tumor effect of endocrine treatment and reverts the resistant phenotype in hormone receptor-positive breast cancer. 2010.
    63. Albain KS, Barlow WE, Shak S, Hortobagyi GN, Livingston RB, Yeh IT, Ravdin P, Bugarini R, Baehner FL, Davidson NE, Sledge GW, Winer EP, Hudis C, Ingle JN, Perez EA, Pritchard KI, Shepherd L, Gralow JR, Yoshizawa C, Allred DC, Osborne CK, Hayes DF. Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial. Lancet Oncol. 2010 Jan; 11(1):55-65. PMID: 20005174; PMCID: PMC3058239.
    64. Albain KS, Barlow WE, Ravdin PM, Farrar WB, Burton GV, Ketchel SJ, Cobau CD, Levine EG, Ingle JN, Pritchard KI, Lichter AS, Schneider DJ, Abeloff MD, Henderson IC, Muss HB, Green SJ, Lew D, Livingston RB, Martino S, Osborne CK. Adjuvant chemotherapy and timing of tamoxifen in postmenopausal patients with endocrine-responsive, node-positive breast cancer: a phase 3, open-label, randomised controlled trial. Lancet. 2009 Dec 19; 374(9707):2055-63. PMID: 20004966; PMCID: PMC3140679.
    65. Migliaccio I, Wu MF, Gutierrez C, Malorni L, Mohsin SK, Allred DC, Hilsenbeck SG, Osborne CK, Weiss H, Lee AV. Nuclear IRS-1 predicts tamoxifen response in patients with early breast cancer. Breast Cancer Res Treat. 2010 Oct; 123(3):651-60. PMID: 19924529; PMCID: PMC2891842.
    66. Ambrosone CB, Barlow WE, Reynolds W, Livingston RB, Yeh IT, Choi JY, Davis W, Rae JM, Tang L, Hutchins LR, Ravdin PM, Martino S, Osborne CK, Lyss AP, Hayes DF, Albain KS. Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897. J Clin Oncol. 2009 Oct 20; 27(30):4973-9. PMID: 19752340; PMCID: PMC2799053.
    67. Choi JY, Barlow WE, Albain KS, Hong CC, Blanco JG, Livingston RB, Davis W, Rae JM, Yeh IT, Hutchins LF, Ravdin PM, Martino S, Lyss AP, Osborne CK, Abeloff MD, Hayes DF, Ambrosone CB. Nitric oxide synthase variants and disease-free survival among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial. Clin Cancer Res. 2009 Aug 15; 15(16):5258-66. PMID: 19671875; PMCID: PMC2745926.
    68. Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, Sjolund A, Rimm DL, Wong H, Rodriguez A, Herschkowitz JI, Fan C, Zhang X, He X, Pavlick A, Gutierrez MC, Renshaw L, Larionov AA, Faratian D, Hilsenbeck SG, Perou CM, Lewis MT, Rosen JM, Chang JC. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):13820-5. PMID: 19666588; PMCID: PMC2720409.
    69. Hershman DL, Unger JM, Barlow WE, Hutchins LF, Martino S, Osborne CK, Livingston RB, Albain KS. Treatment quality and outcomes of African American versus white breast cancer patients: retrospective analysis of Southwest Oncology studies S8814/S8897. J Clin Oncol. 2009 May 1; 27(13):2157-62. PMID: 19307504; PMCID: PMC2674002.
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    157. Elledge RM, Green S, Pugh R, Allred DC, Clark GM, Hill J, Ravdin P, Martino S, Osborne CK. Estrogen receptor (ER) and progesterone receptor (PgR), by ligand-binding assay compared with ER, PgR and pS2, by immuno-histochemistry in predicting response to tamoxifen in metastatic breast cancer: a Southwest Oncology Group Study. Int J Cancer. 2000 Mar 20; 89(2):111-7. PMID: 10754487.
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    158. Oesterreich S, Zhang Q, Hopp T, Fuqua SA, Michaelis M, Zhao HH, Davie JR, Osborne CK, Lee AV. Tamoxifen-bound estrogen receptor (ER) strongly interacts with the nuclear matrix protein HET/SAF-B, a novel inhibitor of ER-mediated transactivation. Mol Endocrinol. 2000 Mar; 14(3):369-81. PMID: 10707955.
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    159. Chang J, Powles TJ, Allred DC, Ashley SE, Makris A, Gregory RK, Osborne CK, Dowsett M. Prediction of clinical outcome from primary tamoxifen by expression of biologic markers in breast cancer patients. Clin Cancer Res. 2000 Feb; 6(2):616-21. PMID: 10690547.
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    160. Chang J, Powles TJ, Allred DC, Ashley SE, Clark GM, Makris A, Assersohn L, Gregory RK, Osborne CK, Dowsett M. Biologic markers as predictors of clinical outcome from systemic therapy for primary operable breast cancer. J Clin Oncol. 1999 Oct; 17(10):3058-63. PMID: 10506600.
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    162. Jatoi I, Hilsenbeck SG, Clark GM, Osborne CK. Significance of axillary lymph node metastasis in primary breast cancer. J Clin Oncol. 1999 Aug; 17(8):2334-40. PMID: 10561295.
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    163. Osborne CK. Aromatase inhibitors in relation to other forms of endocrine therapy for breast cancer. Endocr Relat Cancer. 1999 Jun; 6(2):271-6. PMID: 10731120.
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    164. Lee AV, Jackson JG, Gooch JL, Hilsenbeck SG, Coronado-Heinsohn E, Osborne CK, Yee D. Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo. Mol Endocrinol. 1999 May; 13(5):787-96. PMID: 10319328.
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    165. Diab SG, Clark GM, Osborne CK, Libby A, Allred DC, Elledge RM. Tumor characteristics and clinical outcome of tubular and mucinous breast carcinomas. J Clin Oncol. 1999 May; 17(5):1442-8. PMID: 10334529.
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    166. Harvey JM, Clark GM, Osborne CK, Allred DC. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol. 1999 May; 17(5):1474-81. PMID: 10334533.
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    167. Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. J Biol Chem. 1999 Apr 16; 274(16):11334-8. PMID: 10196224.
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    168. Hilsenbeck SG, Friedrichs WE, Schiff R, O'Connell P, Hansen RK, Osborne CK, Fuqua SA. Statistical analysis of array expression data as applied to the problem of tamoxifen resistance. J Natl Cancer Inst. 1999 Mar 3; 91(5):453-9. PMID: 10070945.
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    169. Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26; 339(22):1609-18. PMID: 9828250.
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    170. Mansour EG, Gray R, Shatila AH, Tormey DC, Cooper MR, Osborne CK, Falkson G. Survival advantage of adjuvant chemotherapy in high-risk node-negative breast cancer: ten-year analysis--an intergroup study. J Clin Oncol. 1998 Nov; 16(11):3486-92. PMID: 9817265.
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    171. Geyer CE, Green SJ, Moinpour CM, O'Sullivan J, Goodwin DK, Canfield VA, Meyers FJ, Osborne CK, Martino S. Expanded phase II trial of paclitaxel in metastatic breast cancer: a Southwest Oncology Group study. Breast Cancer Res Treat. 1998 Sep; 51(2):169-81. PMID: 9879778.
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    172. Fetting JH, Gray R, Fairclough DL, Smith TJ, Margolin KA, Citron ML, Grove-Conrad M, Cella D, Pandya K, Robert N, Henderson IC, Osborne CK, Abeloff MD. Sixteen-week multidrug regimen versus cyclophosphamide, doxorubicin, and fluorouracil as adjuvant therapy for node-positive, receptor-negative breast cancer: an Intergroup study. J Clin Oncol. 1998 Jul; 16(7):2382-91. PMID: 9667255.
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    173. O'Connell P, Pekkel V, Fuqua SA, Osborne CK, Clark GM, Allred DC. Analysis of loss of heterozygosity in 399 premalignant breast lesions at 15 genetic loci. J Natl Cancer Inst. 1998 May 6; 90(9):697-703. PMID: 9586667.
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    174. Falkson G, Gelman RS, Pandya KJ, Osborne CK, Tormey D, Cummings FJ, Sledge GW, Abeloff MD. Eastern Cooperative Oncology Group randomized trials of observation versus maintenance therapy for patients with metastatic breast cancer in complete remission following induction treatment. J Clin Oncol. 1998 May; 16(5):1669-76. PMID: 9586877.
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    175. Diab SG, Hilsenbeck SG, de Moor C, Clark GM, Osborne CK, Ravdin PM, Elledge RM. Radiation therapy and survival in breast cancer patients with 10 or more positive axillary lymph nodes treated with mastectomy. J Clin Oncol. 1998 May; 16(5):1655-60. PMID: 9586875.
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    176. Ciocca DR, Green S, Elledge RM, Clark GM, Pugh R, Ravdin P, Lew D, Martino S, Osborne CK. Heat shock proteins hsp27 and hsp70: lack of correlation with response to tamoxifen and clinical course of disease in estrogen receptor-positive metastatic breast cancer (a Southwest Oncology Group Study). Clin Cancer Res. 1998 May; 4(5):1263-6. PMID: 9607585.
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    177. Berardo MD, Elledge RM, de Moor C, Clark GM, Osborne CK, Allred DC. bcl-2 and apoptosis in lymph node positive breast carcinoma. Cancer. 1998 Apr 1; 82(7):1296-302. PMID: 9529021.
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    178. Osborne CK, Elledge RM, Brown PH, Hilsenbeck SG. BRCA1 in clinical breast cancer. Breast Dis. 1998 Apr; 10(1-2):77-88. PMID: 15687551.
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    179. Lavinsky RM, Jepsen K, Heinzel T, Torchia J, Mullen TM, Schiff R, Del-Rio AL, Ricote M, Ngo S, Gemsch J, Hilsenbeck SG, Osborne CK, Glass CK, Rosenfeld MG, Rose DW. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2920-5. PMID: 9501191; PMCID: PMC19670.
    180. Taylor CW, Green S, Dalton WS, Martino S, Rector D, Ingle JN, Robert NJ, Budd GT, Paradelo JC, Natale RB, Bearden JD, Mailliard JA, Osborne CK. Multicenter randomized clinical trial of goserelin versus surgical ovariectomy in premenopausal patients with receptor-positive metastatic breast cancer: an intergroup study. J Clin Oncol. 1998 Mar; 16(3):994-9. PMID: 9508182.
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    181. Elledge RM, Green S, Ciocca D, Pugh R, Allred DC, Clark GM, Hill J, Ravdin P, O'Sullivan J, Martino S, Osborne CK. HER-2 expression and response to tamoxifen in estrogen receptor-positive breast cancer: a Southwest Oncology Group Study. Clin Cancer Res. 1998 Jan; 4(1):7-12. PMID: 9516946.
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    183. Hilsenbeck SG, Ravdin PM, de Moor CA, Chamness GC, Osborne CK, Clark GM. Time-dependence of hazard ratios for prognostic factors in primary breast cancer. Breast Cancer Res Treat. 1998; 52(1-3):227-37. PMID: 10066085.
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    184. Clark GM, Osborne CK, Levitt D, Wu F, Kim NW. Telomerase activity and survival of patients with node-positive breast cancer. J Natl Cancer Inst. 1997 Dec 17; 89(24):1874-81. PMID: 9414175.
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    185. Clark GM, Allred DC, Hilsenbeck SG, Chamness GC, Osborne CK, Jones D, Lee WH. Mitosin (a new proliferation marker) correlates with clinical outcome in node-negative breast cancer. Cancer Res. 1997 Dec 15; 57(24):5505-8. PMID: 9407959.
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    186. Johnston SR, Lu B, Dowsett M, Liang X, Kaufmann M, Scott GK, Osborne CK, Benz CC. Comparison of estrogen receptor DNA binding in untreated and acquired antiestrogen-resistant human breast tumors. Cancer Res. 1997 Sep 1; 57(17):3723-7. PMID: 9288779.
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    187. Russell CA, Green SJ, O'Sullivan J, Hynes HE, Budd GT, Congdon JE, Martino S, Osborne CK. Megestrol acetate and aminoglutethimide/hydrocortisone in sequence or in combination as second-line endocrine therapy of estrogen receptor-positive metastatic breast cancer: a Southwest Oncology Group phase III trial. J Clin Oncol. 1997 Jul; 15(7):2494-501. PMID: 9215817.
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    190. Makris A, Allred DC, Powles TJ, Dowsett M, Fernando IN, Trott PA, Ashley SE, Ormerod MG, Titley JC, Osborne CK. Cytological evaluation of biological prognostic markers from primary breast carcinomas. Breast Cancer Res Treat. 1997 May; 44(1):65-74. PMID: 9164679.
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    191. Elledge RM, Green S, Howes L, Clark GM, Berardo M, Allred DC, Pugh R, Ciocca D, Ravdin P, O'Sullivan J, Rivkin S, Martino S, Osborne CK. bcl-2, p53, and response to tamoxifen in estrogen receptor-positive metastatic breast cancer: a Southwest Oncology Group study. J Clin Oncol. 1997 May; 15(5):1916-22. PMID: 9164202.
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    192. Grøndahl-Hansen J, Hilsenbeck SG, Christensen IJ, Clark GM, Osborne CK, Brünner N. Prognostic significance of PAI-1 and uPA in cytosolic extracts obtained from node-positive breast cancer patients. Breast Cancer Res Treat. 1997 Apr; 43(2):153-63. PMID: 9131271.
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    193. Makris A, Powles TJ, Dowsett M, Osborne CK, Trott PA, Fernando IN, Ashley SE, Ormerod MG, Titley JC, Gregory RK, Allred DC. Prediction of response to neoadjuvant chemoendocrine therapy in primary breast carcinomas. Clin Cancer Res. 1997 Apr; 3(4):593-600. PMID: 9815725.
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    194. Albain KS, Green SR, Lichter AS, Hutchins LF, Wood WC, Henderson IC, Ingle JN, O'Sullivan J, Osborne CK, Martino S. Influence of patient characteristics, socioeconomic factors, geography, and systemic risk on the use of breast-sparing treatment in women enrolled in adjuvant breast cancer studies: an analysis of two intergroup trials. J Clin Oncol. 1996 Nov; 14(11):3009-17. PMID: 8918499.
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    195. Osborne CK. Aromatase inhibitors in the treatment of advanced breast cancer. Introduction. Semin Oncol. 1996 Aug; 23(4 Suppl 9):1. PMID: 8824458.
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    198. Nicholson RI, Gee JM, Bryant S, Francis AB, McClelland RA, Knowlden J, Wakeling AE, Osborne CK. Pure antiestrogens. The most important advance in the endocrine therapy of breast cancer since 1896. Ann N Y Acad Sci. 1996 Apr 30; 784:325-35. PMID: 8651581.
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    199. Gelber RD, Cole BF, Goldhirsch A, Rose C, Fisher B, Osborne CK, Boccardo F, Gray R, Gordon NH, Bengtsson NO, Sevelda P. Adjuvant chemotherapy plus tamoxifen compared with tamoxifen alone for postmenopausal breast cancer: meta-analysis of quality-adjusted survival. Lancet. 1996 Apr 20; 347(9008):1066-71. PMID: 8602056.
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    200. Chen Y, Chen PL, Riley DJ, Lee WH, Allred DC, Osborne CK. Response: Location of BRCA1 in Human Breast and Ovarian Cancer Cells. Science. 1996 Apr 5; 272(5258):125-6. PMID: 17789966.
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    202. Rivkin SE, Green S, O'Sullivan J, Cruz AB, Abeloff MD, Jewell WR, Costanzi JJ, Farrar WB, Osborne CK. Adjuvant CMFVP versus adjuvant CMFVP plus ovariectomy for premenopausal, node-positive, and estrogen receptor-positive breast cancer patients: a Southwest Oncology Group study. J Clin Oncol. 1996 Jan; 14(1):46-51. PMID: 8558219.
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    204. Isola JJ, Kallioniemi OP, Chu LW, Fuqua SA, Hilsenbeck SG, Osborne CK, Waldman FM. Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer. Am J Pathol. 1995 Oct; 147(4):905-11. PMID: 7573366; PMCID: PMC1871005.
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    208. Rønne E, Høyer-Hansen G, Brünner N, Pedersen H, Rank F, Osborne CK, Clark GM, Danø K, Grøndahl-Hansen J. Urokinase receptor in breast cancer tissue extracts. Enzyme-linked immunosorbent assay with a combination of mono- and polyclonal antibodies. Breast Cancer Res Treat. 1995 Mar; 33(3):199-207. PMID: 7749147.
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    210. Fabian CJ, Kimler BF, McKittrick R, Park CH, Lin F, Krishnan L, Jewell WR, Osborne CK, Martino S, Hutchins LF, et al. Recruitment with high physiological doses of estradiol preceding chemotherapy: flow cytometric and therapeutic results in women with locally advanced breast cancers--a Southwest Oncology Group study. Cancer Res. 1994 Oct 15; 54(20):5357-62. PMID: 7923165.
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    211. Rivkin SE, Green S, Metch B, Cruz AB, Abeloff MD, Jewell WR, Costanzi JJ, Farrar WB, Minton JP, Osborne CK. Adjuvant CMFVP versus tamoxifen versus concurrent CMFVP and tamoxifen for postmenopausal, node-positive, and estrogen receptor-positive breast cancer patients: a Southwest Oncology Group study. J Clin Oncol. 1994 Oct; 12(10):2078-85. PMID: 7931477.
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    213. Elledge RM, Clark GM, Chamness GC, Osborne CK. Tumor biologic factors and breast cancer prognosis among white, Hispanic, and black women in the United States. J Natl Cancer Inst. 1994 May 4; 86(9):705-12. PMID: 7908990.
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    214. Stein D, Wu J, Fuqua SA, Roonprapunt C, Yajnik V, D'Eustachio P, Moskow JJ, Buchberg AM, Osborne CK, Margolis B. The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer. EMBO J. 1994 Mar 15; 13(6):1331-40. PMID: 7907978; PMCID: PMC394949.
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    218. Atiba JO, Green SJ, Hynes HE, Osborne CK, Miller TP, Davidner M. Phase II evaluation of mitoxantrone plus cis-platinum in patients with advanced breast cancer. A Southwest Oncology Group study. Invest New Drugs. 1994; 12(2):129-32. PMID: 7860229.
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    219. Osborne CK, Fuqua SA. Mechanisms of tamoxifen resistance. Breast Cancer Res Treat. 1994; 32(1):49-55. PMID: 7819585.
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    220. Osborne CK, Chamness GC. Translational research in the San Antonio breast cancer SPORE. Breast Cancer Res Treat. 1994; 32(1):1-4. PMID: 7819578.
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    223. Fuqua SA, Oesterreich S, Hilsenbeck SG, Von Hoff DD, Eckardt J, Osborne CK. Heat shock proteins and drug resistance. Breast Cancer Res Treat. 1994; 32(1):67-71. PMID: 7819588.
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    227. Oesterreich S, Weng CN, Qiu M, Hilsenbeck SG, Osborne CK, Fuqua SA. The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Res. 1993 Oct 1; 53(19):4443-8. PMID: 8402609.
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    228. Hayden KA, Moinpour CM, Metch B, Feigl P, O'Bryan RM, Green S, Osborne CK. Pitfalls in quality-of-life assessment: lessons from a Southwest Oncology Group breast cancer clinical trial. Oncol Nurs Forum. 1993 Oct; 20(9):1415-9. PMID: 8265446.
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    229. Rivkin SE, Green S, Metch B, Jewell WR, Costanzi JJ, Altman SJ, Minton JP, O'Bryan RM, Osborne CK. One versus 2 years of CMFVP adjuvant chemotherapy in axillary node-positive and estrogen receptor-negative patients: a Southwest Oncology Group study. J Clin Oncol. 1993 Sep; 11(9):1710-6. PMID: 8355037.
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    232. Encarnación CA, Ciocca DR, McGuire WL, Clark GM, Fuqua SA, Osborne CK. Measurement of steroid hormone receptors in breast cancer patients on tamoxifen. Breast Cancer Res Treat. 1993; 26(3):237-46. PMID: 8251648.
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    233. Allred DC, Clark GM, Molina R, Tandon AK, Schnitt SJ, Gilchrist KW, Osborne CK, Tormey DC, McGuire WL. Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer. Hum Pathol. 1992 Sep; 23(9):974-9. PMID: 1355464.
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    235. Wiebe VJ, Osborne CK, McGuire WL, DeGregorio MW. Identification of estrogenic tamoxifen metabolite(s) in tamoxifen-resistant human breast tumors. J Clin Oncol. 1992 Jun; 10(6):990-4. PMID: 1588380.
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    236. Elledge RM, McGuire WL, Osborne CK. Prognostic factors in breast cancer. Semin Oncol. 1992 Jun; 19(3):244-53. PMID: 1351692.
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    237. Osborne CK. Prognostic factors for breast cancer: have they met their promise? J Clin Oncol. 1992 May; 10(5):679-82. PMID: 1569440.
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    240. Osborne CK. Polypeptide growth factors: their potential value in the management of breast cancer patients. Cancer Treat Res. 1992; 60:315-29. PMID: 1355995.
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    241. Dressler LG, Eudey L, Gray R, Tormey DC, McGuire WL, Gilchrist KW, Clark GM, Osborne CK, Mansour EG, Abeloff MD. Prognostic potential of DNA flow cytometry measurements in node-negative breast cancer patients: preliminary analysis of an intergroup study (INT 0076). J Natl Cancer Inst Monogr. 1992; (11):167-72. PMID: 1627424.
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    242. Osborne CK, Blumenstein BA, Crawford ED, Weiss GR, Bukowski RM, Larrimer NR. Phase II study of platinum and mitoxantrone in metastatic prostate cancer: a Southwest Oncology Group Study. Eur J Cancer. 1992; 28(2-3):477-8. PMID: 1591066.
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    243. Albain KS, Green S, LeBlanc M, Rivkin S, O'Sullivan J, Osborne CK. Proportional hazards and recursive partitioning and amalgamation analyses of the Southwest Oncology Group node-positive adjuvant CMFVP breast cancer data base: a pilot study. Breast Cancer Res Treat. 1992; 22(3):273-84. PMID: 1391993.
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    244. Mansour EG, Eudey L, Tormey DC, Shatila AH, Osborne CK, Gilchrist KW, Cooper MR, Falkson G. Chemotherapy versus observation in high-risk node-negative breast cancer patients. J Natl Cancer Inst Monogr. 1992; (11):97-104. PMID: 1627437.
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    245. Benz CC, Scott GK, Sarup JC, Johnson RM, Tripathy D, Coronado E, Shepard HM, Osborne CK. Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu. Breast Cancer Res Treat. 1992; 24(2):85-95. PMID: 8095168.
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    246. Osborne CK. Dose intensity as a therapeutic strategy in breast cancer. Breast Cancer Res Treat. 1991 Dec; 20 Suppl:S11-4. PMID: 1687202.
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    247. Osborne CK. Hematopoietic growth factors in breast cancer--overview. Breast Cancer Res Treat. 1991 Dec; 20 Suppl:S1-2. PMID: 1806028.
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    248. Osborne CK, Coronado E, Allred DC, Wiebe V, DeGregorio M. Acquired tamoxifen resistance: correlation with reduced breast tumor levels of tamoxifen and isomerization of trans-4-hydroxytamoxifen. J Natl Cancer Inst. 1991 Oct 16; 83(20):1477-82. PMID: 1920493.
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    249. Budd GT, Green S, Baker LH, Hersh EP, Weick JK, Osborne CK. A Southwest Oncology Group phase II Trial of recombinant tumor necrosis factor in metastatic breast cancer. Cancer. 1991 Oct 15; 68(8):1694-5. PMID: 1913510.
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    250. Cowan JD, Neidhart J, McClure S, Coltman CA, Gumbart C, Martino S, Hutchins LF, Stephens RL, Vaughan CB, Osborne CK. Randomized trial of doxorubicin, bisantrene, and mitoxantrone in advanced breast cancer: a Southwest Oncology Group study. J Natl Cancer Inst. 1991 Aug 7; 83(15):1077-84. PMID: 1875415.
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    251. Sunderland MC, Osborne CK. Tamoxifen in premenopausal patients with metastatic breast cancer: a review. J Clin Oncol. 1991 Jul; 9(7):1283-97. PMID: 2045868.
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    252. Reddy KB, Yee D, Osborne CK. Rapid identification of transfected plasmid expression vectors in cells by PCR. Biotechniques. 1991 Apr; 10(4):481-2, 484. PMID: 1867857.
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    253. Von Hoff DD, Green SJ, Neidhart JA, Fabian C, Budd T, Boyd JF, Osborne CK. Phase II study of L-alanosine (NSC 153353) in patients with advanced breast cancer. A Southwest Oncology Group study. Invest New Drugs. 1991 Feb; 9(1):87-8. PMID: 2026487.
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    254. Arteaga CL, Osborne CK. Growth factors as mediators of estrogen/antiestrogen action in human breast cancer cells. Cancer Treat Res. 1991; 53:289-304. PMID: 1672083.
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    255. Osborne CK, Clemmons DR, Arteaga CL. Regulation of breast cancer growth by insulin-like growth factors. J Steroid Biochem Mol Biol. 1990 Dec 20; 37(6):805-9. PMID: 2178363.
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    256. Clemmons DR, Camacho-Hubner C, Coronado E, Osborne CK. Insulin-like growth factor binding protein secretion by breast carcinoma cell lines: correlation with estrogen receptor status. Endocrinology. 1990 Dec; 127(6):2679-86. PMID: 1701124.
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    257. Osborne CK, Blumenstein B, Crawford ED, Coltman CA, Smith AY, Lambuth BW, Chapman RA. Combined versus sequential chemo-endocrine therapy in advanced prostate cancer: final results of a randomized Southwest Oncology Group study. J Clin Oncol. 1990 Oct; 8(10):1675-82. PMID: 2213104.
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    258. Osborne CK, Arteaga CL. Autocrine and paracrine growth regulation of breast cancer: clinical implications. Breast Cancer Res Treat. 1990 Jan; 15(1):3-11. PMID: 2183891.
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    259. Merkel DE, Osborne CK. Prognostic factors in breast cancer. Hematol Oncol Clin North Am. 1989 Dec; 3(4):641-52. PMID: 2558104.
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    260. Arteaga CL, Osborne CK. Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor. Cancer Res. 1989 Nov 15; 49(22):6237-41. PMID: 2553250.
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    261. Arteaga CL, Kitten LJ, Coronado EB, Jacobs S, Kull FC, Allred DC, Osborne CK. Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice. J Clin Invest. 1989 Nov; 84(5):1418-23. PMID: 2553774; PMCID: PMC304004.
    262. Osborne CK, Coronado EB, Kitten LJ, Arteaga CI, Fuqua SA, Ramasharma K, Marshall M, Li CH. Insulin-like growth factor-II (IGF-II): a potential autocrine/paracrine growth factor for human breast cancer acting via the IGF-I receptor. Mol Endocrinol. 1989 Nov; 3(11):1701-9. PMID: 2558302.
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    263. McGuire WL, Johnson PA, Muss HB, Osborne CK. Megestrol acetate in breast cancer--a panel discussion. Breast Cancer Res Treat. 1989 Oct; 14(1):33-8. PMID: 2605342.
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    264. Osborne CK. DNA flow cytometry in early breast cancer: a step in the right direction. J Natl Cancer Inst. 1989 Sep 20; 81(18):1344-5. PMID: 2778818.
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    265. Liu E, Santos G, Lee WM, Osborne CK, Benz CC. Effects of c-myc overexpression on the growth characteristics of MCF-7 human breast cancer cells. Oncogene. 1989 Aug; 4(8):979-84. PMID: 2668848.
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    266. Osborne CK, Craig JB, Klein K, Crawford ED, Turner J. Phase II trial of a new biological response modifier (ImuVert) in advanced prostate cancer. Invest New Drugs. 1989 Jul; 7(2-3):243-5. PMID: 2793381.
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    267. Osborne CK, Kitten L, Arteaga CL. Antagonism of chemotherapy-induced cytotoxicity for human breast cancer cells by antiestrogens. J Clin Oncol. 1989 Jun; 7(6):710-7. PMID: 2715802.
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    268. McGuire WL, Abeloff MD, Fisher B, Glick JH, Henderson IC, Osborne CK. Adjuvant therapy in node-negative breast cancer. A panel discussion. Breast Cancer Res Treat. 1989 Mar; 13(2):97-115. PMID: 2659105.
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    269. Mansour EG, Gray R, Shatila AH, Osborne CK, Tormey DC, Gilchrist KW, Cooper MR, Falkson G. Efficacy of adjuvant chemotherapy in high-risk node-negative breast cancer. An intergroup study. N Engl J Med. 1989 Feb 23; 320(8):485-90. PMID: 2915651.
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    270. Dorr RT, Liddil JD, Von Hoff DD, Soble M, Osborne CK. Antitumor activity and murine pharmacokinetics of parenteral acronycine. Cancer Res. 1989 Jan 15; 49(2):340-4. PMID: 2910453.
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    271. Merkel DE, Osborne CK. Adjuvant treatment of node-negative breast cancer. Tex Med. 1989 Jan; 85(1):32-6. PMID: 2922686.
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    272. Robert NJ, Dalton WS, Osborne CK, Abeloff M. Therapy in premenopausal women with advanced, oestrogen positive or/and progesterone positive breast cancer: surgical oophorectomy versus the LHRH analogue, Zoladex. Horm Res. 1989; 32 Suppl 1:221-2. PMID: 2533155.
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    273. Osborne CK. Cell proliferative indices and DNA content as prognostic factors in primary breast cancer. Horm Res. 1989; 32 Suppl 1:238-41. PMID: 2613209.
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    274. DeGregorio MW, Coronado E, Osborne CK. Tumor and serum tamoxifen concentrations in the athymic nude mouse. Cancer Chemother Pharmacol. 1989; 23(2):68-70. PMID: 2910513.
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    275. McGuire WL, Foley KM, Levy MH, Osborne CK. Pain control in breast cancer. A panel discussion. Breast Cancer Res Treat. 1989 Jan; 13(1):5-15. PMID: 2565124.
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    276. Arteaga CL, Coronado E, Osborne CK. Blockade of the epidermal growth factor receptor inhibits transforming growth factor alpha-induced but not estrogen-induced growth of hormone-dependent human breast cancer. Mol Endocrinol. 1988 Nov; 2(11):1064-9. PMID: 3221874.
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    277. McGuire WL, Dickson RB, Osborne CK, Salomon D. The role of growth factors in breast cancer. A panel discussion. Breast Cancer Res Treat. 1988 Oct; 12(2):159-66. PMID: 3242646.
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    278. Arteaga CL, Hanauske AR, Clark GM, Osborne CK, Hazarika P, Pardue RL, Tio F, Von Hoff DD. Immunoreactive alpha transforming growth factor activity in effusions from cancer patients as a marker of tumor burden and patient prognosis. Cancer Res. 1988 Sep 1; 48(17):5023-8. PMID: 3165707.
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    279. Arteaga CL, Tandon AK, Von Hoff DD, Osborne CK. Transforming growth factor beta: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells. Cancer Res. 1988 Jul 15; 48(14):3898-904. PMID: 3164252.
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    280. Osborne CK, Ross CR, Coronado EB, Fuqua SA, Kitten LJ. Secreted growth factors from estrogen receptor-negative human breast cancer do not support growth of estrogen receptor-positive breast cancer in the nude mouse model. Breast Cancer Res Treat. 1988 Jul; 11(3):211-9. PMID: 3167228.
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    281. Brünner N, Osborne CK, Spang-Thomsen M. Endocrine therapy of human breast cancer grown in nude mice. Breast Cancer Res Treat. 1987 Dec; 10(3):229-42. PMID: 3328985.
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    282. Osborne CK, Coronado EB, Robinson JP. Human breast cancer in the athymic nude mouse: cytostatic effects of long-term antiestrogen therapy. Eur J Cancer Clin Oncol. 1987 Aug; 23(8):1189-96. PMID: 3653212.
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    283. Hanauske AR, Osborne CK, Chamness GC, Clark GM, Forseth BJ, Buchok JB, Arteaga CL, Von Hoff DD. Alteration of EGF-receptor binding in human breast cancer cells by antineoplastic agents. Eur J Cancer Clin Oncol. 1987 May; 23(5):545-51. PMID: 3498632.
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    284. Clark GM, Sledge GW, Osborne CK, McGuire WL. Survival from first recurrence: relative importance of prognostic factors in 1,015 breast cancer patients. J Clin Oncol. 1987 Jan; 5(1):55-61. PMID: 3806159.
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    285. McGuire WL, Lippman ME, Osborne CK, Thompson EB. Resistance to endocrine therapy. A panel discussion. Breast Cancer Res Treat. 1987; 9(3):165-73. PMID: 3663953.
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    286. DeGregorio MW, Wilbur BJ, Coronado E, Osborne CK. Serum tamoxifen concentrations in the athymic nude mouse after three methods of administration. Cancer Chemother Pharmacol. 1987; 20(4):316-8. PMID: 3690805.
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    287. Osborne CK, Hobbs K, Trent JM. Biological differences among MCF-7 human breast cancer cell lines from different laboratories. Breast Cancer Res Treat. 1987; 9(2):111-21. PMID: 3620713.
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    288. Graham KA, Trent JM, Osborne CK, McGrath CM, Minden MD, Buick RN. The use of restriction fragment polymorphisms to identify the cell line MCF-7. Breast Cancer Res Treat. 1986; 8(1):29-34. PMID: 3790748.
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    289. Osborne CK, Rivkin SE, McDivitt RW, Green S, Stephens RL, Costanzi JJ, O'Bryan R. Adjuvant therapy of breast cancer: Southwest Oncology Group studies. NCI Monogr. 1986; (1):71-4. PMID: 3534592.
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    290. Osborne CK, Coltman CA. Adjuvant chemotherapy. CA Cancer J Clin. 1986 Jan-Feb; 36(1):59-60. PMID: 3080209.
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    291. Rivkin SE, Knight WA, McDivitt R, Cruz T, Foulkes M, Osborne CK, Fabian CJ, Costanzi JJ. Adjuvant therapy for breast cancer with positive axillary nodes designed according to estrogen receptor status. J Steroid Biochem. 1985 Dec; 23(6B):1151-4. PMID: 3912621.
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    292. Rivkin SE, Glucksberg H, Foulkes M, Osborne CK, Tranum W, Gad-el-Mawla N, Constanzi J. Adjuvant chemotherapy for operable breast cancer with positive axillary nodes: a comparison of CMFVP versus L-PAM. World J Surg. 1985 Oct; 9(5):719-22. PMID: 3840628.
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    293. Rivkin SE, Knight WA, McDivitt R, Cruz T, Foulkes M, Osborne CK, Fabian CJ, Costanzi JJ. Adjuvant therapy for breast cancer with positive axillary nodes designed according to estrogen receptor status. World J Surg. 1985 Oct; 9(5):723-7. PMID: 3840629.
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    294. Osborne CK. Heterogeneity in hormone receptor status in primary and metastatic breast cancer. Semin Oncol. 1985 Sep; 12(3):317-26. PMID: 3901267.
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    295. Osborne CK, Hobbs K, Clark GM. Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice. Cancer Res. 1985 Feb; 45(2):584-90. PMID: 3967234.
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    296. Cowan JD, Osborne CK, Neidhart JA, Von Hoff DD, Constanzi JJ, Vaughn CB. A randomized trial of doxorubicin, mitoxantrone and bisantrene in advanced breast cancer (a South West Oncology Group Study). Invest New Drugs. 1985; 3(2):149-52. PMID: 3894277.
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    297. Osborne CK, Von Hoff DD, Mullins K. Endocrine therapy testing of human breast cancers in the soft agar clonogenic assay. Breast Cancer Res Treat. 1985; 6(3):229-35. PMID: 2936413.
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    298. Coltman CA, Osborne CK. Bisantrene, biological and clinical effects. Cancer Treat Rev. 1984 Dec; 11(4):285-8. PMID: 6534510.
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    299. Osborne CK. Hormone receptors in the management of breast cancer. Tex Med. 1984 Nov; 80(11):30-2. PMID: 6515569.
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    300. Clark GM, Osborne CK, McGuire WL. Correlations between estrogen receptor, progesterone receptor, and patient characteristics in human breast cancer. J Clin Oncol. 1984 Oct; 2(10):1102-9. PMID: 6491696.
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    301. Gross GE, Boldt DH, Osborne CK. Perturbation by insulin of human breast cancer cell cycle kinetics. Cancer Res. 1984 Aug; 44(8):3570-5. PMID: 6378371.
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    302. Osborne CK, Boldt DH, Estrada P. Human breast cancer cell cycle synchronization by estrogens and antiestrogens in culture. Cancer Res. 1984 Apr; 44(4):1433-9. PMID: 6704960.
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    303. Osborne CK, Von Hoff DD, Cowan JD, Sandbach J. Bisantrene, an active drug in patients with advanced breast cancer. Cancer Treat Rep. 1984 Feb; 68(2):357-60. PMID: 6697324.
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    304. Osborne CK, Drelichman A, Von Hoff DD, Crawford ED. Mitoxantrone: modest activity in a phase II trial in advanced prostate cancer. Cancer Treat Rep. 1983 Dec; 67(12):1133-5. PMID: 6652630.
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    305. Ibbotson KJ, D'Souza SM, Ng KW, Osborne CK, Niall M, Martin TJ, Mundy GR. Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy. Science. 1983 Sep 23; 221(4617):1292-4. PMID: 6577602.
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    306. Osborne CK, Boldt DH, Clark GM, Trent JM. Effects of tamoxifen on human breast cancer cell cycle kinetics: accumulation of cells in early G1 phase. Cancer Res. 1983 Aug; 43(8):3583-5. PMID: 6861130.
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    307. Garvin AJ, Simon RM, Osborne CK, Merrill J, Young RC, Berard CW. An autopsy study of histologic progression in non-Hodgkin's lymphomas. 192 cases from the National Cancer Institute. Cancer. 1983 Aug 1; 52(3):393-8. PMID: 6344979.
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    308. Hull DF, Clark GM, Osborne CK, Chamness GC, Knight WA, McGuire WL. Multiple estrogen receptor assays in human breast cancer. Cancer Res. 1983 Jan; 43(1):413-6. PMID: 6847780.
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    309. Myers JW, Von Hoff DD, Kuhn JG, Osborne CK, Sandbach JF, Pocelinko R. Anaphylactoid reactions associated with bisantrene infusions. Invest New Drugs. 1983; 1(1):85-8. PMID: 6678858.
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    310. Monaco ME, Osborne CK, Bronzert TJ, Kidwell WR, Lippman ME. Characterization of insulin regulation of lipid synthesis in MCF-7 human breast cancer cells. Breast Cancer Res Treat. 1983; 3(3):279-85. PMID: 6367855.
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    311. McGuire WL, Osborne CK, Clark GM, Knight WA. Steroid hormone receptors and carcinoma of the breast. Am J Physiol. 1982 Aug; 243(2):E99-102. PMID: 7114210.
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    312. Hubbard SM, Chabner BA, DeVita VT, Simon R, Berard CW, Jones RB, Garvin AJ, Canellos GP, Osborne CK, Young RC. Histologic progression in non-Hodgkin's lymphoma. Blood. 1982 Feb; 59(2):258-64. PMID: 7034812.
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    313. Suarez AJ, Lamm DL, Radwin HM, Sarosdy M, Clark G, Osborne CK. Androgen priming and cytotoxic chemotherapy in advanced prostatic cancer. Cancer Chemother Pharmacol. 1982; 8(3):261-5. PMID: 7127658.
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    314. Elson DL, Osborne CK, Livingston RB, Von Hoff DD. Methods for determining chemosensitivity of MCF-7 cells in double-layer agar culture: labeling index depression and colony count inhibition. Stem Cells. 1982; 2(1):34-44. PMID: 7157082.
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    315. Osborne CK, Hamilton B, Nover M, Ziegler J. Antagonism between epidermal growth factor and phorbol ester tumor promoters in human breast cancer cells. J Clin Invest. 1981 Apr; 67(4):943-51. PMID: 6259217; PMCID: PMC370651.
    316. Von Hoff DD, Sandbach J, Osborne CK, Metelmann C, Clark GM, O'Brien M. Potential and problems with growth of breast cancer in a human tumor cloning system. Breast Cancer Res Treat. 1981; 1(2):141-8. PMID: 7348571.
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    317. Osborne CK. Combined chemo-hormonal therapy in breast cancer: a hypothesis. Breast Cancer Res Treat. 1981; 1(2):121-3. PMID: 7348568.
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    318. Knight WA, Clark GM, Osborne CK, McGuire WL. Adjuvant therapy for stage II, estrogen receptor negative breast cancer. Breast Cancer Res Treat. 1981; 1(2):131-4. PMID: 7348569.
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    319. Osborne CK, Fisher E, Redmond C, Knight WA, Yochmowitz MG, McGuire WL. Estrogen receptor, a marker for human breast cancer differentiation and patient prognosis. Adv Exp Med Biol. 1981; 138:377-85. PMID: 7342719.
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    320. Fisher ER, Osborne CK, McGuire WL, Redmond C, Knight WA, Fisher B, Bannayan G, Walder A, Gregory EJ, Jacobsen A, Queen DM, Bennett DE, Ford HC. Correlation of primary breast cancer histopathology and estrogen receptor content. Breast Cancer Res Treat. 1981; 1(1):37-41. PMID: 7348564.
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    321. Osborne CK, Yochmowitz MG, Knight WA, McGuire WL. The value of estrogen and progesterone receptors in the treatment of breast cancer. Cancer. 1980 Dec 15; 46(12 Suppl):2884-8. PMID: 7448733.
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    322. Osborne CK, Knight WA, Yochmowitz MG, McGuire WL. Modern approaches to the treatment of breast cancer. Blood. 1980 Nov; 56(5):745-52. PMID: 7426746.
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    323. Knight WA, Osborne CK, Yochmowitz MG, McGuire WL. Steroid hormone receptors in the management of human breast cancer. Ann Clin Res. 1980 Oct; 12(5):202-7. PMID: 7015982.
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    324. Osborne CK, Hamilton B, Titus G, Livingston RB. Epidermal growth factor stimulation of human breast cancer cells in culture. Cancer Res. 1980 Jul; 40(7):2361-6. PMID: 6966967.
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    325. Knight WA, Osborne CK, McGuire WL. Hormone receptors in primary and advanced breast cancer. Clin Endocrinol Metab. 1980 Jul; 9(2):361-8. PMID: 6249524.
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    326. Osborne CK, Norton L, Young RC, Garvin AJ, Simon RM, Berard CW, Hubbard S, DeVita VT. Nodular histiocytic lymphoma: an aggressive nodular lymphoma with potential for prolonged disease-free survival. Blood. 1980 Jul; 56(1):98-103. PMID: 6992889.
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    327. Gaskill SP, McGuire WL, Osborne CK, Stern MP. Breast cancer mortality and diet in the United States. Cancer Res. 1979 Sep; 39(9):3628-37. PMID: 582576.
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    328. Osborne CK, Monaco ME, Kahn CR, Huff K, Bronzert D, Lippman ME. Direct inhibition of growth and antagonism of insulin action by glucocorticoids in human breast cancer cells in culture. Cancer Res. 1979 Jul; 39(7 Pt 1):2422-8. PMID: 445441.
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    329. Osborne CK, McGuire WL. Therapy for cancer of the breast. Current status of steroid hormone receptors. West J Med. 1979 May; 130(5):401-7. PMID: 516664; PMCID: PMC1238656.
    330. Osborne CK, McGuire WL. The use of steroïd hormone receptors in the treatment of human breast cancer: a review. Bull Cancer. 1979; 66(3):203-9. PMID: 385079.
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    331. Osborne CK, McGuire WL. Current use of steroid hormone receptor assays in the treatment of breast cancer. Surg Clin North Am. 1978 Aug; 58(4):777-88. PMID: 684560.
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    332. Osborne CK, Monaco ME, Lippman ME, Kahn CR. Correlation among insulin binding, degradation, and biological activity in human breast cancer cells in long-term tissue culture. Cancer Res. 1978 Jan; 38(1):94-102. PMID: 22400.
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    333. Monaco ME, Osborne CK, Lippman ME. Insulin stimulation of fatty acid synthesis in human breast cancer cells. J Natl Cancer Inst. 1977 Jun; 58(6):1591-3. PMID: 559098.
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    334. Lippman ME, Osborne CK, Knazek R, Young N. In vitro model systems for the study of hormone-dependent human breast cancer. N Engl J Med. 1977 Jan 20; 296(3):154-9. PMID: 187935.
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    335. Osborne CK, Bolan G, Monaco ME, Lippman ME. Hormone responsive human breast cancer in long-term tissue culture: effect of insulin. Proc Natl Acad Sci U S A. 1976 Dec; 73(12):4536-40. PMID: 1070004; PMCID: PMC431532.
    336. Woolley PV, Osborne CK, Levi JA, Wiernik PH, Canellos GP. Extranodal presentation of non-Hodgkin's lymphomas in the testis. Cancer. 1976 Aug; 38(2):1026-35. PMID: 788888.
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    337. Osborne CK, Carolla R, Jefferson D, Mengel CE. Effect of methemoglobin on in vivo RBC lipid peroxidation. Aerosp Med. 1973 Jan; 44(1):63-7. PMID: 4689488.
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    338. Osborne CK, Brubaker LH, Mengel CE. Effects of hyperoxia on white blood cells. I. In vivo changes in the total white blood cell counts of normal rats. Aerosp Med. 1970 Oct; 41(10):1176-9. PMID: 5458201.
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