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ALEXANDER I AGOULNIK

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Obstetrics & Gynecology
DivisionObstet & Gyne: Reprod Genetics
AddressOne Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kocan M, Sarwar M, Ang SY, Xiao J, Marugan JJ, Hossain MA, Wang C, Hutchinson DS, Samuel CS, Agoulnik AI, Bathgate RAD, Summers RJ. ML290 is a biased allosteric agonist at the relaxin receptor RXFP1. Sci Rep. 2017 Jun 07; 7(1):2968. PMID: 28592882.
      View in: PubMed
    2. Ivell R, Agoulnik AI, Anand-Ivell R. Relaxin-like peptides in male reproduction - a human perspective. Br J Pharmacol. 2016 Dec 09. PMID: 27933606.
      View in: PubMed
    3. Agoulnik AI, Agoulnik IU, Hu X, Marugan J. Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1. Br J Pharmacol. 2016 Oct 23. PMID: 27771940.
      View in: PubMed
    4. Lopez SM, Agoulnik AI, Zhang M, Peterson LE, Suarez E, Gandarillas GA, Frolov A, Li R, Rajapakshe K, Coarfa C, Ittmann MM, Weigel NL, Agoulnik IU. Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression. Clin Cancer Res. 2016 Aug 1; 22(15):3937-49. PMID: 26968201; PMCID: PMC4970919 [Available on 08/01/17].
    5. Hu X, Myhr C, Huang Z, Xiao J, Barnaeva E, Ho BA, Agoulnik IU, Ferrer M, Marugan JJ, Southall N, Agoulnik AI. Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists. Biochemistry. 2016 Mar 29; 55(12):1772-83. PMID: 26866459.
      View in: PubMed
    6. Ferguson L, Kaftanovskaya EM, Manresa C, Barbara AM, Poppiti RJ, Tan Y, Agoulnik AI. Constitutive Notch Signaling Causes Abnormal Development of the Oviducts, Abnormal Angiogenesis, and Cyst Formation in Mouse Female Reproductive Tract. Biol Reprod. 2016 Mar; 94(3):67. PMID: 26843448.
      View in: PubMed
    7. Agoulnik IU, Agoulnik AI. Long-Lasting Consequences of Testosterone Exposure. Endocrinology. 2015 Oct; 156(10):3488-9. PMID: 26380936.
      View in: PubMed
    8. Huang Z, Myhr C, Bathgate RA, Ho BA, Bueno A, Hu X, Xiao J, Southall N, Barnaeva E, Agoulnik IU, Marugan JJ, Ferrer M, Agoulnik AI. Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290. Front Endocrinol (Lausanne). 2015; 6:128. PMID: 26347712.
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    9. Kaftanovskaya EM, Huang Z, Lopez C, Conrad K, Agoulnik AI. Conditional deletion of the relaxin receptor gene in cells of smooth muscle lineage affects lower reproductive tract in pregnant mice. Biol Reprod. 2015 Apr; 92(4):91. PMID: 25715795; PMCID: PMC4643956.
    10. Kaftanovskaya EM, Lopez C, Ferguson L, Myhr C, Agoulnik AI. Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis. FASEB J. 2015 Jun; 29(6):2327-37. PMID: 25713029.
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    11. Rivas B, Huang Z, Agoulnik AI. Normal fertility in male mice with deletion of ?-catenin gene in germ cells. Genesis. 2014 Apr; 52(4):328-32. PMID: 24443144.
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    12. Ferguson L, How JJ, Agoulnik AI. The fate of spermatogonial stem cells in the cryptorchid testes of RXFP2 deficient mice. PLoS One. 2013; 8(10):e77351. PMID: 24098584; PMCID: PMC3789668.
    13. Huang Z, Rivas B, Agoulnik AI. NOTCH1 gain of function in germ cells causes failure of spermatogenesis in male mice. PLoS One. 2013; 8(7):e71213. PMID: 23936265; PMCID: PMC3728026.
    14. Hodgson MC, Vanostran G, Alghamdi S, Poppiti RJ, Agoulnik AI, Agoulnik IU. Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice. PLoS One. 2013; 8(4):e60455. PMID: 23593223; PMCID: PMC3620158.
    15. Ferguson L, Agoulnik AI. Testicular cancer and cryptorchidism. Front Endocrinol (Lausanne). 2013; 4:32. PMID: 23519268; PMCID: PMC3602796.
    16. Kaftanovskaya EM, Neukirchner G, Huff V, Agoulnik AI. Left-sided cryptorchidism in mice with Wilms' tumour 1 gene deletion in gubernaculum testis. J Pathol. 2013 May; 230(1):39-47. PMID: 23288785; PMCID: PMC3819214.
    17. Xiao J, Huang Z, Chen CZ, Agoulnik IU, Southall N, Hu X, Jones RE, Ferrer M, Zheng W, Agoulnik AI, Marugan JJ. Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1. Nat Commun. 2013; 4:1953. PMID: 23764525.
      View in: PubMed
    18. Huang Z, Kaftanovskaya EM, Rivas B, Agoulnik AI. Mechanisms of INSL3 signaling in male reproductive organs. Ital J Anat Embryol. 2013; 118(1 Suppl):32-3. PMID: 24640567.
      View in: PubMed
    19. Huang Z, Rivas B, Agoulnik AI. Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice. Biol Reprod. 2012 Jun; 87(6):143. PMID: 23100620; PMCID: PMC4435430.
    20. Chen CZ, Southall N, Xiao J, Marugan JJ, Ferrer M, Hu X, Jones RE, Feng S, Agoulnik IU, Zheng W, Agoulnik AI. Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay. J Biomol Screen. 2013 Jul; 18(6):670-7. PMID: 23212924; PMCID: PMC4804196.
    21. Larson G, Karlsson EK, Perri A, Webster MT, Ho SY, Peters J, Stahl PW, Piper PJ, Lingaas F, Fredholm M, Comstock KE, Modiano JF, Schelling C, Agoulnik AI, Leegwater PA, Dobney K, Vigne JD, Vilà C, Andersson L, Lindblad-Toh K. Rethinking dog domestication by integrating genetics, archeology, and biogeography. Proc Natl Acad Sci U S A. 2012 Jun 5; 109(23):8878-83. PMID: 22615366; PMCID: PMC3384140.
    22. Kaftanovskaya EM, Huang Z, Barbara AM, De Gendt K, Verhoeven G, Gorlov IP, Agoulnik AI. Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testis. Mol Endocrinol. 2012 Apr; 26(4):598-607. PMID: 22322597; PMCID: PMC3327355.
    23. Agoulnik AI, Huang Z, Ferguson L. Spermatogenesis in cryptorchidism. Methods Mol Biol. 2012; 825:127-47. PMID: 22144242.
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    24. Segal MS, Sautina L, Li S, Diao Y, Agoulnik AI, Kielczewski J, McGuane JT, Grant MB, Conrad KP. Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice. Blood. 2012 Jan 12; 119(2):629-36. PMID: 22028476; PMCID: PMC3257020.
    25. Feng S, Agoulnik AI. Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis. Int J Oncol. 2011 Dec; 39(6):1559-65. PMID: 21842120.
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    26. Li Z, Feng S, Lopez V, Elhammady G, Anderson ML, Kaftanovskaya EM, Agoulnik AI. Uterine cysts in female mice deficient for caveolin-1 and insulin-like 3 receptor RXFP2. Endocrinology. 2011 Jun; 152(6):2474-82. PMID: 21467199; PMCID: PMC3100621.
    27. Kaftanovskaya EM, Feng S, Huang Z, Tan Y, Barbara AM, Kaur S, Truong A, Gorlov IP, Agoulnik AI. Suppression of insulin-like3 receptor reveals the role of ?-catenin and Notch signaling in gubernaculum development. Mol Endocrinol. 2011 Jan; 25(1):170-83. PMID: 21147849; PMCID: PMC3089031.
    28. Feng S, Agoulnik IU, Truong A, Li Z, Creighton CJ, Kaftanovskaya EM, Pereira R, Han HD, Lopez-Berestein G, Klonisch T, Ittmann MM, Sood AK, Agoulnik AI. Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis. Endocr Relat Cancer. 2010 Dec; 17(4):1021-33. PMID: 20861284.
      View in: PubMed
    29. Harris RM, Finlayson C, Weiss J, Fisher L, Hurley L, Barrett T, Emge D, Bathgate RA, Agoulnik AI, Jameson JL. A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism. Mamm Genome. 2010 Oct; 21(9-10):442-9. PMID: 20963592.
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    30. Hombach-Klonisch S, Bialek J, Radestock Y, Truong A, Agoulnik AI, Fiebig B, Willing C, Weber E, Hoang-Vu C, Klonisch T. INSL3 has tumor-promoting activity in thyroid cancer. Int J Cancer. 2010 Aug 1; 127(3):521-31. PMID: 19950223.
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    31. Feng S, Ferlin A, Truong A, Bathgate R, Wade JD, Corbett S, Han S, Tannour-Louet M, Lamb DJ, Foresta C, Agoulnik AI. INSL3/RXFP2 signaling in testicular descent. Ann N Y Acad Sci. 2009 Apr; 1160:197-204. PMID: 19416188; PMCID: PMC2970567.
    32. Li Z, Burzawa JK, Troung A, Feng S, Agoulnik IU, Tong X, Anderson ML, Kovanci E, Rajkovic A, Agoulnik AI. Relaxin signaling in uterine fibroids. Ann N Y Acad Sci. 2009 Apr; 1160:374-8. PMID: 19416222; PMCID: PMC2954601.
    33. Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Facciolli A, Morello R, Agoulnik AI, Foresta C. New roles for INSL3 in adults. Ann N Y Acad Sci. 2009 Apr; 1160:215-8. PMID: 19416191.
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    34. Feng S, Agoulnik IU, Li Z, Han HD, Lopez-Berestein G, Sood A, Ittmann MM, Agoulnik AI. Relaxin/RXFP1 signaling in prostate cancer progression. Ann N Y Acad Sci. 2009 Apr; 1160:379-80. PMID: 19416223; PMCID: PMC2945500.
    35. Pepe A, Ferlin A, Gianesello L, Facciolli A, Agoulnik AI, Foresta C. INSL3 plays a role in the balance between bone formation and resorption. Ann N Y Acad Sci. 2009 Apr; 1160:219-20. PMID: 19416192.
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    36. Yao L, Agoulnik AI, Cooke PS, Meling DD, Sherwood OD. Relative roles of the epithelial and stromal tissue compartment(s) in mediating the actions of relaxin and estrogen on cell proliferation and apoptosis in the mouse lower reproductive tract. Ann N Y Acad Sci. 2009 Apr; 1160:121-9. PMID: 19416172; PMCID: PMC2743517.
    37. Kietz S, Feng S, Agoulnik A, Hombach-Klonisch S. Estrogen and TCDD influence RLN2 gene activity in estrogen receptor-positive human breast cancer cells. Ann N Y Acad Sci. 2009 Apr; 1160:367-73. PMID: 19416221.
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    38. Ganesan A, Klonisch T, McGuane JT, Feng S, Agoulnik AI, Parry LJ. Normal prostate morphology in relaxin-mutant mice. Reprod Fertil Dev. 2009; 21(3):440-50. PMID: 19261221.
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    39. Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Giannini S, Zaccolo M, Facciolli A, Morello R, Agoulnik AI, Foresta C. Mutations in the insulin-like factor 3 receptor are associated with osteoporosis. J Bone Miner Res. 2008 May; 23(5):683-93. PMID: 18433302; PMCID: PMC2674542.
    40. Yao L, Agoulnik AI, Cooke PS, Meling DD, Sherwood OD. Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina. Endocrinology. 2008 May; 149(5):2072-9. PMID: 18218691; PMCID: PMC2329284.
    41. Feng S, Bogatcheva NV, Truong A, Korchin B, Bishop CE, Klonisch T, Agoulnik IU, Agoulnik AI. Developmental expression and gene regulation of insulin-like 3 receptor RXFP2 in mouse male reproductive organs. Biol Reprod. 2007 Oct; 77(4):671-80. PMID: 17615407.
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    42. El Houate B, Rouba H, Sibai H, Barakat A, Chafik A, Chadli el B, Imken L, Bogatcheva NV, Feng S, Agoulnik AI, McElreavey K. Novel mutations involving the INSL3 gene associated with cryptorchidism. J Urol. 2007 May; 177(5):1947-51. PMID: 17437853.
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    43. Feng S, Agoulnik IU, Bogatcheva NV, Kamat AA, Kwabi-Addo B, Li R, Ayala G, Ittmann MM, Agoulnik AI. Relaxin promotes prostate cancer progression. Clin Cancer Res. 2007 Mar 15; 13(6):1695-702. PMID: 17363522.
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    44. Agoulnik AI. Relaxin and related peptides in male reproduction. Adv Exp Med Biol. 2007; 612:49-64. PMID: 18161481.
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    45. Kern A, Agoulnik AI, Bryant-Greenwood GD. The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane. Endocrinology. 2007 Mar; 148(3):1181-94. PMID: 17158203.
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    46. Bogatcheva NV, Ferlin A, Feng S, Truong A, Gianesello L, Foresta C, Agoulnik AI. T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E138-44. PMID: 16926383.
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    47. Feng S, Bogatcheva NV, Truong A, Engel W, Adham IM, Agoulnik AI. Over expression of insulin-like 3 does not prevent cryptorchidism in GNRHR or HOXA10 deficient mice. J Urol. 2006 Jul; 176(1):399-404. PMID: 16753450.
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    48. Ferlin A, Bogatcheva NV, Gianesello L, Pepe A, Vinanzi C, Agoulnik AI, Foresta C. Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization. Mol Hum Reprod. 2006 Jun; 12(6):401-6. PMID: 16687567.
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    49. Kamat AA, Feng S, Agoulnik IU, Kheradmand F, Bogatcheva NV, Coffey D, Sood AK, Agoulnik AI. The role of relaxin in endometrial cancer. Cancer Biol Ther. 2006 Jan; 5(1):71-7. PMID: 16322684.
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    50. Feng S, Bogatcheva NV, Kamat AA, Truong A, Agoulnik AI. Endocrine effects of relaxin overexpression in mice. Endocrinology. 2006 Jan; 147(1):407-14. PMID: 16223865.
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    51. Agoulnik AI. Cryptorchidism--an estrogen spoil? J Clin Endocrinol Metab. 2005 Aug; 90(8):4975-7. PMID: 16087960.
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    52. Feng S, Bogatcheva NV, Kamat AA, Agoulnik AI. Genetic targeting of relaxin and insl3 signaling in mice. Ann N Y Acad Sci. 2005 May; 1041:82-90. PMID: 15956690.
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    53. Bogatcheva NV, Agoulnik AI. INSL3/LGR8 role in testicular descent and cryptorchidism. Reprod Biomed Online. 2005 Jan; 10(1):49-54. PMID: 15705294.
      View in: PubMed
    54. Kamat AA, Younes PS, Sayeeduddin M, Wheeler TM, Simpson JL, Agoulnik AI. Protein expression profiling of endometriosis: validation of 2-mm tissue microarrays. Fertil Steril. 2004 Dec; 82(6):1681-3. PMID: 15589880.
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    55. Feng S, Cortessis VK, Hwang A, Hardy B, Koh CJ, Bogatcheva NV, Agoulnik AI. Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism. Urology. 2004 Nov; 64(5):1032-6. PMID: 15533513.
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    56. Adham IM, Agoulnik AI. Insulin-like 3 signalling in testicular descent. Int J Androl. 2004 Oct; 27(5):257-65. PMID: 15379965.
      View in: PubMed
    57. Kamat AA, Feng S, Bogatcheva NV, Truong A, Bishop CE, Agoulnik AI. Genetic targeting of relaxin and insulin-like factor 3 receptors in mice. Endocrinology. 2004 Oct; 145(10):4712-20. PMID: 15256493.
      View in: PubMed
    58. Tomiyama H, Hutson JM, Truong A, Agoulnik AI. Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor. J Pediatr Surg. 2003 Dec; 38(12):1793-8. PMID: 14666470.
      View in: PubMed
    59. Bogatcheva NV, Truong A, Feng S, Engel W, Adham IM, Agoulnik AI. GREAT/LGR8 is the only receptor for insulin-like 3 peptide. Mol Endocrinol. 2003 Dec; 17(12):2639-46. PMID: 12933905.
      View in: PubMed
    60. Truong A, Bogatcheva NV, Schelling C, Dolf G, Agoulnik AI. Isolation and expression analysis of the canine insulin-like factor 3 gene. Biol Reprod. 2003 Nov; 69(5):1658-64. PMID: 12890727.
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    61. Qin Y, Poirier C, Truong C, Schumacher A, Agoulnik AI, Bishop CE. A major locus on mouse chromosome 18 controls XX sex reversal in Odd Sex (Ods) mice. Hum Mol Genet. 2003 Mar 1; 12(5):509-15. PMID: 12588798.
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    62. Agoulnik AI, Lu B, Zhu Q, Truong C, Ty MT, Arango N, Chada KK, Bishop CE. A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd. Hum Mol Genet. 2002 Nov 15; 11(24):3047-53. PMID: 12417526.
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    63. Gorlov IP, Kamat A, Bogatcheva NV, Jones E, Lamb DJ, Truong A, Bishop CE, McElreavey K, Agoulnik AI. Mutations of the GREAT gene cause cryptorchidism. Hum Mol Genet. 2002 Sep 15; 11(19):2309-18. PMID: 12217959.
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    64. Rohozinski J, Agoulnik AI, Boettger-Tong HL, Bishop CE. Successful targeting of mouse Y chromosome genes using a site-directed insertion vector. Genesis. 2002 Jan; 32(1):1-7. PMID: 11835668.
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    65. Sers C, Tchernitsa OI, Zuber J, Diatchenko L, Zhumabayeva B, Desai S, Htun S, Hyder K, Wiechen K, Agoulnik A, Scharff KM, Siebert PD, Schäfer R. Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays. Adv Enzyme Regul. 2002; 42:63-82. PMID: 12123707.
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    66. Boettger-Tong HL, Rohozinski J, Agoulnik AI, Dohmae K, Nishimune Y, Levy N, Bishop CE. Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes. Biochem Biophys Res Commun. 2001 Nov 16; 288(5):1129-35. PMID: 11700028.
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    67. Wiechen K, Diatchenko L, Agoulnik A, Scharff KM, Schober H, Arlt K, Zhumabayeva B, Siebert PD, Dietel M, Schäfer R, Sers C. Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. Am J Pathol. 2001 Nov; 159(5):1635-43. PMID: 11696424; PMCID: PMC1867061.
    68. Overbeek PA, Gorlov IP, Sutherland RW, Houston JB, Harrison WR, Boettger-Tong HL, Bishop CE, Agoulnik AI. A transgenic insertion causing cryptorchidism in mice. Genesis. 2001 May; 30(1):26-35. PMID: 11353515.
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    69. Wiechen K, Sers C, Agoulnik A, Arlt K, Dietel M, Schlag PM, Schneider U. Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas. Am J Pathol. 2001 Mar; 158(3):833-9. PMID: 11238032; PMCID: PMC1850346.
    70. Bishop CE, Whitworth DJ, Qin Y, Agoulnik AI, Agoulnik IU, Harrison WR, Behringer RR, Overbeek PA. A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse. Nat Genet. 2000 Dec; 26(4):490-4. PMID: 11101852.
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    71. Lévy N, Boettger-Tong H, Dohmae K, Agoulnik AI, Ty TI, Nishimune Y, Bishop CE. Physical and genetic linkage of glutaminase (Gls), signal transducer and activator of transcription 1 (Stat1), and xeroderma pigmentosum complementation group G (Xpg) on mouse proximal chromosome 1. Genomics. 1998 Dec 1; 54(2):355-6. PMID: 9828143.
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