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DEREK THEODOOR BOERBOOM

TitleAdjunct Instructor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
AddressMOLECULAR & CELLULAR BIOLOGY
ONE BAYLOR PLAZA
HOUSTON TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Feng Y, Cui P, Lu X, Hsueh B, Möller Billig F, Zarnescu Yanez L, Tomer R, Boerboom D, Carmeliet P, Deisseroth K, Hsueh AJ. CLARITY reveals dynamics of ovarian follicular architecture and vasculature in three-dimensions. Sci Rep. 2017 Mar 23; 7:44810. PMID: 28333125.
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    2. Boyer A, Girard M, Thimmanahalli DS, Levasseur A, Céleste C, Paquet M, Duggavathi R, Boerboom D. mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice. Biol Reprod. 2016 Jul; 95(1):13. PMID: 27281705.
      View in: PubMed
    3. Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D'Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H. Motif mimetic of epsin perturbs tumor growth and metastasis. J Clin Invest. 2016 Apr 1; 126(4):1607. PMID: 26999611; PMCID: PMC4811111.
    4. Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, Hayashi K, Honda H, Kikuchi A, Price C, Boerboom D. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB J. 2016 Apr; 30(4):1534-47. PMID: 26667040; PMCID: PMC4799500 [Available on 04/01/17].
    5. Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D'Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H. Motif mimetic of epsin perturbs tumor growth and metastasis. J Clin Invest. 2015 Dec; 125(12):4349-64. PMID: 26571402.
      View in: PubMed
    6. Nadeau MÈ, Rico C, Tsoi M, Vivancos M, Filimon S, Paquet M, Boerboom D. Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells. BMC Cancer. 2015; 15:479. PMID: 26104798.
      View in: PubMed
    7. Abedini A, Zamberlam G, Boerboom D, Price CA. Non-canonical WNT5A is a potential regulator of granulosa cell function in cattle. Mol Cell Endocrinol. 2015 Mar 5; 403:39-45. PMID: 25600632.
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    8. Boerboom D, Kumar V, Boyer A, Wang Y, Lambrot R, Zhou X, Rico C, Boehm U, Paquet M, Céleste C, Kimmins S, Bernard DJ. ?-catenin stabilization in gonadotropes impairs FSH synthesis in male mice in vivo. Endocrinology. 2015 Jan; 156(1):323-33. PMID: 25343272; PMCID: PMC4272392.
    9. Rico C, Dodelet-Devillers A, Paquet M, Tsoi M, Lapointe E, Carmeliet P, Boerboom D. HIF1 activity in granulosa cells is required for FSH-regulated Vegfa expression and follicle survival in mice. Biol Reprod. 2014 Jun; 90(6):135. PMID: 24855100.
      View in: PubMed
    10. Tsoi M, Laguë MN, Boyer A, Paquet M, Nadeau MÈ, Boerboom D. Anti-VEGFA Therapy Reduces Tumor Growth and Extends Survival in a Murine Model of Ovarian Granulosa Cell Tumor. Transl Oncol. 2013 Jun; 6(3):226-33. PMID: 23730402; PMCID: PMC3660791.
    11. Fortin J, Kumar V, Zhou X, Wang Y, Auwerx J, Schoonjans K, Boehm U, Boerboom D, Bernard DJ. NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo. PLoS One. 2013; 8(3):e59058. PMID: 23536856; PMCID: PMC3594184.
    12. Tran S, Zhou X, Lafleur C, Calderon MJ, Ellsworth BS, Kimmins S, Boehm U, Treier M, Boerboom D, Bernard DJ. Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice. Mol Endocrinol. 2013 Mar; 27(3):407-21. PMID: 23340250; PMCID: PMC3589670.
    13. Lapointe E, Boyer A, Rico C, Paquet M, Franco HL, Gossen J, DeMayo FJ, Richards JS, Boerboom D. FZD1 regulates cumulus expansion genes and is required for normal female fertility in mice. Biol Reprod. 2012 Nov; 87(5):104. PMID: 22954793; PMCID: PMC3509776.
    14. Rico C, Laguë MN, Lefèvre P, Tsoi M, Dodelet-Devillers A, Kumar V, Lapointe E, Paquet M, Nadeau MÈ, Boerboom D. Pharmacological targeting of mammalian target of rapamycin inhibits ovarian granulosa cell tumor growth. Carcinogenesis. 2012 Nov; 33(11):2283-92. PMID: 22871496.
      View in: PubMed
    15. Laguë MN, Romieu-Mourez R, Bonneil É, Boyer A, Pouletty N, Mes-Masson AM, Thibault P, Nadeau MÈ, Boerboom D. Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human cancers. PLoS One. 2012; 7(8):e42470. PMID: 22870330; PMCID: PMC3411637.
    16. Boyer A, Yeh JR, Zhang X, Paquet M, Gaudin A, Nagano MC, Boerboom D. CTNNB1 signaling in sertoli cells downregulates spermatogonial stem cell activity via WNT4. PLoS One. 2012; 7(1):e29764. PMID: 22253774; PMCID: PMC3257228.
    17. Deschene K, Céleste C, Boerboom D, Theoret CL. Hypoxia regulates the expression of extracellular matrix associated proteins in equine dermal fibroblasts via HIF1. J Dermatol Sci. 2012 Jan; 65(1):12-8. PMID: 21999945.
      View in: PubMed
    18. Richards JS, Fan HY, Liu Z, Tsoi M, Laguë MN, Boyer A, Boerboom D. Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22; 31(12):1504-20. PMID: 21860425; PMCID: PMC3223552.
    19. Paquet M, El-Warrak AO, Laguë MN, Boerboom D. Atypical caudal duplication with phenotypic sex reversal in a dog. J Vet Diagn Invest. 2011 Sep; 23(5):1037-40. PMID: 21908371.
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    20. Boerboom D, Lafond JF, Zheng X, Lapointe E, Mittaz L, Boyer A, Pritchard MA, DeMayo FJ, Mort JS, Drolet R, Richards JS. Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Dev Dyn. 2011 Jul; 240(7):1806-14. PMID: 21584905; PMCID: PMC3116038.
    21. Deschene K, Céleste C, Boerboom D, Theoret CL. Constitutive expression of hypoxia-inducible factor-1 ? in keratinocytes during the repair of skin wounds in horses. Wound Repair Regen. 2011 Mar-Apr; 19(2):250-9. PMID: 21362093.
      View in: PubMed
    22. Lapointe E, Boerboom D. WNT signaling and the regulation of ovarian steroidogenesis. Front Biosci (Schol Ed). 2011; 3:276-85. PMID: 21196376.
      View in: PubMed
    23. Franco HL, Dai D, Lee KY, Rubel CA, Roop D, Boerboom D, Jeong JW, Lydon JP, Bagchi IC, Bagchi MK, DeMayo FJ. WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse. FASEB J. 2011 Apr; 25(4):1176-87. PMID: 21163860; PMCID: PMC3058697.
    24. Laguë MN, Detmar J, Paquet M, Boyer A, Richards JS, Adamson SL, Boerboom D. Decidual PTEN expression is required for trophoblast invasion in the mouse. Am J Physiol Endocrinol Metab. 2010 Dec; 299(6):E936-46. PMID: 20858757; PMCID: PMC3006249.
    25. Brown HM, Dunning KR, Robker RL, Boerboom D, Pritchard M, Lane M, Russell DL. ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice. Biol Reprod. 2010 Oct; 83(4):549-57. PMID: 20592310.
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    26. Boyer A, Lapointe E, Zheng X, Cowan RG, Li H, Quirk SM, DeMayo FJ, Richards JS, Boerboom D. WNT4 is required for normal ovarian follicle development and female fertility. FASEB J. 2010 Aug; 24(8):3010-25. PMID: 20371632; PMCID: PMC2909279.
    27. Nadeau ME, Kaartinen MJ, Laguë MN, Paquet M, Huneault LM, Boerboom D. A mouse surgical model for metastatic ovarian granulosa cell tumor. Comp Med. 2009 Dec; 59(6):553-6. PMID: 20034430; PMCID: PMC2798836.
    28. Boyer A, Goff AK, Boerboom D. WNT signaling in ovarian follicle biology and tumorigenesis. Trends Endocrinol Metab. 2010 Jan; 21(1):25-32. PMID: 19875303.
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    29. Buczinski S, Rezakhani A, Boerboom D. Heart disease in cattle: diagnosis, therapeutic approaches and prognosis. Vet J. 2010 Jun; 184(3):258-63. PMID: 19734077.
      View in: PubMed
    30. Zheng X, Boerboom D, Carrière PD. Transforming growth factor-beta1 inhibits luteinization and promotes apoptosis in bovine granulosa cells. Reproduction. 2009 Jun; 137(6):969-77. PMID: 19307427.
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    31. Boyer A, Paquet M, Laguë MN, Hermo L, Boerboom D. Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis. Carcinogenesis. 2009 May; 30(5):869-78. PMID: 19237610; PMCID: PMC2675650.
    32. Laguë MN, Paquet M, Fan HY, Kaartinen MJ, Chu S, Jamin SP, Behringer RR, Fuller PJ, Mitchell A, Doré M, Huneault LM, Richards JS, Boerboom D. Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. Carcinogenesis. 2008 Nov; 29(11):2062-72. PMID: 18687666; PMCID: PMC2577137.
    33. Paquet M, Penney J, Boerboom D. Lateral femoral hernias in a line of FVB/NHsd mice: a new confounding lesion linked to genetic background? Comp Med. 2008 Aug; 58(4):395-8. PMID: 18724783; PMCID: PMC2706040.
    34. Boyer A, Hermo L, Paquet M, Robaire B, Boerboom D. Seminiferous tubule degeneration and infertility in mice with sustained activation of WNT/CTNNB1 signaling in sertoli cells. Biol Reprod. 2008 Sep; 79(3):475-85. PMID: 18480464.
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    35. Brown KA, Boerboom D, Bouchard N, Doré M, Lussier JG, Sirois J. Human chorionic gonadotropin-dependent induction of an equine aldo-keto reductase (AKR1C23) with 20alpha-hydroxysteroid dehydrogenase activity during follicular luteinization in vivo. J Mol Endocrinol. 2006 Jun; 36(3):449-61. PMID: 16720716.
      View in: PubMed
    36. Boerboom D, White LD, Dalle S, Courty J, Richards JS. Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model. Cancer Res. 2006 Feb 15; 66(4):1964-73. PMID: 16488995.
      View in: PubMed
    37. Boerboom D, Paquet M, Hsieh M, Liu J, Jamin SP, Behringer RR, Sirois J, Taketo MM, Richards JS. Misregulated Wnt/beta-catenin signaling leads to ovarian granulosa cell tumor development. Cancer Res. 2005 Oct 15; 65(20):9206-15. PMID: 16230381.
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    38. Hsieh M, Boerboom D, Shimada M, Lo Y, Parlow AF, Luhmann UF, Berger W, Richards JS. Mice null for Frizzled4 (Fzd4-/-) are infertile and exhibit impaired corpora lutea formation and function. Biol Reprod. 2005 Dec; 73(6):1135-46. PMID: 16093361.
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    39. Richards JS, Hernandez-Gonzalez I, Gonzalez-Robayna I, Teuling E, Lo Y, Boerboom D, Falender AE, Doyle KH, LeBaron RG, Thompson V, Sandy JD. Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod. 2005 May; 72(5):1241-55. PMID: 15659705.
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    40. Sayasith K, Bouchard N, Boerboom D, Brown KA, Doré M, Sirois J. Molecular characterization of equine P-selectin (CD62P) and its regulation in ovarian follicles during the ovulatory process. Biol Reprod. 2005 Mar; 72(3):736-44. PMID: 15564599.
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    41. Brown KA, Boerboom D, Bouchard N, Doré M, Lussier JG, Sirois J. Human chorionic gonadotropin-dependent regulation of 17beta-hydroxysteroid dehydrogenase type 4 in preovulatory follicles and its potential role in follicular luteinization. Endocrinology. 2004 Apr; 145(4):1906-15. PMID: 14726434.
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    42. Boerboom D, Russell DL, Richards JS, Sirois J. Regulation of transcripts encoding ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin-like motifs-1) and progesterone receptor by human chorionic gonadotropin in equine preovulatory follicles. J Mol Endocrinol. 2003 Dec; 31(3):473-85. PMID: 14664708.
      View in: PubMed
    43. Boerboom D, Mulon PY, Desrochers A. Duodenal obstruction caused by malposition of the gallbladder in a heifer. J Am Vet Med Assoc. 2003 Nov 15; 223(10):1475-7, 1435. PMID: 14627100.
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    44. Boerboom D, Brown KA, Vaillancourt D, Poitras P, Goff AK, Watanabe K, Doré M, Sirois J. Expression of key prostaglandin synthases in equine endometrium during late diestrus and early pregnancy. Biol Reprod. 2004 Feb; 70(2):391-9. PMID: 14561653.
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    45. Boutemmine D, Bouchard N, Boerboom D, Jones HE, Goff AK, Doré M, Sirois J. Molecular characterization of canine prostaglandin G/H synthase-2 and regulation in prostatic adenocarcinoma cells in vitro. Endocrinology. 2002 Mar; 143(3):1134-43. PMID: 11861541.
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    46. Boutemmine D, Bouchard N, Boerboom D, Jones HE, Goff AK, Dore M, Sirois J. Molecular Characterization of Canine Prostaglandin G/H Synthase-2 and Regulation in Prostatic Adenocarcinoma Cells in Vitro. Endocrinology. 2002 Mar 01; 143(3):1134-1143. PMID: 28201358.
      View in: PubMed
    47. Liu J, Antaya M, Goff AK, Boerboom D, Silversides DW, Lussier JG, Sirois J. Molecular characterization of bovine prostaglandin G/H synthase-2 and regulation in uterine stromal cells. Biol Reprod. 2001 Mar; 64(3):983-91. PMID: 11207216.
      View in: PubMed
    48. Boerboom D, Sirois J. Equine P450 cholesterol side-chain cleavage and 3 beta-hydroxysteroid dehydrogenase/delta(5)-delta(4) isomerase: molecular cloning and regulation of their messenger ribonucleic acids in equine follicles during the ovulatory process. Biol Reprod. 2001 Jan; 64(1):206-15. PMID: 11133676.
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    49. Boerboom D, Pilon N, Behdjani R, Silversides DW, Sirois J. Expression and regulation of transcripts encoding two members of the NR5A nuclear receptor subfamily of orphan nuclear receptors, steroidogenic factor-1 and NR5A2, in equine ovarian cells during the ovulatory process. Endocrinology. 2000 Dec; 141(12):4647-56. PMID: 11108279.
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    50. Boerboom D, Pilon N, Behdjani R, Silversides DW, Sirois J. Expression and Regulation of Transcripts Encoding Two Members of the NR5A Nuclear Receptor Subfamily of Orphan Nuclear Receptors, Steroidogenic Factor-1 and NR5A2, in Equine Ovarian Cells during the Ovulatory Process* *This study was supported by Natural Sciences and Engineering Research Council of Canada Grant OPG0171135. The nucleotide sequences reported in this paper have been submitted to GenBank, with accession numbers AF157626, AF168796, AF203911, and AF203913. Endocrinology. 2000 Dec 01; 141(12):4647-4656. PMID: 28204327.
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    51. Liu J, Antaya M, Boerboom D, Lussier JG, Silversides DW, Sirois J. The delayed activation of the prostaglandin G/H synthase-2 promoter in bovine granulosa cells is associated with down-regulation of truncated upstream stimulatory factor-2. J Biol Chem. 1999 Dec 3; 274(49):35037-45. PMID: 10574982.
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    52. Boerboom D, Kerban A, Sirois J. Dual regulation of promoter II- and promoter 1f-derived cytochrome P450 aromatase transcripts in equine granulosa cells during human chorionic gonadotropin-induced ovulation: a novel model for the study of aromatase promoter switching. Endocrinology. 1999 Sep; 140(9):4133-41. PMID: 10465286.
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    53. Boerboom D, Kerban A, Sirois J. Dual Regulation of Promoter II- and Promoter 1f-Derived Cytochrome P450 Aromatase Transcripts in Equine Granulosa Cells during Human Chorionic Gonadotropin-Induced Ovulation: A Novel Model for the Study of Aromatase Promoter Switching1. Endocrinology. 1999 Sep 01; 140(9):4133-4141. PMID: 28201009.
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    54. Kerban A, Boerboom D, Sirois J. Human chorionic gonadotropin induces an inverse regulation of steroidogenic acute regulatory protein messenger ribonucleic acid in theca interna and granulosa cells of equine preovulatory follicles. Endocrinology. 1999 Feb; 140(2):667-74. PMID: 9927292.
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    55. Boerboom D, Sirois J. Molecular characterization of equine prostaglandin G/H synthase-2 and regulation of its messenger ribonucleic acid in preovulatory follicles. Endocrinology. 1998 Apr; 139(4):1662-70. PMID: 9528947.
      View in: PubMed
    56. Wagner J, Boerboom D, Tremblay ML. Molecular cloning and tissue-specific RNA processing of a murine receptor-type protein tyrosine phosphatase. Eur J Biochem. 1994 Dec 15; 226(3):773-82. PMID: 7529177.
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    57. Tillmann U, Wagner J, Boerboom D, Westphal H, Tremblay ML. Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase. Mol Cell Biol. 1994 May; 14(5):3030-40. PMID: 8164659; PMCID: PMC358671.
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