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KE-HE RUAN

TitleProfessor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
Address552 Science and Research Building 2
Houston TX 77204-5037
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Akasaka H, Thaliachery N, Zheng X, Blumenthal M, Nikhar S, Murdoch EE, Ling Q, Ruan KH. The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE2-and retaining PGE1-mediated signaling in live cells. Arch Biochem Biophys. 2017 Jan 05. PMID: 28065721.
      View in: PubMed
    2. Ling QL, Murdoch E, Ruan KH. How can we address the controversies surrounding the use of NSAIDS in neurodegeneration? Future Med Chem. 2016 Jul; 8(11):1153-5. PMID: 27357618.
      View in: PubMed
    3. Akasaka H, Ruan KH. How can we target oxidative stress in the treatment of neurodegenerative diseases? Future Med Chem. 2016 May; 8(8):835-9. PMID: 27173453.
      View in: PubMed
    4. Akasaka H, Ruan KH. Identification of the two-phase mechanism of arachidonic acid regulating inflammatory prostaglandin E2 biosynthesis by targeting COX-2 and mPGES-1. Arch Biochem Biophys. 2016 Aug 1; 603:29-37. PMID: 27177970.
      View in: PubMed
    5. Akasaka H, So SP, Ruan KH. Relationship of the Topological Distances and Activities between mPGES-1 and COX-2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX-1 and COX-2. Biochemistry. 2015 Jun 16; 54(23):3707-15. PMID: 25988363.
      View in: PubMed
    6. Zhu Y, Cong W, Shen L, Wei H, Wang Y, Wang L, Ruan K, Wu F, Feng Y. Fecal metabonomic study of a polysaccharide, MDG-1 from Ophiopogon japonicus on diabetic mice based on gas chromatography/time-of-flight mass spectrometry (GC TOF/MS). Mol Biosyst. 2014 Feb; 10(2):304-12. PMID: 24292023.
      View in: PubMed
    7. Vollert C, Ohia O, Akasaka H, Berridge C, Ruan KH, Eriksen JL. Elevated prostacyclin biosynthesis in mice impacts memory and anxiety-like behavior. Behav Brain Res. 2014 Jan 1; 258:138-44. PMID: 24140503; PMCID: PMC3849419.
    8. Liu CL, Ruan KF, Gao JW, Wu F, Zhang JQ. [Multiple mechanisms of depression]. Sheng Li Ke Xue Jin Zhan. 2013 Aug; 44(4):253-8. PMID: 24228515.
      View in: PubMed
    9. Zhou L, Chen Z, Vanderslice P, So SP, Ruan KH, Willerson JT, Dixon RA. Endothelial-like progenitor cells engineered to produce prostacyclin rescue monocrotaline-induced pulmonary arterial hypertension and provide right ventricle benefits. Circulation. 2013 Aug 27; 128(9):982-94. PMID: 23841984.
      View in: PubMed
    10. Ruan KH, Mohite AJ, So SP. Resistant to thrombosis, induced stroke and heart arrest by incorporation of a single gene of PGI2-synthesizing COX-1-PGIS in vivo: Implication against human heart disease. Int J Cardiol. 2013 Oct 3; 168(3):2960-1. PMID: 23602873.
      View in: PubMed
    11. Lin H, Yuan J, Ruan KH, Yang W, Zhang J, Dai Y, Wang R. COX-2-10aa-PGIS gene therapy improves erectile function in rats after cavernous nerve injury. J Sex Med. 2013 Jun; 10(6):1476-87. PMID: 23551902.
      View in: PubMed
    12. Liu Q, Xi Y, Terry T, So SP, Mohite A, Zhang J, Wu G, Liu X, Cheng J, Ruan KH, Willerson JT, Dixon RA. Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells. J Cell Physiol. 2012 Jul; 227(7):2907-16. PMID: 21938725; PMCID: PMC3292628.
    13. Chen Y, Fujita T, Zhang D, Doan H, Pinkaew D, Liu Z, Wu J, Koide Y, Chiu A, Lin CC, Chang JY, Ruan KH, Fujise K. Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein. J Biol Chem. 2011 Sep 16; 286(37):32575-85. PMID: 21795694; PMCID: PMC3173145.
    14. Ruan KH, Mohite A, So SP, Ruan CH. Establishing novel prostacyclin-synthesizing cells with therapeutic potential against heart diseases. Int J Cardiol. 2013 Feb 20; 163(2):163-9. PMID: 21722977.
      View in: PubMed
    15. Mohite A, Chillar A, So SP, Cervantes V, Ruan KH. Novel mechanism of the vascular protector prostacyclin: regulating microRNA expression. Biochemistry. 2011 Mar 15; 50(10):1691-9. PMID: 21250659.
      View in: PubMed
    16. Chillar AJ, Karimi P, Tang K, Ruan KH. An agonist sensitive, quick and simple cell-based signaling assay for determination of ligands mimicking prostaglandin E2 or E1 activity through subtype EP1 receptor: Suitable for high throughput screening. BMC Complement Altern Med. 2011; 11:11. PMID: 21299883; PMCID: PMC3042985.
    17. Ruan CH, So SP, Ruan KH. Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: mechanisms of COX-2 inhibitor risk to heart disease. Life Sci. 2011 Jan 3; 88(1-2):24-30. PMID: 21035466; PMCID: PMC3046773.
    18. Chillar A, Wu J, Cervantes V, Ruan KH. Structural and functional analysis of the C-terminus of Galphaq in complex with the human thromboxane A2 receptor provides evidence of constitutive activity. Biochemistry. 2010 Aug 3; 49(30):6365-74. PMID: 20590159.
      View in: PubMed
    19. Chillar A, So SP, Ruan CH, Shelat H, Geng YJ, Ruan KH. A profile of NSAID-targeted arachidonic acid metabolisms in human embryonic stem cells (hESCs): implication of the negative effects of NSAIDs on heart tissue regeneration. Int J Cardiol. 2011 Aug 4; 150(3):253-9. PMID: 20451268.
      View in: PubMed
    20. Ruan CH, Dixon RA, Willerson JT, Ruan KH. Prostacyclin therapy for pulmonary arterial hypertension. Tex Heart Inst J. 2010; 37(4):391-9. PMID: 20844610; PMCID: PMC2929860.
    21. Ruan KH, Cervantes V, So SP. Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2. Protein Eng Des Sel. 2009 Dec; 22(12):733-40. PMID: 19850676; PMCID: PMC2777022.
    22. Ruan KH, Cervantes V, Wu J. Ligand-specific conformation determines agonist activation and antagonist blockade in purified human thromboxane A2 receptor. Biochemistry. 2009 Apr 14; 48(14):3157-65. PMID: 19170518.
      View in: PubMed
    23. Yuan J, Westney OL, Ruan KH, Wang R. A new strategy, SuperEnzyme gene therapy in penile rehabilitation. J Sex Med. 2009 Mar; 6 Suppl 3:328-33. PMID: 19267856.
      View in: PubMed
    24. Ruan KH, So SP, Cervantes V, Wu H, Wijaya C, Jentzen RR. An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector. FEBS J. 2008 Dec; 275(23):5820-9. PMID: 19021758; PMCID: PMC3038792.
    25. Ruan KH, So SP, Wu H, Cervantes V. Large-scale expression, purification, and characterization of an engineered prostacyclin-synthesizing enzyme with therapeutic potential. Arch Biochem Biophys. 2008 Dec 1; 480(1):41-50. PMID: 18835243; PMCID: PMC2717720.
    26. Chillar A, Wu J, So SP, Ruan KH. Involvement of non-conserved residues important for PGE2 binding to the constrained EP3 eLP2 using NMR and site-directed mutagenesis. FEBS Lett. 2008 Aug 20; 582(19):2863-8. PMID: 18652829; PMCID: PMC2677024.
    27. Ruan KH, Wijaya C, Cervantes V, Wu J. Characterization of the prostaglandin H2 mimic: binding to the purified human thromboxane A2 receptor in solution. Arch Biochem Biophys. 2008 Sep 15; 477(2):396-403. PMID: 18590695; PMCID: PMC2572108.
    28. Ruan KH, Cervantes V, Wu J. A simple, quick, and high-yield preparation of the human thromboxane A2 receptor in full size for structural studies. Biochemistry. 2008 Jul 1; 47(26):6819-26. PMID: 18529068; PMCID: PMC2581465.
    29. Ruan KH, Wu J, Cervantes V. Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin. Biochemistry. 2008 Jan 15; 47(2):680-8. PMID: 18081314.
      View in: PubMed
    30. Wu J, Feng M, Ruan KH. Assembling NMR structures for the intracellular loops of the human thromboxane A2 receptor: implication of the G protein-coupling pocket. Arch Biochem Biophys. 2008 Feb 1; 470(1):73-82. PMID: 18073117; PMCID: PMC2295216.
    31. Ni F, So SP, Cervantes V, Ruan KH. A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor. FEBS J. 2008 Jan; 275(1):128-37. PMID: 18042246; PMCID: PMC3046732.
    32. Ruan KH, Deng H, So SP. Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin. Biochemistry. 2006 Nov 28; 45(47):14003-11. PMID: 17115695.
      View in: PubMed
    33. Zhang L, Bastepe M, Jüppner H, Ruan KH. Characterization of the molecular mechanisms of the coupling between intracellular loops of prostacyclin receptor with the C-terminal domain of the Galphas protein in human coronary artery smooth muscle cells. Arch Biochem Biophys. 2006 Oct 1; 454(1):80-8. PMID: 16942748.
      View in: PubMed
    34. Huang JC, Ruan CH, Tang K, Ruan KH. Prunella stica inhibits the proliferation but not the prostaglandin production of Ishikawa cells. Life Sci. 2006 Jun 27; 79(5):436-41. PMID: 16481008.
      View in: PubMed
    35. Zhang L, Wu J, Ruan KH. Solution structure of the first intracellular loop of prostacyclin receptor and implication of its interaction with the C-terminal segment of G alpha s protein. Biochemistry. 2006 Feb 14; 45(6):1734-44. PMID: 16460020.
      View in: PubMed
    36. Ruan KH, Dogné JM. Implications of the molecular basis of prostacyclin biosynthesis and signaling in pharmaceutical designs. Curr Pharm Des. 2006; 12(8):925-41. PMID: 16533160.
      View in: PubMed
    37. Ruan CH, Wu J, Ruan KH. A strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor. BMC Biochem. 2005; 6:23. PMID: 16271145; PMCID: PMC1298286.
    38. Ruan KH, Wu J, Wang LH. Solution structure of a common substrate mimetic of cyclooxygenase-downstream synthases bound to an engineered thromboxane A2 synthase using a high-resolution NMR technique. Arch Biochem Biophys. 2005 Dec 15; 444(2):165-73. PMID: 16297851.
      View in: PubMed
    39. Zhang L, Huang G, Wu J, Ruan KH. A profile of the residues in the first intracellular loop critical for Gs-mediated signaling of human prostacyclin receptor characterized by an integrative approach of NMR-experiment and mutagenesis. Biochemistry. 2005 Aug 30; 44(34):11389-401. PMID: 16114876.
      View in: PubMed
    40. Ruan KH, Deng H, Wu J, So SP. The N-terminal membrane anchor domain of the membrane-bound prostacyclin synthase involved in the substrate presentation of the coupling reaction with cyclooxygenase. Arch Biochem Biophys. 2005 Mar 15; 435(2):372-81. PMID: 15708381.
      View in: PubMed
    41. Ruan KH. Advance in understanding the biosynthesis of prostacyclin and thromboxane A2 in the endoplasmic reticulum membrane via the cyclooxygenase pathway. Mini Rev Med Chem. 2004 Aug; 4(6):639-47. PMID: 15279598.
      View in: PubMed
    42. Ruan KH, Wu J, So SP, Jenkins LA, Ruan CH. NMR structure of the thromboxane A2 receptor ligand recognition pocket. Eur J Biochem. 2004 Jul; 271(14):3006-16. PMID: 15233797.
      View in: PubMed
    43. Dogné JM, de Leval X, Hanson J, Frederich M, Lambermont B, Ghuysen A, Casini A, Masereel B, Ruan KH, Pirotte B, Kolh P. New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators. Curr Med Chem. 2004 May; 11(10):1223-41. PMID: 15134516.
      View in: PubMed
    44. Geng L, Wu J, So SP, Huang G, Ruan KH. Structural and functional characterization of the first intracellular loop of human thromboxane A2 receptor. Arch Biochem Biophys. 2004 Mar 15; 423(2):253-65. PMID: 15001390.
      View in: PubMed
    45. Ruan KH, Wu J, So SP, Jenkins LA. Evidence of the residues involved in ligand recognition in the second extracellular loop of the prostacyclin receptor characterized by high resolution 2D NMR techniques. Arch Biochem Biophys. 2003 Oct 1; 418(1):25-33. PMID: 13679079.
      View in: PubMed
    46. Wu J, So SP, Ruan KH. Solution structure of the third extracellular loop of human thromboxane A2 receptor. Arch Biochem Biophys. 2003 Jun 15; 414(2):287-93. PMID: 12781781.
      View in: PubMed
    47. Deng H, Wu J, So SP, Ruan KH. Identification of the residues in the helix F/G loop important to catalytic function of membrane-bound prostacyclin synthase. Biochemistry. 2003 May 20; 42(19):5609-17. PMID: 12741817.
      View in: PubMed
    48. Wu J, So SP, Ruan KH. Determination of the membrane contact residues and solution structure of the helix F/G loop of prostaglandin I2 synthase. Arch Biochem Biophys. 2003 Mar 1; 411(1):27-35. PMID: 12590920.
      View in: PubMed
    49. So SP, Wu J, Huang G, Huang A, Li D, Ruan KH. Identification of residues important for ligand binding of thromboxane A2 receptor in the second extracellular loop using the NMR experiment-guided mutagenesis approach. J Biol Chem. 2003 Mar 28; 278(13):10922-7. PMID: 12551898.
      View in: PubMed
    50. Ruan KH, So SP, Zheng W, Wu J, Li D, Kung J. Solution structure and topology of the N-terminal membrane anchor domain of a microsomal cytochrome P450: prostaglandin I2 synthase. Biochem J. 2002 Dec 15; 368(Pt 3):721-8. PMID: 12193162; PMCID: PMC1223024.
    51. Arbab F, Goldsby J, Matijevic-Aleksic N, Huang G, Ruan KH, Huang JC. Prostacyclin is an autocrine regulator in the contraction of oviductal smooth muscle. Hum Reprod. 2002 Dec; 17(12):3053-9. PMID: 12456602.
      View in: PubMed
    52. Deng H, Huang A, So SP, Lin YZ, Ruan KH. Substrate access channel topology in membrane-bound prostacyclin synthase. Biochem J. 2002 Mar 15; 362(Pt 3):545-51. PMID: 11879180; PMCID: PMC1222417.
    53. Guo Q, Wang LH, Ruan KH, Kulmacz RJ. Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents. J Biol Chem. 1996 Aug 9; 271(32):19134-9. PMID: 8702589.
      View in: PubMed
    54. Ashizawa T, Ruan KH, Jinnai K, Atassi MZ. Profile of the regions on the alpha-chain of human acetylcholine receptor recognized by autoantibodies in myasthenia gravis. Mol Immunol. 1992 Dec; 29(12):1507-14. PMID: 1280762.
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    55. Atassi MZ, Ruan KH, Jinnai K, Oshima M, Ashizawa T. Epitope-specific suppression of antibody response in experimental autoimmune myasthenia gravis by a monomethoxypolyethylene glycol conjugate of a myasthenogenic synthetic peptide. Proc Natl Acad Sci U S A. 1992 Jul 1; 89(13):5852-6. PMID: 1378618; PMCID: PMC49395.
    56. Ohashi K, Ruan KH, Kulmacz RJ, Wu KK, Wang LH. Primary structure of human thromboxane synthase determined from the cDNA sequence. J Biol Chem. 1992 Jan 15; 267(2):789-93. PMID: 1730669.
      View in: PubMed
    57. Ruan KH, Stiles BG, Atassi MZ. The short-neurotoxin-binding regions on the alpha-chain of human and Torpedo californica acetylcholine receptors. Biochem J. 1991 Mar 15; 274 ( Pt 3):849-54. PMID: 2012611; PMCID: PMC1149988.
    58. Ruan KH, Spurlino J, Quiocho FA, Atassi MZ. Acetylcholine receptor-alpha-bungarotoxin interactions: determination of the region-to-region contacts by peptide-peptide interactions and molecular modeling of the receptor cavity. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6156-60. PMID: 2385590; PMCID: PMC54491.
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