Last Name


TitleAssociate Professor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
AddressTexas Medical Center Campus, Rm 517
1441 Moursund
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Myers AL, Kawedia JD, Champlin RE, Kramer MA, Nieto Y, Ghose R, Andersson BS. Clarifying Busulfan Metabolism and Drug Interactions to Support New Therapeutic Drug Monitoring Strategies: A Comprehensive Review. Expert Opin Drug Metab Toxicol. 2017 Aug 02. PMID: 28766962.
      View in: PubMed
    2. Mallick P, Basu S, Moorthy B, Ghose R. Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro. Toxicol In Vitro. 2017 Feb 27; 41:75-82. PMID: 28242239.
      View in: PubMed
    3. Mallick P, Taneja G, Moorthy B, Ghose R. Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions. Expert Opin Drug Metab Toxicol. 2017 Jun; 13(6):605-616. PMID: 28537216.
      View in: PubMed
    4. Ghose R, Mallick P, Taneja G, Chu C, Moorthy B. In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin. Methods Mol Biol. 2016; 1395:55-68. PMID: 26910068.
      View in: PubMed
    5. Shah P, Omoluabi O, Moorthy B, Ghose R. Role of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon ? in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes. Drug Metab Dispos. 2016 Jan; 44(1):61-7. PMID: 26470915.
      View in: PubMed
    6. Mallick P, Shah P, Gandhi A, Ghose R. Impact of obesity on accumulation of the toxic irinotecan metabolite, SN-38, in mice. Life Sci. 2015 Oct 15; 139:132-8. PMID: 26334566.
      View in: PubMed
    7. Shah P, Guo T, Moore DD, Ghose R. Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters. Drug Metab Dispos. 2014 Jan; 42(1):172-81. PMID: 24194512; PMCID: PMC3876785.
    8. Gandhi A, Moorthy B, Ghose R. Drug disposition in pathophysiological conditions. Curr Drug Metab. 2012 Nov; 13(9):1327-44. PMID: 22746301; PMCID: PMC3937312.
    9. Gandhi A, Shah P, Guo T, Moorthy B, Chow S-L. D, Hu M & Ghose R. Altered pharmacokinetics and pharmacodynamics of the CYP3A substrate, midazolam, during hepatic inflammation induced by bacterial endotoxins. British Journal of Pharmacology. 2012; 166(7):2167-87.
    10. Fahy BN, Guo T, Ghose R. Impact of hepatic malignancy on CYP3A4 gene expression. J Surg Res. 2012 Dec; 178(2):768-72. PMID: 22763214.
      View in: PubMed
    11. Gandhi A and Ghose R. . Altered Drug Metabolism and Transport in Pathophysiological Conditions. 2012.
    12. Ghose R, Omoluabi O, Gandhi A, Shah P, Strohacker K, Carpenter KC, McFarlin B, Guo T. Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters. Life Sci. 2011 Jul 4; 89(1-2):57-64. PMID: 21620874; PMCID: PMC3156825.
    13. Ghose R, Guo T, Vallejo JG, Gandhi A. Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. Drug Metab Dispos. 2011 May; 39(5):874-81. PMID: 21303924; PMCID: PMC3082375.
    14. Gandhi A, Guo T, Ghose R. Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes. J Toxicol Sci. 2010 Apr; 35(2):163-73. PMID: 20371967.
      View in: PubMed
    15. Tam VH, Ledesma KR, Schilling AN, Lim TP, Yuan Z, Ghose R, Lewis RE. In vivo dynamics of carbapenem-resistant Pseudomonas aeruginosa selection after suboptimal dosing. Diagn Microbiol Infect Dis. 2009 Aug; 64(4):427-33. PMID: 19631096.
      View in: PubMed
    16. Ghose R, Guo T, Haque N. Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid. Arch Biochem Biophys. 2009 Jan 1; 481(1):123-30. PMID: 18940178; PMCID: PMC2635100.
    17. Ghose R, White D, Guo T, Vallejo J, Karpen SJ. Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. Drug Metab Dispos. 2008 Jan; 36(1):95-101. PMID: 17932222.
      View in: PubMed
    18. Ghose, R., J. Mulder and S. J. Karpen. Lipoplolysaccharide-mediated down-regulation of hepatic genes is ameliorated by the PPAR? agonist, Rosiglitazone. J Hepatol. 2007; 46(1):115-123.
    19. Zimmerman TL, Thevananther S, Ghose R, Burns AR, Karpen SJ. Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260. J Biol Chem. 2006 Jun 2; 281(22):15434-40. PMID: 16551633.
      View in: PubMed
    20. Ghose R, Zimmerman TL, Thevananther S, Karpen SJ. Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation. Nucl Recept. 2004 Aug 16; 2(1):4. PMID: 15312234.
      View in: PubMed
    21. Ghose R, Malik M, Huber PW. Restricted specificity of Xenopus TFIIIA for transcription of somatic 5S rRNA genes. Mol Cell Biol. 2004 Mar; 24(6):2467-77. PMID: 14993284; PMCID: PMC355861.
    22. Ghose R, Liou LY, Herrmann CH, Rice AP. Induction of TAK (cyclin T1/P-TEFb) in purified resting CD4(+) T lymphocytes by combination of cytokines. J Virol. 2001 Dec; 75(23):11336-43. PMID: 11689614; PMCID: PMC114719.
    23. Foskett SM, Ghose R, Tang DN, Lewis DE, Rice AP. Antiapoptotic function of Cdk9 (TAK/P-TEFb) in U937 promonocytic cells. J Virol. 2001 Feb; 75(3):1220-8. PMID: 11152495; PMCID: PMC114028.
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