Last Name


TitleAssistant Professor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
Address542A Science and Research Building 2
Houston TX 77204-5037
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Walton SD, Chakravarthy H, Shettigar V, O'Neil AJ, Siddiqui JK, Jones BR, Tikunova SB, Davis JP. Divergent Soybean Calmodulins Respond Similarly to Calcium Transients: Insight into Differential Target Regulation. Front Plant Sci. 2017; 8:208. PMID: 28261258.
      View in: PubMed
    2. Siddiqui JK, Tikunova SB, Walton SD, Liu B, Meyer M, de Tombe PP, Neilson N, Kekenes-Huskey PM, Salhi HE, Janssen PM, Biesiadecki BJ, Davis JP. Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I. Front Physiol. 2016; 7:632. PMID: 28066265.
      View in: PubMed
    3. Davis JP, Shettigar V, Tikunova SB, Little SC, Liu B, Siddiqui JK, Janssen PM, Ziolo MT, Walton SD. Designing proteins to combat disease: Cardiac troponin C as an example. Arch Biochem Biophys. 2016 Jul 1; 601:4-10. PMID: 26901433; PMCID: PMC4899299 [Available on 07/01/17].
    4. McConnell BK, Singh S, Fan Q, Hernandez A, Portillo JP, Reiser PJ, Tikunova SB. Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy. Front Physiol. 2015; 6:242. PMID: 26379556.
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    5. Swindle N, Albury AN, Baroud B, Burney M, Tikunova SB. Molecular and functional consequences of mutations in the central helix of cardiac troponin C. Arch Biochem Biophys. 2014 Apr 15; 548:46-53. PMID: 24650606; PMCID: PMC4026335.
    6. Liu B, Tikunova SB, Kline KP, Siddiqui JK, Davis JP. Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. PLoS One. 2012; 7(6):e38259. PMID: 22675533; PMCID: PMC3366952.
    7. Liu B, Lee RS, Biesiadecki BJ, Tikunova SB, Davis JP. Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity. J Biol Chem. 2012 Jun 8; 287(24):20027-36. PMID: 22511780; PMCID: PMC3370186.
    8. Albury AN, Swindle N, Swartz DR, Tikunova SB. Effect of hypertrophic cardiomyopathy-linked troponin C mutations on the response of reconstituted thin filaments to calcium upon troponin I phosphorylation. Biochemistry. 2012 May 1; 51(17):3614-21. PMID: 22489623; PMCID: PMC3341542.
    9. Little SC, Tikunova SB, Norman C, Swartz DR, Davis JP. Measurement of calcium dissociation rates from troponin C in rigor skeletal myofibrils. Front Physiol. 2011; 2:70. PMID: 22013424; PMCID: PMC3190119.
    10. Lee RS, Tikunova SB, Kline KP, Zot HG, Hasbun JE, Minh NV, Swartz DR, Rall JA, Davis JP. Effect of Ca2+ binding properties of troponin C on rate of skeletal muscle force redevelopment. Am J Physiol Cell Physiol. 2010 Nov; 299(5):C1091-9. PMID: 20702687; PMCID: PMC2980305.
    11. Swindle N, Tikunova SB. Hypertrophic cardiomyopathy-linked mutation D145E drastically alters calcium binding by the C-domain of cardiac troponin C. Biochemistry. 2010 Jun 15; 49(23):4813-20. PMID: 20459070; PMCID: PMC2883812.
    12. Tikunova SB, Liu B, Swindle N, Little SC, Gomes AV, Swartz DR, Davis JP. Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems. Biochemistry. 2010 Mar 9; 49(9):1975-84. PMID: 20128626; PMCID: PMC2845643.
    13. Liang B, Chung F, Qu Y, Pavlov D, Gillis TE, Tikunova SB, Davis JP, Tibbits GF. Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility. Physiol Genomics. 2008 Apr 22; 33(2):257-66. PMID: 18285522.
      View in: PubMed
    14. Davis JP, Tikunova SB. Ca(2+) exchange with troponin C and cardiac muscle dynamics. Cardiovasc Res. 2008 Mar 1; 77(4):619-26. PMID: 18079104.
      View in: PubMed
    15. Norman C, Rall JA, Tikunova SB, Davis JP. Modulation of the rate of cardiac muscle contraction by troponin C constructs with various calcium binding affinities. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2580-7. PMID: 17693547.
      View in: PubMed
    16. Kreutziger KL, Gillis TE, Davis JP, Tikunova SB, Regnier M. Influence of enhanced troponin C Ca2+-binding affinity on cooperative thin filament activation in rabbit skeletal muscle. J Physiol. 2007 Aug 15; 583(Pt 1):337-50. PMID: 17584846; PMCID: PMC2277218.
    17. Davis JP, Norman C, Kobayashi T, Solaro RJ, Swartz DR, Tikunova SB. Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Biophys J. 2007 May 1; 92(9):3195-206. PMID: 17293397; PMCID: PMC1852344.
    18. Engel PL, Kobayashi T, Biesiadecki B, Davis J, Tikunova S, Wu S, Solaro RJ. Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments. J Biol Chem. 2007 Jan 5; 282(1):183-93. PMID: 17099250.
      View in: PubMed
    19. Swartz DR, Yang Z, Sen A, Tikunova SB, Davis JP. Myofibrillar troponin exists in three states and there is signal transduction along skeletal myofibrillar thin filaments. J Mol Biol. 2006 Aug 18; 361(3):420-35. PMID: 16857209; PMCID: PMC2834179.
    20. Fidalgo da Silva E, Freire MM, Barrabin H, Sorenson MM, Tikunova S, Johnson JD, Chandra M, Pearlstone JR, Scofano HM. Troponin C/calmodulin chimeras as erythrocyte plasma membrane Ca2+-ATPase activators. Int J Biochem Cell Biol. 2006 Feb; 38(2):209-21. PMID: 16213185.
      View in: PubMed
    21. Gomes AV, Venkatraman G, Davis JP, Tikunova SB, Engel P, Solaro RJ, Potter JD. Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart. J Biol Chem. 2004 Nov 26; 279(48):49579-87. PMID: 15358779.
      View in: PubMed
    22. Tikunova SB, Davis JP. Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C. J Biol Chem. 2004 Aug 20; 279(34):35341-52. PMID: 15205455.
      View in: PubMed
    23. Davis JP, Rall JA, Alionte C, Tikunova SB. Mutations of hydrophobic residues in the N-terminal domain of troponin C affect calcium binding and exchange with the troponin C-troponin I96-148 complex and muscle force production. J Biol Chem. 2004 Apr 23; 279(17):17348-60. PMID: 14970231.
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    24. Davis JP, Rall JA, Reiser PJ, Smillie LB, Tikunova SB. Engineering competitive magnesium binding into the first EF-hand of skeletal troponin C. J Biol Chem. 2002 Dec 20; 277(51):49716-26. PMID: 12397067.
      View in: PubMed
    25. Tikunova SB, Rall JA, Davis JP. Effect of hydrophobic residue substitutions with glutamine on Ca(2+) binding and exchange with the N-domain of troponin C. Biochemistry. 2002 May 28; 41(21):6697-705. PMID: 12022873.
      View in: PubMed
    26. Van Lierop JE, Wilson DP, Davis JP, Tikunova S, Sutherland C, Walsh MP, Johnson JD. Activation of smooth muscle myosin light chain kinase by calmodulin. Role of LYS(30) and GLY(40). J Biol Chem. 2002 Feb 22; 277(8):6550-8. PMID: 11748245.
      View in: PubMed
    27. Tang J, Lin Y, Zhang Z, Tikunova S, Birnbaumer L, Zhu MX. Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. J Biol Chem. 2001 Jun 15; 276(24):21303-10. PMID: 11290752; PMCID: PMC1847329.
    28. Tikunova SB, Black DJ, Johnson JD, Davis JP. Modifying Mg2+ binding and exchange with the N-terminal of calmodulin. Biochemistry. 2001 Mar 20; 40(11):3348-53. PMID: 11258955.
      View in: PubMed
    29. Zhang Z, Tang J, Tikunova S, Johnson JD, Chen Z, Qin N, Dietrich A, Stefani E, Birnbaumer L, Zhu MX. Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3168-73. PMID: 11248050; PMCID: PMC30625.
    30. Adak S, Santolini J, Tikunova S, Wang Q, Johnson JD, Stuehr DJ. Neuronal nitric-oxide synthase mutant (Ser-1412 --> Asp) demonstrates surprising connections between heme reduction, NO complex formation, and catalysis. J Biol Chem. 2001 Jan 12; 276(2):1244-52. PMID: 11038355.
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    31. Black DJ, Tikunova SB, Johnson JD, Davis JP. Acid pairs increase the N-terminal Ca2+ affinity of CaM by increasing the rate of Ca2+ association. Biochemistry. 2000 Nov 14; 39(45):13831-7. PMID: 11076523.
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    32. Kondo R, Tikunova SB, Cho MJ, Johnson JD. A point mutation in a plant calmodulin is responsible for its inhibition of nitric-oxide synthase. J Biol Chem. 1999 Dec 17; 274(51):36213-8. PMID: 10593908.
      View in: PubMed
    33. Davis JP, Tikunova SB, Walsh MP, Johnson JD. Characterizing the response of calcium signal transducers to generated calcium transients. Biochemistry. 1999 Mar 30; 38(13):4235-44. PMID: 10194340.
      View in: PubMed
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