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Last Name
Institution

CHANGYI JOHNNY CHEN

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
AddressOne Baylor Plaza, R413
Houston TX 77021
Other Positions
TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology


 Overview 
 overview
Cardiovascular risk factors and their molecular mechanisms in cardiovascular disease

We are investigating the effects and the molecular mechanisms of several cardiovascular risk factors, including HIV protease inhibitors, the adipokine resistin, soluble CD40L, and uric acid, on biochemical pathways associated with endothelial cell functions. Some of the biochemical pathways under investigation are the endothelial nitric oxide synthase system, the oxidative stress system, and signal transduction pathways. We are carrying on these investigations using several experimental models, such as myographies, organ cultures, mouse models, human tissue samples, and different types of endothelial cells. Based on the molecular mechanisms we uncover, we develop effective therapeutic strategies to treat endothelial dysfunction and atherosclerosis.

Endothelial cell differentiation and angiogenesis

We are studying the role played by and the molecular mechanisms of hemodynamic factors and several novel molecules on endothelial cells differentiated from embryonic stem cells and from bone marrow-derived stem cells. We are identifying key regulatory genes that trigger endothelial cell differentiation and promote stable angiogenesis. These findings can potentially be applied to the design of novel therapeutic strategies to treat ischemic tissues using genetically engineered endothelial cells. In addition, these studies may provide useful information to genetically engineer novel tissues for vascular grafts.

Pancreatic cancer

We have been heavily involved in pancreatic cancer research programs for many years. We have several projects focusing on the role and on the mechanisms of several genes, such as microRNA 196a (miR-196a), X-inactive specific transcript (XIST), and Jude-2 in pancreatic cancer. Our comprehensive studies analyze human cancer specimens, clinical outcomes, established cell lines, a nude mouse model, and a genetically engineered mouse model of pancreatic cancer called the KPC model. We are developing PLGA [poly(lactic-co-glycolic acid)]-based nanotechnology for molecular imaging and for specific drug and gene delivery, which has great potential clinical applications, such as molecular diagnostics and targeted therapies.

 keywords
Angiogenesis, Atherosclerosis, Cardiovascular disease, Endothelial dysfunction, Endothelial nitric oxide synthase, Hemodynamics, Oxidative stress, Pancreatic cancer, PLGA-based nanotechnology, Vascular tissue engineering


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mu H, Ohashi R, Yan S, Chai H, Yang H, Lin P, Yao Q, Chen C. Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res. 2006 Apr 1; 70(1):146-57.
    View in: PubMed
  2. Mohiuddin I, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular system. J Surg Res. 2006 Jun 15; 133(2):143-9.
    View in: PubMed
  3. Ohashi R, Yan S, Mu H, Chai H, Yao Q, Lin PH, Chen C. Effects of homocysteine and ginsenoside Rb1 on endothelial proliferation and superoxide anion production. J Surg Res. 2006 Jun 15; 133(2):89-94.
    View in: PubMed
  4. Li M, Wang H, Li F, Fisher WE, Chen C, Yao Q. Effect of cyclophilin A on gene expression in human pancreatic cancer cells. Am J Surg. 2005 Nov; 190(5):739-45.
    View in: PubMed
  5. Chai H, Yang H, Yan S, Li M, Lin PH, Lumsden AB, Yao Q, Chen C. Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries. J Acquir Immune Defic Syndr. 2005 Sep 1; 40(1):12-9.
    View in: PubMed
  6. Yan S, Chai H, Wang H, Yang H, Nan B, Yao Q, Chen C. Effects of lysophosphatidylcholine on monolayer cell permeability of human coronary artery endothelial cells. Surgery. 2005 Sep; 138(3):464-73.
    View in: PubMed
  7. Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C. Review: application of stem cells for vascular tissue engineering. Tissue Eng. 2005 Sep-Oct; 11(9-10):1535-52.
    View in: PubMed
  8. Nan B, Yang H, Yan S, Lin PH, Lumsden AB, Yao Q, Chen C. C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery. 2005 Aug; 138(2):212-22.
    View in: PubMed
  9. Safaya R, Chai H, Kougias P, Lin P, Lumsden A, Yao Q, Chen C. Effect of lysophosphatidylcholine on vasomotor functions of porcine coronary arteries. J Surg Res. 2005 Jun 15; 126(2):182-8.
    View in: PubMed
  10. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. Effects of adipocyte-derived cytokines on endothelial functions: implication of vascular disease. J Surg Res. 2005 Jun 1; 126(1):121-9.
    View in: PubMed
  11. Fu W, Chai H, Yao Q, Chen C. Effects of HIV protease inhibitor ritonavir on vasomotor function and endothelial nitric oxide synthase expression. J Acquir Immune Defic Syndr. 2005 Jun 1; 39(2):152-8.
    View in: PubMed
  12. Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C. Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries. J Am Coll Surg. 2005 Jun; 200(6):820-30.
    View in: PubMed
  13. Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C. Roles of hemodynamic forces in vascular cell differentiation. Ann Biomed Eng. 2005 Jun; 33(6):772-9.
    View in: PubMed
  14. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2005 May; 41(5):861-8.
    View in: PubMed
  15. Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C. Roles of cyclophilins in cancers and other organ systems. World J Surg. 2005 Mar; 29(3):276-80.
    View in: PubMed
  16. Chen C, Li M, Chai H, Yang H, Fisher WE, Yao Q. Roles of neuropilins in neuronal development, angiogenesis, and cancers. World J Surg. 2005 Mar; 29(3):271-5.
    View in: PubMed
  17. Chen C, Li M, Yang H, Chai H, Fisher W, Yao Q. Roles of thymosins in cancers and other organ systems. World J Surg. 2005 Mar; 29(3):264-70.
    View in: PubMed
  18. Lin PH, Bush RL, Nguyen L, Guerrero MA, Chen C, Lumsden AB. Anastomotic strategies to improve hemodialysis access patency--a review. Vasc Endovascular Surg. 2005 Mar-Apr; 39(2):135-42.
    View in: PubMed
  19. Rodriguez JA, Li M, Yao Q, Chen C, Fisher WE. Gene overexpression in pancreatic adenocarcinoma: diagnostic and therapeutic implications. World J Surg. 2005 Mar; 29(3):297-305.
    View in: PubMed
  20. Li M, Fisher WE, Kim HJ, Wang X, Brunicardi CF, Chen C, Yao Q. Somatostatin, somatostatin receptors, and pancreatic cancer. World J Surg. 2005 Mar; 29(3):293-6.
    View in: PubMed
  21. Wang XP, Yazawa K, Templeton NS, Yang J, Liu S, Li Z, Li M, Yao Q, Chen C, Brunicardi FC. Intravenous delivery of liposome-mediated nonviral DNA is less toxic than intraperitoneal delivery in mice. World J Surg. 2005 Mar; 29(3):339-43.
    View in: PubMed
  22. Doan LX, Li M, Chen C, Yao Q. Virus-like particles as HIV-1 vaccines. Rev Med Virol. 2005 Mar-Apr; 15(2):75-88.
    View in: PubMed
  23. Cox MW, Fu W, Chai H, Paladugu R, Lin PH, Lumsden AB, Yao Q, Chen C. Effects of progesterone and estrogen on endothelial dysfunction in porcine coronary arteries. J Surg Res. 2005 Mar; 124(1):104-11.
    View in: PubMed
  24. Yan S, Li M, Chai H, Yang H, Lin PH, Yao Q, Chen C. TNF-alpha decreases expression of somatostatin, somatostatin receptors, and cortistatin in human coronary endothelial cells. J Surg Res. 2005 Feb; 123(2):294-301.
    View in: PubMed
  25. Yang H, Li M, Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C. Effects of cyclophilin A on cell proliferation and gene expressions in human vascular smooth muscle cells and endothelial cells. J Surg Res. 2005 Feb; 123(2):312-9.
    View in: PubMed
  26. Mu H, Ohashi R, Lin P, Yao Q, Chen C. Cellular and molecular mechanisms of coronary vessel development. Vasc Med. 2005 Feb; 10(1):37-44.
    View in: PubMed
  27. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. Defensins and cathelicidins: neutrophil peptides with roles in inflammation, hyperlipidemia and atherosclerosis. J Cell Mol Med. 2005 Jan-Mar; 9(1):3-10.
    View in: PubMed
  28. Lin PH, Bush RL, Yao Q, Lam R, Paladugu R, Zhou W, Chen C, Lumsden AB. Abdominal aortic surgery in patients with human immunodeficiency virus infection. Am J Surg. 2004 Dec; 188(6):690-7.
    View in: PubMed
  29. Yang H, Li M, Chai H, Yan S, Zhang R, Yao Q, Chen C. Expression and regulation of neuropilins and VEGF receptors by TNF-alpha in human endothelial cells. J Surg Res. 2004 Dec; 122(2):249-55.
    View in: PubMed
  30. Ramaswami G, Chai H, Yao Q, Lin PH, Lumsden AB, Chen C. Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2004 Dec; 40(6):1216-22.
    View in: PubMed
  31. Zhang R, Li M, Chen C, Yao Q. SHIV virus-like particles bind and activate human dendritic cells. Vaccine. 2004 Nov 25; 23(2):139-47.
    View in: PubMed
  32. Li M, Yang H, Chai H, Fisher WE, Wang X, Brunicardi FC, Yao Q, Chen C. Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors. Cancer. 2004 Nov 15; 101(10):2341-50.
    View in: PubMed
  33. Nan B, Lin P, Lumsden AB, Yao Q, Chen C. Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Thromb Res. 2005; 115(5):417-26.
    View in: PubMed
  34. Ohashi R, Mu H, Yao Q, Chen C. Cellular and molecular mechanisms of atherosclerosis with mouse models. Trends Cardiovasc Med. 2004 Jul; 14(5):187-90.
    View in: PubMed
  35. Conklin BS, Fu W, Lin PH, Lumsden AB, Yao Q, Chen C. HIV protease inhibitor ritonavir decreases endothelium-dependent vasorelaxation and increases superoxide in porcine arteries. Cardiovasc Res. 2004 Jul 1; 63(1):168-75.
    View in: PubMed
  36. Li M, Li W, Kim HJ, Yao Q, Chen C, Fisher WE. Characterization of somatostatin receptor expression in human pancreatic cancer using real-time RT-PCR. J Surg Res. 2004 Jun 15; 119(2):130-7.
    View in: PubMed
  37. Wu H, Yao Q, Lumsden A, Chen C. Characterization of two populations of human coronary artery endothelial cells(1). J Surg Res. 2004 May 1; 118(1):38-44.
    View in: PubMed
  38. Spencer TA, Chai H, Fu W, Ramaswami G, Cox MW, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Estrogen blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries(1,2). J Surg Res. 2004 May 1; 118(1):83-90.
    View in: PubMed
  39. Lin PH, Bush RL, Chen C, Lumsden AB. What is new in the preoperative evaluation of arteriovenous access operation? Semin Vasc Surg. 2004 Mar; 17(1):57-63.
    View in: PubMed
  40. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Clinical use and molecular mechanisms of action of extract of Ginkgo biloba leaves in cardiovascular diseases. Cardiovasc Drug Rev. 2004; 22(4):309-19.
    View in: PubMed
  41. Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Red wine prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Surg Res. 2003 Nov; 115(1):82-91.
    View in: PubMed
  42. Paladugu R, Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Hiv Tat protein causes endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2003 Sep; 38(3):549-55; discussion 555-6.
    View in: PubMed
  43. Lin PH, Bush RL, Milas M, Terramani TT, Dodson TF, Chen C, Chaikof EL, Lumsden AB. Impact of an endovascular program on the operative experience of abdominal aortic aneurysm in vascular fellowship and general surgery residency. Am J Surg. 2003 Aug; 186(2):189-93.
    View in: PubMed
  44. Bush RL, Lin PH, Reddy PP, Chen C, Weiss VJ, Guinn G, Lumsden AB. Epidural analgesia in patients with chronic obstructive pulmonary disease undergoing transperitoneal abdominal aortic aneurysmorraphy--a multi-institutional analysis. Cardiovasc Surg. 2003 Jun; 11(3):179-84.
    View in: PubMed
  45. Lin PH, Chronos NA, Marijianowski MM, Chen C, Bush RL, Conklin B, Lumsden AB, Hanson SR. Heparin-coated balloon-expandable stent reduces intimal hyperplasia in the iliac artery in baboons. J Vasc Interv Radiol. 2003 May; 14(5):603-11.
    View in: PubMed
  46. Lin PH, Martin L, Matsuura JH, Wellons E, Bush RL, Terramani TT, Chen C, Lumsden AB. Intraaortic stabilization of the AneuRx stent-graft system: a useful adjunct to minimize device migration. Cardiovasc Intervent Radiol. 2003 Jan-Feb; 26(1):73-5.
    View in: PubMed
  47. Lin PH, Kulbaski MJ, Terramani TT, Bush RL, Brinkman WT, Chen C, Conklin B, Lumsden AB. The regained referral ground and clinical practice of vena cava filter placement in vascular surgery. Am Surg. 2002 Oct; 68(10):865-70.
    View in: PubMed
  48. Lin PH, Bush RL, Chaikof EL, Chen C, Conklin B, Terramani TT, Brinkman WT, Lumsden AB. A prospective evaluation of hypogastric artery embolization in endovascular aortoiliac aneurysm repair. J Vasc Surg. 2002 Sep; 36(3):500-6.
    View in: PubMed
  49. Lin PH, Bush RL, Conklin BS, Chen C, Weiss VJ, Chaikof EL, Lumsden AB. Late complication of aortoiliac stent placement- atheroembolization of the lower extremities. J Surg Res. 2002 Apr; 103(2):153-9.
    View in: PubMed
  50. Ren Z, Yao Q, Chen C. HIV-1 envelope glycoprotein 120 increases intercellular adhesion molecule-1 expression by human endothelial cells. Lab Invest. 2002 Mar; 82(3):245-55.
    View in: PubMed
  51. Chen C, Conklin BS, Ren Z, Zhong DS. Homocysteine decreases endothelium-dependent vasorelaxation in porcine arteries. J Surg Res. 2002 Jan; 102(1):22-30.
    View in: PubMed
  52. Conklin BS, Zhong DS, Zhao W, Lin PH, Chen C. Shear stress regulates occludin and VEGF expression in porcine arterial endothelial cells. J Surg Res. 2002 Jan; 102(1):13-21.
    View in: PubMed
  53. Chen C, Surowiec SM, Morsy AH, Ma M. Intraperitoneal infusion of homocysteine increases intimal hyperplasia in balloon-injured rat carotid arteries. Atherosclerosis. 2002 Jan; 160(1):103-14.
    View in: PubMed
  54. Lin PH, Dodson TF, Bush RL, Weiss VJ, Conklin BS, Chen C, Chaikof EL, Lumsden AB. Surgical intervention for complications caused by femoral artery catheterization in pediatric patients. J Vasc Surg. 2001 Dec; 34(6):1071-8.
    View in: PubMed
  55. Yao Q, Compans RW, Chen C. HIV envelope proteins differentially utilize CXCR4 and CCR5 coreceptors for induction of apoptosis. Virology. 2001 Jun 20; 285(1):128-37.
    View in: PubMed
  56. Lin PH, Chen C, Surowiec SM, Conklin B, Bush RL, Lumsden AB. Evaluation of thrombolysis in a porcine model of chronic deep venous thrombosis: an endovascular model. J Vasc Surg. 2001 Mar; 33(3):621-7.
    View in: PubMed
  57. Lin PH, Surowiec SM, Conklin B, Bush RL, Chen C, Chaikof EL, Lumsden AB. An endovascular model of carotid stenosis for the evaluation of thrombolysis and angioplasty. J Endovasc Ther. 2000 Dec; 7(6):486-93.
    View in: PubMed
  58. Lin PH, Surowiec SM, Conklin B, Chen C, Bush R, Weiss VJ, Lumsden AB. Evaluation of thrombolysis and angioplasty in a porcine iliac artery thrombosis model: application of endovascular stent-graft-induced thrombosis. J Vasc Interv Radiol. 2000 Jun; 11(6):785-91.
    View in: PubMed
  59. Yao Q, Kuhlmann FM, Eller R, Compans RW, Chen C. Production and characterization of simian--human immunodeficiency virus-like particles. AIDS Res Hum Retroviruses. 2000 Feb 10; 16(3):227-36.
    View in: PubMed
  60. Chen C, Halkos ME, Surowiec SM, Conklin BS, Lin PH, Lumsden AB. Effects of homocysteine on smooth muscle cell proliferation in both cell culture and artery perfusion culture models. J Surg Res. 2000 Jan; 88(1):26-33.
    View in: PubMed
  61. Chen C, Mattar SG, Lumsden AB. Oral administration of L-arginine reduces intimal hyperplasia in balloon-injured rat carotid arteries. J Surg Res. 1999 Mar; 82(1):17-23.
    View in: PubMed
  62. Chen C, Ofenloch JC, Yianni YP, Hanson SR, Lumsden AB. Phosphorylcholine coating of ePTFE reduces platelet deposition and neointimal hyperplasia in arteriovenous grafts. J Surg Res. 1998 Jul 1; 77(2):119-25.
    View in: PubMed
  63. Chen C, Li J, Micko CJ, Pierce GF, Cunningham MR, Lumsden AB. Cytotoxic effects of basic FGF and heparin binding EGF conjugated with cytotoxin saporin on vascular cell cultures. J Surg Res. 1998 Feb 15; 75(1):35-41.
    View in: PubMed
  64. Morsy AH, Kulbaski M, Chen C, Isiklar H, Lumsden AB. Incidence and characteristics of patients with hand ischemia after a hemodialysis access procedure. J Surg Res. 1998 Jan; 74(1):8-10.
    View in: PubMed
  65. Chen C, Li J, Mattar SG, Pierce GF, Aukerman L, Hanson SR, Lumsden AB. Boundary layer infusion of basic fibroblast growth factor accelerates intimal hyperplasia in endarterectomized canine artery. J Surg Res. 1997 May; 69(2):300-6.
    View in: PubMed
  66. Ofenloch JC, Chen C, Hughes JD, Lumsden AB. Endoscopic venous valve transplantation with a valve-stent device. Ann Vasc Surg. 1997 Jan; 11(1):62-7.
    View in: PubMed
  67. Chen C, Hanson SR, Keefer LK, Saavedra JE, Davies KM, Hutsell TC, Hughes JD, Ku DN, Lumsden AB. Boundary layer infusion of nitric oxide reduces early smooth muscle cell proliferation in the endarterectomized canine artery. J Surg Res. 1997 Jan; 67(1):26-32.
    View in: PubMed
  68. Chen C, Hughes JD, Mattar SG, Ku DN, Lumsden AB. Time-course study of intimal hyperplasia in the endarterectomized canine artery. J Surg Res. 1997 Jan; 67(1):106-12.
    View in: PubMed
  69. Lumsden AB, Chen C, Coyle KA, Ofenloch JC, Wang JH, Yasuda HK, Hanson SR. Nonporous silicone polymer coating of expanded polytetrafluoroethylene grafts reduces graft neointimal hyperplasia in dog and baboon models. J Vasc Surg. 1996 Nov; 24(5):825-33.
    View in: PubMed
  70. Hughes JD, Chen C, Mattar SG, Someren A, Noe B, Suwyn CR, Lumsden AB. Normothermic renal artery perfusion: a comparison of perfusates. Ann Vasc Surg. 1996 Mar; 10(2):123-30.
    View in: PubMed
  71. Hughes JD, Mattar SG, Chen C, Someren A, Noe B, Suwyn CR, Lumsden AB. Renal artery perfusion modifies ischemia/reperfusion injury. J Surg Res. 1996 Feb 1; 60(2):321-6.
    View in: PubMed
  72. Chen C, Ku DN, Kikeri D, Lumsden AB. Tenascin: a potential role in human arteriovenous PTFE graft failure. J Surg Res. 1996 Feb 1; 60(2):409-16.
    View in: PubMed
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