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ANTHONY RICHARD FLORES

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Infectious Diseases
Address1102 BATES, SUITE 1120
HOUSTON TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Flores AR, Luna RA, Runge JK, Shelburne SA, Baker CJ. Cluster of fatal group A streptococcal emm87 infection within a single family: molecular basis for invasion and transmission. J Infect Dis. 2017 Apr 05. PMID: 28383686.
      View in: PubMed
    2. Flores AR, Olsen RJ, Cantu C, Pallister KB, Guerra FE, Voyich JM, Musser JM. Increased pilus production conferred by a naturally occurring mutation alters host-pathogen interaction in favor of carriage in Streptococcus pyogenes. Infect Immun. 2017 Mar 06. PMID: 28264907.
      View in: PubMed
    3. Branson J, Vallejo JG, Flores AR, Hulten KG, Mason EO, Kaplan SL, McNeil JC. The Contemporary Microbiology and Rates of Concomitant Osteomyelitis in Acute Septic Arthritis. Pediatr Infect Dis J. 2016 Nov 18. PMID: 27870814.
      View in: PubMed
    4. McNeil JC, Forbes AR, Vallejo JG, Flores AR, Hultén KG, Mason EO, Kaplan SL. Role of Operative or Interventional Radiology-Guided Cultures for Osteomyelitis. Pediatrics. 2016 May; 137(5). PMID: 27244827.
      View in: PubMed
    5. Galloway-Peña J, Clement ME, Sharma Kuinkel BK, Ruffin F, Flores AR, Levinson H, Shelburne SA, Moore Z, Fowler VG. Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease. Open Forum Infect Dis. 2016 Jan; 3(1):ofw042. PMID: 27006966; PMCID: PMC4800461.
    6. Olsen RJ, Raghuram A, Cantu C, Hartman MH, Jimenez FE, Lee S, Ngo A, Rice KA, Saddington D, Spillman H, Valson C, Flores AR, Beres SB, Long SW, Nasser W, Musser JM. The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: pathogenesis implications. Infect Immun. 2015 Dec; 83(12):4750-8. PMID: 26416912; PMCID: PMC4645388 [Available on 06/01/16].
    7. Flores AR, Jewell BE, Yelamanchili D, Olsen RJ, Musser JM. A Single Amino Acid Replacement in the Sensor Kinase LiaS Contributes to a Carrier Phenotype in Group A Streptococcus. Infect Immun. 2015 Nov; 83(11):4237-46. PMID: 26283331.
      View in: PubMed
    8. Teatero S, Athey TB, Van Caeseele P, Horsman G, Alexander DC, Melano RG, Li A, Flores AR, Shelburne SA, McGeer A, Demczuk W, Martin I, Fittipaldi N. Emergence of Serotype IV Group B Streptococcus Adult Invasive Disease in Manitoba and Saskatchewan, Canada, Is Driven by Clonal Sequence Type 459 Strains. J Clin Microbiol. 2015 Sep; 53(9):2919-26. PMID: 26135871; PMCID: PMC4540936.
    9. Flores AR, Galloway-Peña J, Sahasrabhojane P, Saldaña M, Yao H, Su X, Ajami NJ, Holder ME, Petrosino JF, Thompson E, Margarit Y Ros I, Rosini R, Grandi G, Horstmann N, Teatero S, McGeer A, Fittipaldi N, Rappuoli R, Baker CJ, Shelburne SA. Sequence type 1 group B Streptococcus, an emerging cause of invasive disease in adults, evolves by small genetic changes. Proc Natl Acad Sci U S A. 2015 May 19; 112(20):6431-6. PMID: 25941374.
      View in: PubMed
    10. Flores AR, Jewell BE, Versalovic EM, Olsen RJ, Bachert BA, Lukomski S, Musser JM. Natural variant of collagen-like protein a in serotype M3 group a Streptococcus increases adherence and decreases invasive potential. Infect Immun. 2015 Mar; 83(3):1122-9. PMID: 25561712; PMCID: PMC4333440.
    11. Horstmann N, Sahasrabhojane P, Saldaña M, Ajami NJ, Flores AR, Sumby P, Liu CG, Yao H, Su X, Thompson E, Shelburne SA. Characterization of the effect of the histidine kinase CovS on response regulator phosphorylation in group A Streptococcus. Infect Immun. 2015 Mar; 83(3):1068-77. PMID: 25561708; PMCID: PMC4333468.
    12. Sanson M, Makthal N, Flores AR, Olsen RJ, Musser JM, Kumaraswami M. Adhesin competence repressor (AdcR) from Streptococcus pyogenes controls adaptive responses to zinc limitation and contributes to virulence. Nucleic Acids Res. 2015 Jan; 43(1):418-32. PMID: 25510500; PMCID: PMC4288194.
    13. Sanson M, O'Neill BE, Kachroo P, Anderson JR, Flores AR, Valson C, Cantu CC, Makthal N, Karmonik C, Fittipaldi N, Kumaraswami M, Musser JM, Olsen RJ. A naturally occurring single amino acid replacement in multiple gene regulator of group A Streptococcus significantly increases virulence. Am J Pathol. 2015 Feb; 185(2):462-71. PMID: 25476528; PMCID: PMC4305177.
    14. Flores AR, Jewell BE, Olsen RJ, Shelburne SA, Fittipaldi N, Beres SB, Musser JM. Asymptomatic carriage of group A streptococcus is associated with elimination of capsule production. Infect Immun. 2014 Sep; 82(9):3958-67. PMID: 25024363; PMCID: PMC4187823.
    15. Shelburne SA, Sahasrabhojane P, Saldana M, Yao H, Su X, Horstmann N, Thompson E, Flores AR. Streptococcus mitis strains causing severe clinical disease in cancer patients. Emerg Infect Dis. 2014 May; 20(5):762-71. PMID: 24750901; PMCID: PMC4012796.
    16. Flores AR, Sahasrabhojane P, Saldaña M, Galloway-Peña J, Olsen RJ, Musser JM, Shelburne SA. Molecular characterization of an invasive phenotype of group A Streptococcus arising during human infection using whole genome sequencing of multiple isolates from the same patient. J Infect Dis. 2014 May 15; 209(10):1520-3. PMID: 24307742; PMCID: PMC3997578.
    17. Flores AR, Olsen RJ, Wunsche A, Kumaraswami M, Shelburne SA, Carroll RK, Musser JM. Natural variation in the promoter of the gene encoding the Mga regulator alters host-pathogen interactions in group a Streptococcus carrier strains. Infect Immun. 2013 Nov; 81(11):4128-38. PMID: 23980109; PMCID: PMC3811816.
    18. Verhaegh SJ, Flores AR, van Belkum A, Musser JM, Hays JP. Differential virulence gene expression of group A Streptococcus serotype M3 in response to co-culture with Moraxella catarrhalis. PLoS One. 2013; 8(4):e62549. PMID: 23626831; PMCID: PMC3633897.
    19. Flores AR, Jewell BE, Fittipaldi N, Beres SB, Musser JM. Human disease isolates of serotype m4 and m22 group a streptococcus lack genes required for hyaluronic acid capsule biosynthesis. MBio. 2012; 3(6):e00413-12. PMID: 23131832; PMCID: PMC3487777.
    20. Fittipaldi N, Beres SB, Olsen RJ, Kapur V, Shea PR, Watkins ME, Cantu CC, Laucirica DR, Jenkins L, Flores AR, Lovgren M, Ardanuy C, Liñares J, Low DE, Tyrrell GJ, Musser JM. Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group A Streptococcus. Am J Pathol. 2012 Apr; 180(4):1522-34. PMID: 22330677.
      View in: PubMed
    21. Olsen RJ, Laucirica DR, Watkins ME, Feske ML, Garcia-Bustillos JR, Vu C, Cantu C, Shelburne SA, Fittipaldi N, Kumaraswami M, Shea PR, Flores AR, Beres SB, Lovgren M, Tyrrell GJ, Efstratiou A, Low DE, Van Beneden CA, Musser JM. Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus. J Infect Dis. 2012 Jun; 205(11):1719-29. PMID: 22262791; PMCID: PMC4447876.
    22. Shea PR, Ewbank AL, Gonzalez-Lugo JH, Martagon-Rosado AJ, Martinez-Gutierrez JC, Rehman HA, Serrano-Gonzalez M, Fittipaldi N, Beres SB, Flores AR, Low DE, Willey BM, Musser JM. Group A Streptococcus emm gene types in pharyngeal isolates, Ontario, Canada, 2002-2010. Emerg Infect Dis. 2011 Nov; 17(11):2010-7. PMID: 22099088; PMCID: PMC3310556.
    23. Horstmann N, Sahasrabhojane P, Suber B, Kumaraswami M, Olsen RJ, Flores A, Musser JM, Brennan RG, Shelburne SA. Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. PLoS Pathog. 2011 Oct; 7(10):e1002311. PMID: 22028655; PMCID: PMC3197619.
    24. Wright AM, Beres SB, Consamus EN, Long SW, Flores AR, Barrios R, Richter GS, Oh SY, Garufi G, Maier H, Drews AL, Stockbauer KE, Cernoch P, Schneewind O, Olsen RJ, Musser JM. Rapidly progressive, fatal, inhalation anthrax-like infection in a human: case report, pathogen genome sequencing, pathology, and coordinated response. Arch Pathol Lab Med. 2011 Nov; 135(11):1447-59. PMID: 21882964.
      View in: PubMed
    25. Carroll RK, Beres SB, Sitkiewicz I, Peterson L, Matsunami RK, Engler DA, Flores AR, Sumby P, Musser JM. Evolution of diversity in epidemics revealed by analysis of the human bacterial pathogen group A Streptococcus. Epidemics. 2011 Sep; 3(3-4):159-70. PMID: 22094339.
      View in: PubMed
    26. Carroll RK, Shelburne SA, Olsen RJ, Suber B, Sahasrabhojane P, Kumaraswami M, Beres SB, Shea PR, Flores AR, Musser JM. Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice. J Clin Invest. 2011 May; 121(5):1956-68. PMID: 21490401; PMCID: PMC3083769.
    27. Shea PR, Beres SB, Flores AR, Ewbank AL, Gonzalez-Lugo JH, Martagon-Rosado AJ, Martinez-Gutierrez JC, Rehman HA, Serrano-Gonzalez M, Fittipaldi N, Ayers SD, Webb P, Willey BM, Low DE, Musser JM. Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5039-44. PMID: 21383167; PMCID: PMC3064369.
    28. Flores AR, Szilagyi PG, Auinger P, Fisher SG. Estimated burden of rotavirus-associated diarrhea in ambulatory settings in the United States. Pediatrics. 2010 Feb; 125(2):e191-8. PMID: 20100749.
      View in: PubMed
    29. McDonough JA, Hacker KE, Flores AR, Pavelka MS, Braunstein M. The twin-arginine translocation pathway of Mycobacterium smegmatis is functional and required for the export of mycobacterial beta-lactamases. J Bacteriol. 2005 Nov; 187(22):7667-79. PMID: 16267291; PMCID: PMC1280313.
    30. Flores AR, Parsons LM, Pavelka MS. Characterization of novel Mycobacterium tuberculosis and Mycobacterium smegmatis mutants hypersusceptible to beta-lactam antibiotics. J Bacteriol. 2005 Mar; 187(6):1892-900. PMID: 15743935; PMCID: PMC1064048.
    31. Flores AR, Parsons LM, Pavelka MS. Genetic analysis of the beta-lactamases of Mycobacterium tuberculosis and Mycobacterium smegmatis and susceptibility to beta-lactam antibiotics. Microbiology. 2005 Feb; 151(Pt 2):521-32. PMID: 15699201.
      View in: PubMed
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