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MOTONARI UESUGI

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
DivisionBiochemistry & Molecular Biology
AddressOne Baylor Plaza, N411
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chen IS, Tateyama M, Fukata Y, Uesugi M, Kubo Y. Ivermectin activates GIRK channels in a PIP2 -dependent, G?? -independent manner and an amino acid residue at the slide helix governs the activation. J Physiol. 2017 Jul 17. PMID: 28715108.
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    2. Kawagoe F, Sugiyama T, Uesugi M, Kittaka A. Recent Developments for Introducing a Hexafluoroisopropanol Unit into the Vitamin D Side Chain. J Steroid Biochem Mol Biol. 2017 Jul 14. PMID: 28716761.
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    3. Kamei KI, Mashimo Y, Yoshioka M, Tokunaga Y, Fockenberg C, Terada S, Koyama Y, Nakajima M, Shibata-Seki T, Liu L, Akaike T, Kobatake E, How SE, Uesugi M, Chen Y. Microfluidic-Nanofiber Hybrid Array for Screening of Cellular Microenvironments. Small. 2017 Mar 08. PMID: 28272774.
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    4. Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M. Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP. Cell Chem Biol. 2017 Jan 23. PMID: 28132894.
      View in: PubMed
    5. Mao D, Ando S, Sato SI, Qin Y, Hirata N, Katsuda Y, Kawase E, Kuo TF, Minami I, Shiba Y, Ueda K, Nakatsuji N, Uesugi M. A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures. Angew Chem Int Ed Engl. 2017 Jan 09. PMID: 28067441.
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    6. Katsuda Y, Sato S, Asano L, Morimura Y, Furuta T, Sugiyama H, Hagihara M, Uesugi M. A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA. J Am Chem Soc. 2016 Jul 27; 138(29):9037-40. PMID: 27410677.
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    7. Sakano D, Choi S, Kataoka M, Shiraki N, Uesugi M, Kume K, Kume S. Dopamine D2 Receptor-Mediated Regulation of Pancreatic ? Cell Mass. Stem Cell Reports. 2016 Jul 12; 7(1):95-109. PMID: 27373926; PMCID: PMC4944721.
    8. Biswas T, Akagi Y, Usuda K, Yasui K, Shimizu I, Okamoto M, Uesugi M, Hosokawa S, Nagasawa K. Synthesis of 24,24-Difluoro-1,3-cis-25-dihydroxy-19-norvitamin D3 Derivatives and Evaluation of Their Vitamin D Receptor-Binding Affinity. Biol Pharm Bull. 2016; 39(8):1387-91. PMID: 27476947.
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    9. Usuda K, Biswas T, Yamaguchi T, Akagi Y, Yasui K, Uesugi M, Shimizu I, Hosokawa S, Nagasawa K. Synthesis of Diastereomers of 1,3-cis-25-Dihydroxy-19-norvitamin D3. Chem Pharm Bull (Tokyo). 2016; 64(8):1190-5. PMID: 27477659.
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    10. Matsumoto Y, Ito A, Uesugi M, Kittaka A. Efficient N-Acyldopamine Synthesis. Chem Pharm Bull (Tokyo). 2016; 64(7):935-40. PMID: 27373649.
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    11. Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, Uesugi M. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23; 137(50):15859-64. PMID: 26630251.
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    12. Parvatkar P, Kato N, Uesugi M, Sato S, Ohkanda J. Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions. J Am Chem Soc. 2015 Dec 23; 137(50):15624-7. PMID: 26632868.
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    13. Sato S, Watanabe M, Katsuda Y, Murata A, Wang DO, Uesugi M. Live-cell imaging of endogenous mRNAs with a small molecule. Angew Chem Int Ed Engl. 2015 Feb 2; 54(6):1855-8. PMID: 25537455.
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    14. Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N, Uesugi M. Synthetic molecules that protect cells from anoikis and their use in cell transplantation. Angew Chem Int Ed Engl. 2014 Oct 13; 53(42):11208-13. PMID: 25196666.
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    15. Kuo TF, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M. Selective elimination of human pluripotent stem cells by a marine natural product derivative. J Am Chem Soc. 2014 Jul 16; 136(28):9798-801. PMID: 24992689.
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    16. Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M. A chemical probe that labels human pluripotent stem cells. Cell Rep. 2014 Mar 27; 6(6):1165-74. PMID: 24613351.
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    17. Yoshida T, Ozawa Y, Kimura T, Sato Y, Kuznetsov G, Xu S, Uesugi M, Agoulnik S, Taylor N, Funahashi Y, Matsui J. Eribulin mesilate suppresses experimental metastasis of breast cancer cells by reversing phenotype from epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET) states. Br J Cancer. 2014 Mar 18; 110(6):1497-505. PMID: 24569463; PMCID: PMC3960630.
    18. Araoka T, Mae S, Kurose Y, Uesugi M, Ohta A, Yamanaka S, Osafune K. Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods. PLoS One. 2014; 9(1):e84881. PMID: 24454758; PMCID: PMC3893162.
    19. Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S. VMAT2 identified as a regulator of late-stage ?-cell differentiation. Nat Chem Biol. 2014 Feb; 10(2):141-8. PMID: 24316738.
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    20. Kita M, Hirayama Y, Yoneda K, Yamagishi K, Chinen T, Usui T, Sumiya E, Uesugi M, Kigoshi H. Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A. J Am Chem Soc. 2013 Dec 4; 135(48):18089-95. PMID: 24228690.
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    21. Takemoto N, Suehara T, Frisco HL, Sato S, Sezaki T, Kusamori K, Kawazoe Y, Park SM, Yamazoe S, Mizuhata Y, Inoue R, Miller GJ, Hansen SU, Jayson GC, Gardiner JM, Kanaya T, Tokitoh N, Ueda K, Takakura Y, Kioka N, Nishikawa M, Uesugi M. Small-molecule-induced clustering of heparan sulfate promotes cell adhesion. J Am Chem Soc. 2013 Jul 31; 135(30):11032-9. PMID: 23822587.
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    22. Natsume A, Ito M, Katsushima K, Ohka F, Hatanaka A, Shinjo K, Sato S, Takahashi S, Ishikawa Y, Takeuchi I, Shimogawa H, Uesugi M, Okano H, Kim SU, Wakabayashi T, Issa JP, Sekido Y, Kondo Y. Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res. 2013 Jul 15; 73(14):4559-70. PMID: 23720055.
      View in: PubMed
    23. Kumagai H, Suemori H, Uesugi M, Nakatsuji N, Kawase E. Identification of small molecules that promote human embryonic stem cell self-renewal. Biochem Biophys Res Commun. 2013 May 17; 434(4):710-6. PMID: 23541943.
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    24. Jung D, Abu-Elheiga L, Ayuzawa R, Gu Z, Shirakawa T, Fujiki Y, Nakatsuji N, Wakil SJ, Uesugi M. Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule. Biochem J. 2012 Dec 15; 448(3):409-16. PMID: 23067267.
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    25. Minami I, Yamada K, Otsuji TG, Yamamoto T, Shen Y, Otsuka S, Kadota S, Morone N, Barve M, Asai Y, Tenkova-Heuser T, Heuser JE, Uesugi M, Aiba K, Nakatsuji N. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2012 Nov 29; 2(5):1448-60. PMID: 23103164.
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    26. Uesugi M. [Control and analysis of cells by synthetic small molecules]. Yakugaku Zasshi. 2012; 132(5):575-86. PMID: 22687693.
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    27. Khambu B, Uesugi M, Kawazoe Y. Translational repression stabilizes messenger RNA of autophagy-related genes. Genes Cells. 2011 Aug; 16(8):857-67. PMID: 21790910.
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    28. Kamisuki S, Shirakawa T, Kugimiya A, Abu-Elheiga L, Choo HY, Yamada K, Shimogawa H, Wakil SJ, Uesugi M. Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem. 2011 Jul 14; 54(13):4923-7. PMID: 21561152; PMCID: PMC3136361.
    29. Kawazoe Y, Shimogawa H, Sato A, Uesugi M. A mitochondrial surface-specific fluorescent probe activated by bioconversion. Angew Chem Int Ed Engl. 2011 Jun 6; 50(24):5478-81. PMID: 21542076.
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    30. Murata A, Sato S, Kawazoe Y, Uesugi M. Small-molecule fluorescent probes for specific RNA targets. Chem Commun (Camb). 2011 Apr 28; 47(16):4712-4. PMID: 21412566.
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    31. Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M, Nakatsuji N, Takahashi R. Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis. J Biomol Screen. 2011 Apr; 16(4):405-14. PMID: 21364087.
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    32. Sumiya E, Shimogawa H, Sasaki H, Tsutsumi M, Yoshita K, Ojika M, Suenaga K, Uesugi M. Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers. ACS Chem Biol. 2011 May 20; 6(5):425-31. PMID: 21322638.
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    33. Sato S, Murata A, Orihara T, Shirakawa T, Suenaga K, Kigoshi H, Uesugi M. Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. Chem Biol. 2011 Jan 28; 18(1):131-9. PMID: 21276946.
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    34. Shirakawa T, Kawazoe Y, Tsujikawa T, Jung D, Sato S, Uesugi M. Deactivation of STAT6 through serine 707 phosphorylation by JNK. J Biol Chem. 2011 Feb 4; 286(5):4003-10. PMID: 21123173; PMCID: PMC3030400.
    35. Murai R, Yoshida Y, Muraguchi T, Nishimoto E, Morioka Y, Kitayama H, Kondoh S, Kawazoe Y, Hiraoka M, Uesugi M, Noda M. A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. Oncotarget. 2010 Aug; 1(4):252-64. PMID: 21304177; PMCID: PMC3248105.
    36. Sato S, Murata A, Shirakawa T, Uesugi M. Biochemical target isolation for novices: affinity-based strategies. Chem Biol. 2010 Jun 25; 17(6):616-23. PMID: 20609411.
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    37. Hoshino M, Tsujimoto T, Yamazoe S, Uesugi M, Terada S. Adhesamine, a new synthetic molecule, accelerates differentiation and prolongs survival of primary cultured mouse hippocampal neurons. Biochem J. 2010 Apr 15; 427(2):297-304. PMID: 20146670.
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    38. Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009 Aug 28; 16(8):882-92. PMID: 19716478.
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    39. Yamazoe S, Shimogawa H, Sato S, Esko JD, Uesugi M. A dumbbell-shaped small molecule that promotes cell adhesion and growth. Chem Biol. 2009 Jul 31; 16(7):773-82. PMID: 19635414.
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    40. Jung D, Shimogawa H, Kwon Y, Mao Q, Sato S, Kamisuki S, Kigoshi H, Uesugi M. Wrenchnolol derivative optimized for gene activation in cells. J Am Chem Soc. 2009 Apr 8; 131(13):4774-82. PMID: 19290630.
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    41. Shinohara T, Uesugi M. [In-vivo activation of the p53 pathway by small-molecule antagonists of MDM2]. Tanpakushitsu Kakusan Koso. 2007 Oct; 52(13 Suppl):1816-7. PMID: 18051440.
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    42. Sato S, Murata A, Uesugi M. [Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography]. Tanpakushitsu Kakusan Koso. 2007 Oct; 52(13 Suppl):1782-3. PMID: 18051424.
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    43. Kamisuki S, Uesugi M. [Discovering high-affinity ligands for proteins: SAR by NMR]. Tanpakushitsu Kakusan Koso. 2007 Oct; 52(13 Suppl):1818-9. PMID: 18051441.
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    44. Kugimiya A, Takagi J, Uesugi M. [Role of LXRs in control of lipogenesis]. Tanpakushitsu Kakusan Koso. 2007 Oct; 52(13 Suppl):1814-5. PMID: 18051439.
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    45. Sato S, Kwon Y, Kamisuki S, Srivastava N, Mao Q, Kawazoe Y, Uesugi M. Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin. J Am Chem Soc. 2007 Jan 31; 129(4):873-80. PMID: 17243824.
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    46. Henderson YC, Frederick MJ, Jayakumar A, Choi Y, Wang MT, Kang Y, Evans R, Spring PM, Uesugi M, Clayman GL. Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3. Placenta. 2007 Feb-Mar; 28(2-3):152-60. PMID: 16730372.
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    47. Jung D, Choi Y, Uesugi M. Small organic molecules that modulate gene transcription. Drug Discov Today. 2006 May; 11(9-10):452-7. PMID: 16635809.
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    48. Choi Y, Shimogawa H, Murakami K, Ramdas L, Zhang W, Qin J, Uesugi M. Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2. Chem Biol. 2006 Mar; 13(3):241-9. PMID: 16638529.
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    49. Sato A, Kawazoe Y, Kamisuki S, Uesugi M. Synthesis of synthetic small molecule transcription factors (STF). Nucleic Acids Symp Ser (Oxf). 2006; (50):29-30. PMID: 17150801.
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    50. Uesugi M. [Small molecules that control gene expression]. Seikagaku. 2005 Sep; 77(9):1177-80. PMID: 16241004.
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    51. Kawazoe Y, Uesugi M. [Trends in chemical libraries for chemical genetics]. Tanpakushitsu Kakusan Koso. 2005 Aug; 50(9):1043-8. PMID: 16083041.
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    52. Kwon Y, Arndt HD, Mao Q, Choi Y, Kawazoe Y, Dervan PB, Uesugi M. Small molecule transcription factor mimic. J Am Chem Soc. 2004 Dec 15; 126(49):15940-1. PMID: 15584709.
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    53. Uesugi M. Synthetic molecules that modulate transcription and differentiation: hints for future drug discovery. Comb Chem High Throughput Screen. 2004 Nov; 7(7):653-9. PMID: 15578927.
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    54. Kawazoe Y, Tanaka S, Uesugi M. Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis. Chem Biol. 2004 Jul; 11(7):907-13. PMID: 15271349.
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    55. Shimogawa H, Kwon Y, Mao Q, Kawazoe Y, Choi Y, Asada S, Kigoshi H, Uesugi M. A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction. J Am Chem Soc. 2004 Mar 24; 126(11):3461-71. PMID: 15025473.
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    56. Asada S, Choi Y, Uesugi M. A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction. J Am Chem Soc. 2003 Apr 30; 125(17):4992-3. PMID: 12708845.
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    57. Choi Y, Kawazoe Y, Murakami K, Misawa H, Uesugi M. Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem. 2003 Feb 28; 278(9):7320-4. PMID: 12496288.
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    58. Jabbur JR, Tabor AD, Cheng X, Wang H, Uesugi M, Lozano G, Zhang W. Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. Oncogene. 2002 Oct 10; 21(46):7100-13. PMID: 12370832.
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    59. Asada S, Choi Y, Yamada M, Wang SC, Hung MC, Qin J, Uesugi M. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20):12747-52. PMID: 12242338; PMCID: PMC130531.
    60. Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J. Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. J Biol Chem. 2001 Mar 23; 276(12):8734-9. PMID: 11118440.
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    61. Park S, Uesugi M, Verdine GL. A second calcineurin binding site on the NFAT regulatory domain. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7130-5. PMID: 10860980; PMCID: PMC16511.
    62. Choi Y, Asada S, Uesugi M. Divergent hTAFII31-binding motifs hidden in activation domains. J Biol Chem. 2000 May 26; 275(21):15912-6. PMID: 10821850.
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    63. Uesugi M, Verdine GL. The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14801-6. PMID: 10611293; PMCID: PMC24728.
    64. Nyanguile O, Uesugi M, Austin DJ, Verdine GL. A nonnatural transcriptional coactivator. Proc Natl Acad Sci U S A. 1997 Dec 9; 94(25):13402-6. PMID: 9391036; PMCID: PMC28316.
    65. Uesugi M, Nyanguile O, Lu H, Levine AJ, Verdine GL. Induced alpha helix in the VP16 activation domain upon binding to a human TAF. Science. 1997 Aug 29; 277(5330):1310-3. PMID: 9271577.
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    66. Kusakabe T, Uesugi M, Sugiura Y. Sequence preference for strand cleavage of gapped duplexes by dynemicin A: possible mechanism of sequence-dependent double-stranded breaks. Biochemistry. 1995 Aug 8; 34(31):9944-50. PMID: 7632693.
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    67. Uesugi M, Kusakabe T, Sugiura Y. Hydrophobic DNA binding of esperamicin requires conformational distortion of the host DNA. Biochim Biophys Acta. 1995 Mar 14; 1261(1):99-106. PMID: 7893766.
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    68. Totsuka R, Aizawa Y, Uesugi M, Okuno Y, Matsumoto T, Sugiura Y. RNA cleavage by C-1027 chromophore, an enediyne antitumor antibiotic: high selectivity to an anticodon arm. Biochem Biophys Res Commun. 1995 Mar 8; 208(1):168-73. PMID: 7887925.
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    69. Kusakabe T, Maekawa K, Ichikawa A, Uesugi M, Sugiura Y. Conformation-selective DNA strand breaks by dynemicin: a molecular wedge into flexible regions of DNA. Biochemistry. 1993 Nov 2; 32(43):11669-75. PMID: 8218234.
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    70. Uesugi M, Sugiura Y. New insights into sequence recognition process of esperamicin A1 and calicheamicin gamma 1I.: origin of their selectivities and "induced fit" mechanism. Biochemistry. 1993 May 4; 32(17):4622-7. PMID: 8485139.
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    71. Uesugi M, Kusakabe T, Sugiura Y. Induced-fit association between DNA and esperamicin. Importance of structural flexibility in host DNA duplex. Nucleic Acids Symp Ser. 1993; (29):89-90. PMID: 8247807.
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    72. Shiraki T, Uesugi M, Sugiura Y. C-1' hydrogen abstraction of deoxyribose in DNA strand scission by dynemicin A. Biochem Biophys Res Commun. 1992 Oct 30; 188(2):584-9. PMID: 1280117.
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    73. Uesugi M, Sugiura Y. Product analyses in DNA strand scission by antitumor antibiotic elsamicin A. Biochem Biophys Res Commun. 1992 Jul 15; 186(1):580-7. PMID: 1321617.
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    74. Uesugi M, Sugiura Y. DNA cleaving modes in minor groove of DNA helix by esperamicin and calicheamicin antitumor antibiotics. Nucleic Acids Symp Ser. 1992; (27):1-2. PMID: 1289776.
      View in: PubMed
    75. Uesugi M, Sekida T, Matsuki S, Sugiura Y. Selective DNA cleavage by elsamicin A and switch function of its amino sugar group. Biochemistry. 1991 Jul 9; 30(27):6711-5. PMID: 1648389.
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    76. Sugiura Y, Arakawa T, Uesugi M, Shiraki T, Ohkuma H, Konishi M. Reductive and nucleophilic activation products of dynemicin A with methyl thioglycolate. A rational mechanism for DNA cleavage of the thiol-activated dynemicin A. Biochemistry. 1991 Mar 26; 30(12):2989-92. PMID: 2007134.
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    77. Uesugi M, Sugiura Y. Switch-function of amino sugar on elsamicin A, a DNA binding antitumor antibiotic. Nucleic Acids Symp Ser. 1990; (22):33-4. PMID: 2101907.
      View in: PubMed
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