Last Name


TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
DivisionSurgery-Surgical Research
AddressOne Baylor Plaza
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology

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    Characterization of the function of DNA-repair proteins in tumor suppression using both knockout mouse models and clinical specimens

    BRIT1/MCPH1 knockout mice have been generated in the lab and BRIT1’s role in the suppression of breast, liver, and pancreatic cancer is studied extensively using the unique knockout mouse model, as well as clinical specimens.

    Development of cancer-specific therapies by targeting DNA repair deficiency in cancer
    We use a synthetic lethality approach and combination therapy to develop more effective treatments for breast and liver cancer.

    Identification of novel genes that drive breast and liver cancer development
    Using a bio-informatics approach, we select candidate genes analyzing The Cancer Genome Atlas (TCGA) data and we characterize the genuine functions of these candidate genes in vitro and in animal models.

    Collapse keywords
    • Breast cancer
    • DNA damage response pathways
    • DNA repair
    • Knockout mouse model
    • Liver cancer
    • Pancreatic cancer
    • Synthetic lethality
    • Targeted cancer therapy
    • Tumor Suppressor

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kim JA, Tan Y, Wang X, Cao X, Veeraraghavan J, Liang Y, Edwards DP, Huang S, Pan X, Li K, Schiff R, Wang XS. Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers. Nat Commun. 2016 Oct 03; 7:12991. PMID: 27694828.
      View in: PubMed
    2. Mo W, Liu Q, Lin CC, Dai H, Peng Y, Liang Y, Peng G, Meric-Bernstam F, Mills GB, Li K, Lin SY. mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer. Clin Cancer Res. 2016 Apr 1; 22(7):1699-712. PMID: 26546619; PMCID: PMC4858320.
    3. Liang Y, Gao H, Lin SY, Goss JA, Du C, Li K. Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model. Oncogene. 2015 Aug 13; 34(33):4368-78. PMID: 25362854; PMCID: PMC4417661.
    4. Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T, Sofat R, Stender S, Johnson PC, Scott RA, Leusink M, Verweij N, Sharp SJ, Guo Y, Giambartolomei C, Chung C, Peasey A, Amuzu A, Li K, Palmen J, Howard P, Cooper JA, Drenos F, Li YR, Lowe G, Gallacher J, Stewart MC, Tzoulaki I, Buxbaum SG, van der A DL, Forouhi NG, Onland-Moret NC, van der Schouw YT, Schnabel RB, Hubacek JA, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Stepaniak U, Malyutina S, Baldassarre D, Sennblad B, Tremoli E, de Faire U, Veglia F, Ford I, Jukema JW, Westendorp RG, de Borst GJ, de Jong PA, Algra A, Spiering W, Maitland-van der Zee AH, Klungel OH, de Boer A, Doevendans PA, Eaton CB, Robinson JG, Duggan D. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet. 2015 Jan 24; 385(9965):351-61. PMID: 25262344; PMCID: PMC4322187.
    5. Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang ZZ, Bizon C, Lange EM, Smith JD, Turner EH, Jun G, Kang HM, Peloso G, Auer P, Li KP, Flannick J, Zhang J, Fuchsberger C, Gaulton K, Lindgren C, Locke A, Manning A, Sim X, Rivas MA, Holmen OL, Gottesman O, Lu Y, Ruderfer D, Stahl EA, Duan Q, Li Y, Durda P, Jiao S, Isaacs A, Hofman A, Bis JC, Correa A, Griswold ME, Jakobsdottir J, Smith AV, Schreiner PJ, Feitosa MF, Zhang Q, Huffman JE, Crosby J, Wassel CL, Do R, Franceschini N, Martin LW, Robinson JG, Assimes TL, Crosslin DR, Rosenthal EA, Tsai M, Rieder MJ, Farlow DN, Folsom AR, Lumley T, Fox ER, Carlson CS, Peters U, Jackson RD, van Duijn CM, Uitterlinden AG, Levy D, Rotter JI, Taylor HA, Gudnason V, Siscovick DS, Fornage M, Borecki IB, Hayward C, Rudan I, Chen YE, Bottinger EP, Loos RJ, Sætrom P, Hveem K, Boehnke M, Groop L, McCarthy M, Meitinger T, Ballantyne CM, Gabriel SB, O'Donnell CJ, Post WS, North KE, Reiner AP, Boerwinkle E, Psaty BM, Altshuler D, Kathiresan S, Lin DY, Jarvik GP, Cupples LA, Kooperberg C, Wilson JG, Nickerson DA, Abecasis GR, Rich SS, Tracy RP, Willer CJ. Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet. 2014 Feb 6; 94(2):233-45. PMID: 24507775; PMCID: PMC3928660.
    6. Bhatnagar P, Li Z, Choi Y, Guo J, Li F, Lee DY, Figliola M, Huls H, Lee DA, Zal T, Li KC, Cooper LJ. Imaging of genetically engineered T cells by PET using gold nanoparticles complexed to Copper-64. Integr Biol (Camb). 2013 Jan; 5(1):231-8. PMID: 23034721; PMCID: PMC3713485.
    7. Pan MR, Hsieh HJ, Dai H, Hung WC, Li K, Peng G, Lin SY. Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment. J Biol Chem. 2012 Feb 24; 287(9):6764-72. PMID: 22219182; PMCID: PMC3307306.
    8. Hu R, Peng G, Dai H, Breuer EK, Stemke-Hale K, Li K, Gonzalez-Angulo AM, Mills GB, Lin SY. ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. Cancer Res. 2011 Oct 15; 71(20):6524-34. PMID: 21852383; PMCID: PMC3193577.
    9. Liang Y, Gao H, Lin SY, Goss JA, Brunicardi FC, Li K. siRNA-based targeting of cyclin E overexpression inhibits breast cancer cell growth and suppresses tumor development in breast cancer mouse model. PLoS One. 2010; 5(9):e12860. PMID: 20877462; PMCID: PMC2942895.
    10. Yang T, Mendoza-Londono R, Lu H, Tao J, Li K, Keller B, Jiang MM, Shah R, Chen Y, Bertin TK, Engin F, Dabovic B, Rifkin DB, Hicks J, Jamrich M, Beaudet AL, Lee B. E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J Clin Invest. 2010 Jul; 120(7):2474-85. PMID: 20530870; PMCID: PMC2898604.
    11. Lin SY, Liang Y, Li K. Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression. Yonsei Med J. 2010 May; 51(3):295-301. PMID: 20376879; PMCID: PMC2852782.
    12. Liang Y, Gao H, Lin SY, Peng G, Huang X, Zhang P, Goss JA, Brunicardi FC, Multani AS, Chang S, Li K. BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet. 2010 Jan; 6(1):e1000826. PMID: 20107607; PMCID: PMC2809772.
    13. Angelini P, Walmsley R, Cheong BY, Ott DA. Left main coronary artery originating from the proper sinus but with acute angulation and an intramural course, leading to critical stenosis. Tex Heart Inst J. 2010; 37(2):221-5. PMID: 20401300; PMCID: PMC2851442.
    14. Liang Y, Lin SY, Brunicardi FC, Goss J, Li K. DNA damage response pathways in tumor suppression and cancer treatment. World J Surg. 2009 Apr; 33(4):661-6. PMID: 19034564.
      View in: PubMed
    15. Zhang N, Kuznetsov SG, Sharan SK, Li K, Rao PH, Pati D. A handcuff model for the cohesin complex. J Cell Biol. 2008 Dec 15; 183(6):1019-31. PMID: 19075111; PMCID: PMC2600748.
    16. Klemmer P, Smit AB, Li KW. Proteomics analysis of immuno-precipitated synaptic protein complexes. J Proteomics. 2009 Feb 15; 72(1):82-90. PMID: 19022416.
      View in: PubMed
    17. Chaplet M, Rai R, Jackson-Bernitsas D, Li K, Lin SY. BRIT1/MCPH1: a guardian of genome and an enemy of tumors. Cell Cycle. 2006 Nov; 5(22):2579-83. PMID: 17172830.
      View in: PubMed
    18. Angelini P, Walmsley RP, Libreros A, Ott DA. Symptomatic anomalous origination of the left coronary artery from the opposite sinus of valsalva. Clinical presentations, diagnosis, and surgical repair. Tex Heart Inst J. 2006; 33(2):171-9. PMID: 16878619; PMCID: PMC1524694.
    19. Lin SY, Li K, Stewart GS, Elledge SJ. Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6484-9. PMID: 15096610; PMCID: PMC404071.
    20. Li K, Lin SY, Brunicardi FC, Seu P. Use of RNA interference to target cyclin E-overexpressing hepatocellular carcinoma. Cancer Res. 2003 Jul 1; 63(13):3593-7. PMID: 12839946.
      View in: PubMed
    21. Li K, Ramirez MA, Rose E, Beaudet AL. A gene fusion method to screen for regulatory effects on gene expression: application to the LDL receptor. Hum Mol Genet. 2002 Dec 15; 11(26):3257-65. PMID: 12471052.
      View in: PubMed
    22. Tari AM, Hung MC, Li K, Lopez-Berestein G. Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells. Oncogene. 1999 Feb 11; 18(6):1325-32. PMID: 10022814.
      View in: PubMed
    23. Cox KJ, Tensen CP, Van der Schors RC, Li KW, van Heerikhuizen H, Vreugdenhil E, Geraerts WP, Burke JF. Cloning, characterization, and expression of a G-protein-coupled receptor from Lymnaea stagnalis and identification of a leucokinin-like peptide, PSFHSWSamide, as its endogenous ligand. J Neurosci. 1997 Feb 15; 17(4):1197-205. PMID: 9006965.
      View in: PubMed
    24. van Golen FA, Li KW, de Lange RP, Jespersen S, Geraerts WP. Mutually exclusive neuronal expression of peptides encoded by the FMRFa gene underlies a differential control of copulation in Lymnaea. J Biol Chem. 1995 Nov 24; 270(47):28487-93. PMID: 7499356.
      View in: PubMed
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