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NANCY R WEBB

TitleClinical Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Ophthalmology
DivisionOphthalmology
AddressOne Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schewe M, Franken PF, Sacchetti A, Schmitt M, Joosten R, Böttcher R, van Royen ME, Jeammet L, Payré C, Scott PM, Webb NR, Gelb M, Cormier RT, Lambeau G, Fodde R. Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer. Cell Stem Cell. 2016 Jul 7; 19(1):38-51. PMID: 27292189.
      View in: PubMed
    2. Kim MH, de Beer MC, Wroblewski JM, Charnigo RJ, Ji A, Webb NR, de Beer FC, van der Westhuyzen DR. Impact of individual acute phase serum amyloid A isoforms on HDL metabolism in mice. J Lipid Res. 2016 Jun; 57(6):969-79. PMID: 27018443; PMCID: PMC4878182 [Available on 06/01/17].
    3. Rosenson RS, Brewer HB, Ansell BJ, Barter P, Chapman MJ, Heinecke JW, Kontush A, Tall AR, Webb NR. Dysfunctional HDL and atherosclerotic cardiovascular disease. Nat Rev Cardiol. 2016 Jan; 13(1):48-60. PMID: 26323267.
      View in: PubMed
    4. Webb NR, De Beer MC, Wroblewski JM, Ji A, Bailey W, Shridas P, Charnigo RJ, Noffsinger VP, Witta J, Howatt DA, Balakrishnan A, Rateri DL, Daugherty A, De Beer FC. Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1156-65. PMID: 25745063; PMCID: PMC4823018.
    5. Layne JD, Shridas P, Webb NR. Ectopically expressed pro-group X secretory phospholipase A2 is proteolytically activated in mouse adrenal cells by furin-like proprotein convertases: implications for the regulation of adrenal steroidogenesis. J Biol Chem. 2015 Mar 20; 290(12):7851-60. PMID: 25623068; PMCID: PMC4367284.
    6. Thompson JC, Jayne C, Thompson J, Wilson PG, Yoder MH, Webb N, Tannock LR. A brief elevation of serum amyloid A is sufficient to increase atherosclerosis. J Lipid Res. 2015 Feb; 56(2):286-93. PMID: 25429103; PMCID: PMC4306683.
    7. Shridas P, Zahoor L, Forrest KJ, Layne JD, Webb NR. Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism. J Biol Chem. 2014 Oct 3; 289(40):27410-7. PMID: 25122761; PMCID: PMC4183781.
    8. Ji A, Wroblewski JM, Webb NR, van der Westhuyzen DR. Impact of phospholipid transfer protein on nascent high-density lipoprotein formation and remodeling. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1910-6. PMID: 25060793; PMCID: PMC4141034.
    9. De Beer MC, Wroblewski JM, Noffsinger VP, Rateri DL, Howatt DA, Balakrishnan A, Ji A, Shridas P, Thompson JC, van der Westhuyzen DR, Tannock LR, Daugherty A, Webb NR, De Beer FC. Deficiency of endogenous acute phase serum amyloid A does not affect atherosclerotic lesions in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2014 Feb; 34(2):255-61. PMID: 24265416; PMCID: PMC3951741.
    10. Rosenson RS, Brewer HB, Ansell B, Barter P, Chapman MJ, Heinecke JW, Kontush A, Tall AR, Webb NR. Translation of high-density lipoprotein function into clinical practice: current prospects and future challenges. Circulation. 2013 Sep 10; 128(11):1256-67. PMID: 24019446.
      View in: PubMed
    11. de Beer MC, Wroblewski JM, Noffsinger VP, Ji A, Meyer JM, van der Westhuyzen DR, de Beer FC, Webb NR. The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A. J Lipids. 2013; 2013:283486. PMID: 23431457; PMCID: PMC3572687.
    12. Kim MH, de Beer MC, Wroblewski JM, Webb NR, de Beer FC. SAA does not induce cytokine production in physiological conditions. Cytokine. 2013 Feb; 61(2):506-12. PMID: 23165195; PMCID: PMC3616876.
    13. Boyanovsky BB, Bailey W, Dixon L, Shridas P, Webb NR. Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice. Am J Pathol. 2012 Sep; 181(3):1088-98. PMID: 22813854; PMCID: PMC3432434.
    14. Ji A, Wroblewski JM, Cai L, de Beer MC, Webb NR, van der Westhuyzen DR. Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI. J Lipid Res. 2012 Mar; 53(3):446-55. PMID: 22190590; PMCID: PMC3276468.
    15. Wroblewski JM, Jahangiri A, Ji A, de Beer FC, van der Westhuyzen DR, Webb NR. Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase. J Lipid Res. 2011 Dec; 52(12):2255-61. PMID: 21957202; PMCID: PMC3220292.
    16. Shridas P, Bailey WM, Talbott KR, Oslund RC, Gelb MH, Webb NR. Group X secretory phospholipase A2 enhances TLR4 signaling in macrophages. J Immunol. 2011 Jul 1; 187(1):482-9. PMID: 21622863; PMCID: PMC3119755.
    17. Ji A, Meyer JM, Cai L, Akinmusire A, de Beer MC, Webb NR, van der Westhuyzen DR. Scavenger receptor SR-BI in macrophage lipid metabolism. Atherosclerosis. 2011 Jul; 217(1):106-12. PMID: 21481393; PMCID: PMC3139003.
    18. de Beer MC, Ji A, Jahangiri A, Vaughan AM, de Beer FC, van der Westhuyzen DR, Webb NR. ATP binding cassette G1-dependent cholesterol efflux during inflammation. J Lipid Res. 2011 Feb; 52(2):345-53. PMID: 21138980; PMCID: PMC3023555.
    19. Shridas P, Bailey WM, Gizard F, Oslund RC, Gelb MH, Bruemmer D, Webb NR. Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):2014-21. PMID: 20844270; PMCID: PMC2958102.
    20. Zack M, Boyanovsky BB, Shridas P, Bailey W, Forrest K, Howatt DA, Gelb MH, de Beer FC, Daugherty A, Webb NR. Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice. Atherosclerosis. 2011 Jan; 214(1):58-64. PMID: 20833395; PMCID: PMC3005558.
    21. de Beer MC, Webb NR, Wroblewski JM, Noffsinger VP, Rateri DL, Ji A, van der Westhuyzen DR, de Beer FC. Impact of serum amyloid A on high density lipoprotein composition and levels. J Lipid Res. 2010 Nov; 51(11):3117-25. PMID: 20667817; PMCID: PMC2952552.
    22. Li X, Shridas P, Forrest K, Bailey W, Webb NR. Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models. FASEB J. 2010 Nov; 24(11):4313-24. PMID: 20585029; PMCID: PMC2974424.
    23. Shridas P, Bailey WM, Boyanovsky BB, Oslund RC, Gelb MH, Webb NR. Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands. J Biol Chem. 2010 Jun 25; 285(26):20031-9. PMID: 20421306; PMCID: PMC2888415.
    24. Boyanovsky BB, Li X, Shridas P, Sunkara M, Morris AJ, Webb NR. Bioactive products generated by group V sPLA(2) hydrolysis of LDL activate macrophages to secrete pro-inflammatory cytokines. Cytokine. 2010 Apr; 50(1):50-7. PMID: 20138782; PMCID: PMC2850046.
    25. de Beer MC, Webb NR, Whitaker NL, Wroblewski JM, Jahangiri A, van der Westhuyzen DR, de Beer FC. SR-BI selective lipid uptake: subsequent metabolism of acute phase HDL. Arterioscler Thromb Vasc Biol. 2009 Sep; 29(9):1298-303. PMID: 19304574; PMCID: PMC2754709.
    26. Boyanovsky B, Zack M, Forrest K, Webb NR. The capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivo. Arterioscler Thromb Vasc Biol. 2009 Apr; 29(4):532-8. PMID: 19164803; PMCID: PMC2782483.
    27. Boyanovsky BB, Shridas P, Simons M, van der Westhuyzen DR, Webb NR. Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL. J Lipid Res. 2009 Apr; 50(4):641-50. PMID: 19056705; PMCID: PMC2656657.
    28. Jahangiri A, de Beer MC, Noffsinger V, Tannock LR, Ramaiah C, Webb NR, van der Westhuyzen DR, de Beer FC. HDL remodeling during the acute phase response. Arterioscler Thromb Vasc Biol. 2009 Feb; 29(2):261-7. PMID: 19008529; PMCID: PMC2760005.
    29. Wilson PG, Thompson JC, Webb NR, de Beer FC, King VL, Tannock LR. Serum amyloid A, but not C-reactive protein, stimulates vascular proteoglycan synthesis in a pro-atherogenic manner. Am J Pathol. 2008 Dec; 173(6):1902-10. PMID: 18974302; PMCID: PMC2626400.
    30. Boyanovsky BB, Webb NR. Biology of secretory phospholipase A2. Cardiovasc Drugs Ther. 2009 Feb; 23(1):61-72. PMID: 18853244.
      View in: PubMed
    31. Webb NR. Getting to the core of atherosclerosis. Nat Med. 2008 Oct; 14(10):1015-6. PMID: 18841134.
      View in: PubMed
    32. Webb NR, Moore KJ. Macrophage-derived foam cells in atherosclerosis: lessons from murine models and implications for therapy. Curr Drug Targets. 2007 Dec; 8(12):1249-63. PMID: 18220702.
      View in: PubMed
    33. Sun B, Boyanovsky BB, Connelly MA, Shridas P, van der Westhuyzen DR, Webb NR. Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI. J Lipid Res. 2007 Dec; 48(12):2560-70. PMID: 17876058.
      View in: PubMed
    34. van der Westhuyzen DR, de Beer FC, Webb NR. HDL cholesterol transport during inflammation. Curr Opin Lipidol. 2007 Apr; 18(2):147-51. PMID: 17353662.
      View in: PubMed
    35. Bostrom MA, Boyanovsky BB, Jordan CT, Wadsworth MP, Taatjes DJ, de Beer FC, Webb NR. Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice. Arterioscler Thromb Vasc Biol. 2007 Mar; 27(3):600-6. PMID: 17204667.
      View in: PubMed
    36. de Beer FC, Webb NR. Inflammation and atherosclerosis: Group IIa and Group V sPLA2 are not redundant. Arterioscler Thromb Vasc Biol. 2006 Jul; 26(7):1421-2. PMID: 16794232.
      View in: PubMed
    37. Sun B, Eckhardt ER, Shetty S, van der Westhuyzen DR, Webb NR. Quantitative analysis of SR-BI-dependent HDL retroendocytosis in hepatocytes and fibroblasts. J Lipid Res. 2006 Aug; 47(8):1700-13. PMID: 16705213.
      View in: PubMed
    38. Eckhardt ER, Cai L, Shetty S, Zhao Z, Szanto A, Webb NR, Van der Westhuyzen DR. High density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif. J Biol Chem. 2006 Feb 17; 281(7):4348-53. PMID: 16368683.
      View in: PubMed
    39. de Beer MC, van der Westhuyzen DR, Whitaker NL, Webb NR, de Beer FC. SR-BI-mediated selective lipid uptake segregates apoA-I and apoA-II catabolism. J Lipid Res. 2005 Oct; 46(10):2143-50. PMID: 16061955.
      View in: PubMed
    40. Boyanovsky BB, van der Westhuyzen DR, Webb NR. Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans. J Biol Chem. 2005 Sep 23; 280(38):32746-52. PMID: 16040605.
      View in: PubMed
    41. Daugherty A, Webb NR, Rateri DL, King VL. Thematic review series: The immune system and atherogenesis. Cytokine regulation of macrophage functions in atherogenesis. J Lipid Res. 2005 Sep; 46(9):1812-22. PMID: 15995168.
      View in: PubMed
    42. Webb NR. Secretory phospholipase A2 enzymes in atherogenesis. Curr Opin Lipidol. 2005 Jun; 16(3):341-4. PMID: 15891396.
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    43. Out R, Hoekstra M, de Jager SC, de Vos P, van der Westhuyzen DR, Webb NR, Van Eck M, Biessen EA, Van Berkel TJ. Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice. J Lipid Res. 2005 Jun; 46(6):1172-81. PMID: 15772431.
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    44. Webb NR, de Beer MC, Asztalos BF, Whitaker N, van der Westhuyzen DR, de Beer FC. Remodeling of HDL remnants generated by scavenger receptor class B type I. J Lipid Res. 2004 Sep; 45(9):1666-73. PMID: 15210842.
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    45. Wooton-Kee CR, Boyanovsky BB, Nasser MS, de Villiers WJ, Webb NR. Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation. Arterioscler Thromb Vasc Biol. 2004 Apr; 24(4):762-7. PMID: 14962950.
      View in: PubMed
    46. Eckhardt ER, Cai L, Sun B, Webb NR, van der Westhuyzen DR. High density lipoprotein uptake by scavenger receptor SR-BII. J Biol Chem. 2004 Apr 2; 279(14):14372-81. PMID: 14726519.
      View in: PubMed
    47. Cabana VG, Feng N, Reardon CA, Lukens J, Webb NR, de Beer FC, Getz GS. Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro. J Lipid Res. 2004 Feb; 45(2):317-25. PMID: 14595002.
      View in: PubMed
    48. Webb NR, de Beer MC, de Beer FC, van der Westhuyzen DR. ApoB-containing lipoproteins in apoE-deficient mice are not metabolized by the class B scavenger receptor BI. J Lipid Res. 2004 Feb; 45(2):272-80. PMID: 14563829.
      View in: PubMed
    49. Webb NR, Bostrom MA, Szilvassy SJ, van der Westhuyzen DR, Daugherty A, de Beer FC. Macrophage-expressed group IIA secretory phospholipase A2 increases atherosclerotic lesion formation in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2003 Feb 1; 23(2):263-8. PMID: 12588769.
      View in: PubMed
    50. de Beer MC, Zhao Z, Webb NR, van der Westhuyzen DR, de Villiers WJ. Lack of a direct role for macrosialin in oxidized LDL metabolism. J Lipid Res. 2003 Apr; 44(4):674-85. PMID: 12562841.
      View in: PubMed
    51. Webb NR, Cai L, Ziemba KS, Yu J, Kindy MS, van der Westhuyzen DR, de Beer FC. The fate of HDL particles in vivo after SR-BI-mediated selective lipid uptake. J Lipid Res. 2002 Nov; 43(11):1890-8. PMID: 12401888.
      View in: PubMed
    52. Webb NR, de Beer MC, Yu J, Kindy MS, Daugherty A, van der Westhuyzen DR, de Beer FC. Overexpression of SR-BI by adenoviral vector promotes clearance of apoA-I, but not apoB, in human apoB transgenic mice. J Lipid Res. 2002 Sep; 43(9):1421-8. PMID: 12235173.
      View in: PubMed
    53. de Villiers WJ, Cai L, Webb NR, de Beer MC, van der Westhuyzen DR, de Beer FC. CD36 does not play a direct role in HDL or LDL metabolism. J Lipid Res. 2001 Aug; 42(8):1231-8. PMID: 11483624.
      View in: PubMed
    54. de Beer MC, Durbin DM, Cai L, Mirocha N, Jonas A, Webb NR, de Beer FC, van Der Westhuyzen DR. Apolipoprotein A-II modulates the binding and selective lipid uptake of reconstituted high density lipoprotein by scavenger receptor BI. J Biol Chem. 2001 May 11; 276(19):15832-9. PMID: 11279034.
      View in: PubMed
    55. de Beer FC, Connell PM, Yu J, de Beer MC, Webb NR, van der Westhuyzen DR. HDL modification by secretory phospholipase A(2) promotes scavenger receptor class B type I interaction and accelerates HDL catabolism. J Lipid Res. 2000 Nov; 41(11):1849-57. PMID: 11060355.
      View in: PubMed
    56. Hosoai H, Webb NR, Glick JM, Tietge UJ, Purdom MS, de Beer FC, Rader DJ. Expression of serum amyloid A protein in the absence of the acute phase response does not reduce HDL cholesterol or apoA-I levels in human apoA-I transgenic mice. J Lipid Res. 1999 Apr; 40(4):648-53. PMID: 10191288.
      View in: PubMed
    57. Webb NR, Connell PM, Graf GA, Smart EJ, de Villiers WJ, de Beer FC, van der Westhuyzen DR. SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells. J Biol Chem. 1998 Jun 12; 273(24):15241-8. PMID: 9614139.
      View in: PubMed
    58. Hogstrand C, Webb N, Wood CM. Covariation in regulation of affinity for branchial zinc and calcium uptake in freshwater rainbow trout. J Exp Biol. 1998 Jun; 201(Pt 11):1809-15. PMID: 9576891.
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    59. Welch CL, Xia YR, Gu LJ, Machleder D, Mehrabian M, Wen PZ, Webb N, de Villiers WJ, van der Westhuyzen D, Lusis AJ. Srb1 maps to mouse chromosome 5 in a region harboring putative QTLs for plasma lipoprotein levels. Mamm Genome. 1997 Dec; 8(12):942-4. PMID: 9383292.
      View in: PubMed
    60. Webb NR, de Beer MC, van der Westhuyzen DR, Kindy MS, Banka CL, Tsukamoto K, Rader DL, de Beer FC. Adenoviral vector-mediated overexpression of serum amyloid A in apoA-I-deficient mice. J Lipid Res. 1997 Aug; 38(8):1583-90. PMID: 9300780.
      View in: PubMed
    61. Webb NR, de Villiers WJ, Connell PM, de Beer FC, van der Westhuyzen DR. Alternative forms of the scavenger receptor BI (SR-BI). J Lipid Res. 1997 Jul; 38(7):1490-5. PMID: 9254074.
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    62. de Beer MC, de Beer FC, Gerardot CJ, Cecil DR, Webb NR, Goodson ML, Kindy MS. Structure of the mouse Saa4 gene and its linkage to the serum amyloid A gene family. Genomics. 1996 May 15; 34(1):139-42. PMID: 8661036.
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    63. Bascom CC, Wolfshohl JR, Coffey RJ, Madisen L, Webb NR, Purchio AR, Derynck R, Moses HL. Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2. Mol Cell Biol. 1989 Dec; 9(12):5508-15. PMID: 2586525; PMCID: PMC363721.
    64. Webb NR, Madisen L, Rose TM, Purchio AF. Structural and sequence analysis of TGF-beta 2 cDNA clones predicts two different precursor proteins produced by alternative mRNA splicing. DNA. 1988 Sep; 7(7):493-7. PMID: 2850146.
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    65. Gentry LE, Webb NR, Lim GJ, Brunner AM, Ranchalis JE, Twardzik DR, Lioubin MN, Marquardt H, Purchio AF. Type 1 transforming growth factor beta: amplified expression and secretion of mature and precursor polypeptides in Chinese hamster ovary cells. Mol Cell Biol. 1987 Oct; 7(10):3418-27. PMID: 3479680; PMCID: PMC367992.
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