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JEFFREY M ROSEN

TitleDistinguished Service Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Endocrinology


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    1996Marc Dresden Excellence in Graduate Education Award, Baylor College of Medicine
    2000Edwin B Astwood Lecture Award, Endocrine Society
    2002Barbara & Corbin J. Robertson, Jr. Presidential Award for Excellence in Education, Baylor College of Medicine
    2004Michael E. DeBakey Excellence in Research Award, Baylor College of Medicine
    2010Susan G. Komen for the Cure Brinker Basic Science Award, Komen Foundation
    2016AAAS Fellow, American Association for the Advancement of Science

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhang M, Lee AV, Rosen JM. The Cellular Origin and Evolution of Breast Cancer. Cold Spring Harb Perspect Med. 2017 Jan 06. PMID: 28062556.
      View in: PubMed
    2. Welte T, Zhang XH, Rosen JM. Repurposing Antiestrogens for Tumor Immunotherapy. Cancer Discov. 2017 Jan; 7(1):17-19. PMID: 28062672.
      View in: PubMed
    3. Welte T, Rosen JM, Zhang XH. Fatal attraction: TICs and MDSCs. Cell Cycle. 2016 Oct; 15(19):2545-2546. PMID: 27574951.
      View in: PubMed
    4. Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Erratum: Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 Jun 28; 18(7):822. PMID: 27350446.
      View in: PubMed
    5. Toneff MJ, Sreekumar A, Tinnirello A, Hollander PD, Habib S, Li S, Ellis MJ, Xin L, Mani SA, Rosen JM. The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. BMC Biol. 2016; 14(1):47. PMID: 27317311; PMCID: PMC4912796.
    6. Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 Jun; 18(6):632-44. PMID: 27183469; PMCID: PMC4884142 [Available on 12/01/16].
    7. Pfefferle AD, Agrawal YN, Koboldt DC, Kanchi KL, Herschkowitz JI, Mardis ER, Rosen JM, Perou CM. Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers. Dis Model Mech. 2016 Jul 1; 9(7):749-57. PMID: 27149990; PMCID: PMC4958311.
    8. Paine I, Chauviere A, Landua J, Sreekumar A, Cristini V, Rosen J, Lewis MT. A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud. PLoS Comput Biol. 2016 Apr; 12(4):e1004839. PMID: 27115287; PMCID: PMC4845990.
    9. Zhang M, Rosen JM. Developmental Insights into Breast Cancer Intratumoral Heterogeneity. Trends Cancer. 2015 Dec 01; 1(4):242-251. PMID: 26753176.
      View in: PubMed
    10. Holdman XB, Welte T, Rajapakshe K, Pond A, Coarfa C, Mo Q, Huang S, Hilsenbeck SG, Edwards DP, Zhang X, Rosen JM. Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer. Breast Cancer Res. 2015; 17:141. PMID: 26581390.
      View in: PubMed
    11. Shore AN, Chang CH, Kwon OJ, Weston MC, Zhang M, Xin L, Rosen JM. PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland. Dev Biol. 2016 Jan 1; 409(1):202-17. PMID: 26526198.
      View in: PubMed
    12. Chang CH, Zhang M, Rajapakshe K, Coarfa C, Edwards D, Huang S, Rosen JM. Mammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage. Stem Cell Reports. 2015 Sep 8; 5(3):378-91. PMID: 26300228.
      View in: PubMed
    13. Sreekumar A, Roarty K, Rosen JM. The mammary stem cell hierarchy: a looking glass into heterogeneous breast cancer landscapes. Endocr Relat Cancer. 2015 Dec; 22(6):T161-76. PMID: 26206777.
      View in: PubMed
    14. Silva GO, He X, Parker JS, Gatza ML, Carey LA, Hou JP, Moulder SL, Marcom PK, Ma J, Rosen JM, Perou CM. Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer. Breast Cancer Res Treat. 2015 Jul; 152(2):347-56. PMID: 26109346.
      View in: PubMed
    15. Knezevic J, Pfefferle AD, Petrovic I, Greene SB, Perou CM, Rosen JM. Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential. Oncogene. 2015 Dec 3; 34(49):5997-6006. PMID: 25746005; PMCID: PMC4564359.
    16. Zhang M, Tsimelzon A, Chang CH, Fan C, Wolff A, Perou CM, Hilsenbeck SG, Rosen JM. Intratumoral heterogeneity in a Trp53-null mouse model of human breast cancer. Cancer Discov. 2015 May; 5(5):520-33. PMID: 25735774; PMCID: PMC4420701.
    17. Roarty K, Shore AN, Creighton CJ, Rosen JM. Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium. J Cell Biol. 2015 Feb 2; 208(3):351-66. PMID: 25624393; PMCID: PMC4315251.
    18. Wang H, Yu C, Gao X, Welte T, Muscarella AM, Tian L, Zhao H, Zhao Z, Du S, Tao J, Lee B, Westbrook TF, Wong ST, Jin X, Rosen JM, Osborne CK, Zhang XH. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. Cancer Cell. 2015 Feb 9; 27(2):193-210. PMID: 25600338; PMCID: PMC4326554.
    19. Karlin KL, Mondal G, Hartman JK, Tyagi S, Kurley SJ, Bland CS, Hsu TY, Renwick A, Fang JE, Migliaccio I, Callaway C, Nair A, Dominguez-Vidana R, Nguyen DX, Osborne CK, Schiff R, Yu-Lee LY, Jung SY, Edwards DP, Hilsenbeck SG, Rosen JM, Zhang XH, Shaw CA, Couch FJ, Westbrook TF. The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor. Cell Rep. 2014 Nov 20; 9(4):1318-32. PMID: 25453754; PMCID: PMC4427000.
    20. Wei W, Tweardy DJ, Zhang M, Zhang X, Landua J, Petrovic I, Bu W, Roarty K, Hilsenbeck SG, Rosen JM, Lewis MT. STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer. Stem Cells. 2014 Oct; 32(10):2571-82. PMID: 24891218.
      View in: PubMed
    21. Vadakkan TJ, Landua JD, Bu W, Wei W, Li F, Wong ST, Dickinson ME, Rosen JM, Lewis MT, Zhang M. Wnt-responsive cancer stem cells are located close to distorted blood vessels and not in hypoxic regions in a p53-null mouse model of human breast cancer. Stem Cells Transl Med. 2014 Jul; 3(7):857-66. PMID: 24797826; PMCID: PMC4073819.
    22. Shore AN, Rosen JM. Regulation of mammary epithelial cell homeostasis by lncRNAs. Int J Biochem Cell Biol. 2014 Sep; 54:318-30. PMID: 24680897; PMCID: PMC4341896.
    23. Villegas E, Kabotyanski EB, Shore AN, Creighton CJ, Westbrook TF, Rosen JM. Plk2 regulates mitotic spindle orientation and mammary gland development. Development. 2014 Apr; 141(7):1562-71. PMID: 24598160; PMCID: PMC3957376.
    24. Rosen JM, Roarty K. Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity? Breast Cancer Res. 2014; 16(1):202. PMID: 24476463; PMCID: PMC3978850.
    25. Roarty K, Rosen JM. Pygopus 2: tilting the Wnt-Notch balance in mammary epithelial lineage determination. Breast Cancer Res. 2013; 15(6):322. PMID: 24365076; PMCID: PMC3979041.
    26. Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, Torres-Arzayus MI, Brown M, Egan SE, Wahl GM, Rosen JM, Perou CM. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 2013; 14(11):R125. PMID: 24220145; PMCID: PMC4053990.
    27. Zhu Y, Li F, Vadakkan TJ, Zhang M, Landua J, Wei W, Ma J, Dickinson ME, Rosen JM, Lewis MT, Zhan M, Wong ST. Three-dimensional vasculature reconstruction of tumour microenvironment via local clustering and classification. Interface Focus. 2013 Aug 6; 3(4):20130015. PMID: 24511379; PMCID: PMC3915834.
    28. Usary J, Zhao W, Darr D, Roberts PJ, Liu M, Balletta L, Karginova O, Jordan J, Combest A, Bridges A, Prat A, Cheang MC, Herschkowitz JI, Rosen JM, Zamboni W, Sharpless NE, Perou CM. Predicting drug responsiveness in human cancers using genetically engineered mice. Clin Cancer Res. 2013 Sep 1; 19(17):4889-99. PMID: 23780888; PMCID: PMC3778918.
    29. Machado HL, Kittrell FS, Edwards D, White AN, Atkinson RL, Rosen JM, Medina D, Lewis MT. Separation by cell size enriches for mammary stem cell repopulation activity. Stem Cells Transl Med. 2013 Mar; 2(3):199-203. PMID: 23408103; PMCID: PMC3659766.
    30. Hollier BG, Tinnirello AA, Werden SJ, Evans KW, Taube JH, Sarkar TR, Sphyris N, Shariati M, Kumar SV, Battula VL, Herschkowitz JI, Guerra R, Chang JT, Miura N, Rosen JM, Mani SA. FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer. Cancer Res. 2013 Mar 15; 73(6):1981-92. PMID: 23378344; PMCID: PMC3602160.
    31. Taube JH, Malouf GG, Lu E, Sphyris N, Vijay V, Ramachandran PP, Ueno KR, Gaur S, Nicoloso MS, Rossi S, Herschkowitz JI, Rosen JM, Issa JP, Calin GA, Chang JT, Mani SA. Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties. Sci Rep. 2013; 3:2687. PMID: 24045437; PMCID: PMC3776231.
    32. Pond AC, Bin X, Batts T, Roarty K, Hilsenbeck S, Rosen JM. Fibroblast growth factor receptor signaling is essential for normal mammary gland development and stem cell function. Stem Cells. 2013 Jan; 31(1):178-89. PMID: 23097355; PMCID: PMC3690809.
    33. Shore AN, Kabotyanski EB, Roarty K, Smith MA, Zhang Y, Creighton CJ, Dinger ME, Rosen JM. Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation. PLoS Genet. 2012; 8(7):e1002840. PMID: 22911650; PMCID: PMC3406180.
    34. Rosen JM. On murine mammary epithelial stem cells: discovery, function, and current status. Cold Spring Harb Perspect Biol. 2012 Apr; 4(4):a013268. PMID: 22474010; PMCID: PMC3312676.
    35. Shore AN, Herschkowitz JI, Rosen JM. Noncoding RNAs involved in mammary gland development and tumorigenesis: there's a long way to go. J Mammary Gland Biol Neoplasia. 2012 Mar; 17(1):43-58. PMID: 22402938; PMCID: PMC3637027.
    36. Behbod F, Rosen JM. Mammary gland development & breast cancer; connecting the dots by non-coding RNAs. J Mammary Gland Biol Neoplasia. 2012 Mar; 17(1):1-2. PMID: 22402939.
      View in: PubMed
    37. Rijnkels M, Kabotyanski E, Shore A, Rosen JM. The chromatin landscape of the casein gene locus. Horm Mol Biol Clin Investig. 2012 Mar 1; 10(1):201-205. PMID: 23914258.
      View in: PubMed
    38. Zhang L, Zhang B, Han SJ, Shore AN, Rosen JM, Demayo FJ, Xin L. Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis. Transgenic Res. 2012 Oct; 21(5):1117-23. PMID: 22350718; PMCID: PMC3433578.
    39. Rosen JM. On hormone action in the mammary gland. Cold Spring Harb Perspect Biol. 2012 Feb; 4(2). PMID: 22300979; PMCID: PMC3281567.
    40. Shahi P, Park D, Pond AC, Seethammagari M, Chiou SH, Cho K, Carstens JL, Decker WK, McCrea PD, Ittmann MM, Rosen JM, Spencer DM. Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis. PLoS One. 2012; 7(1):e30814. PMID: 22303459; PMCID: PMC3267738.
    41. Rainusso N, Brawley VS, Ghazi A, Hicks MJ, Gottschalk S, Rosen JM, Ahmed N. Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma. Cancer Gene Ther. 2012 Mar; 19(3):212-7. PMID: 22173710.
      View in: PubMed
    42. Batts TD, Machado HL, Zhang Y, Creighton CJ, Li Y, Rosen JM. Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration. PLoS One. 2011; 6(11):e27841. PMID: 22140470; PMCID: PMC3226565.
    43. Heckman-Stoddard BM, Vargo-Gogola T, Herrick MP, Visbal AP, Lewis MT, Settleman J, Rosen JM. P190A RhoGAP is required for mammary gland development. Dev Biol. 2011 Dec 1; 360(1):1-10. PMID: 21945077; PMCID: PMC3215776.
    44. Rainusso N, Man TK, Lau CC, Hicks J, Shen JJ, Yu A, Wang LL, Rosen JM. Identification and gene expression profiling of tumor-initiating cells isolated from human osteosarcoma cell lines in an orthotopic mouse model. Cancer Biol Ther. 2011 Aug 15; 12(4):278-87. PMID: 21617384; PMCID: PMC3173730.
    45. Herschkowitz JI, Zhao W, Zhang M, Usary J, Murrow G, Edwards D, Knezevic J, Greene SB, Darr D, Troester MA, Hilsenbeck SG, Medina D, Perou CM, Rosen JM. Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2778-83. PMID: 21633010; PMCID: PMC3286979.
    46. Buser AC, Obr AE, Kabotyanski EB, Grimm SL, Rosen JM, Edwards DP. Progesterone receptor directly inhibits ?-casein gene transcription in mammary epithelial cells through promoting promoter and enhancer repressive chromatin modifications. Mol Endocrinol. 2011 Jun; 25(6):955-68. PMID: 21527503; PMCID: PMC3386529.
    47. Kittrell FS, Carletti MZ, Kerbawy S, Heestand J, Xian W, Zhang M, Lamarca HL, Sonnenberg A, Rosen JM, Medina D, Behbod F. Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential. Breast Cancer Res. 2011; 13(2):R41. PMID: 21466693; PMCID: PMC3219204.
    48. Peddibhotla S, Wei Z, Papineni R, Lam MH, Rosen JM, Zhang P. The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression. Cell Cycle. 2011 Feb 15; 10(4):671-9. PMID: 21301228; PMCID: PMC3174002.
    49. Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ. The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A. 2011 Mar 1; 108(9):3665-70. PMID: 21307310; PMCID: PMC3048138.
    50. Visbal AP, LaMarca HL, Villanueva H, Toneff MJ, Li Y, Rosen JM, Lewis MT. Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened. Dev Biol. 2011 Apr 1; 352(1):116-27. PMID: 21276786; PMCID: PMC3057274.
    51. Wei Z, Peddibhotla S, Lin H, Fang X, Li M, Rosen JM, Zhang P. Early-onset aging and defective DNA damage response in Cdc14b-deficient mice. Mol Cell Biol. 2011 Apr; 31(7):1470-7. PMID: 21262768; PMCID: PMC3135283.
    52. Roarty K, Rosen JM. Wnt and mammary stem cells: hormones cannot fly wingless. Curr Opin Pharmacol. 2010 Dec; 10(6):643-9. PMID: 20810315; PMCID: PMC2981611.
    53. Atkinson RL, Zhang M, Diagaradjane P, Peddibhotla S, Contreras A, Hilsenbeck SG, Woodward WA, Krishnan S, Chang JC, Rosen JM. Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy. Sci Transl Med. 2010 Oct 27; 2(55):55ra79. PMID: 20980696; PMCID: PMC4123313.
    54. McHenry PR, Sears JC, Herrick MP, Chang P, Heckman-Stoddard BM, Rybarczyk M, Chodosh LA, Gunther EJ, Hilsenbeck SG, Rosen JM, Vargo-Gogola T. P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. Breast Cancer Res. 2010; 12(5):R73. PMID: 20860838.
      View in: PubMed
    55. Greene SB, Herschkowitz JI, Rosen JM. Small players with big roles: microRNAs as targets to inhibit breast cancer progression. Curr Drug Targets. 2010 Sep; 11(9):1059-73. PMID: 20545613; PMCID: PMC3006232.
    56. Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, Hollier BG, Ram PT, Lander ES, Rosen JM, Weinberg RA, Mani SA. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15449-54. PMID: 20713713; PMCID: PMC2932589.
    57. Dong J, Tong T, Reynado AM, Rosen JM, Huang S, Li Y. Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones. Dev Biol. 2010 Oct 15; 346(2):196-203. PMID: 20691178; PMCID: PMC3020144.
    58. Pond AC, Herschkowitz JI, Schwertfeger KL, Welm B, Zhang Y, York B, Cardiff RD, Hilsenbeck S, Perou CM, Creighton CJ, Lloyd RE, Rosen JM. Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer. Cancer Res. 2010 Jun 15; 70(12):4868-79. PMID: 20501844; PMCID: PMC3005245.
    59. Greene SB, Herschkowitz JI, Rosen JM. The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer. RNA Biol. 2010 May-Jun; 7(3):300-4. PMID: 20436283; PMCID: PMC3008649.
    60. Creighton CJ, Chang JC, Rosen JM. Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer. J Mammary Gland Biol Neoplasia. 2010 Jun; 15(2):253-60. PMID: 20354771.
      View in: PubMed
    61. LaMarca HL, Visbal AP, Creighton CJ, Liu H, Zhang Y, Behbod F, Rosen JM. CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland. Stem Cells. 2010 Mar 31; 28(3):535-44. PMID: 20054865; PMCID: PMC3006225.
    62. Rijnkels M, Kabotyanski E, Montazer-Torbati MB, Hue Beauvais C, Vassetzky Y, Rosen JM, Devinoy E. The epigenetic landscape of mammary gland development and functional differentiation. J Mammary Gland Biol Neoplasia. 2010 Mar; 15(1):85-100. PMID: 20157770; PMCID: PMC3006238.
    63. Zhang M, Atkinson RL, Rosen JM. Selective targeting of radiation-resistant tumor-initiating cells. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3522-7. PMID: 20133717; PMCID: PMC2840501.
    64. Reddy JP, Peddibhotla S, Bu W, Zhao J, Haricharan S, Du YC, Podsypanina K, Rosen JM, Donehower LA, Li Y. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3728-33. PMID: 20133707; PMCID: PMC2840493.
    65. Greene SB, Gunaratne PH, Hammond SM, Rosen JM. A putative role for microRNA-205 in mammary epithelial cell progenitors. J Cell Sci. 2010 Feb 15; 123(Pt 4):606-18. PMID: 20103531; PMCID: PMC2818197.
    66. Boles NC, Peddibhotla S, Chen AJ, Goodell MA, Rosen JM. Chk1 haploinsufficiency results in anemia and defective erythropoiesis. PLoS One. 2010; 5(1):e8581. PMID: 20052416; PMCID: PMC2798715.
    67. Heckman-Stoddard BM, Vargo-Gogola T, McHenry PR, Jiang V, Herrick MP, Hilsenbeck SG, Settleman J, Rosen JM. Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression. Breast Cancer Res. 2009; 11(4):R61. PMID: 19703301; PMCID: PMC2750123.
    68. Rosen JM, Woo SL, Comstock JP. Regulation of casein messenger RNA during the development of the rat mammary gland. 1975. J Mammary Gland Biol Neoplasia. 2009 Sep; 14(3):343-51. PMID: 19653075.
      View in: PubMed
    69. Peddibhotla S, Rosen JM. Chking and executing cell division to prevent genomic instability. Cell Cycle. 2009 Aug; 8(15):2339-42. PMID: 19571679.
      View in: PubMed
    70. Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, Sjolund A, Rimm DL, Wong H, Rodriguez A, Herschkowitz JI, Fan C, Zhang X, He X, Pavlick A, Gutierrez MC, Renshaw L, Larionov AA, Faratian D, Hilsenbeck SG, Perou CM, Lewis MT, Rosen JM, Chang JC. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):13820-5. PMID: 19666588; PMCID: PMC2720409.
    71. Rosen JM, Jordan CT. The increasing complexity of the cancer stem cell paradigm. Science. 2009 Jun 26; 324(5935):1670-3. PMID: 19556499; PMCID: PMC2873047.
    72. Kabotyanski EB, Rijnkels M, Freeman-Zadrowski C, Buser AC, Edwards DP, Rosen JM. Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elements. J Biol Chem. 2009 Aug 21; 284(34):22815-24. PMID: 19542223; PMCID: PMC2755689.
    73. Peddibhotla S, Lam MH, Gonzalez-Rimbau M, Rosen JM. The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5159-64. PMID: 19289837; PMCID: PMC2663996.
    74. Xian W, Pappas L, Pandya D, Selfors LM, Derksen PW, de Bruin M, Gray NS, Jonkers J, Rosen JM, Brugge JS. Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival. Cancer Res. 2009 Mar 15; 69(6):2244-51. PMID: 19258500.
      View in: PubMed
    75. Behbod F, Kittrell FS, LaMarca H, Edwards D, Kerbawy S, Heestand JC, Young E, Mukhopadhyay P, Yeh HW, Allred DC, Hu M, Polyak K, Rosen JM, Medina D. An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. Breast Cancer Res. 2009; 11(5):R66. PMID: 19735549; PMCID: PMC2790841.
    76. Zhang M, Behbod F, Atkinson RL, Landis MD, Kittrell F, Edwards D, Medina D, Tsimelzon A, Hilsenbeck S, Green JE, Michalowska AM, Rosen JM. Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res. 2008 Jun 15; 68(12):4674-82. PMID: 18559513; PMCID: PMC2459340.
    77. LaMarca HL, Rosen JM. Minireview: hormones and mammary cell fate--what will I become when I grow up? Endocrinology. 2008 Sep; 149(9):4317-21. PMID: 18556345; PMCID: PMC2553372.
    78. Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, Hilsenbeck SG, Pavlick A, Zhang X, Chamness GC, Wong H, Rosen J, Chang JC. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst. 2008 May 7; 100(9):672-9. PMID: 18445819.
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    79. Vargo-Gogola T, Rosen JM. Modelling breast cancer: one size does not fit all. Nat Rev Cancer. 2007 Sep; 7(9):659-72. PMID: 17721431.
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    80. Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM. Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev Biol. 2007 Sep 1; 309(1):137-49. PMID: 17662267; PMCID: PMC4011021.
    81. Mukhopadhyay SS, Rosen JM. The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells. Biochem Biophys Res Commun. 2007 Jul 6; 358(3):770-6. PMID: 17511965; PMCID: PMC1942171.
    82. Xian W, Schwertfeger KL, Rosen JM. Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition. Mol Endocrinol. 2007 Apr; 21(4):987-1000. PMID: 17284663.
      View in: PubMed
    83. Chen MS, Woodward WA, Behbod F, Peddibhotla S, Alfaro MP, Buchholz TA, Rosen JM. Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line. J Cell Sci. 2007 Feb 1; 120(Pt 3):468-77. PMID: 17227796.
      View in: PubMed
    84. Woodward WA, Chen MS, Behbod F, Alfaro MP, Buchholz TA, Rosen JM. WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci U S A. 2007 Jan 9; 104(2):618-23. PMID: 17202265; PMCID: PMC1766434.
    85. LaMarca HL, Rosen JM. Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage. Breast Cancer Res. 2007; 9(4):304. PMID: 17659070; PMCID: PMC2206713.
    86. Schwertfeger KL, Rosen JM, Cohen DA. Mammary gland macrophages: pleiotropic functions in mammary development. J Mammary Gland Biol Neoplasia. 2006 Oct; 11(3-4):229-38. PMID: 17115264.
      View in: PubMed
    87. Buser AC, Gass-Handel EK, Wyszomierski SL, Doppler W, Leonhardt SA, Schaack J, Rosen JM, Watkin H, Anderson SM, Edwards DP. Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells. Mol Endocrinol. 2007 Jan; 21(1):106-25. PMID: 16973758.
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    88. Grimm SL, Bu W, Longley MA, Roop DR, Li Y, Rosen JM. Keratin 6 is not essential for mammary gland development. Breast Cancer Res. 2006; 8(3):R29. PMID: 16790075; PMCID: PMC1557733.
    89. Kabotyanski EB, Huetter M, Xian W, Rijnkels M, Rosen JM. Integration of prolactin and glucocorticoid signaling at the beta-casein promoter and enhancer by ordered recruitment of specific transcription factors and chromatin modifiers. Mol Endocrinol. 2006 Oct; 20(10):2355-68. PMID: 16772529.
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    90. Schwertfeger KL, Xian W, Kaplan AM, Burnett SH, Cohen DA, Rosen JM. A critical role for the inflammatory response in a mouse model of preneoplastic progression. Cancer Res. 2006 Jun 1; 66(11):5676-85. PMID: 16740705.
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    91. Cella N, Contreras A, Latha K, Rosen JM, Zhang M. Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells. FASEB J. 2006 Jul; 20(9):1510-2. PMID: 16720730.
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    92. Ginger MR, Shore AN, Contreras A, Rijnkels M, Miller J, Gonzalez-Rimbau MF, Rosen JM. A noncoding RNA is a potential marker of cell fate during mammary gland development. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5781-6. PMID: 16574773; PMCID: PMC1420634.
    93. Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM. P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland. Mol Endocrinol. 2006 Jun; 20(6):1391-405. PMID: 16469769.
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    94. Grimm SL, Rosen JM. Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferating. Breast Cancer Res. 2006; 8(4):106. PMID: 16834786; PMCID: PMC1779470.
    95. Zhang M, Rosen JM. Stem cells in the etiology and treatment of cancer. Curr Opin Genet Dev. 2006 Feb; 16(1):60-4. PMID: 16377171.
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    96. Xian W, Schwertfeger KL, Vargo-Gogola T, Rosen JM. Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model. J Cell Biol. 2005 Nov 21; 171(4):663-73. PMID: 16301332; PMCID: PMC2171554.
    97. Behbod F, Xian W, Shaw CA, Hilsenbeck SG, Tsimelzon A, Rosen JM. Transcriptional profiling of mammary gland side population cells. Stem Cells. 2006 Apr; 24(4):1065-74. PMID: 16282442.
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    98. Grimm SL, Contreras A, Barcellos-Hoff MH, Rosen JM. Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null mice. J Biol Chem. 2005 Oct 28; 280(43):36301-9. PMID: 16120603.
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    99. Woodward WA, Chen MS, Behbod F, Rosen JM. On mammary stem cells. J Cell Sci. 2005 Aug 15; 118(Pt 16):3585-94. PMID: 16105882.
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    100. Li Y, Rosen JM. Stem/progenitor cells in mouse mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia. 2005 Jan; 10(1):17-24. PMID: 15886883.
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    101. Lam MH, Rosen JM. Chk1 versus Cdc25: chking one's levels of cellular proliferation. Cell Cycle. 2004 Nov; 3(11):1355-7. PMID: 15483403.
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    102. Behbod F, Rosen JM. Will cancer stem cells provide new therapeutic targets? Carcinogenesis. 2005 Apr; 26(4):703-11. PMID: 15459022.
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    103. Lam MH, Liu Q, Elledge SJ, Rosen JM. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell. 2004 Jul; 6(1):45-59. PMID: 15261141.
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    104. Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HE. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15853-8. PMID: 14668450; PMCID: PMC307657.
    105. Contreras A, Hale TK, Stenoien DL, Rosen JM, Mancini MA, Herrera RE. The dynamic mobility of histone H1 is regulated by cyclin/CDK phosphorylation. Mol Cell Biol. 2003 Dec; 23(23):8626-36. PMID: 14612406; PMCID: PMC262667.
    106. Freeman KW, Welm BE, Gangula RD, Rosen JM, Ittmann M, Greenberg NM, Spencer DM. Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice. Cancer Res. 2003 Dec 1; 63(23):8256-63. PMID: 14678983.
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    107. Hernandez I, Maddison LA, Wei Y, DeMayo F, Petras T, Li B, Gingrich JR, Rosen JM, Greenberg NM. Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival. Mol Cancer Res. 2003 Dec; 1(14):1036-47. PMID: 14707287.
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    108. Welm B, Behbod F, Goodell MA, Rosen JM. Isolation and characterization of functional mammary gland stem cells. Cell Prolif. 2003 Oct; 36 Suppl 1:17-32. PMID: 14521513; PMCID: PMC3496772.
    109. Rijnkels M, Elnitski L, Miller W, Rosen JM. Multispecies comparative analysis of a mammalian-specific genomic domain encoding secretory proteins. Genomics. 2003 Oct; 82(4):417-32. PMID: 13679022.
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    110. Freeman KW, Gangula RD, Welm BE, Ozen M, Foster BA, Rosen JM, Ittmann M, Greenberg NM, Spencer DM. Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation. Cancer Res. 2003 Oct 1; 63(19):6237-43. PMID: 14559809.
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    111. Rosen JM. Striking it rich by data mining. Cell. 2003 Aug 8; 114(3):271-2. PMID: 12914689.
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    112. Lee AV, Zhang P, Ivanova M, Bonnette S, Oesterreich S, Rosen JM, Grimm S, Hovey RC, Vonderhaar BK, Kahn CR, Torres D, George J, Mohsin S, Allred DC, Hadsell DL. Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland. Endocrinology. 2003 Jun; 144(6):2683-94. PMID: 12746333.
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    113. Ginger MR, Rosen JM. Pregnancy-induced changes in cell-fate in the mammary gland. Breast Cancer Res. 2003; 5(4):192-7. PMID: 12817990; PMCID: PMC165015.
    114. Grimm SL, Rosen JM. The role of C/EBPbeta in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia. 2003 Apr; 8(2):191-204. PMID: 14635794.
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    115. Rosen JM. Transcription factors. J Mammary Gland Biol Neoplasia. 2003 Apr; 8(2):143-4. PMID: 14635790.
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    116. Pownall ME, Welm BE, Freeman KW, Spencer DM, Rosen JM, Isaacs HV. An inducible system for the study of FGF signalling in early amphibian development. Dev Biol. 2003 Apr 1; 256(1):89-99. PMID: 12654294.
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    117. Tepera SB, McCrea PD, Rosen JM. A beta-catenin survival signal is required for normal lobular development in the mammary gland. J Cell Sci. 2003 Mar 15; 116(Pt 6):1137-49. PMID: 12584256.
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    118. Chakravarty G, Hadsell D, Buitrago W, Settleman J, Rosen JM. p190-B RhoGAP regulates mammary ductal morphogenesis. Mol Endocrinol. 2003 Jun; 17(6):1054-65. PMID: 12637587.
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    119. Kabotyanski EB, Rosen JM. Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b. J Biol Chem. 2003 May 9; 278(19):17218-27. PMID: 12621061.
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    120. Medina D, Kittrell FS, Shepard A, Contreras A, Rosen JM, Lydon J. Hormone dependence in premalignant mammary progression. Cancer Res. 2003 Mar 1; 63(5):1067-72. PMID: 12615724.
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    121. Rosen JM. Hormone receptor patterning plays a critical role in normal lobuloalveolar development and breast cancer progression. Breast Dis. 2003; 18:3-9. PMID: 15687684.
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    122. Grimm SL, Seagroves TN, Kabotyanski EB, Hovey RC, Vonderhaar BK, Lydon JP, Miyoshi K, Hennighausen L, Ormandy CJ, Lee AV, Stull MA, Wood TL, Rosen JM. Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development. Mol Endocrinol. 2002 Dec; 16(12):2675-91. PMID: 12456789.
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    123. Kingsley-Kallesen M, Mukhopadhyay SS, Wyszomierski SL, Schanler S, Schütz G, Rosen JM. The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development. Mol Endocrinol. 2002 Sep; 16(9):2008-18. PMID: 12198239.
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    124. Welm BE, Freeman KW, Chen M, Contreras A, Spencer DM, Rosen JM. Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland. J Cell Biol. 2002 May 13; 157(4):703-14. PMID: 12011115; PMCID: PMC2173854.
    125. Welm BE, Tepera SB, Venezia T, Graubert TA, Rosen JM, Goodell MA. Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. Dev Biol. 2002 May 1; 245(1):42-56. PMID: 11969254.
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    126. Shillingford JM, Miyoshi K, Robinson GW, Grimm SL, Rosen JM, Neubauer H, Pfeffer K, Hennighausen L. Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium. Mol Endocrinol. 2002 Mar; 16(3):563-70. PMID: 11875116.
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    127. Medina D, Sivaraman L, Hilsenbeck SG, Conneely O, Ginger M, Rosen J, Omalle BW. Mechanisms of hormonal prevention of breast cancer. Ann N Y Acad Sci. 2001 Dec; 952:23-35. PMID: 11795441.
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    128. Miyoshi K, Shillingford JM, Smith GH, Grimm SL, Wagner KU, Oka T, Rosen JM, Robinson GW, Hennighausen L. Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol. 2001 Nov 12; 155(4):531-42. PMID: 11706048; PMCID: PMC2198867.
    129. Ginger MR, Gonzalez-Rimbau MF, Gay JP, Rosen JM. Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland. Mol Endocrinol. 2001 Nov; 15(11):1993-2009. PMID: 11682629.
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    130. Mukhopadhyay SS, Wyszomierski SL, Gronostajski RM, Rosen JM. Differential interactions of specific nuclear factor I isoforms with the glucocorticoid receptor and STAT5 in the cooperative regulation of WAP gene transcription. Mol Cell Biol. 2001 Oct; 21(20):6859-69. PMID: 11564870; PMCID: PMC99863.
    131. Rijnkels M, Rosen JM. Adenovirus-Cre-mediated recombination in mammary epithelial early progenitor cells. J Cell Sci. 2001 Sep; 114(Pt 17):3147-53. PMID: 11590241.
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    132. Wyszomierski SL, Rosen JM. Cooperative effects of STAT5 (signal transducer and activator of transcription 5) and C/EBPbeta (CCAAT/enhancer-binding protein-beta) on beta-casein gene transcription are mediated by the glucocorticoid receptor. Mol Endocrinol. 2001 Feb; 15(2):228-40. PMID: 11158330.
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    133. Zahnow CA, Cardiff RD, Laucirica R, Medina D, Rosen JM. A role for CCAAT/enhancer binding protein beta-liver-enriched inhibitory protein in mammary epithelial cell proliferation. Cancer Res. 2001 Jan 1; 61(1):261-9. PMID: 11196172.
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    134. Kazansky AV, Rosen JM. Signal transducers and activators of transcription 5B potentiates v-Src-mediated transformation of NIH-3T3 cells. Cell Growth Differ. 2001 Jan; 12(1):1-7. PMID: 11205741.
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    135. Murphy KL, Dennis AP, Rosen JM. A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model. FASEB J. 2000 Nov; 14(14):2291-302. PMID: 11053251.
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    136. Chakravarty G, Roy D, Gonzales M, Gay J, Contreras A, Rosen JM. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. Cell Growth Differ. 2000 Jul; 11(7):343-54. PMID: 10939588.
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    137. Seagroves TN, Lydon JP, Hovey RC, Vonderhaar BK, Rosen JM. C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development. Mol Endocrinol. 2000 Mar; 14(3):359-68. PMID: 10707954.
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    138. Murphy KL, Rosen JM. Mutant p53 and genomic instability in a transgenic mouse model of breast cancer. Oncogene. 2000 Feb 21; 19(8):1045-51. PMID: 10713688.
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    139. Hadsell DL, Murphy KL, Bonnette SG, Reece N, Laucirica R, Rosen JM. Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis. Oncogene. 2000 Feb 17; 19(7):889-98. PMID: 10702797.
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    140. Murphy KL, Kittrell FS, Gay JP, Jäger R, Medina D, Rosen JM. Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice. Oncogene. 1999 Nov 11; 18(47):6597-604. PMID: 10597264.
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    141. Kazansky AV, Kabotyanski EB, Wyszomierski SL, Mancini MA, Rosen JM. Differential effects of prolactin and src/abl kinases on the nuclear translocation of STAT5B and STAT5A. J Biol Chem. 1999 Aug 6; 274(32):22484-92. PMID: 10428824.
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    142. Wyszomierski SL, Yeh J, Rosen JM. Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation. Mol Endocrinol. 1999 Feb; 13(2):330-43. PMID: 9973262.
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    143. Rosen JM, Wyszomierski SL, Hadsell D. Regulation of milk protein gene expression. Annu Rev Nutr. 1999; 19:407-36. PMID: 10448531.
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    144. Seagroves TN, Krnacik S, Raught B, Gay J, Burgess-Beusse B, Darlington GJ, Rosen JM. C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes Dev. 1998 Jun 15; 12(12):1917-28. PMID: 9637692; PMCID: PMC316914.
    145. Li B, Murphy KL, Laucirica R, Kittrell F, Medina D, Rosen JM. A transgenic mouse model for mammary carcinogenesis. Oncogene. 1998 Feb 26; 16(8):997-1007. PMID: 9519874.
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    146. Rosen JM, Zahnow C, Kazansky A, Raught B. Composite response elements mediate hormonal and developmental regulation of milk protein gene expression. Biochem Soc Symp. 1998; 63:101-13. PMID: 9513715.
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    147. Zahnow CA, Younes P, Laucirica R, Rosen JM. Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer. J Natl Cancer Inst. 1997 Dec 17; 89(24):1887-91. PMID: 9414177.
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    148. Humphreys RC, Lydon JP, O'Malley BW, Rosen JM. Use of PRKO mice to study the role of progesterone in mammary gland development. J Mammary Gland Biol Neoplasia. 1997 Oct; 2(4):343-54. PMID: 10935022.
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    149. Humphreys RC, Rosen JM. Stably transfected HC11 cells provide an in vitro and in vivo model system for studying Wnt gene function. Cell Growth Differ. 1997 Aug; 8(8):839-49. PMID: 9269893.
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    150. Li B, Rosen JM, McMenamin-Balano J, Muller WJ, Perkins AS. neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice. Mol Cell Biol. 1997 Jun; 17(6):3155-63. PMID: 9154814; PMCID: PMC232168.
    151. Humphreys RC, Lydon J, O'Malley BW, Rosen JM. Mammary gland development is mediated by both stromal and epithelial progesterone receptors. Mol Endocrinol. 1997 Jun; 11(6):801-11. PMID: 9171243.
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    152. Yarus S, Weaver TE, Rosen JM. The carboxy-terminal domain of human surfactant protein B is not required for secretion in milk of transgenic mice. Front Biosci. 1997 May 1; 2:a1-8. PMID: 9206990.
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    153. Yarus S, Greenberg NM, Wei Y, Whitsett JA, Weaver TE, Rosen JM. Secretion of unprocessed human surfactant protein B in milk of transgenic mice. Transgenic Res. 1997 Jan; 6(1):51-7. PMID: 9032978.
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    154. Humphreys RC, Krajewska M, Krnacik S, Jaeger R, Weiher H, Krajewski S, Reed JC, Rosen JM. Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. Development. 1996 Dec; 122(12):4013-22. PMID: 9012521.
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    155. Yarus S, Rosen JM, Cole AM, Diamond G. Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14118-21. PMID: 8943070; PMCID: PMC19503.
    156. Raught B, Gingras AC, James A, Medina D, Sonenberg N, Rosen JM. Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells. Cancer Res. 1996 Oct 1; 56(19):4382-6. PMID: 8813130.
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    157. Gingrich JR, Barrios RJ, Morton RA, Boyce BF, DeMayo FJ, Finegold MJ, Angelopoulou R, Rosen JM, Greenberg NM. Metastatic prostate cancer in a transgenic mouse. Cancer Res. 1996 Sep 15; 56(18):4096-102. PMID: 8797572.
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    158. Rosen JM, Li S, Raught B, Hadsell D. The mammary gland as a bioreactor: factors regulating the efficient expression of milk protein-based transgenes. Am J Clin Nutr. 1996 Apr; 63(4):627S-32S. PMID: 8599330.
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    159. Yarus S, Hadsell D, Rosen JM. Engineering transgenes for use in the mammary gland. Genet Eng (N Y). 1996; 18:57-81. PMID: 8785127.
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    160. Hadsell DL, Greenberg NM, Fligger JM, Baumrucker CR, Rosen JM. Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression. Endocrinology. 1996 Jan; 137(1):321-30. PMID: 8536631.
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    161. Kazansky AV, Raught B, Lindsey SM, Wang YF, Rosen JM. Regulation of mammary gland factor/Stat5a during mammary gland development. Mol Endocrinol. 1995 Nov; 9(11):1598-609. PMID: 8584036.
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    162. Li B, Kittrell FS, Medina D, Rosen JM. Delay of dimethylbenz[a]anthracene-induced mammary tumorigenesis in transgenic mice by apoptosis induced by an unusual mutant p53 protein. Mol Carcinog. 1995 Oct; 14(2):75-83. PMID: 7576102.
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    163. Raught B, Liao WS, Rosen JM. Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence beta-casein gene expression. Mol Endocrinol. 1995 Sep; 9(9):1223-32. PMID: 7491114.
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    164. Wei Y, Yarus S, Greenberg NM, Whitsett J, Rosen JM. Production of human surfactant protein C in milk of transgenic mice. Transgenic Res. 1995 Jul; 4(4):232-40. PMID: 7655513.
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    165. Krnacik MJ, Li S, Liao J, Rosen JM. Position-independent expression of whey acidic protein transgenes. J Biol Chem. 1995 May 12; 270(19):11119-29. PMID: 7744742.
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    166. Greenberg NM, DeMayo F, Finegold MJ, Medina D, Tilley WD, Aspinall JO, Cunha GR, Donjacour AA, Matusik RJ, Rosen JM. Prostate cancer in a transgenic mouse. Proc Natl Acad Sci U S A. 1995 Apr 11; 92(8):3439-43. PMID: 7724580; PMCID: PMC42182.
    167. Li S, Rosen JM. Nuclear factor I and mammary gland factor (STAT5) play a critical role in regulating rat whey acidic protein gene expression in transgenic mice. Mol Cell Biol. 1995 Apr; 15(4):2063-70. PMID: 7891701; PMCID: PMC230433.
    168. Li S, Rosen JM. Glucocorticoid regulation of rat whey acidic protein gene expression involves hormone-induced alterations of chromatin structure in the distal promoter region. Mol Endocrinol. 1994 Oct; 8(10):1328-35. PMID: 7854350.
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    169. Li B, Greenberg N, Stephens LC, Meyn R, Medina D, Rosen JM. Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development. Cell Growth Differ. 1994 Jul; 5(7):711-21. PMID: 7947386.
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    170. Li S, Rosen JM. Distal regulatory elements required for rat whey acidic protein gene expression in transgenic mice. J Biol Chem. 1994 May 13; 269(19):14235-43. PMID: 8188706.
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    171. Raught B, Khursheed B, Kazansky A, Rosen J. YY1 represses beta-casein gene expression by preventing the formation of a lactation-associated complex. Mol Cell Biol. 1994 Mar; 14(3):1752-63. PMID: 8114709; PMCID: PMC358533.
    172. Coleman-Krnacik S, Rosen JM. Differential temporal and spatial gene expression of fibroblast growth factor family members during mouse mammary gland development. Mol Endocrinol. 1994 Feb; 8(2):218-29. PMID: 8170478.
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    173. Greenberg NM, DeMayo FJ, Sheppard PC, Barrios R, Lebovitz R, Finegold M, Angelopoulou R, Dodd JG, Duckworth ML, Rosen JM, et al. The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice. Mol Endocrinol. 1994 Feb; 8(2):230-9. PMID: 8170479.
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    174. Rosen JM, Humphreys R, Krnacik S, Juo P, Raught B. The regulation of mammary gland development by hormones, growth factors, and oncogenes. Prog Clin Biol Res. 1994; 387:95-111. PMID: 7972261.
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    175. Bühler TA, Dale TC, Kieback C, Humphreys RC, Rosen JM. Localization and quantification of Wnt-2 gene expression in mouse mammary development. Dev Biol. 1993 Jan; 155(1):87-96. PMID: 8416847.
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    176. Wolff J, Wong C, Cheng H, Poyet P, Butel JS, Rosen JM. Differential effects of the simian virus 40 early genes on mammary epithelial cell growth, morphology, and gene expression. Exp Cell Res. 1992 Sep; 202(1):67-76. PMID: 1324845.
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    177. Dale TC, Krnacik MJ, Schmidhauser C, Yang CL, Bissell MJ, Rosen JM. High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region. Mol Cell Biol. 1992 Mar; 12(3):905-14. PMID: 1545822; PMCID: PMC369522.
    178. Greenberg NM, Wolfe J, Rosen JM. Casein gene expression: from transfection to transgenics. Cancer Treat Res. 1992; 61:379-97. PMID: 1360241.
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    179. Greenberg NM, Anderson JW, Hsueh AJ, Nishimori K, Reeves JJ, deAvila DM, Ward DN, Rosen JM. Expression of biologically active heterodimeric bovine follicle-stimulating hormone in milk of transgenic mice. Proc Natl Acad Sci U S A. 1991 Oct 1; 88(19):8327-31. PMID: 1924292; PMCID: PMC52501.
    180. Greenberg NM, Reding TV, Duffy T, Rosen JM. A heterologous hormone response element enhances expression of rat beta-casein promoter-driven chloramphenicol acetyltransferase fusion genes in the mammary gland of transgenic mice. Mol Endocrinol. 1991 Oct; 5(10):1504-12. PMID: 1775134.
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    181. Goodman HS, Rosen JM. Transcriptional analysis of the mouse beta-casein gene. Mol Endocrinol. 1990 Nov; 4(11):1661-70. PMID: 2280771.
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    182. Bayna EM, Rosen JM. Tissue-specific, high level expression of the rat whey acidic protein gene in transgenic mice. Nucleic Acids Res. 1990 May 25; 18(10):2977-85. PMID: 2349094; PMCID: PMC330827.
    183. Rosen JM, Bayna E, Lee KF. Analysis of milk protein gene expression in transgenic mice. Mol Biol Med. 1989 Dec; 6(6):501-9. PMID: 2699509.
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    184. Poyet P, Henning SJ, Rosen JM. Hormone-dependent beta-casein mRNA stabilization requires ongoing protein synthesis. Mol Endocrinol. 1989 Dec; 3(12):1961-8. PMID: 2628732.
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    185. Dale TC, Rosen JM, Guille MJ, Lewin AR, Porter AG, Kerr IM, Stark GR. Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription. EMBO J. 1989 Mar; 8(3):831-9. PMID: 2721502; PMCID: PMC400881.
    186. Lee KF, Atiee SH, Henning SJ, Rosen JM. Relative contribution of promoter and intragenic sequences in the hormonal regulation of rat beta-casein transgenes. Mol Endocrinol. 1989 Mar; 3(3):447-53. PMID: 2747652.
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    187. Lee KF, Atiee SH, Rosen JM. Differential regulation of rat beta-casein-chloramphenicol acetyltransferase fusion gene expression in transgenic mice. Mol Cell Biol. 1989 Feb; 9(2):560-5. PMID: 2710117; PMCID: PMC362632.
    188. Rosen JM, Poyet P, Goodman H, Lee KF. Mechanisms by which prolactin and glucocorticoids regulate casein gene expression. Biochem Soc Symp. 1989; 55:115-23. PMID: 2619762.
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    189. Eisenstein RS, Rosen JM. Both cell substratum regulation and hormonal regulation of milk protein gene expression are exerted primarily at the posttranscriptional level. Mol Cell Biol. 1988 Aug; 8(8):3183-90. PMID: 3062379; PMCID: PMC363548.
    190. Campbell SM, Taha MM, Medina D, Rosen JM. A clonal derivative of mammary epithelial cell line COMMA-D retains stem cell characteristics of unique morphological and functional heterogeneity. Exp Cell Res. 1988 Jul; 177(1):109-21. PMID: 2455648.
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    191. Yu-Lee LY, Rosen JM. A transfected alpha-casein minigene bypasses posttranscriptional control by hormones, but retains cell-substratum regulation in mammary epithelial cells. Mol Endocrinol. 1988 May; 2(5):431-43. PMID: 2458523.
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    192. Lee KF, DeMayo FJ, Atiee SH, Rosen JM. Tissue-specific expression of the rat beta-casein gene in transgenic mice. Nucleic Acids Res. 1988 Feb 11; 16(3):1027-41. PMID: 3344200; PMCID: PMC334735.
    193. Brown TL, Rosen JM. Isolation and characterization of milk protein nuclear RNAs in rat mammary gland. Anal Biochem. 1986 Mar; 153(2):211-20. PMID: 2871772.
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    194. Yu-Lee LY, Richter-Mann L, Couch CH, Stewart AF, Mackinlay AG, Rosen JM. Evolution of the casein multigene family: conserved sequences in the 5' flanking and exon regions. Nucleic Acids Res. 1986 Feb 25; 14(4):1883-902. PMID: 3952000; PMCID: PMC339580.
    195. Rosen JM, Rodgers JR, Couch CH, Bisbee CA, David-Inouye Y, Campbell SM, Yu-Lee LY. Multihormonal regulation of milk protein gene expression. Ann N Y Acad Sci. 1986; 478:63-76. PMID: 3541754.
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    196. Rosen JM, Jones WK, Rodgers JR, Compton JG, Bisbee CA, David-Inouye Y, Yu-Lee LY. Regulatory sequences involved in the hormonal control of casein gene expression. Ann N Y Acad Sci. 1986; 464:87-99. PMID: 3014951.
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    197. Johnson ML, Levy J, Rosen JM. Maintenance of milk protein gene expression in a subpopulation of 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinoma cells grown on attached collagen gels. In Vitro Cell Dev Biol. 1985 Aug; 21(8):439-44. PMID: 3928590.
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    198. Jones WK, Yu-Lee LY, Clift SM, Brown TL, Rosen JM. The rat casein multigene family. Fine structure and evolution of the beta-casein gene. J Biol Chem. 1985 Jun 10; 260(11):7042-50. PMID: 3997858.
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    199. Rodgers JR, Johnson ML, Rosen JM. Measurement of mRNA concentration and mRNA half-life as a function of hormonal treatment. Methods Enzymol. 1985; 109:572-92. PMID: 3838791.
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    200. Campbell SM, Rosen JM, Hennighausen LG, Strech-Jurk U, Sippel AE. Comparison of the whey acidic protein genes of the rat and mouse. Nucleic Acids Res. 1984 Nov 26; 12(22):8685-97. PMID: 6095207; PMCID: PMC320407.
    201. Johnson ML, Levy J, Supowit SC, Yu-Lee LY, Rosen JM. Tissue- and cell-specific casein gene expression. II. Relationship to site-specific DNA methylation. J Biol Chem. 1983 Sep 10; 258(17):10805-11. PMID: 6411721.
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    202. Yu-Lee LY, Rosen JM. The rat casein multigene family. I. Fine structure of the gamma-casein gene. J Biol Chem. 1983 Sep 10; 258(17):10794-804. PMID: 6309815.
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    203. Johnson ML, Levy J, Rosen JM. Isolation and characterization of casein-producing and -nonproducing cell populations from 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinomas. Cancer Res. 1983 May; 43(5):2199-209. PMID: 6187446.
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    204. Hobbs AA, Rosen JM. Sequence of rat alpha- and gamma-casein mRNAs: evolutionary comparison of the calcium-dependent rat casein multigene family. Nucleic Acids Res. 1982 Dec 20; 10(24):8079-98. PMID: 6298707; PMCID: PMC327071.
    205. Hennighausen LG, Sippel AE, Hobbs AA, Rosen JM. Comparative sequence analysis of the mRNAs coding for mouse and rat whey protein. Nucleic Acids Res. 1982 Jun 25; 10(12):3733-44. PMID: 6896749; PMCID: PMC320747.
    206. Blackburn DE, Hobbs AA, Rosen JM. Rat beta casein cDNA: sequence analysis and evolutionary comparisons. Nucleic Acids Res. 1982 Apr 10; 10(7):2295-307. PMID: 6283475; PMCID: PMC320610.
    207. Hobbs AA, Richards DA, Kessler DJ, Rosen JM. Complex hormonal regulation of rat casein gene expression. J Biol Chem. 1982 Apr 10; 257(7):3598-605. PMID: 6895895.
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    208. Supowit SC, Rosen JM. Hormonal induction of casein gene expression limited to a small subpopulation of 7,12-dimethylbenz(a)anthracene-induced mammary tumor cells. Cancer Res. 1982 Apr; 42(4):1355-60. PMID: 6800652.
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    209. Gupta P, Rosen JM, D'Eustachio P, Ruddle FH. Localization of the casein gene family to a single mouse chromosome. J Cell Biol. 1982 Apr; 93(1):199-204. PMID: 6896059; PMCID: PMC2112097.
    210. Supowit SC, Rosen JM. Tumor-specific polyadenylated RNA's from 7,12-dimethylbenz(a)anthracene-induced mammary tumors revealed through hybridization with fractionated single-copy DNA. Cancer Res. 1981 Oct; 41(10):3827-34. PMID: 6169428.
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    211. Richards DA, Rodgers JR, Supowit SC, Rosen JM. Construction and preliminary characterization of the rat casein and alpha-lactalbumin cDNA clones. J Biol Chem. 1981 Jan 10; 256(1):526-32. PMID: 7005218.
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    212. Richards DA, Blackburn DE, Rosen JM. Restriction enzyme mapping and heteroduplex analysis of the rat milk protein cDNA clones. J Biol Chem. 1981 Jan 10; 256(1):533-8. PMID: 6256356.
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    213. Supowit SC, Rosen JM. Gene expression in normal and neoplastic mammary tissue. Biochemistry. 1980 Jul 22; 19(15):3452-60. PMID: 6157399.
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    214. Warner MR, Yau L, Rosen JM. Long term effects of perinatal injection of estrogen and progesterone on the morphological and biochemical development of the mammary gland. Endocrinology. 1980 Mar; 106(3):823-32. PMID: 7353545.
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    215. Rosen JM, Matusik RJ, Richards DA, Gupta P, Rodgers JR. Multihormonal regulation of casein gene expression at the transcriptional and posttransciptional levels in the mammary gland. Recent Prog Horm Res. 1980; 36:157-93. PMID: 6997941.
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    216. Matusik RJ, Rosen JM. Prolactin regulation of casein gene expression: possible mediators. Endocrinology. 1980 Jan; 106(1):252-9. PMID: 6243098.
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    217. Guyette WA, Matusik RJ, Rosen JM. Prolactin-mediated transcriptional and post-transcriptional control of casein gene expression. Cell. 1979 Aug; 17(4):1013-23. PMID: 487427.
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    218. Dudley JP, Butel JS, Socher SH, Rosen JM. Detection of mouse mammary tumor virus RNA in BALB/c tumor cell lines of nonviral etiologies. J Virol. 1978 Dec; 28(3):743-52. PMID: 215778; PMCID: PMC525798.
    219. Dudley JP, Rosen JM, Butel JS. Differential expression of poly(A)-adjacent sequences of mammary tumor virus RNA in murine mammary cells. Proc Natl Acad Sci U S A. 1978 Dec; 75(12):5797-801. PMID: 83648; PMCID: PMC393062.
    220. Vonderhaar BK, Smith GH, Pauley RJ, Rosen JM, Topper YJ. Difference between mammary epithelial cells from mature virgin and primiparous mice. Cancer Res. 1978 Nov; 38(11 Pt 2):4059-65. PMID: 100213.
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    221. Pauley RJ, Rosen JM, Socher SH. Mammary tumour virus and casein gene transcription during mouse mammary development. Nature. 1978 Oct 5; 275(5679):455-7. PMID: 211437.
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    222. Matusik RJ, Rosen JM. Prolactin induction of casein mRNA in organ culture. A model system for studying peptide hormone regulation of gene expression. J Biol Chem. 1978 Apr 10; 253(7):2343-7. PMID: 632273.
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    223. Rosen JM, O'Neal DL, McHugh JE, Comstock JP. Progesterone-mediated inhibition of casein mRNA and polysomal casein synthesis in the rat mammary gland during pregnancy. Biochemistry. 1978 Jan 24; 17(2):290-7. PMID: 619992.
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    224. Rosen JM, Socher SH. Detection of casein messenger RNA in hormone-dependent mammary cancer by molecular hybridisation. Nature. 1977 Sep 1; 269(5623):83-6. PMID: 408713.
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    225. Chan L, Harris SE, Rosen JM, Means AR, O'Malley BW. Processing of nuclear heterogeneous RNA: recent developments. Life Sci. 1977 Jan 1; 20(1):1-15. PMID: 319316.
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    226. Rosen JM. Isolation and characterization of purified rat casein messenger ribonucleic acids. Biochemistry. 1976 Nov 30; 15(24):5263-71. PMID: 999806.
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    227. Rosen JM, Barker SW. Quantitation of casein messenger ribonucleic acid sequences using a specific complementary DNA hybridization probe. Biochemistry. 1976 Nov 30; 15(24):5272-80. PMID: 63286.
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    228. Woo SL, Rosen JM, Liarakos CD, Choi YC, Busch H, Means AR. Physical and chemical characterization of purified ovalbumin messenger RNA. J Biol Chem. 1975 Sep 10; 250(17):7027-39. PMID: 1158896.
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    229. Rosen JM, Chan L, Woo SL, Harris SE, Means AR, O'Malley BW. Effect of estrogen on the synthesis and processing of ovalbumin messenger RNA in the chick oviduct. Brookhaven Symp Biol. 1975 Jul; (26):320-32. PMID: 1192242.
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    230. Rosen JM, Woo SL, Comstock JP. Regulation of casein messenger RNA during the development of the rat mammary gland. Biochemistry. 1975 Jul; 14(13):2895-903. PMID: 1148182.
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    231. Harris SE, Rosen JM, Means AR, O'Malley BW. Use of a specific probe for ovalbumin messenger RNA to quantitate estrogen-induced gene transcripts. Biochemistry. 1975 May 20; 14(10):2072-81. PMID: 50081.
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    232. Rosen JM, Woo SL, Holder JW, Means AR, O'Malley BW. Preparation and preliminary characterization of purified ovalbumin messenger RNA from the hen oviduct. Biochemistry. 1975 Jan 14; 14(1):69-78. PMID: 1109593.
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    233. Rosen JM, Harris SE, Rosenfeld GC, Liarakos CD, O'Malley BW. Effect of estrogen on gene expression in the chick oviduct. 3. Hybridization studies with (3H) messenger RNA and (3H) complementary DNA under conditions of DNA excess. Cell Differ. 1974 Jul; 3(2):103-16. PMID: 4136693.
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    234. Woo SL, Harris SE, Rosen JM, Chan L, Sperry PJ, Means AR, O'Malley BW. Use of Sepharose 4B for preparative scale fractionation of eukaryotic messenger RNA's. Prep Biochem. 1974; 4(6):555-72. PMID: 4475423.
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    235. Rosen JM, Liarakos CD, O'Malley BW. Effect of estrogen on gene expression in the chick oviduct. I. Deoxyribonucleic acid--deoxyribonucleic acid renaturation studies. Biochemistry. 1973 Jul 17; 12(15):2803-9. PMID: 4719119.
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    236. Liarakos CD, Rosen JM, O'Malley BW. Effect of estrogen on gene expression in the chick oviduct. II. Transcription of chick tritiated unique deoxyribonucleic acid as measured by hybridization in ribonucleic acid excess. Biochemistry. 1973 Jul 17; 12(15):2809-16. PMID: 4719120.
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    237. Wang JJ, Chervinsky DS, Rosen JM. Comparative biochemical studies of adriamycin and daunomycin in leukemic cells. Cancer Res. 1972 Mar; 32(3):511-5. PMID: 5061305.
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    238. Rosen JM, Fina JJ, Milholland RJ, Rosen F. Inhibitory effect of cortisol in vitro on 2-deoxyglucose uptake and RNA and protein metabolism in lymphosarcoma P1798. Cancer Res. 1972 Feb; 32(2):350-5. PMID: 5066716.
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    239. Rosen JM, Milholland RJ, Rosen F. A comparison of the effect of glucocorticoids on glucose uptake and hexokinase activity in lymphosarcoma P1798. Biochim Biophys Acta. 1970 Dec 1; 219(2):447-54. PMID: 5537126.
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    240. Rosen JM, Fina JR, Milholland J, Rosen F. Inhibition of glucose uptake in lymphosarcoma P1798 by cortisol and its relationship to the biosynthesis of deoxyribonucleic acid. J Biol Chem. 1970 Apr 25; 245(8):2074-80. PMID: 5467455.
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    241. Rosen JM, Rosen F, Milholland RJ, Nichol CA. Effects of cortisol on DNA metabolism in the sensitive and resistant lines of mouse lymphoma P1798. Cancer Res. 1970 Apr; 30(4):1129-36. PMID: 5504353.
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