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JASON L. ERIKSEN

TitleAssociate Professor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
Address557A Science and Research Building 2
Houston TX 77204-5037
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    Alzheimer
    neurodegeneration
    tauopathy
    neuroscience


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tanifum EA, Ghaghada K, Vollert C, Head E, Eriksen JL. A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. J Alzheimers Dis. 2016 Oct 4; 54(3):1251. PMID: 27716679.
      View in: PubMed
    2. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    3. Tanifum EA, Ghaghada K, Vollert C, Head E, Eriksen JL, Annapragada A. A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. J Alzheimers Dis. 2016; 52(2):731-45. PMID: 27031484.
      View in: PubMed
    4. Manchandani P, Zhou J, Ledesma KR, Truong LD, Chow DS, Eriksen JL, Tam VH. Characterization of Polymyxin B Bio-distribution and Disposition in an Animal Model. Antimicrob Agents Chemother. 2015 Dec 7. PMID: 26643340.
      View in: PubMed
    5. Vollert CT, Moree WJ, Gregory S, Bark SJ, Eriksen JL. Formaldehyde scavengers function as novel antigen retrieval agents. Sci Rep. 2015; 5:17322. PMID: 26612041.
      View in: PubMed
    6. Ohia-Nwoko O, Montazari S, Lau YS, Eriksen JL. Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice. Mol Neurodegener. 2014; 9:54. PMID: 25432085; PMCID: PMC4280713.
    7. Dao AT, Zagaar MA, Salim S, Eriksen JL, Alkadhi KA. Regular exercise prevents non-cognitive disturbances in a rat model of Alzheimer's disease. Int J Neuropsychopharmacol. 2014 Apr; 17(4):593-602. PMID: 24229510; PMCID: PMC4097602.
    8. Hoshino A, Helwig M, Rezaei S, Berridge C, Eriksen JL, Lindberg I. A novel function for proSAAS as an amyloid anti-aggregant in Alzheimer's disease. J Neurochem. 2014 Feb; 128(3):419-30. PMID: 24102330; PMCID: PMC3946950.
    9. Vollert C, Ohia O, Akasaka H, Berridge C, Ruan KH, Eriksen JL. Elevated prostacyclin biosynthesis in mice impacts memory and anxiety-like behavior. Behav Brain Res. 2014 Jan 1; 258:138-44. PMID: 24140503; PMCID: PMC3849419.
    10. Vollert C, Forkuo GS, Bond RA, Eriksen JL. Chronic treatment with DCPCX, an adenosine A(1) antagonist, worsens long-term memory. Neurosci Lett. 2013 Aug 26; 548:296-300. PMID: 23748072; PMCID: PMC3722854.
    11. Dao AT, Zagaar MA, Levine AT, Salim S, Eriksen JL, Alkadhi KA. Treadmill exercise prevents learning and memory impairment in Alzheimer's disease-like pathology. Curr Alzheimer Res. 2013 Jun; 10(5):507-15. PMID: 23627709; PMCID: PMC4004077.
    12. Hazra A, Gu F, Aulakh A, Berridge C, Eriksen JL, Ziburkus J. Inhibitory neuron and hippocampal circuit dysfunction in an aged mouse model of Alzheimer's disease. PLoS One. 2013; 8(5):e64318. PMID: 23691195; PMCID: PMC3656838.
    13. Thanawala VJ, Forkuo GS, Al-Sawalha N, Azzegagh Z, Nguyen LP, Eriksen JL, Tuvim MJ, Lowder TW, Dickey BF, Knoll BJ, Walker JK, Bond RA. ?2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model. Am J Respir Cell Mol Biol. 2013 Feb; 48(2):220-9. PMID: 23204390; PMCID: PMC3604060.
    14. Helwig M, Hoshino A, Berridge C, Lee SN, Lorenzen N, Otzen DE, Eriksen JL, Lindberg I. The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins. J Biol Chem. 2013 Jan 11; 288(2):1114-24. PMID: 23172224; PMCID: PMC3542996.
    15. Tanifum EA, Dasgupta I, Srivastava M, Bhavane RC, Sun L, Berridge J, Pourgarzham H, Kamath R, Espinosa G, Cook SC, Eriksen JL, Annapragada A. Intravenous delivery of targeted liposomes to amyloid-? pathology in APP/PSEN1 transgenic mice. PLoS One. 2012; 7(10):e48515. PMID: 23119043; PMCID: PMC3485335.
    16. Alkadhi K, Eriksen J. The complex and multifactorial nature of Alzheimer's disease. Curr Neuropharmacol. 2011 Dec; 9(4):586. PMID: 22654718; PMCID: PMC3263454.
    17. Sun L, Eriksen JL. Recent insights into the involvement of progranulin in frontotemporal dementia. Curr Neuropharmacol. 2011 Dec; 9(4):632-42. PMID: 22654721; PMCID: PMC3263457.
    18. Schils RL, Eriksen J, Ledgard SF, Vellinga TV, Kuikman PJ, Luo J, Petersen SO, Velthof GL. Strategies to mitigate nitrous oxide emissions from herbivore production systems. Animal. 2013 Mar; 7 Suppl 1:29-40. PMID: 23031718.
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    19. Eriksen JL. The enigmatic roles of microglial versus neuronal progranulin in neurological disease. Acta Neuropathol. 2010 Jan; 119(1):107-9. PMID: 20012633.
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    20. Cook C, Gass J, Dunmore J, Tong J, Taylor J, Eriksen J, McGowan E, Lewis J, Johnston J, Petrucelli L. Aging is not associated with proteasome impairment in UPS reporter mice. PLoS One. 2009; 4(6):e5888. PMID: 19517018; PMCID: PMC2690827.
    21. Rademakers R, Eriksen JL, Baker M, Robinson T, Ahmed Z, Lincoln SJ, Finch N, Rutherford NJ, Crook RJ, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Parisi JE, Caselli RJ, Wszolek ZK, Uitti RJ, Feldman H, Hutton ML, Mackenzie IR, Graff-Radford NR, Dickson DW. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Hum Mol Genet. 2008 Dec 1; 17(23):3631-42. PMID: 18723524; PMCID: PMC2581433.
    22. Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Substrate-targeting gamma-secretase modulators. Nature. 2008 Jun 12; 453(7197):925-9. PMID: 18548070; PMCID: PMC2678541.
    23. Eriksen JL, Mackenzie IR. Progranulin: normal function and role in neurodegeneration. J Neurochem. 2008 Jan; 104(2):287-97. PMID: 17953663.
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    24. Weggen S, Rogers M, Eriksen J. NSAIDs: small molecules for prevention of Alzheimer's disease or precursors for future drug development? Trends Pharmacol Sci. 2007 Oct; 28(10):536-43. PMID: 17900710.
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    25. Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 2007; 8:54. PMID: 17650315; PMCID: PMC1948891.
    26. Eriksen JL, Janus CG. Plaques, tangles, and memory loss in mouse models of neurodegeneration. Behav Genet. 2007 Jan; 37(1):79-100. PMID: 17072762.
      View in: PubMed
    27. Amtul Z, Kausar N, Follmer C, Rozmahel RF. Cysteine based novel noncompetitive inhibitors of urease(s)--distinctive inhibition susceptibility of microbial and plant ureases. Bioorg Med Chem. 2006 Oct 1; 14(19):6737-44. PMID: 16859909.
      View in: PubMed
    28. Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, Dickson D, Berger Z, Eriksen J, Robinson T, Zehr C, Dickey CA, Crook R, McGowan E, Mann D, Boeve B, Feldman H, Hutton M. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 2006 Aug 24; 442(7105):916-9. PMID: 16862116.
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    29. Le Corre S, Klafki HW, Plesnila N, Hübinger G, Obermeier A, Sahagún H, Monse B, Seneci P, Lewis J, Eriksen J, Zehr C, Yue M, McGowan E, Dickson DW, Hutton M, Roder HM. An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice. Proc Natl Acad Sci U S A. 2006 Jun 20; 103(25):9673-8. PMID: 16769887; PMCID: PMC1480465.
    30. McGowan E, Eriksen J, Hutton M. A decade of modeling Alzheimer's disease in transgenic mice. Trends Genet. 2006 May; 22(5):281-9. PMID: 16567017.
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    31. McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, Delucia M, Lin WL, Dolios G, Wang R, Eckman CB, Dickson DW, Hutton M, Hardy J, Golde T. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 2005 Jul 21; 47(2):191-9. PMID: 16039562; PMCID: PMC1373682.
    32. Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo EH, Golde TE. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nat Med. 2005 May; 11(5):545-50. PMID: 15834426.
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    33. Dickey CA, Eriksen J, Kamal A, Burrows F, Kasibhatla S, Eckman CB, Hutton M, Petrucelli L. Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors. Curr Alzheimer Res. 2005 Apr; 2(2):231-8. PMID: 15974923.
      View in: PubMed
    34. Eriksen JL, Wszolek Z, Petrucelli L. Molecular pathogenesis of Parkinson disease. Arch Neurol. 2005 Mar; 62(3):353-7. PMID: 15767499.
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    35. Eriksen JL, Przedborski S, Petrucelli L. Gene dosage and pathogenesis of Parkinson's disease. Trends Mol Med. 2005 Mar; 11(3):91-6. PMID: 15760766.
      View in: PubMed
    36. Eriksen JL, Dawson TM, Dickson DW, Petrucelli L. Caught in the act: alpha-synuclein is the culprit in Parkinson's disease. Neuron. 2003 Oct 30; 40(3):453-6. PMID: 14642269.
      View in: PubMed
    37. Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest. 2003 Aug; 112(3):440-9. PMID: 12897211; PMCID: PMC166298.
    38. Sagi SA, Weggen S, Eriksen J, Golde TE, Koo EH. The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production. J Biol Chem. 2003 Aug 22; 278(34):31825-30. PMID: 12805355.
      View in: PubMed
    39. Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Ozols V, Fauq A, Golde TE, Koo EH. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem. 2003 Aug 22; 278(34):31831-7. PMID: 12805356.
      View in: PubMed
    40. Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Golde TE, Koo EH. Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem. 2003 Aug 15; 278(33):30748-54. PMID: 12777371.
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    41. Tajuddin NF, Orrico LA, Eriksen JL, Druse MJ. Effects of ethanol and ipsapirone on the development of midline raphe glial cells and astrocytes. Alcohol. 2003 Apr; 29(3):157-64. PMID: 12798971.
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    42. Eriksen JL, Gillespie R, Druse MJ. Effects of ethanol and 5-HT1A agonists on astroglial S100B. Brain Res Dev Brain Res. 2002 Dec 15; 139(2):97-105. PMID: 12480124.
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    43. Eriksen JL, Druse MJ. Astrocyte-mediated trophic support of developing serotonin neurons: effects of ethanol, buspirone, and S100B. Brain Res Dev Brain Res. 2001 Nov 26; 131(1-2):9-15. PMID: 11718831.
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    44. Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature. 2001 Nov 8; 414(6860):212-6. PMID: 11700559.
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    45. Eriksen JL, Druse MJ. Potential involvement of S100B in the protective effects of a serotonin-1a agonist on ethanol-treated astrocytes. Brain Res Dev Brain Res. 2001 Jun 29; 128(2):157-64. PMID: 11412901.
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    46. Eriksen JL, Gillespie RA, Druse MJ. Effects of in utero ethanol exposure and maternal treatment with a 5-HT(1A) agonist on S100B-containing glial cells. Brain Res Dev Brain Res. 2000 Jun 30; 121(2):133-43. PMID: 10876026.
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    47. Druse MJ, Hao HL, Eriksen JL. In utero ethanol exposure increases proenkephalin, a precursor of a neuropeptide that is inhibitory to neuronal growth. Alcohol Clin Exp Res. 1999 Sep; 23(9):1519-27. PMID: 10512319.
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    48. Gillespie RA, Eriksen J, Hao HL, Druse MJ. Effects of maternal ethanol consumption and buspirone treatment on dopamine and norepinephrine reuptake sites and D1 receptors in offspring. Alcohol Clin Exp Res. 1997 May; 21(3):452-9. PMID: 9161605.
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    49. Keiding S, Badsberg JH, Becker U, Bentsen KD, Bonnevie O, Caballeria J, Eriksen J, Hardt F, Keiding N, Morgan M, et al. The prognosis of patients with alcoholic liver disease. An international randomized, placebo-controlled trial on the effect of malotilate on survival. J Hepatol. 1994 Apr; 20(4):454-60. PMID: 8051381.
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