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FRANCIS T.F. TSAI

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
DivisionBiochemistry & Molecular Biology
AddressBIOCHEM & MOLEC BIOL, BCM 315B
ONE BAYLOR PLAZA
HOUSTON TX 770303498
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology


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    2008Norman Hackerman Award in Chemical Research, Welch Foundation

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chang CW, Lee S, Tsai FTF. Structural Elements Regulating AAA+ Protein Quality Control Machines. Front Mol Biosci. 2017; 4:27. PMID: 28523272.
      View in: PubMed
    2. Sung N, Lee J, Kim JH, Chang C, Tsai FT, Lee S. 2.4?Å resolution crystal structure of human TRAP1NM, the Hsp90 paralog in the mitochondrial matrix. Acta Crystallogr D Struct Biol. 2016 Aug 1; 72(Pt 8):904-11. PMID: 27487821; PMCID: PMC4973209 [Available on 08/01/17].
    3. Sung N, Lee J, Kim JH, Chang C, Joachimiak A, Lee S, Tsai FT. Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate. Proc Natl Acad Sci U S A. 2016 Feb 29. PMID: 26929380.
      View in: PubMed
    4. Saliba J, Zabriskie R, Ghosh R, Powell BC, Hicks S, Kimmel M, Meng Q, Ritter DI, Wheeler DA, Gibbs RA, Tsai FT, Plon SE. Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs. Pharmacogenet Genomics. 2016 Feb 22. PMID: 26906009.
      View in: PubMed
    5. Jeng W, Lee S, Sung N, Lee J, Tsai FT. Molecular chaperones: guardians of the proteome in normal and disease states. F1000Res. 2015; 4. PMID: 26918154.
      View in: PubMed
    6. Lee J, Kim JH, Biter AB, Sielaff B, Lee S, Tsai FT. Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8513-8. PMID: 23650362; PMCID: PMC3666692.
    7. Biter AB, Lee S, Sung N, Tsai FT. Structural basis for intersubunit signaling in a protein disaggregating machine. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12515-20. PMID: 22802670; PMCID: PMC3411974.
    8. Biter AB, Lee J, Sung N, Tsai FT, Lee S. Functional analysis of conserved cis- and trans-elements in the Hsp104 protein disaggregating machine. J Struct Biol. 2012 Aug; 179(2):172-80. PMID: 22634726; PMCID: PMC3411918.
    9. Lee S, Augustin S, Tatsuta T, Gerdes F, Langer T, Tsai FT. Electron cryomicroscopy structure of a membrane-anchored mitochondrial AAA protease. J Biol Chem. 2011 Feb 11; 286(6):4404-11. PMID: 21147776; PMCID: PMC3039362.
    10. Sielaff B, Lee KS, Tsai FT. Structural and functional conservation of Mycobacterium tuberculosis GroEL paralogs suggests that GroEL1 Is a chaperonin. J Mol Biol. 2011 Jan 21; 405(3):831-9. PMID: 21094166; PMCID: PMC3017675.
    11. Sielaff B, Tsai FT. The M-domain controls Hsp104 protein remodeling activity in an Hsp70/Hsp40-dependent manner. J Mol Biol. 2010 Sep 10; 402(1):30-7. PMID: 20654624; PMCID: PMC2938849.
    12. Lee S, Sielaff B, Lee J, Tsai FT. CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation. Proc Natl Acad Sci U S A. 2010 May 4; 107(18):8135-40. PMID: 20404203; PMCID: PMC2889573.
    13. Augustin S, Gerdes F, Lee S, Tsai FT, Langer T, Tatsuta T. An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases. Mol Cell. 2009 Sep 11; 35(5):574-85. PMID: 19748354; PMCID: PMC2744646.
    14. Lee S, Tsai FT. Crystallization and preliminary X-ray crystallographic analysis of a 40 kDa N-terminal fragment of the yeast prion-remodeling factor Hsp104. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Sep 1; 63(Pt 9):784-6. PMID: 17768355; PMCID: PMC2376311.
    15. Lee S, Choi JM, Tsai FT. Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB. Mol Cell. 2007 Jan 26; 25(2):261-71. PMID: 17244533; PMCID: PMC1855157.
    16. Haslberger T, Weibezahn J, Zahn R, Lee S, Tsai FT, Bukau B, Mogk A. M domains couple the ClpB threading motor with the DnaK chaperone activity. Mol Cell. 2007 Jan 26; 25(2):247-60. PMID: 17244532.
      View in: PubMed
    17. Zhang J, Tsai FT, Geller DS. Differential interaction of RU486 with the progesterone and glucocorticoid receptors. J Mol Endocrinol. 2006 Aug; 37(1):163-73. PMID: 16901932.
      View in: PubMed
    18. Rees I, Lee S, Kim H, Tsai FT. The E3 ubiquitin ligase CHIP binds the androgen receptor in a phosphorylation-dependent manner. Biochim Biophys Acta. 2006 Jun; 1764(6):1073-9. PMID: 16725394.
      View in: PubMed
    19. Lee S, Tsai FT. Molecular chaperones in protein quality control. J Biochem Mol Biol. 2005 May 31; 38(3):259-65. PMID: 15943899.
      View in: PubMed
    20. Zhang J, Simisky J, Tsai FT, Geller DS. A critical role of helix 3-helix 5 interaction in steroid hormone receptor function. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2707-12. PMID: 15710879; PMCID: PMC549476.
    21. Weibezahn J, Tessarz P, Schlieker C, Zahn R, Maglica Z, Lee S, Zentgraf H, Weber-Ban EU, Dougan DA, Tsai FT, Mogk A, Bukau B. Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB. Cell. 2004 Nov 24; 119(5):653-65. PMID: 15550247.
      View in: PubMed
    22. Lee S, Hisayoshi M, Yoshida M, Tsai FT. Crystallization and preliminary X-ray crystallographic analysis of the Hsp100 chaperone ClpB from Thermus thermophilus. Acta Crystallogr D Biol Crystallogr. 2003 Dec; 59(Pt 12):2334-6. PMID: 14646112.
      View in: PubMed
    23. Lee S, Sowa ME, Watanabe YH, Sigler PB, Chiu W, Yoshida M, Tsai FT. The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state. Cell. 2003 Oct 17; 115(2):229-40. PMID: 14567920.
      View in: PubMed
    24. Geller DS, Farhi A, Pinkerton N, Fradley M, Moritz M, Spitzer A, Meinke G, Tsai FT, Sigler PB, Lifton RP. Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science. 2000 Jul 7; 289(5476):119-23. PMID: 10884226.
      View in: PubMed
    25. Tsai FT, Sigler PB. Structural basis of preinitiation complex assembly on human pol II promoters. EMBO J. 2000 Jan 4; 19(1):25-36. PMID: 10619841; PMCID: PMC1171774.
    26. Tsai FT, Littlefield O, Kosa PF, Cox JM, Schepartz A, Sigler PB. Polarity of transcription on Pol II and archaeal promoters: where is the "one-way sign" and how is it read? Cold Spring Harb Symp Quant Biol. 1998; 63:53-61. PMID: 10384270.
      View in: PubMed
    27. Tsai FT, Singh OM, Skarzynski T, Wonacott AJ, Weston S, Tucker A, Pauptit RA, Breeze AL, Poyser JP, O'Brien R, Ladbury JE, Wigley DB. The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin. Proteins. 1997 May; 28(1):41-52. PMID: 9144789.
      View in: PubMed
    28. Tsai FT, Subramanya HS, Brannigan JA, Wilkinson AJ, Wigley DB. Crystallization and preliminary crystallographic analysis of the DNA gyrase B protein from B. stearothermophilus. Acta Crystallogr D Biol Crystallogr. 1996 Nov 1; 52(Pt 6):1216-8. PMID: 15299591.
      View in: PubMed
    29. Lewis RJ, Tsai FT, Wigley DB. Molecular mechanisms of drug inhibition of DNA gyrase. Bioessays. 1996 Aug; 18(8):661-71. PMID: 8760340.
      View in: PubMed
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