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SALIH J WAKIL

TitleChair Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
DivisionBiochemistry & Molecular Biology
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleDistinguished Service Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry & Molecular Biology
    DivisionBiochemistry & Molecular Biology


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    1. Abu-Elheiga L, Wu H, Gu Z, Bressler R, Wakil SJ. Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions. J Biol Chem. 2012 Apr 6; 287(15):12578-88. PMID: 22362781; PMCID: PMC3321006.
    2. Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ, Quiocho FA. Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15757-62. PMID: 21908709; PMCID: PMC3179057.
    3. Kamisuki S, Shirakawa T, Kugimiya A, Abu-Elheiga L, Choo HY, Yamada K, Shimogawa H, Wakil SJ, Uesugi M. Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem. 2011 Jul 14; 54(13):4923-7. PMID: 21561152; PMCID: PMC3136361.
    4. Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A. 2009 Nov 3; 106(44):18831-6. PMID: 19850873; PMCID: PMC2773998.
    5. Mao J, Yang T, Gu Z, Heird WC, Finegold MJ, Lee B, Wakil SJ. aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17576-81. PMID: 19805143; PMCID: PMC2762677.
    6. Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009 Aug 28; 16(8):882-92. PMID: 19716478.
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    7. Wakil SJ, Abu-Elheiga LA. Fatty acid metabolism: target for metabolic syndrome. J Lipid Res. 2009 Apr; 50 Suppl:S138-43. PMID: 19047759; PMCID: PMC2674721.
    8. Essop MF, Camp HS, Choi CS, Sharma S, Fryer RM, Reinhart GA, Guthrie PH, Bentebibel A, Gu Z, Shulman GI, Taegtmeyer H, Wakil SJ, Abu-Elheiga L. Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice. Am J Physiol Heart Circ Physiol. 2008 Jul; 295(1):H256-65. PMID: 18487439; PMCID: PMC2494759.
    9. Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16480-5. PMID: 17923673; PMCID: PMC2034222.
    10. Mao J, DeMayo FJ, Li H, Abu-Elheiga L, Gu Z, Shaikenov TE, Kordari P, Chirala SS, Heird WC, Wakil SJ. Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8552-7. PMID: 16717184; PMCID: PMC1570106.
    11. Abu-Elheiga L, Matzuk MM, Kordari P, Oh W, Shaikenov T, Gu Z, Wakil SJ. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12011-6. PMID: 16103361; PMCID: PMC1189351.
    12. Oh W, Abu-Elheiga L, Kordari P, Gu Z, Shaikenov T, Chirala SS, Wakil SJ. Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice. Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5):1384-9. PMID: 15677334; PMCID: PMC547858.
    13. Chirala SS, Wakil SJ. Structure and function of animal fatty acid synthase. Lipids. 2004 Nov; 39(11):1045-53. PMID: 15726818.
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    14. Chakravarty B, Gu Z, Chirala SS, Wakil SJ, Quiocho FA. Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain. Proc Natl Acad Sci U S A. 2004 Nov 2; 101(44):15567-72. PMID: 15507492; PMCID: PMC524853.
    15. Brink J, Ludtke SJ, Kong Y, Wakil SJ, Ma J, Chiu W. Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis. Structure. 2004 Feb; 12(2):185-91. PMID: 14962379.
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    16. Beinert H, Stumpf PK, Wakil SJ. David Ezra Green. Biogr Mem Natl Acad Sci. 2004; 84:112-44. PMID: 15484418.
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    17. Abu-Elheiga L, Oh W, Kordari P, Wakil SJ. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets. Proc Natl Acad Sci U S A. 2003 Sep 2; 100(18):10207-12. PMID: 12920182; PMCID: PMC193540.
    18. Mao J, Chirala SS, Wakil SJ. Human acetyl-CoA carboxylase 1 gene: presence of three promoters and heterogeneity at the 5'-untranslated mRNA region. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7515-20. PMID: 12810950; PMCID: PMC164618.
    19. Chirala SS, Chang H, Matzuk M, Abu-Elheiga L, Mao J, Mahon K, Finegold M, Wakil SJ. Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6358-63. PMID: 12738878; PMCID: PMC164451.
    20. Al-Feel W, DeMar JC, Wakil SJ. A Saccharomyces cerevisiae mutant strain defective in acetyl-CoA carboxylase arrests at the G2/M phase of the cell cycle. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3095-100. PMID: 12626751; PMCID: PMC152252.
    21. Ming D, Kong Y, Wakil SJ, Brink J, Ma J. Domain movements in human fatty acid synthase by quantized elastic deformational model. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):7895-9. PMID: 12060737; PMCID: PMC122991.
    22. Brink J, Ludtke SJ, Yang CY, Gu ZW, Wakil SJ, Chiu W. Quaternary structure of human fatty acid synthase by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2002 Jan 8; 99(1):138-43. PMID: 11756679; PMCID: PMC117528.
    23. Abu-Elheiga L, Matzuk MM, Abo-Hashema KA, Wakil SJ. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 2001 Mar 30; 291(5513):2613-6. PMID: 11283375.
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    24. Chirala SS, Jayakumar A, Gu ZW, Wakil SJ. Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3104-8. PMID: 11248039; PMCID: PMC30614.
    25. Xiong S, Chirala SS, Wakil SJ. Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):3948-53. PMID: 10759542; PMCID: PMC18122.
    26. Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G, Wakil SJ. The subcellular localization of acetyl-CoA carboxylase 2. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1444-9. PMID: 10677481; PMCID: PMC26453.
    27. Xiong S, Chirala SS, Hsu MH, Wakil SJ. Identification of thyroid hormone response elements in the human fatty acid synthase promoter. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12260-5. PMID: 9770474; PMCID: PMC22819.
    28. Jayakumar A, Chirala SS, Wakil SJ. Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase subunit protein reconstitutes enzyme activity. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12326-30. PMID: 9356448; PMCID: PMC24928.
    29. Chirala SS, Huang WY, Jayakumar A, Sakai K, Wakil SJ. Animal fatty acid synthase: functional mapping and cloning and expression of the domain I constituent activities. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5588-93. PMID: 9159116; PMCID: PMC20822.
    30. Abu-Elheiga L, Almarza-Ortega DB, Baldini A, Wakil SJ. Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms. J Biol Chem. 1997 Apr 18; 272(16):10669-77. PMID: 9099716.
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    31. Jayakumar A, Huang WY, Raetz B, Chirala SS, Wakil SJ. Cloning and expression of the multifunctional human fatty acid synthase and its subdomains in Escherichia coli. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14509-14. PMID: 8962082; PMCID: PMC26163.
    32. Hsu MH, Chirala SS, Wakil SJ. Human fatty-acid synthase gene. Evidence for the presence of two promoters and their functional interaction. J Biol Chem. 1996 Jun 7; 271(23):13584-92. PMID: 8662758.
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    33. Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ. Human fatty acid synthase: properties and molecular cloning. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8695-9. PMID: 7567999; PMCID: PMC41033.
    34. Abu-Elheiga L, Jayakumar A, Baldini A, Chirala SS, Wakil SJ. Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms. Proc Natl Acad Sci U S A. 1995 Apr 25; 92(9):4011-5. PMID: 7732023; PMCID: PMC42092.
    35. Huang WY, Chirala SS, Wakil SJ. Amino-terminal blocking group and sequence of the animal fatty acid synthase. Arch Biochem Biophys. 1994 Oct; 314(1):45-9. PMID: 7944406.
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    36. Jayakumar A, Chirala SS, Chinault AC, Baldini A, Abu-Elheiga L, Wakil SJ. Isolation and chromosomal mapping of genomic clones encoding the human fatty acid synthase gene. Genomics. 1994 Sep 15; 23(2):420-4. PMID: 7835891.
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    37. Mohamed AH, Huang WY, Huang W, Venkatachalam KV, Wakil SJ. Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver. J Biol Chem. 1994 Mar 4; 269(9):6859-65. PMID: 7907095.
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    38. Tai MH, Chirala SS, Wakil SJ. Roles of Ser101, Asp236, and His237 in catalysis of thioesterase II and of the C-terminal region of the enzyme in its interaction with fatty acid synthase. Proc Natl Acad Sci U S A. 1993 Mar 1; 90(5):1852-6. PMID: 8446599; PMCID: PMC45978.
    39. Stoops JK, Kolodziej SJ, Schroeter JP, Bretaudiere JP, Wakil SJ. Structure-function relationships of the yeast fatty acid synthase: negative-stain, cryo-electron microscopy, and image analysis studies of the end views of the structure. Proc Natl Acad Sci U S A. 1992 Jul 15; 89(14):6585-9. PMID: 1631160; PMCID: PMC49546.
    40. Al-Feel W, Chirala SS, Wakil SJ. Cloning of the yeast FAS3 gene and primary structure of yeast acetyl-CoA carboxylase. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4534-8. PMID: 1350093; PMCID: PMC49117.
    41. Pazirandeh M, Chirala SS, Wakil SJ. Site-directed mutagenesis studies on the recombinant thioesterase domain of chicken fatty acid synthase expressed in Escherichia coli. J Biol Chem. 1991 Nov 5; 266(31):20946-52. PMID: 1939144.
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    42. Stoops JK, Singh N, Wakil SJ. The yeast fatty acid synthase. Pathway for transfer of the acetyl group from coenzyme A to the Cys-SH of the condensation site. J Biol Chem. 1990 Oct 5; 265(28):16971-7. PMID: 2211602.
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    43. Mabrouk GM, Helmy IM, Thampy KG, Wakil SJ. Acute hormonal control of acetyl-CoA carboxylase. The roles of insulin, glucagon, and epinephrine. J Biol Chem. 1990 Apr 15; 265(11):6330-8. PMID: 1969410.
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    44. Pazirandeh M, Chirala SS, Huang WY, Wakil SJ. Characterization of recombinant thioesterase and acyl carrier protein domains of chicken fatty acid synthase expressed in Escherichia coli. J Biol Chem. 1989 Oct 25; 264(30):18195-201. PMID: 2681189.
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    45. Wakil SJ. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry. 1989 May 30; 28(11):4523-30. PMID: 2669958.
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    46. Huang WY, Stoops JK, Wakil SJ. Complete amino acid sequence of chicken liver acyl carrier protein derived from the fatty acid synthase. Arch Biochem Biophys. 1989 Apr; 270(1):92-8. PMID: 2648999.
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    47. Chirala SS, Kasturi R, Pazirandeh M, Stolow DT, Huang WY, Wakil SJ. A novel cDNA extension procedure. Isolation of chicken fatty acid synthase cDNA clones. J Biol Chem. 1989 Mar 5; 264(7):3750-7. PMID: 2917973.
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    48. Tsukamoto Y, Wakil SJ. Isolation and mapping of the beta-hydroxyacyl dehydratase activity of chicken liver fatty acid synthase. J Biol Chem. 1988 Nov 5; 263(31):16225-9. PMID: 3182791.
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    49. Yang CY, Huang WY, Chirala S, Wakil SJ. Complete amino acid sequence of the thioesterase domain of chicken liver fatty acid synthase. Biochemistry. 1988 Oct 4; 27(20):7773-7. PMID: 3207709.
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    50. Kasturi R, Chirala S, Pazirandeh M, Wakil SJ. Characterization of a genomic and cDNA clone coding for the thioesterase domain and 3' noncoding region of the chicken liver fatty acid synthase gene. Biochemistry. 1988 Oct 4; 27(20):7778-85. PMID: 3207710.
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    51. Thampy KG, Huang WY, Wakil SJ. A rapid purification method for rat liver pyruvate carboxylase and amino acid sequence analyses of NH2-terminal and biotin peptide. Arch Biochem Biophys. 1988 Oct; 266(1):270-6. PMID: 3178228.
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    52. Mohamed AH, Chirala SS, Mody NH, Huang WY, Wakil SJ. Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence. J Biol Chem. 1988 Sep 5; 263(25):12315-25. PMID: 2900835.
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    53. Thampy KG, Wakil SJ. Regulation of acetyl-coenzyme A carboxylase. II. Effect of fasting and refeeding on the activity, phosphate content, and aggregation state of the enzyme. J Biol Chem. 1988 May 5; 263(13):6454-8. PMID: 2896194.
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    54. Thampy KG, Wakil SJ. Regulation of acetyl-coenzyme A carboxylase. I. Purification and properties of two forms of acetyl-coenzyme A carboxylase from rat liver. J Biol Chem. 1988 May 5; 263(13):6447-53. PMID: 2896193.
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    55. Stoops JK, Wakil SJ, Uberbacher EC, Bunick GJ. Small-angle neutron-scattering and electron microscope studies of the chicken liver fatty acid synthase. J Biol Chem. 1987 Jul 25; 262(21):10246-51. PMID: 3611059.
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    56. Chirala SS, Kuziora MA, Spector DM, Wakil SJ. Complementation of mutations and nucleotide sequence of FAS1 gene encoding beta subunit of yeast fatty acid synthase. J Biol Chem. 1987 Mar 25; 262(9):4231-40. PMID: 3031066.
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    57. Chirala SS, Wakil SJ. Radio-labeling of the PstI restriction fragments and improvement in the sequencing procedure. Gene. 1986; 47(2-3):297-300. PMID: 3030892.
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    58. Wakil SJ. The relationship between structure and function for and the regulation of the enzymes of fatty acid synthesis. Ann N Y Acad Sci. 1986; 478:203-19. PMID: 2879500.
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    59. Singh N, Wakil SJ, Stoops JK. Yeast fatty acid synthase: structure to function relationship. Biochemistry. 1985 Nov 5; 24(23):6598-602. PMID: 3910094.
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    60. Singh N, Wakil SJ, Stoops JK. The development and application of a novel chromophoric substrate for investigation of the mechanism of yeast fatty acid synthase. Biochem Biophys Res Commun. 1985 Sep 16; 131(2):786-92. PMID: 3902014.
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    61. Thampy KG, Wakil SJ. Activation of acetyl-CoA carboxylase. Purification and properties of a Mn2+-dependent phosphatase. J Biol Chem. 1985 May 25; 260(10):6318-23. PMID: 2860106.
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    62. Kasturi R, Joshi VC, Wakil SJ. Colchicine inhibition of insulin induction of stearoyl-CoA desaturase and fatty acid synthetase in cultured avian liver explants. Arch Biochem Biophys. 1984 Sep; 233(2):530-9. PMID: 6148915.
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    63. Singh N, Wakil SJ, Stoops JK. On the question of half- or full-site reactivity of animal fatty acid synthetase. J Biol Chem. 1984 Mar 25; 259(6):3605-11. PMID: 6706971.
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    64. Yang CY, Wakil SJ. Separation of dimethylaminoazobenzenethiohydantoin amino acids by high-performance liquid chromatography at low picomole concentrations. Anal Biochem. 1984 Feb; 137(1):54-7. PMID: 6428264.
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    65. Wong H, Mattick JS, Wakil SJ. The architecture of the animal fatty acid synthetase. III. Isolation and characterization of beta-ketoacyl reductase. J Biol Chem. 1983 Dec 25; 258(24):15305-11. PMID: 6361031.
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    66. Mattick JS, Nickless J, Mizugaki M, Yang CY, Uchiyama S, Wakil SJ. The architecture of the animal fatty acid synthetase. II. Separation of the core and thioesterase functions and determination of the N-C orientation of the subunit. J Biol Chem. 1983 Dec 25; 258(24):15300-4. PMID: 6654913.
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    67. Mattick JS, Tsukamoto Y, Nickless J, Wakil SJ. The architecture of the animal fatty acid synthetase. I. Proteolytic dissection and peptide mapping. J Biol Chem. 1983 Dec 25; 258(24):15291-9. PMID: 6361030.
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    68. Tsukamoto Y, Wong H, Mattick JS, Wakil SJ. The architecture of the animal fatty acid synthetase complex. IV. Mapping of active centers and model for the mechanism of action. J Biol Chem. 1983 Dec 25; 258(24):15312-22. PMID: 6654914.
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    69. Stoops JK, Henry SJ, Wakil SJ. The arrangement and role of some of the amino acid residues in the beta-ketoacyl synthetase site of chicken liver fatty acid synthetase. J Biol Chem. 1983 Oct 25; 258(20):12482-6. PMID: 6630195.
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    70. Kuziora MA, Chalmers JH, Douglas MG, Hitzeman RA, Mattick JS, Wakil SJ. Molecular cloning of fatty acid synthetase genes from Saccharomyces cerevisiae. J Biol Chem. 1983 Oct 10; 258(19):11648-53. PMID: 6311818.
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    71. Shoukry S, Stoops JK, Wakil SJ. Inactivation of yeast fatty acid synthetase by modifying the beta-ketoacyl reductase active lysine residue with pyridoxal 5'-phosphate. Arch Biochem Biophys. 1983 Oct 1; 226(1):224-30. PMID: 6416172.
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    72. Kasturi R, Wakil SJ. Increased synthesis and accumulation of phospholipids during differentiation of 3T3-L1 cells into adipocytes. J Biol Chem. 1983 Mar 25; 258(6):3559-64. PMID: 6833214.
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    73. Wakil SJ, Stoops JK, Joshi VC. Fatty acid synthesis and its regulation. Annu Rev Biochem. 1983; 52:537-79. PMID: 6137188.
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    74. Calabro MA, Prasad MR, Wakil SJ, Joshi VC. Stearoyl-coenzyme A desaturase activity in the mammary gland and liver of lactating rats. Lipids. 1982 Jun; 17(6):397-402. PMID: 6125866.
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    75. Stoops JK, Wakil SJ. Animal fatty acid synthetase. Identification of the residues comprising the novel arrangement of the beta-ketoacyl synthetase site and their role in its cold inactivation. J Biol Chem. 1982 Mar 25; 257(6):3230-5. PMID: 7061475.
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    76. Stoops JK, Wakil SJ. The reaction of chicken liver fatty acid synthetase with 5,5'-dithiobis(2-nitrobenzoic acid). Biochem Biophys Res Commun. 1982 Feb 11; 104(3):1018-24. PMID: 7073722.
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    77. Aprahamian SA, Arslanian MJ, Wakil SJ. Comparative studies on the kinetic parameters and product analyses of chicken and rat liver and yeast fatty acid synthetase. Comp Biochem Physiol B. 1982; 71(4):577-82. PMID: 7044669.
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    78. Stoops JK, Wakil SJ. The yeast fatty acid synthetase. Structure-function relationship and the role of the active cysteine-SH and pantetheine-SH. J Biol Chem. 1981 Aug 25; 256(16):8364-70. PMID: 7021548.
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    79. Wakil SJ, Stoops JK, Mattick JS. The fatty acid synthetase-structure-function relationship and mechanism of palmitate synthesis. Cardiovasc Res Cent Bull. 1981 Jul-Sep; 20(1):1-23. PMID: 7340934.
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    80. Stoops JK, Wakil SJ. Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits. J Biol Chem. 1981 May 25; 256(10):5128-33. PMID: 6112225.
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    81. Mattick JS, Zehner ZE, Calabro MA, Wakil SJ. The isolation and characterization of fatty-acid synthetase mRNA from rat mammary gland. Eur J Biochem. 1981 Mar; 114(3):643-51. PMID: 6113142.
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    82. Zehner ZE, Mattick JS, Stuart R, Wakil SJ. Goose fatty acid synthetase mRNA. J Biol Chem. 1980 Oct 25; 255(20):9519-22. PMID: 7430082.
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    83. Stoops JK, Wakil SJ. Yeast fatty acid synthetase: structure-function relationship and nature of the beta-ketoacyl synthetase site. Proc Natl Acad Sci U S A. 1980 Aug; 77(8):4544-8. PMID: 7001460; PMCID: PMC349880.
    84. Sreekrishna K, Gunsberg S, Wakil SJ, Joshi VC. Interaction of the fluorescent analogue stearoyl-(1,N6)-etheno coenzyme A with chicken liver acetyl coenzyme A carboxylase. J Biol Chem. 1980 Apr 25; 255(8):3348-51. PMID: 6102564.
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    85. Okuyama H, Saito M, Joshi VC, Gunsberg S, Wakil SJ. Regulation by temperature of the chain length of fatty acids in yeast. J Biol Chem. 1979 Dec 25; 254(24):12281-4. PMID: 387785.
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    86. Stoops JK, Ross P, Arslanian MJ, Aune KC, Wakil SJ, Oliver RM. Physicochemical studies of the rat liver and adipose fatty acid synthetases. J Biol Chem. 1979 Aug 10; 254(15):7418-26. PMID: 457689.
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    87. Stoops JK, Wakil SJ. The isolation of the two subunits of yeast fatty acid synthetase. Biochem Biophys Res Commun. 1978 Sep 14; 84(1):225-31. PMID: 365179.
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    88. Stoops JK, Awad ES, Arslanian MJ, Gunsberg S, Wakil SJ, Oliver RM. Studies on the yeast fatty acid synthetase. Subunit composition and structural organization of a large multifunctional enzyme complex. J Biol Chem. 1978 Jun 25; 253(12):4464-75. PMID: 350874.
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    89. Stoops JK, Arslanian MJ, Aune KC, Wakil SJ. Further evidence for the multifunctional enzyme characteristic of the fatty acid synthetases of animal tissues. Arch Biochem Biophys. 1978 Jun; 188(2):348-59. PMID: 677903.
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    90. Joshi VC, Wakil SJ. Hormonal regulation of hepatic fatty acid synthetase in chick embryo. Role of insulin. J Biol Chem. 1978 Apr 10; 253(7):2120-5. PMID: 416024.
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    91. Zehner ZE, Joshi VC, Wakil SJ. Regulation of fatty acid synthetase in perinatal chicks. Identification of polysomes synthesizing fatty acid synthetase. J Biol Chem. 1977 Oct 25; 252(20):7015-22. PMID: 332686.
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    92. Joshi VC, Wilson AC, Wakil SJ. Assay for the terminal enzyme of the stearoyl coenzyme A desaturase system using chick embryo liver microsomes. J Lipid Res. 1977 Jan; 18(1):32-6. PMID: 13132.
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    93. Wilson AC, Murtadha M, Wakil SJ. Fatty acid synthesis in aorta. Isolation of fatty acid synthetase from chicken aorta. Atherosclerosis. 1977 Jan; 26(1):103-15. PMID: 13803.
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    94. Arslanian MJ, Stoops JK, Oh YH, Wakil SJ. On the 4'-phosphopantetheine content of chicken and rat liver fatty acid synthetases. J Biol Chem. 1976 May 25; 251(10):3194-6. PMID: 1270444.
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    95. Okuyama H, Yamada K, Ikezawa H, Wakil SJ. Factors affecting the acyl selectivities of acyltransferases in Escherichia coli. J Biol Chem. 1976 Apr 25; 251(8):2487-92. PMID: 770468.
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    96. Wilson AC, Wakil SJ, Joshi VC. Induction of microsomal stearyl coenzyme A desaturase in the newly hatched chicks. Arch Biochem Biophys. 1976 Mar; 173(1):154-61. PMID: 4026.
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    97. Stoops JK, Arslanian MJ, Oh YH, Aune KC, Vanaman TC, Wakil SJ. Presence of two polypeptide chains comprising fatty acid synthetase. Proc Natl Acad Sci U S A. 1975 May; 72(5):1940-4. PMID: 1098047; PMCID: PMC432664.
    98. Arslanian MJ, Wakil SJ. Fatty acid synthase from chicken liver. Methods Enzymol. 1975; 35:59-65. PMID: 235706.
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    99. Okuyama H, Wakil SJ. Positional specificities of acyl coenzyme A: glycerophosphate and acyl coenzyme A: monoacylglycerophosphate acyltransferases in Escherichia coli. J Biol Chem. 1973 Jul 25; 248(14):5197-205. PMID: 4352195.
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    100. Crowfoot PD, Oka T, Esfahani M, Wakil SJ. Turnover of phospholipids in an unsaturated fatty acid auxotroph of Escherichia coli. J Bacteriol. 1972 Dec; 112(3):1396-407. PMID: 4629658; PMCID: PMC251577.
    101. Esfahani M, Crowfoot PD, Wakil SJ. Molecular organization of lipids in Escherichia coli membranes. II. Effect of phospholipids on succinic-ubiquinone reductase activity. J Biol Chem. 1972 Nov 25; 247(22):7251-6. PMID: 4565080.
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    102. Wakil SJ, Esfahani M. The role of lipids in the structure and function of E. coli membrane. Biochem Soc Symp. 1972; (35):395-405. PMID: 4614811.
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    103. Huxtable RJ, Wakil SJ. Comparative mitochondrial oxidation of fatty acids. Biochim Biophys Acta. 1971 Jul 13; 239(2):168-77. PMID: 5119255.
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    104. Joshi VC, Wakil SJ. Studies on the mechanism of fatty acid synthesis. XXVI. Purification and properties of malonyl-coenzyme A--acyl carrier protein transacylase of Escherichia coli. Arch Biochem Biophys. 1971 Apr; 143(2):493-505. PMID: 4934182.
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    105. Schulz H, Wakil SJ. Studies on the mechanism of fatty acid synthesis. XXV. On the mechanism of beta-ketoacylacyl carrier protein reductase from Escherichia coli. J Biol Chem. 1971 Mar 25; 246(6):1895-901. PMID: 4396098.
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    106. Esfahani M, Ioneda T, Wakil SJ. Studies on the control of fatty acid metabolism. 3. Incorporation of fatty acids into phospholipids and regulation of fatty acid synthetase of Escherichia coli. J Biol Chem. 1971 Jan 10; 246(1):50-6. PMID: 5541772.
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    107. Plate CA, Joshi VC, Wakil SJ. Studies on the mechanism of fatty acid synthesis. XXIV. The acetyl- and malonyltransacylase activities of pigeon liver fatty acid synthetase. J Biol Chem. 1970 Jun 10; 245(11):2868-75. PMID: 4912535.
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    108. Joshi VC, Plate CA, Wakil SJ. Studies on the mechanism of fatty acid synthesis. 23. The acyl binding sites of the pigeon liver fatty acid synthetase. J Biol Chem. 1970 Jun 10; 245(11):2857-67. PMID: 5423378.
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    109. Barnes EM, Wakil SJ, Swindell AC. Purification and properties of a palmityl thioesterase II from Escherichia coli. J Biol Chem. 1970 Jun; 245(12):3122-8. PMID: 4914740.
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    110. Weeks G, Wakil SJ. Studies on the control of fatty acid metabolism. II. The inhibition of fatty acid synthesis in Lactobacillus plantarum by exogenous fatty acid. J Biol Chem. 1970 Apr 25; 245(8):1913-21. PMID: 5440835.
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    111. Boone SC, Wakil SJ. In vitro synthesis of lignoceric and nervonic acids in mammalian liver and brain. Biochemistry. 1970 Mar 17; 9(6):1470-9. PMID: 4392137.
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    112. Schulz H, Weeks G, Toomey RE, Shapiro M, Wakil SJ. Studies on the mechanism of fatty acid synthesis. XXII. Salt activation of the fatty acid-synthesizing enzymes of Escherichia coli. J Biol Chem. 1969 Dec 25; 244(24):6577-83. PMID: 4902887.
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    113. Esfahani M, Barnes EM, Wakil SJ. Control of fatty acid composition in phospholipids of Escherichia coli: response to fatty acid supplements in a fatty acid auxotroph. Proc Natl Acad Sci U S A. 1969 Nov; 64(3):1057-64. PMID: 4905989; PMCID: PMC223343.
    114. Jones PD, Holloway PW, Peluffo RO, Wakil SJ. A requirement for lipids by the microsomal stearyl coenzyme A desaturase. J Biol Chem. 1969 Feb 25; 244(4):744-54. PMID: 4388795.
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    115. Weeks G, Shapiro M, Burns RO, Wakil SJ. Control of fatty acid metabolism. I. Induction of the enzymes of fatty acid oxidation in Escherichia coli. J Bacteriol. 1969 Feb; 97(2):827-36. PMID: 4886296; PMCID: PMC249767.
    116. Vanaman TC, Wakil SJ, Hill RL. The complete amino acid sequence of the acyl carrier protein of Escherichia coli. J Biol Chem. 1968 Dec 25; 243(24):6420-31. PMID: 4882207.
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    117. Vanaman TC, Wakil SJ, Hill RL. The preparation of tryptic, peptic, thermolysin, and cyanogen bromide peptides from the acyl carrier protein of Escherichia coli. J Biol Chem. 1968 Dec 25; 243(24):6409-19. PMID: 4882206.
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    118. Mizugaki M, Swindell AC, Wakil SJ. Intermediate- and long-chain beta-hydroxyacyl-ACP dehydrases from E. coli fatty acid synthetase. Biochem Biophys Res Commun. 1968 Nov 8; 33(3):520-7. PMID: 4881058.
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    119. Plate CA, Joshi VC, Sedgwick B, Wakil SJ. Studies on the mechanism of fatty acid synthesis. XXI. The role of fructose 1,6-diphosphate in the stimulation of the fatty acid synthetase from pigeon liver. J Biol Chem. 1968 Oct 25; 243(20):5439-45. PMID: 4302786.
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    120. Mizugaki M, Weeks G, Toomey RE, Wakil SJ. Studies on the mechanism of fatty acid synthesis. XX. Preparation and general properties of beta-hydroxybutyryl acyl carrier protein dehydrase. J Biol Chem. 1968 Jul 10; 243(13):3661-70. PMID: 5658542.
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    121. Barnes EM, Wakil SJ. Studies on the mechanism of fatty acid synthesis. XIX. Preparation and general properties of palmityl thioesterase. J Biol Chem. 1968 Jun 10; 243(11):2955-62. PMID: 4871199.
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    122. Weeks G, Wakil SJ. Studies on the mechanism of fatty acid synthesis. 18. Preparation and general properties of the enoyl acyl carrier protein reductases from Escherichia coli. J Biol Chem. 1968 Mar 25; 243(6):1180-9. PMID: 4384650.
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    123. Pugh EL, Sauer F, Waite M, Toomey RE, Wakil SJ. Studies on the mechanism of fatty acid synthesis. 13. The role of beta-hydroxy acids in the synthesis of palmitate and cis vaccenate by the Escherichia coli enzyme system. J Biol Chem. 1966 Jun 10; 241(11):2635-43. PMID: 4380382.
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    124. Williamson IP, Wakil SJ. Studies on the mechanism of fatty acid synthesis. XVII. Preparation and general properties of acetyl coenzyme A and malonyl coenzyme A-acyl carrier protein transacylases. J Biol Chem. 1966 May 25; 241(10):2326-32. PMID: 5330116.
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    125. Waite M, Wakil SJ. Studies on the mechanism of action of acetyl coenzyme A carboxylase. 3. Enzyme-bound 1'-N-carboxybiotin as the carboxylation intermediate. J Biol Chem. 1966 Apr 25; 241(8):1909-14. PMID: 5945861.
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    126. Toomey RE, Wakil SJ. Studies on the mechanism of fatty acid synthesis. XV. Preparation and general properties of beta-ketoacyl acyl carrier protein reductase from Escherichia coli. Biochim Biophys Acta. 1966 Apr 4; 116(2):189-97. PMID: 4381013.
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    127. Toomey RE, Wakil SJ. Studies on the mechanism of fatty acid synthesis. XVI. Preparation and general properties of acyl-malonyl acyl carrier protein-condensing enzyme from Escherichia coli. J Biol Chem. 1966 Mar 10; 241(5):1159-65. PMID: 5327099.
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    128. Pugh EL, Wakil SJ. Studies on the mechanism of fatty acid synthesis. XIV. The prosthetic group of acyl carrier protein and the mode of its attachment to the protein. J Biol Chem. 1965 Dec; 240(12):4727-33. PMID: 5321311.
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    129. SAUER F, PUGH EL, WAKIL SJ, DELANEY R, HILL RL. 2-MERCAPTOETHYLAMINE AND BETA-ALANINE AS COMPONENTS OF ACYL CARRIER PROTEIN. Proc Natl Acad Sci U S A. 1964 Dec; 52:1360-6. PMID: 14243509; PMCID: PMC300453.
    130. HOLLOWAY PW, WAKIL SJ. SYNTHESIS OF FATTY ACIDS IN ANIMAL TISSUES. II. THE OCCURRENCE AND BIOSYNTHESIS OF CIS-VACCENIC ACID. J Biol Chem. 1964 Aug; 239:2489-95. PMID: 14235526.
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    131. WAKIL SJ, PUGH EL, SAUER F. THE MECHANISM OF FATTY ACID SYNTHESIS. Proc Natl Acad Sci U S A. 1964 Jul; 52:106-14. PMID: 14192647; PMCID: PMC300581.
    132. HARLAN WR, WAKIL SJ. SYNTHESIS OF FATTY ACIDS IN ANIMAL TISSUES. I. INCORPORATION OF C14-ACETYL COENZYME A INTO A VARIETY OF LONG CHAIN FATTY ACIDS BY SUBCELLULAR PARTICLES. J Biol Chem. 1963 Oct; 238:3216-23. PMID: 14085364.
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    133. HOLLOWAY PW, PELUFFO R, WAKIL SJ. ON THE BIOSYNTHESIS OF DIENOIC FATTY ACID BY ANIMAL TISSUES. Biochem Biophys Res Commun. 1963 Aug 1; 12:300-4. PMID: 14070333.
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    134. WAITE M, WAKIL SJ. Studies on the mechanism of action of acetyl coenzyme A carboxylase. II. On the mechanism of action of enzyme-bound biotin. J Biol Chem. 1963 Jan; 238:81-90. PMID: 13998336.
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    135. WAITE M, WAKIL SJ. Studies on the mechanism of action of acetyl coenzyme A carboxylase. I. Effect of isocitrate on the transcarboxylation step of acetyl coenzyme A carboxylase. J Biol Chem. 1963 Jan; 238:77-80. PMID: 13998335.
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    136. WAITE M, WAKIL SJ. Studies on the mechanism of fatty acid synthesis. XII. Acetyl coenzyme A carboxylase. J Biol Chem. 1962 Sep; 237:2750-7. PMID: 14004432.
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    137. WAKIL SJ, BRESSLER R. Fatty acid metabolism and ketone body formation. Metabolism. 1962 Aug; 11:742-61. PMID: 14004467.
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    138. BRESSLER R, WAKIL SJ. Studies on the mechanism of fatty acid synthesis. XI. The product of the reaction and the role of sulfhydryl groups in the synthesis of fatty acids. J Biol Chem. 1962 May; 237:1441-8. PMID: 13872874.
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    139. WAKIL S, BRESSLER R. Studies on the mechanism of fatty acid synthesis. X. Reduced triphosphopyridine nucleotide-acetoacetyl coenzyme A reductase. J Biol Chem. 1962 Mar; 237:687-93. PMID: 14004466.
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    140. GIBSON DM, TITCHENER EB, WAKIL SJ. Studies on the mechanism of fatty acid synthesis. V. Bicarbonate requirement for the synthesis of long-chain fatty acids. Biochim Biophys Acta. 1958 Nov; 30(2):376-83. PMID: 13607455.
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    141. PORTER JW, WAKIL SJ, TIETZ A, JACOB MI, GIBSON DM. Studies on the mechanism of fatty acid synthesis. II. Cofactor requirements of the soluble pigeon liver system. Biochim Biophys Acta. 1957 Jul; 25(1):35-41. PMID: 13445712.
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    142. WAKIL SJ, PORTER JW, GIBSON DM. Studies on the mechanism of fatty acid synthesis. I. Preparation and purification of an enzymes system for reconstruction of fatty acid synthesis. Biochim Biophys Acta. 1957 Jun; 24(3):453-61. PMID: 13436465.
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    143. WAKIL SJ. Studies on the fatty acid oxidizing system of animal tissues. IX. Stereospecificity of unsaturated acyl CoA hydrase. Biochim Biophys Acta. 1956 Mar; 19(3):497-504. PMID: 13315310.
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    144. WAKIL SJ, GREEN DE, MII S, MAHLER HR. Studies on the fatty acid oxidizing system of animal tissues. VI. beta-Hydroxyacyl coenzyme A dehydrogenase. J Biol Chem. 1954 Apr; 207(2):631-8. PMID: 13163047.
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    145. WAKIL SJ, MAHLER HR. Studies on the fatty acid oxidizing system of animal tissues. V. Unsaturated fatty acyl coenzyme A hydrase. J Biol Chem. 1954 Mar; 207(1):125-32. PMID: 13152086.
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    146. MAHLER HR, WAKIL SJ, BOCK RM. Studies on fatty acid oxidation. I. Enzymatic activation of fatty acids. J Biol Chem. 1953 Sep; 204(1):453-68. PMID: 13084616.
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    147. HANAHAN DJ, WAKIL SJ. Studies on absorption and metabolism of ergosterol-C. Arch Biochem Biophys. 1953 May; 44(1):150-8. PMID: 13058363.
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