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WILLIAM T SHEARER

TitleDistinguished Service Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Allergy & Immunology
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleDistinguished Service Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionImmunology


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    1960Magna cum Laude Baccalaureate Honors, University of Detroit
    1960Senior Undergraduate Award in Biochemistry, University of Detroit
    1964Phi Lambda Upsilon (National Honorary Chemical Society), University of Detroit
    1965 - 1966Detroit New Pre-doctoral Fellowship Award, Wayne State University
    1966The Society of Sigma Xi
    1970St. Louis Pediatric Society Award
    1970Alexander Berg Award in Bacteriology
    1972 - 1974United States Public Health Service Special Research Fellowship Award
    1974 - 1977Research Scholar Award, Cystic Fibrosis Foundation
    1975Certificate of Merit, American Cancer Society, St. Louis City and County Unit
    1977 - 1979Faculty Research Award, American Cancer Society
    1981Elected to membership, American Society for Clinical Investigation
    1984Distinguished Teacher Award, Microbiology/Immunology, Baylor College of Medicine
    1985Myrtle Wreath Award, Hadassah
    1993Invited Speaker, The Child is the Future of Society: Pediatric AIDS, VIII Vatican International Conference
    1994Special Recognition Award, American Academy of Allergy, Asthma and Immunology
    2001Appreciation Award, Pediatric AIDS Clinical Trials Group
    2003Houston Regional Cabinet Award, Washington University, St. Louis
    2004Special Recognition Award, American Academy of Allergy, Asthma, and Immunology
    2004Distinguished Alumni Award, Washington University, St. Louis
    2005Arnold J. Rudolph Baylor Pediatric Award for Lifetime Excellence in Teaching, Baylor College of Medicine
    2006Elected, Editorial Advisory Board, Journal of Infectious Diseases
    2006William E. Pierson III, MD, Visiting Professorship, American Academy of Allergy, Asthma, & Immunol, Children's Hospital Univ.Washington Med Ctr Seattle
    2007 - 2008Marquis Who's Who in American Education 8th Ed 2008
    2007 - 2012Member, National Advisory Council, Washington University School of Medicine, St. Louis
    2007LeBien Visitng Professorship, Immune Deficiency Foundation, Tufts Baystate Univ Shcool of Medicine, Springfield, MA
    2008 - 2012Ethan A.H. Shepley Trustee, Washington Universty Board of Trustees, St. Louis
    2008Faculty member within Faculty of 1000 Medicine, Medicine Reports Limited, London, UK
    2008Elected, Association of American Physicians
    2009LeBien Visiting Professorship, Immune Deficiency Foundation, Tulane University School of Medicine, New Orleans, LA
    2009Recipient, Distinguished Service Award, Washington University School of Medicine, St. Louis
    2010Elected, Alpha Omega Alpha, Washington University Chapter
    2012Member, National School of Tropical Medicine
    2015Lagniappe Award, Pediatric HIV/AIDS Cohort Study, Bethesda, MD
    2003 - 2015Associate Editor, Journal of Allergy and Clinical Immunology
    2015Recipient, Distinguished Service Professor, Texas Children's Hospital/Baylor College of Medicine
    2015Boyle Scientific Achievement Award, Immune Deficiency Foundation, New Orleans, LA
    2017Recipient, Distinguished Service Award, Clinical Immunology Society

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li E, Grimes AB, Rider NL, Mahoney DH, Fleisher TA, Shearer WT. Diagnostic dilemma: ALPS versus Evans syndrome. Clin Immunol. 2017 Aug 09. PMID: 28802957.
      View in: PubMed
    2. Mahapatra S, Mace EM, Minard CG, Forbes LR, Vargas-Hernandez A, Duryea TK, Makedonas G, Banerjee PP, Shearer WT, Orange JS. High-resolution phenotyping identifies NK cell subsets that distinguish healthy children from adults. PLoS One. 2017; 12(8):e0181134. PMID: 28767726.
      View in: PubMed
    3. Shearer WT, Jacobson DL, Yu W, Siberry GK, Purswani M, Siminski S, Butler L, Leister E, Scott G, Van Dyke RB, Yogev R, Paul ME, Puga A, Colin AA, Kattan M. Long-Term Pulmonary Complications in Perinatally HIV-Infected Youth. J Allergy Clin Immunol. 2017 Mar 06. PMID: 28279683.
      View in: PubMed
    4. Huo Y, Patel K, Scott GB, Van Dyke RB, Siberry GK, Burchett SK, Shearer WT. Lymphocyte Subsets in HIV-Exposed Uninfected Infants and HIV-Unexposed Uninfected Infants. J Allergy Clin Immunol. 2017 Mar 06. PMID: 28279682.
      View in: PubMed
    5. Chinen J, Notarangelo LD, Shearer WT. Advances in clinical immunology in 2015. J Allergy Clin Immunol. 2016 Dec; 138(6):1531-1540. PMID: 27931534.
      View in: PubMed
    6. Stray-Pedersen A, Sorte HS, Samarakoon P, Gambin T, Chinn IK, Coban Akdemir ZH, Erichsen HC, Forbes LR, Gu S, Yuan B, Jhangiani SN, Muzny DM, Rødningen OK, Sheng Y, Nicholas SK, Noroski LM, Seeborg FO, Davis CM, Canter DL, Mace EM, Vece TJ, Allen CE, Abhyankar HA, Boone PM, Beck CR, Wiszniewski W, Fevang B, Aukrust P, Tjønnfjord GE, Gedde-Dahl T, Hjorth-Hansen H, Dybedal I, Nordøy I, Jørgensen SF, Abrahamsen TG, Øverland T, Bechensteen AG, Skogen V, Osnes LT, Kulseth MA, Prescott TE, Rustad CF, Heimdal KR, Belmont JW, Rider NL, Chinen J, Cao TN, Smith EA, Caldirola MS, Bezrodnik L, Lugo Reyes SO, Espinosa Rosales FJ, Guerrero-Cursaru ND, Pedroza LA, Poli CM, Franco JL, Trujillo Vargas CM, Aldave Becerra JC, Wright N, Issekutz TB, Issekutz AC, Abbott J, Caldwell JW, Bayer DK, Chan AY, Aiuti A, Cancrini C, Holmberg E, West C, Burstedt M, Karaca E, Yesil G, Artac H, Bayram Y, Atik MM, Eldomery MK, Ehlayel MS, Jolles S, Flatø B, Bertuch AA, Hanson IC, Zhang VW, Wong LJ, Hu J, Walkiewicz M, Yang Y, Eng CM, Boerwinkle E, Gibbs RA, Shearer WT, Lyle R, Orange JS, Lupski JR. Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders. J Allergy Clin Immunol. 2017 Jan; 139(1):232-245. PMID: 27577878.
      View in: PubMed
    7. Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Shearer WT, Burroughs LM, Torgerson TR, Decaluwe H, Haddad E. Primary Immune Deficiency Treatment Consortium (PIDTC) update. J Allergy Clin Immunol. 2016 Apr 22. PMID: 27262745.
      View in: PubMed
    8. Van Dyke RB, Patel K, Kagan RM, Karalius B, Traite S, Meyer WA, Tassiopoulos KK, Seage GR, Seybolt LM, Burchett S, Hazra R. Antiretroviral Drug Resistance Among Children and Youth in the United States With Perinatal HIV. Clin Infect Dis. 2016 Jul 01; 63(1):133-137. PMID: 27056398; PMCID: PMC4901868 [Available on 07/01/17].
    9. Chinn IK, Shearer WT. Severe Combined Immunodeficiency Disorders. Immunol Allergy Clin North Am. 2015 Nov; 35(4):671-94. PMID: 26454313.
      View in: PubMed
    10. Purswani MU, Karalius B, Yao TJ, Schmid DS, Burchett SK, Siberry GK, Patel K, Van Dyke RB, Yogev R. Prevalence and Persistence of Varicella Antibodies in Previously Immunized Children and Youth With Perinatal HIV-1 Infection. Clin Infect Dis. 2016 Jan 01; 62(1):106-114. PMID: 26385992.
      View in: PubMed
    11. Bonilla FA, Khan DA, Ballas ZK, Chinen J, Frank MM, Hsu JT, Keller M, Kobrynski LJ, Komarow HD, Mazer B, Nelson RP, Orange JS, Routes JM, Shearer WT, Sorensen RU, Verbsky JW, Bernstein DI, Blessing-Moore J, Lang D, Nicklas RA, Oppenheimer J, Portnoy JM, Randolph CR, Schuller D, Spector SL, Tilles S, Wallace D. Practice parameter for the diagnosis and management of primary immunodeficiency. J Allergy Clin Immunol. 2015 Nov; 136(5):1186-205.e1-78. PMID: 26371839.
      View in: PubMed
    12. Chinen J, Notarangelo LD, Shearer WT. Advances in basic and clinical immunology in 2014. J Allergy Clin Immunol. 2015 May; 135(5):1132-41. PMID: 25956014.
      View in: PubMed
    13. Zheng P, Noroski LM, Hanson IC, Chen Y, Lee ME, Huang Y, Zhu MX, Banerjee PP, Makedonas G, Orange JS, Shearer WT, Liu D. Molecular mechanisms of functional natural killer deficiency in patients with partial DiGeorge syndrome. J Allergy Clin Immunol. 2015 May; 135(5):1293-302. PMID: 25748067.
      View in: PubMed
    14. Lipshultz SE, Williams PL, Zeldow B, Wilkinson JD, Rich KC, van Dyke RB, Seage GR, Dooley LB, Kaltman JR, Siberry GK, Mofenson LM, Shearer WT, Colan SD. Cardiac effects of in-utero exposure to antiretroviral therapy in HIV-uninfected children born to HIV-infected mothers. AIDS. 2015 Jan 2; 29(1):91-100. PMID: 25562493; PMCID: PMC4287991.
    15. Bunupuradah T, Hansudewechakul R, Kosalaraksa P, Ngampiyaskul C, Kanjanavanit S, Wongsawat J, Luesomboon W, Sophonphan J, Puthanakit T, Ruxrungtham K, Shearer WT, Ananworanich J. HLA-DRB1454 and predictors of new-onset asthma in HIV-infected Thai children. Clin Immunol. 2015 Mar; 157(1):26-9. PMID: 25546395.
      View in: PubMed
    16. Mandala WL, Ananworanich J, Apornpong T, Kerr SJ, MacLennan JM, Hanson C, Jaimulwong T, Gondwe EN, Rosenblatt HM, Bunupuradah T, Molyneux ME, Spector SA, Pancharoen C, Gelman RS, MacLennan CA, Shearer WT. Control lymphocyte subsets: can one country's values serve for another's? J Allergy Clin Immunol. 2014 Sep; 134(3):759-761.e8. PMID: 25171870; PMCID: PMC4150016.
    17. Kwan A, Abraham RS, Currier R, Brower A, Andruszewski K, Abbott JK, Baker M, Ballow M, Bartoshesky LE, Bonilla FA, Brokopp C, Brooks E, Caggana M, Celestin J, Church JA, Comeau AM, Connelly JA, Cowan MJ, Cunningham-Rundles C, Dasu T, Dave N, De La Morena MT, Duffner U, Fong CT, Forbes L, Freedenberg D, Gelfand EW, Hale JE, Hanson IC, Hay BN, Hu D, Infante A, Johnson D, Kapoor N, Kay DM, Kohn DB, Lee R, Lehman H, Lin Z, Lorey F, Abdel-Mageed A, Manning A, McGhee S, Moore TB, Naides SJ, Notarangelo LD, Orange JS, Pai SY, Porteus M, Rodriguez R, Romberg N, Routes J, Ruehle M, Rubenstein A, Saavedra-Matiz CA, Scott G, Scott PM, Secord E, Seroogy C, Shearer WT, Siegel S, Silvers SK, Stiehm ER, Sugerman RW, Sullivan JL, Tanksley S, Tierce ML, Verbsky J, Vogel B, Walker R, Walkovich K, Walter JE, Wasserman RL, Watson MS, Weinberg GA, Weiner LB, Wood H, Yates AB, Puck JM, Bonagura VR. Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States. JAMA. 2014 Aug 20; 312(7):729-38. PMID: 25138334; PMCID: PMC4492158.
    18. Pai SY, Logan BR, Griffith LM, Buckley RH, Parrott RE, Dvorak CC, Kapoor N, Hanson IC, Filipovich AH, Jyonouchi S, Sullivan KE, Small TN, Burroughs L, Skoda-Smith S, Haight AE, Grizzle A, Pulsipher MA, Chan KW, Fuleihan RL, Haddad E, Loechelt B, Aquino VM, Gillio A, Davis J, Knutsen A, Smith AR, Moore TB, Schroeder ML, Goldman FD, Connelly JA, Porteus MH, Xiang Q, Shearer WT, Fleisher TA, Kohn DB, Puck JM, Notarangelo LD, Cowan MJ, O'Reilly RJ. Transplantation outcomes for severe combined immunodeficiency, 2000-2009. N Engl J Med. 2014 Jul 31; 371(5):434-46. PMID: 25075835; PMCID: PMC4183064.
    19. Shearer WT. Cure of HIV infection: is the long wait over? J Allergy Clin Immunol. 2014 Jul; 134(1):20-2. PMID: 25117800.
      View in: PubMed
    20. Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts. J Allergy Clin Immunol. 2014 Apr; 133(4):961-6. PMID: 24582311; PMCID: PMC4009347.
    21. Chinen J, Notarangelo LD, Shearer WT. Advances in basic and clinical immunology in 2013. J Allergy Clin Immunol. 2014 Apr; 133(4):967-76. PMID: 24589342; PMCID: PMC3988899.
    22. Ananworanich J, Bunupuradah T, Apornpong T, Kosalaraksa P, Hansudewechakul R, Kanjanavanit S, Ngampiyaskul C, Wongsawat J, Luesomboon W, Ngo-Giang-Huong N, Jaimulwong T, Kerr SJ, Brouwers P, Shearer WT, Puthanakit T. Association between lymphocyte and monocyte subsets and cognition in children with HIV. AIDS Res Ther. 2014; 11(1):7. PMID: 24450991; PMCID: PMC3900937.
    23. Patel K, Wang J, Jacobson DL, Lipshultz SE, Landy DC, Geffner ME, Dimeglio LA, Seage GR, Williams PL, Van Dyke RB, Siberry GK, Shearer WT, Young L, Scott GB, Wilkinson JD, Fisher SD, Starc TJ, Miller TL. Aggregate risk of cardiovascular disease among adolescents perinatally infected with the human immunodeficiency virus. Circulation. 2014 Mar 18; 129(11):1204-12. PMID: 24366631; PMCID: PMC3991841.
    24. Shearer WT, Dunn E, Notarangelo LD, Dvorak CC, Puck JM, Logan BR, Griffith LM, Kohn DB, O'Reilly RJ, Fleisher TA, Pai SY, Martinez CA, Buckley RH, Cowan MJ. Establishing diagnostic criteria for severe combined immunodeficiency disease (SCID), leaky SCID, and Omenn syndrome: the Primary Immune Deficiency Treatment Consortium experience. J Allergy Clin Immunol. 2014 Apr; 133(4):1092-8. PMID: 24290292; PMCID: PMC3972266.
    25. Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Pai SY, Ballard B, Bauer SC, Bleesing JJ, Boyle M, Brower A, Buckley RH, van der Burg M, Burroughs LM, Candotti F, Cant AJ, Chatila T, Cunningham-Rundles C, Dinauer MC, Dvorak CC, Filipovich AH, Fleisher TA, Bobby Gaspar H, Gungor T, Haddad E, Hovermale E, Huang F, Hurley A, Hurley M, Iyengar S, Kang EM, Logan BR, Long-Boyle JR, Malech HL, McGhee SA, Modell F, Modell V, Ochs HD, O'Reilly RJ, Parkman R, Rawlings DJ, Routes JM, Shearer WT, Small TN, Smith H, Sullivan KE, Szabolcs P, Thrasher A, Torgerson TR, Veys P, Weinberg K, Zuniga-Pflucker JC. Primary Immune Deficiency Treatment Consortium (PIDTC) report. J Allergy Clin Immunol. 2014 Feb; 133(2):335-47. PMID: 24139498; PMCID: PMC3960312.
    26. Dvorak CC, Cowan MJ, Logan BR, Notarangelo LD, Griffith LM, Puck JM, Kohn DB, Shearer WT, O'Reilly RJ, Fleisher TA, Pai SY, Hanson IC, Pulsipher MA, Fuleihan R, Filipovich A, Goldman F, Kapoor N, Small T, Smith A, Chan KW, Cuvelier G, Heimall J, Knutsen A, Loechelt B, Moore T, Buckley RH. The natural history of children with severe combined immunodeficiency: baseline features of the first fifty patients of the primary immune deficiency treatment consortium prospective study 6901. J Clin Immunol. 2013 Oct; 33(7):1156-64. PMID: 23818196; PMCID: PMC3784642.
    27. Lipshultz SE, Williams PL, Wilkinson JD, Leister EC, Van Dyke RB, Shearer WT, Rich KC, Hazra R, Kaltman JR, Jacobson DL, Dooley LB, Scott GB, Rabideau N, Colan SD. Cardiac status of children infected with human immunodeficiency virus who are receiving long-term combination antiretroviral therapy: results from the Adolescent Master Protocol of the Multicenter Pediatric HIV/AIDS Cohort Study. JAMA Pediatr. 2013 Jun; 167(6):520-7. PMID: 23608879; PMCID: PMC4180681.
    28. Wilkinson JD, Williams PL, Leister E, Zeldow B, Shearer WT, Colan SD, Siberry GK, Dooley LB, Scott GB, Rich KC, Lipshultz SE. Cardiac biomarkers in HIV-exposed uninfected children. AIDS. 2013 Apr 24; 27(7):1099-108. PMID: 23211773; PMCID: PMC4142694.
    29. Gelfand EW, Ochs HD, Shearer WT. Controversies in IgG replacement therapy in patients with antibody deficiency diseases. J Allergy Clin Immunol. 2013 Apr; 131(4):1001-5. PMID: 23540617.
      View in: PubMed
    30. Chinen J, Notarangelo LD, Shearer WT. Advances in basic and clinical immunology in 2012. J Allergy Clin Immunol. 2013 Mar; 131(3):675-82. PMID: 23374612.
      View in: PubMed
    31. Leechawengwongs E, Tison BE, Gopalakrishna GS, Reid BS, Bacino CA, Haws AL, Finegold MJ, Shearer WT. Does short bowel syndrome increase the risk of food allergy and eosinophilic gastrointestinal disease? Observations in Shah-Waardenburg syndrome. J Allergy Clin Immunol. 2013 Jan; 131(1):251-5. PMID: 23177999.
      View in: PubMed
    32. Puthanakit T, Saphonn V, Ananworanich J, Kosalaraksa P, Hansudewechakul R, Vibol U, Kerr SJ, Kanjanavanit S, Ngampiyaskul C, Wongsawat J, Luesomboon W, Ngo-Giang-Huong N, Chettra K, Cheunyam T, Suwarnlerk T, Ubolyam S, Shearer WT, Paul R, Mofenson LM, Fox L, Law MG, Cooper DA, Phanuphak P, Vun MC, Ruxrungtham K. Early versus deferred antiretroviral therapy for children older than 1 year infected with HIV (PREDICT): a multicentre, randomised, open-label trial. Lancet Infect Dis. 2012 Dec; 12(12):933-41. PMID: 23059199; PMCID: PMC3541427.
    33. De Golovine S, Wu S, Hunter JV, Shearer WT. Goldenhar syndrome: a cause of secondary immunodeficiency? Allergy Asthma Clin Immunol. 2012; 8(1):10. PMID: 22747588; PMCID: PMC3441207.
    34. Leechawengwongs E, Shearer WT. Lymphoma complicating primary immunodeficiency syndromes. Curr Opin Hematol. 2012 Jul; 19(4):305-12. PMID: 22525579.
      View in: PubMed
    35. Foster SB, Lu M, Glaze DG, Reuben JM, Harris LL, Cohen EN, Lee BN, Zhao E, Paul ME, Schwarzwald H, McMullen-Jackson C, Clark C, Armstrong FD, Brouwers PY, Miller TL, Colin AA, Scott GB, Shahzeidi S, Willen EJ, Asthana D, Lipshultz SE, Thompson BW, Shearer WT. Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection. Clin Immunol. 2012 Jul; 144(1):13-23. PMID: 22659030; PMCID: PMC3377781.
    36. Hanson IC, Shearer WT. Ruling out HIV infection when testing for severe combined immunodeficiency and other T-cell deficiencies. J Allergy Clin Immunol. 2012 Mar; 129(3):875-876.e5. PMID: 22386446.
      View in: PubMed
    37. Sitcharungsi R, Ananworanich J, Vilaiyuk S, Apornpong T, Bunupuradah T, Pornvoranunt A, Nouanthong P, Phasomsap C, Khupulsup K, Pancharoen C, Puthanakit T, Shearer WT, Benjaponpitak S. Nephelometry determined serum immunoglobulin isotypes in healthy Thai children aged 2-15 years. Microbiol Immunol. 2012 Feb; 56(2):117-22. PMID: 22181033.
      View in: PubMed
    38. Shearer WT, Corry DB. High prevalence of asthma in HIV-infected adults: new insights. J Allergy Clin Immunol. 2012 Mar; 129(3):715-6. PMID: 22296750; PMCID: PMC3294045.
    39. Shearer WT. Screening for severe combined immunodeficiency in newborns. J Allergy Clin Immunol. 2012 Mar; 129(3):619-21. PMID: 22277197.
      View in: PubMed
    40. Chinen J, Shearer WT. Advances in basic and clinical immunology in 2011. J Allergy Clin Immunol. 2012 Feb; 129(2):342-8. PMID: 22206779; PMCID: PMC3279946.
    41. Martinez CA, Shah S, Shearer WT, Rosenblatt HM, Paul ME, Chinen J, Leung KS, Kennedy-Nasser A, Brenner MK, Heslop HE, Liu H, Wu MF, Hanson IC, Krance RA. Excellent survival after sibling or unrelated donor stem cell transplantation for chronic granulomatous disease. J Allergy Clin Immunol. 2012 Jan; 129(1):176-83. PMID: 22078471.
      View in: PubMed
    42. Siberry GK, Leister E, Jacobson DL, Foster SB, Seage GR, Lipshultz SE, Paul ME, Purswani M, Colin AA, Scott G, Shearer WT. Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents. Clin Immunol. 2012 Feb; 142(2):201-8. PMID: 22094294; PMCID: PMC3273595.
    43. Tison BE, Nicholas SK, Abramson SL, Hanson IC, Paul ME, Seeborg FO, Shearer WT, Perez MD, Noroski LM, Chinen J. Autoimmunity in a cohort of 130 pediatric patients with partial DiGeorge syndrome. J Allergy Clin Immunol. 2011 Nov; 128(5):1115-7.e1-3. PMID: 21835443.
      View in: PubMed
    44. Marcus N, Takada H, Law J, Cowan MJ, Gil J, Regueiro JR, Plaza Lopez de Sabando D, Lopez-Granados E, Dalal J, Friedrich W, Manfred H, Hanson IC, Grunebaum E, Shearer WT, Roifman CM. Hematopoietic stem cell transplantation for CD3? deficiency. J Allergy Clin Immunol. 2011 Nov; 128(5):1050-7. PMID: 21757226; PMCID: PMC4490832.
    45. Nicholas S, Krance RA, Hanson IC, Chinen J, Mamlok RJ, Roifman CM, Shearer WT. Early versus delayed diagnosis of SCID: triumph versus tragedy. Clin Immunol. 2011 Jun; 139(3):360-2. PMID: 21497138.
      View in: PubMed
    46. Chinen J, Shearer WT. Advances in basic and clinical immunology in 2010. J Allergy Clin Immunol. 2011 Feb; 127(2):336-41. PMID: 21281863; PMCID: PMC3057129.
    47. Lipshultz SE, Shearer WT, Thompson B, Rich KC, Cheng I, Orav EJ, Kumar S, Pignatelli RH, Bezold LI, LaRussa P, Starc TJ, Glickstein JS, O'Brien S, Cooper ER, Wilkinson JD, Miller TL, Colan SD. Cardiac effects of antiretroviral therapy in HIV-negative infants born to HIV-positive mothers: NHLBI CHAART-1 (National Heart, Lung, and Blood Institute Cardiovascular Status of HAART Therapy in HIV-Exposed Infants and Children cohort study). J Am Coll Cardiol. 2011 Jan 4; 57(1):76-85. PMID: 21185505; PMCID: PMC3243620.
    48. Ananworanich J, Apornpong T, Kosalaraksa P, Jaimulwong T, Hansudewechakul R, Pancharoen C, Bunupuradah T, Chandara M, Puthanakit T, Ngampiyasakul C, Wongsawat J, Kanjanavanit S, Luesomboon W, Klangsinsirikul P, Ngo-Giang-Huong N, Kerr SJ, Ubolyam S, Mengthaisong T, Gelman RS, Pattanapanyasat K, Saphonn V, Ruxrungtham K, Shearer WT. Characteristics of lymphocyte subsets in HIV-infected, long-term nonprogressor, and healthy Asian children through 12 years of age. J Allergy Clin Immunol. 2010 Dec; 126(6):1294-301.e10. PMID: 21134574; PMCID: PMC3004741.
    49. Okocha IU, Hanson CG, Chinen J, Shearer WT. Decline of antibodies in XLA infant: when to start IVIG. Allergy. 2011 Mar; 66(3):434-5. PMID: 21284651; PMCID: PMC3408709.
    50. Foster SB, Lu M, Thompson B, Rich KC, Matukas LM, Mason R, Winchester R, MacDonald KS, Shearer WT. Association between HLA inheritance and asthma medication use in HIV positive children. AIDS. 2010 Aug 24; 24(13):2133-5. PMID: 20613458; PMCID: PMC3665405.
    51. Buist MD, Shearer W. Rapid response systems: a mandatory system of care or an optional extra for bedside clinical staff. Jt Comm J Qual Patient Saf. 2010 Jun; 36(6):263-5, 241. PMID: 20564887.
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    52. Discordance between CD4 cell count and CD4 cell percentage: implications for when to start antiretroviral therapy in HIV-1 infected children. AIDS. 2010 May 15; 24(8):1213-7. PMID: 20386428.
      View in: PubMed
    53. Chinen J, Shearer WT. Advances in basic and clinical immunology in 2009. J Allergy Clin Immunol. 2010 Mar; 125(3):563-8. PMID: 20226292; PMCID: PMC2841291.
    54. Shearer WT, Leung DY. Preface to the 2010 primer on allergic and immunologic diseases. J Allergy Clin Immunol. 2010 Feb; 125(2 Suppl 2):S1-2. PMID: 20176254.
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    55. Chinen J, Shearer WT. Secondary immunodeficiencies, including HIV infection. J Allergy Clin Immunol. 2010 Feb; 125(2 Suppl 2):S195-203. PMID: 20042227.
      View in: PubMed
    56. Shah SS, Bacino CA, Sheehan AM, Shearer WT. Diagnosis of primary immunodeficiency: let your eyes do the talking. J Allergy Clin Immunol. 2009 Dec; 124(6):1363-4.e1. PMID: 20004789.
      View in: PubMed
    57. Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH, Candotti F, Conley ME, Fleisher TA, Gaspar HB, Kohn DB, Ochs HD, O'Reilly RJ, Rizzo JD, Roifman CM, Small TN, Shearer WT. Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management. J Allergy Clin Immunol. 2009 Dec; 124(6):1152-60.e12. PMID: 20004776; PMCID: PMC2831471.
    58. Aldrovandi GM, Chu C, Shearer WT, Li D, Walter J, Thompson B, McIntosh K, Foca M, Meyer WA, Ha BF, Rich KC, Moye J. Antiretroviral exposure and lymphocyte mtDNA content among uninfected infants of HIV-1-infected women. Pediatrics. 2009 Dec; 124(6):e1189-97. PMID: 19933732; PMCID: PMC2904486.
    59. Patel NC, Chinen J, Rosenblatt HM, Hanson IC, Krance RA, Paul ME, Abramson SL, Noroski LM, Davis CM, Seeborg FO, Foster SB, Leung KS, Brown BS, Ritz J, Shearer WT. Outcomes of patients with severe combined immunodeficiency treated with hematopoietic stem cell transplantation with and without preconditioning. J Allergy Clin Immunol. 2009 Nov; 124(5):1062-9.e1-4. PMID: 19895994; PMCID: PMC3271026.
    60. Narra MB, Shearer WT. Cartilage-hair hypoplasia and severe allergy. J Allergy Clin Immunol. 2009 Jun; 123(6):1418-9; author reply 1419-20. PMID: 19394685.
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    61. Tantibhaedhyangkul U, Davis CM, Noroski LM, Hanson IC, Shearer WT, Chinen J. Role of IL-7 in the regulation of T-cell homeostasis in partial DiGeorge syndrome. J Allergy Clin Immunol. 2009 Apr; 123(4):960-2.e2. PMID: 19230961.
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    62. Shearer WT, Ochs HD, Lee BN, Cohen EN, Reuben JM, Cheng I, Thompson B, Butel JS, Blancher A, Abbal M, Aviles H, Sonnenfeld G. Immune responses in adult female volunteers during the bed-rest model of spaceflight: antibodies and cytokines. J Allergy Clin Immunol. 2009 Apr; 123(4):900-5. PMID: 19232702.
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    63. Chinen J, Shearer WT. Advances in basic and clinical immunology in 2008. J Allergy Clin Immunol. 2009 Feb; 123(2):328-32. PMID: 19203657.
      View in: PubMed
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    65. Nance CL, Siwak EB, Shearer WT. Preclinical development of the green tea catechin, epigallocatechin gallate, as an HIV-1 therapy. J Allergy Clin Immunol. 2009 Feb; 123(2):459-65. PMID: 19203663; PMCID: PMC2665796.
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    67. Patel NC, Chinen J, Rosenblatt HM, Hanson IC, Brown BS, Paul ME, Abramson SL, Ritz J, Shearer WT. Long-term outcomes of nonconditioned patients with severe combined immunodeficiency transplanted with HLA-identical or haploidentical bone marrow depleted of T cells with anti-CD6 mAb. J Allergy Clin Immunol. 2008 Dec; 122(6):1185-93. PMID: 19084111.
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    68. Weinberg A, Dickover R, Britto P, Hu C, Patterson-Bartlett J, Kraimer J, Gutzman H, Shearer WT, Rathore M, McKinney R. Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy. AIDS. 2008 Nov 12; 22(17):2267-77. PMID: 18981766; PMCID: PMC2748303.
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    72. Pahwa S, Read JS, Yin W, Matthews Y, Shearer W, Diaz C, Rich K, Mendez H, Thompson B. CD4+/CD8+ T cell ratio for diagnosis of HIV-1 infection in infants: Women and Infants Transmission Study. Pediatrics. 2008 Aug; 122(2):331-9. PMID: 18676551; PMCID: PMC4699439.
    73. Foster SB, McIntosh K, Thompson B, Lu M, Yin W, Rich KC, Mendez H, Serchuck LK, Diaz C, Paul ME, Shearer WT. Increased incidence of asthma in HIV-infected children treated with highly active antiretroviral therapy in the National Institutes of Health Women and Infants Transmission Study. J Allergy Clin Immunol. 2008 Jul; 122(1):159-65. PMID: 18547627; PMCID: PMC3246282.
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    76. Shearer WT. Breastfeeding and HIV infection. Pediatrics. 2008 May; 121(5):1046-7. PMID: 18450909.
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    77. Capparelli EV, Aweeka F, Hitti J, Stek A, Hu C, Burchett SK, Best B, Smith E, Read JS, Watts H, Nachman S, Thorpe EM, Spector SA, Jimenez E, Shearer WT, Foca M, Mirochnick M. Chronic administration of nevirapine during pregnancy: impact of pregnancy on pharmacokinetics. HIV Med. 2008 Apr; 9(4):214-20. PMID: 18366444; PMCID: PMC2755564.
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    79. Davis CM, Shearer WT. Diagnosis and management of HIV drug hypersensitivity. J Allergy Clin Immunol. 2008 Apr; 121(4):826-832.e5. PMID: 18190954.
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    80. Purevjav E, Nelson DP, Varela JJ, Jimenez S, Kearney DL, Sanchez XV, DeFreitas G, Carabello B, Taylor MD, Vatta M, Shearer WT, Towbin JA, Bowles NE. Myocardial Fas ligand expression increases susceptibility to AZT-induced cardiomyopathy. Cardiovasc Toxicol. 2007; 7(4):255-63. PMID: 17943461.
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    81. Shearer WT, Pahwa S, Read JS, Chen J, Wijayawardana SR, Palumbo P, Abrams EJ, Nesheim SR, Yin W, Thompson B, Easley KA. CD4/CD8 T-cell ratio predicts HIV infection in infants: the National Heart, Lung, and Blood Institute P2C2 Study. J Allergy Clin Immunol. 2007 Dec; 120(6):1449-56. PMID: 17920669; PMCID: PMC4271194.
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    83. Shearer WT, Malech HL, Puck JM. Primary immunodeficiency: meeting the challenges. J Allergy Clin Immunol. 2007 Oct; 120(4):753-5. PMID: 17931558.
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    86. Foster SB, Paul ME, Kozinetz CA, Macias CG, Shearer WT. Prevalence of asthma in children and young adults with HIV infection. J Allergy Clin Immunol. 2007 Mar; 119(3):750-2. PMID: 17336620.
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    87. Fletcher CV, DeVille JG, Samson PM, Moye JH, Church JA, Spiegel HM, Palumbo P, Fenton T, Smith ME, Graham B, Kraimer JM, Shearer WT. Nonlinear pharmacokinetics of high-dose recombinant fusion protein CD4-IgG2 (PRO 542) observed in HIV-1-infected children. J Allergy Clin Immunol. 2007 Mar; 119(3):747-50. PMID: 17336619; PMCID: PMC1910693.
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    89. Cord blood banking for potential future transplantation. Pediatrics. 2007 Jan; 119(1):165-70. PMID: 17200285.
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    90. Williamson MP, McCormick TG, Nance CL, Shearer WT. Epigallocatechin gallate, the main polyphenol in green tea, binds to the T-cell receptor, CD4: Potential for HIV-1 therapy. J Allergy Clin Immunol. 2006 Dec; 118(6):1369-74. PMID: 17157668.
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    91. Pacheco SE, McIntosh K, Lu M, Mofenson LM, Diaz C, Foca M, Frederick M, Handelsman E, Hayani K, Shearer WT. Effect of perinatal antiretroviral drug exposure on hematologic values in HIV-uninfected children: An analysis of the women and infants transmission study. J Infect Dis. 2006 Oct 15; 194(8):1089-97. PMID: 16991083.
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    92. Lee BN, Follen M, Rodriquez G, Shen DY, Malpica A, Shearer WT, Reuben JM. Deficiencies in myeloid antigen-presenting cells in women with cervical squamous intraepithelial lesions. Cancer. 2006 Sep 1; 107(5):999-1007. PMID: 16874820.
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    93. Chinen J, Finkelman F, Shearer WT. Advances in basic and clinical immunology. J Allergy Clin Immunol. 2006 Aug; 118(2):489-95. PMID: 16890776.
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    94. Shearer WT, DeVille JG, Samson PM, Moye JH, Fletcher CV, Church JA, Spiegel HM, Palumbo P, Fenton T, Smith ME, Graham B, Kraimer JM, Olson WC. Susceptibility of pediatric HIV-1 isolates to recombinant CD4-IgG2 (PRO 542) and humanized mAb to the chemokine receptor CCR5 (PRO 140). J Allergy Clin Immunol. 2006 Aug; 118(2):518-21. PMID: 16890780.
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    95. Macias CG, Caviness AC, Sockrider M, Brooks E, Kronfol R, Bartholomew LK, Abramson S, Shearer W. The effect of acute and chronic asthma severity on pediatric emergency department utilization. Pediatrics. 2006 Apr; 117(4 Pt 2):S86-95. PMID: 16777836.
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    96. Shearer WT, Fischer A. The last 80 years in primary immunodeficiency: how far have we come, how far need we go? J Allergy Clin Immunol. 2006 Apr; 117(4):748-52. PMID: 16630928.
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    97. Shearer WT, Leung DY. Preface to the 2006 Mini-Primer on Allergic and Immunologic Diseases. J Allergy Clin Immunol. 2006 Feb; 117(2 Suppl Mini-Primer):S429. PMID: 16455340.
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    98. Seeborg FO, Gay H, Schmiege LM, Bernard D, Shearer WT. Immunoglobulin G kappa [IgG kappa] and IgG lambda paraproteinemia in a child with AIDS and response to highly active antiretroviral therapy. Clin Diagn Lab Immunol. 2005 Nov; 12(11):1331-3. PMID: 16275950; PMCID: PMC1287768.
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    100. Shearer WT. Infection versus immunity: What's the balance? J Allergy Clin Immunol. 2005 Aug; 116(2):263-6. PMID: 16083777.
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    101. Shearer WT, Zhang S, Reuben JM, Lee BN, Butel JS. Effects of radiation and latent virus on immune responses in a space flight model. J Allergy Clin Immunol. 2005 Jun; 115(6):1297-303. PMID: 15940150.
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    102. Haining WN, Neuberg DS, Keczkemethy HL, Evans JW, Rivoli S, Gelman R, Rosenblatt HM, Shearer WT, Guenaga J, Douek DC, Silverman LB, Sallan SE, Guinan EC, Nadler LM. Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia. Blood. 2005 Sep 1; 106(5):1749-54. PMID: 15920008; PMCID: PMC1895221.
    103. Paul ME, Mao C, Charurat M, Serchuck L, Foca M, Hayani K, Handelsman EL, Diaz C, McIntosh K, Shearer WT. Predictors of immunologic long-term nonprogression in HIV-infected children: implications for initiating therapy. J Allergy Clin Immunol. 2005 Apr; 115(4):848-55. PMID: 15806009.
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    104. Chinen J, Shearer WT. Advances in asthma, allergy and immunology series 2004: basic and clinical immunology. J Allergy Clin Immunol. 2004 Aug; 114(2):398-405. PMID: 15316523.
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    105. Shearer WT. Importance of technology for the future of allergy and immunology. J Allergy Clin Immunol. 2004 Aug; 114(2):406-8. PMID: 15316524.
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    106. Moylett EH, Wasan AN, Noroski LM, Shearer WT. Live viral vaccines in patients with partial DiGeorge syndrome: clinical experience and cellular immunity. Clin Immunol. 2004 Jul; 112(1):106-12. PMID: 15207787.
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    107. Winchester R, Pitt J, Charurat M, Magder LS, Göring HH, Landay A, Read JS, Shearer W, Handelsman E, Luzuriaga K, Hillyer GV, Blattner W. Mother-to-child transmission of HIV-1: strong association with certain maternal HLA-B alleles independent of viral load implicates innate immune mechanisms. J Acquir Immune Defic Syndr. 2004 Jun 1; 36(2):659-70. PMID: 15167284.
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    108. Seeborg FO, Paul ME, Abramson SL, Kearney DL, Dorfman SR, Holland SM, Shearer WT. A 5-week-old HIV-1-exposed girl with failure to thrive and diffuse nodular pulmonary infiltrates. J Allergy Clin Immunol. 2004 Apr; 113(4):627-34. PMID: 15100665.
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    109. Shearer WT, Cunningham-Rundles C, Ochs HD. Primary immunodeficiency: looking backwards, looking forwards. J Allergy Clin Immunol. 2004 Apr; 113(4):607-9. PMID: 15100662.
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    110. Lee BN, Follen M, Shen DY, Malpica A, Adler-Storthz K, Shearer WT, Reuben JM. Depressed type 1 cytokine synthesis by superantigen-activated CD4+ T cells of women with human papillomavirus-related high-grade squamous intraepithelial lesions. Clin Diagn Lab Immunol. 2004 Mar; 11(2):239-44. PMID: 15013969; PMCID: PMC371191.
    111. Lavigne JE, Shearer WT, Thompson B, Orav EJ, Starc TJ, Colan SD, Pignatelli R, O'Brien SE, Bezold L, LaRusa P, Easley KA, Cheng I, Duffy SA, Lipshultz SE. Cardiovascular outcomes of pediatric seroreverters perinatally exposed to HAART: design of a longitudinal clinical study. Cardiovasc Toxicol. 2004; 4(2):187-97. PMID: 15371634.
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    112. Shearer WT, Rosenblatt HM, Gelman RS, Oyomopito R, Plaeger S, Stiehm ER, Wara DW, Douglas SD, Luzuriaga K, McFarland EJ, Yogev R, Rathore MH, Levy W, Graham BL, Spector SA. Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study. J Allergy Clin Immunol. 2003 Nov; 112(5):973-80. PMID: 14610491.
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    113. Nance CL, Shearer WT. Is green tea good for HIV-1 infection? J Allergy Clin Immunol. 2003 Nov; 112(5):851-3. PMID: 14610469.
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    114. Nachman S, Kim S, King J, Abrams EJ, Margolis D, Petru A, Shearer W, Smith E, Moye J, Blanchard S, Hawkins E, Bouquin P, Vink P, Benson M, Estep S, Malinoski F. Safety and immunogenicity of a heptavalent pneumococcal conjugate vaccine in infants with human immunodeficiency virus type 1 infection. Pediatrics. 2003 Jul; 112(1 Pt 1):66-73. PMID: 12837869.
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    115. Moylett EH, Chinen J, Shearer WT. Trichosporon pullulans infection in 2 patients with chronic granulomatous disease: an emerging pathogen and review of the literature. J Allergy Clin Immunol. 2003 Jun; 111(6):1370-4. PMID: 12789241.
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    116. Chinen J, Rosenblatt HM, Smith EO, Shearer WT, Noroski LM. Long-term assessment of T-cell populations in DiGeorge syndrome. J Allergy Clin Immunol. 2003 Mar; 111(3):573-9. PMID: 12642839.
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    117. Chinen J, Shearer WT. Basic and clinical immunology. J Allergy Clin Immunol. 2003 Mar; 111(3 Suppl):S813-8. PMID: 12618748.
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    118. Shearer WT, Fathman CG. 30. Defining the spectrum of clinical immunology. J Allergy Clin Immunol. 2003 Feb; 111(2 Suppl):S766-73. PMID: 12592321.
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    119. Sonnenfeld G, Butel JS, Shearer WT. Effects of the space flight environment on the immune system. Rev Environ Health. 2003 Jan-Mar; 18(1):1-17. PMID: 12875508.
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    120. Nance CL, Shearer WT. SDF-1alpha regulates HIV-1-gp120-induced changes in CD79b surface expression and Ig production in activated human B cells. Clin Immunol. 2002 Nov; 105(2):208-14. PMID: 12482395.
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    121. Sonnenfeld G, Shearer WT. Immune function during space flight. Nutrition. 2002 Oct; 18(10):899-903. PMID: 12361785.
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    122. Shearer WT. Recognition of clinical immunology as a distinct medical subspecialty: importance for the practice of allergy. J Allergy Clin Immunol. 2002 Oct; 110(4):567-70. PMID: 12373262.
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    123. Chinen J, Shearer WT. Molecular virology and immunology of HIV infection. J Allergy Clin Immunol. 2002 Aug; 110(2):189-98. PMID: 12170257.
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    124. Reuben JM, Lee BN, Paul M, Kline MW, Cron SG, Abramson S, Lewis D, Kozinetz CA, Shearer WT. Magnitude of IFN-gamma production in HIV-1-infected children is associated with virus suppression. J Allergy Clin Immunol. 2002 Aug; 110(2):255-61. PMID: 12170266.
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    125. Moylett EH, Shearer WT. HIV: clinical manifestations. J Allergy Clin Immunol. 2002 Jul; 110(1):3-16. PMID: 12110810.
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    126. Jenson HB, Gauntt CJ, Easley KA, Pitt J, Lipshultz SE, McIntosh K, Shearer WT. Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy. J Infect Dis. 2002 Jun 15; 185(12):1798-802. PMID: 12085328; PMCID: PMC4422982.
    127. Shearer WT, Lee BN, Cron SG, Rosenblatt HM, Smith EO, Lugg DJ, Nickolls PM, Sharp RM, Rollings K, Reuben JM. Suppression of human anti-inflammatory plasma cytokines IL-10 and IL-1RA with elevation of proinflammatory cytokine IFN-gamma during the isolation of the Antarctic winter. J Allergy Clin Immunol. 2002 May; 109(5):854-7. PMID: 11994711.
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    128. Miller TL, Easley KA, Zhang W, Orav EJ, Bier DM, Luder E, Ting A, Shearer WT, Vargas JH, Lipshultz SE. Maternal and infant factors associated with failure to thrive in children with vertically transmitted human immunodeficiency virus-1 infection: the prospective, P2C2 human immunodeficiency virus multicenter study. Pediatrics. 2001 Dec; 108(6):1287-96. PMID: 11731650; PMCID: PMC4383837.
    129. Chinen J, Easley KA, Mendez H, Shearer WT. Decline of CD3-positive T-cell counts by 6 months of age is associated with rapid disease progression in HIV-1--infected infants. J Allergy Clin Immunol. 2001 Aug; 108(2):265-8. PMID: 11496244; PMCID: PMC4357165.
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    131. Shearer WT. Consequences of contamination of the spacecraft environment: immunologic consequences. Gravit Space Biol Bull. 2001 Jun; 14(2):7-14. PMID: 11865871.
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    132. Shearer WT, Reuben JM, Mullington JM, Price NJ, Lee BN, Smith EO, Szuba MP, Van Dongen HP, Dinges DF. Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J Allergy Clin Immunol. 2001 Jan; 107(1):165-70. PMID: 11150007.
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    133. Lee BN, Hammill H, Popek EJ, Cron S, Kozinetz C, Paul M, Shearer WT, Reuben JM. Production of interferons and beta-chemokines by placental trophoblasts of HIV-1-infected women. Infect Dis Obstet Gynecol. 2001; 9(2):95-104. PMID: 11495560; PMCID: PMC1784647.
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    135. Shearer WT, Easley KA, Goldfarb J, Jenson HB, Rosenblatt HM, Kovacs A, McIntosh K. Evaluation of immune survival factors in pediatric HIV-1 infection. Ann N Y Acad Sci. 2000 Nov; 918:298-312. PMID: 11144332; PMCID: PMC4412260.
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    137. Shearer WT, Easley KA, Goldfarb J, Rosenblatt HM, Jenson HB, Kovacs A, McIntosh K. Prospective 5-year study of peripheral blood CD4, CD8, and CD19/CD20 lymphocytes and serum Igs in children born to HIV-1 women. The P(2)C(2) HIV Study Group. J Allergy Clin Immunol. 2000 Sep; 106(3):559-66. PMID: 10984378; PMCID: PMC4360071.
    138. Lambert JS, Watts DH, Mofenson L, Stiehm ER, Harris DR, Bethel J, Whitehouse J, Jimenez E, Gandia J, Scott G, O'Sullivan MJ, Kovacs A, Stek A, Shearer WT, Hammill H, van Dyke R, Maupin R, Silio M, Fowler MG. Risk factors for preterm birth, low birth weight, and intrauterine growth retardation in infants born to HIV-infected pregnant women receiving zidovudine. Pediatric AIDS Clinical Trials Group 185 Team. AIDS. 2000 Jul 7; 14(10):1389-99. PMID: 10930154.
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    139. Fahey JL, Aziz N, Spritzler J, Plaeger S, Nishanian P, Lathey JL, Seigel J, Landay AL, Kilarui R, Schmitz JL, White C, Wara DW, Akridge R, Cutili J, Douglas SD, Reuben J, Shearer WT, Nokta M, Polland R, Schooley R, Asthana D, Mizrachi Y, Waxdal M. Need for an external proficiency testing program for cytokines, chemokines, and plasma markers of immune activation. Clin Diagn Lab Immunol. 2000 Jul; 7(4):540-8. PMID: 10882648; PMCID: PMC95910.
    140. Patke CL, Shearer WT. gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. J Allergy Clin Immunol. 2000 May; 105(5):975-82. PMID: 10808179.
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    141. Cohen H, Chen XC, Sunkle S, Davis L, Geromanos K, Xanthos G, Shearer W. Ability of caregivers to read delayed hypersensitivity skin tests in children exposed to and infected by HIV. The Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Study Group. J Pediatr Health Care. 2000 Mar-Apr; 14(2):50-5. PMID: 10736138.
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    142. Stiehm ER, Fletcher CV, Mofenson LM, Palumbo PE, Kang M, Fenton T, Sapan CV, Meyer WA, Shearer WT, Hawkins E, Fowler MG, Bouquin P, Purdue L, Sloand EM, Nemo GJ, Wara D, Bryson YJ, Starr SE, Petru A, Burchett S. Use of human immunodeficiency virus (HIV) human hyperimmune immunoglobulin in HIV type 1-infected children (Pediatric AIDS clinical trials group protocol 273). J Infect Dis. 2000 Feb; 181(2):548-54. PMID: 10669338.
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    143. Shearer WT, Lipshultz SE, Easley KA, McIntosh K, Pitt J, Quinn TC, Kattan M, Goldfarb J, Cooper E, Bryson Y, Kovacs A, Bricker JT, Peavy H, Mellins RB, Heart N, Institute LB. Alterations in cardiac and pulmonary function in pediatric rapid human immunodeficiency virus type 1 disease progressors. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted Human Immunodeficiency Virus Study Group. Pediatrics. 2000 Jan; 105(1):e9. PMID: 10617746; PMCID: PMC4331103.
    144. Lee BN, Follen M, Tortolero-Luna G, Eriksen N, Helfgott A, Hammill H, Shearer WT, Reuben JM. Synthesis of IFN-gamma by CD8(+) T cells is preserved in HIV-infected women with HPV-related cervical squamous intraepithelial lesions. Gynecol Oncol. 1999 Dec; 75(3):379-86. PMID: 10600293.
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    145. Shearer WT, Abramson SL, Adelman DC, Corn B, Cunningham-Rundles C, Kishiyama JL, Richmond W, Shames RS, Sperber K, Stiehm ER, Valacer DJ. Letter to the editor regarding the use of intravenous immunoglobulin (IVIG) in asthma. Clin Immunol. 1999 Nov; 93(2):184-6. PMID: 10527695.
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    146. Kalish LA, McIntosh K, Read JS, Diaz C, Landesman SH, Pitt J, Rich KC, Shearer WT, Davenny K, Lew JF. Evaluation of human immunodeficiency virus (HIV) type 1 load, CD4 T cell level, and clinical class as time-fixed and time-varying markers of disease progression in HIV-1-infected children. J Infect Dis. 1999 Nov; 180(5):1514-20. PMID: 10515810.
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    147. Bowles NE, Kearney DL, Ni J, Perez-Atayde AR, Kline MW, Bricker JT, Ayres NA, Lipshultz SE, Shearer WT, Towbin JA. The detection of viral genomes by polymerase chain reaction in the myocardium of pediatric patients with advanced HIV disease. J Am Coll Cardiol. 1999 Sep; 34(3):857-65. PMID: 10483970.
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    148. Kovacs A, Schluchter M, Easley K, Demmler G, Shearer W, La Russa P, Pitt J, Cooper E, Goldfarb J, Hodes D, Kattan M, McIntosh K. Cytomegalovirus infection and HIV-1 disease progression in infants born to HIV-1-infected women. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group. N Engl J Med. 1999 Jul 8; 341(2):77-84. PMID: 10395631; PMCID: PMC4280563.
    149. Jenson H, McIntosh K, Pitt J, Husak S, Tan M, Bryson Y, Easley K, Shearer W. Natural history of primary Epstein-Barr virus infection in children of mothers infected with human immunodeficiency virus type 1. J Infect Dis. 1999 Jun; 179(6):1395-404. PMID: 10228060; PMCID: PMC4360073.
    150. Shearer WT, Kline MW, Abramson SL, Fenton T, Starr SE, Douglas SD. Recombinant human gamma interferon in human immunodeficiency virus-infected children: safety, CD4(+)-lymphocyte count, viral load, and neutrophil function (AIDS Clinical Trials Group Protocol 211). Clin Diagn Lab Immunol. 1999 May; 6(3):311-5. PMID: 10225828; PMCID: PMC103715.
    151. Kishiyama JL, Valacer D, Cunningham-Rundles C, Sperber K, Richmond GW, Abramson S, Glovsky M, Stiehm R, Stocks J, Rosenberg L, Shames RS, Corn B, Shearer WT, Bacot B, DiMaio M, Tonetta S, Adelman DC. A multicenter, randomized, double-blind, placebo-controlled trial of high-dose intravenous immunoglobulin for oral corticosteroid-dependent asthma. Clin Immunol. 1999 May; 91(2):126-33. PMID: 10227804.
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    152. Stiehm ER, Lambert JS, Mofenson LM, Bethel J, Whitehouse J, Nugent R, Moye J, Glenn Fowler M, Mathieson BJ, Reichelderfer P, Nemo GJ, Korelitz J, Meyer WA, Sapan CV, Jimenez E, Gandia J, Scott G, O'Sullivan MJ, Kovacs A, Stek A, Shearer WT, Hammill H. Efficacy of zidovudine and human immunodeficiency virus (HIV) hyperimmune immunoglobulin for reducing perinatal HIV transmission from HIV-infected women with advanced disease: results of Pediatric AIDS Clinical Trials Group protocol 185. J Infect Dis. 1999 Mar; 179(3):567-75. PMID: 9952362.
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    153. Shearer WT. Monitoring cellular immune function in HIV infection by the delayed hypersensitivity skin test: alternative to the CD4 T-cell count? J Allergy Clin Immunol. 1999 Jan; 103(1 Pt 1):26-8. PMID: 9893180.
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    154. Pitt J, Schluchter M, Jenson H, Kovacs A, LaRussa P, McIntosh K, Boyer P, Cooper E, Goldfarb J, Hammill H, Hodes D, Peavy H, Sperling R, Tuomala R, Shearer W. Maternal and perinatal factors related to maternal-infant transmission of HIV-1 in the P2C2 HIV study: the role of EBV shedding. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV-1 Infection (P2C2 HIV) Study Group. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15; 19(5):462-70. PMID: 9859959.
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    155. Shearer WT. HIV infection and AIDS. Prim Care. 1998 Dec; 25(4):759-74. PMID: 9735117.
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    156. Sperling RS, Shapiro DE, McSherry GD, Britto P, Cunningham BE, Culnane M, Coombs RW, Scott G, Van Dyke RB, Shearer WT, Jimenez E, Diaz C, Harrison DD, Delfraissy JF. Safety of the maternal-infant zidovudine regimen utilized in the Pediatric AIDS Clinical Trial Group 076 Study. AIDS. 1998 Oct 1; 12(14):1805-13. PMID: 9792381.
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    157. Flaitz CM, Hicks MJ, Carter AB, Rossmann SN, Demmler GJ, Simon CL, Cron SG, Shearer WT, Kline MW. Saliva collection technique for cytologic, microbiologic and viral evaluation in pediatric HIV infection. ASDC J Dent Child. 1998 Sep-Oct; 65(5):318-24, 355. PMID: 9795735.
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    158. Rossmann SN, Wilson PH, Hicks J, Carter B, Cron SG, Simon C, Flaitz CM, Demmler GJ, Shearer WT, Kline MW. Isolation of Lautropia mirabilis from oral cavities of human immunodeficiency virus-infected children. J Clin Microbiol. 1998 Jun; 36(6):1756-60. PMID: 9620414; PMCID: PMC104914.
    159. Hicks MJ, Carter AB, Rossmann SN, Demmler GJ, Simon CL, Cron SG, Flaitz CM, Shearer WT, Kline MW. Detection of fungal organisms in saliva from HIV-infected children: a preliminary cytologic analysis. Pediatr Dent. 1998 May-Jun; 20(3):162-8. PMID: 9635310.
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    160. Noroski LM, Shearer WT. Screening for primary immunodeficiencies in the clinical immunology laboratory. Clin Immunol Immunopathol. 1998 Mar; 86(3):237-45. PMID: 9557156.
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    161. Pitt J, Goldfarb J, Schluchter M, Kovacs A, Cooper E, Hodes D, McIntosh K, Peavy H, Shearer W. HIV vertical transmission rate determinations are subject to differing definitions and therefore different rates. The Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group. J Clin Epidemiol. 1998 Feb; 51(2):159-64. PMID: 9474076.
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    162. Shearer WT, Kalish LA, Zimmerman PA. CCR5 HIV-1 vertical transmission. Women and Infants Transmission Study Group. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Feb 1; 17(2):180-1. PMID: 9473022.
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    163. Bacot BK, Paul ME, Navarro M, Abramson SL, Kline MW, Hanson IC, Rosenblatt HM, Shearer WT. Objective measures of allergic disease in children with human immunodeficiency virus infection. J Allergy Clin Immunol. 1997 Nov; 100(5):707-11. PMID: 9389303.
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    164. Sinclair JP, Shearer WT. Current Status of CD4-Based Therapies for Prophylaxis and Treatment of HIV Infection. BioDrugs. 1997 Aug; 8(2):128-38. PMID: 18020501.
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    165. Shearer WT, Reuben J, Lee BN, Popek EJ, Lewis DE, Hammill HH, Hanson IC, Kline MW, Langston C. Role of placental cytokines and inflammation in vertical transmission of HIV infection. Acta Paediatr Suppl. 1997 Jun; 421:33-8. PMID: 9240855.
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    166. Shearer WT, Langston C, Lewis DE, Pham EL, Hammill HH, Kozinetz CA, Kline MW, Hanson IC, Popek EJ. Early spontaneous abortions and fetal thymic abnormalities in maternal-to-fetal HIV infection. Acta Paediatr Suppl. 1997 Jun; 421:60-4. PMID: 9240860.
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    167. Tuomala RE, Kalish LA, Zorilla C, Fox H, Shearer W, Landay A, Vermund SH, Landesman S, Burns D. Changes in total, CD4+, and CD8+ lymphocytes during pregnancy and 1 year postpartum in human immunodeficiency virus-infected women. The Women and Infants Transmission Study. Obstet Gynecol. 1997 Jun; 89(6):967-74. PMID: 9170476.
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    168. Shearer WT, Quinn TC, LaRussa P, Lew JF, Mofenson L, Almy S, Rich K, Handelsman E, Diaz C, Pagano M, Smeriglio V, Kalish LA. Viral load and disease progression in infants infected with human immunodeficiency virus type 1. Women and Infants Transmission Study Group. N Engl J Med. 1997 May 8; 336(19):1337-42. PMID: 9134873.
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    169. Lee BN, Ordonez N, Popek EJ, Lu JG, Helfgott A, Eriksen N, Hammill H, Kozinetz C, Doyle M, Kline M, Langston C, Shearer WT, Reuben JM. Inflammatory cytokine expression is correlated with the level of human immunodeficiency virus (HIV) transcripts in HIV-infected placental trophoblastic cells. J Virol. 1997 May; 71(5):3628-35. PMID: 9094636; PMCID: PMC191511.
    170. Lee BN, Lu JG, Shen DY, Li S, Shearer WT, Reuben JM. Quantification of IL-2 and IL-2 receptor mRNA in peripheral blood mononuclear cells by the RT-PCR based SHARP Signal system. Cytokines Cell Mol Ther. 1997 Mar; 3(1):33-40. PMID: 9287242.
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    171. Armstrong D, Hawkins E, Rouah E, Shearer W, Gruber R. Graft-vs-host disease in the central nervous system. Am J Clin Pathol. 1997 Mar; 107(3):379. PMID: 9052393.
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    172. Reuben JM, Turpin JA, Lee BN, Doyle M, Gonik B, Jacobson R, Shearer WT. Induction of inflammatory cytokines in placental monocytes of gravidae infected with the human immunodeficiency virus type 1. J Interferon Cytokine Res. 1996 Nov; 16(11):963-71. PMID: 8938574.
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    173. Love JT, Shearer WT. Prevention, diagnosis, and treatment of pediatric HIV infection. Compr Ther. 1996 Nov; 22(11):719-26. PMID: 8978978.
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    174. Lee BN, Lu JG, Kline MW, Paul M, Doyle M, Kozinetz C, Shearer WT, Reuben JM. Type 1 and type 2 cytokine profiles in children exposed to or infected with vertically transmitted human immunodeficiency virus. Clin Diagn Lab Immunol. 1996 Sep; 3(5):493-9. PMID: 8877124; PMCID: PMC170395.
    175. Shearer WT. Anaphylaxis to disodium cromoglycate. Ann Allergy Asthma Immunol. 1996 Sep; 77(3):165. PMID: 8814038.
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    176. Kline MW, Fletcher CV, Federici ME, Harris AT, Evans KD, Rutkiewicz VL, Shearer WT, Dunkle LM. Combination therapy with stavudine and didanosine in children with advanced human immunodeficiency virus infection: pharmacokinetic properties, safety, and immunologic and virologic effects. Pediatrics. 1996 Jun; 97(6 Pt 1):886-90. PMID: 8657531.
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    177. O'Neal KD, Chari MV, Mcdonald CH, Cook RG, Yu-Lee LY, Morrisett JD, Shearer WT. Multiple cis-trans conformers of the prolactin receptor proline-rich motif (PRM) peptide detected by reverse-phase HPLC, CD and NMR spectroscopy. Biochem J. 1996 May 1; 315 ( Pt 3):833-44. PMID: 8645165; PMCID: PMC1217282.
    178. Shearer WT, Ruddy SG, Anderson JA. Conjoint versus separate boards. J Allergy Clin Immunol. 1996 Mar; 97(3):881-4. PMID: 8613652.
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    179. Shearer WT, Buckley RH, Engler RJ, Finn AF, Fleisher TA, Freeman TM, Herrod HG, Levinson AI, Lopez M, Rich RR, Rosenfeld SI, Rosenwasser LJ. Practice parameters for the diagnosis and management of immunodeficiency. The Clinical and Laboratory Immunology Committee of the American Academy of Allergy, Asthma, and Immunology (CLIC-AAAAI) Ann Allergy Asthma Immunol. 1996 Mar; 76(3):282-94. PMID: 8634885.
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    180. Kline MW, Paul ME, Bohannon B, Kozinetz CA, Shearer WT. Characteristics of children surviving to 5 years of age or older with vertically acquired HIV infection. Pediatr AIDS HIV Infect. 1995 Dec; 6(6):350-3. PMID: 11361459.
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    181. Langston C, Lewis DE, Hammill HA, Popek EJ, Kozinetz CA, Kline MW, Hanson IC, Shearer WT. Excess intrauterine fetal demise associated with maternal human immunodeficiency virus infection. J Infect Dis. 1995 Dec; 172(6):1451-60. PMID: 7594702.
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    182. O'Neal KD, Yu-Lee LY, Shearer WT. The proline-rich motif is necessary but not sufficient for prolactin receptor signal transduction. Ann N Y Acad Sci. 1995 Sep 7; 766:282-4. PMID: 7486672.
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    183. Love JT, Shearer WT. Hypogammaglobulinemia in HIV-infected infants. N Engl J Med. 1995 Aug 3; 333(5):321-2. PMID: 7596384.
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    184. O'Neal KD, Shearer WT. Clarification of the role of the Pro-X-Pro sequence in interleukin-5 receptor signal transduction. Mol Cell Biol. 1995 Aug; 15(8):4657-8. PMID: 7623858; PMCID: PMC230707.
    185. Shearer WT, Duliege AM, Kline MW, Hammill H, Minkoff H, Ammann AJ, Chen S, Izu A, Mordenti J. Transport of recombinant human CD4-immunoglobulin G across the human placenta: pharmacokinetics and safety in six mother-infant pairs in AIDS clinical trial group protocol 146. Clin Diagn Lab Immunol. 1995 May; 2(3):281-5. PMID: 7664172; PMCID: PMC170146.
    186. Kozinetz CA, Kline MW, Lewis DE, Hollinger BF, Reuben JM, Rosenblatt H, Hanson IC, Hammill H, Shearer WT. Early detection of HIV in infants: aspects of design and analysis for diagnostic test studies. Pediatr AIDS HIV Infect. 1995 Feb; 6(1):3-13. PMID: 11361742.
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    187. Lewis DE, Adu-Oppong A, Hollinger FB, Rosenblatt HM, Hanson IC, Reuben JM, Kline MW, Kozinetz CA, Shearer WT. Sensitivity of immune complex-dissociated p24 antigen testing for early detection of human immunodeficiency virus in infants. Clin Diagn Lab Immunol. 1995 Jan; 2(1):87-90. PMID: 7719918; PMCID: PMC170106.
    188. Kuruvilla A, Pielop C, Shearer WT. Platelet-activating factor induces the tyrosine phosphorylation and activation of phospholipase C-gamma 1, Fyn and Lyn kinases, and phosphatidylinositol 3-kinase in a human B cell line. J Immunol. 1994 Dec 15; 153(12):5433-42. PMID: 7989748.
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    189. Shearer WT, Adelman DC, Huston DP, Engler RJ, Gupta S, Ledford DK, Lopez M, Du Buske LM. Core content outline for clinical and laboratory immunology. AAAI Training Program Directors' Committee. J Allergy Clin Immunol. 1994 Dec; 94(6 Pt 1):933-41. PMID: 7798541.
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    190. Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O'Sullivan MJ, VanDyke R, Bey M, Shearer W, Jacobson RL, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med. 1994 Nov 3; 331(18):1173-80. PMID: 7935654.
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    191. Smith CS, Parker L, Shearer WT. Cytokine regulation by platelet-activating factor in a human B cell line. J Immunol. 1994 Nov 1; 153(9):3997-4005. PMID: 7930608.
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    192. Smith CS, Ortega G, Parker L, Shearer WT. Cyclosporin A blocks induction of tumor necrosis factor-alpha in human B lymphocytes. Biochem Biophys Res Commun. 1994 Oct 14; 204(1):383-90. PMID: 7524500.
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    193. Pacheco SE, Shearer WT. Laboratory aspects of immunology. Pediatr Clin North Am. 1994 Aug; 41(4):623-55. PMID: 8047365.
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    194. Patke CL, Green CG, Shearer WT. Differential effects of interleukin-2 and interleukin-4 on immunomodulatory role of platelet-activating factor in human B cells. Clin Diagn Lab Immunol. 1994 Jul; 1(4):424-32. PMID: 8556480; PMCID: PMC368281.
    195. Kline MW, Bocobo FC, Paul ME, Rosenblatt HM, Shearer WT. Successful medical therapy of Aspergillus osteomyelitis of the spine in an 11-year-old boy with chronic granulomatous disease. Pediatrics. 1994 May; 93(5):830-5. PMID: 8165091.
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    196. Smith CS, Shearer WT. Activation of NF-kappa B and immunoglobulin expression in response to platelet-activating factor in a human B cell line. Cell Immunol. 1994 May; 155(2):292-303. PMID: 8181066.
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    197. Foy TM, Hawkins EP, Peters KR, Shearer WT, Ferry GD. Colonic ulcers and lower GI bleeding due to disseminated aspergillosis. J Pediatr Gastroenterol Nutr. 1994 Apr; 18(3):399-403. PMID: 8057229.
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    198. Kline MW, Lewis DE, Hollinger FB, Reuben JM, Hanson LC, Kozinetz CA, Dimitrov DH, Rosenblatt HM, Shearer WT. A comparative study of human immunodeficiency virus culture, polymerase chain reaction and anti-human immunodeficiency virus immunoglobulin A antibody detection in the diagnosis during early infancy of vertically acquired human immunodeficiency virus infection. Pediatr Infect Dis J. 1994 Feb; 13(2):90-4. PMID: 8190557.
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    199. McClure JE, Noonan CA, Shearer WT. Okadaic acid inhibits dephosphorylation of cytoplasmic p53 during lymphocyte activation. Biochem Biophys Res Commun. 1993 Dec 30; 197(3):1578-84. PMID: 8280176.
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    200. Shearer WT, Rosenblatt HM, Schluchter MD, Mofenson LM, Denny TN. Immunologic targets of HIV infection: T cells. NICHD IVIG Clinical Trial Group, and the NHLBI P2C2 Pediatric Pulmonary and Cardiac Complications of HIV Infection Study Group. Ann N Y Acad Sci. 1993 Oct 29; 693:35-51. PMID: 7903519.
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    201. Kuruvilla A, Putcha G, Poulos E, Shearer WT. Tyrosine phosphorylation of phospholipase C concomitant with its activation by platelet-activating factor in a human B cell line. J Immunol. 1993 Jul 15; 151(2):637-48. PMID: 8393037.
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    202. Kline MW, Shearer WT. Evaluation of responses to pneumococcal vaccine. Ann Allergy. 1993 Apr; 70(4):261. PMID: 8466089.
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    203. Dimitrov DH, Hollinger FB, Baker CJ, Kline MW, Doyle M, Bremer JW, Shearer WT. Study of human immunodeficiency virus resistance to 2'-3'-dideoxyinosine and zidovudine in sequential isolates from pediatric patients on long-term therapy. J Infect Dis. 1993 Apr; 167(4):818-23. PMID: 8450246.
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    204. Shearer WT. [Intravenous administration of immunoglobulins for prevention of bacterial and viral infections in children with symptomatic HIV infection]. Infusionsther Transfusionsmed. 1993 Apr; 20 Suppl 1:78-9; discussion 80. PMID: 8098972.
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    205. Kline MW, Hollinger FB, Rosenblatt HM, Bohannon B, Kozinetz CA, Shearer WT. Sensitivity, specificity and predictive value of physical examination, culture and other laboratory studies in the diagnosis during early infancy of vertically acquired human immunodeficiency virus infection. Pediatr Infect Dis J. 1993 Jan; 12(1):33-6. PMID: 8417423.
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    206. McClure JE, McClure JA, Shearer WT. Phosphorylation-associated conformation shift of anti-oncogene phosphoprotein p53 in concanavalin-A activated human T lymphocytes. Biochem Biophys Res Commun. 1992 Dec 30; 189(3):1701-8. PMID: 1482375.
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    207. Kline MW, Bohannon B, Kozinetz CA, Rosenblatt HM, Shearer WT. Characteristics of human immunodeficiency virus-associated mortality in pediatric patients with vertically transmitted infection. Pediatr Infect Dis J. 1992 Aug; 11(8):676-7. PMID: 1523082.
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    208. Mofenson LM, Shearer WT, Moye J, Nugent R, Willoughby A. Manipulating the immune system with immune globulin. The National Institute of Child Health and Human Development. Intravenous Immunoglobulin Study Group. N Engl J Med. 1992 Jun 11; 326(24):1636-7; author reply 1637-8. PMID: 1584276.
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    209. Whelan JP, Shearer WT, Gilliam EB, Hardy KJ. A protein kinase C-activating phorbol ester accelerates the T cell antigen receptor-stimulated phosphatidylinositol cycle in normal human CD4+ T cells. J Immunol. 1992 May 1; 148(9):2872-8. PMID: 1349321.
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    210. Kline MW, Shearer WT. Impact of human immunodeficiency virus infection on women and infants. Infect Dis Clin North Am. 1992 Mar; 6(1):1-17. PMID: 1578110.
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    211. Kuruvilla A, Putcha G, Shearer WT. High-level expression of functional platelet-activating factor receptors on a human B lymphoblastoid cell line. Biochem Biophys Res Commun. 1991 Nov 14; 180(3):1318-24. PMID: 1659411.
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    212. Patke CL, Orson FM, Shearer WT. Cyclic AMP-mediated modulation of immunoglobulin production in B cells by prostaglandin E1. Cell Immunol. 1991 Oct 1; 137(1):36-45. PMID: 1715816.
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    213. Gilliam EB, Schulam PG, Whelan JP, Rosenblatt HM, Shearer WT. Phorbol ester plus calcium ionophore induces release of arachidonic acid from membrane phospholipids of a human B cell line. Cell Immunol. 1991 Aug; 136(1):41-53. PMID: 1905589.
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    214. Blomquist MD, Boggards M, Hanson IC, Rosenblatt HM, Pollack MS, Hawkins E, Ritz J, Shearer WT. Monoclonal anti-T cell (T12) antibody treatment of graft-versus-host disease in severe combined immunodeficiency: targeting of antibody and activation of complement on CD8+ cytotoxic T cell surfaces. J Allergy Clin Immunol. 1991 May; 87(5):1029-33. PMID: 1902852.
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    215. Kline MW, Shearer WT. A national survey on the care of infants and children with human immunodeficiency virus infection. J Pediatr. 1991 May; 118(5):817-21. PMID: 2019940.
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    216. Schulam PG, Kuruvilla A, Putcha G, Mangus L, Franklin-Johnson J, Shearer WT. Platelet-activating factor induces phospholipid turnover, calcium flux, arachidonic acid liberation, eicosanoid generation, and oncogene expression in a human B cell line. J Immunol. 1991 Mar 1; 146(5):1642-8. PMID: 1847170.
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    217. Foster S, Hawkins E, Hanson CG, Shearer W. Pathology of the kidney in childhood immunodeficiency: AIDS-related nephropathy is not unique. Pediatr Pathol. 1991 Jan-Feb; 11(1):63-74. PMID: 2014193.
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    218. Harrison LF, Shearer WT. Evaluation and management of B and T cell abnormalities. Allergy Proc. 1991 Jan-Feb; 12(1):25-30. PMID: 2040445.
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    219. Shearer WT. Treatment of symptomatic children infected with human immunodeficiency virus. J Infect Dis. 1990 Nov; 162(5):1209-10. PMID: 2230248.
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    220. Patke CL, Shearer WT. Enhancement of cyclic AMP metabolism in a B cell line by protein kinase C. Cell Immunol. 1990 Oct 1; 130(1):22-31. PMID: 2168809.
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    221. Schulam PG, Shearer WT. Evidence for 5-lipoxygenase activity in human B cell lines. A possible role for arachidonic acid metabolites during B cell signal transduction. J Immunol. 1990 Apr 1; 144(7):2696-701. PMID: 2108210.
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    222. Schulam PG, Putcha G, Franklin-Johnson J, Shearer WT. Evidence for a platelet-activating factor receptor on human lymphoblastoid B cells: activation of the phosphatidylinositol cycle and induction of calcium mobilization. Biochem Biophys Res Commun. 1990 Jan 30; 166(2):1047-52. PMID: 2154211.
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    223. Shearer WT. Specific diagnostic modalities: IgE, skin tests, and RAST. J Allergy Clin Immunol. 1989 Dec; 84(6 Pt 2):1112-6. PMID: 2600349.
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    224. Borzy MS, Ridgway D, Noya FJ, Shearer WT. Successful bone marrow transplantation with split lymphoid chimerism in DiGeorge syndrome. J Clin Immunol. 1989 Sep; 9(5):386-92. PMID: 2621243.
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    225. Buffone GJ, Shearer WT, Finegold MJ. New methodologies. Their role in pediatric pathology. Pediatr Clin North Am. 1989 Feb; 36(1):227-56. PMID: 2643797.
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    226. Gorin LJ, Jeha SC, Sullivan MP, Rosenblatt HM, Shearer WT. Burkitt's lymphoma developing in a 7-year-old boy with hyper-IgE syndrome. J Allergy Clin Immunol. 1989 Jan; 83(1):5-10. PMID: 2783597.
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    227. McClure JE, Shearer WT. Radioimmunoassay for anti-actin antibody: application in viral and autoimmune diseases. Mol Cell Probes. 1988 Dec; 2(4):305-19. PMID: 3073313.
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    228. Shearer WT, Patke CL, Gilliam EB, Rosenblatt HM, Barron KS, Orson FM. Modulation of a human lymphoblastoid B cell line by cyclic AMP. Ig secretion and phosphatidylcholine metabolism. J Immunol. 1988 Sep 1; 141(5):1678-86. PMID: 2457623.
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    229. Cleary ML, Nalesnik MA, Shearer WT, Sklar J. Clonal analysis of transplant-associated lymphoproliferations based on the structure of the genomic termini of the Epstein-Barr virus. Blood. 1988 Jul; 72(1):349-52. PMID: 2839256.
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    230. Rouah E, Gruber R, Shearer W, Armstrong D, Hawkins EP. Graft-versus-host disease in the central nervous system. A real entity? Am J Clin Pathol. 1988 Apr; 89(4):543-6. PMID: 3281437.
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    231. Shearer WT, Gilliam EB, Rosenblatt HM, Barron KS, Orson FM. Phorbol ester binding to a human lymphoblastoid B-cell line, LA350, stimulates 32P incorporation into selected phospholipids and immunoglobulin secretion. Cell Immunol. 1988 Feb; 111(2):316-31. PMID: 3257418.
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    232. Shearer WT, Gilliam EB, Rosenblatt HM, Orson FM. Anti-mu antibody stimulates the phosphatidylinositol cycle and immunoglobulin secretion in a human lymphoblastoid B-cell line, LA350. Cell Immunol. 1988 Feb; 111(2):296-315. PMID: 2827896.
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    233. Rosenblatt HM, Lewis DE, Sklar J, Cleary ML, Parikh N, Galili N, Ritz J, Shearer WT. Epstein-Barr virus-transformed B-cell line (DV-1) derived from bone marrow of a patient with severe combined immunodeficiency and immunoblastic lymphoma. Pediatr Res. 1987 Apr; 21(4):331-7. PMID: 3033590.
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    234. Rosenblatt HM, Green CG, McClure JE, Shearer WT. Antibody to human lymphocyte actin regulates immunoglobulin secretion by an EBV-transformed human B-cell line. Biochem Biophys Res Commun. 1986 Oct 15; 140(1):399-405. PMID: 3022720.
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    235. Guerra IC, Shearer WT. Environmental control in management of immunodeficient patients: experience with "David". Clin Immunol Immunopathol. 1986 Jul; 40(1):128-35. PMID: 3521965.
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    236. Guerra IC, Fawcett WA, Redmon AH, Lawrence EC, Rosenblatt HM, Shearer WT. Permanent intrinsic B cell immunodeficiency caused by phenytoin hypersensitivity. J Allergy Clin Immunol. 1986 Apr; 77(4):603-7. PMID: 3082959.
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    237. Bach MA, Lewis DE, McClure JE, Parikh N, Rosenblatt HM, Shearer WT. Monoclonal anti-actin antibody recognizes a surface molecule on normal and transformed human B lymphocytes: expression varies with phase of cell cycle. Cell Immunol. 1986 Apr 1; 98(2):364-74. PMID: 3489550.
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    238. Fawcett WA, Ferry GD, Gorin LJ, Rosenblatt HM, Brown BS, Shearer WT. Immunodeficiency secondary to structural intestinal defects. Malrotation of the small bowel and cavernous hemangioma of the jejunum. Am J Dis Child. 1986 Feb; 140(2):169-72. PMID: 3484895.
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    239. Das C, Shearer WT, Langone JJ. Characterization of complexes containing protein A and rabbit immunoglobulin G or Fc gamma fragments. Res Commun Chem Pathol Pharmacol. 1986 Jan; 51(1):117-28. PMID: 3952366.
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    240. Shearer WT, Green CG, McClure JE. Anti-rabbit thymus actin antibody inhibits proliferation of Epstein-Barr virus-transformed human B cell line LA350: augmentation by cyclic AMP. Biochem Biophys Res Commun. 1985 Oct 30; 132(2):837-43. PMID: 2998386.
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    241. McClure JE, Moore WP, Green CG, Shearer WT. Identification of L-cell growth stimulating antibody as anti-actin. Cell Immunol. 1985 Oct 15; 95(2):218-33. PMID: 3899374.
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    242. Rosenblatt HM, Parikh N, McClure JE, Meza I, Hwo SY, Bryan J, Shearer WT. Mitogen-like monoclonal anti-actin antibodies. J Immunol. 1985 Aug; 135(2):995-1000. PMID: 4008931.
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    243. Rosenblatt HM, Ulrich RG, Shearer WT. Monoclonal anti-actin antibody modulates expression of surface antigen on L cells. Res Commun Chem Pathol Pharmacol. 1985 Jul; 49(1):35-45. PMID: 3929344.
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    244. Shearer WT, Ulrich RG, McClure JE, Green CG, Gilliam EB, Das C, Langone JJ. Cyclic AMP and theophylline enhance DNA synthesis in L cells stimulated with anti-actin IgG and [(IgG)2 protein A]2 complex by recruiting cells into S-phase. Mol Cell Biochem. 1985 Jul; 67(2):135-44. PMID: 2995789.
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    245. Anderson DC, Schmalstieg FC, Shearer W, Becker-Freeman K, Kohl S, Smith CW, Tosi MF, Springer T. Leukocyte LFA-1, OKM1, p150,95 deficiency syndrome: functional and biosynthetic studies of three kindreds. Fed Proc. 1985 Jul; 44(10):2671-7. PMID: 3891420.
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    246. Shearer WT, Ritz J, Finegold MJ, Guerra IC, Rosenblatt HM, Lewis DE, Pollack MS, Taber LH, Sumaya CV, Grumet FC, et al. Epstein-Barr virus-associated B-cell proliferations of diverse clonal origins after bone marrow transplantation in a 12-year-old patient with severe combined immunodeficiency. N Engl J Med. 1985 May 2; 312(18):1151-9. PMID: 2984567.
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    247. Langone JJ, Das C, Mainwaring R, Shearer WT. Complexes prepared from protein A and human serum, IgG, or Fc gamma fragments: characterization by immunochemical analysis of ultracentrifugation fractions and studies on their interconversion. Mol Cell Biochem. 1985 Jan; 65(2):159-70. PMID: 3157047.
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    248. Shearer WT, Gilliam EB, McClure JE. Protein phosphorylation in anti-actin IgG and [(IgG)2protein A]2 complex-stimulated L cells. Cell Immunol. 1984 Nov; 89(1):55-65. PMID: 6488332.
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    249. Barron KS, Lewis DE, Brewer EJ, Marcus DM, Shearer WT. Cytotoxic anti-T cell antibodies in children with juvenile rheumatoid arthritis. Arthritis Rheum. 1984 Nov; 27(11):1272-80. PMID: 6437413.
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    250. Shearer WT, Gilliam EB. PGE1 not PGF2 alpha reverses the anti-actin antibody stimulation of protein phosphorylation and DNA synthesis in L cells. Biochem Biophys Res Commun. 1984 Oct 15; 124(1):23-8. PMID: 6594137.
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    251. Shearer WT, Green CG, Gilliam EB, Langone JJ. [(IgG)2 protein A]2 complex stimulates cytosine arabinoside incorporation into DNA and inhibits L cell proliferation. Immunopharmacology. 1984 Oct; 8(2):103-10. PMID: 6511365.
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    252. Paschall VL, Brown LA, Lawrence EC, Karol RA, Lotzova E, Brown BS, Shearer WT. Immunoregulation in an isolated 12-year-old boy with congenital severe combined immunodeficiency. Pediatr Res. 1984 Aug; 18(8):723-8. PMID: 6332299.
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    253. Shearer WT, Moore EG. Correlation between covalent attachment of C3 and calcium uptake in antibody-stimulated L cells. Res Commun Chem Pathol Pharmacol. 1984 Aug; 45(2):163-78. PMID: 6484308.
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    254. Ulrich RG, Shearer WT. Enhanced N-acylation of palmitic acid in sphingomyelin of antibody-stimulated L cells. Biochem Biophys Res Commun. 1984 Jun 15; 121(2):605-11. PMID: 6732827.
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    255. Shearer WT, Moore EG, Ulrich RG, Green CG, McClure JE. Antibody to immunoselected L-cell antigens mimics stimulating activity of antibody to whole L cells. Cell Immunol. 1984 Jun; 86(1):230-41. PMID: 6722893.
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    256. Shearer WT, Green CG, Patel P, Langone JJ. IgG-protein A complexes modulate thymidine incorporation into DNA of antibody and complement-stimulated cells. J Immunol. 1984 May; 132(5):2279-84. PMID: 6715880.
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    257. Shearer WT, Ulrich RG. Incorporation of fatty acids into phospholipids in L cells stimulated by antibody. Lipids. 1984 Apr; 19(4):239-49. PMID: 6425590.
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    258. Balint J, Ikeda Y, Langone JJ, Shearer WT, Daskal I, Meek K, Cook G, Henry J, Terman DS. Tumoricidal response following perfusion over immobilized protein A: identification of immunoglobulin oligomers in serum after perfusion and their partial characterization. Cancer Res. 1984 Feb; 44(2):734-43. PMID: 6607106.
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    259. Stiehm ER, DeVivo DC, Brann AW, Fisher DA, Hodson WA, New MI, Shearer WT, Sokol RJ, Sunshine P, Taeusch HW. Advances in perinatology from the clinical research centers. Pediatr Res. 1984 Feb; 18(2):197-212. PMID: 6366722.
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    260. Shearer WT, Green CG, Mettes HJ. Modulation of metabolism of cytosine arabinoside in L cells by antibody and complement. Immunopharmacology. 1983 Oct; 6(3):203-14. PMID: 6629738.
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    261. Karol RA, Eng J, Cooper JB, Dennison DK, Sawyer MK, Lawrence EC, Marcus DM, Shearer WT. Imbalances in subsets of T lymphocytes in an inbred pedigree with Omenn's syndrome. Clin Immunol Immunopathol. 1983 Jun; 27(3):412-27. PMID: 6223759.
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    262. Cooper JB, Pratt WR, English BK, Shearer WT. Coxsackievirus B3 producing fatal meningoencephalitis in a patient with X-linked agammaglobulinemia. Am J Dis Child. 1983 Jan; 137(1):82-3. PMID: 6293302.
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    263. Brown LA, Goldberg ND, Shearer WT. Long-term ticarcillin desensitization by the continuous oral administration of penicillin. J Allergy Clin Immunol. 1982 Jan; 69(1 Pt 1):51-4. PMID: 6798088.
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    264. Brown LA, Kaplan RA, Benjamin PA, Hoffman LS, Shearer WT. Immunoglobulin E-mediated anaphylaxis with inhaled cromolyn sodium. J Allergy Clin Immunol. 1981 Dec; 68(6):416-20. PMID: 6796617.
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    265. Terman DS, Young JB, Shearer WT, Ayus C, Lehane D, Mattioli C, Espada R, Howell JF, Yamamoto T, Zaleski HI, Miller L, Frommer P, Feldman L, Henry JF, Tillquist R, Cook G, Daskal Y. Preliminary observations of the effects on breast adenocarcinoma of plasma perfused over immobilized protein A. N Engl J Med. 1981 Nov 12; 305(20):1195-200. PMID: 6270553.
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    266. Shearer WT, Richards JE. Rapid turnover of arachidonyl-phosphatidylinositol in L cells stimulated by antibody. Biochem Biophys Res Commun. 1981 Aug 14; 101(3):800-6. PMID: 7306115.
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    267. Shearer WT, Moore EG. Humoral immunostimulation. X. Cytochalasin B stimulates complement-dependent calcium uptake in antibody-treated cells. Cell Immunol. 1981 Jun; 61(1):62-77. PMID: 7261066.
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    268. Terman DS, Yamamoto T, Tillquist RL, Henry JF, Cook GL, Silvers A, Shearer WT. Tumoricidal response induced by cytosine arabinoside after plasma perfusion over protein A. Science. 1980 Sep 12; 209(4462):1257-9. PMID: 7403885.
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    269. Tanner DD, Buckley PJ, Hong R, Shearer WT. Fatal cytomegalovirus bronchiolitis in a patient with Nezelof's syndrome. Pediatrics. 1980 Jan; 65(1):98-102. PMID: 6243769.
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    270. Shearer WT, Mettes HJ. Humoral immunostimulation. IX. Selective growth inhibition of L cells in vitro with cytosine arabinoside and antibody. J Immunol. 1979 Dec; 123(6):2763-71. PMID: 501088.
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    271. Hartman BK, Agrawal HC, Kalmbach S, Shearer WT. A comparative study of the immunohistochemical localization of basic protein to myelin and oligodendrocytes in rat and chicken brain. J Comp Neurol. 1979 Nov 15; 188(2):273-90. PMID: 91628.
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    272. Shearer WT, Parker CW. Antibody and complement modulation of tumor cell growth in vitro and in vivo. Fed Proc. 1978 Aug; 37(10):2385-9. PMID: 354972.
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    273. Berger NA, Adams JW, Sikorski GW, Petzold SJ, Shearer WT. Synthesis of DNA and poly(adenosine diphosphate ribose) in normal and chronic lymphocytic leukemia lymphocytes. J Clin Invest. 1978 Jul; 62(1):111-8. PMID: 659624; PMCID: PMC371743.
    274. Shearer WT, Wedner HJ, Strominger DB, Kissane J, Hong R. Successful transplantation of the thymus in Nezelof's syndrome. Pediatrics. 1978 Apr; 61(4):619-24. PMID: 307221.
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    275. Shearer WT, Crouch JA. Humoral immunostimulation. VIII. Increased incorporation of phosphate and turnover of phosphatidylinositol in cells treated with antibody. J Immunol. 1977 Sep; 119(3):911-7. PMID: 894029.
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    276. Shearer WT, Gottlieb C, Kornfeld S. Humoral immunostimulation. VII. Sialic acid masks antigenic sites on an antibody-selected bariant cell line. J Immunol. 1977 Aug; 119(2):614-7. PMID: 69664.
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    277. Beale MG, Shearer WT, Karl MM, Robson AM. Long-term effects of dioxin exposure. Lancet. 1977 Apr 2; 1(8014):748. PMID: 66537.
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    278. Agrawal HC, Hartman BK, Shearer WT, Kalmbach S, Margolis FL. Purification and immunohistochemical localization of rat brain myelin proteolipid protein. J Neurochem. 1977 Mar; 28(3):495-508. PMID: 404395.
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    279. Shearer WT, Atkinson JP, Parker CW. Humoral immunostimulation. VI. Increased calcium uptake by cells treated with antibody and complement. J Immunol. 1976 Sep; 117(3):973-80. PMID: 956662.
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    280. Shearer WT, Kobayashi G, Prensky AL. Presumptive histoplasmosis presenting as cerebellar ataxia with spontaneous recovery. Pediatrics. 1976 Jan; 57(1):150-2. PMID: 1246491.
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    281. Feigin RD, Shearer WT. Opportunistic infection in children. III. In the normal host. J Pediatr. 1975 Dec; 87(6 Pt 1):852-66. PMID: 171360.
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    282. Shearer WT, Parker CW. Humoral immunostimulation. V. Selection of variant cell lines. J Exp Med. 1975 Nov 1; 142(5):1133-49. PMID: 1194850; PMCID: PMC2189957.
    283. Feigin RD, Shearer WT. Opportunistic infection in children. II. In the compromised host. J Pediatr. 1975 Nov; 87(5):677-94. PMID: 1102640.
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    284. Feigin RD, Shearer WT. Opportunistic infection in children. I. In the compromised host. J Pediatr. 1975 Oct; 87(4):507-14. PMID: 1099182.
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    285. Shearer WT, Parker CW. Humoral immunostimulation. III. Requirements for divalent antibody and cellular aggregation. J Immunol. 1975 Sep; 115(3):613-9. PMID: 807644.
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    286. Shearer WT, Philpott GW, Parker CW. Alteration of L cell growth by antibody-stimulated incorporation of radioactive nucleosides. Res Commun Chem Pathol Pharmacol. 1975 Jun; 11(2):303-9. PMID: 1171516.
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    287. Shearer WT, Philpott GW, Parker CW. Humoral immunostimulation. II. Increased nucleoside incorporation, DNA synthesis, and cell growth in L cells treated with anti-L cell antibody. Cell Immunol. 1975 Jun; 17(2):447-62. PMID: 1125994.
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    288. Fink MP, Parker CW, Shearer WT. Antibody stimulation of tumour growth in T-cell depleted mice. Nature. 1975 May 29; 255(5507):404-5. PMID: 1079329.
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    289. Shearer WT, Atkinson JP, Frank MM, Parker CW. Humoral immunostimulation. IV. Role of complement. J Exp Med. 1975 Apr 1; 141(4):736-52. PMID: 1168690; PMCID: PMC2189750.
    290. Shearer WT, Turnbaugh TR, Coleman WE, Aach RD, Philpott GW, Parker CW. Cytotoxicity with antibody-glucose oxidase conjugates specific for a human colonic cancer and carcinoembryonic antigen. Int J Cancer. 1974 Oct 15; 14(4):539-47. PMID: 4477557.
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    291. Philpott GW, Bower RJ, Parker KL, Shearer WT, Parker CW. Affinity cytotoxicity of tumor cells with antibody-glucose oxidase conjugates, peroxidase, and arsphenamine. Cancer Res. 1974 Sep; 34(9):2159-64. PMID: 4858425.
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    292. Shearer WT, Philpott GW, Parker CW. Humoral immunostimulation. I. Increased uptake of (125I)iododeoxyuridine and (3H)thymidine into TNP-cells treated with anti-TNP antibody. J Exp Med. 1974 Feb 1; 139(2):367-79. PMID: 4855754; PMCID: PMC2139524.
    293. Shearer WT, Keating JP, Hutsell TC. Lomotil toxicity in children. Case report. Mo Med. 1974 Feb; 71(2):74-8. PMID: 4812196.
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    294. Shearer WT, Philpott GW, Parker CW. Stimulation of cells by antibody. Science. 1973 Dec 28; 182(4119):1357-9. PMID: 4128221.
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    295. Philpott GW, Shearer WT, Bower RJ, Parker CW. Selective cytotoxicity of hapten-substituted cells with an antibody-enzyme conjugate. J Immunol. 1973 Sep; 111(3):921-9. PMID: 4582264.
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    296. Feigin RD, Zarkowsky HF, Shearer W, Anderson DC. Thrombocytopenia following administration of para-aminosalicylic acid. J Pediatr. 1973 Sep; 83(3):502-3. PMID: 4541998.
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    297. Shearer WT, Schreiner RL, Ward SP, Marshall RE, Strominger DB, McAlister WH, Kissane J, Ogura JH. Benign nasal tumor appearing as neonatal respiratory distress. First reported case of nasopharyngeal fibrous histiocytoma. Am J Dis Child. 1973 Aug; 126(2):238-41. PMID: 4353311.
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    298. Shackelford PG, Ratzan SA, Shearer WT. Ecthyma gangrenosum produced by Aeromonas hydrophilia. J Pediatr. 1973 Jul; 83(1):100-1. PMID: 4358653.
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    299. Schreiner RL, McAlister WH, Marshall RE, Shearer WT. Stickler syndrome in a pedigree of Pierre Robin syndrome. Am J Dis Child. 1973 Jul; 126(1):86-90. PMID: 4198747.
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    300. Bloom ME, Shearer WT, Barton LL. Oculoglandular tularemia in an inner city child. Pediatrics. 1973 Mar; 51(3):564-6. PMID: 4575107.
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    301. Shearer WT, Schreiner RL, Marshall RE, Barton LL. Cytomegalovirus infection in a newborn dizygous twin. J Pediatr. 1972 Dec; 81(6):1161-5. PMID: 4345239.
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    302. Shearer WT, Schreiner RL, Marshall RE. Urinary retention in a neonate secondary to maternal ingestion of nortriptyline. J Pediatr. 1972 Sep; 81(3):570-2. PMID: 5049831.
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    303. Shearer WT, Biller HF, Ogura JH, Goldring D. Congenital laryngeal web and interventricular septal defect. First reported cases. Am J Dis Child. 1972 Jun; 123(6):605-7. PMID: 5033249.
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    304. Shearer WT, Graff RJ, Eisen HN. Preliminary observations on immunity in BALB-c mice to myeloma tumor of BALB-c origin. Transplantation. 1972 Mar; 13(3):345-7. PMID: 5021442.
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    305. Shearer WT, Rutman JY, Weinberg WA, Goldring D. Coarctation of the aorta and cerebrovascular accident: a proposal for early corrective surgery. J Pediatr. 1970 Dec; 77(6):1004-9. PMID: 5486617.
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    306. Bradshaw RA, Shearer WT, Gurd FR. Sites of binding of copper (II) ion by peptide (1-24) of bovine serum albumin. J Biol Chem. 1968 Jul 25; 243(14):3817-25. PMID: 5690816.
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    307. Shearer WT, Bradshaw RA, Gurd FR, Peters T. The amino acid sequence and copper(II)-binding properties of peptide (1-24) of bovine serum albumin. J Biol Chem. 1967 Dec 10; 242(23):5451-9. PMID: 12325359.
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    308. Shearer WT, Brown RK. Optical rotatory dispersion of peptides which inhibit the oxidized ribonuclease immune system. Immunochemistry. 1967 May; 4(3):127-34. PMID: 5584603.
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    309. Shearer WT, Brown RK, Bryce GF, Gurd FR. Reversible disruption by cupric ions of a helical conformation of a polypeptide derived from ribonuclease. J Biol Chem. 1966 Jun 10; 241(11):2665-71. PMID: 5911639.
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