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STEPHANIE A PANGAS

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
DivisionPathology
AddressDepartment of Pathology
One Baylor Plaza
Houston TX 77030
Email
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    Collapse Biography 
    Collapse awards and honors
    2013New Investigator Award -Society for the Study of Reproduction, Society for the Study of Reproduction
    2007 - 2009Duncan Scholar -Dan L. Duncan Cancer Center, Bayor College of Medicine

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    Research Summary
    Twenty percent of women’s health problems worldwide are attributed to reproductive and sexual health issues. Disruptions in normal reproductive function cause health problems that extend beyond infertility, and include increases in cardiovascular disease, osteoporosis, and cognitive disorders. Furthermore, ovarian cancer is the most lethal gynecologic malignancy in women. In part, this is due to a lack of diagnostics needed for early detection. Therefore, the origin, diagnosis, and treatment of gynecological diseases are critical health issues that need to be addressed. Our research laboratory focuses on understanding how the ovary normally develops and functions, and how defects in these processes result in reproductive disorders and cancer development. We use a multifaceted approach, generating data from patient samples, immortalized cancer cell lines, and genetically modified mice. Since the laboratory has started in 2007, our research has contributed a number of key mouse models for genes that cause infertility, ovarian dysfunction, and ovarian cancer. These models are paramount in the search for novel therapeutics and diagnostics for patients with reproductive diseases.

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    Ovarian Cancer
    Infertility
    Reproductive Biology
    Ovary


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Rajkovic A, Pangas S. Ovary as a Biomarker of Health and Longevity: Insights from Genetics. Semin Reprod Med. 2017 May; 35(3):231-240. PMID: 28658706.
      View in: PubMed
    2. Monsivais D, Matzuk MM, Pangas SA. The TGF-? Family in the Reproductive Tract. Cold Spring Harb Perspect Biol. 2017 Feb 13. PMID: 28193725.
      View in: PubMed
    3. Wu H, Pangas SA, Eldin KW, Patel KR, Hicks J, Dietrich JE, Venkatramani R. Juvenile granulosa cell tumor of the ovary: a clinicopathologic study. J Pediatr Adolesc Gynecol. 2016 Oct 1. PMID: 27702598.
      View in: PubMed
    4. Rodriguez A, Tripurani SK, Burton JC, Clementi C, Larina I, Pangas SA. SMAD Signaling Is Required for Structural Integrity of the Female Reproductive Tract and Uterine Function During Early Pregnancy in Mice. Biol Reprod. 2016 Aug; 95(2):44. PMID: 27335065.
      View in: PubMed
    5. Rodriguez A, Pangas SA. Regulation of germ cell function by SUMOylation. Cell Tissue Res. 2016 Jan; 363(1):47-55. PMID: 26374733.
      View in: PubMed
    6. Peng J, Monsivais D, You R, Zhong H, Pangas SA, Matzuk MM. Uterine activin receptor-like kinase 5 is crucial for blastocyst implantation and placental development. Proc Natl Acad Sci U S A. 2015 Sep 8; 112(36):E5098-107. PMID: 26305969.
      View in: PubMed
    7. Liu Z, Ren YA, Pangas SA, Adams J, Zhou W, Castrillon DH, Wilhelm D, Richards JS. FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development. Mol Endocrinol. 2015 Jul; 29(7):1006-24. PMID: 26061565.
      View in: PubMed
    8. Mansouri-Attia N, Tripurani SK, Gokul N, Piard H, Anderson ML, Eldin K, Pangas SA. TGF? signaling promotes juvenile granulosa cell tumorigenesis by suppressing apoptosis. Mol Endocrinol. 2014 Nov; 28(11):1887-98. PMID: 25243859; PMCID: PMC4213364.
    9. Mansouri-Attia N, James R, Ligon A, Li X, Pangas SA. Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line. Biol Reprod. 2014 Oct; 91(4):100. PMID: 25165122; PMCID: PMC4435027.
    10. Clementi C, Tripurani SK, Large MJ, Edson MA, Creighton CJ, Hawkins SM, Kovanci E, Kaartinen V, Lydon JP, Pangas SA, DeMayo FJ, Matzuk MM. Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. PLoS Genet. 2013 Nov; 9(11):e1003863. PMID: 24244176; PMCID: PMC3828128.
    11. Myers M, Mansouri-Attia N, James R, Peng J, Pangas SA. GDF9 modulates the reproductive and tumor phenotype of female inha-null mice. Biol Reprod. 2013 Apr; 88(4):86. PMID: 23446452; PMCID: PMC4013870.
    12. Pangas SA. Regulation of the ovarian reserve by members of the transforming growth factor beta family. Mol Reprod Dev. 2012 Oct; 79(10):666-79. PMID: 22847922; PMCID: PMC3473177.
    13. Tripurani SK, Cook RW, Eldin KW, Pangas SA. BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors. Oncogene. 2013 Aug 15; 32(33):3877-85. PMID: 22964636; PMCID: PMC3525720.
    14. Li X, Tripurani SK, James R, Pangas SA. Minimal fertility defects in mice deficient in oocyte-expressed Smad4. Biol Reprod. 2012 Jan; 86(1):1-6. PMID: 21900682.
      View in: PubMed
    15. Szigeti R, Pangas SA, Nagy-Szakal D, Dowd SE, Shulman RJ, Olive AP, Popek EJ, Finegold MJ, Kellermayer R. SMAD4 haploinsufficiency associates with augmented colonic inflammation in select humans and mice. Ann Clin Lab Sci. 2012; 42(4):401-8. PMID: 23090737; PMCID: PMC3875295.
    16. Myers M, Tripurani SK, Middlebrook B, Economides AN, Canalis E, Pangas SA. Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice. Biol Reprod. 2011 Dec; 85(6):1175-82. PMID: 21832168; PMCID: PMC3223251.
    17. Pangas SA. Bone morphogenetic protein signaling transcription factor (SMAD) function in granulosa cells. Mol Cell Endocrinol. 2012 Jun 5; 356(1-2):40-7. PMID: 21763749; PMCID: PMC3203253.
    18. Nagaraja AK, Middlebrook BS, Rajanahally S, Myers M, Li Q, Matzuk MM, Pangas SA. Defective gonadotropin-dependent ovarian folliculogenesis and granulosa cell gene expression in inhibin-deficient mice. Endocrinology. 2010 Oct; 151(10):4994-5006. PMID: 20739397; PMCID: PMC2946151.
    19. Edson MA, Nalam RL, Clementi C, Franco HL, Demayo FJ, Lyons KM, Pangas SA, Matzuk MM. Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development. Mol Endocrinol. 2010 Jun; 24(6):1251-66. PMID: 20363875; PMCID: PMC2875809.
    20. Richards JS, Pangas SA. The ovary: basic biology and clinical implications. J Clin Invest. 2010 Apr; 120(4):963-72. PMID: 20364094; PMCID: PMC2846061.
    21. Myers M, Pangas SA. Regulatory roles of transforming growth factor beta family members in folliculogenesis. Wiley Interdiscip Rev Syst Biol Med. 2010 Jan-Feb; 2(1):117-25. PMID: 20836015.
      View in: PubMed
    22. Richards JS, Pangas SA. New insights into ovarian function. Handb Exp Pharmacol. 2010; (198):3-27. PMID: 20839083; PMCID: PMC4551424.
    23. Middlebrook BS, Eldin K, Li X, Shivasankaran S, Pangas SA. Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors. Endocrinology. 2009 Dec; 150(12):5208-17. PMID: 19819941; PMCID: PMC2819741.
    24. Myers M, Middlebrook BS, Matzuk MM, Pangas SA. Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis. Dev Biol. 2009 Oct 15; 334(2):458-67. PMID: 19666016; PMCID: PMC2753717.
    25. Li Q, Pangas SA, Jorgez CJ, Graff JM, Weinstein M, Matzuk MM. Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo. Mol Cell Biol. 2008 Dec; 28(23):7001-11. PMID: 18809571; PMCID: PMC2593383.
    26. Su YQ, Sugiura K, Wigglesworth K, O'Brien MJ, Affourtit JP, Pangas SA, Matzuk MM, Eppig JJ. Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells. Development. 2008 Jan; 135(1):111-21. PMID: 18045843.
      View in: PubMed
    27. Pangas SA, Li X, Umans L, Zwijsen A, Huylebroeck D, Gutierrez C, Wang D, Martin JF, Jamin SP, Behringer RR, Robertson EJ, Matzuk MM. Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Mol Cell Biol. 2008 Jan; 28(1):248-57. PMID: 17967875; PMCID: PMC2223289.
    28. Pangas SA, Jorgez CJ, Tran M, Agno J, Li X, Brown CW, Kumar TR, Matzuk MM. Intraovarian activins are required for female fertility. Mol Endocrinol. 2007 Oct; 21(10):2458-71. PMID: 17609433.
      View in: PubMed
    29. Pangas SA. Growth factors in ovarian development. Semin Reprod Med. 2007 Jul; 25(4):225-34. PMID: 17594603.
      View in: PubMed
    30. Sugiura K, Su YQ, Diaz FJ, Pangas SA, Sharma S, Wigglesworth K, O'Brien MJ, Matzuk MM, Shimasaki S, Eppig JJ. Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells. Development. 2007 Jul; 134(14):2593-603. PMID: 17553902.
      View in: PubMed
    31. Suzumori N, Pangas SA, Rajkovic A. Candidate genes for premature ovarian failure. Curr Med Chem. 2007; 14(3):353-7. PMID: 17305537.
      View in: PubMed
    32. Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, Rajkovic A. Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8090-5. PMID: 16690745; PMCID: PMC1472434.
    33. Ballow DJ, Xin Y, Choi Y, Pangas SA, Rajkovic A. Sohlh2 is a germ cell-specific bHLH transcription factor. Gene Expr Patterns. 2006 Oct; 6(8):1014-8. PMID: 16765102.
      View in: PubMed
    34. Pangas SA, Li X, Robertson EJ, Matzuk MM. Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice. Mol Endocrinol. 2006 Jun; 20(6):1406-22. PMID: 16513794.
      View in: PubMed
    35. Pangas SA, Rajkovic A. Transcriptional regulation of early oogenesis: in search of masters. Hum Reprod Update. 2006 Jan-Feb; 12(1):65-76. PMID: 16143663.
      View in: PubMed
    36. Yan W, Ma L, Stein P, Pangas SA, Burns KH, Bai Y, Schultz RM, Matzuk MM. Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility. Mol Cell Biol. 2005 Jun; 25(11):4615-24. PMID: 15899864; PMCID: PMC1140637.
    37. Pangas SA, Matzuk MM. The art and artifact of GDF9 activity: cumulus expansion and the cumulus expansion-enabling factor. Biol Reprod. 2005 Oct; 73(4):582-5. PMID: 15917343.
      View in: PubMed
    38. Pangas SA, Yan W, Matzuk MM, Rajkovic A. Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein. Gene Expr Patterns. 2004 Dec; 5(2):257-63. PMID: 15567723.
      View in: PubMed
    39. Pangas SA, Matzuk MM. Genetic models for transforming growth factor beta superfamily signaling in ovarian follicle development. Mol Cell Endocrinol. 2004 Oct 15; 225(1-2):83-91. PMID: 15451572.
      View in: PubMed
    40. McKenzie LJ, Pangas SA, Carson SA, Kovanci E, Cisneros P, Buster JE, Amato P, Matzuk MM. Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF. Hum Reprod. 2004 Dec; 19(12):2869-74. PMID: 15471935.
      View in: PubMed
    41. Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM. NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science. 2004 Aug 20; 305(5687):1157-9. PMID: 15326356.
      View in: PubMed
    42. Pangas SA, Jorgez CJ, Matzuk MM. Growth differentiation factor 9 regulates expression of the bone morphogenetic protein antagonist gremlin. J Biol Chem. 2004 Jul 30; 279(31):32281-6. PMID: 15133038.
      View in: PubMed
    43. Pangas SA, Saudye H, Shea LD, Woodruff TK. Novel approach for the three-dimensional culture of granulosa cell-oocyte complexes. Tissue Eng. 2003 Oct; 9(5):1013-21. PMID: 14633385.
      View in: PubMed
    44. Pangas SA, Rademaker AW, Fishman DA, Woodruff TK. Localization of the activin signal transduction components in normal human ovarian follicles: implications for autocrine and paracrine signaling in the ovary. J Clin Endocrinol Metab. 2002 Jun; 87(6):2644-57. PMID: 12050229.
      View in: PubMed
    45. Pangas SA, Woodruff TK. Production and purification of recombinant human inhibin and activin. J Endocrinol. 2002 Jan; 172(1):199-210. PMID: 11786387.
      View in: PubMed
    46. Pangas SA, Woodruff TK. Activin signal transduction pathways. Trends Endocrinol Metab. 2000 Oct; 11(8):309-14. PMID: 10996525.
      View in: PubMed
    47. Chong H, Pangas SA, Bernard DJ, Wang E, Gitch J, Chen W, Draper LB, Cox ET, Woodruff TK. Structure and expression of a membrane component of the inhibin receptor system. Endocrinology. 2000 Jul; 141(7):2600-7. PMID: 10875264.
      View in: PubMed
    48. Jurivich DA, Pangas S, Qiu L, Welk JF. Phospholipase A2 triggers the first phase of the thermal stress response and exhibits cell-type specificity. J Immunol. 1996 Aug 15; 157(4):1669-77. PMID: 8759754.
      View in: PubMed
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