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HIRAM F GILBERT

TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
DivisionBiochemistry & Molecular Biology
AddressOne Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Stojanoski V, Chow DC, Hu L, Sankaran B, Gilbert HF, Prasad BV, Palzkill T. A triple mutant in the ?-loop of TEM-1 ?-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis. J Biol Chem. 2015 Apr 17; 290(16):10382-94. PMID: 25713062; PMCID: PMC4400348.
    2. Adamski CJ, Cardenas AM, Brown NG, Horton LB, Sankaran B, Prasad BV, Gilbert HF, Palzkill T. Molecular basis for the catalytic specificity of the CTX-M extended-spectrum ?-lactamases. Biochemistry. 2015 Jan 20; 54(2):447-57. PMID: 25489790; PMCID: PMC4303298.
    3. Yuan J, Cardenas AM, Gilbert HF, Palzkill T. Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase. Protein Sci. 2011 Nov; 20(11):1891-906. PMID: 21898650; PMCID: PMC3267953.
    4. Arredondo SA, Chen TF, Riggs AF, Gilbert HF, Georgiou G. Role of dimerization in the catalytic properties of the Escherichia coli disulfide isomerase DsbC. J Biol Chem. 2009 Sep 4; 284(36):23972-9. PMID: 19581640; PMCID: PMC2781991.
    5. Kim JH, Zhao Y, Pan X, He X, Gilbert HF. The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization. J Biol Chem. 2009 Apr 17; 284(16):10400-8. PMID: 19233841; PMCID: PMC2667727.
    6. Arredondo S, Segatori L, Gilbert HF, Georgiou G. De novo design and evolution of artificial disulfide isomerase enzymes analogous to the bacterial DsbC. J Biol Chem. 2008 Nov 14; 283(46):31469-76. PMID: 18782764; PMCID: PMC2581571.
    7. Segatori L, Murphy L, Arredondo S, Kadokura H, Gilbert H, Beckwith J, Georgiou G. Conserved role of the linker alpha-helix of the bacterial disulfide isomerase DsbC in the avoidance of misoxidation by DsbB. J Biol Chem. 2006 Feb 24; 281(8):4911-9. PMID: 16280324.
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    8. Samudio I, Konopleva M, Hail N, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M. 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. J Biol Chem. 2005 Oct 28; 280(43):36273-82. PMID: 16118208.
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    9. Xiao R, Lundström-Ljung J, Holmgren A, Gilbert HF. Catalysis of thiol/disulfide exchange. Glutaredoxin 1 and protein-disulfide isomerase use different mechanisms to enhance oxidase and reductase activities. J Biol Chem. 2005 Jun 3; 280(22):21099-106. PMID: 15814611.
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    10. Wilkinson B, Xiao R, Gilbert HF. A structural disulfide of yeast protein-disulfide isomerase destabilizes the active site disulfide of the N-terminal thioredoxin domain. J Biol Chem. 2005 Mar 25; 280(12):11483-7. PMID: 15649885.
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    11. Xiao R, Wilkinson B, Solovyov A, Winther JR, Holmgren A, Lundström-Ljung J, Gilbert HF. The contributions of protein disulfide isomerase and its homologues to oxidative protein folding in the yeast endoplasmic reticulum. J Biol Chem. 2004 Nov 26; 279(48):49780-6. PMID: 15377672.
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    12. Segatori L, Paukstelis PJ, Gilbert HF, Georgiou G. Engineered DsbC chimeras catalyze both protein oxidation and disulfide-bond isomerization in Escherichia coli: Reconciling two competing pathways. Proc Natl Acad Sci U S A. 2004 Jul 6; 101(27):10018-23. PMID: 15220477; PMCID: PMC454158.
    13. Solovyov A, Xiao R, Gilbert HF. Sulfhydryl oxidation, not disulfide isomerization, is the principal function of protein disulfide isomerase in yeast Saccharomyces cerevisiae. J Biol Chem. 2004 Aug 13; 279(33):34095-100. PMID: 15175335.
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    14. Wilkinson B, Gilbert HF. Protein disulfide isomerase. Biochim Biophys Acta. 2004 Jun 1; 1699(1-2):35-44. PMID: 15158710.
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    15. Solovyov A, Gilbert HF. Zinc-dependent dimerization of the folding catalyst, protein disulfide isomerase. Protein Sci. 2004 Jul; 13(7):1902-7. PMID: 15169950; PMCID: PMC2279941.
    16. Schwaller M, Wilkinson B, Gilbert HF. Reduction-reoxidation cycles contribute to catalysis of disulfide isomerization by protein-disulfide isomerase. J Biol Chem. 2003 Feb 28; 278(9):7154-9. PMID: 12486139.
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    17. Liu CW, Millen L, Roman TB, Xiong H, Gilbert HF, Noiva R, DeMartino GN, Thomas PJ. Conformational remodeling of proteasomal substrates by PA700, the 19 S regulatory complex of the 26 S proteasome. J Biol Chem. 2002 Jul 26; 277(30):26815-20. PMID: 12011044.
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    18. Zheng J, Gilbert HF. Discrimination between native and non-native disulfides by protein-disulfide isomerase. J Biol Chem. 2001 May 11; 276(19):15747-52. PMID: 11278905.
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    19. Primm TP, Gilbert HF. Hormone binding by protein disulfide isomerase, a high capacity hormone reservoir of the endoplasmic reticulum. J Biol Chem. 2001 Jan 5; 276(1):281-6. PMID: 11035025.
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    20. Sideraki V, Huang W, Palzkill T, Gilbert HF. A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation. Proc Natl Acad Sci U S A. 2001 Jan 2; 98(1):283-8. PMID: 11114163; PMCID: PMC14582.
    21. Sideraki V, Gilbert HF. Mechanism of the antichaperone activity of protein disulfide isomerase: facilitated assembly of large, insoluble aggregates of denatured lysozyme and PDI. Biochemistry. 2000 Feb 8; 39(5):1180-8. PMID: 10653666.
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    22. Gilbert HF. Protein disulfide isomerase. Methods Enzymol. 1998; 290:26-50. PMID: 9534149.
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    23. Puig A, Primm TP, Surendran R, Lee JC, Ballard KD, Orkiszewski RS, Makarov V, Gilbert HF. A 21-kDa C-terminal fragment of protein-disulfide isomerase has isomerase, chaperone, and anti-chaperone activities. J Biol Chem. 1997 Dec 26; 272(52):32988-94. PMID: 9407079.
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    24. Gilbert HF. Protein disulfide isomerase and assisted protein folding. J Biol Chem. 1997 Nov 21; 272(47):29399-402. PMID: 9367991.
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    25. Walker KW, Gilbert HF. Scanning and escape during protein-disulfide isomerase-assisted protein folding. J Biol Chem. 1997 Apr 4; 272(14):8845-8. PMID: 9082998.
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    26. Primm TP, Walker KW, Gilbert HF. Facilitated protein aggregation. Effects of calcium on the chaperone and anti-chaperone activity of protein disulfide-isomerase. J Biol Chem. 1996 Dec 27; 271(52):33664-9. PMID: 8969236.
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    27. Chang Z, Primm TP, Jakana J, Lee IH, Serysheva I, Chiu W, Gilbert HF, Quiocho FA. Mycobacterium tuberculosis 16-kDa antigen (Hsp16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation. J Biol Chem. 1996 Mar 22; 271(12):7218-23. PMID: 8636160.
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    28. Walker KW, Lyles MM, Gilbert HF. Catalysis of oxidative protein folding by mutants of protein disulfide isomerase with a single active-site cysteine. Biochemistry. 1996 Feb 13; 35(6):1972-80. PMID: 8639681.
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    29. Walker KW, Gilbert HF. Oxidation of kinetically trapped thiols by protein disulfide isomerase. Biochemistry. 1995 Oct 17; 34(41):13642-50. PMID: 7577954.
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    30. Gilbert HF. Thiol/disulfide exchange equilibria and disulfide bond stability. Methods Enzymol. 1995; 251:8-28. PMID: 7651233.
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    31. Lyles MM, Gilbert HF. Mutations in the thioredoxin sites of protein disulfide isomerase reveal functional nonequivalence of the N- and C-terminal domains. J Biol Chem. 1994 Dec 9; 269(49):30946-52. PMID: 7983029.
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    32. Walker KW, Gilbert HF. Effect of redox environment on the in vitro and in vivo folding of RTEM-1 beta-lactamase and Escherichia coli alkaline phosphatase. J Biol Chem. 1994 Nov 11; 269(45):28487-93. PMID: 7961790.
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    33. Puig A, Gilbert HF. Anti-chaperone behavior of BiP during the protein disulfide isomerase-catalyzed refolding of reduced denatured lysozyme. J Biol Chem. 1994 Oct 14; 269(41):25889-96. PMID: 7929293.
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    34. Gilbert HF. Protein chaperones and protein folding. Curr Opin Biotechnol. 1994 Oct; 5(5):534-9. PMID: 7765469.
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    35. Puig A, Lyles MM, Noiva R, Gilbert HF. The role of the thiol/disulfide centers and peptide binding site in the chaperone and anti-chaperone activities of protein disulfide isomerase. J Biol Chem. 1994 Jul 22; 269(29):19128-35. PMID: 7913469.
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    36. Morjana NA, Gilbert HF. Catalysis of protein folding by agarose-immobilized protein disulfide isomerase. Protein Expr Purif. 1994 Apr; 5(2):144-8. PMID: 8054846.
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    37. Puig A, Gilbert HF. Protein disulfide isomerase exhibits chaperone and anti-chaperone activity in the oxidative refolding of lysozyme. J Biol Chem. 1994 Mar 11; 269(10):7764-71. PMID: 7907332.
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    38. Morjana NA, McKeone BJ, Gilbert HF. Guanidine hydrochloride stabilization of a partially unfolded intermediate during the reversible denaturation of protein disulfide isomerase. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2107-11. PMID: 8460117; PMCID: PMC46034.
    39. Cappel RE, Gilbert HF. Oxidative inactivation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and subunit cross-linking involve different dithiol/disulfide centers. J Biol Chem. 1993 Jan 5; 268(1):342-8. PMID: 8416941.
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    40. Lu X, Gilbert HF, Harper JW. Conserved residues flanking the thiol/disulfide centers of protein disulfide isomerase are not essential for catalysis of thiol/disulfide exchange. Biochemistry. 1992 May 5; 31(17):4205-10. PMID: 1567868.
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    41. Chung PM, Cappel RE, Gilbert HF. Inhibition of glutathione disulfide reductase by glutathione. Arch Biochem Biophys. 1991 Jul; 288(1):48-53. PMID: 1898023.
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    42. Morjana NA, Gilbert HF. Effect of protein and peptide inhibitors on the activity of protein disulfide isomerase. Biochemistry. 1991 May 21; 30(20):4985-90. PMID: 2036365.
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    43. Gilbert HF, Kruzel ML, Lyles MM, Harper JW. Expression and purification of recombinant rat protein disulfide isomerase from Escherichia coli. Protein Expr Purif. 1991 Apr-Jun; 2(2-3):194-8. PMID: 1821789.
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    44. Lyles MM, Gilbert HF. Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: pre-steady-state kinetics and the utilization of the oxidizing equivalents of the isomerase. Biochemistry. 1991 Jan 22; 30(3):619-25. PMID: 1988051.
      View in: PubMed
    45. Lyles MM, Gilbert HF. Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: dependence of the rate on the composition of the redox buffer. Biochemistry. 1991 Jan 22; 30(3):613-9. PMID: 1988050.
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    46. Cappel RE, Gilbert HF. The effects of NADPH and 3-hydroxy-3-methylglutaryl-CoA on the thiol/disulfide redox behavior of rat liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase. J Biol Chem. 1990 Sep 15; 265(26):15464-70. PMID: 2394734.
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    47. Gilbert HF. Molecular and cellular aspects of thiol-disulfide exchange. Adv Enzymol Relat Areas Mol Biol. 1990; 63:69-172. PMID: 2407068.
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    48. Gilbert HF. Catalysis of thiol/disulfide exchange: single-turnover reduction of protein disulfide-isomerase by glutathione and catalysis of peptide disulfide reduction. Biochemistry. 1989 Sep 5; 28(18):7298-305. PMID: 2819070.
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    49. Izbicka E, Gilbert HF. Examination of the role of thiolimidate formation in the cleavage of acetoacetyl-CoA catalyzed by thiolase I from porcine heart. Arch Biochem Biophys. 1989 Aug 1; 272(2):476-80. PMID: 2568819.
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    50. Cappel RE, Gilbert HF. The effects of mevinolin on the thiol/disulfide exchange between 3-hydroxy-3-methyglutaryl-coenzyme A reductase and glutathione. J Biol Chem. 1989 Jun 5; 264(16):9180-7. PMID: 2722823.
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    51. Cappel RE, Gilbert HF. Thiol/disulfide exchange between 3-hydroxy-3-methylglutaryl-CoA reductase and glutathione. A thermodynamically facile dithiol oxidation. J Biol Chem. 1988 Sep 5; 263(25):12204-12. PMID: 3410841.
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    52. Clancey CJ, Gilbert HF. Thiol/disulfide exchange in the thioredoxin-catalyzed reductive activation of spinach chloroplast fructose-1,6-bisphosphatase. Kinetics and thermodynamics. J Biol Chem. 1987 Oct 5; 262(28):13545-9. PMID: 2820974.
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    53. Gilbert HF, O'Leary MH. Modification of arginine and lysine in proteins with 2,4-pentanedione. Biochemistry. 1975 Nov 18; 14(23):5194-9. PMID: 43.
      View in: PubMed
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